CN114931621A - Preparation method of medicine for treating seborrheic alopecia - Google Patents
Preparation method of medicine for treating seborrheic alopecia Download PDFInfo
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- CN114931621A CN114931621A CN202210648719.0A CN202210648719A CN114931621A CN 114931621 A CN114931621 A CN 114931621A CN 202210648719 A CN202210648719 A CN 202210648719A CN 114931621 A CN114931621 A CN 114931621A
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- 239000003814 drug Substances 0.000 title claims abstract description 42
- 201000004384 Alopecia Diseases 0.000 title claims abstract description 39
- 231100000360 alopecia Toxicity 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
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- 239000002775 capsule Substances 0.000 claims abstract description 18
- 239000007921 spray Substances 0.000 claims abstract description 18
- 238000005507 spraying Methods 0.000 claims abstract description 7
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- 241000258920 Chilopoda Species 0.000 claims description 18
- 241000931705 Cicada Species 0.000 claims description 18
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- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 18
- 235000017443 Hedysarum boreale Nutrition 0.000 claims description 18
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- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 18
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- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 15
- 241001180876 Saposhnikovia Species 0.000 claims description 14
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 claims description 13
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
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- 230000000694 effects Effects 0.000 abstract description 17
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- 201000010099 disease Diseases 0.000 description 5
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- 210000004209 hair Anatomy 0.000 description 4
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- 239000000463 material Substances 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 2
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- 230000002159 abnormal effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000003779 hair growth Effects 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- YOBAEOGBNPPUQV-UHFFFAOYSA-N iron;trihydrate Chemical compound O.O.O.[Fe].[Fe] YOBAEOGBNPPUQV-UHFFFAOYSA-N 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
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Classifications
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Abstract
The invention discloses a preparation method of a medicine for treating seborrheic alopecia, which is characterized in that ginger and Chinese honeylocust fruit juice spray and capsules are respectively prepared, wherein the spray comprises the following raw materials: ginger and Chinese honeylocust fruit; the capsule comprises the following raw materials: radix rehmanniae Preparata, Haematitum, Polygoni Multiflori radix (preparata), radix Angelicae sinensis, radix Codonopsis, fructus Psoraleae, Kochiae fructus, cortex Dictamni Radicis, cortex moutan, herba Epimedii, radix Glycyrrhizae Preparata, rhizoma Ligustici Chuanxiong, periostracum Cicadae, radix Sophorae Flavescentis, radix Saposhnikoviae, herba Schizonepetae, Bombyx Batryticatus (parched with bran), and Scolopendra. The ginger and Chinese honeylocust fruit juice spray and the capsule are used together in a mode of external spraying and internal administration, are mainly used for treating symptoms such as seborrheic alopecia and scalp pruritus, have the effects of nourishing yin, nourishing blood, dispelling wind, relieving itching, removing grease and the like, have good treatment effect and are not easy to relapse.
Description
The application is a divisional application with the application date of 2020, 01, 15 and the application number of 202010043214.2, and the invention is named as 'a medicament for treating seborrheic alopecia and a preparation method thereof'.
Technical Field
The invention relates to the field of medicines, in particular to a preparation method of a medicine for treating seborrheic alopecia.
Background
Seborrheic alopecia is common in men, brainworkers are more than physical workers, people engaged in nervous and complex brainwork have high mental stress and large brain consumption energy, and in order to maintain physiological balance, more male hormones are secreted, and sebaceous glands are exuberant in secretion. The sebaceous glands on the scalp are more developed compared with other parts, and in such a case, secretion is more, so that conditions are provided for mass propagation of lipophilicity fungi, head mites and the like on the scalp, mass propagation is obtained, the disaster lipophilicity fungi obtain nutrition from hair follicles and discharge metabolites in the hair follicles, the hair follicles and the scalp are stimulated to generate chronic seborrheic dermatitis, if the seborrheic dermatitis cannot be treated in time, rhizosphere bacteria grow and propagate to generate a lytic enzyme, so that incomplete hair roots are formed, the hair roots are loosened, the hair follicles are gradually shrunken, the hair growing function is gradually reduced, and the hair is gradually reduced until alopecia.
Most of the currently applied medicaments for treating seborrheic alopecia are expensive and have limited treatment effect, and after long-term administration of the medicaments, the treatment effect is not ideal, and the medicaments are easy to relapse, thereby bringing heavy hit to the spirit of alopecia patients.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a preparation method of a medicine for treating seborrheic alopecia, the prepared medicine is used for symptoms such as seborrheic alopecia and scalp pruritus, has the effects of nourishing yin, nourishing blood, dispelling wind, relieving itching, removing grease and the like, and has good treatment effect, the total effective rate of a patient is 100 percent at most after 30 days of treatment, the patient is not easy to relapse, and the relapse rate of the patient in 3 months is 10 percent at most.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides a medicine for treating seborrheic alopecia, which comprises the following raw materials in parts by weight: 400 parts of ginger 200-ion materials, 200 parts of Chinese honeylocust fruit 100-ion materials, 50-150 parts of prepared rehmannia root, 45-85 parts of red ochre, 45-85 parts of prepared fleece-flower root, 45-85 parts of Chinese angelica, 45-85 parts of pilose asiabell root, 45-85 parts of malaytea scurfpea fruit, 45-85 parts of belvedere fruit, 45-85 parts of dittany bark, 30-60 parts of tree peony bark, 30-60 parts of epimedium herb, 30-60 parts of honey-fried licorice root, 30-60 parts of szechuan lovage rhizome, 30-60 parts of cicada slough, 30-60 parts of lightyellow sophora root, 30-60 parts of divaricate saposhnikovia root, 30-60 parts of fineleaf schizonepeta herb, 30-60 parts of stiff silkworm (stir-fried with bran) and 2-3 parts of centipede.
