CN114942337A - Film reading instrument and film reading control method thereof - Google Patents

Film reading instrument and film reading control method thereof Download PDF

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Publication number
CN114942337A
CN114942337A CN202210607767.5A CN202210607767A CN114942337A CN 114942337 A CN114942337 A CN 114942337A CN 202210607767 A CN202210607767 A CN 202210607767A CN 114942337 A CN114942337 A CN 114942337A
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China
Prior art keywords
slide
frame
microscopic examination
slide frame
conveying
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CN202210607767.5A
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Chinese (zh)
Inventor
林冲
卢江涛
杨旭泉
徐家宏
闫红力
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Shenzhen Reetoo Biotechnology Co Ltd
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Shenzhen Reetoo Biotechnology Co Ltd
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Priority to CN202210607767.5A priority Critical patent/CN114942337A/en
Publication of CN114942337A publication Critical patent/CN114942337A/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
    • G01V9/00—Prospecting or detecting by methods not provided for in groups G01V1/00 - G01V8/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1051—General features of the devices using the transfer device for another function for transporting containers, e.g. retained by friction

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Robotics (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geophysics (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

The application relates to a film reading instrument and a film reading control method thereof, wherein the film reading instrument comprises: a feeding mechanism for feeding a slide frame loaded with a slide; a slide frame inverting mechanism configured to receive the slide frame fed from the feeding mechanism and invert the slide frame; the glass slide conveying mechanism is used for conveying the glass slides in the turned glass slide frames to a microscopic examination position for microscopic examination; the microscopic examination mechanism is arranged at the microscopic examination position and is used for microscopic examination of the slide; and the controller is configured to control the slide conveying mechanism to convey the slide in the slide frame to the microscopic examination position for microscopic examination after the slide frame overturning mechanism overturns the slide frame. The slide reading instrument in the technical scheme integrally overturns the slide frame through the slide frame overturning mechanism, the slide conveying mechanism conveys a slide in the overturned slide frame, the slide does not need to be overturned piece by piece in the slide conveying process, the conveying speed can be increased, the slide reading efficiency is improved, and meanwhile, the slide is prevented from being damaged or polluted when being overturned piece by piece.

Description

Film reading instrument and film reading control method thereof
Technical Field
The application belongs to the technical field of slide examination equipment, and relates to a slide reading instrument and a slide reading control method of the slide reading instrument.
Background
The slide reading instrument is a device for carrying out automatic microscopic examination on slide to be detected after slide preparation, samples on the slide are photographed through a microscope, detection results are obtained through system analysis and judgment, diagnosis of diseases is assisted, and the samples can be human excrement, secretion, cast-off cells or human tissues, animal tissues, even plant cells and the like. The slide needs to be kept horizontal during the microscopic examination process, and the conventional slide reading device usually turns the slide one by one during the slide conveying process to perform the microscopic examination.
Disclosure of Invention
The technical scheme of this application provides a read piece appearance, includes:
a feeding mechanism for feeding a slide frame loaded with a slide;
a slide frame inverting mechanism configured to receive the slide frame fed from the feeding mechanism and invert the slide frame;
the glass slide conveying mechanism is used for conveying the glass slides in the turned glass slide frames to a microscopic examination position for microscopic examination;
the microscopic examination mechanism is arranged at the microscopic examination position and is used for microscopic examination of the slide;
a controller configured to control the slide transport mechanism to transport the slide in the slide frame to the microscopy site for microscopy after the slide-frame flipping mechanism flips the slide frame.
The slide reading instrument in the technical scheme integrally overturns the fed slide frame through the slide frame overturning mechanism, the slide conveying mechanism directly conveys the slide in the overturned slide frame, the slide conveying mechanism does not need to overturn one by one in the slide conveying process, the conveying beam degree can be improved, the slide reading efficiency is improved, and meanwhile, the damage or pollution to the slide caused by the slide overturning one by one is avoided.
In one embodiment of this technical solution, the slide reader further includes a driving mechanism for driving the slide frame turning mechanism to move up and down, so that the slide conveying mechanism can switch and convey the slide in the slide frame.
In one embodiment of this technical solution, the slide reader further comprises a slide detection mechanism, and the slide detection mechanism is used for detecting the presence or absence of a slide on each slide position in the slide frame on the slide frame turnover mechanism; alternatively, the first and second electrodes may be,
the controller is configured to control the slide sensing mechanism to move up and down to sense the presence or absence of a slide on each slide location in a slide frame on the slide frame flipping mechanism via the slide sensing mechanism.
In one embodiment of this embodiment, the controller is configured to control the driving mechanism to drive the slide frame inverting mechanism to move up and down to detect the presence or absence of a slide on each slide position in a slide frame on the slide frame inverting mechanism via the slide detecting mechanism.
In one embodiment of this technical solution, the slide frame turning mechanism includes an accommodating structure for accommodating a slide frame and a rotating assembly for driving the accommodating structure to rotate so as to turn the slide frame.
In one embodiment of this technical solution, the slide reader further includes a scanning module;
the slide conveying mechanism is further used for conveying the slide in the turned slide frame to a scanning position, and the scanning module is arranged at the scanning position and used for scanning a label area of the slide to acquire label identification information of the slide.
