CN114948766A - Sunscreen water dispersion slurry and preparation method thereof - Google Patents

Sunscreen water dispersion slurry and preparation method thereof Download PDF

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Publication number
CN114948766A
CN114948766A CN202210702596.4A CN202210702596A CN114948766A CN 114948766 A CN114948766 A CN 114948766A CN 202210702596 A CN202210702596 A CN 202210702596A CN 114948766 A CN114948766 A CN 114948766A
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water
sunscreen
oil
flower
natural
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Inventor
田勇
沈洁
袁菊懋
田云才
申福澈
赵晓伟
周立晓
张鑑锋
牟沛松
江忠梅
余涛
郭慧琦
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Shanghai Zhenchen Cosmetics Co Ltd
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Shanghai Zhenchen Cosmetics Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29Titanium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/413Nanosized, i.e. having sizes below 100 nm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

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  • Inorganic Chemistry (AREA)
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Abstract

The application relates to sunscreen water dispersion slurry and a preparation method thereof. The sunscreen agent water dispersion slurry comprises the following components based on the total weight of the sunscreen agent water dispersion slurry: 20-50 wt% of inorganic powder physical sun-screening agent, 5-20 wt% of natural source grease, 0.1-5 wt% of natural source emulsifier, 0.1-5 wt% of natural source preservative and 40-70 wt% of plant flower/leaf water. The sunscreen agent water dispersion slurry provided by the application contains natural source grease, on one hand, the natural source grease can be used as a dispersing agent, so that the inorganic powder physical sunscreen agent is dispersed more uniformly, and a better ultraviolet protection effect is realized; on the other hand, the natural source grease has the sun-screening synergistic function, can absorb ultraviolet light in partial wave bands, and can be used for synergistically screening sun with the inorganic powder physical sun-screening agent, so that the skin damage caused by ultraviolet radiation can be prevented or reduced; the sunscreen agent water dispersion slurry also contains plant flower/leaf water with the functions of relieving and moisturizing, and the plant flower/leaf water can relieve the skin after being dried by the sun and has the repairing function.

Description

Sunscreen water dispersion slurry and preparation method thereof
Technical Field
The application relates to the technical field of sunscreen products, in particular to sunscreen agent water dispersion slurry and a preparation method thereof.
Background
In the field of sunscreen products, sunscreens as core functional ingredients are divided into chemical sunscreens and physical sunscreens.
Chemical sunscreens, also known as organic sunscreens, are a class of organic compounds that have a good absorption of ultraviolet light. Although chemical sunscreens have a greater sun protection potential than physical sunscreens, chemical sunscreens tend to be somewhat irritating to the skin and also present a skin penetrating hazard. In common chemical sunscreen agents, such as benzophenone-3, avobenzone and the like, allergy is caused, benzophenone is selected as 2014-year Contact allergen by American Contact Dermatitis Society (American Contact Dermatitis Society), and excessive use of benzophenone is easy to cause harm to the body.
Physical sunscreens are safer, milder, and more effective than chemical sunscreens. The physical sun-screening agent is fully called as a physical ultraviolet screening agent, also called as an inorganic sun-screening agent, has better light stability, does not absorb ultraviolet rays, can reflect and scatter the ultraviolet rays, can play a physical shielding role on the skin, only stays on the surface of the skin, cannot be absorbed by the skin, has low sensitization, is comfortable in skin feel, and is more suitable for sensitive muscles and products for babies and children; in addition, the addition amount of the physical sun-screening agent can reach 25 percent, and a more effective UV all-band protection effect can be provided for the sun-screening product.
However, physical sunscreens, such as those made by adding titanium dioxide and zinc oxide powders directly to the formulation, provide greater flexibility in formulation, but generally suffer from poor dispersion and generally require higher mixing energies and more elaborate processing to be added stably to the formulation.
Disclosure of Invention
The application provides sunscreen water dispersion slurry and a preparation method thereof, and aims to solve the problems that a chemical sunscreen is easy to be allergic, and a physical sunscreen is directly applied to a formula in a powdery form to cause poor dispersibility.
In one aspect, the present embodiments provide a sunscreen water-dispersible paste comprising, based on the total weight of the sunscreen water-dispersible paste: 20-50 wt% of an inorganic powdered physical sunscreen; 5-20 wt% of natural source oil; 0.1-5 wt% of an emulsifier of natural origin; 0.1-5 wt% of a preservative of natural origin; and 40-70 wt% of plant flower/leaf water.
According to an embodiment of one aspect of the present application, the inorganic powder physical sunscreen agent comprises one or more of titanium dioxide powder, zinc oxide powder; optionally, the inorganic powder physical sunscreen has a particle size in the range of 10-500 nm.
According to an embodiment of one aspect of the present application, the inorganic powder physical sunscreen agent is an inorganic powder physical sunscreen agent coated with a coating agent selected from one or more of chitosan of natural origin, agar, agarose, cellulose, maltodextrin, modified starch, gum arabic, gelatin, soy protein, lecithin, amino acids and derivatives thereof.
According to an embodiment of one aspect of the application, the natural source of lipids includes one or more of vegetable lipids, vegetable extracts.
Optionally, the vegetable oil is selected from one or more of camellia oil, peony seed oil, olive oil, moringa seed oil, almond oil, coconut oil, shea butter, kiwi seed oil, avocado oil, grape seed oil, perilla seed oil, wheat germ oil, rice bran oil, sesame oil and safflower seed oil.
