CN114939073A - Oral care product for improving remineralization efficiency of enamel as well as preparation method and application thereof - Google Patents
Oral care product for improving remineralization efficiency of enamel as well as preparation method and application thereof Download PDFInfo
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- CN114939073A CN114939073A CN202210635359.0A CN202210635359A CN114939073A CN 114939073 A CN114939073 A CN 114939073A CN 202210635359 A CN202210635359 A CN 202210635359A CN 114939073 A CN114939073 A CN 114939073A
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- China
- Prior art keywords
- phosphate
- oral care
- soluble
- remineralization
- efficiency
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- 210000003298 dental enamel Anatomy 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title abstract description 17
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 55
- 239000011159 matrix material Substances 0.000 claims abstract description 54
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 50
- 239000000606 toothpaste Substances 0.000 claims abstract description 44
- 229940034610 toothpaste Drugs 0.000 claims abstract description 43
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 41
- 239000010452 phosphate Substances 0.000 claims abstract description 40
- 239000000758 substrate Substances 0.000 claims abstract description 36
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 14
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 230000001680 brushing effect Effects 0.000 claims description 7
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 5
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 4
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 4
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 239000004227 calcium gluconate Substances 0.000 claims description 3
- 235000013927 calcium gluconate Nutrition 0.000 claims description 3
- 229960004494 calcium gluconate Drugs 0.000 claims description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 3
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 3
- 235000019797 dipotassium phosphate Nutrition 0.000 claims description 3
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 3
- 239000001488 sodium phosphate Substances 0.000 claims description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 3
- 235000011008 sodium phosphates Nutrition 0.000 claims description 3
- 235000013599 spices Nutrition 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 3
- 239000004254 Ammonium phosphate Substances 0.000 claims description 2
- 239000000120 Artificial Saliva Substances 0.000 claims description 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 claims description 2
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 claims description 2
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims description 2
- 235000019289 ammonium phosphates Nutrition 0.000 claims description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 2
- 239000000920 calcium hydroxide Substances 0.000 claims description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000001527 calcium lactate Substances 0.000 claims description 2
- 229960002401 calcium lactate Drugs 0.000 claims description 2
- 235000011086 calcium lactate Nutrition 0.000 claims description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000292 calcium oxide Substances 0.000 claims description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
- 238000009924 canning Methods 0.000 claims description 2
- 229910000388 diammonium phosphate Inorganic materials 0.000 claims description 2
- 235000019838 diammonium phosphate Nutrition 0.000 claims description 2
- 235000019837 monoammonium phosphate Nutrition 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 2
- 235000011009 potassium phosphates Nutrition 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 2
- 239000003082 abrasive agent Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000010755 mineral Nutrition 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 5
- 235000021317 phosphate Nutrition 0.000 description 33
- 239000000243 solution Substances 0.000 description 19
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 18
- 239000000047 product Substances 0.000 description 18
- 238000003756 stirring Methods 0.000 description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 238000007872 degassing Methods 0.000 description 12
- 239000001768 carboxy methyl cellulose Substances 0.000 description 9
- 239000000230 xanthan gum Substances 0.000 description 9
- 229920001285 xanthan gum Polymers 0.000 description 9
- 235000010493 xanthan gum Nutrition 0.000 description 9
- 229940082509 xanthan gum Drugs 0.000 description 9
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
- 239000000377 silicon dioxide Substances 0.000 description 7
- 235000012239 silicon dioxide Nutrition 0.000 description 7
- 239000000600 sorbitol Substances 0.000 description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 6
- 239000006072 paste Substances 0.000 description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000001506 calcium phosphate Substances 0.000 description 5
- 229910000389 calcium phosphate Inorganic materials 0.000 description 5
- 235000011010 calcium phosphates Nutrition 0.000 description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229960005069 calcium Drugs 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- MKJXYGKVIBWPFZ-CEOVSRFSSA-L calcium;(2s)-2-hydroxypropanoate Chemical compound [Ca+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O MKJXYGKVIBWPFZ-CEOVSRFSSA-L 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940099898 chlorophyllin Drugs 0.000 description 1
- 235000019805 chlorophyllin Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- -1 phosphorus ions Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an oral care product for improving the remineralization efficiency of enamel, and a preparation method and application thereof, and particularly relates to the field of oral care. The oral care implement comprises a substrate comprising a soluble calcium salt, a substrate comprising a soluble phosphate salt, and a container separating the two substrates. When the toothpaste prepared by the invention is used, the matrix containing the soluble calcium salt and the matrix containing the soluble phosphate are simultaneously extruded from the mouth of the toothpaste and are mixed in the oral cavity, so that higher-concentration free calcium ions and free phosphate ions can be provided, the remineralization efficiency of enamel is improved, and the problem that one toothpaste simultaneously contains high-concentration calcium ions and phosphate ions and is easy to react is solved.