In one embodiment of this embodiment, the slide frame inverting mechanism is configured to rotate the slide frame from a state in which the opening faces upward to a state in which the opening faces sideways.
In one embodiment of this embodiment, the slide frame flipping mechanism is configured to rotate the slide frame 90 degrees from an open-up position.
In one embodiment of this embodiment, the slide conveying mechanism is further configured to convey the slide subjected to the microscopic examination from the microscopic examination position to the slide frame of the slide frame overturning mechanism; alternatively, the first and second electrodes may be,
the slide conveying mechanism is also used for conveying the slide subjected to the microscopic examination treatment from the microscopic examination position to the recovery area.
In one embodiment of this embodiment, the slide transport mechanism includes a slide removing assembly and a drive assembly;
the slide moving assembly is used for moving a slide from the turned slide frame, and the driving assembly is used for driving the slide moving assembly to horizontally move and/or lift so as to enable the slide conveying mechanism to switch and convey the slide in the slide frame and/or enable the slide moving assembly to convey the slide to the microscopic examination position.
In one embodiment of this embodiment, the slide moving assembly includes a gripping structure and a driving structure; the driving structure is used for driving the clamping structure to open and close so as to clamp or loosen the slide.
In an embodiment of this technical solution, the slide moving assembly is further configured to clamp a slide and convey the slide to the microscopy site, and the microscopy mechanism is configured to perform microscopy on the slide clamped on the slide moving assembly located at the microscopy site.
In one embodiment of this technical solution, the slide moving assembly includes a push rod, and the driving assembly is configured to drive the push rod to push out the slide in the turned slide frame.
Another technical solution of the present application is to provide a slide reading control method of a slide reading apparatus, the slide reading apparatus includes a controller, a slide frame turning mechanism, a slide conveying mechanism, and a microscopy mechanism, the controller is configured to control the slide frame turning mechanism, the slide conveying mechanism, and the microscopy mechanism to implement the following steps:
the slide frame overturning mechanism overturns the received slide frame;
the glass slide conveying mechanism conveys the glass slides in the overturned glass slide frame to a microscopic examination position;
the microscopic examination mechanism is used for microscopic examination of the glass slide positioned at the microscopic examination position.
According to the slide reading control method, the slide frame is integrally turned through the slide frame turning mechanism, so that the slide conveying mechanism can directly convey the turned slide in the slide frame, the slide conveying mechanism does not turn the slide one by one in the slide conveying process any longer, the slide reading efficiency can be improved, and meanwhile, the slide is prevented from being damaged or polluted when turned one by one.
In an embodiment of this embodiment, after the microscopic examination of the slide located at the microscopic examination position, the microscopic examination mechanism further includes the following steps:
the glass slide frame turnover mechanism lifts the turned glass slide frame;
and the slide conveying mechanism conveys the other slide in the overturned slide frame to a microscopic examination position.
In an embodiment of this technical solution, the slide reader further includes a scanning module block, and the controller is further configured to control the scanning module to implement the following steps:
the glass slide conveying mechanism conveys the glass slides in the overturned glass slide frame to a scanning position;
the scanning module scans a label area of the slide to obtain label identification information of the slide.
In one embodiment of this embodiment, the slide reader further comprises a slide detection mechanism, and the controller is further configured to control the slide detection mechanism and the slide frame inverting mechanism to implement the following steps:
the glass slide frame turnover mechanism lifts the turned glass slide frame to a detection position;
the slide sensing mechanism senses the slide frame at the sensing position to obtain the presence and/or position of the slide in the slide frame.
In an embodiment of this embodiment, after the microscopic examination of the slide located at the microscopic examination position, the microscopic examination mechanism further includes the following steps:
the slide conveying mechanism conveys the slide subjected to microscopic examination treatment to a slide frame of the slide frame turnover mechanism; alternatively, the first and second electrodes may be,
and the slide conveying mechanism conveys the slide subjected to microscopic examination to a recovery area.
In an embodiment of this embodiment, the reading apparatus further includes a feeding mechanism, and the controller is further configured to control the feeding mechanism to implement the following steps:
the feeding mechanism conveys the slide frame loaded with the slide to the slide frame overturning mechanism.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
Drawings
The foregoing and other objects, features and advantages of the application will be apparent from the following more particular descriptions of exemplary embodiments of the application, as illustrated in the accompanying drawings wherein like reference numbers generally represent like parts throughout the exemplary embodiments of the application.
Fig. 1 is a schematic structural diagram of a slide reader shown in an embodiment of the present application.
Fig. 2 is a schematic structural diagram of the interior of the slide reader shown in an embodiment of the present application.
Fig. 3 is a schematic structural view of a positional relationship between the microscopy mechanism and the slide transfer mechanism shown in an embodiment of the present application.
FIG. 4 is a schematic structural view showing the positional relationship of the feeding mechanism, slide frame inverting mechanism, and drive mechanism shown in an embodiment of the present application.
FIG. 5 is a schematic view of the slide frame flipping mechanism shown in an embodiment of the present application in positional relationship with the slide transport mechanism.
FIG. 6 is a schematic structural view of the positional relationship of the slide frame inverting mechanism and the drive mechanism shown in an embodiment of the present application.
