CN115054796A - Device and method for acting on brain by using infrasonic wave neurological effect - Google Patents

Device and method for acting on brain by using infrasonic wave neurological effect Download PDF

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CN115054796A
CN115054796A CN202210606002.XA CN202210606002A CN115054796A CN 115054796 A CN115054796 A CN 115054796A CN 202210606002 A CN202210606002 A CN 202210606002A CN 115054796 A CN115054796 A CN 115054796A
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brain
infrasonic
electroencephalogram
infrasound
neurological
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CN115054796B (en
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秦杨
郁可
杨晓鲲
杨婷
马利红
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Western Theater General Hospital of PLA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A61M2021/0033Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense subsonic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/08Other bio-electrical signals
    • A61M2230/10Electroencephalographic signals

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Abstract

The invention belongs to the technical field of nerve treatment equipment, and discloses a device and a method for acting on the brain by using infrasonic wave neurological effect, wherein the device comprises headgear equipment and a host connected with the headgear equipment through a signal cable; the head cover equipment is provided with 8 infrasound speakers and electroencephalogram electrodes, and the infrasound speakers and the electroencephalogram electrodes are respectively used for realizing the functions of infrasound output and electroencephalogram input; the host consists of a charging power supply system, an information input and state display interface, a preset program storage and controller, a microprocessor, an electroencephalogram receiving and analyzing system, a microprocessor and an infrasound signal generator; the information input and state display interface is connected with the preset program storage and controller, and the microprocessor is respectively connected with the preset program storage and controller, the electroencephalogram receiving and analyzing system and the infrasound signal generator.

Description

Device and method for acting on brain by using infrasonic wave neurological effect
Technical Field
The invention belongs to the technical field of nerve treatment equipment, and particularly relates to a device and a method for acting on the brain by using infrasonic wave neurological effect.
Background
Infrasonic waves are mechanical waves with frequencies below 20Hz, where infrasonic waves with emission frequencies of 8-12 Hz can cause brain tissue resonances, known as neural infrasound. Research shows that infrasonic waves with long time and high sound pressure level (more than 90db) can cause damage to organisms, wherein the nervous system is the most sensitive; the infrasonic waves with low sound pressure level can generate beneficial neurological effect through slight resonance with brain tissues, and can generate positive effect on brain trauma, cerebral ischemia and anoxia, neuropsychological problems and the like. The mechanism may include: (1) regulating nerve cell signal conduction path to inhibit neuron degeneration and promote axon growth; (2) the nerve stimulation device has the effects of improving the nerve paralysis state and negative emotion by stimulating nerves to regulate calcium ion channels, sensitizing proprioception and exciting vagus nerves; (3) the connection and the loop function between nerve cells are promoted through the rhythmic concussion stimulation, the neuropathic pain and severe anxiety can be relieved, and the cognitive function is promoted; (4) the cerebral metabolic waste and harmful substances in the brain are removed quickly by promoting the circulation of cerebrospinal fluid; (5) by inducing the rhythm change of the brain electricity, the brain electricity generates a synchronization effect, the main rhythm of the brain electricity of an organism can be obviously adjusted, the physiological activity state of the brain of the organism can be changed, and insomnia, mental diseases, mental fatigue and the like can be improved.
In the prior art, patent document No. CN113577498A provides a composite brain wave-induced sleep-assisting pillow and a brain wave-induced modulation method, which includes a pillow body, an inflatable pillow core, a microprocessor, a controller, a sleep state sensor, an audio player and a power supply; the pillow body is provided with an opening; the inflatable pillow core is provided with an air release valve and a pressing inflator pump; the audio player can play audio from infrasonic waves to ultrasonic waves; the microprocessor can generate audio frequency from infrasonic wave audio frequency to ultrasonic wave by frequency modulation of the induced brain wave; the brain wave induction modulation method mixes and modulates the selected sleep-aiding music and a plurality of brain waves of each sleep stage, including a first stage (falling sleep stage), a second stage (light sleep stage), a third stage (sound sleep stage) and a fourth stage (deep sleep stage); automatically selecting a corresponding brain wave modulation method by detecting the feedback of the sleep state sensor; the brain wave signals after modulation and frequency modulation are sent to an audio player; through the gradual induction of brain waves, the insomniac gradually enters a deep sleep stage.