Optionally, the plant extract is selected from one or more of garcinia cambogia pericarp, sambucus nigra fruit, almond, polygonum multiflorum root, turmeric root, carnauba leaf wax, cacao pod, rosemary leaf, morinda officinalis leaf/fruit, caper fruit, silybum marianum seed, scutellaria baicalensis root, licorice root, strawberry fruit, blood orange fruit, and pteris flower extract.
Optionally, the natural source of oil and fat further comprises a natural antioxidant, and the natural antioxidant can be selected from one or more of tocopherol, tocopherol acetate and tea polyphenol.
According to an embodiment of one aspect of the present application, the natural source of emulsifier comprises a built non-ionic emulsifier and an anionic emulsifier;
the non-ionic emulsifier is selected from one or more of polyglycerol-10 myristate, polyglycerol-10 diisostearate, polyglycerol-10 dipalmitate, polyglycerol-10 stearate, polyglycerol-10 oleate, polyglycerol-10 laurate, caprylic/capric glyceride polyglycerol-10 esters, polyglycerol-6 distearate, polyglycerol-3 beeswax, polyglycerol-2 caprate, cetostearyl alcohol, cetyl alcohol, glyceryl stearate, sorbitan stearate, sucrose cocoate, sucrose stearate and polysorbate;
the anionic emulsifier is selected from one or more of sodium stearyl glutamate, sodium stearyl lactate, potassium cetyl phosphate and disodium sulfosuccinic acid monostearate.
According to an embodiment of one aspect of the application, the preservative of natural origin is selected from one or more of propylene glycol, pentylene glycol, potassium sorbate, sodium benzoate, sodium levulinate.
According to an embodiment of one aspect of the application, the plant flower/leaf water is extracted from a natural plant;
optionally, the plant flower/leaf water is selected from one or more of aloe vera leaf water, rosa damascena flower water, rose flower water, peach flower water, lotus flower water, plum flower water, lavender flower water, jasmine flower water, peony flower water, chamomile flower water, lilium albo-marginatum flower water, hamamelis virginiana flower water, aegyptian water lily flower water, and aesculus hippocastanum flower water.
In another aspect, embodiments of the present application also provide a method for preparing a sunscreen water dispersion paste, including the following steps:
providing a material in accordance with components and component amounts as defined in any one of the preceding claims;
mixing natural emulsifier, natural antiseptic, and plant flower/leaf water to obtain water phase;
adding inorganic powder physical sun-screening agent and natural source oil and fat into the water phase, and mixing to obtain sun-screening agent water dispersion slurry.
According to an embodiment of one aspect of the present application, the natural-derived emulsifier, the natural-derived preservative, and the plant flower/leaf water are mixed and emulsified by heating at a temperature of 60 to 80 ℃.
According to an embodiment of one aspect of the application, the inorganic powder physical sunscreen agent, the natural source grease and the water are mixed and homogenized to obtain the sunscreen agent water dispersion slurry.
Compared with the prior art, the application has at least the following beneficial effects:
1. the sunscreen agent water dispersion slurry provided by the application contains natural source grease, on one hand, the natural source grease can be used as a dispersing agent, so that the inorganic powder physical sunscreen agent is dispersed more uniformly, and a better ultraviolet protection effect is realized; on the other hand, the natural oil has the sun-screening synergistic function, can absorb ultraviolet light in partial wave bands, and can prevent or reduce skin damage caused by ultraviolet radiation by cooperating with the inorganic powder physical sun-screening agent.
2. The sunscreen agent water dispersion slurry provided by the application also comprises plant flower/leaf water with the effects of relieving and moisturizing, and the plant flower/leaf water can relieve the skin after sun exposure and plays a repairing role to a certain extent.
3. According to the application, the inorganic powder physical sun-screening agent is prepared into the dispersion slurry in advance, the dispersion slurry is taken as a liquid form and is easy to treat, dust is not generated when the inorganic powder physical sun-screening agent is introduced, and the difficulty of a production process is reduced; the inorganic powder physical sun-screening agent is easier to match with other components in the formula, has better dispersibility and stability in the formula system, is not easy to agglomerate and has good compatibility; compared with a mode that a physical sunscreen agent is directly applied to a formula in a powder form, the sunscreen agent water dispersion slurry can be directly applied to a water phase, a sunscreen effect is provided in the water phase, efficient sunscreen is provided, and meanwhile, lighter and thinner skin feeling is kept.
Detailed Description
In order to make the objects, technical solutions and advantageous technical effects of the present invention more clear, the present invention is further described in detail with reference to the following embodiments. It should be understood that the embodiments described in this specification are only for the purpose of explaining the present invention and are not intended to limit the present invention.
For the sake of brevity, only some numerical ranges are explicitly disclosed herein. However, any lower limit may be combined with any upper limit to form ranges not explicitly recited; and any lower limit may be combined with any other lower limit to form a range not explicitly recited, and similarly any upper limit may be combined with any other upper limit to form a range not explicitly recited. Also, although not explicitly recited, each point or individual value between endpoints of a range is encompassed within the range. Thus, each point or individual value can form a range not explicitly recited as its own lower or upper limit in combination with any other point or individual value or in combination with other lower or upper limits.
