CN115023613B - 用于检测生物分析物的传感器及其检测方法 - Google Patents

用于检测生物分析物的传感器及其检测方法

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Publication number
CN115023613B
CN115023613B CN202080094064.6A CN202080094064A CN115023613B CN 115023613 B CN115023613 B CN 115023613B CN 202080094064 A CN202080094064 A CN 202080094064A CN 115023613 B CN115023613 B CN 115023613B
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CN
China
Prior art keywords
sensor
oxygen
metal oxide
bioanalyte
binding
Prior art date
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Application number
CN202080094064.6A
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English (en)
Chinese (zh)
Other versions
CN115023613A (zh
Inventor
T·艾哈迈德
M·德林
G·佩雷勒
S·瓦利亚
M·巴斯卡兰
S·斯里拉姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Royal Melbourne Institute of Technology
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Royal Melbourne Institute of Technology
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Filing date
Publication date
Priority claimed from AU2019904865A external-priority patent/AU2019904865A0/en
Application filed by Royal Melbourne Institute of Technology filed Critical Royal Melbourne Institute of Technology
Publication of CN115023613A publication Critical patent/CN115023613A/zh
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
CN202080094064.6A 2019-12-20 2020-12-18 用于检测生物分析物的传感器及其检测方法 Active CN115023613B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019904865A AU2019904865A0 (en) 2019-12-20 Sensor for detecting a bioanalyte and a method for the detection thereof
AU2019904865 2019-12-20
PCT/AU2020/051396 WO2021119755A1 (en) 2019-12-20 2020-12-18 Sensor for detecting a bioanalyte and a method for the detection thereof

Publications (2)

Publication Number Publication Date
CN115023613A CN115023613A (zh) 2022-09-06
CN115023613B true CN115023613B (zh) 2026-04-03

Family

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CN202080094064.6A Active CN115023613B (zh) 2019-12-20 2020-12-18 用于检测生物分析物的传感器及其检测方法

Country Status (7)

Country Link
US (1) US20230045427A1 (enExample)
EP (1) EP4078182A4 (enExample)
JP (1) JP7644992B2 (enExample)
KR (1) KR20220117326A (enExample)
CN (1) CN115023613B (enExample)
AU (1) AU2020408371A1 (enExample)
WO (1) WO2021119755A1 (enExample)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105922A (zh) * 2018-01-04 2020-12-18 利腾股份有限公司 谐振气体传感器

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JP2002031598A (ja) 2000-05-11 2002-01-31 Toto Ltd センサ素子の製造方法
US6737286B2 (en) * 2001-11-30 2004-05-18 Arizona Board Of Regents Apparatus and method for fabricating arrays of atomic-scale contacts and gaps between electrodes and applications thereof
GB2420180A (en) * 2004-11-11 2006-05-17 Sensor Tech Ltd Method of electrochemical analysis of an analyte
US20100143887A1 (en) * 2008-12-05 2010-06-10 Electronics And Telecommunications Research Institute Biosensor and method for detecting biomolecules by using the biosensor
KR101191386B1 (ko) * 2008-12-19 2012-10-15 한국전자통신연구원 센서용 산화물 반도체 나노섬유 제조 방법 및 그를 이용한 가스 센서
US20100216256A1 (en) * 2009-02-17 2010-08-26 Florida State University Research Foundation Nanobelt-based sensors and detection methods
CN102449203B (zh) * 2009-06-01 2014-11-05 皇家墨尔本理工大学 电沉积的金纳米结构
JP5331952B2 (ja) 2009-06-08 2013-10-30 哲彌 逢坂 固定化方法及びセンシング方法
US9318614B2 (en) * 2012-08-02 2016-04-19 Cbrite Inc. Self-aligned metal oxide TFT with reduced number of masks and with reduced power consumption
US9064965B2 (en) * 2012-02-24 2015-06-23 Rutgers, The State University Of New Jersey Zinc oxide-based thin film transistor biosensors with high sensitivity and selectivity
GB201207585D0 (en) 2012-05-01 2012-06-13 Isis Innovation An electrode and use thereof
EP2833129B1 (en) * 2013-07-30 2019-10-09 Sensirion AG Method and apparatus for analyzing a gas by a conductance-type particulate metal-oxide gas sensor
US9702847B2 (en) 2014-12-30 2017-07-11 Avails Medical, Inc. Systems and methods for detecting a substance in bodily fluid
WO2017088016A1 (en) * 2015-11-24 2017-06-01 Rmit University A memristor device and a method of fabrication thereof
GB2548888A (en) * 2016-03-31 2017-10-04 Cambridge Display Tech Ltd Sensor, method of forming a sensor and use thereof
US9976952B2 (en) * 2016-06-03 2018-05-22 Rmit University Flexible or stretchable sensor for use in detecting a substance and/or electromagnetic radiation, and a method for detecting thereof
JP6782968B2 (ja) 2016-08-26 2020-11-11 国立大学法人東京海洋大学 電極およびバイオセンサ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105922A (zh) * 2018-01-04 2020-12-18 利腾股份有限公司 谐振气体传感器

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Rapid and Selective Biomarker Detection with Conductometric Sensors;Ganganath S. Perera 等;Small;20210218;第17卷;1-12 *

Also Published As

Publication number Publication date
EP4078182A4 (en) 2023-12-27
WO2021119755A1 (en) 2021-06-24
CN115023613A (zh) 2022-09-06
JP2023507206A (ja) 2023-02-21
CA3162465A1 (en) 2021-06-24
JP7644992B2 (ja) 2025-03-13
US20230045427A1 (en) 2023-02-09
KR20220117326A (ko) 2022-08-23
EP4078182A1 (en) 2022-10-26
AU2020408371A1 (en) 2022-07-21

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