CN115068575B

CN115068575B - Traditional Chinese medicine composition for treating recurrent oral ulcer

Info

Publication number: CN115068575B
Application number: CN202210876908.3A
Authority: CN
Inventors: 俞夏莉
Original assignee: First Affiliated Hospital of ZCMU
Current assignee: First Affiliated Hospital of ZCMU
Priority date: 2022-07-25
Filing date: 2022-07-25
Publication date: 2024-01-30
Anticipated expiration: 2042-07-25
Also published as: CN115068575A

Abstract

The invention provides a traditional Chinese medicine composition for treating recurrent oral ulcer, which comprises the following components in parts by mass: 15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig. Other Chinese medicinal components can also be contained. The traditional Chinese medicine formula provided by the invention can be used for preparing medicines for treating recurrent oral ulcer, has good clinical curative effect on recurrent oral ulcer patients through long-term clinical application practice, and can relieve pain of ulcer, accelerate healing speed of ulcer and reduce recurrence frequency of ulcer. The traditional Chinese medicine composition has better improving effect on repeated recrudescence and canker sore with long disease course, and is a good prescription for treating canker sore which is not healed after the disease.

Description

Traditional Chinese medicine composition for treating recurrent oral ulcer

Technical Field

The invention relates to a traditional Chinese medicine composition for treating recurrent oral ulcer.

Background

Recurrent oral ulcer (Recurrent oral ulceration, ROU) is a clinical common oral mucosa disease with unknown etiology, has self-limiting, periodic and recurrent pathogenesis and is related to abnormal immune function, is influenced by multiple factors such as heredity, diet, emotion, infection, endocrine and the like, can not be radically cured at present, and can improve symptoms to a certain extent, but an ideal treatment means is not yet available.

Aiming at oral mucosa symptoms, modern clinic uses anti-inflammatory preparations such as chlorhexidine, povidone iodine and the like to rinse, and analgesic preparations such as ulcer patches, iodized glycerol, lidocaine gel and the like to carry out symptomatic treatment by local external application, but the effect is poor, and serious patients need to use glucocorticoids and immunosuppressants in a whole body, so that the oral mucosa symptoms have more adverse reactions of medicines and are easy to relapse after stopping the medicines. The traditional Chinese medicine has the effects of dialectical treatment, decoction or patent medicine for oral administration, tin powder, watermelon frost, external ulcer powder and the like. The external medicine can not solve the essential problem of yin-yang imbalance and deficiency-excess inclusion of patients with recurrent oral ulcer, and has poor curative effect on severe recurrent oral ulcer. At present, the oral administration patent medicine for treating the dental ulcer is mainly used for clearing heat and removing toxicity, but clinical practice observation shows that the constitution of a patient with recurrent dental ulcer is mainly used for treating yang deficiency, and the treatment principle of clearing heat and removing toxicity is not consistent with the constitution of the patient with recurrent dental ulcer, and the curative effect is poor.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating recurrent oral ulcer, which has remarkable curative effect.

The technical scheme adopted by the invention is as follows:

a traditional Chinese medicine composition for treating recurrent oral ulcer comprises the following components in parts by mass:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig.

Further, the traditional Chinese medicine composition is preferably composed of the following components in parts by mass:

Further, the Chinese medicinal composition may also contain other Chinese medicinal components, and the Chinese medicinal composition may contain one or more of semen Ziziphi Spinosae, os Draconis preparata, concha Ostreae preparata, radix Saposhnikoviae, cimicifugae rhizoma, radix Puerariae preparata, fructus Psoraleae, alismatis rhizoma, cortex moutan, corni fructus, herba Artemisiae Annuae, and herba Hedyotidis Diffusae.