In the description herein, it is to be noted that, unless otherwise specified, "above" and "below" are inclusive, and the meaning of "a plurality" of "one or more" is two or more.
The above summary of the present invention is not intended to describe each disclosed embodiment or every implementation of the present invention. The following description more particularly exemplifies illustrative embodiments. At various points throughout this application, guidance is provided through a list of embodiments that can be used in various combinations. In various embodiments, the lists are provided as representative groups and should not be construed as exhaustive.
Sunscreen water dispersion slurry
Embodiments of the first aspect of the present application provide a sunscreen water-dispersion paste comprising, based on the total weight of the sunscreen water-dispersion paste: 20-50 wt% of an inorganic powdered physical sunscreen; 5-20 wt% of natural source oil; 0.1-5 wt% of an emulsifier of natural origin; 0.1-5 wt% of a preservative of natural origin; and 40-70 wt% of plant flower/leaf water.
According to the sunscreen agent water dispersion slurry provided by the embodiment of the application, the components play a synergistic effect by controlling the types and the contents of the components, so that the sunscreen agent water dispersion slurry is endowed with excellent sunscreen performance.
In some embodiments, the inorganic powder physical sunscreen agent comprises one or more of titanium dioxide powder, zinc oxide powder; alternatively, the particle size of the inorganic powder physical sunscreen agent is in the range of 10-500 nm.
According to the embodiment of the application, titanium dioxide powder and zinc oxide powder are used as the base materials for sunscreen, the smaller the particle size is, the better the dispersibility is, the finer the sunscreen product is when prepared, and the particle size also affects the sunscreen mechanism, for example, titanium dioxide powder, the strong anti-ultraviolet capability of titanium dioxide powder is due to its high refractive index and high optical activity, and its anti-ultraviolet capability and mechanism are related to its particle size: when the particle size is larger, the blocking of ultraviolet rays is mainly reflection and scattering, the ultraviolet rays in a medium wave region and a long wave region are effective, the sun protection mechanism is simple covering, the sun protection device belongs to general physical sun protection, and the sun protection capability is weaker; with the reduction of the particle size, light can penetrate through the particle surface of the titanium dioxide, the reflection and scattering performance of the titanium dioxide on long-wave region ultraviolet rays is not obvious, the absorption performance of the titanium dioxide on medium-wave region ultraviolet rays is obviously enhanced, and the sun protection mechanism is to absorb the ultraviolet rays and mainly absorb the medium-wave region ultraviolet rays.
In some embodiments, the inorganic powder physical sunscreen has a particle size in the range of 20-200 nm. For example, the particle size of the inorganic powder physical sunscreen agent is 20nm, 60nm, 100nm, 140nm, 180nm, 200nm, or any combination of the above values.
In some embodiments, the inorganic powder physical sunscreen agent is 20 to 50 wt%, such as 20 wt%, 25 wt%, 30 wt%, 35 wt%, 40 wt%, 45 wt%, 50 wt%, based on the total weight of the sunscreen aqueous dispersion slurry, although any combination of the above values is also possible.
In some embodiments, the inorganic powdered physical sunscreen agent is an inorganic powdered physical sunscreen agent coated with a coating agent selected from one or more of chitosan of natural origin, agar, agarose, cellulose, maltodextrin, modified starch, gum arabic, gelatin, soy protein, lecithin, amino acids, and derivatives thereof.
According to the embodiment of the present application, the inorganic powder physical sunscreen agent is surface-coated and modified by using a coating agent, so as to allow the inorganic powder physical sunscreen agent to be better dispersed in an aqueous system, and the coating agent includes, but is not limited to, a sunscreen agent loaded by a gelatinization process of modified starch, a sunscreen agent loaded by a process of preparing liposome by using lecithin, a sunscreen agent loaded by a process of curing by complex coacervation of gelatin/arabic gum or gelatin/chitosan, and the like. If the modified lecithin is modified by hydrogenated lecithin, the modified lecithin has better skin feel and skin-friendly property when being used; such as modification with gelatin or modified starch, has better light stability and water dispersibility.
In some embodiments, the naturally derived lipids include one or more of vegetable lipids, vegetable extracts.
Optionally, the vegetable oil is selected from one or more of camellia oil, peony seed oil, olive oil, moringa seed oil, almond oil, coconut oil, shea butter, kiwi seed oil, avocado oil, grape seed oil, perilla seed oil, wheat germ oil, rice bran oil, sesame oil, and safflower seed oil.
Optionally, the plant extract is selected from one or more of Garcinia cambogia pericarp, Sambucus nigra fruit, Almond, Polygonum multiflorum root, Curcuma longa root, carnauba leaf wax, Cocos cacao pod, Rosemary leaf, Morinda officinalis leaf/fruit, Poncirus trifoliata fruit, Silybum marianum seed, Scutellaria baicalensis root, Glycyrrhiza glabra root, strawberry fruit, blood orange fruit, and Clitoria ternatea flower extract.
