CN1150541A - Spray containing diclofenac sodium - Google Patents
Spray containing diclofenac sodium Download PDFInfo
- Publication number
- CN1150541A CN1150541A CN 95112225 CN95112225A CN1150541A CN 1150541 A CN1150541 A CN 1150541A CN 95112225 CN95112225 CN 95112225 CN 95112225 A CN95112225 A CN 95112225A CN 1150541 A CN1150541 A CN 1150541A
- Authority
- CN
- China
- Prior art keywords
- diclofenac sodium
- sodium
- tween
- propylene glycol
- spray containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960001193 diclofenac sodium Drugs 0.000 title claims abstract description 22
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 title claims abstract description 22
- 239000007921 spray Substances 0.000 title claims abstract description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 32
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims abstract description 22
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 11
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 11
- 235000010265 sodium sulphite Nutrition 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000012153 distilled water Substances 0.000 claims abstract description 8
- 210000000214 mouth Anatomy 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 5
- -1 Oleum menthae Chemical compound 0.000 claims description 3
- 244000246386 Mentha pulegium Species 0.000 claims description 2
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 2
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 2
- 201000007100 Pharyngitis Diseases 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims description 2
- 235000001050 hortel pimenta Nutrition 0.000 claims description 2
- 239000002075 main ingredient Substances 0.000 claims description 2
- 206010044008 tonsillitis Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 235000011187 glycerol Nutrition 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 230000007794 irritation Effects 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 abstract 1
- 235000019477 peppermint oil Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000004907 gland Anatomy 0.000 description 3
- 206010065716 Pharyngeal inflammation Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229960001859 domiphen bromide Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 229940100050 virazole Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a diclofenac sodium spray. Its main composition includes (wt%) diclofenac sodium 0.5-2, propylene glycol 5-15, Tween-80 0-3, glycerine 1-8, peppermint oil 0.1-0.8, sodium sulfite 0-0.1 and distilled water 80-90. Said invention can be directly applied to affected region of various inflammations in oral cavity, and features high local drug concentration, quick absorption, fast obtaining result, good oral feeling, no irritation, convenient in application, and stable in product quality.
Description
The present invention relates to a kind of spray containing diclofenac sodium, belong to the Western medicine preparation technical field.
Various inflammation are common clinical, frequently-occurring disease in the oral cavity, mainly are owing to streptococcus, viral infection cause.That this disease causes is pharyngeal, oral cavity pain unbearably, influence people's orthobiosis.At present the main medicine that clinical treatment should disease is the domiphen bromide, virazole, Herba Pileae Scriptae of buccal etc., Perorally administrable antimicrobial sulfonamides etc., and said medicine mainly is based on anti-inflammation, onset is slower, eliminate pain rapidly, minimizing patient misery.
The objective of the invention is at the problems referred to above, provide a kind of energy quick eliminate pain, reduce the oral cavity and the pharyngeal inflammation treatment medication spray containing diclofenac sodium of patient's misery.
Technical characterstic of the present invention is that to have selected propylene glycol, tween 80, glycerol for use be hydrotropy, helps absorbent, distilled water is a primary solvent, and diclofenac sodium is dissolved in this type of mixed solvent, can improve infiltration rate and absorbtivity at medicine-feeding part, Oleum menthae is a correctives, and sodium sulfite is an antioxidant.
Spray containing diclofenac sodium of the present invention is to realize like this, its Main Ingredients and Appearance comprises diclofenac sodium, propylene glycol, glycerol, tween 80, Oleum menthae, sodium sulfite and distilled water, the percentage by weight of each composition are diclofenac sodium 0.5-2, propylene glycol 5-15, tween 80 0-3, glycerol 1-8, Oleum menthae 0.1-0.8, sodium sulfite 0-0.1, distilled water 80-90.The present invention is in the clinical treatment that is mainly used in oral cavity pharyngitis, tonsillitis, gingiva inflammation.
The preparation of spray containing diclofenac sodium of the present invention is at first with diclofenac sodium crude drug, propylene glycol, tween 80, Oleum menthae, glycerol mixing and stirring, add entry and sodium sulfite, stir, detect medicinal liquid content, tinning, gland seal, packing gets final product.
The local directly administration of low dosage of the present invention, affected part drug level than oral administration improves hundred times, can eliminate the pain that oral cavity and pharyngeal inflammation cause rapidly, through the animal pharmacology experiment, this poison of drug is little, and the anti-inflammatory analgesic effect is strong, successive administration 14 days, oral mucosa does not have obvious irritation, and constant product quality, and effect duration is more than 3 years.
Example of the present invention:
Example 1: prescription 1000ml
Diclofenac sodium 10g
Propylene glycol 150g
Glycerol 50g
Tween-80 25g
Oleum menthae 5g
Sodium sulfite 1g
Water is an amount of
Preparation: take by weighing diclofenac sodium, propylene glycol, glycerol, tween 80, mix homogeneously, add distilled water, sodium sulfite, stir, tinning, gland seal promptly, every jar of 25ml contains diclofenac sodium 0.25g.
