CN115068538A - Premna microphylla extract with constipation relieving function - Google Patents
Premna microphylla extract with constipation relieving function Download PDFInfo
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- CN115068538A CN115068538A CN202210836884.9A CN202210836884A CN115068538A CN 115068538 A CN115068538 A CN 115068538A CN 202210836884 A CN202210836884 A CN 202210836884A CN 115068538 A CN115068538 A CN 115068538A
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- 241000531314 Premna microphylla Species 0.000 title claims abstract description 87
- 239000000284 extract Substances 0.000 title claims abstract description 58
- 206010010774 Constipation Diseases 0.000 title claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 230000002040 relaxant effect Effects 0.000 claims abstract description 10
- 239000006286 aqueous extract Substances 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 230000002195 synergetic effect Effects 0.000 claims abstract description 5
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 4
- 235000019441 ethanol Nutrition 0.000 claims description 13
- 239000000469 ethanolic extract Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000009210 therapy by ultrasound Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000005764 inhibitory process Effects 0.000 abstract description 17
- 238000012360 testing method Methods 0.000 abstract description 16
- 230000000968 intestinal effect Effects 0.000 abstract description 11
- 230000008855 peristalsis Effects 0.000 abstract description 11
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 abstract description 9
- 229960001571 loperamide Drugs 0.000 abstract description 9
- 230000013872 defecation Effects 0.000 description 18
- 239000000976 ink Substances 0.000 description 8
- 239000002245 particle Substances 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000862992 Chondromyces Species 0.000 description 2
- 241000522190 Desmodium Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Botany (AREA)
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Abstract
The invention provides a Premna microphylla extract with a bowel relaxing function, which is prepared by mixing a Premna microphylla alcohol extract and a Premna microphylla water extract according to a specific weight ratio. The premna microphylla leaf ultrafine powder is used as a raw material of the premna microphylla alcohol extract, ethanol is used as an extractant, vacuum synergistic ultrasonic extraction is carried out at the temperature of 25 ℃, and the extract is prepared by concentration and drying; the premna microphylla aqueous extract is prepared by using defatted premna microphylla leaf superfine powder as a raw material and water as an extracting agent, performing vacuum synergistic ultrasonic extraction at 80 ℃, and concentrating and drying an extracting solution. The premna microphylla extract prepared by the invention is verified by a mouse living body test, can obviously improve the intestinal peristalsis inhibition induced by loperamide and has the function of relaxing bowels.
Description
Technical Field
The invention belongs to the technical field of functional food development, and particularly relates to a premna microphylla extract with a constipation relieving function.
Technical Field
The premna microphylla leaf is rich in nutrition, is rich in various bioactive components such as dietary fiber, pectin, polyphenol, flavone and the like, and has high development and utilization values. In recent years, with the continuous expansion of the planting area of premna microphylla in China, the yield of premna microphylla leaves increases year by year, and various processed products taking premna microphylla leaves as raw materials are on the rise, but at present, the processed premna microphylla leaves are mainly low-end products, have low additional value, and greatly limit the development of premna microphylla industry.
In order to solve the problem of low added value of products in the existing Premna microphylla industry and promote the development of the Premna microphylla industry, the invention develops the Premna microphylla extract with the function of relaxing the bowels by taking Premna microphylla leaves as raw materials.
Disclosure of Invention
The invention provides a premna microphylla extract with a function of relaxing bowels, which consists of premna microphylla alcohol extract and premna microphylla water extract according to a specific weight ratio. The premna microphylla extract prepared by the invention is verified by a mouse living body test, can obviously improve the intestinal peristalsis inhibition induced by loperamide and has the function of relaxing bowels.
The method comprises the following concrete implementation steps:
1. the preparation of the premna microphylla alcohol extract comprises the following steps: taking superfine powder of premna microphylla leaves as a raw material, taking absolute ethyl alcohol as an extracting agent, and performing ultrasonic treatment under the conditions that the vacuum degree is 0.1Mpa, the ultrasonic power is 300W, the temperature is 25 ℃, the material-liquid ratio is 1: extracting under vacuum and ultrasonic conditions for 60min under 50 deg.C, concentrating the extractive solution, and drying to obtain Premna microphylla alcohol extract;
2. preparing the aqueous extract of premna microphylla: taking degreased premna microphylla leaf superfine powder as a raw material and pure water as an extracting agent, and performing ultrasonic treatment under the conditions that the vacuum degree is 0.1Mpa, the ultrasonic power is 300W, the temperature is 80 ℃, and the material-liquid ratio is 1: extracting under vacuum and ultrasonic conditions for 60min under 50 deg.C, concentrating the extractive solution, and drying to obtain Premna microphylla aqueous extract;
3. preparing the premna microphylla extract: mixing the premna microphylla ethanol extract and the premna microphylla water extract according to the ratio of 1-7: and 7-15, and uniformly mixing to obtain the premna microphylla extract.