According to the embodiment of the application, the plant oil and/or the plant extract has a sunscreen synergistic function, and can absorb ultraviolet light of partial wave bands, for example, the peony seed oil absorption wave band is 200-420nm, the camellia oil absorption wave band is 270-350nm, the olive seed oil polyphenol content is higher, and has absorptivity in the far ultraviolet region of 200-350nm, the grape seed oil high-content unsaturated fatty acid has ultraviolet absorption in the range of 217-280nm, and the silybum marianum seed, the licorice root, the strawberry fruit, the gamboge pericarp, the elderberry fruit extract and the like can resist UVA, the astragalus root, the cocoa pod, the morinda officinalis leaves/fruit, the polygonum multiflorum root, the carnauba palm leaf wax extract and the like can resist UVB. On one hand, the vegetable oil and the vegetable extract with sunscreen synergy can be used as a dispersing agent to disperse the inorganic powder physical sunscreen agent more uniformly, thereby realizing better ultraviolet protection effect; on the other hand, the compound can be used together with an inorganic powder physical sun-screening agent to play a role of synergistic sun-screening, and can prevent or reduce skin damage caused by ultraviolet radiation.
Optionally, the natural source of fat further comprises a natural antioxidant. The natural antioxidant can be one or more selected from tocopherol, tocopherol acetate, and tea polyphenols. The natural antioxidant can endow natural source oil with oxidation resistance, and prevent its denaturation and deterioration.
In some embodiments, the amount of naturally derived oils is 5-20 wt%, for example, 5 wt%, 7.5 wt%, 10 wt%, 12.5 wt%, 15 wt%, 17.5 wt%, 20 wt%, based on the total weight of the sunscreen water-dispersed slurry, although any combination of the above values is also possible.
In some embodiments, the naturally derived emulsifiers include built nonionic and anionic emulsifiers;
the non-ionic emulsifier is selected from one or more of polyglycerol-10 myristate, polyglycerol-10 diisostearate, polyglycerol-10 dipalmitate, polyglycerol-10 stearate, polyglycerol-10 oleate, polyglycerol-10 laurate, polyglycerol caprylate/caprate polyglycerol-10 esters, polyglycerol-6 distearate, polyglycerol-3 beeswax, polyglycerol-2 caprate, cetostearyl alcohol, cetyl alcohol, glyceryl stearate, sorbitan stearate, sucrose cocoate, sucrose stearate and polysorbate;
the anionic emulsifier is one or more selected from sodium stearyl glutamate, sodium stearyl lactate, potassium cetyl phosphate, and disodium sulfosuccinic acid monostearate.
According to the embodiment of the application, the emulsifier of natural source is an oil-in-water emulsifier, does not contain PEG, and is milder and safer compared with the traditional emulsification system; meanwhile, the nonionic emulsifier and the anionic emulsifier are compounded for use, so that a more excellent emulsion stabilizing effect can be provided.
In some embodiments, the emulsifier of natural origin is 0.1 to 5 wt%, for example 0.1 wt%, 0.5 wt%, 1 wt%, 1.5 wt%, 2.5 wt%, 3.5 wt%, 5 wt%, based on the total weight of the sunscreen water dispersion slurry, although any combination of the above values is also possible.
In some embodiments, the naturally derived preservative is selected from one or more of propylene glycol, pentylene glycol, sorbic acid (potassium), benzoic acid (sodium), levulinic acid (sodium).
In some embodiments, the naturally derived preservative is present in an amount of 0.1 to 5 wt%, based on the total weight of the sunscreen aqueous dispersion slurry, e.g., 0.1 wt%, 0.5 wt%, 1 wt%, 1.5 wt%, 2.5 wt%, 3.5 wt%, 5 wt%, although any combination of the above values is possible.
In some embodiments, the plant flower/leaf water is extracted from a natural plant;
optionally, the plant flower/leaf water is selected from one or more of aloe vera leaf water, rosa damascena flower water, rose flower water, peach flower water, lotus flower water, plum flower water, lavender flower water, jasmine flower water, peony flower water, chamomile flower water, lilium albo-marginatum flower water, hamamelis virginiana flower water, water lily of Egypt blue flower water, and Aesculus hippocastanum flower water.
According to the embodiment of the application, the plant flower/leaf water has the function of relieving the skin after sunburn, and is sourced from European plant aromatherapy, in the process of extracting essential oil by a distillation method, water vapor with the essential oil is collected by a guide pipe and cooled to form liquid, and then the plant flower/leaf water is separated according to the specific gravity difference of the essential oil and the water, contains trace essential oil components and water-soluble substances in all plant bodies, contains mineral nutrients (such as tannic acid and flavonoid) which are lacked by the essential oil, is small in molecules, is easier to absorb by the skin, is completely free of essence and alcohol components, is mild and is not irritant.
In some embodiments, the plant flower/leaf water is 40-70 wt%, for example, 40 wt%, 45 wt%, 50 wt%, 55 wt%, 60 wt%, 65 wt%, 70 wt%, based on the total weight of the sunscreen water dispersion slurry, although any combination of the above values is also possible.
Preparation of sunscreen water dispersion paste
Embodiments of the second aspect of the present application provide a method for preparing a sunscreen water-dispersed slurry comprising the steps of:
providing a material according to components and component contents of embodiments of a first aspect of the present application;
mixing natural emulsifier, natural antiseptic, and plant flower/leaf water to obtain water phase;
adding inorganic powder physical sun-screening agent and natural source oil and fat into the water phase, and mixing to obtain sun-screening agent water dispersion slurry.
In some embodiments, the natural source emulsifier, the natural source preservative, and the plant flower/leaf water are mixed and emulsified by heating at a temperature of 60 ℃ to 80 ℃.