Example 2: prescription 1000ml
Diclofenac sodium 20g
Propylene glycol 150g
Glycerol 50g
Tween-80 40g
Oleum menthae 5g
Sodium sulfite 2g
Water is an amount of
Preparation: but the preparation of use-case 1 method.Also can prepare as follows.Diclofenac sodium is mixed, stirs with distilled water, sodium sulfite, then in addition with propylene glycol, tween 80, peppermint, glycerol mix homogeneously, add and contain medicinal liquid, dissolving is even, tinning, gland seal, that is and, every jar of 25ml contains diclofenac sodium 0.5g.
Claims (2)
1, a kind of spray containing diclofenac sodium, it is characterized in that Main Ingredients and Appearance comprises diclofenac sodium, propylene glycol, tween 80, glycerol, Oleum menthae, sodium sulfite, distilled water, the percentage by weight of each composition is diclofenac sodium 0.5-2, propylene glycol 5-15, tween 80 0-3, glycerol 1-8, peppermint 0.1-0.8, sodium sulfite 0-0.1, distilled water 80-90.
2,, it is characterized in that clinical application is the pain that treatment oral cavity pharyngitis, tonsillitis, gingivitis cause according to the described spray containing diclofenac sodium of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95112225A CN1059797C (en) | 1995-11-22 | 1995-11-22 | Spray containing diclofenac sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95112225A CN1059797C (en) | 1995-11-22 | 1995-11-22 | Spray containing diclofenac sodium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1150541A true CN1150541A (en) | 1997-05-28 |
| CN1059797C CN1059797C (en) | 2000-12-27 |
Family
ID=5079416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95112225A Expired - Lifetime CN1059797C (en) | 1995-11-22 | 1995-11-22 | Spray containing diclofenac sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1059797C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303992C (en) * | 2002-05-10 | 2007-03-14 | 方济各安吉利克化学联合股份有限公司 | Diclofenac-based composition for the topical treatment of oropharyngeal cavity disorders |
| CN101269058B (en) * | 2007-03-20 | 2010-09-29 | 郭德 | Spraying agent containing diclofenac acid and uses thereof |
| WO2014009793A1 (en) | 2012-07-11 | 2014-01-16 | Glycores 2000 S.R.L. | Diclofenac solution for external use |
| CN112972385A (en) * | 2021-02-26 | 2021-06-18 | 广东同德药业有限公司 | Inflammation-diminishing and pain-relieving aerosol and preparation method thereof |
-
1995
- 1995-11-22 CN CN95112225A patent/CN1059797C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303992C (en) * | 2002-05-10 | 2007-03-14 | 方济各安吉利克化学联合股份有限公司 | Diclofenac-based composition for the topical treatment of oropharyngeal cavity disorders |
| CN101269058B (en) * | 2007-03-20 | 2010-09-29 | 郭德 | Spraying agent containing diclofenac acid and uses thereof |
| WO2014009793A1 (en) | 2012-07-11 | 2014-01-16 | Glycores 2000 S.R.L. | Diclofenac solution for external use |
| CN112972385A (en) * | 2021-02-26 | 2021-06-18 | 广东同德药业有限公司 | Inflammation-diminishing and pain-relieving aerosol and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1059797C (en) | 2000-12-27 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YANGPU HUAHAI PHARMACEUTICAL MATERIALS CO., LTD. Free format text: FORMER OWNER: WANG SHULI Effective date: 20030718 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20030718 Address after: 578101 Industrial Zone, Yangpu Economic Development Zone, Hainan, 5 Patentee after: Huahai Medicine Material Co., Ltd., Yangpu Address before: 250002 5-2-2, six mile south road, Ji'nan, Shandong, 7 Patentee before: Wang Shuli |
|
| C56 | Change in the name or address of the patentee |
Owner name: YANGPU WITHUB MEDICAL CO., LTD. Free format text: FORMER NAME: YANGPU HUAHAI MEDICAL MATERIAL CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: Yangpu Economic Development Zone of Hainan Province, Hong Kong Road Jinlan mall A204 room Patentee after: Yangpu Huigu Pharmaceutical Co., Ltd. Address before: No. 5, industrial zone, Yangpu Economic Development Zone, Hainan Patentee before: Huahai Medicine Material Co., Ltd., Yangpu |
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| ASS | Succession or assignment of patent right |
Owner name: JINGWEI PHARMACEUTICAL CO., LTD., SHANDONG Free format text: FORMER OWNER: YANGPU HUIGU PHARMACEUTICAL CO.,LTD. Effective date: 20100819 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 578101 ROOM A204, JINLAN SHOP, GANGBEI ROAD, YANGPU ECONOMIC DEVELOPMENT ZONE, HAINAN PROVINCE TO: 271000 MIDDLE SECTION, CHUANGYE STREET, NEW+HIGH TECHNOLOGY INDUSTRY DEVELOPMENT AREA, TAIAN CITY, SHANDONG PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20100819 Address after: 271000 middle section of pioneering street, Tai'an hi tech Industrial Development Zone, Shandong Patentee after: Jingwei Pharmaceutical Co., Ltd., Shandong Address before: Yangpu Economic Development Zone in Hainan province 578101 Hong Kong Road Jinlan mall A204 room Patentee before: Yangpu Huigu Pharmaceutical Co., Ltd. |
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| CX01 | Expiry of patent term |
Granted publication date: 20001227 |
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| EXPY | Termination of patent right or utility model | ||
| DD01 | Delivery of document by public notice |
Addressee: Mao Dexiang Document name: Notification of Expiration of Patent Right Duration |