Fig. 7 is a schematic structural view of a slide conveying mechanism shown in an embodiment of the present application.
Fig. 8 is a schematic top view of the feeding mechanism shown in an embodiment of the present application.
Fig. 9 is a schematic structural view of a slide frame shown in an embodiment of the present application.
Fig. 10 is a flowchart of a radiographing control method shown in an embodiment of the present application.
Fig. 11 is a flowchart of switching slide microscopy of the slide reading control method shown in an embodiment of the present application.
Fig. 12 is a flowchart of slide scanning of the slide reading control method shown in an embodiment of the present application.
Fig. 13 is a flowchart of slide detection within a slide frame of the slide reading control method shown in an embodiment of the present application.
Fig. 14 is a flowchart of recovery after microscopic examination of a slide in the slide reading control method shown in an embodiment of the present application.
Description of reference numerals:
100-reading device;
110-a feed mechanism; 111-a transfer track; 1111-feeding position; 1112-a feed position; 1113-discharge position; 112-a first transport assembly; 113-a feed module; 114-a discharge module;
120-slide frame turnover mechanism; 120 a-a containment structure; 120 b-a rotating assembly; 121-a connector; 122-a first clamp; 123-a second clamp; 124-a containing groove; 125-a mounting member; 126-a first motor; 127-a rotating member; 128-a transmission;
130-slide transport mechanism; 131-a slide removal assembly; 132-a drive assembly; 133-a gripping structure; 134 a drive structure;
140-microscopic examination mechanism;
150-a drive mechanism; 151-a mount; 152-a guide rail assembly; 153-a lead screw assembly; 154-a second electric machine;
160-slide detection mechanism; 161-a stent; 162-a detection component;
200 slide frames; 201 is opened; 202 fool-proof groove; 203-grooves; 210-slide; 211-tag area.
Detailed Description
Technical solutions in some embodiments of the present application will be clearly and completely described below with reference to the drawings in some embodiments of the present application, and it is obvious that the described embodiments are some, but not all, embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that all the directional indications (such as up, down, left, right, front, and rear … …) in the embodiment of the present application are only used to explain the relative positional relationship between the components, the motion situation, and the like in a specific posture, and if the specific posture is changed, the directional indication is changed accordingly. It will also be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or be indirectly connected to the other element through intervening elements.
In addition, the descriptions referred to as "first", "second", etc. in this application are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicit ly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between the embodiments may be combined with each other, but must be based on the realization of the technical solutions by a person skilled in the art, and when the technical solutions are contradictory to each other or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope claimed in the present application.
It is also to be understood that the terminology used in the description of the present application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in the specification of the present application and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be further understood that the term "and/or" as used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.
The technical solutions of the embodiments of the present application are described in detail below with reference to the accompanying drawings.
Referring to fig. 9, for convenience of explanation, in the present embodiment, there is exemplarily provided a slide frame 200 loaded with slides 210, the slide frame 200 being provided with an opening 201, the slides 210 being inserted into the slide frame 200 from the opening 201, the slide frame 200 having a plurality of slide sites for loading the slides 210, the slide sites being equidistantly spaced such that a gap is present between adjacent slides 210 loaded onto the slide sites, and one slide 210 being vertically insertable into each slide site. Unless otherwise specified, all the slides 210 in the present application are pre-processed and loaded with samples and mounted, and the sample-loaded sides of all the slides 210 in the slide frame 200 face the same direction.
The slide frame 200 is of a depth such that the sample area of the slide 210 is inserted into the slide frame 200 and the label area 211 of the slide 210 is exposed outside of the opening 201, the label area 211 being used for gripping the slide 210 by equipment or manually taking the slide 210. A fool-proof groove 202 is provided at the bottom of the slide frame 200. Grooves 203 are formed in two outer side walls of the slide frame 200 along the length direction of the slide frame, the grooves 203 extend along the length direction of the slide frame 200, and the grooves 203 are used for being positioned when the device grabs the slide frame 200.
Referring to fig. 1 to 5, the present embodiment provides a slide reader 100, including a feeding mechanism 110, a slide frame inverting mechanism 120, a slide conveying mechanism 130, a microscopy mechanism 140, and a controller, the feeding mechanism 110 being used for feeding a slide frame 200 loaded with a slide; the slide frame inverting mechanism 120 is configured to receive the slide frame 200 fed from the feeding mechanism 110 and invert the slide frame 200; the slide conveying mechanism 130 is used for conveying the overturned slide in the slide frame 200 to a microscopy position for microscopy; the microscopic examination mechanism 140 is arranged at the microscopic examination position and is used for microscopic examination of the slide; the controller is configured to control the slide transport mechanism 130 to transport slides in the slide frame 200 to the microscopy site for microscopy after the slide frame flipping mechanism 120 flips the slide frame 200.
It can be understood that, when the slide is detected by the microscopic detection mechanism 140, the slide needs to be kept in a horizontal state, and when the slide is fed, the slide in the slide frame 200 is vertically placed, and the vertically placed slide is taken from the slide frame 200 one by one and then turned over, and a large number of same actions need to be repeated for the taking and conveying of the slide, so that the slide reading structure is complex, the microscopic detection process is slow, and the slide reading efficiency cannot be improved.
