CN114938805A - Preparation method of organic-matter-resistant glutaraldehyde disinfectant - Google Patents

Preparation method of organic-matter-resistant glutaraldehyde disinfectant Download PDF

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CN114938805A
CN114938805A CN202210742348.2A CN202210742348A CN114938805A CN 114938805 A CN114938805 A CN 114938805A CN 202210742348 A CN202210742348 A CN 202210742348A CN 114938805 A CN114938805 A CN 114938805A
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glutaraldehyde
parts
resistant
organic
component
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徐宁宁
冷淑珍
郑庆禄
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Guangzhou High Step Chemical It Co ltd
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Guangzhou High Step Chemical It Co ltd
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/02Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/10Sulfones; Sulfoxides
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00Disinfectants; Antimicrobial compounds or mixtures thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D53/00Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34Chemical or biological purification of waste gases
    • B01D53/46Removing components of defined structure
    • B01D53/60Simultaneously removing sulfur oxides and nitrogen oxides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses an organic matter resistant glutaraldehyde disinfectant, which comprises the following raw materials in parts by weight: 5 parts of glutaraldehyde and 1 part of water-soluble organic compound; 1 part of osmotic component, 5 parts of deodorant and 200 parts of purified water; wherein the soluble organic compound is a multi-ether organic solvent, specifically one or more of diethylene glycol butyl ether, ethylene glycol monobutyl ether and dipropylene glycol methyl ether; the penetration component is preferably dimethyl sulfoxide, one or more organic compounds are added into the glutaraldehyde disinfectant product, so that organic matters attached to the surfaces of microorganisms are dissolved, and the glutaraldehyde disinfection component is promoted to contact with the microorganisms to achieve the effect of killing the microorganisms; meanwhile, a penetrating component is added to assist the sterilization component to contact with microorganisms, so that the sterilization effect is improved.