Still further, the formula of the traditional Chinese medicine composition is preferably one or a combination of a basic formula and a formula A, B, C, wherein the basic formula comprises 15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white in people and 5-10 parts of cassia twig;

the formula A consists of the following components in parts by mass: 15-30 parts of wild jujube seed, 10-15 parts of calcined dragon bone and 10-15 parts of calcined oyster;

the formula B consists of the following components in parts by mass: 5-10 parts of divaricate saposhnikovia root, 6-10 parts of cimicifuga foetida, 20-30 parts of roasted kudzuvine root, 5-10 parts of fructus psoraleae, 10-15 parts of rhizoma alismatis, 6-10 parts of cortex moutan and 6-12 parts of cornus officinalis;

the formula C consists of the following components in parts by mass: 15-30 parts of sweet wormwood herb, 10-30 parts of hedyotis diffusa

The traditional Chinese medicine composition is preferably one of the following formulas:

combination of formulation (one) base formulation and formulation a:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig; 15-30 parts of wild jujube seed, 10-15 parts of calcined dragon bone and 10-15 parts of calcined oyster;

combination of formulation (two) base formulation and formulation B:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig; 5-10 parts of divaricate saposhnikovia root, 6-10 parts of cimicifuga foetida, 20-30 parts of roasted kudzuvine root, 5-10 parts of fructus psoraleae, 10-15 parts of rhizoma alismatis, 6-10 parts of cortex moutan and 6-12 parts of cornus officinalis;

combination of formulation (iii) base formulation and formulation C:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig; 15-30 parts of sweet wormwood herb, 10-30 parts of hedyotis diffusa;

combination of formulation (four) base formulation and formulation A, B:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig; 15-30 parts of wild jujube seed, 10-15 parts of calcined dragon bone and 10-15 parts of calcined oyster; 5-10 parts of divaricate saposhnikovia root, 6-10 parts of cimicifuga foetida, 20-30 parts of roasted kudzuvine root, 5-10 parts of fructus psoraleae, 10-15 parts of rhizoma alismatis, 6-10 parts of cortex moutan and 6-12 parts of cornus officinalis;

combination of formulation (five) base formulation and formulation B, C:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig; 5-10 parts of divaricate saposhnikovia root, 6-10 parts of cimicifuga foetida, 20-30 parts of roasted kudzuvine root, 5-10 parts of fructus psoraleae, 10-15 parts of rhizoma alismatis, 6-10 parts of cortex moutan and 6-12 parts of cornus officinalis; 15-30 parts of sweet wormwood herb, 10-30 parts of hedyotis diffusa;

combination of formulation (six) base formulation and formulation A, C:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white paeony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 10-15 parts of radix cyathulae, 10-15 parts of white ginseng and 5-10 parts of cassia twig; 15-30 parts of wild jujube seed, 10-15 parts of calcined dragon bone and 10-15 parts of calcined oyster; 15-30 parts of sweet wormwood herb, 10-30 parts of hedyotis diffusa;

combination of formulation (seven) base formulation and formulation A, B, C:

15-30 parts of radix pseudostellariae, 10-12 parts of stir-fried bighead atractylodes rhizome, 6-10 parts of stir-fried white peony root, 10-15 parts of Chinese yam, 10-15 parts of poria cocos, 10-12 parts of radix curcumae, 10-12 parts of cortex albiziae, 10-15 parts of radix scutellariae, 6-9 parts of pinellia ternate, 3-5 parts of coptis chinensis, 20-30 parts of roasted kudzuvine root, 5-10 parts of cassia twig, 5-10 parts of fructus psoraleae, 10-15 parts of rhizoma alismatis, 6-10 parts of cortex moutan, 6-12 parts of cornus officinalis, 10-15 parts of radix cyathulae, 15-30 parts of spina date seed, 10-15 parts of calcined dragon bone, 10-15 parts of calcined oyster, 15-30 parts of sweet wormwood herb, 10-30 parts of hedyotis diffusa, 10-15 parts of white in human body, 5-10 parts of radix sileris and 6-10 parts of rhizoma cimicifugae.