Description
Technical Field
The invention relates to the technical field of daily chemical and oral hard tissue medical care, nursing and cleaning products, in particular to a medical and oral cleaning nursing product, and more particularly relates to an oral care product for improving the remineralization efficiency of enamel, and a preparation method and application thereof.
Background
Enamel is the hardest tissue of the human body. Mature enamel contains approximately 96% hydroxyapatite, 3% water, and 1% protein and lipids by weight. As the outermost layer of the tooth, enamel is subject to various physical and chemical attacks such as occlusion, abrasion, and acid erosion from food and bacteria. In general, dissolution of hydroxyapatite at pH < 5.5 leads to demineralization problems of tooth enamel.
Saliva contains calcium ions and phosphate ions with certain concentrations, and the change of the pH value of the saliva can be buffered to a certain extent, so that the dissolution of hydroxyapatite is inhibited. At pH > 5.5 and at higher concentrations of calcium and phosphorus ions, calcium phosphate is formed in the saliva, which remineralizes the demineralized teeth. In general, saliva contains low concentrations of calcium and phosphate ions, and it is difficult to form sufficient amounts of hydroxyapatite to repair demineralized enamel.
The toothpaste added with calcium salt and phosphate can improve the concentration of calcium ions and phosphate ions in the oral cavity during tooth brushing, and is beneficial to the tooth remineralization process. However, when less soluble calcium salts and phosphate salts are added to toothpaste, the calcium ion concentration and phosphate ion concentration can be provided at a lower level. If calcium salt and phosphate with higher solubility are added into the toothpaste, the calcium ions and phosphate ions in the toothpaste rapidly react to form precipitates because the solubility product of calcium phosphate, calcium hydrophosphate, hydroxyapatite and the like is smaller, so that the concentration of free calcium ions and phosphate ions contained in the toothpaste is still lower. Thus, by adding calcium salts and phosphates directly to toothpaste, toothpaste can provide lower concentrations of free calcium and phosphate ions, with limited remineralization rates on enamel for limited brushing times and brushing frequencies.
Disclosure of Invention
Therefore, the invention provides an oral care product for improving the remineralization efficiency of enamel as well as a preparation method and application thereof, and aims to solve the problem that the concentration of free calcium ions and phosphate ions which can be utilized in the existing oral care product is low.
In order to achieve the above purpose, the invention provides the following technical scheme:
according to a first aspect of the present invention there is provided an oral care implement for increasing the efficiency of remineralisation of dental enamel, comprising:
a matrix comprising a soluble calcium salt, a matrix comprising a soluble phosphate salt, and a container separating the two matrices.
The matrix containing soluble calcium salt and the matrix containing soluble phosphate are separately arranged in the unconnected cavities and are extruded simultaneously when the dental enamel remineralization solution is used, so that the two ions do not react before use, and the concentrations of calcium ions and phosphate ions are ensured to the maximum extent, so that better dental enamel remineralization efficiency is achieved.
Further, the soluble calcium salt base comprises a soluble calcium salt and common auxiliary materials for preparing oral care products;
and/or, the matrix containing the soluble phosphate comprises the soluble phosphate and common auxiliary materials for preparing the oral care products.
Further, the soluble calcium salt is a substance which can be dissolved in water and alcohols and can generate free calcium ions. By way of example, the soluble calcium salts include, but are not limited to, one or more of calcium chloride, calcium hydroxide, calcium oxide, calcium nitrate, calcium gluconate, calcium bicarbonate, calcium lactate;
and/or the soluble phosphate is a compound that produces free phosphate, hydrogen phosphate, or dihydrogen phosphate ions, including, by way of example and not limitation, one or more of potassium phosphate, sodium phosphate, ammonium phosphate, potassium monohydrogen phosphate, sodium monohydrogen phosphate, ammonium monohydrogen phosphate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, and ammonium dihydrogen phosphate.