Description

Preparation method of organic-matter-resistant glutaraldehyde disinfectant
Technical Field
The invention relates to the technical field of livestock and poultry farm disinfection, and particularly relates to a preparation method of an organic matter-resistant glutaraldehyde disinfectant.
Background
With the continuous enlargement of the scale of livestock and poultry farms and the continuous improvement of the breeding density, the prevention and the treatment of virus diseases face great challenges, and how to prevent and treat the invasion of external viruses becomes the key point for preventing diseases. In order to ensure the health of livestock and poultry, the colony house must be disinfected regularly. Glutaraldehyde is widely applied to cleaning and disinfection of livestock and poultry breeding houses as an efficient disinfectant.
Organic matters such as excrement, urine, fat and blood exist in the livestock and poultry colony house, the organic matters can form a protective layer on the surface of microorganisms, the disinfectant is prevented from contacting the microorganisms, the microorganisms are protected mechanically, glutaraldehyde is easily affected by the organic matters during colony house disinfection, and the glutaraldehyde disinfection effect is reduced.
Disclosure of Invention
The invention aims to solve the problems of the background technology, and provides a preparation method and application of an organic-resistant glutaraldehyde disinfectant.
The purpose of the invention can be realized by the following technical scheme:
a preparation method of an organic-resistant glutaraldehyde disinfectant comprises the following steps:
putting purified water into a stirring kettle, sequentially adding glutaraldehyde, a water-soluble organic compound, a penetration component and a deodorant, slowly stirring at a constant speed for 30 minutes, and standing for 0.5 hour to obtain an organic matter-resistant glutaraldehyde disinfectant;
wherein the soluble organic compound is a multi-element ether organic solvent, and the multi-element ether organic solvent is one or more of diethylene glycol butyl ether, ethylene glycol monobutyl ether and dipropylene glycol methyl ether.
As a further technical scheme of the invention, the organic-resistant glutaraldehyde disinfectant comprises the following raw materials in parts by weight: 5-50 parts of glutaraldehyde and 1-25 parts of water-soluble organic compound; 1-10 parts of a penetrating component and 500 parts of purified water.
As a further technical scheme of the invention, the penetrating component is dimethyl sulfoxide.
As a further technical scheme of the invention, the organic-resistant glutaraldehyde disinfectant also comprises a deodorant, and the deodorant is zinc ricinoleate.
As a further technical scheme of the invention, the weight portion of the deodorant is 5-20.
An application of an organic-resistant glutaraldehyde disinfectant in livestock and poultry farms.
The invention has the beneficial effects that:
(1) the deodorant of zinc ricinoleate is a novel efficient and environment-friendly deodorant material, and has the characteristics of no toxicity, no smell, easy biodegradation and the like. It can be directly dissolved in water, and after dried, crystal residue is formed, and when it is contacted with water or moisture, the residual crystal can be reactivated; it has excellent ability to remove sulfur-containing compounds, and activated zinc atoms can form strong chemical bonds with nitrogen and sulfur atoms in odor to completely eliminate odor;
(2) the components are easy to obtain, the process conditions are simple and convenient, and the industrial production is easy to realize; the product achieves the purpose of dissolving organic matters in the culture environment by adding a water-soluble organic solvent and penetrating components, and improves the sterilization effect of glutaraldehyde in a high-organic-matter environment; the product has improved sterilization effect (organic resistance property) in organic matters: the product is added with water-soluble organic compounds which can dissolve organic matters attached to the surfaces of microorganisms and promote the contact of the glutaraldehyde disinfection components and the microorganisms to achieve the effect of killing the microorganisms; and (3) improving the permeability of the product: adding dimethyl sulfoxide penetrating component into the product to assist the sterilizing component to contact with microorganism; in addition, the component can react with the hydrophobic groups of the microbial protein to cause protein denaturation, and can act together with glutaraldehyde to pathogenic microorganisms to improve the sterilization effect of the product.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The invention relates to an organic matter resistant glutaraldehyde disinfectant, which comprises the following raw materials in parts by weight: 5 parts of glutaraldehyde and 1 part of a water-soluble organic compound; 1 part of osmotic component, 5 parts of deodorant and 200 parts of purified water;
wherein the soluble organic compound is a multi-ether organic solvent, specifically one or more of diethylene glycol butyl ether, ethylene glycol monobutyl ether and dipropylene glycol methyl ether; the osmotic component is preferably dimethyl sulfoxide; the deodorant is zinc ricinoleate.
Example 2
The invention relates to an organic-matter-resistant glutaraldehyde disinfectant, which comprises the following raw materials in parts by weight: 30 parts of glutaraldehyde and 15 parts of water-soluble organic compound; 6 parts of osmotic component, 12 parts of deodorant and 350 parts of purified water;
wherein the soluble organic compound is a multi-ether organic solvent, specifically one or more of diethylene glycol butyl ether, ethylene glycol monobutyl ether and dipropylene glycol methyl ether; the osmotic component is preferably dimethyl sulfoxide; the deodorant is zinc ricinoleate.
Example 3
The invention relates to an organic matter resistant glutaraldehyde disinfectant, which comprises the following raw materials in parts by weight: 50 parts of glutaraldehyde and 25 parts of water-soluble organic compound; 10 parts of a penetrating component, 20 parts of a deodorant and 500 parts of purified water;
wherein the soluble organic compound is a multi-element ether organic solvent, specifically one or more of diethylene glycol butyl ether, ethylene glycol monobutyl ether and dipropylene glycol methyl ether; the osmotic component is preferably dimethyl sulfoxide; the deodorant is zinc ricinoleate.
Example 4
A preparation method of an organic-resistant glutaraldehyde disinfectant comprises the following steps: the method comprises the following steps:
and (3) putting 200 parts of purified water into a stirring kettle, sequentially adding 5 parts of glutaraldehyde, 1 part of water-soluble organic compound, 1 part of osmotic component and 5 parts of deodorant, slowly stirring at a constant speed for 30 minutes, and standing for 0.5 hour to obtain the organic matter-resistant glutaraldehyde disinfectant.
Example 5
A preparation method of an organic-resistant glutaraldehyde disinfectant comprises the following steps: the method comprises the following steps:
and (2) putting 350 parts of purified water into a stirring kettle, sequentially adding 30 parts of glutaraldehyde, 15 parts of water-soluble organic compound, 6 parts of osmotic component and 12 parts of deodorant, slowly stirring at a constant speed for 30 minutes, and standing for 0.5 hour to obtain the organic matter-resistant glutaraldehyde disinfectant.
Example 6
A preparation method of an organic-resistant glutaraldehyde disinfectant comprises the following steps: the method comprises the following steps:
and (3) putting 500 parts of purified water into a stirring kettle, sequentially adding 50 parts of glutaraldehyde, 25 parts of water-soluble organic compound, 10 parts of osmotic component and 20 parts of deodorant, slowly stirring at a constant speed for 30 minutes, and standing for 0.5 hour to obtain the organic matter-resistant glutaraldehyde disinfectant.
Example 7
An organic matter-resistant glutaraldehyde disinfectant is applied to livestock and poultry farms.
Comparative example 1
The comparative example is a commercial glutaraldehyde disinfectant product.
The experimental method comprises the following steps: the samples of example 1 and comparative example 1 were diluted by 500 times and 800 times, and the two dilutions were allowed to act on the E.coli bacterial solution for 5min, and the sterilization rates of the two products were calculated as follows:
Figure BDA0003715718310000041
from the above table, it can be seen that: the two samples are diluted by 500 and 800 times, the escherichia coli liquid acts for 5min, and the sterilization rate of the experimental group sample is obviously higher than that of the control group sample. Mainly because dimethyl sulfoxide with a permeation function is added into a product of a control group, and the component can react with a hydrophobic group of microbial protein to cause protein denaturation, and the protein denaturation and the pathogenic microorganism can act together with glutaraldehyde to improve the sterilization effect of the product.
Comparative example 2
Comparative example 2 is a commercially available glutaraldehyde disinfectant product.
The experimental method comprises the following steps: both example 1 and comparative example 2 samples were diluted 300-fold and 500-fold and E.coli suspensions were prepared using 5% fetal bovine serum (FBS, using FBS as the organic interfering substance). And (3) reacting the two dilutions with an escherichia coli bacterial suspension with organic matter interference for 5min, and calculating the sterilization rates of the two products, wherein the results are as follows:
Figure BDA0003715718310000051
conclusion description: under the interference of organic matters, the two samples are diluted by 300 times and 500 times, the Escherichia coli bacterial suspension is acted for 5min, and the sterilization rate of the experimental group sample is obviously higher than that of the control group sample. Mainly because the water-soluble organic component is added into the product of the control group, the component can dissolve the organic matter attached to the surface of the microorganism and promote the contact of the glutaraldehyde disinfection component and the microorganism to achieve the effect of killing the microorganism.
Although one embodiment of the present invention has been described in detail, the description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the scope of the invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.