Still further, the traditional Chinese medicine composition is preferably a formula (seven), wherein the formula (seven) is preferably composed of the following components in parts by mass:

30 parts of radix pseudostellariae, 12 parts of stir-fried bighead atractylodes rhizome, 10 parts of stir-fried white peony root, 15 parts of Chinese yam, 10 parts of poria cocos, 10 parts of radix curcumae, 10 parts of cortex albiziae, 15 parts of radix scutellariae, 9 parts of pinellia ternate, 3 parts of coptis chinensis, 30 parts of roasted kudzuvine root, 10 parts of cassia twig, 10 parts of fructus psoraleae, 10 parts-15 parts of rhizoma alismatis, 6 parts-10 parts of cortex moutan, 6 parts-12 parts of cornus officinalis, 10 parts of radix cyathulae, 15 parts of semen zizyphi spinosae, 15 parts of calcined dragon bone, 15 parts of calcined oyster, 30 parts of sweet wormwood herb, 15 parts of hedyotis diffusa, 10 parts of white in people, 10 parts of radix sileris and 10 parts of cimicifugae foetidae.

The invention also provides application of the traditional Chinese medicine composition in preparing medicines for treating recurrent oral ulcer.

Furthermore, the basic formula can be used for preparing medicines for treating recurrent oral ulcer with symptoms of vexation, irritability, aversion to cold, cold limbs and loose stool.

The formula (I) can be used for preparing medicines for treating recurrent oral ulcer with symptoms of poor sleep, difficulty in falling asleep, dysphoria and dreaminess.

The formula (II) can be used for preparing medicines for treating recurrent oral ulcer with serious symptoms of soreness and weakness of waist and knees, aversion to cold, fatigue, sinking of middle-jiao and loose stool.

The formula (III) can be used for preparing medicines for treating recurrent oral ulcer with symptoms of hectic fever, night sweat and fear of fever and enjoying cool.

The formula (IV) can be used for preparing medicines for treating recurrent oral ulcer with serious symptoms of poor sleep, difficulty in falling asleep, dysphoria and dreaminess, soreness and weakness of waist and knees, aversion to cold, fatigue, depression of middle-jiao and loose stool.

The formula (five) can be used for preparing medicines for treating recurrent oral ulceration with symptoms of yin and yang deficiency, such as long-term yang deficiency constitution, aversion to cold, fatigue, loose stool, hectic fever and night sweat, aversion to heat and cool in summer and obvious aversion to cold in winter.

The formula (six) can be used for preparing the medicine for treating recurrent oral ulcer with symptoms of poor sleep, difficulty in falling asleep, dysphoria and dreaminess, hectic fever and night sweat, and fear of heat and cool preference.

The formula (seven) can be used for preparing medicines for treating recurrent oral ulcer with symptoms of long-term yang deficiency constitution, aversion to cold, fatigue, loose stool, tidal fever and night sweat in recent times, aversion to heat and cool in summer and obvious yin and yang deficiency of cold in winter, and simultaneously, patients have symptoms of unsmooth emotion, poor sleep, difficulty in falling asleep and dysphoria and dreaminess.

The traditional Chinese medicine composition provided by the invention is generally decocted in water to prepare decoction for use.

The traditional Chinese medicine formula provided by the invention takes the principles of upper heat clearing, cold and heat regulating, yang warming, spleen strengthening, liver soothing, depression relieving, nerve soothing and sleep aiding as treatment, and is subjected to dialectical compatibility of the formula, and after the medicine is used by a patient, yin and yang can be harmonized, and ulcer healing is promoted, so that the purpose of treatment is achieved. The prescription has good clinical curative effect on patients with recurrent oral ulcer through long-term clinical application practice, and can relieve the pain of the ulcer, accelerate the healing speed of the ulcer and reduce the recurrence frequency of the ulcer. The traditional Chinese medicine composition has better improving effect on repeated recrudescence and canker sore with long disease course, and is a good prescription for treating canker sore which is not healed after the disease.

Detailed Description

The technical scheme of the present invention is further described in the following specific examples, but the scope of the present invention is not limited thereto.

Example 1

The traditional Chinese medicine composition is used for treating patients with recurrent oral ulcer, and is suitable for screening patients:

inclusion criteria: recurrent oral ulcer patients: meets the relevant diagnosis standard in oral mucosa disease science (the disease time is less than 10d, and the oral mucosa and keratinization binding parts have single or a plurality of ulcers with different shapes, and the disease repeatedly attacks for more than 3 times). Unlimited, age > 18 years, agrees to participate and signs "informed consent" person.

Exclusion criteria: (1) and those with severe mental abnormalities cannot be matched.