Further, the concentration range of calcium ions in the soluble calcium salt is 0.0001-10 mol/L;
and/or the concentration range of phosphate ions in the soluble phosphate is 0.0001-10 mol/L.
Further, the common auxiliary materials for preparing the oral care product comprise at least one of an abrasive, a humectant, a surfactant, a thickening agent, a sweetening agent, a preservative, an active additive, a spice and water.
The abrasive is one or more of calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, silicon dioxide and aluminum oxide which are commonly used in oral care preparation.
The humectant is one or more of glycerol, sorbitol, propylene glycol and polyethylene glycol.
The surfactant is a surfactant commonly used in preparation of oral care products, and comprises one or more of sodium dodecyl sulfate, sodium 2-acyloxy sulfonate and sodium lauroyl sarcosinate.
The thickening agent is one or more of carboxymethyl cellulose, antler pectin, hydroxyethyl cellulose, xanthan gum, guar gum and carrageenan which are commonly used for preparing oral care products.
The sweetening agent is one or more of common sweetening agents for preparing oral care products, including but not limited to glycerin, sodium cyclamate and saccharin sodium.
Preservatives commonly used preservatives for oral care products are prepared, including but not limited to potassium sorbate and/or sodium benzoate.
The active additive is one or more of bisoxyphenyldiguanidinohexane, cypress alcohol, copper chlorophyllin, stannous fluoride, sodium monofluorophosphate, sodium fluoride and ammonium fluoride which are commonly used for preparing oral care products.
The spice is one or more of menthol, peppermint oil and mint.
Further, the container for separating two substrates is internally divided into two unconnected cavities, and the two cavities share one container nozzle.
Further, the oral care product is a toothpaste or gel.
According to a second aspect of the present invention, there is provided a method of preparing an oral care implement for improving enamel remineralization efficiency as described above, comprising separately canning a substrate comprising a soluble calcium salt and a substrate comprising a soluble phosphate salt in a container having two cavities which are not connected to each other.
Further, the matrix containing the soluble calcium salt is obtained by uniformly mixing the soluble calcium salt with common auxiliary materials for preparing oral care products;
and/or the matrix containing the soluble phosphate is obtained by uniformly mixing the soluble phosphate and common auxiliary materials for preparing the oral care products.
According to a third aspect of the present invention there is provided a method of improving the efficiency of remineralisation of dental enamel by daily brushing using an oral care implement as described above or an oral care implement prepared as described above, or by simulating daily brushing in artificial saliva.
The invention has the following advantages:
the toothpaste tube is filled with the matrix containing soluble calcium salt and the matrix containing soluble phosphate in two separated cavities in the toothpaste tube, and the two cavities are communicated with the tube opening of the toothpaste tube. The soluble calcium salt-containing matrix and the soluble phosphate-containing matrix are not mixed until the toothpaste is used. When the toothpaste is used, the matrix containing the soluble calcium salt and the matrix containing the soluble phosphate are simultaneously extruded from the mouth of the toothpaste and are mixed in the oral cavity, so that high-concentration free calcium ions and free phosphate ions can be provided, the remineralization efficiency of enamel is improved, and the problem that one toothpaste simultaneously contains high-concentration calcium ions and phosphate ions and is easy to react is solved.
The preparation method is simple and easy to implement, and has simple process and strong practicability.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.
The structures, the proportions, the sizes, and the like shown in the specification are only used for matching with the contents disclosed in the specification, so that those skilled in the art can understand and read the present invention, and do not limit the conditions for implementing the present invention, so that the present invention has no technical essence, and any modifications of the structures, changes of the proportion relation, or adjustments of the sizes, should still fall within the scope of the technical contents disclosed in the present invention without affecting the efficacy and the achievable purpose of the present invention.