The slide frame 200 loaded with the slide is fed from the feeding mechanism 110, when the feeding mechanism 110 feeds the slide frame 200, the slide frame 200 is conveyed with the opening facing upward, the slide frame turnover mechanism 120 turns over the slide frame 200 to enable the opening to face the side edge after receiving the slide frame 200, and the slide conveying mechanism 130 conveys the turned slide frame 200 to the microscopic examination position one by one for microscopic examination.
So, carry out whole upset through slide frame tilting mechanism 120 to slide frame 200, slide conveying mechanism 130 directly carries the slide in the slide frame 200 after the upset, and slide conveying mechanism 130 no longer carries out the slide upset one by one in the slide conveying process, can improve the efficiency of reading the piece, has also avoided the slide to produce the damage or the pollution to the slide when overturning one by one simultaneously.
Referring to fig. 5 and 6, in the present embodiment, the slide frame inverting mechanism 120 includes a receiving structure 120a for receiving the slide frame 200 and a rotating assembly 120b for driving the receiving structure 120a to rotate to invert the slide frame 200.
The accommodating structure 120a includes a connecting member 121, a first clamping member 122 and a second clamping member 123, the first clamping member 122 and the second clamping member 123 are connected to the connecting member 121 and are disposed at an interval, an accommodating groove 124 capable of accommodating the slide frame 200 is formed between the first clamping member 122 and the second clamping member 123, and when the slide frame 200 is located in the accommodating groove 124 of the accommodating structure 120a, the first clamping member 122 and the second clamping member 123 are respectively disposed in the grooves of the slide frame 200.
Thus, the accommodating groove 124 through the accommodating structure 120a can accommodate the slide frame 200, and the slide frame 200 is prevented from moving up and down and sliding down through the clamping piece and the position of the positioning slide frame 200 with good adaptation of the groove on the slide frame 200.
The rotating assembly 120b includes a mounting member 125, a first motor 126, a rotating member 127 and a transmission member 128, the first motor 126 is connected to the mounting member 125, the rotating member 127 is rotatably connected to the mounting member 125, the first motor 126 drives the rotating member 127 to rotate through the transmission member 128, the first clamping member 122 of the accommodating structure 120a is connected to the rotating member 127, the transmission member 128 is a conveyor belt, the rotating member 127 is provided with a driven wheel, an output shaft of the first motor 126 is provided with a driving wheel, and the transmission member 128 is connected between the driving wheel and the driven wheel to realize power transmission.
Thus, the rotation of the rotating member 127 drives the accommodating structure 120a to rotate, so that the slide frame 200 on the accommodating structure 120a can be turned over.
In the present embodiment, the slide frame inverting mechanism 120 is configured to rotate the slide frame 200 from the state of opening upward to the state of opening to the side.
Thus, the slide conveying mechanism 130 can be disposed at the side of the slide frame turning mechanism 120, and the slide in the turned-over slide frame 200 can be conveyed to the microscopic examination position by the side of the slide frame turning mechanism 120 for microscopic examination.
Preferably, the slide frame flipping mechanism is configured to rotate the slide frame 200 90 degrees from the open-up position.
Thus, after the glass frame 200 with the upward opening rotates 90 degrees, the opening faces the horizontal direction, and the slide in the glass frame 200 is placed in the horizontal state, so that the slide conveying mechanism 130 can directly convey the slide in the horizontal state to the specular microscope for specular observation.
Referring to fig. 6, in the present embodiment, the slide reader 100 further includes a driving mechanism 150, the slide frame turning mechanism 120 is connected to the driving mechanism 150, and the driving mechanism 150 is used for driving the slide frame turning mechanism 120 to move up and down, so that the slide conveying mechanism 130 can switch and convey the slides in the slide frames 200.
So, make slide frame tilting mechanism 120 go up and down through actuating mechanism 150 for slide conveying mechanism 130 need not go up and down can switch the slide in carrying slide frame 200 piece by piece, and it is safer in direct lift slide to drive slide lift switching through lift slide frame 200, prevents that slide lift in-process from producing the phenomenon of collision, slide rupture, can improve the efficiency of going to the piece simultaneously.
Specifically, the driving mechanism 150 includes a fixing frame 151, a guide rail assembly 152, a screw rod assembly 153 and a second motor 154, the guide rail assembly 152 is vertically connected to the fixing frame 151, the second motor 154 is installed on the fixing frame 151, the installation part 125 of the rotating assembly 120b is connected to the sliding table of the guide rail assembly 152, the rotating assembly 120b can move along the guide rail assembly 152 relative to the fixing frame 151, a screw rod of the screw rod assembly 153 is connected to an output shaft of the first motor 126, a nut of the screw rod assembly 153 is connected to the installation part 125 of the rotating assembly 120b, and the second motor 154 drives the rotating assembly 120b to move up and down through the screw rod assembly 153.
Thus, the slide frame 200 is lifted and lowered by the cooperation of the guide rail assembly 152 and the lead screw assembly 153, and the lifting and lowering movement of the slide conveying mechanism 130 is more stable.
Referring to fig. 6, in this embodiment, the slide reader 100 further includes a slide detection mechanism 160, the slide detection mechanism 160 being configured to detect the presence or absence of a slide at each slide location in the slide frames 200 positioned on the slide frame flipping mechanism 120.
