CN114938856A - Natural composite powder for removing helicobacter pylori in vivo and preparation method thereof - Google Patents

Natural composite powder for removing helicobacter pylori in vivo and preparation method thereof Download PDF

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Publication number
CN114938856A
CN114938856A CN202210465121.8A CN202210465121A CN114938856A CN 114938856 A CN114938856 A CN 114938856A CN 202210465121 A CN202210465121 A CN 202210465121A CN 114938856 A CN114938856 A CN 114938856A
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weight
parts
powder
helicobacter pylori
traditional chinese
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王英男
韩建春
吴磊
王英鹏
吴春梅
刘丽
王克红
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Harbin Ruikangyuan Biotechnology Co ltd
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Harbin Ruikangyuan Biotechnology Co ltd
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Abstract

The invention relates to natural composite powder for removing helicobacter pylori in vivo and a preparation method thereof, wherein the preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the following steps: preparing mixed traditional Chinese medicine extract of clove, hericium erinaceus, poria cocos, kudzu root, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel and ginger; mixing the powder with fructo-oligosaccharide, yeast beta-dextran, cranberry fruit powder, and bovine colostrum powder to obtain natural composite powder for removing helicobacter pylori in vivo. The invention relates to natural composite powder for removing helicobacter pylori in vivo, which comprises the following components: fructo-oligosaccharide, yeast beta-glucan, cranberry fruit powder, bovine colostrum powder and the rest of mixed traditional Chinese medicines in parts by weight, wherein the mixed traditional Chinese medicines comprise clove, hericium erinaceus, poria cocos, radix puerariae, lotus root starch, glutinous rice flour, cinnamon, fennel, nutmeg, dried orange peel and ginger. The technical scheme of the invention achieves the ideal aims of eliminating helicobacter pylori, reducing the generation of side effects and realizing the supplement of nutritional functions to the maximum extent.

Description

Natural composite powder for removing helicobacter pylori in vivo and preparation method thereof
Technical Field
The invention relates to a health food, in particular to natural composite powder for removing helicobacter pylori in vivo and a preparation method thereof.
Background
In 1982, H.pylori (Hp) was discovered by Australian scholarly. Hp colonizes under and between the gastric and gastric mucosal epithelium, invades mucosal epithelial cells, destroys mucosal integrity, and produces various toxic substances, leading to inflammatory necrosis of cells. The diseases associated with helicobacter pylori include chronic gastritis, gastric ulcer, duodenal ulcer, gastric lymphoma, gastric cancer, etc. It has been found that about 60% to 80% of patients with gastric ulcers and more than 95% of patients with duodenal bulbar ulcers are associated with infection by helicobacter pylori at the same time. If the patients with peptic ulcer do not completely eradicate helicobacter pylori, the ulcer can repeatedly attack, and obstruction, perforation, bleeding and even cancerization can be caused after a long time. Hp has been identified by the world health organization as a class I carcinogen, clearly indicating that Hp is an important cause of gastric cancer. In addition, Hp may cause other diseases such as cardiovascular disease, anemia, and idiopathic thrombocytopenic purpura. The international world health organization has identified helicobacter pylori as the first cause of gastric cancer. The existing method for removing helicobacter pylori mostly adopts a quadruple therapy (namely, the combined use of four antibiotics), which not only can cause allergic reactions such as rash and urticaria, but also can cause gastrointestinal reactions such as gastrectasia, stomachache or dyspepsia and inappetence, and also can cause symptoms of nerve functions such as dizziness, headache, nausea or somnolence. And also can cause blood liquid diseases, such as granulocytopenia, and cannot achieve the effects of safely, comprehensively and effectively removing helicobacter pylori and repairing gastric mucosa. According to statistics, the Hp infection rate of China is about 40-70%, which is higher than that of developed countries, the detection rate of Hp in stomach disease patients is far higher than that of common people, about 80-90%, and a pure natural product for safely removing helicobacter pylori brings more health and safety to people.
Disclosure of Invention
The invention aims to provide natural composite powder for removing helicobacter pylori in vivo and a preparation method thereof.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the following steps:
A. preparing clove, hericium erinaceus, poria cocos, kudzu vine root, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel, ginger, arabinogalactan, fructooligosaccharide, isomaltooligosaccharide, yeast beta-glucan, epigallocatechin gallate, cranberry fruit powder, bovine colostrum powder, lactoferrin, lactobacillus reuteri and dihydroquercetin;
B. preparing the mixed traditional Chinese medicine extract of clove, hericium erinaceus, poria cocos, radix puerariae, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel and ginger in equal parts by weight;
C. b, concentrating the traditional Chinese medicine extracting solution obtained in the step B;
D. c, spreading the traditional Chinese medicine extracting solution obtained in the step C into a freeze-drying chamber at the temperature of-80 ℃ for low-temperature drying;
E. d, crushing the dried substance obtained in the step D, and filtering the crushed substance through a 120-mesh sieve to obtain powder;
F. and E, mixing 1 weight part of fructo-oligosaccharide, 0.8-1.2 weight parts of yeast beta-glucan, 0.8-1.2 weight parts of cranberry fruit powder, 0.8-1.2 weight parts of bovine colostrum powder, 0.8-1.2 weight parts of lactoferrin, 0.8-1.2 weight parts of inulin, 0.8-1.2 weight parts of isomaltooligosaccharide, 0.8-1.2 weight parts of arabinogalactan, 0.08-0.12 weight parts of dihydroquercetin, 0.08-0.12 weight parts of lactobacillus reuteri and 0.08-0.12 weight parts of epigallocatechin gallate to obtain the natural composite powder for removing helicobacter pylori in vivo.