FIG. 1 is a structural view of a toothpaste according to example 1 of the present invention;
FIG. 2 is a structural view of a toothpaste according to example 2 of the present invention;
in the figure, 1-substrate A cavity, 2-shell cap, 3-substrate B cavity and 4-nozzle.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Example 1
The preparation of matrix a containing soluble calcium salts was as follows:
mixing 20ml of 0.1mol/l calcium chloride solution with 65g of 70 percent sorbitol uniformly and marking the solution 1 for later use; 2g of ethylene glycol is used for sequentially dispersing 0.5g of xanthan gum and 0.6g of sodium carboxymethyl cellulose, the xanthan gum and the sodium carboxymethyl cellulose are uniformly dispersed and poured into the solution 1 at the stirring speed of 50 revolutions per minute to prepare a gel phase;
adding 2g of sodium dodecyl sulfate and 12g of silicon dioxide into the gel phase, placing the gel phase into a paste making pot, stirring at the speed of 300 revolutions per minute, degassing for 40 minutes, adding essence, then continuously stirring and degassing for 5 minutes to obtain a matrix A containing soluble calcium salt;
the preparation of matrix B containing soluble phosphate was as follows:
20ml of dipotassium phosphate solution containing 0.06mol/l is mixed with 65g of 70 percent sorbitol evenly to mark the solution 1 for standby; 2g of ethylene glycol is used for sequentially dispersing 0.5g of xanthan gum and 0.6g of sodium carboxymethyl cellulose, the xanthan gum and the sodium carboxymethyl cellulose are uniformly dispersed and poured into the solution 1 at the stirring speed of 50 revolutions per minute to prepare a gel phase;
adding 2g of sodium dodecyl sulfate and 12g of silicon dioxide into the gel phase, placing the gel phase into a paste making pot, stirring at the speed of 300 revolutions per minute, degassing for 40 minutes, adding essence, continuing stirring, and degassing for 5 minutes to obtain a matrix B containing soluble phosphate;
the preparation method of the toothpaste containing the matrix A containing soluble calcium salt and the matrix B containing soluble phosphate at the same time comprises the following steps:
matrix a containing soluble calcium salt and matrix B containing soluble phosphate salt were filled into the same toothpaste tube. The toothpaste tube is provided with two separated cavities which respectively contain a substrate A containing soluble calcium salt and a substrate B containing soluble phosphate, but the two cavities share one toothpaste tube opening.
As shown in figure 1, the toothpaste comprises a substrate A cavity 1, a substrate B cavity 3 and a shell cap 2, wherein the shell is cylindrical, a double-tube structure is arranged in the shell, namely two cavities are arranged in the toothpaste, the two cavities are separated and extend upwards to a tube opening 4, and the substrate A containing soluble calcium salt is respectively arranged in the substrate A cavity 1; the matrix B containing soluble phosphate is filled into the cavity 3 of the matrix B, and the matrix A containing soluble calcium salt and the matrix B containing soluble phosphate are extruded at the same time when in use.
Example 2
The preparation of matrix a containing soluble calcium salts was as follows:
20ml of 0.5mol/l calcium lactate solution is mixed with 70g of 70 percent sorbitol to be uniformly mixed and marked with solution 1 for standby; dispersing 0.5g of xanthan gum and 0.7g of sodium carboxymethyl cellulose by 3g of ethylene glycol in sequence, uniformly dispersing, and pouring into the solution 1 at a stirring speed of 3000 r/min to prepare a gel phase;
adding 1.5g of sodium dodecyl sulfate and 17g of silicon dioxide into the gel phase, placing the gel phase into a paste making pot, stirring at the speed of 300 revolutions per minute, degassing for 5 minutes, adding essence, continuing stirring, and degassing for 10 minutes to obtain a matrix A containing soluble calcium salt;
the preparation of matrix B containing soluble phosphate was as follows:
20ml of disodium hydrogen phosphate solution containing 0.3mol/l is mixed with 60g of 70 percent sorbitol to be uniformly mixed, and the solution 1 is marked for standby; dispersing 0.4g of xanthan gum and 0.8g of sodium carboxymethylcellulose in 5g of ethylene glycol in sequence, uniformly dispersing, and pouring into the solution 1 at a stirring speed of 300 revolutions per minute to prepare a gel phase;
adding 1.7g of sodium dodecyl sulfate and 20g of silicon dioxide into the gel phase, placing the gel phase into a paste making pot, stirring at the speed of 300 revolutions per minute, degassing for 15 minutes, adding essence, continuing stirring, and degassing for 10 minutes to obtain a matrix B containing soluble phosphate;
the preparation method of the toothpaste containing the matrix A containing soluble calcium salt and the matrix B containing soluble phosphate at the same time comprises the following steps:
matrix a containing soluble calcium salt and matrix B containing soluble phosphate salt were filled into the same toothpaste tube. The toothpaste tube is provided with two separated cavities which respectively contain a substrate A containing soluble calcium salt and a substrate B containing soluble phosphate, but the two cavities share one toothpaste tube opening.