Claims (6)

1. The preparation method of the organic-resistant glutaraldehyde disinfectant is characterized by comprising the following steps:
putting purified water into a stirring kettle, sequentially adding glutaraldehyde, a water-soluble organic compound, a penetration component and a deodorant, slowly stirring at a constant speed for 30 minutes, and standing for 0.5 hour to obtain an organic matter-resistant glutaraldehyde disinfectant;
wherein the soluble organic compound is a multi-element ether organic solvent, and the multi-element ether organic solvent is one or more of diethylene glycol butyl ether, ethylene glycol monobutyl ether and dipropylene glycol methyl ether.
2. The method for preparing the organic matter-resistant glutaraldehyde disinfectant according to claim 1, wherein the organic matter-resistant glutaraldehyde disinfectant comprises the following raw materials in parts by weight: 5-50 parts of glutaraldehyde and 1-25 parts of water-soluble organic compound; 1-10 parts of a penetrating component and 500 parts of purified water.
3. The method of claim 2 wherein the penetrating component is dimethyl sulfoxide.
4. The method for preparing an organic matter resistant glutaraldehyde disinfectant according to claim 3, wherein the organic matter resistant glutaraldehyde disinfectant further comprises a deodorant, and the deodorant is zinc ricinoleate.
5. The method for preparing an organic matter resistant glutaraldehyde disinfectant as recited in claim 4, wherein the deodorant is 5-20 parts by weight.
6. Use of an organic-resistant glutaraldehyde disinfectant prepared by the method of claim 1 in livestock and poultry farms.
CN202210742348.2A 2022-06-27 2022-06-27 Preparation method of organic-matter-resistant glutaraldehyde disinfectant Pending CN114938805A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3708263A (en) * 1971-01-15 1973-01-02 Wave Energy Systems Method for continuous sterilization at low temperature
GB8724830D0 (en) * 1987-10-23 1987-11-25 Microbiologicals Ltd Disinfectant composition
CN101579330A (en) * 2009-06-25 2009-11-18 中国农业大学 Disinfectant for animals and preparation method thereof
CN105494339A (en) * 2016-02-02 2016-04-20 成都科宏达科技有限公司 Disinfectant for disinfection of livestock and poultry farms, as well as application thereof
CN108159865A (en) * 2017-12-20 2018-06-15 苏州禾川化学技术服务有限公司 A kind of environment-friendly deodorant agent containing active zinc atom
CN110934137A (en) * 2018-09-21 2020-03-31 上海利康消毒高科技有限公司 Composite glutaraldehyde disinfectant and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3708263A (en) * 1971-01-15 1973-01-02 Wave Energy Systems Method for continuous sterilization at low temperature
GB8724830D0 (en) * 1987-10-23 1987-11-25 Microbiologicals Ltd Disinfectant composition
CN101579330A (en) * 2009-06-25 2009-11-18 中国农业大学 Disinfectant for animals and preparation method thereof
CN105494339A (en) * 2016-02-02 2016-04-20 成都科宏达科技有限公司 Disinfectant for disinfection of livestock and poultry farms, as well as application thereof
CN108159865A (en) * 2017-12-20 2018-06-15 苏州禾川化学技术服务有限公司 A kind of environment-friendly deodorant agent containing active zinc atom
CN110934137A (en) * 2018-09-21 2020-03-31 上海利康消毒高科技有限公司 Composite glutaraldehyde disinfectant and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张先亮 等编著: "精细化学品化学", 30 September 2021, pages: 36 *

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