According to the embodiment of the application, the emulsifier from natural sources, the preservative from natural sources and the plant flower/leaf water are mixed uniformly until the mixture is transparent and has no precipitate, and the mixture is mixed according to different substances and the mixing time is different, such as 5-10 min.
In some embodiments, an inorganic powder physical sunscreen agent, a natural source of oil, and water are mixed and homogenized to provide a sunscreen water dispersion slurry. Can be added one by one or added at a time after mixing.
According to the embodiment of the present application, a high-pressure homogenizer or a homogenizer may be used to perform a homogenization treatment to be stable and uniform. Homogenization, also known as homogenization, is a process of micronizing and homogenizing a dispersion in a suspension (or emulsion) system, and this process simultaneously serves to reduce the size of the dispersion and to improve the uniformity of distribution of the dispersion.
In some embodiments, the emulsification rate is 10000-; when a homogenizer is adopted, the rotation speed is 4000-.
According to the preparation method of the sunscreen agent water dispersion slurry, the process is simple, the inorganic powder physical sunscreen agent and other components in the formula are easy to match and use, the inorganic powder physical sunscreen agent has better dispersibility and stability in the formula system, agglomeration is not easy to occur, most of the components are natural sources, the sunscreen agent water dispersion slurry is green and safe, the sunscreen agent water dispersion slurry is particularly suitable for the natural formula system, the performance in the system is stable, the compatibility is good, and the prepared sunscreen agent water dispersion slurry has an excellent sunscreen effect.
Examples
The present disclosure is more particularly described in the following examples that are intended as illustrative only, since various modifications and changes within the scope of the present disclosure will be apparent to those skilled in the art. Unless otherwise indicated, all parts, percentages, and ratios reported in the following examples are on a weight basis, and all reagents used in the examples are commercially available or synthesized according to conventional methods and can be used directly without further treatment, and the equipment used in the examples is commercially available.
Example 1
Sunscreen water dispersion slurry
Based on the total weight of the sunscreen water dispersion paste, the sunscreen water dispersion paste comprises the following components:
inorganic powder physical sunscreen agent: 40 wt% zinc oxide powder, the zinc oxide powder being modified with hydrogenated lecithin;
natural source of fats and oils: vegetable oil and fat: 4 wt% of peony seed oil and 2 wt% of camellia oil and plant extracts: 1 wt% of silybum marianum seed extract and 1 wt% of carnauba leaf wax extract, natural antioxidants: 0.5 wt% tocopherol;
preservatives of natural origin: 0.5 wt% potassium sorbate and 0.5 wt% sodium levulinate;
emulsifiers of natural origin: 3 wt% of the non-ionic emulsifier polyglycerol-2 decanoate and 1.5 wt% of the anionic emulsifier sodium stearyl glutamate;
plant flower/leaf water: 46 wt% of Aloe vera leaf water.
Preparation of sunscreen water dispersion paste
Providing materials according to the components and the component contents;
mixing polyglycerol-2-caprate, sodium stearyl glutamate, potassium sorbate, sodium levulinate and Aloe barbadensis leaf water to obtain water phase, and heating to 70 deg.C; adding zinc oxide powder, peony seed oil, camellia oil, herba Silybi Mariani seed extract, carnauba leaf wax extract, and tocopherol into the above water phase, maintaining at 70 deg.C, and homogenizing at 8000rpm for 15 min.
Comparative example 1
Comparative example 1 differs from example 1 only in that: the zinc oxide powder was not modified.
The preparation method of the sunscreen water dispersion slurry is the same as that of example 1, and is not described herein.
Example 2
Sunscreen water dispersion slurry
Based on the total weight of the sunscreen water dispersion paste, the sunscreen water dispersion paste comprises the following components:
inorganic powder physical sunscreen agent: 45 wt% of titanium dioxide powder, wherein the titanium dioxide powder is subjected to complex coacervation, solidification and loading by gelatin/Arabic gum;
natural source of fats and oils: vegetable oil and fat: 4 wt% of peony seed oil and 2 wt% of olive seed oil, plant extracts: 1 wt% of scutellaria root extract and 1 wt% of licorice root extract, natural antioxidant: 0.5 wt% of tea polyphenols;
preservatives of natural origin: 0.5 wt% sodium benzoate and 0.5 wt% sodium levulinate;
emulsifiers of natural origin: 3.5% by weight of the non-ionic emulsifier sucrose cocoate and 1% by weight of the anionic emulsifier sodium stearoyl lactylate;
plant flower/leaf water: 41 wt% rose water.
Preparation of sunscreen water dispersion paste
Providing materials according to the components and the component contents;
mixing sucrose cocoate, sodium stearyl lactate, sodium benzoate, sodium levulinate and Hamamelis virginiana flower water uniformly to obtain a water phase; adding titanium dioxide powder, peony seed oil, olive seed oil, radix Scutellariae extract, radix Glycyrrhizae extract, and tea polyphenols into the above water phase, and homogenizing at 12000rpm for 10 min.
Comparative example 2
Comparative example 2 differs from example 2 only in that: 41 wt% of rose water is replaced by 41 wt% of deionized water.
The preparation method of the sunscreen water dispersion slurry is the same as that of example 2, and is not described herein.