The invention discloses a preparation method of natural composite powder for removing helicobacter pylori in vivo, wherein the step B comprises the following steps: selecting equal parts by weight of moldy and rotten-free, worm-eaten-free and dried clove, hericium erinaceus, poria cocos, radix puerariae, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried tangerine peel and dried ginger, cleaning and crushing, mixing crushed mixed materials 0.8-1.2 parts by weight with 18-22 parts by weight of water, putting the mixed materials into an extraction bottle, putting the extraction bottle into a normal-temperature ultrahigh-pressure extractor, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 min/time, pouring out traditional Chinese medicine extracting solution from the extraction bottle, adding 18-22 parts by weight of water into the extraction bottle again, mixing, putting the extraction bottle into the normal-temperature ultrahigh-pressure extractor, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 min/time, taking out the extraction bottle, pouring out the traditional Chinese medicine extracting solution from the extraction bottle, repeating the extraction for 2-6 times, and filtering to obtain Chinese medicinal extractive solution.
The invention discloses a preparation method of natural composite powder for removing helicobacter pylori in vivo, wherein the step C comprises the following steps: and D, selecting membrane packages with different molecular weights of 20-500nm from the traditional Chinese medicine extracting solution obtained in the step B, and concentrating by using a graded vibration membrane.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the step C of selecting the traditional Chinese medicine extracting solution obtained in the step B from membranes with different molecular weights of 20-100nm, 100-300nm and 450-500nm and concentrating by using a graded vibrating membrane.
The invention discloses a preparation method of natural composite powder for removing helicobacter pylori in vivo, wherein step D is to flatly spread 19-21 parts by weight of traditional Chinese medicine extracting solution obtained in step C into a freeze-drying chamber at the temperature of-80 ℃ for low-temperature drying.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the step E of collecting the dried substance obtained in the step D, putting the dried substance into a convection crusher, crushing by adopting 4000-9000 convection, and filtering by a 120-mesh sieve to obtain powder.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the step F of mixing 1 part by weight of the powder obtained in the step E, 0.9-1.1 part by weight of fructo-oligosaccharide, 0.9-1.1 part by weight of yeast beta-glucan, 0.9-1.1 part by weight of cranberry fruit powder, 0.9-1.1 part by weight of bovine colostrum powder, 0.9-1.1 part by weight of lactoferrin, 0.9-1.1 part by weight of inulin, 0.9-1.1 part by weight of isomaltooligosaccharide, 0.9-1.1 part by weight of arabinogalactan, 0.09-0.11 part by weight of dihydroquercetin, 0.09-0.11 part by weight of lactobacillus reuteri and 0.09-0.11 part by weight of epigallocatechin gallate, so as to obtain the natural composite powder for removing helicobacter pylori in vivo.
The invention relates to natural composite powder for removing helicobacter pylori in vivo, which comprises the following components: 0.8-1.2 parts of fructo-oligosaccharide, 0.8-1.2 parts of yeast beta-glucan, 0.8-1.2 parts of cranberry fruit powder, 0.8-1.2 parts of bovine colostrum powder, 0.8-1.2 parts of lactoferrin, 0.8-1.2 parts of inulin, 0.8-1.2 parts of isomaltooligosaccharide, 0.8-1.2 parts of arabinogalactan, 0.08-0.12 parts of dihydroquercetin, 0.08-0.12 parts of lactobacillus reuteri, 0.08-0.12 parts of epigallocatechin gallate and 1 part of mixed traditional Chinese medicine by weight, wherein the mixed traditional Chinese medicine comprises clove, hericium erinaceus, poria cocos, kudzu root, lotus root starch, sticky rice powder, common fennel, nutmeg, dried orange peel and ginger in equal parts by weight.
The invention relates to natural composite powder for removing helicobacter pylori in vivo, which comprises the following components: 0.9-1.1 weight parts of fructo-oligosaccharide, 0.9-1.1 weight parts of yeast beta-glucan, 0.9-1.1 weight parts of cranberry fruit powder, 0.9-1.1 weight parts of bovine colostrum powder, 0.9-1.1 weight parts of lactoferrin, 0.9-1.1 weight parts of inulin, 0.9-1.1 weight parts of isomaltooligosaccharide, 0.9-1.1 weight parts of arabinogalactan, 0.09-0.11 weight parts of dihydroquercetin, 0.09-0.11 weight parts of lactobacillus reuteri, 0.09-0.11 weight parts of epigallocatechin gallate and 1 weight part of mixed traditional Chinese medicine, wherein the mixed traditional Chinese medicine comprises clove extract, hericium erinaceum extract, poria cocos extract, kudzu root extract, lotus root powder extract, glutinous rice flour extract, cinnamon extract, fennel extract, myristica nutmeg extract, dried orange peel extract and the same weight parts of mixed traditional Chinese medicine, Ginger extract.
The invention relates to natural composite powder for removing helicobacter pylori in vivo, which comprises the following components: 1.0 part by weight of fructo-oligosaccharide, 1.0 part by weight of yeast beta-glucan, 1.0 part by weight of cranberry fruit powder, 1.0 part by weight of bovine colostrum powder, 1.0 part by weight of lactoferrin, 1.0 part by weight of inulin, 1.0 part by weight of isomaltooligosaccharide, 1.0 part by weight of arabinogalactan, 0.1 part by weight of dihydroquercetin, 0.1 part by weight of lactobacillus reuteri, and 0.1 part by weight of epigallocatechin gallate.
The technical scheme of the invention is that rare plants are used as raw materials, various natural bioactive substances are extracted by processes of normal-temperature ultrahigh-pressure extraction, molecular vibration membrane concentration, ultralow-temperature freeze-drying, low-temperature convection crushing and the like, and the natural bioactive substances are compounded and processed into the health-care food. The technical scheme of the invention follows the concept of taking food as medicine and taking food as main, and the ideal aims of eliminating helicobacter pylori, reducing the generation of side effects and realizing nutritional function supplement are achieved to the maximum extent.
The technical scheme of the invention utilizes the spicy plants to extract the functional components to eliminate the helicobacter pylori infection source; the cranberry fruit powder, the hericium erinaceus, the bovine colostrum powder and the lactoferrin are added to block the helicobacter pylori Homb protein, the helicobacter pylori Homb protein is wrapped and taken out of a body, and the propagation path is cut off; the nonspecific immune response capability of organisms is improved through the plant polysaccharide, the prebiotics and the dihydroquercetin, and susceptible people are protected, so that the helicobacter pylori is completely eradicated.
