CN114945589A - 多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用 - Google Patents
多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用 Download PDFInfo
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- CN114945589A CN114945589A CN202080088462.7A CN202080088462A CN114945589A CN 114945589 A CN114945589 A CN 114945589A CN 202080088462 A CN202080088462 A CN 202080088462A CN 114945589 A CN114945589 A CN 114945589A
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Abstract
本发明公开一种多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用，该多肽化合物显示出了良好的长效降血糖作用和糖尿病肾病的治疗效果；同时具有高酶解稳定性、高生物活性、无不良发应发生等效果，可以用于制备治疗摄食过量、肥胖症和超重、胆固醇升高、糖尿病及糖尿病肾病药物。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010113888 | 2020-02-24 | ||
| CN2020101138885 | 2020-02-24 | ||
| PCT/CN2020/137071 WO2021169512A1 (zh) | 2020-02-24 | 2020-12-17 | 多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114945589A true CN114945589A (zh) | 2022-08-26 |
| CN114945589B CN114945589B (zh) | 2024-05-24 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080088462.7A Active CN114945589B (zh) | 2020-02-24 | 2020-12-17 | 多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230183310A1 (zh) |
| EP (1) | EP4112637A4 (zh) |
| CN (1) | CN114945589B (zh) |
| AU (2) | AU2020431973A1 (zh) |
| WO (1) | WO2021169512A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024098718A1 (zh) * | 2022-11-07 | 2024-05-16 | 内蒙古博睿精创科技有限公司 | 一种新型长效多肽化合物、组合物及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103458920A (zh) * | 2010-12-22 | 2013-12-18 | 印第安那大学科技研究公司 | 表现出gip受体活性的胰高血糖素类似物 |
| CN104926934A (zh) * | 2014-09-23 | 2015-09-23 | 蒋先兴 | 胃泌酸调节素类似物 |
| CN106046145A (zh) * | 2016-04-22 | 2016-10-26 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化 |
| CN110305206A (zh) * | 2019-03-15 | 2019-10-08 | 中山大学 | 一类双靶点多肽化合物及其在制备治疗糖尿病和以其为特征的病症的药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6184404B2 (ja) * | 2011-06-22 | 2017-08-23 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | グルカゴン／ｇｌｐ−１レセプターコアゴニスト |
| JP6311708B2 (ja) * | 2012-06-21 | 2018-04-18 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | Ｇｉｐ受容体活性を示すグルカゴンアナローグ |
| CA2877127A1 (en) * | 2012-06-21 | 2013-12-27 | Indiana University Research And Technology Corporation | Analogs of glucagon exhibiting gip receptor activity |
-
2020
- 2020-12-17 EP EP20922203.3A patent/EP4112637A4/en active Pending
- 2020-12-17 WO PCT/CN2020/137071 patent/WO2021169512A1/zh unknown
- 2020-12-17 AU AU2020431973A patent/AU2020431973A1/en not_active Abandoned
- 2020-12-17 US US17/801,465 patent/US20230183310A1/en active Pending
- 2020-12-17 CN CN202080088462.7A patent/CN114945589B/zh active Active
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103458920A (zh) * | 2010-12-22 | 2013-12-18 | 印第安那大学科技研究公司 | 表现出gip受体活性的胰高血糖素类似物 |
| CN104926934A (zh) * | 2014-09-23 | 2015-09-23 | 蒋先兴 | 胃泌酸调节素类似物 |
| CN106046145A (zh) * | 2016-04-22 | 2016-10-26 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化 |
| CN110305206A (zh) * | 2019-03-15 | 2019-10-08 | 中山大学 | 一类双靶点多肽化合物及其在制备治疗糖尿病和以其为特征的病症的药物中的应用 |
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| US20230183310A1 (en) | 2023-06-15 |
| AU2024203093A1 (en) | 2024-05-30 |
| CN114945589B (zh) | 2024-05-24 |
| WO2021169512A1 (zh) | 2021-09-02 |
| AU2020431973A1 (en) | 2022-09-22 |
| EP4112637A1 (en) | 2023-01-04 |
| EP4112637A4 (en) | 2024-04-03 |
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