Wherein the controller is configured to control the drive mechanism 150 to drive the slide frame flipping mechanism 120 up and down to detect the presence or absence of a slide on each slide location in the slide frame 200 positioned on the slide frame flipping mechanism 120 via the slide detection mechanism 160.
Thus, the slide detecting mechanism 160 can detect whether a slide exists at each slide position in the slide frame 200, and the obtained detection result is used as the basis for the subsequent slide conveying of the slide frame 200, for example, a certain slide position of the slide frame 200 is empty in the detection result, and the slide position can be directly skipped during the slide conveying, so as to prevent the device from idle running and improve the slide reading efficiency.
It will be appreciated that the slide sensing mechanism 160 is not limited to the above-described manner, for example, in other embodiments, the slide sensing mechanism 160 can be raised and lowered, and the controller can be configured to control the lift and lowering of the slide sensing mechanism 160 to detect the presence or absence of a slide on each of the slide locations in the slide frame on the slide frame flipping mechanism via the slide sensing mechanism 160.
Slide detection mechanism 160 locates slide frame tilting mechanism 120 side, slide frame tilting mechanism 120 overturns behind slide frame 200, control slide frame 200 from last to down or from the supreme motion through slide detection mechanism 160 of following, or from last to down or from the supreme slide detection mechanism 160 that moves down, detect whether there is a slide in each slide placement position on slide frame 200, the condition is placed to the slide in every slide position on the memory record detection slide frame 200, after the detection, from supreme or from last to down according to the slide placement condition in every slide position and carry out the slide and pick up, slide frame 200 has 10 slide placement positions from 1-10 for example, if detect the slide placement position of 1-7 and placed the slide, all the other slides have not been placed, then when carrying out control and picking up, only control slide conveying mechanism 130 picks up the slide of the slide placement position on 1-7.
Optionally, the slide detecting mechanism 160 includes a frame 161 and a detecting assembly 162 mounted on the frame 161, the detecting assembly 162 drives the slide frame 200 to move up and down by the driving mechanism 150, and the detecting assembly 162 is disposed on a path along which the slide frame 200 moves up and down. In this manner, the detection assembly 162 obtains detection results as the slide frame 200 passes through its detection range.
Referring to fig. 4 and 8, in the present embodiment, the feeding mechanism 110 is used to feed the slide frame 200 loaded with slides, illustratively, the feeding mechanism 110 includes a transfer module, an in-feed module 113, and an out-feed module 114, the transfer module includes a transfer rail 111 and a first transport assembly 112112, the transfer rail 111 is used to transport the slide frame 200 loaded with slides, the transfer rail 111 is provided with an in-feed position 1111, an in-feed position 1112, and an out-feed position 1113, the first transport assembly is used to transport the slide frame 200 along the transfer rail 111; the infeed module 113 is used to deliver the slide frame 200 to the infeed location 1112 of the transfer track 111; the outfeed module 114 is configured to receive outfeeds of the slide frames 200 from the outfeed position 1113 of the transfer rail 111.
The slide frame turnover mechanism 120 is disposed at the loading position 1111 of the transfer track 111 of the feeding mechanism 110, and the slide frame turnover mechanism loads the slide frame 200 in a process that the rotating assembly 120b rotates to make the opening of the containing groove 124 of the containing structure 120a face the transfer track 111, the driving mechanism 150 descends to make the containing structure 120a reach a designated height, the first conveying assembly 112 receives the slide frame 200 from the feeding module 113 at the feeding position 1112, conveys the slide frame to the loading position 1111 along the transfer track 111, pushes the slide frame 200 into the containing groove 124 of the containing structure 120a, and the driving mechanism 150 ascends to make the slide frame 200 leave the first conveying assembly 112.
In addition, the feeding mechanism 110 can also receive the slide frame 200 after the microscopic examination is completed, the slide frame flipping mechanism flips the examined slide frame 200 to make the opening of the slide frame 200 face upward, and the slide frame is lowered to the first conveying assembly 112 at the loading position 1111, and the first conveying assembly 112 conveys the slide frame 200 to the discharging position 1113, and finally enters the discharging module 114.
Referring to fig. 5 and 7, in this embodiment, the slide transport mechanism 130 is also used to transport a mirrored slide from the mirroring position into the slide frame 200 of the slide frame flipping mechanism 120; alternatively, the slide transport mechanism 130 is also used to transport the microscopically processed slide from the microscopy site to the recovery area.
It is understood that after the slide has been microscopically examined, there are two processing modes, namely, the original transportation mode is returned to the slide frame 200, and the second transportation mode is conveyed to the recovery area, and regardless of the slide processing mode, the slide frame 200 after the slide has been microscopically examined is returned to the feeding mechanism 110 to the transfer rail 111, transported to the discharging position 1113 by the first transportation, and finally enters the discharging module 114.
Thus, the slide after microscopic examination can be recovered, and meanwhile, the slide frame 200 can also be automatically discharged.