Detailed Description
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the following steps:
A. preparing clove, hericium erinaceus, poria cocos, kudzu vine root, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel, ginger, arabinogalactan, fructo-oligosaccharide, isomalto-oligosaccharide, yeast beta-glucan, epigallocatechin gallate, cranberry fruit powder, bovine colostrum powder, lactoferrin, lactobacillus reuteri and dihydroquercetin;
B. preparing the mixed traditional Chinese medicine extract of clove, hericium erinaceus, poria cocos, radix puerariae, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel and ginger in equal parts by weight;
C. b, concentrating the traditional Chinese medicine extracting solution obtained in the step B;
D. c, spreading the traditional Chinese medicine extracting solution obtained in the step C into a freeze-drying chamber at the temperature of-80 ℃ for low-temperature drying;
E. d, crushing the dried substance obtained in the step D, and filtering the crushed substance through a 120-mesh sieve to obtain powder;
F. and E, mixing 1 weight part of fructo-oligosaccharide, 0.8-1.2 weight parts of yeast beta-glucan, 0.8-1.2 weight parts of cranberry fruit powder, 0.8-1.2 weight parts of bovine colostrum powder, 0.8-1.2 weight parts of lactoferrin, 0.8-1.2 weight parts of inulin, 0.8-1.2 weight parts of isomaltooligosaccharide, 0.8-1.2 weight parts of arabinogalactan, 0.08-0.12 weight parts of dihydroquercetin, 0.08-0.12 weight parts of lactobacillus reuteri and 0.08-0.12 weight parts of epigallocatechin gallate to obtain the natural composite powder for removing helicobacter pylori in vivo.
The invention discloses a preparation method of natural composite powder for removing helicobacter pylori in vivo, wherein the step B comprises the following steps: selecting equal parts by weight of moldy and rotten-free, worm-eaten-free and dried clove, hericium erinaceus, poria cocos, radix puerariae, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried tangerine peel and dried ginger, cleaning and crushing, mixing crushed mixed materials 0.8-1.2 parts by weight with 18-22 parts by weight of water, putting the mixed materials into an extraction bottle, putting the extraction bottle into a normal-temperature ultrahigh-pressure extractor, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 min/time, pouring out traditional Chinese medicine extracting solution from the extraction bottle, adding 18-22 parts by weight of water into the extraction bottle again, mixing, putting the extraction bottle into the normal-temperature ultrahigh-pressure extractor, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 min/time, taking out the extraction bottle, pouring out the traditional Chinese medicine extracting solution from the extraction bottle, repeating the extraction for 2-6 times, and filtering to obtain Chinese medicinal extractive solution.
The invention discloses a preparation method of natural composite powder for removing helicobacter pylori in vivo, wherein the step C comprises the following steps: and D, selecting membrane packages with different molecular weights of 20-500nm from the traditional Chinese medicine extracting solution obtained in the step B, and concentrating by using a graded vibration membrane.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the step C of selecting the traditional Chinese medicine extracting solution obtained in the step B from membranes with different molecular weights of 20-100nm, 100-300nm and 450-500nm and concentrating by using a graded vibrating membrane.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the step D of flatly spreading 19-21 parts by weight of the traditional Chinese medicine extracting solution obtained in the step C into a freeze-drying chamber with the temperature of-80 ℃ for low-temperature drying.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the step E of collecting the dried substance obtained in the step D, putting the dried substance into a convection crusher, crushing by adopting 4000-9000 convection, and filtering by a 120-mesh sieve to obtain powder.
The preparation method of the natural composite powder for removing helicobacter pylori in vivo comprises the step F of mixing 1 part by weight of the powder obtained in the step E, 0.9-1.1 part by weight of fructo-oligosaccharide, 0.9-1.1 part by weight of yeast beta-glucan, 0.9-1.1 part by weight of cranberry fruit powder, 0.9-1.1 part by weight of bovine colostrum powder, 0.9-1.1 part by weight of lactoferrin, 0.9-1.1 part by weight of inulin, 0.9-1.1 part by weight of isomaltooligosaccharide, 0.9-1.1 part by weight of arabinogalactan, 0.09-0.11 part by weight of dihydroquercetin, 0.09-0.11 part by weight of lactobacillus reuteri and 0.09-0.11 part by weight of epigallocatechin gallate, so as to obtain the natural composite powder for removing helicobacter pylori in vivo.
The invention relates to natural composite powder for removing helicobacter pylori in vivo, which comprises the following components: 0.8-1.2 parts of fructo-oligosaccharide, 0.8-1.2 parts of yeast beta-glucan, 0.8-1.2 parts of cranberry fruit powder, 0.8-1.2 parts of bovine colostrum powder, 0.8-1.2 parts of lactoferrin, 0.8-1.2 parts of inulin, 0.8-1.2 parts of isomaltooligosaccharide, 0.8-1.2 parts of arabinogalactan, 0.08-0.12 parts of dihydroquercetin, 0.08-0.12 parts of lactobacillus reuteri, 0.08-0.12 parts of epigallocatechin gallate and 1 part of mixed traditional Chinese medicine by weight, wherein the mixed traditional Chinese medicine comprises clove, hericium erinaceus, poria cocos, kudzu root, lotus root starch, sticky rice powder, common fennel, nutmeg, dried orange peel and ginger in equal parts by weight.
The invention relates to natural composite powder for removing helicobacter pylori in vivo, which comprises the following components: 0.9-1.1 weight parts of fructo-oligosaccharide, 0.9-1.1 weight parts of yeast beta-glucan, 0.9-1.1 weight parts of cranberry fruit powder, 0.9-1.1 weight parts of bovine colostrum powder, 0.9-1.1 weight parts of lactoferrin, 0.9-1.1 weight parts of inulin, 0.9-1.1 weight parts of isomaltooligosaccharide, 0.9-1.1 weight parts of arabinogalactan, 0.09-0.11 weight parts of dihydroquercetin, 0.09-0.11 weight parts of lactobacillus reuteri, 0.09-0.11 weight parts of epigallocatechin gallate and 1 weight part of mixed traditional Chinese medicine, wherein the mixed traditional Chinese medicine comprises clove extract, hericium erinaceum extract, poria cocos extract, kudzu root extract, lotus root powder extract, glutinous rice flour extract, cinnamon extract, fennel extract, myristica nutmeg extract, dried orange peel extract and the same weight parts of mixed traditional Chinese medicine, Ginger extract.