In the patent document with patent number CN104436407A in the prior art, an infrasonic wave fatigue relieving method and device are provided, the fatigue relieving method is that infrasonic waves are used to induce brain waves to make the brain rapidly enter a deep sleep state, and the brain waves are delta rhythm waves at the moment, so that the blood oxygen of the brain of a human is supplemented, the body tension state is relaxed, the physical strength is recovered, and fatigue is relieved; the device for relieving the fatigue comprises a cabin cover, a control system, a hydraulic system, a power amplifier, a guide rail, a bed body, a loudspeaker, a control panel, a lighting system, a cabin body and the like, a full-closed, full-automatic and noiseless design is adopted, and multiple input modes are built in infrasonic wave input signals, so that the device is suitable for people of different ages and different requirements.
Although sound waves above the auditory threshold in the prior art have a certain sleep-aiding effect, the inner ear can continuously convert sound signals into nerve signals and transmit the nerve signals to the brain because the frequency and the sound intensity of the sound waves are above the auditory threshold. This not only causes hearing impairment, but may also interfere with normal sleep architecture, affecting cognitive function, and may lead to impaired heart health over the long term. Mechanical equipment such as a massage pillow can relieve local muscle tension to achieve the purpose of relaxation, but cannot realize the neurological effect of infrasonic waves.
Through the above analysis, the problems and defects of the prior art are as follows:
(1) sound wave helps dormancy equipment among the prior art receives signal transmission through the people's ear, and long-term the use can arouse hearing damage, still can disturb normal sleep structure, influences cognitive function, still can lead to the heart health impaired for a long time. In addition, this approach does not act directly on the brain tissue, in contrast to the direct action of the frontal, parietal, occipital and temporal lobes provided by the present invention through infrasonic penetration of the skull.
(2) Mechanical devices such as "massage pillows" can relieve local muscle tension to achieve relaxation, but cannot achieve the neurological effect of infrasonic waves.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a device and a method for acting on the brain by utilizing infrasonic neurological effect.
The present invention is achieved by an apparatus for acting on the brain using infrasonic neurological effects, comprising:
the headset comprises a headset device and a host connected with the headset device through a signal cable;
the head cover equipment is provided with 8 infrasound speakers and electroencephalogram electrodes, and the infrasound speakers and the electroencephalogram electrodes are respectively used for realizing the functions of infrasound output and electroencephalogram input;
the host consists of a charging power supply system, an information input and state display interface, a preset program storage and controller, a microprocessor, an electroencephalogram receiving and analyzing system, a microprocessor and an infrasound signal generator;
the information input and state display interface is connected with the preset program storage and controller, and the microprocessor is respectively connected with the preset program storage and controller, the electroencephalogram receiving and analyzing system and the infrasound signal generator.
Furthermore, brain wave signal entry and sound wave signal export are connected with respectively to brain wave receiving analysis system and infrasound signal generator, brain wave signal entry and sound wave signal export are connected with headgear equipment through interconnecting link respectively.
Further, the host computer outside is provided with voice prompt loudspeaker and operation pilot lamp group, voice prompt loudspeaker and operation pilot lamp group are connected with microprocessor through interconnecting link respectively.
It is another object of the present invention to provide a method for acting on the brain using an infrasonic neurological effect, the method for acting on the brain using an infrasonic neurological effect comprising:
firstly, adjusting a loudspeaker and an electrode position with a head sleeve to correspond to a good brain area, and connecting a cable between the head sleeve and a host;
turning on a power supply, inputting personnel information, selecting a corresponding preset program scheme, and starting the device;
step three, the language guide enters a sitting or semi-sleeping state, and infrasound signals are output according to a preset program;
step four, monitoring the brain electricity for 5 minutes, finishing subsequent treatment according to a program after the brain electricity is confirmed to meet the target, shutting down the machine, and taking down the headgear.
Furthermore, a head sleeve is arranged in the step of adjusting the positions of the loudspeaker and the electrode to correspond to the positions of the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe of two cerebral hemispheres of the human body.
And further, when the target electroencephalogram is determined to be met in the fourth step, if the target electroencephalogram is not met, the output parameters are automatically fine-tuned, and the third step is returned.