The beneficial technical effects of the invention are as follows: the alcohol-soluble components and the water-soluble components in the premna microphylla leaves are respectively extracted, then the alcohol extract and the water extract are reasonably combined according to a specific weight proportion to prepare the premna microphylla extract, and the verification of a mouse living body test shows that the combined premna microphylla alcohol extract and premna microphylla water extract have a synergistic effect on improving the inhibition of the intestinal peristalsis induced by the loperamide, can obviously improve the inhibition of the intestinal peristalsis induced by the loperamide and have an obvious function of relaxing the bowels.
Detailed Description
The present invention is further illustrated by the following specific examples. The features and advantages of the present invention will become more apparent as the description proceeds, but the exemplary embodiments are merely illustrative of the present invention and do not set any limit to the scope of the present invention.
Example 1
1. The preparation of the premna microphylla alcohol extract comprises the following steps: taking superfine premna microphylla leaves powder as a raw material, taking absolute ethyl alcohol as an extracting agent, and carrying out ultrasonic treatment under the conditions that the vacuum degree is 0.1Mpa, the ultrasonic power is 300W, the temperature is 25 ℃, and the material-liquid ratio is 1: performing vacuum synergistic ultrasonic extraction for 60min under the condition of 50, and concentrating and drying an extracting solution to obtain the premna microphylla ethanol extract;
2. preparing the aqueous extract of premna microphylla: taking degreased premna microphylla leaf superfine powder as a raw material and pure water as an extracting agent, and performing ultrasonic treatment under the conditions that the vacuum degree is 0.1Mpa, the ultrasonic power is 300W, the temperature is 80 ℃, and the material-liquid ratio is 1: extracting under vacuum and ultrasonic conditions for 60min under 50 deg.C, concentrating the extractive solution, and drying to obtain Premna microphylla aqueous extract;
3. preparing a Premna microphylla extract: mixing the premna microphylla ethanol extract and the premna microphylla water extract according to the ratio of 1-7: and 7-15, and uniformly mixing to obtain the premna microphylla extract.
4. The method for measuring the defaecation function of the Premna microphylla extract comprises the following specific steps:
(1) grouping tests: the catharsis function determination of the premna microphylla extract takes adult male Kunming mice as test animals, and the test animals are divided into 5 groups, namely a normal control group, an intestinal peristalsis inhibition model group, a premna microphylla alcohol extract group, a premna microphylla water extract group and a premna microphylla extract group.
(2) The test method comprises the following steps: referring to the defecation function test method in the 'health food test and evaluation technical specification', a normal control group and an enterokinesia inhibition model group are filled with stomach distilled water, a premna microphylla alcohol extract group, a premna microphylla water extract group and a premna microphylla extract group are filled with stomach premna microphylla alcohol extract, a premna microphylla water extract and a premna microphylla extract respectively according to the dosage of 700mg/kg/d, after the stomach is filled for 7d, mice of each test group are fasted and are not forbidden to drink for 16h, an enterokinesia inhibition model group, a premna microphylla alcohol extract group, a premna microphylla water extract group and a premna microphylla extract group adopt loperamide as a model-making medicine to establish a mouse enterokinesia inhibition model (the dosage of an ink propulsion rate test is 5mg/kg, the dosage of loperamide test is 10mg/kg), and the stomach distilled water is filled in the normal control group, and the ink propulsion rate, the defecation time and the number of particles are 5h are filled with the ink propulsion rate, The defecation weight of 5h is taken as a measurement index.
(3) And (3) test results: the results of the bowel relaxing index measurements for each test group are shown in Table 1.
TABLE 1 results of the bowel relaxing index measurement for each test group
| Grouping | Propelling rate of ink% | Defecation time min | Number of particles for 5h defecation | Weight g of defecation 5h |
| Normal control group | 70.67±5.78 b | 109.11±11.31 bc | 59.36±8.51 b | 1.19±0.17 b |
| Intestinal motility inhibition model group | 45.02±6.72 ac | 179.67±10.32 ac | 21.13±4.43 ac | 0.45±0.09 ac |
| Premna microphylla alcohol extract group | 45.77±6.68 ac | 178.15±9.97 ac | 22.03±8.92 ac | 0.47±0.13 ac |
| Premna microphylla water extract group | 56.72±7.99 abc | 144.63±11.09 abc | 30.71±7.12 abc | 0.66±0.21 abc |
| Premna microphylla extract group | 69.91±6.54 b | 117.81±8.91 ab | 57.93±6.98 b | 1.15±0.11 b |
Note: a compared with a normal control group, the composition has significant difference, b compared with the intestinal peristalsis inhibition model group, the method has significant difference, c compared with the premna microphylla extract group, the premna microphylla extract group has significant difference, and P is less than 0.05.