Example 3
Sunscreen water dispersion slurry
Based on the total weight of the sunscreen water dispersion paste, the sunscreen water dispersion paste comprises the following components:
inorganic powder physical sunscreen agent: 20 wt% of titanium dioxide powder and 20 wt% of zinc oxide powder, wherein the titanium dioxide powder and the zinc oxide powder are gelatinized and modified by modified starch;
natural source of fats and oils: vegetable oil and fat: 4 wt% of peony seed oil and 2 wt% of moringa seed oil, plant extracts: 1 wt% strawberry fruit extract and 1 wt% cocoa pod extract, natural antioxidant: 0.5 wt% tocopheryl acetate;
preservatives of natural origin: 0.25% by weight of sodium benzoate, 0.25% by weight of potassium sorbate and 0.5% by weight of sodium levulinate;
emulsifiers of natural origin: 1.5 wt% of polyglycerol-10 myristate and 1.5 wt% of sorbitan stearate as nonionic emulsifiers, 1 wt% of potassium cetyl phosphate as anionic emulsifiers;
plant flower/leaf water: 46.5 wt% Rosa damascena flower water.
Preparation of sunscreen water dispersion paste
Providing materials according to the components and the component contents;
uniformly mixing polyglycerol-10 myristate, sorbitan stearate, potassium cetyl phosphate, potassium sorbate, sodium benzoate, sodium levulinate and Rosa damascena flower water to obtain a water phase; adding titanium dioxide powder, zinc oxide powder, peony seed oil, moringa seed oil, strawberry fruit extract, cocoa pod extract and tocopherol acetate into the water phase, and homogenizing at 15000rpm for 10min by a high-pressure homogenizer.
Comparative example 3
Comparative example 3 differs from example 3 only in that: 8 wt% of oil and fat of natural origin is replaced by 8 wt% of jojoba oil.
The preparation method of the sunscreen water dispersion slurry is the same as that of example 3, and is not described herein.
Performance testing
Examples 1-3, and comparative examples 1-3 as samples, each sample was subjected to performance tests under the same conditions, including stability test, sensory evaluation test, and skin soothing test.
1. Stability test
1.1 Heat and Cold resistance stability test
The testing steps are as follows:
1) placing each sample in an electric heating constant temperature incubator at 40-50 ℃ for 30-50 days, and observing after restoring the room temperature;
2) repeatedly changing at 0-5 deg.C within 24h for 15-30 days, and observing after recovering room temperature;
3) storing at-5 deg.C and 40 deg.C for 3 times, respectively for 24 hr, storing at-5 deg.C for 24 hr, storing at room temperature for 24 hr, storing in 40 deg.C thermostat for 24 hr, sequentially circulating for 3 times, and observing its stability;
4) the stability was observed after 1 week storage at-5 ℃.
1.2, centrifugal stability test:
each sample was placed in a centrifuge having a radius of 10cm and centrifuged at 3000r/min for 30min to observe the change in state of the sample.
The stability test results for each sample are shown in table 1.
Table 1 stability test results
Sample (I) Example 1 Comparative example 1 Examples2 Comparative example 2 Example 3 Comparative example 3
Heat resistance Without change Delamination occurred Without change Without change Without change Without change
Cold-resistant Without change Without change Without change Without change Without change Without change
Centrifugation Without change Precipitation occurs Without change Without change Without change Without change
As can be seen from Table 1, the inorganic powder physical sunscreen agent in comparative example 1 is easy to aggregate and precipitate in aqueous solution without modification, while the inorganic powder physical sunscreen agent in other examples and comparative examples has better stability, and may be loaded by complex coacervation and solidification of modified starch or gelatin/Arabic gum, so that the inorganic powder physical sunscreen agent has better light stability and water dispersibility.
2. Sensory evaluation test
Selecting 35 subjects meeting the conditions (without major diseases or skin allergy and other requirements), cleaning the arms, uniformly smearing samples on the inner side of the left arm, smearing each sample on an area of about 5cm multiplied by 5cm, and performing sensory evaluation on the smoothness and the moisture degree, wherein each full score is 10 points, taking the average value of the scores of the subjects, and the sensory evaluation test results of the samples are shown in table 2.
TABLE 2 sensory evaluation test results for the samples
Sample(s) Example 1 Comparative example 1 Example 2 Comparative example 2 Example 3 Comparative example 3
Smooth feeling 8.5 6.7 8.0 7.9 9.2 9.1
Moistening degree 9.0 8.9 7.5 7.1 7.9 9.6
From table 2, it can be seen that from the aspect of smooth feeling, the skin feeling of example 3 is the best because the inorganic powder physical sunscreen agent in example 3 is gelatinized and modified by the modified starch, probably because the skin feeling of the modified starch is relatively smooth, and secondly, the skin feeling of the inorganic powder physical sunscreen agent in example 1 is coated by the hydrogenated lecithin, so that the skin feeling is relatively good; the inorganic powder physical sunscreen agent of comparative example 1 is zinc oxide powder without any coating, and has a strong astringency, and thus is poor in smoothness.
From the viewpoint of the degree of moisturizing, the example 1, the comparative example 1 and the comparative example 3 were higher, probably because the degree of moisturizing of the camellia oil in example 1/comparative example 1 and the jojoba oil in comparative example 3 was better than that of the oils and fats in other examples.