Referring to fig. 5 and 7, in the present embodiment, the slide transport mechanism 130 includes a slide removal assembly 131 and a drive assembly 132; the slide removal assembly 131 is configured to remove a slide from the inverted slide frame 200, and the drive assembly 132 is configured to drive the slide removal assembly 131 to move horizontally and/or to raise and lower so that the slide removal assembly 131 delivers the slide to the microscopy site.
Specifically, the slide transfer assembly 131 includes a gripping structure 133 and a driving structure 134; the driving mechanism 134 is used to drive the gripping mechanism 133 to open and close to grip or release the slide.
Preferably, the gripping structure 133 is a gripping jaw, the gripping structure 133 is connected to the driving assembly 132, the driving structure 134 is a cylinder or a motor, and the driving structure 134 is connected to the gripping structure.
Understandably, drive assembly 132 includes the cross straight line slip table module that the level set up for drive assembly 132 can drive slide on the level and move subassembly 131 and carry out X axle and Y axle direction motion, for example, when drive assembly 132 drives the slide and moves subassembly 131 along the motion of Y axle direction, can make slide move subassembly 131 take out the slide from the slide frame 200 after the upset, when drive assembly 132 drives slide and moves subassembly 131 along the motion of X axle direction, can make slide move subassembly 131 remove the back slide that will take out and move the mirror examination position.
In some other embodiments, the drive assembly 132 can further include a linear slide module disposed vertically such that the drive assembly 132 can drive the slide removal assembly 131 in an up-and-down motion to enable the slide transport mechanism 130 to switch the slides in the transport slide frame 200.
In this way, the slide is gripped by the slide moving assembly 131, and the driving assembly 132 drives the slide moving assembly 131 to move, so that the slide conveying is realized.
In this embodiment, the slide moving assembly 131 is further configured to clamp a slide and convey the slide to the microscopy site, and the microscopy mechanism 140 is configured to perform microscopy on the slide clamped on the slide moving assembly 131 located at the microscopy site.
Understandably, the slide moving assembly 131 can be used as a microscopic examination platform for microscopic examination of the slide, without providing the microscopic examination platform, the slide is directly clamped on the slide moving assembly 131 for microscopic examination, the slide moving assembly 131 can keep the slide processing horizontal state, and the slide moving assembly 131 is also convenient for recovering and conveying the slide after the microscopic examination is completed.
Thus, the slide microscopic examination without the microscopic examination platform is realized through the slide moving assembly 131, the structure is simplified, the conveying of the slide between the slide conveying mechanism 130 and the microscopic examination platform is omitted, and the speed of the slide conveying and the microscopic examination is accelerated.
In certain other embodiments, the slide transport mechanism 130 can be replaced by the slide transport mechanism 130 including a slide removing assembly 131 and a drive assembly 132, the slide removing assembly 131 including a push rod, the push rod not shown, the drive assembly 132 being configured to drive the push rod to push out the slide in the inverted slide frame 200.
It can be understood that the opening of the slide frame 200 faces the side after the slide frame is turned over, so that the slide is in the state of being laid flat to process the slide frame 200. assuming that a through hole is opened at the bottom of each slide position of the slide frame 200, the slide moving assembly 131 is arranged at the side of the slide frame turning mechanism 120, the bottom of the slide frame 200 after the slide frame is turned over faces the slide moving assembly 131, and the opening of the slide frame 200 faces the microscopic examination platform.
In this manner, the slide is pushed out of the slide frame 200 by the push rod from the bottom of the slide frame 200, so that the slide is pushed to the microscopy position on the microscopy platform, and the microscopy mechanism 140 performs microscopy on the slide located at the microscopy position.
Referring to fig. 3, in the present embodiment, the microscopy mechanism 140 is disposed at the microscopy position and is configured to perform microscopy on a slide, the microscopy mechanism 140 includes an optical microscope and a camera, a sample image generated by the camera after a sample on the slide is amplified by the optical microscope is generated, and the sample image is analyzed to obtain a microscopy result of the slide.
In this embodiment, the film reader 100 further includes a scanning module; the slide conveying mechanism 130 is further configured to convey the slide in the turned-over slide frame 200 to a scanning position, and the scanning module is disposed at the scanning position and configured to scan a label area of the slide to obtain label identification information of the slide. It will be appreciated that after the slide transport mechanism 130 removes the slides from the slide frame 200, the slides are first transported to the scanning position before being transported to the microscopy site, and the scanning module is positioned in the slide transport path of the slide transport mechanism 130.
Optionally, the tag area includes a two-dimensional code, the description module includes a scanning camera, and the scanning camera can set the two-dimensional code of the tag area.
In this way, the scanning module can identify the label identification information of the slide, and sample information corresponding to the slide is obtained, so that the microscopic examination result and the sample information are associated.
Referring to fig. 10, a second embodiment of the present application provides a slide reading control method of the slide reader 100, the slide reader 100 comprises a controller, a slide frame overturning mechanism 120, a slide conveying mechanism 130 and a microscopy mechanism 140, the controller is configured to control the slide frame overturning mechanism 120, the slide conveying mechanism 130 and the microscopy mechanism 140 to realize the following steps:
s101, the slide frame overturning mechanism 120 overturns the received slide frame 200;
s102, the slide conveying mechanism 130 conveys the overturned slide in the slide frame 200 to a microscopic examination position;
s103, the microscopic examination mechanism 140 performs microscopic examination on the slide located at the microscopic examination position.