The specific using method comprises the following steps: 40 patients with recurrent oral ulcer were treated in the hospitals in Zhejiang province at 1 month 2020 to 12 months, and the ulcer improvement condition was tracked and counted, and the statistical average is shown in Table 1. After one week of common treatment, the duration of single dental ulcer of a patient is shortened, the time between recurrent cases is prolonged, the pain degree of the ulcer is reduced, the number is reduced, the range is also reduced, the improvement rate of clinical symptoms before and after the patient uses the method can reach more than 50%, and the effect is very remarkable.

TABLE 1

Of the 40 patients, 26 patients used the base formulation. The remaining patients adjust the prescription on the basis of the basic recipe according to the specific condition.

The basic formula is as follows:

30g of radix pseudostellariae, 12g of stir-fried bighead atractylodes rhizome, 10g of stir-fried white peony root, 15g of Chinese yam, 10g of poria cocos, 10g of radix curcumae, 10g of cortex albiziae, 15g of radix scutellariae, 9g of pinellia ternate, 3g of coptis chinensis, 10g of radix cyathulae, 10g of white in people and 10g of cassia twig. The medicine is taken twice a day with 200mL each time by decocting with water.

Several typical cases are listed below:

case 1

Chen Mou it is suitable for women, 62 years old, and has the advantages of repeated oral ulcer, no vulva ulcer, no fever, no arthralgia, and improved treatment effect such as reaction stopping and vitamins. The long-term oral administration of the medicine can stop the maintenance treatment and the illness state is stable. The oral ulcer is aggravated before 1 month, with the symptoms of tingling of the lips, pain and discomfort after standing for a long time, soreness and weakness, cold feeling, loose stool. The tongue body is normal, the tongue is pale and white, the tongue tip is red, the tongue fur is thin and white, and the pulse is thin and weak. Considering "recurrent oral ulcer", stopping reaction, treating recurrent oral ulcer with traditional Chinese medicine formula (formula II) for 2 weeks, gradually healing the original oral ulcer, and making a small amount of new oral ulcer shallower, healed faster, improving sleep and relieving normal stool. After the recurrent oral ulcer is treated by taking the traditional Chinese medicine composition for 4 weeks, the oral ulcer heals, no new oral ulcer exists, the numbness of lips is gradually relieved, the waist soreness is improved, and the cold feeling is improved.

The composition is as follows: 15g of radix pseudostellariae, 12g of fried bighead atractylodes rhizome, 6g of fried white peony root, 15g of Chinese yam, 10g of turmeric root-tuber, 10g of cortex albiziae, 15g of baikal skullcap root, 6g of pinellia tuber, 3g of medicinal cyathula root, 10g of cassia twig, 10g of divaricate saposhnikovia root, 10g of cimicifuga rhizome, 6g of roasted kudzuvine root, 10g of malaytea scurfpea fruit, 10g of oriental waterplantain rhizome, 10g of tree peony bark and 10g of cornus.

Case 2

Zhan Mou it is a recurrent oral ulcer, which can self-heal and is untreated, and is a female 42 years old, and has no dental ulcer, no vulva ulcer, no joint swelling and pain, and no ophthalmia before 10 years old. Vulvar ulcer, joint discomfort, acne, ophthalmia, even abdominal pain, vexation, irritability, poor sleep, hectic fever, night sweat, slightly thin stool, normal tongue body, red and tender tongue, thin and white tongue fur, and weak pulse appear 5-6 years ago. The traditional Chinese medicine formula (formula six) for treating recurrent oral ulcer is used for 2 weeks, the oral ulcer of a patient heals, the symptoms of hectic fever and night sweat are relieved, the sleep is improved, the emotion is improved, and the stool is shaped.

The composition is as follows:

15g of radix pseudostellariae, 12g of fried bighead atractylodes rhizome, 6g of fried white peony root, 15g of Chinese yam, 10g of turmeric root-tuber, 10g of silktree albizia bark, 15g of pinellia tuber, 3g of Chinese medicinal herb, 10g of medicinal cyathula root, 10g of cassia twig, 10g of wild jujube seed, 15g of calcined dragon bone, 15g of calcined oyster shell, 15g of sweet wormwood herb and 10g of common hedyotis herb.