3. Skin soothing test
Hyaluronidase (HAase) is a specific lyase of Hyaluronic Acid (HA), and inhibition of the activity of HAase can ensure that HA content and function are normal. The hyaluronidase inhibition experiment is the most typical in vitro method for evaluating the anti-allergic activity, the anti-allergic activity of a substance is evaluated by taking the hyaluronidase inhibition rate as an index, and the higher the hyaluronidase inhibition rate is, the stronger the anti-allergic activity is.
Preparation of reagents:
hyaluronidase (I): the concentration is 500U/mL, the solution is used as the solvent in the preparation, and the acetic acid buffer solution is used as the solvent;
sodium hyaluronate: 0.5mg/mL, acetic acid buffer as solvent;
acetic acid buffer solution: 4.8mL + (0.2M sodium acetate, 16.4g anhydrous sodium acetate or 27.2g sodium acetate trihydrate, dissolved in 1L distilled water) (0.2M acetic acid, 11.55mL glacial acetic acid dissolved in 1L distilled water) 45.2mL, mixed and diluted to 100mL, and prepared into an acetic acid buffer solution with the pH value of 5.6;
acetylacetone solution: 50mL of 1.0M sodium carbonate solution and 3.5mL of acetylacetone solution are mixed uniformly (for use in preparation);
P-DAB color developing agent: dissolving 0.8g of p-dimethylaminobenzaldehyde in 15mL of concentrated hydrochloric acid and 15mL of absolute ethyl alcohol, and uniformly mixing;
calcium chloride solution: 2.5 mol/L;
sodium hydroxide solution: 5 mol/L.
The experimental steps are as follows: four test tubes a-D were prepared,
a: 0.5mL of sample and 0.5mL of hyaluronidase;
b: 0.5mL of sample and 0.5mL of acetic acid buffer solution;
c: 0.5mL each of distilled water and hyaluronidase;
d: 0.5mL of each of distilled water and acetic acid buffer solution;
holding the A-D tubes at 37 deg.C for 20min, adding 0.1mL of CaCl 2 A solution;
after the temperature is kept at 37 ℃ for 20min,
adding 0.5mL of sodium hyaluronate into the A and the C, and adding 0.5mL of acetic acid buffer solution into the B and the D;
preserving the temperature at 37 ℃ for 40min, standing at room temperature for 10min, and respectively adding 0.5mL of distilled water, 0.1mL of NaOH solution and 0.5mL of acetylacetone solution into the A-D tube;
boiling in water bath for 15min, ice-cooling for 10min, standing at room temperature for 10min, adding 1mL of P-DAB into each of the four tubes, shaking completely, adding anhydrous ethanol to 8mL, standing at room temperature for 30min, and measuring light absorption value (OD value) at 530 nm.
The calculation method comprises the following steps:
hyaluronidase inhibition (%) - (C-D) - (A-B) ]/(C-D) × 100%
Wherein: OD value of a sample solution of a- (hyaluronidase + sample + sodium hyaluronate);
OD value of the B- (acetic acid buffer solution + sample + acetic acid buffer solution) sample solution;
OD value of C- (hyaluronidase + deionized water + sodium hyaluronate) sample solution;
OD value of the D- (acetic acid buffer solution + deionized water + acetic acid buffer solution) sample solution;
the hyaluronidase inhibition ratios of the samples are shown in table 3.
TABLE 3 hyaluronidase inhibition (%)
Sample (I) Example 1 Comparative example 1 Example 2 Comparative example 2 Example 3 Comparative example 3
Inhibition ratio% 41.5% 40.7% 41.7% 37.7% 39.0% 12.0%
As can be seen from table 2, in each of example 1, comparative example 1, example 2, and example 3, a plant flower/leaf water with a soothing effect is added, and a plant extract in natural oil has a certain soothing effect, so that the hyaluronidase inhibition rate is high, that is, the hyaluronidase inhibition effect is good, especially, in comparison with comparative example 2, since the plant flower/leaf water in example 2 is replaced with deionized water in comparative example 2, the hyaluronidase inhibition rate is obviously reduced, which indicates that the plant flower/leaf water has a strong soothing and repairing effect; comparative example 3 may be more affected by jojoba oil and the soothing effect is lower than the other examples.
While the present application has been described with reference to preferred embodiments, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the present application, and in particular, features shown in the various embodiments may be combined in any manner as long as there is no structural conflict. The present application is not intended to be limited to the particular embodiments disclosed herein but is to cover all embodiments that may fall within the scope of the appended claims.

Claims (10)

1. A sunscreen water dispersion paste comprising, based on the total weight of the sunscreen water dispersion paste:
20-50 wt% of an inorganic powder physical sunscreen;
5-20 wt% of natural source oil;
0.1-5 wt% of an emulsifier of natural origin;
0.1-5 wt% of a preservative of natural origin; and
40-70 wt% of plant flower/leaf water.
2. The sunscreen aqueous dispersion slurry of claim 1 wherein the inorganic powder physical sunscreen comprises one or more of titanium dioxide powder, zinc oxide powder; optionally, the inorganic powder physical sunscreen has a particle size in the range of 10-500 nm.
3. Sunscreen water dispersion paste according to claim 1 or 2 characterized in that the inorganic powdered physical sunscreen is an inorganic powdered physical sunscreen coated with a coating agent selected from one or more of chitosan of natural origin, agar, agarose, cellulose, maltodextrin, modified starch, gum arabic, gelatin, soy protein, lecithin, amino acids and their derivatives.