Preferably, as shown in fig. 2, the toothpaste comprises a substrate A cavity 1, a substrate B cavity 3 and a shell cap 2, wherein the shell is cylindrical, and a double-tube structure is arranged inside the shell, namely two cavities are arranged in the toothpaste, the two cavities are separated and extend upwards to a tube opening 4, and the substrate A containing soluble calcium salt is respectively arranged in the substrate A cavity 1; matrix B containing soluble phosphate is filled in the cavity 3 of the matrix B; the matrix A containing soluble calcium salt and matrix B containing soluble phosphate can be directly extruded for use.
Example 3
The preparation of matrix a containing soluble calcium salts was as follows:
mixing 25ml of 0.03mol/l calcium gluconate solution with 55g of 70% sorbitol to uniformly mark the solution 1 for later use; sequentially dispersing 0.9g of xanthan gum and 0.4g of sodium carboxymethylcellulose by using 4g of ethylene glycol, uniformly dispersing, and pouring into the solution 1 at a stirring speed of 1000 rpm to obtain a gel phase;
adding 2.2g of sodium dodecyl sulfate and 20g of silicon dioxide into the gel phase, placing the gel phase into a paste making pot, stirring at the speed of 300 revolutions per minute, degassing for 10 minutes, adding essence, continuing stirring, and degassing for 5 minutes to obtain a matrix A containing soluble calcium salt;
the preparation of matrix B containing soluble phosphate was as follows:
mixing 15ml of sodium phosphate solution containing 0.03mol/l with 65g of 70 percent sorbitol to uniformly mark the solution 1 for later use; dispersing 0.7g of xanthan gum and 0.5g of sodium carboxymethyl cellulose by 5g of ethylene glycol in sequence, uniformly dispersing, and pouring into the solution 1 at a stirring speed of 300 revolutions per minute to prepare a gel phase;
adding 1.8g of sodium dodecyl sulfate and 20g of silicon dioxide into the gel phase, placing the gel phase into a paste making pot, stirring at the speed of 200 revolutions per minute, degassing for 15 minutes, adding essence, continuing stirring, and degassing for 10 minutes to obtain a matrix B containing soluble phosphate;
the preparation method of the toothpaste containing the matrix A containing soluble calcium salt and the matrix B containing soluble phosphate at the same time comprises the following steps:
the matrix a containing soluble calcium salt and the matrix B containing soluble phosphate salt are filled in the same toothpaste tube. The toothpaste tube is provided with two separated cavities which respectively contain a substrate A containing soluble calcium salt and a substrate B containing soluble phosphate, but the two cavities share one toothpaste tube opening.
Preferably, as shown in fig. 2, the toothpaste comprises a substrate a cavity 1, a substrate B cavity 3 and a shell cap 2, the shell is cylindrical, and a double-tube structure is arranged inside the shell, i.e. two cavities are arranged in the toothpaste, the two cavities are separated and extend upwards to a tube opening 4, and the substrate a containing soluble calcium salt is respectively arranged in the substrate a cavity 1; matrix B containing soluble phosphate is filled in the cavity 3 of the matrix B; the matrix A containing soluble calcium salt and matrix B containing soluble phosphate can be directly extruded for use.
Comparative example 1
The present comparative example is different from example 1 in that it is calcium phosphate-containing toothpaste obtained by directly mixing the soluble calcium salt-containing substrate a and the soluble phosphate-containing substrate B obtained in example 1.
Comparative example 2
The present comparative example is different from example 2 in that it is a hydroxyapatite-containing toothpaste obtained by directly and uniformly mixing the soluble calcium salt-containing substrate a and the soluble phosphate salt-containing substrate B obtained in example 2.
Test example
Enamel remineralization experiments:
the tooth enamel modules were brushed 3 times a day for 3 minutes after 15 days using the toothpastes prepared in example 1, example 2, comparative example 1 and comparative example 2, and the tooth enamel modules were cut from the side and the thickness of the growth of the tooth enamel modules was measured under a scanning electron microscope, and the results are shown in table 1.