So, carry out the step of whole upset through slide frame tilting mechanism 120 to slide frame 200 for slide among the slide frame 200 after the upset can directly be carried to slide conveying mechanism 130, slide conveying mechanism 130 no longer carries out the slide upset one by one in the slide transportation process, can improve the efficiency of reading the piece, has also avoided the slide to produce the damage or the pollution to the slide when overturning one by one simultaneously.
Referring to fig. 11, optionally, after the step of performing microscopy on the slide at the microscopy site by the microscopy mechanism 140 in S103, the following steps S104 to S105 are further included:
s104, the glass slide frame turnover mechanism 120 lifts the turned glass slide frame 200;
s105, the slide transport mechanism 130 transports the other slide in the inverted slide frame 200 to the microscopy site.
Thus, the slide frame 200 after being turned is lifted and lowered by the slide frame turning mechanism 120, so that the slide conveying mechanism 130 can switch and convey the slide in the slide frame 200.
In other certain embodiments, the slide transport mechanism 130 can also be controlled to move up and down to switch the transport of slides in the slide frame 200.
Referring to fig. 12, reader 100 optionally further comprises a scanning module block, and the controller is further configured to control the scanning module to implement the following steps:
s201, the slide conveying mechanism 130 conveys the overturned slide in the slide frame 200 to a scanning position;
s202, the scanning module scans the label area of the slide to acquire the label identification information of the slide.
Therefore, the step of scanning the label area of the slide by the scanning module realizes the identification of the label identification information of the slide, and obtains the sample information corresponding to the slide, so that the result of the subsequent microscopic examination is associated with the sample information.
Referring to fig. 13, reader 100 optionally further includes a slide detection mechanism 160, and the controller is further configured to control slide detection mechanism 160 and slide frame flipping mechanism 120 to implement the steps of:
s301, controlling the slide frame overturning mechanism 120 to lift the overturned slide frame 200 or controlling the slide detection mechanism 160 to lift so as to enable the slide frame to be in the detection range of the slide detection mechanism 160;
s302, the slide sensing mechanism 160 senses the slide frame 200 positioned on the slide frame flipping mechanism 120 to obtain the presence and/or position of a slide in the slide frame 200.
Understandably, the slide detecting mechanism 160 is provided beside the slide frame inverting mechanism 120, and after the slide frame inverting mechanism 120 inverts the slide frame 200, the slide frame 200 is controlled to move from top to bottom or bottom to top past the slide sensing mechanism 160, or moving the slide detecting mechanism 160 from top to bottom or from bottom to top, detecting whether a slide is present at each slide location on the slide frame 200, recording the slide location of each slide location on the detection slide frame 200 in the memory, after the detection, the slide is picked up according to the slide placing condition of each slide position from bottom to top or from top to bottom, for example, slide frame 200 has 10 slide placement locations from 1-10, if a slide placement location of 1-7 is detected, the remaining slides are not placed, and only the slide transport mechanism 130 is controlled to pick up the slide at the slide placing position on 1 to 7 at the time of the controlled picking.
In this manner, the step of detecting the slide frame 200 at the detection position by the slide detection mechanism 160 to obtain the presence and/or position of the slide in the slide frame 200 can determine whether the slide is present at the slide position of the slide frame 200, so that the slide transport mechanism 130 can accurately move the slide for transport, preventing the slide transport mechanism 130 from operating empty.
Referring to fig. 14, optionally, after the microscopy mechanism 140 performs microscopy on the slide located at the microscopy site, the following steps are further included:
s106, the slide conveying mechanism 130 conveys the slide after microscopic examination treatment to a slide frame 200 of the slide frame turnover mechanism 120; alternatively, the slide transport mechanism 130 transports the slide after the microscopic examination process to the recovery section.
In this manner, the slide transport mechanism 130 can efficiently process the slide after the microscopic examination.
Optionally, the reader 100 further comprises a feeding mechanism 110, and the controller is further configured to control the feeding mechanism 110 to implement the following steps:
s107, the feeding mechanism 110 conveys the slide frame 200 loaded with the slide to the slide frame inverting mechanism 120.
The foregoing description of the embodiments of the present application has been presented for purposes of illustration and description and is not intended to be exhaustive or limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen in order to best explain the principles of the embodiments, the practical application, or improvements made to the technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Claims (18)

1. A film reader is characterized by comprising:
a feeding mechanism for feeding a slide frame loaded with a slide;
a slide frame inverting mechanism configured to receive the slide frame fed from the feeding mechanism and invert the slide frame;
the glass slide conveying mechanism is used for conveying the glass slides in the turned glass slide frames to a microscopic examination position for microscopic examination;
the microscopic examination mechanism is arranged at the microscopic examination position and is used for microscopic examination of the slide;
a controller configured to control the slide transport mechanism to transport the slide in the slide frame to the microscopy site for microscopy after the slide-frame flipping mechanism flips the slide frame.
2. The slide reader of claim 1 further comprising a slide detection mechanism for detecting the presence or absence of a slide at each of the slide locations in the slide frames of the slide frame flipping mechanism.
3. The slide reader of claim 2 further comprising a drive mechanism for driving the slide frame flipping mechanism up and down to enable the slide transport mechanism to switch the transport of slides in the slide frames.