4. The sunscreen water dispersion paste according to claim 1, wherein the natural source oil comprises one or more of vegetable oil, vegetable extract;
optionally, the vegetable oil and fat is selected from one or more of camellia oil, peony seed oil, olive oil, moringa seed oil, almond oil, coconut oil, shea butter, kiwi seed oil, avocado oil, grape seed oil, perilla seed oil, wheat germ oil, rice bran oil, sesame oil and safflower seed oil;
optionally, the plant extract is selected from one or more of garcinia cambogia pericarp, sambucus nigra fruit, almond, polygonum multiflorum root, turmeric root, carnauba leaf wax, cacao pod, rosemary leaf, morinda officinalis leaf/fruit, caper fruit, silybum marianum seed, scutellaria baicalensis root, licorice root, strawberry fruit, blood orange fruit, and pteris flower extract;
optionally, the natural source of oil and fat further comprises a natural antioxidant, optionally, the natural antioxidant is selected from one or more of tocopherol, tocopherol acetate, and tea polyphenol.
5. The sunscreen water dispersion paste of claim 1 wherein the natural source emulsifier comprises a compounded nonionic emulsifier and an anionic emulsifier;
the non-ionic emulsifier is selected from one or more of polyglycerol-10 myristate, polyglycerol-10 diisostearate, polyglycerol-10 dipalmitate, polyglycerol-10 stearate, polyglycerol-10 oleate, polyglycerol-10 laurate, caprylic/capric glyceride polyglycerol-10 esters, polyglycerol-6 distearate, polyglycerol-3 beeswax, polyglycerol-2 caprate, cetostearyl alcohol, cetyl alcohol, glyceryl stearate, sorbitan stearate, sucrose cocoate, sucrose stearate and polysorbate;
the anionic emulsifier is selected from one or more of sodium stearyl glutamate, sodium stearyl lactate, potassium cetyl phosphate and disodium sulfosuccinic acid monostearate.
6. Sunscreen water dispersion paste according to claim 1, characterised in that the naturally derived preservative is selected from one or more of propylene glycol, pentylene glycol, sorbic acid (potassium), benzoic acid (sodium), levulinic acid (sodium).
7. The sunscreen water dispersion paste according to claim 1 wherein the plant flower/leaf water is extracted from a natural plant;
optionally, the plant flower/leaf water is selected from one or more of aloe vera leaf water, rosa damascena flower water, rose flower water, peach flower water, lotus flower water, plum flower water, lavender flower water, jasmine flower water, peony flower water, chamomile flower water, lilium albo-marginatum flower water, hamamelis virginiana flower water, aegyptian water lily flower water, and aesculus hippocastanum flower water.
8. A method for preparing a sunscreen water dispersion paste, comprising the steps of:
providing a material in accordance with the components and component contents as claimed in any one of claims 1 to 7;
mixing natural emulsifier, natural antiseptic, and plant flower/leaf water to obtain water phase;
adding inorganic powder physical sun-screening agent and natural source oil and fat into the water phase, and mixing to obtain sun-screening agent water dispersion slurry.
9. The method according to claim 8, wherein the natural-source emulsifier, the natural-source preservative, and the plant flower/leaf water are mixed and emulsified by heating at a temperature of 60 ℃ to 80 ℃.
10. The method according to claim 8, wherein the inorganic powdered physical sunscreen agent, the natural source oil and fat are mixed with the water and homogenized to obtain the sunscreen agent water dispersion slurry.
CN202210702596.4A 2022-06-21 2022-06-21 Sunscreen water dispersion slurry and preparation method thereof Pending CN114948766A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116115519A (en) * 2022-12-30 2023-05-16 水羊化妆品制造有限公司 Antibacterial composition and application thereof
EP4327799A1 (en) * 2022-08-19 2024-02-28 Patech Fine Chemicals Co., Ltd. Emulsion component and oil-in-water sunscreen product and oil-in-water sunscreen lotion including the same
CN117771147A (en) * 2023-12-20 2024-03-29 广东领康日用品有限公司 Ultraviolet-resistant and sun-resistant composition and preparation method and application thereof

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CN105708730A (en) * 2007-12-18 2016-06-29 莱雅公司 Fluid oil-in-water sunscreen emulsions containing gemini surfactants and a crosslinked copolymer of methacrylic acid and of c1-c4 alkyl acrylate

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN105708730A (en) * 2007-12-18 2016-06-29 莱雅公司 Fluid oil-in-water sunscreen emulsions containing gemini surfactants and a crosslinked copolymer of methacrylic acid and of c1-c4 alkyl acrylate

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4327799A1 (en) * 2022-08-19 2024-02-28 Patech Fine Chemicals Co., Ltd. Emulsion component and oil-in-water sunscreen product and oil-in-water sunscreen lotion including the same
CN116115519A (en) * 2022-12-30 2023-05-16 水羊化妆品制造有限公司 Antibacterial composition and application thereof
CN116115519B (en) * 2022-12-30 2024-08-23 水羊化妆品制造有限公司 Antibacterial composition and application thereof
CN117771147A (en) * 2023-12-20 2024-03-29 广东领康日用品有限公司 Ultraviolet-resistant and sun-resistant composition and preparation method and application thereof

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