The invention relates to natural composite powder for removing helicobacter pylori in vivo, which comprises the following components: 1.0 part by weight of fructo-oligosaccharide, 1.0 part by weight of yeast beta-glucan, 1.0 part by weight of cranberry fruit powder, 1.0 part by weight of bovine colostrum powder, 1.0 part by weight of lactoferrin, 1.0 part by weight of inulin, 1.0 part by weight of isomaltooligosaccharide, 1.0 part by weight of arabinogalactan, 0.1 part by weight of dihydroquercetin, 0.1 part by weight of lactobacillus reuteri, and 0.1 part by weight of epigallocatechin gallate.
The technical scheme of the invention is that rare plants are used as raw materials, various natural bioactive substances are extracted by processes of normal-temperature ultrahigh-pressure extraction, molecular vibration membrane concentration, ultralow-temperature freeze-drying, low-temperature convection crushing and the like, and the natural bioactive substances are compounded and processed into the health-care food. The technical scheme of the invention follows the concept of taking food as medicine and taking food as main, and the ideal aims of eliminating helicobacter pylori, reducing the generation of side effects and realizing nutritional function supplement are achieved to the maximum extent.
The technical scheme of the invention utilizes the spicy plants to extract the functional components to eliminate the helicobacter pylori infection source; the cranberry fruit powder, the hericium erinaceus, the bovine colostrum powder and the lactoferrin are added to block the helicobacter pylori Homb protein, the helicobacter pylori Homb protein is wrapped and taken out of a body, and the propagation path is cut off; the nonspecific immune response capability of organisms is improved through the plant polysaccharide, the prebiotics and the dihydroquercetin, and susceptible people are protected, so that the helicobacter pylori is completely eradicated.
The natural composite powder for removing helicobacter pylori in vivo is prepared by extracting various natural bioactive substances from rare plants serving as raw materials through processes of normal-temperature ultrahigh-pressure extraction, molecular vibration membrane concentration, ultralow-temperature freeze drying, low-temperature convection crushing and the like, and compounding the natural bioactive substances with beneficial substances such as prebiotics, prebiotics and the like.
The international world health organization has identified helicobacter pylori as the first cause of gastric cancer. The existing method for removing the helicobacter pylori mostly adopts a quadruple therapy (namely, the combined use of four antibiotics), which not only can cause allergic reactions such as rash and urticaria, gastrointestinal reactions such as gastrectasia, stomachache or dyspepsia and inappetence, but also can cause symptoms of nerve functions such as dizziness, headache, nausea or somnolence, and the like, but also can possibly cause hemorrheolic diseases such as granulocytopenia, and cannot achieve the effects of safely, comprehensively and effectively removing the helicobacter pylori and repairing gastric mucosa. According to statistics, the Hp infection rate of China is about 40-70%, which is higher than that of developed countries, and the detection rate of Hp in stomach disease patients is far higher than that of common people, which is about 80-90%.
The technical scheme of the invention adopts a normal-temperature ultrahigh-pressure extraction technology and a graded vibrating membrane concentration technology to screen rare spicy plants, and functional components in the rare spicy plants are extracted to eliminate helicobacter pylori infection sources; the cranberry fruit powder, the hericium erinaceus, the bovine colostrum powder and the lactoferrin are added to block the helicobacter pylori Homb protein, the helicobacter pylori Homb protein is wrapped and taken out of a body, and the propagation path is cut off; the nonspecific immune response capability of organisms is improved through the plant polysaccharide, the prebiotics and the dihydroquercetin, and susceptible people are protected, so that the helicobacter pylori is completely eradicated.
The invention adopts the vibration membrane separation concentration process to treat the extracting solution, thereby realizing the effects of microfiltration, ultrafiltration and nanofiltration to remove impurities and concentrate, replacing the 'alcohol precipitation and impurity removal' and 'static membrane concentration' used in the processes of removing impurities and concentrating after the conventional hot water extraction, reducing the organic pollution of the environment and avoiding the problem that the extraction efficiency is influenced by the blockage of the static membrane.
Clove, hericium erinaceus, poria cocos, kudzu vine root, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel, ginger, arabinogalactan, fructo-oligosaccharide, isomaltooligosaccharide, yeast beta-glucan, epigallocatechin gallate, cranberry fruit powder, bovine colostrum powder, lactoferrin, lactobacillus reuteri, dihydroquercetin and other active ingredients, the effect of removing helicobacter pylori is ideal, but as various bioactive substances of the active ingredients belong to heat-sensitive ingredients and cannot be extracted at high temperature, the active ingredients can be effectively extracted by adopting an extraction process of repeatedly extracting for 2-6 times at 580Mpa-620Mpa normal-temperature and ultrahigh-pressure extraction time of 8-40 minutes/time.
The invention adopts the high-low temperature freeze drying and low-temperature convection crushing processes to dry and crush the extracting solution, ensures that the raw materials are processed in the whole process by adopting the low-temperature process, and does not damage the components of bioactive substances.
The technical scheme of the invention can effectively retain bioactive substances in the powder, so that the composite powder can effectively block the helicobacter pylori Homb protein, wrap the helicobacter pylori Homb protein out of a body and cut off a propagation path; the nonspecific immune response capability of organisms is improved through the plant polysaccharide, the prebiotics and the dihydroquercetin, susceptible people are protected, the helicobacter pylori is thoroughly eradicated, the nutritive value and the action function are more obvious, the effects of removing the helicobacter pylori in vivo and repairing gastric mucosa are achieved, and the natural, safe and thorough characteristics are achieved.
The natural helicobacter pylori-removing composite powder and the preparation method thereof are further explained below.