Example 2

The prescription of the application is obtained by the inventor through long-time fumbling experiments in long-term clinical practice, and the lack of any one of the basic formulas can lead to the reduction of curative effect, and specific cases are given below.

The patient can self-heal after repeated canker sore for several years and the patient does not visit the doctor after 7-14 days of attack. In month 4 2020, the patient has recurrent oral ulcer, obvious pain, no rash, no alopecia and no external ulcer. After the patient is tired for nearly one week, the canker sore is aggravated, a plurality of deep and large ulcers in the oral cavity are obvious in pain, and the patient is not healed for a plurality of days. Pale and tender tongue, margin and teeth marks, red tip, thin and white coating and weak pulse.

Seven pastes of Chinese medicine are prepared as follows:

radix astragali 10g radix pseudostellariae 15g Poria cocos 15g fried white peony root 10g fried white atractylodes rhizome 10g ginger processed pinellia tuber 10g radix scutellariae 10g radix scrophulariae 10g cassia twig 9g prepared rehmannia root 10g Chinese yam 15g cornus officinalis 10g medicinal cyathula root 10g fructus psoraleae 10g semen zizaniae caduciflorae 15g white in people 10g

Pain was relieved after 2 days of administration, and canker sore was substantially relieved after 1 week.

The patient is required to take the traditional Chinese medicine consolidation treatment again, the traditional Chinese medicine treatment is carried out again to other doctors, 10g of safflower is added on the basis of the original prescription, seven patches are carried out again, and the patient with poor curative effect refuses to take the medicine again.

Radix astragali 10g radix pseudostellariae 15g Poria cocos 15g fried white peony root 10g fried white atractylodes rhizome 10g ginger processed pinellia tuber 10g baikal skullcap root 10g safflower 10g cassia twig 9g prepared rehmannia root 10g Chinese yam 15g cornus officinalis 10g medicinal cyathula root 10g psoralea fruit 10g spina date seed 15g white atractylodes rhizome 10g

The patient in 2022 month 5 recurs again after staying up and fatiguing, and visits other doctors to make a paste of traditional Chinese medicine 7,

cortex Phellodendri 10g, herba Menthae 12g, glycyrrhrizae radix 6g, herba Centellae 10g, rhizoma Smilacis Glabrae 15g, radix Angelicae Dahuricae 12g, herba Eupatorii 12g, radix Codonopsis 12g, poria 12g, atractylodis rhizoma 15g, rhizoma Atractylodis 12g, coicis semen 30g

Poor curative effect, no improvement of oral cavity, obvious pain, cold feeling, fatigue, stay up, pale and tender tongue, white fur, side teeth marks, red tip and weak pulse, and seven patches of traditional Chinese medicine are given to patients for diagnosing at my places again,

15g of radix pseudostellariae, 15g of poria cocos, 12g of fried white atractylodes rhizome, 6g of fried white peony root, 9g of ginger processed pinellia, 9g of fried baikal skullcap root, 12g of cassia twig, wen Shanyao g of cornus officinalis, 9g of medicinal cyathula root, 10g of malaytea scurfpea fruit, 9g of wild jujube seed, 15g of Chinese white 9g of kudzuvine root, 30g of divaricate saposhnikovia root, 9g of coptis root, 3g of turmeric root-tuber, 10g of turmeric root-tuber, 12g of silktree albizia bark

The patient feels that the pain at the ulcer is improved the second day after taking the medicine, the dental ulcer is basically relieved three days after taking the medicine, and the patient does not relapse after taking the medicine seven days.

The present invention is not limited to the above embodiments, but is capable of modification and variation in detail, and other modifications and variations can be made by those skilled in the art without departing from the scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating recurrent oral ulcer is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by mass:

2. The use of the Chinese medicinal composition according to claim 1 for preparing a medicament for treating recurrent oral ulcer.

3. The use of the traditional Chinese medicine composition according to claim 1 in the preparation of a medicament for treating recurrent oral ulceration, characterized in that: the composition is used for preparing medicines for treating recurrent oral ulcer with symptoms of vexation, irritability, aversion to cold, cold limbs and loose stool.