TABLE 1 comparison of enamel remineralization rates
As can be seen from table 1, the enamel remineralization rate of example 1 is more than 10 times that of the ordinary calcium phosphate toothpaste of comparative example 1; the enamel remineralization rate of example 2 was more than 12 times that of the ordinary calcium phosphate-containing toothpaste of comparative example 2.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. An oral care implement for increasing the efficiency of remineralization of enamel, comprising:
a substrate comprising a soluble calcium salt, a substrate comprising a soluble phosphate salt, and a container separating the two substrates.
2. The method of claim 1, wherein the dental composition further comprises a second ingredient selected from the group consisting of a mineral,
the soluble calcium salt base comprises soluble calcium salt and common auxiliary materials for preparing oral care products;
and/or, the matrix containing the soluble phosphate comprises the soluble phosphate and common auxiliary materials for preparing the oral care products.
3. The oral care implement for enhancing the remineralization efficiency of enamel according to claim 2,
the soluble calcium salt is selected from one or more of calcium chloride, calcium hydroxide, calcium oxide, calcium nitrate, calcium gluconate, calcium bicarbonate and calcium lactate;
and/or the soluble phosphate is selected from one or more of potassium phosphate, sodium phosphate, ammonium phosphate, potassium monohydrogen phosphate, sodium monohydrogen phosphate, ammonium monohydrogen phosphate, potassium dihydrogen phosphate, sodium dihydrogen phosphate and ammonium dihydrogen phosphate.
4. The oral care implement for enhancing the remineralization efficiency of enamel according to claim 3,
the concentration range of calcium ions in the soluble calcium salt is 0.0001-10 mol/L;
and/or the concentration range of phosphate ions in the soluble phosphate is 0.0001-10 mol/L.
5. The oral care implement for enhancing the remineralization efficiency of enamel according to claim 2,
the common auxiliary materials for preparing the oral care product comprise at least one of an abrasive agent, a humectant, a surfactant, a thickening agent, a sweetening agent, a preservative, an active additive, a spice and water.
6. The oral care implement for enhancing the remineralization efficiency of enamel according to claim 1 wherein said container separates two substrates, the interior of the container being divided into two discrete cavities, the two cavities sharing a container nozzle.
7. The oral care implement for increasing the efficiency of remineralization of enamel according to claim 1 wherein said oral care implement is a toothpaste or gel.
8. A method of making an oral care implement for enhancing the remineralization efficiency of enamel according to any one of claims 1 to 7,
respectively canning the substrate containing soluble calcium salt and the substrate containing soluble phosphate in a container with two unconnected cavities.
9. The method of claim 8, wherein the oral care composition is formulated to enhance the remineralization efficiency of enamel,
the matrix containing soluble calcium salt is obtained by uniformly mixing the soluble calcium salt with common auxiliary materials for preparing oral care products;
and/or the matrix containing the soluble phosphate is obtained by uniformly mixing the soluble phosphate and common auxiliary materials for preparing the oral care products.
10. A method of increasing the remineralization efficiency of enamel by daily brushing using an oral care implement according to any one of claims 1 to 7 or an oral care implement prepared by the method according to claim 8 or 9, or by simulating daily brushing in artificial saliva.
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| US20060110340A1 (en) * | 2004-11-24 | 2006-05-25 | American Dental Association Foundation | Compositions and methods for whitening, mineralizing and/or fluoridating calcified tissues |
| JP2007238633A (en) * | 2007-06-25 | 2007-09-20 | Kao Corp | Agent for oral cavity |
| CN101938975A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Dual component oral care product |
| CN111110576A (en) * | 2020-02-13 | 2020-05-08 | 西安科技大学 | Preparation method of dental enamel regeneration composition |
| CN111135104A (en) * | 2020-02-13 | 2020-05-12 | 云南白药集团健康产品有限公司 | Preparation method of toothpaste capable of repairing enamel |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060110340A1 (en) * | 2004-11-24 | 2006-05-25 | American Dental Association Foundation | Compositions and methods for whitening, mineralizing and/or fluoridating calcified tissues |
| JP2007238633A (en) * | 2007-06-25 | 2007-09-20 | Kao Corp | Agent for oral cavity |
| CN101938975A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Dual component oral care product |
| CN111110576A (en) * | 2020-02-13 | 2020-05-08 | 西安科技大学 | Preparation method of dental enamel regeneration composition |
| CN111135104A (en) * | 2020-02-13 | 2020-05-12 | 云南白药集团健康产品有限公司 | Preparation method of toothpaste capable of repairing enamel |
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