The natural composite powder is prepared by the following steps:
A. preparing raw materials including clove, hericium erinaceus, poria cocos, kudzu root, lotus root starch, glutinous rice flour, cinnamon, fennel, nutmeg, dried orange peel, ginger, arabinogalactan, fructo-oligosaccharide, isomalto-oligosaccharide, yeast beta-glucan, epigallocatechin gallate, cranberry fruit powder, bovine colostrum powder, lactoferrin, lactobacillus reuteri and dihydroquercetin;
B. selecting and cleaning and crushing the same weight parts of dried clove, hericium erinaceus, poria cocos, kudzu vine root, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel and ginger, adding 18-22 weight parts of water into the crushed traditional Chinese medicine according to the proportion of 0.8-1.2 weight parts of crushed traditional Chinese medicine, putting the mixture into an extraction bottle, putting the extraction bottle into a normal-temperature ultrahigh-pressure extractor, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 minutes/time, taking out the extraction bottle, pouring out the traditional Chinese medicine extracting solution from the extraction bottle, adding 18-22 weight parts of water into the extraction bottle again, putting the extraction bottle into the normal-temperature ultrahigh-pressure extractor after mixing, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 minutes/time, then taking out the extraction bottle, pouring out the Chinese medicinal extractive solution from the extraction bottle, repeating the extraction for 2-6 times, and filtering to obtain Chinese medicinal extractive solution;
C. b, selecting membrane packages with different molecular weights of 20-500nm from the traditional Chinese medicine extracting solution obtained in the step B, and concentrating by adopting a graded vibration membrane for later use;
D. c, spreading 18-22 parts by weight of the traditional Chinese medicine extracting solution obtained in the step C in a freeze-drying chamber at the temperature of-80 ℃ for low-temperature drying;
E. d, collecting the dried substance obtained in the step D, putting the dried substance into a convection crusher, adopting 3000-10000 convection crushing, and filtering a 120-mesh sieve to obtain powder for later use;
F. and E, mixing 1 weight part of fructo-oligosaccharide, 0.8-1.2 weight parts of yeast beta-glucan, 0.8-1.2 weight parts of cranberry fruit powder, 0.8-1.2 weight parts of bovine colostrum powder, 0.8-1.2 weight parts of lactoferrin, 0.8-1.2 weight parts of inulin, 0.8-1.2 weight parts of isomaltooligosaccharide, 0.8-1.2 weight parts of arabinogalactan, 0.08-0.12 weight parts of dihydroquercetin, 0.08-0.12 weight parts of lactobacillus reuteri and 0.08-0.12 weight parts of epigallocatechin gallate to obtain a finished product of the compound powder with the helicobacter pylori naturally removed.
As a further improvement of the invention, in the step B, 19-21 parts by weight of water is added into 0.9-1.1 part by weight of crushed traditional Chinese medicine and mixed and put into an extraction bottle, the extraction bottle is put into a normal temperature and ultrahigh pressure extractor, normal temperature and ultrahigh pressure extraction is carried out at a constant pressure of 590Mpa-610Mpa for 9-11 minutes/time, then the extraction bottle is taken out, the traditional Chinese medicine extracting solution is poured out of the extraction bottle, 19-21 parts by weight of water is added into the extraction bottle again, after mixing, the extraction bottle is put into the normal temperature and ultrahigh pressure extractor, normal temperature and ultrahigh pressure extraction is carried out at a constant pressure of 590-610 Mpa for 9-11 minutes/time, then the extraction bottle is taken out, the traditional Chinese medicine extracting solution is poured out of the extraction bottle, and the traditional Chinese medicine extracting solution is extracted 3-5 times repeatedly in this way, and the obtained traditional Chinese medicine extracting solution is filtered, standby;
in the step C, the traditional Chinese medicine extracting solution obtained in the step B is selected from membrane packages with different molecular weights of 20-100nm, 100-300nm and 450-500nm and is concentrated by adopting a graded vibrating membrane for later use;
d, flatly spreading the 19-21 parts by weight of the traditional Chinese medicine extracting solution obtained in the step C into a freeze-drying chamber at the temperature of-80 ℃ for low-temperature drying;
step E, collecting the dried substance obtained in the step D, putting the dried substance into a convection crusher, performing 4000-9000 convection crushing, and filtering by a 120-mesh sieve to obtain powder for later use;
and step F, mixing 1 weight part of the powder obtained in the step E, 0.9-1.1 weight part of fructo-oligosaccharide, 0.9-1.1 weight part of yeast beta-glucan, 0.9-1.1 weight part of cranberry fruit powder, 0.9-1.1 weight part of bovine colostrum powder, 0.9-1.1 weight part of lactoferrin, 0.9-1.1 weight part of inulin, 0.9-1.1 weight part of isomaltooligosaccharide, 0.9-1.1 weight part of arabinogalactan, 0.09-0.11 weight part of dihydroquercetin, 0.09-0.11 weight part of lactobacillus reuteri and 0.09-0.11 weight part of epigallocatechin gallate to obtain a finished product of the natural helicobacter pylori-removed composite powder.