Further, the range of action of the method of using infrasonic neurological effects on the brain includes the following pathological states: anxiety states, depressive states, sleep disorders, primary cognitive dysfunction, and recovery from brain injury.
Furthermore, the method for acting on the brain by using the infrasonic neurological effect sets different infrasonic output parameters according to different infrasonic neurological effect principles.
Further, the infrasound output parameters include: brain area stimulation, sound intensity, frequency conversion, and action time.
Further, the evaluation index of the effect of the method for acting on the brain using the infrasonic neurological effect includes: brain wave morphology, objective scale, and subjective symptoms.
In combination with the technical solutions and the technical problems to be solved, please analyze the advantages and positive effects of the technical solutions to be protected in the present invention from the following aspects:
first, aiming at the technical problems existing in the prior art and the difficulty in solving the problems, the technical problems to be solved by the technical scheme of the present invention are closely combined with the technical scheme to be protected and the results and data in the research and development process, and some creative technical effects brought after the problems are solved are analyzed in detail and deeply. The specific description is as follows:
the invention designs a related device acting on the head under the condition of limiting the safe sound pressure level, and infrasonic waves penetrate through the skull (not through the auditory organ) to generate concussion with different intensity, rhythm and action time on brain tissues, so that the related device can adjust the neuropsychological problems such as sleep disorder, anxiety and depression, and the like, and the pathological states of nerve injury such as cognitive disorder, brain injury recovery period and the like. Different infrasonic wave mode outputs and fine adjustment can be implemented according to different disease states, such as anxiety states, depression states, sleep disorders, primary cognitive dysfunction and brain injury recovery periods, and brain wave detection real-time monitoring results, and the infrasonic wave mode finally acts on the brain to realize beneficial neurological effects and assist in improving objective indexes and subjective symptoms of pathological states.
Secondly, considering the technical scheme as a whole or from the perspective of products, the technical effect and advantages of the technical scheme to be protected by the invention are specifically described as follows:
in the aspect of neuropsychological problems, the invention shortens the time of falling asleep, prolongs the sleep time limit and prolongs the deep sleep time for insomnia. The objective of reducing subjective discomfort symptoms and decreasing relevant scale scores is achieved for patients with anxiety or depression.
The present invention promotes recovery of nerve function from the aspects of inhibiting neuronal degeneration, promoting axonal growth, and increasing IL-6, IGF-1 and GFAP expression, etc., after neurodegeneration (cognitive dysfunction) and brain injury.
Third, as an inventive supplementary proof of the claims of the present invention, there are also presented several important aspects:
(1) the expected income and commercial value after the technical scheme of the invention is converted are as follows:
anxiety, depression and sleep disorders seriously jeopardize the physical and mental health of people, with an overall incidence rate close to 40%. Primary cognitive dysfunction, represented by alzheimer's disease, is a major threat to the elderly population. Brain injury (traumatic) is an important killer for causing disability in young adults. The technical scheme of the invention has huge application range and commercial value after conversion.
(2) The technical scheme of the invention fills the technical blank in the industry at home and abroad:
currently, the treatment measures for neuropsychological problems such as anxiety and depression include: drug therapy, psychological intervention, transcranial magnetic stimulation, electrical convulsion and the like. No device or technical solution for acting on the above-mentioned diseases by using the infrasonic neurological effect has been reported. On the basis of deeply analyzing relevant basic research of low-sound-pressure-level infrasound waves in the field of neurology, the invention provides a feasible technical solution for utilizing beneficial neurological effects of infrasound, and fills technical gaps in domestic and foreign industries.
(3) The technical scheme of the invention solves the technical problems which are always desired to be solved but are not successful:
the biological principle on which the invention is based mainly comes from animal experiments and basic research, and experimental research of therapeutic intervention by infrasonic wave acting on brain tissue in human bodies is not seen, so that no related technical scheme is seen. The invention provides a feasible way for developing human body tests on the premise of meeting ethical requirements.
(4) The technical scheme of the invention overcomes the technical prejudice that:
infrasonic waves are generally considered as physical factors harmful to human bodies, and for example, the low-frequency noise and infrasonic waves exposed to the environment for a long time can cause the health problems of dysphoria, sleeping problems, inattention, headache, cognitive impairment, even brain structure change and the like of residents. In the health field, attention is paid to prevention of damage of infrasound to human bodies, and although basic research supports that infrasound at low sound pressure level can generate beneficial neurological effects, no auxiliary treatment technical scheme that infrasound penetrates through skull and directly acts on human brain tissue is developed and used so far.