The result of the bowel relaxing function measurement shows that: the ink propulsion rate, the number of particles in 5h defecation and the defecation weight in 5h of the enterokinesia inhibition model group are obviously smaller than those of the normal control group, and the black defecation time is obviously longer than that of the normal control group, so that the success of establishing an enterokinesia inhibition model by using loperamide is shown; the four indexes of the Chinese ink propulsion rate, the black defecation time, the defecation particle number in 5h and the defecation weight in 5h of the mice in the stomach-perfused desmodium polycephalum ethanol extract test group have no significant difference with the intestinal peristalsis inhibition model group, which indicates that the intestinal peristalsis inhibition induced by loperamide cannot be improved by the stomach-perfused desmodium polycephalum ethanol extract alone; the four indexes of the Chinese ink propulsion rate, the black defecation time, the defecation particle number in 5h and the defecation weight in 5h of the mice in the stomach-perfused premna microphylla aqueous extract test group are obviously different from those of the intestinal peristalsis inhibition model group and the normal control group, which shows that the intestinal peristalsis inhibition induced by loperamide can be improved to a certain degree by the single stomach-perfused premna microphylla aqueous extract group, but the improvement effect is limited; compared with the intestinal peristalsis inhibition model group, the four indexes of the Chinese ink propulsion rate, the defecation time, the defecation particle number for 5h and the defecation weight for 5h of the mice in the stomach-perfused premna microphylla extract test group are all significantly different, and compared with the premna microphylla water extract group, the four indexes are superior to the premna microphylla water extract group and significantly different.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that the content of the present invention can be modified and modified by those skilled in the art without departing from the technical principle of the present invention, and the modified and modified are also considered to be the protection scope of the present invention.
Claims (2)
1. A Premna microphylla extract with a constipation relieving function, which is characterized by comprising: 1-7 parts of the premna microphylla alcohol extract and 7-15 parts of the premna microphylla water extract.
2. The method for preparing the Premna microphylla extract with the function of relaxing bowels according to claim 1, which comprises the steps of:
(1) the preparation of the premna microphylla alcohol extract comprises the following steps: taking superfine premna microphylla leaves powder as a raw material, taking absolute ethyl alcohol as an extracting agent, and carrying out ultrasonic treatment under the conditions that the vacuum degree is 0.1Mpa, the ultrasonic power is 300W, the temperature is 25 ℃, and the material-liquid ratio is 1: performing vacuum synergistic ultrasonic extraction for 60min under the condition of 50, and concentrating and drying an extracting solution to obtain the premna microphylla ethanol extract;
(2) preparing the aqueous extract of premna microphylla: taking degreased premna microphylla leaf superfine powder as a raw material and pure water as an extracting agent, and performing ultrasonic treatment under the conditions that the vacuum degree is 0.1Mpa, the ultrasonic power is 300W, the temperature is 80 ℃, and the material-liquid ratio is 1: extracting under vacuum and ultrasonic conditions for 60min under 50 deg.C, concentrating the extractive solution, and drying to obtain Premna microphylla aqueous extract;
(3) preparing a Premna microphylla extract: mixing the premna microphylla ethanol extract and the premna microphylla water extract according to the ratio of 1-7: and 7-15, and uniformly mixing to obtain the premna microphylla extract.
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|---|---|---|---|
| CN202210836884.9A CN115068538B (en) | 2022-07-15 | 2022-07-15 | Premna microphylla extract with constipation relieving function |
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| CN202210836884.9A CN115068538B (en) | 2022-07-15 | 2022-07-15 | Premna microphylla extract with constipation relieving function |
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| CN115068538B CN115068538B (en) | 2023-06-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116671635A (en) * | 2023-07-05 | 2023-09-01 | 合肥膳之纤生物科技有限公司 | Functional food with constipation relieving effect |
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| CN112754955A (en) * | 2021-02-07 | 2021-05-07 | 西南大学 | Premna microphylla pectin mask liquid and preparation method thereof |
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2022
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| CN106106958A (en) * | 2016-08-29 | 2016-11-16 | 杨兴才 | A kind of preparation method of Herba Premnae Microphyllae health tea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116671635A (en) * | 2023-07-05 | 2023-09-01 | 合肥膳之纤生物科技有限公司 | Functional food with constipation relieving effect |
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