As a further improvement of the invention, in the step B, 20 parts by weight of water is added to 1 part by weight of the crushed traditional Chinese medicines, the mixture is placed in an extraction bottle, the extraction bottle is placed in a normal-temperature ultrahigh-pressure extractor, normal-temperature ultrahigh-pressure extraction is carried out at a constant pressure of 600Mpa, the extraction time of normal-temperature ultrahigh pressure is 10 minutes/time, then the extraction bottle is taken out, the traditional Chinese medicine extracting solution is poured out of the extraction bottle, then 20 parts by weight of water is added to the extraction bottle again, the extraction bottle is placed in the normal-temperature ultrahigh-pressure extractor after mixing, normal-temperature ultrahigh-pressure extraction is carried out at a constant pressure of 600Mpa, the extraction time of normal-temperature ultrahigh pressure is 10 minutes/time, then the extraction bottle is taken out, the traditional Chinese medicine extracting solution is poured out of the extraction bottle, and the traditional Chinese medicine extracting solution is repeatedly extracted for 3-4 times and filtered for later use;
in the step C, membrane packages with different molecular weights of 80nm, 200nm and 450nm are selected from the traditional Chinese medicine extracting solution obtained in the step B, and are concentrated by adopting a graded vibration membrane for later use;
step D, spreading 20 parts by weight of the traditional Chinese medicine extracting solution obtained in the step C into a freeze-drying chamber at the temperature of minus 80 ℃ for low-temperature drying;
d, collecting the dried substances obtained in the step D, putting the dried substances into a convection crusher, performing 6000-turn convection crushing, and filtering a 120-mesh sieve to obtain powder for later use;
and step F, mixing the powder obtained in the step E, 1.0 weight part of fructo-oligosaccharide, 1.0 weight part of yeast beta-glucan, 1.0 weight part of cranberry fruit powder, 1.0 weight part of bovine colostrum powder, 1.0 weight part of lactoferrin, 1.0 weight part of inulin, 1.0 weight part of isomaltooligosaccharide, 1.0 weight part of arabinogalactan, 0.1 weight part of dihydroquercetin, 0.1 weight part of lactobacillus reuteri and 0.1 weight part of epigallocatechin gallate to obtain a finished product of the natural helicobacter pylori-removed composite powder.
The functional test of the natural helicobacter pylori removing composite powder selects SPF-level SD rats (with the weight of 140-. After animal quarantine is qualified, the animals are randomly divided into 6 groups of blank control group, model control group, positive control group, formula group low and high dose group, 10 groups/group according to body weight. The experiment was carried out in 2 batches of 5 each, 1 batch, 2 batches separated by 1 day. Wherein the low and high dosages of the formula are respectively 10 and 30 times of the human recommended amount of the natural composite powder.
And (3) intragastrically administering a test sample with a corresponding formula according to 10mL/kg body weight every day, intragastrically administering sucralfate oral suspension to a positive control group by the same method, and intragastrically administering a solvent to a blank control group and a model control group by the same method for 1 time/d, and continuously administering for 30 days. After the last dose, all animals were strictly fasted for 24 h. Except for a blank control group, the other animals in each group are subjected to intragastric administration of absolute ethyl alcohol, the intragastric volume is 1.0 mL/animal, the animals are euthanized after being subjected to intragastric administration of ethanol for 1h, cardia is ligated, 8mL of 10% neutral formaldehyde solution is injected from a pylorus of the stomach, suture ligation is performed, the filled stomach body is cut, the stomach body is soaked in 5% formaldehyde solution, fixation is performed for 20min, then the appetizing wall is cut along the lesser curvature of the stomach, the stomach mucosa is unfolded after contents are cleaned away from a bleeding zone and the content is cut along the greater curvature of the stomach, and corresponding index detection is performed. After the gastric mucosa was developed, the length and width of the bleeding point or band were visually measured with a vernier caliper, and the score was calculated as shown in table 1 to obtain the total score, and the incidence of injury (%), the index of injury score and the inhibition of injury were calculated according to the following formulas.
The incidence of injury (%) - (number of rats with bleeding or ulceration in a group/number of rats in the group X100%
Injury score index-group injury score sum/number of animals in group
The injury inhibition rate (%) is (model control injury integral-test substance group injury integral)/model control injury integral x 100%
All data are expressed as (XS), statistical analysis is performed using SPSS21.0 software; analyzing the body weight by repeated measurement variance; visual observation scores and histopathological scores were analyzed by variance: performing T test on the blank control group and the model control group, and performing variance analysis on each administration group separately with the model control group and the positive control group; the incidence of damage was examined using chi-square. The test level α is 0.05.
Compared with a model control group, the damage incidence rate and the damage integral index of the positive control group and the formula group are reduced, wherein the damage inhibition rates of the positive control group and the formula group in the low-dosage and high-dosage groups are respectively 46.2%, 20.7% and 62.5%, which shows that the formula group can reduce the incidence rate and the damage integral index of gastric mucosa damage to a certain extent, and the result of increasing the damage inhibition rate is shown in table 1. As can be seen from Table 2, the gastric mucosa of the model group rats had severe congestion, hemorrhage and epithelial cell necrosis, and the histopathological score of the gastric mucosa injury was increased. The congestion, bleeding and epithelial cell necrosis of the gastric mucosa of the rat in the high-dose group of the formula are all reduced, and the damage score is all obviously reduced. The formula group has different degrees of protection effects on the gastric mucosa, so that the acute injury of the gastric mucosa is relieved.
TABLE 1 results of acute injury visual observation and scoring
Group of n Dose/(g/kg) Visual evaluation of scores Incidence of damage/%) Integral index of damage Wound inhibition rate/%)
Blank control group 10 —— 0 ** 0 ** 0 100
Model control group 10 —— 35.3±8.4 100 35.3 /
Positive control group 10 6.7mL/kg 19.0±11.2** 90 19 46.2
Formulation ofGroup Low dose 10 0.48 41.5±16.0 80 28.5 20.7
Formula group high dose 10 1.46 21.6±18.4* 90 16 62.5
Note: p < 0.05, P < 0.01 compared to model control.
TABLE 2 histopathological examination of gastric mucosa
Figure BDA0003623629460000121
Note: p < 0.05, P < 0.01 compared to model control.
Ulcer formation is caused by various factors, such as infection with HP, hypersecretion of gastric acid, damage to gastric mucosa, etc., and among them, infection with HP is the most important cause of gastric ulcer. Its main mechanism is: inflammation following HP infection causes damage to the gastric mucosa, which is not effective against the low acidity in the stomach causing ulcers. The results of pharmacodynamic experiments in vivo of the natural helicobacter pylori-removing composite powder show that the composite powder has the function of reducing ulcer indexes for various experimental animal gastric ulcer models, and the inhibition rate shows dose effect correlation. The composition has the effects of reducing the activity of urease in gastric tissues and the content of NO and increasing the content of PGE in HP gastric ulcer mice.