4. The slide reader of claim 3 wherein the controller is configured to control the drive mechanism to drive the slide frame flipping mechanism to move up and down to detect the presence or absence of a slide on each of the slide locations in the slide frames on the slide frame flipping mechanism via the slide detection mechanism; alternatively, the first and second electrodes may be,
the controller is configured to control the slide sensing mechanism to move up and down to sense the presence or absence of a slide on each slide location in a slide frame on the slide frame flipping mechanism via the slide sensing mechanism.
5. The slide glass reader of claim 1, wherein the slide frame inverting mechanism comprises a receiving structure for receiving a slide frame and a rotating assembly for driving the receiving structure to rotate so as to invert the slide frame.
6. The slide reader of claim 1, further comprising a scanning module;
the slide conveying mechanism is further used for conveying the slide in the turned slide frame to a scanning position, and the scanning module is arranged at the scanning position and used for scanning a label area of the slide to acquire label identification information of the slide.
7. The slide glass reader of claim 1, wherein the slide frame inverting mechanism is configured to rotate the slide frame from an open upward position to a laterally open position.
8. The slide reader of claim 7 wherein the slide frame flipping mechanism is configured to rotate the slide frame 90 degrees from the open up position.
9. The slide reader of claim 1 wherein the slide transport mechanism is further configured to transport a mirrored slide from the mirroring position to a slide frame of the slide frame reversing mechanism; alternatively, the first and second electrodes may be,
the slide conveying mechanism is also used for conveying the slide subjected to the microscopic examination treatment from the microscopic examination position to the recovery area.
10. The reader of claim 1 wherein said slide transport mechanism comprises a slide removal assembly and a drive assembly;
the slide moving assembly is used for moving a slide from the turned slide frame, and the driving assembly is used for driving the slide moving assembly to horizontally move and/or lift so as to enable the slide conveying mechanism to switch and convey the slide in the slide frame and/or enable the slide moving assembly to convey the slide to the microscopic examination position.
11. The slide reader of claim 10 wherein the slide removing assembly comprises a gripping structure and a drive structure; the driving structure is used for driving the clamping structure to open and close so as to clamp or loosen the slide.
12. The slide reader of claim 11 wherein the slide moving assembly is further configured to grip a slide for transport to the microscopy site, and the microscopy mechanism is configured to perform microscopy on the slide gripped by the slide moving assembly at the microscopy site.
13. The reader of claim 10 wherein the slide removal assembly includes a pusher bar, and the drive assembly is configured to drive the pusher bar to push out a slide in the inverted slide frame.
14. A slide reading control method of a slide reader is characterized in that the slide reader comprises a controller, a slide frame overturning mechanism, a slide conveying mechanism and a microscopic examination mechanism, wherein the controller is configured to control the slide frame overturning mechanism, the slide conveying mechanism and the microscopic examination mechanism so as to realize the following steps:
the slide frame overturning mechanism overturns the received slide frame;
the glass slide conveying mechanism conveys the glass slides in the turned glass slide frames to a microscopic examination position;
the microscopic examination mechanism is used for microscopic examination of the slide positioned at the microscopic examination position.
15. The slide reading control method of the slide reading apparatus according to claim 14, wherein after the microscopic examination of the slide at the microscopic examination position by the microscopic examination mechanism, the method further comprises the steps of:
the glass slide frame turnover mechanism lifts the turned glass slide frame;
the slide transport mechanism transports the next slide in the slide frame to the microscopy site.
16. The slide glass reading control method of the slide glass reading apparatus of claim 14, wherein the slide glass reading apparatus further comprises a scanning module, and the controller is further configured to control the scanning module to implement the following steps:
the glass slide conveying mechanism conveys the glass slides in the turned glass slide frames to a scanning position;
the scanning module scans a label area of the slide to obtain label identification information of the slide.
17. The slide reading control method of the slide reading apparatus according to claim 14, wherein after the microscopic examination of the slide at the microscopic examination position by the microscopic examination mechanism, the method further comprises the steps of:
the slide conveying mechanism conveys the slide subjected to microscopic examination treatment to a slide frame of the slide frame turnover mechanism; or the slide conveying mechanism conveys the slide subjected to microscopic examination to the recovery area.
18. The reading control method of the reading apparatus of claim 14, wherein the reading apparatus further comprises a feeding mechanism, and the controller is further configured to control the feeding mechanism to realize the following steps:
the feeding mechanism conveys the slide frame loaded with the slide to the slide frame overturning mechanism.
CN202210607767.5A 2022-05-31 2022-05-31 Film reading instrument and film reading control method thereof Pending CN114942337A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210607767.5A CN114942337A (en) 2022-05-31 2022-05-31 Film reading instrument and film reading control method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210607767.5A CN114942337A (en) 2022-05-31 2022-05-31 Film reading instrument and film reading control method thereof

Publications (1)

Publication Number Publication Date
CN114942337A true CN114942337A (en) 2022-08-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210607767.5A Pending CN114942337A (en) 2022-05-31 2022-05-31 Film reading instrument and film reading control method thereof

Country Status (1)

Country Link
CN (1) CN114942337A (en)

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