Drawings
FIG. 1 is a schematic structural diagram of an apparatus for affecting the brain using infrasonic neurological effects according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of an apparatus for applying infrasonic neurological effects to the brain according to an embodiment of the present invention;
FIG. 3 is a flow chart of a method for using infrasonic neurological effects to affect the brain according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of the method of using infrasonic neurological effects to affect the brain according to the present invention;
in the figure: 1. a headgear; 2. a host; 3. a voice prompt loudspeaker; 4. operating the indicator light set; 5. brain wave signal entrance; 6. an acoustic signal outlet; 7. infrasound speaker and brain electricity electrode assembly.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
First, an embodiment is explained. This section is an explanatory embodiment expanding on the claims so as to fully understand how the present invention is embodied by those skilled in the art.
As shown in fig. 1 and 2, the apparatus for applying infrasonic neurological effect to the brain provided by the embodiment of the present invention comprises: the headset comprises a headset 1 and a host machine 2 connected with the headset 1 through a signal cable;
the head sleeve 1 is provided with 8 infrasound speakers and electroencephalogram electrode assemblies 7, and the infrasound speakers and the electroencephalogram electrodes are respectively used for realizing the functions of infrasound output and electroencephalogram input;
the host 2 consists of a charging power supply system, an information input and state display interface, a preset program storage and controller, a microprocessor, an electroencephalogram receiving and analyzing system, a microprocessor and an infrasound signal generator;
the information input and state display interface is connected with the preset program storage and controller, and the microprocessor is respectively connected with the preset program storage and controller, the electroencephalogram receiving and analyzing system and the infrasound signal generator. The electroencephalogram receiving and analyzing system and the infrasound signal generator are respectively connected with a brain wave signal inlet 5 and a sound wave signal outlet 6, and the brain wave signal inlet 5 and the sound wave signal outlet 6 are respectively connected with the headgear equipment through connecting lines.
The voice prompt loudspeaker 3 and the operation indicator lamp set 4 are arranged on the outer side of the host machine in the embodiment of the invention and are respectively connected with the microprocessor through connecting lines.
As shown in fig. 3, the method for acting on the brain using the infrasonic neurological effect in the embodiment of the present invention includes:
firstly, adjusting a infrasound loudspeaker and electroencephalogram electrode assembly to correspond to a brain area by a head sleeve, and connecting a cable between the head sleeve and a host;
turning on a power supply, inputting personnel information, selecting a corresponding preset program scheme, and starting the device;
step three, the language guide enters a sitting or semi-sleeping state, and infrasound signals are output according to a preset program;
and fourthly, monitoring the electroencephalogram for 5 minutes, finishing subsequent treatment according to a program after the electroencephalogram meets the target electroencephalogram, and shutting down and taking down the headgear.
In the embodiment of the invention, the infrasound loudspeaker and the electroencephalogram electrode assembly in the step one correspond to the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe of two cerebral hemispheres of a human body respectively.
If the target electroencephalogram is determined to be met in the fourth step, the output parameters are automatically fine-tuned, and the third step is returned.
The scope of action of the present invention mainly includes the following pathological states: anxiety states, depressive states, sleep disorders, primary cognitive dysfunction, and convalescent phases of brain injury.
Starting from different infrasound neurological effect principles, different infrasound output parameters are set, and the method mainly comprises the following steps: stimulating brain region, sound intensity, frequency conversion, action time; the effectiveness evaluation indexes include: brain wave morphology, objective scale and subjective symptoms as shown in fig. 4.
And II, application embodiment. In order to prove the creativity and the technical value of the technical scheme of the invention, the part is the application example of the technical scheme of the claims on specific products or related technologies.
The technical scheme is not applied to the embodiment of a human body for a moment, and the technical principle is mainly based on the basic research of animal experiments. The review "positional Mechanisms for the Effects of Sound scattering on Human health, health (Basel) 2021.9 (5)" summarizes the Possible biological Mechanisms by which low frequency Sound waves (including infrasound waves) produce neurological Effects.
And thirdly, evidence of relevant effects of the embodiment. The embodiment of the invention achieves some positive effects in the process of research and development or use, and has great advantages compared with the prior art, and the following contents are described by combining data, diagrams and the like in the test process.