Hericium erinaceus is not only a precious edible product but also an important medicinal fungus in China. Hericium erinaceus is one of eight Chinese "mountain delicacies", since ancient times, there is a saying that "mountain delicacies Hericium erinaceus, seafood bird's nest", and bear's paw, sea cucumber and shark's wing are listed as four famous vegetables, tender meat is delicious, delicious and tasty, nutritious, and the color, fragrance and taste are superior. In addition, the hericium erinaceus is also a traditional Chinese precious traditional Chinese medicine and has the functions of nourishing, building body, promoting digestion and benefiting five internal organs. Modern researches show that the traditional Chinese medicine composition contains active ingredients such as polypeptide, polysaccharide, fat, protein and the like, and has certain curative effects on digestive tract tumors, gastric ulcer, duodenal ulcer, gastritis, abdominal distension and the like.
Inulin is contained in the protoplast of a cell in a colloidal form, is easily dissolved in hot water unlike starch, is precipitated from water by adding ethanol, and does not react with iodine. Inulin is also very easily hydrolyzed to fructose under dilute acid, which is characteristic of all fructans. Can also be hydrolyzed into fructose by inulase. Enzymes that break down inulin are lacking in both humans and animals. Inulin is a natural water-soluble dietary fiber, hardly hydrolyzed and digested by gastric acid, and is utilized only in the colon by beneficial microorganisms, thereby improving the intestinal environment. It has been found that the degree of proliferation of bifidobacteria depends on the number of primary bifidobacteria in the large intestine of humans, and that the effect of proliferation is significant when inulin is used when the number of primary bifidobacteria is reduced, and not significant when inulin is used when the number of primary bifidobacteria is increased. Secondly, after the inulin is ingested, the gastrointestinal peristalsis can be enhanced, the gastrointestinal function can be improved, the digestion and the appetite can be increased, and the organism immunity can be improved.
The arabinogalactan is neutral polysaccharide composed of arabinose and galactose. The sugar is contained in the xylem of conifers in large amounts, up to 25% in particular in larch, and can be extracted from wood flour with water. The content ratio of L-arabinose to D-galactose is generally 1: 5-6. Is a structure with many branches, and beta-1, 3-bond arabinose side chains are connected in beta-1, 3-bond or beta-1, 6-bond galactose chains. The dietary fiber not only has strong function of activating immune function, but also can directionally deliver nutrient substances, and is a good dietary fiber.
When the traditional medicine is used for treating the gastrointestinal diseases, not only are harmful bacteria in intestines and stomachs killed, but also beneficial bacteria are damaged, and the balance of the bacteria in the intestines and the stomachs is directly destroyed, which is the root cause of repeated attack of duodenal ulcer. If the antibiotic is taken for a long time, the human body can generate extremely stubborn 014 drug-resistant bacteria which harm other organs in the body. The invention aims to provide the hericium erinaceus and inulin composite beverage which is fine in taste and rich in nutrition, so that the problem is solved fundamentally, harmful bacteria in intestines and stomach are effectively killed, and beneficial bacteria are not damaged; eliminates harmful bacteria such as helicobacter pylori and escherichia coli from the source, and effectively prevents the deterioration of the duodenal ulcer.
The invention adopts the vibration membrane separation concentration process to treat the extracting solution, thereby realizing the effects of microfiltration, ultrafiltration and nanofiltration to remove impurities and concentrate, replacing the 'alcohol precipitation and impurity removal' and 'static membrane concentration' used in the processes of removing impurities and concentrating after the conventional hot water extraction, reducing the organic pollution of the environment and avoiding the problem that the extraction efficiency is influenced by the blockage of the static membrane.
The hericium erinaceus contains active ingredients such as polypeptide, polysaccharide, fat and protein, and the like, has ideal effect on repairing gastric mucosa, but the roots of the dried products need to be removed before processing and extraction because the bitter glycoside ingredients are generated at the roots of the dried products, so the taste is influenced, the extraction time is 8-40 minutes/time by adopting a 580Mpa-620Mpa normal-temperature ultrahigh-pressure extraction technology, the extraction process is repeated for 2-6 times, the bioactive ingredients can be effectively extracted, and simultaneously the bitter taste is greatly reduced.
The invention adopts an extraction process of extracting under the constant pressure of 580Mpa-620Mpa in a normal temperature and ultrahigh pressure extractor for 8-40 minutes/time and repeatedly extracting for 2-6 times, so that not only can bioactive substances in the materials be effectively extracted, but also aromatic substances can be effectively retained in an extracting solution.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (10)

1. A preparation method of natural composite powder for removing helicobacter pylori in vivo is characterized by comprising the following steps:
A. preparing clove, hericium erinaceus, poria cocos, kudzu vine root, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel, ginger, arabinogalactan, fructooligosaccharide, isomaltooligosaccharide, yeast beta-glucan, epigallocatechin gallate, cranberry fruit powder, bovine colostrum powder, lactoferrin, lactobacillus reuteri and dihydroquercetin;
B. preparing the mixed traditional Chinese medicine extract of clove, hericium erinaceus, poria cocos, radix puerariae, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried orange peel and ginger in equal parts by weight;
C. b, concentrating the traditional Chinese medicine extracting solution obtained in the step B;
D. c, spreading the traditional Chinese medicine extracting solution obtained in the step C into a freeze-drying chamber at the temperature of-80 ℃ for low-temperature drying;
E. d, crushing the dried substance obtained in the step D, and filtering the crushed substance through a 120-mesh sieve to obtain powder;
F. and E, mixing 1 part by weight of fructo-oligosaccharide, 0.8-1.2 parts by weight of yeast beta-glucan, 0.8-1.2 parts by weight of cranberry fruit powder, 0.8-1.2 parts by weight of bovine colostrum powder, 0.8-1.2 parts by weight of lactoferrin, 0.8-1.2 parts by weight of inulin, 0.8-1.2 parts by weight of isomaltooligosaccharide, 0.8-1.2 parts by weight of arabinogalactan, 0.08-0.12 parts by weight of dihydroquercetin, 0.08-0.12 parts by weight of lactobacillus reuteri and 0.08-0.12 parts by weight of epigallocatechin gallate to obtain the natural composite powder for removing helicobacter pylori in vivo.
2. The method for preparing natural composite powder for removing helicobacter pylori in vivo according to claim 1, wherein the step B comprises: selecting equal parts by weight of moldy and rotten-free, worm-eaten-free and dried clove, hericium erinaceus, poria cocos, radix puerariae, lotus root starch, glutinous rice flour, cassia bark, fennel, nutmeg, dried tangerine peel and dried ginger, cleaning and crushing, mixing crushed mixed materials 0.8-1.2 parts by weight with 18-22 parts by weight of water, putting the mixed materials into an extraction bottle, putting the extraction bottle into a normal-temperature ultrahigh-pressure extractor, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 min/time, pouring out traditional Chinese medicine extracting solution from the extraction bottle, adding 18-22 parts by weight of water into the extraction bottle again, mixing, putting the extraction bottle into the normal-temperature ultrahigh-pressure extractor, carrying out normal-temperature ultrahigh-pressure extraction at a constant pressure of 580MPa-620MPa for 8-40 min/time, taking out the extraction bottle, pouring out the traditional Chinese medicine extracting solution from the extraction bottle, repeating the extraction for 2-6 times, and filtering to obtain Chinese medicinal extractive solution.
3. The method for preparing natural composite powder for removing helicobacter pylori in vivo according to claim 2, wherein the step C comprises: and D, selecting membrane packages with different molecular weights of 20-500nm from the traditional Chinese medicine extract obtained in the step B, and concentrating by using a graded vibration membrane.
4. The method for preparing natural composite powder for removing helicobacter pylori from the body as claimed in claim 3, wherein step C is to select the membrane packages with different molecular weights of 20-100nm, 100-300nm and 450-500nm from the Chinese medicine extract obtained in step B and concentrate the Chinese medicine extract by using a graded vibrating membrane.
5. The method for preparing a natural composite powder for removing helicobacter pylori according to claim 4, wherein the step D comprises spreading the 19-21 parts by weight of the Chinese medicinal extract obtained in the step C in a freeze-drying chamber at-80 ℃ and drying at low temperature.
6. The method as claimed in claim 5, wherein the step E comprises collecting the dried powder obtained in step D, pulverizing the collected powder in a convection pulverizer, and sieving the pulverized powder with a 120-mesh sieve after 4000-9000 convection pulverization.
7. The method according to claim 6, wherein the step F comprises mixing the powder obtained in step E with 1 part by weight of fructo-oligosaccharide, 0.9-1.1 parts by weight of yeast β -glucan, 0.9-1.1 parts by weight of cranberry fruit powder, 0.9-1.1 parts by weight of bovine colostrum powder, 0.9-1.1 parts by weight of lactoferrin, 0.9-1.1 parts by weight of inulin, 0.9-1.1 parts by weight of isomaltooligosaccharide, 0.9-1.1 parts by weight of arabinogalactan, 0.09-0.11 parts by weight of dihydroquercetin, 0.09-0.11 parts by weight of Lactobacillus reuteri, and 0.09-0.11 parts by weight of epigallocatechin gallate to obtain the natural helicobacter pylori-containing composite powder.
8. A natural composite powder for removing helicobacter pylori in vivo is characterized by comprising: 0.8-1.2 parts of fructo-oligosaccharide, 0.8-1.2 parts of yeast beta-glucan, 0.8-1.2 parts of cranberry fruit powder, 0.8-1.2 parts of bovine colostrum powder, 0.8-1.2 parts of lactoferrin, 0.8-1.2 parts of inulin, 0.8-1.2 parts of isomaltooligosaccharide, 0.8-1.2 parts of arabinogalactan, 0.08-0.12 parts of dihydroquercetin, 0.08-0.12 parts of lactobacillus reuteri, 0.08-0.12 parts of epigallocatechin gallate and 1 part of mixed traditional Chinese medicine by weight, wherein the mixed traditional Chinese medicine comprises clove, hericium erinaceus, poria cocos, kudzu root, lotus root starch, sticky rice powder, common fennel, nutmeg, dried orange peel and ginger in equal parts by weight.
9. The natural composite powder for removing helicobacter pylori bacteria in vivo according to claim 8, comprising: 0.9-1.1 weight parts of fructo-oligosaccharide, 0.9-1.1 weight parts of yeast beta-glucan, 0.9-1.1 weight parts of cranberry fruit powder, 0.9-1.1 weight parts of bovine colostrum powder, 0.9-1.1 weight parts of lactoferrin, 0.9-1.1 weight parts of inulin, 0.9-1.1 weight parts of isomaltooligosaccharide, 0.9-1.1 weight parts of arabinogalactan, 0.09-0.11 weight parts of dihydroquercetin, 0.09-0.11 weight parts of lactobacillus reuteri, 0.09-0.11 weight parts of epigallocatechin gallate and 1 weight part of mixed traditional Chinese medicine, wherein the mixed traditional Chinese medicine comprises clove extract, hericium erinaceum extract, poria cocos extract, kudzu root extract, lotus root powder extract, glutinous rice flour extract, cinnamon extract, fennel extract, myristica nutmeg extract, dried orange peel extract and the same weight parts of mixed traditional Chinese medicine, Ginger extract.
10. The natural composite powder for removing helicobacter pylori bacteria in vivo according to claim 9, comprising: 1.0 part by weight of fructo-oligosaccharide, 1.0 part by weight of yeast beta-glucan, 1.0 part by weight of cranberry fruit powder, 1.0 part by weight of bovine colostrum powder, 1.0 part by weight of lactoferrin, 1.0 part by weight of inulin, 1.0 part by weight of isomaltooligosaccharide, 1.0 part by weight of arabinogalactan, 0.1 part by weight of dihydroquercetin, 0.1 part by weight of lactobacillus reuteri, and 0.1 part by weight of epigallocatechin gallate.
CN202210465121.8A 2022-04-29 2022-04-29 Natural composite powder for removing helicobacter pylori in vivo and preparation method thereof Withdrawn CN114938856A (en)

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Application publication date: 20220826