There is no evidence of the effect of the relevant examples in humans, and based on animal experimental studies, the following effects are: regulating nerve cell signal conduction path to inhibit neuron degeneration and promote axon growth; the nerve stimulation device has the effects of improving the nerve paralysis state and negative emotion by stimulating nerves to regulate calcium ion channels, sensitizing proprioception and exciting vagus nerves; the connection and the loop function between nerve cells are promoted through the rhythmic concussion stimulation, the neuropathic pain and severe anxiety can be relieved, and the cognitive function is promoted; promote the expression of IL-6, IGF-1 and GFAP in the brain to be obviously increased, and can play a role in protecting the brain damage caused by trauma, ischemia and hypoxia.
The above description is only for the purpose of illustrating the present invention and the appended claims are not to be construed as limiting the scope of the invention, which is intended to cover all modifications, equivalents and improvements that are within the spirit and scope of the invention as defined by the appended claims.

Claims (10)

1. An apparatus for acting on the brain using an infrasonic neurological effect, said apparatus comprising:
the headset comprises a headset device and a host connected with the headset device through a signal cable;
the head cover equipment is provided with 8 infrasound speakers and electroencephalogram electrodes, and the infrasound speakers and the electroencephalogram electrodes are respectively used for realizing the functions of infrasound output and electroencephalogram input;
the host consists of a charging power supply system, an information input and state display interface, a preset program storage and controller, a microprocessor, an electroencephalogram receiving and analyzing system, a microprocessor and an infrasound signal generator;
the information input and state display interface is connected with the preset program storage and controller, and the microprocessor is respectively connected with the preset program storage and controller, the electroencephalogram receiving and analyzing system and the infrasound signal generator.
2. The apparatus according to claim 1, wherein said electroencephalogram receiving and analyzing system and said infrasonic signal generator are connected to a brain wave signal inlet and a sonic signal outlet, respectively, and said brain wave signal inlet and said sonic signal outlet are connected to said headgear device through connecting lines, respectively.
3. The apparatus according to claim 1, wherein said main body is provided with a voice speaker and an operation indicator lamp set at the outside thereof, said voice speaker and operation indicator lamp set being connected to said microprocessor through connecting lines, respectively.
4. A method of applying an infrasonic neurological effect to a brain for implementing the apparatus for applying an infrasonic neurological effect to a brain according to any one of claims 1 to 3, wherein the method of applying an infrasonic neurological effect to a brain comprises:
firstly, adjusting a loudspeaker and an electrode position with a head sleeve to correspond to a good brain area, and connecting a cable between the head sleeve and a host;
turning on a power supply, inputting personnel information, selecting a corresponding preset program scheme, and starting the device;
step three, the language guide enters a sitting or semi-sleeping state, and infrasound signals are output according to a preset program;
and fourthly, monitoring the electroencephalogram for 5 minutes, finishing subsequent treatment according to a program after the electroencephalogram meets the target electroencephalogram, and shutting down and taking down the headgear.
5. The method of claim 4 wherein a cuff is provided to adjust the position of the speaker and the electrodes to correspond to the frontal, parietal, temporal and occipital lobes of the two hemispheres of the human body in the area of the brain.
6. The method of claim 4, wherein when the target brain wave is determined to be met in the fourth step, the output parameters are automatically adjusted to the third step if the target brain wave is not met.
7. The method of using infrasonic neurological effects to affect the brain according to claim 4 wherein the range of action of said method of using infrasonic neurological effects to affect the brain includes the following pathological states: anxiety states, depressive states, sleep disorders, primary cognitive dysfunction, and recovery from brain injury.
8. The method of utilizing an infrasonic neurological effect to affect the brain according to claim 4 wherein said method of utilizing an infrasonic neurological effect to affect the brain sets different infrasonic output parameters based on different principles of infrasonic neurological effects.
9. The method of utilizing infrasonic neurological effects in the brain of claim 8 wherein the infrasonic output parameters include: stimulating brain region, sound intensity, frequency conversion, and action time.
10. The method of claim 4, wherein the evaluation of the effect of the method of using an infrasonic neurological effect on the brain comprises: brain wave morphology, objective scale, and subjective symptoms.
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