Preferably, the feed comprises the following raw materials in parts by weight: 300 parts of ginger, 150 parts of Chinese honeylocust fruit, 100 parts of prepared rehmannia root, 65 parts of ruddle, 65 parts of fleece-flower root (prepared), 65 parts of Chinese angelica, 65 parts of pilose asiabell root, 65 parts of malaytea scurfpea fruit, 65 parts of broom cypress fruit, 65 parts of dittany bark, 45 parts of tree peony bark, 45 parts of epimedium herb, 45 parts of honey-fried licorice root, 45 parts of szechuan lovage rhizome, 45 parts of cicada slough, 45 parts of lightyellow sophora root, 45 parts of divaricate saposhnikovia root, 45 parts of fineleaf schizonepeta herb, 45 parts of stiff silkworm (stir-fried with bran) and 2.5 parts of centipede.
Preferably, the feed comprises the following raw materials in parts by weight: 250 parts of ginger, 125 parts of Chinese honeylocust fruit, 75 parts of prepared rehmannia root, 50 parts of ruddle, 50 parts of fleece-flower root (prepared), 50 parts of Chinese angelica, 50 parts of pilose asiabell root, 50 parts of malaytea scurfpea fruit, 50 parts of broom cypress fruit, 50 parts of dittany bark, 35 parts of tree peony bark, 35 parts of epimedium herb, 35 parts of honey-fried licorice root, 35 parts of szechuan lovage rhizome, 35 parts of cicada slough, 35 parts of lightyellow sophora root, 35 parts of divaricate saposhnikovia root, 35 parts of fineleaf schizonepeta herb, 35 parts of stiff silkworm (stir-fried with bran) and 2.2 parts of centipede.
Preferably, the feed comprises the following raw materials in parts by weight: 350 parts of ginger, 175 parts of Chinese honeylocust fruit, 125 parts of prepared rehmannia root, 80 parts of ruddle, 80 parts of fleece-flower root (prepared), 80 parts of Chinese angelica, 80 parts of pilose asiabell root, 80 parts of malaytea scurfpea fruit, 80 parts of broom cypress fruit, 80 parts of dittany bark, 50 parts of tree peony bark, 50 parts of epimedium herb, 50 parts of honey-fried licorice root, 50 parts of szechuan lovage rhizome, 50 parts of cicada slough, 50 parts of lightyellow sophora root, 50 parts of divaricate saposhnikovia root, 50 parts of fineleaf schizonepeta herb, 50 parts of stiff silkworm (stir-fried with bran) and 2.8 parts of centipede.
Preferably, the feed comprises the following raw materials in parts by weight: 200 parts of ginger, 100 parts of Chinese honeylocust fruit, 50 parts of prepared rehmannia root, 45 parts of ruddle, 45 parts of fleece-flower root (prepared), 45 parts of Chinese angelica, 45 parts of pilose asiabell root, 45 parts of malaytea scurfpea fruit, 45 parts of broom cypress fruit, 45 parts of dittany bark, 30 parts of tree peony bark, 30 parts of epimedium herb, 30 parts of honey-fried licorice root, 30 parts of szechuan lovage rhizome, 30 parts of cicada slough, 30 parts of lightyellow sophora root, 30 parts of divaricate saposhnikovia root, 30 parts of fineleaf schizonepeta herb, 30 parts of stiff silkworm (stir-fried with bran) and 2 parts of centipede.
Preferably, the feed comprises the following raw materials in parts by weight: 400 parts of ginger, 200 parts of Chinese honeylocust fruit, 150 parts of prepared rehmannia root, 85 parts of ruddle, 85 parts of fleece-flower root (prepared), 85 parts of Chinese angelica, 85 parts of pilose asiabell root, 85 parts of malaytea scurfpea fruit, 85 parts of broom cypress fruit, 85 parts of dittany bark, 60 parts of tree peony bark, 60 parts of epimedium herb, 60 parts of honey-fried licorice root, 60 parts of szechuan lovage rhizome, 60 parts of cicada slough, 60 parts of lightyellow sophora root, 60 parts of divaricate saposhnikovia root, 60 parts of fineleaf schizonepeta herb, 60 parts of stiff silkworm (stir-fried with bran) and 3 parts of centipede.
The invention also provides a preparation method of the medicine for treating seborrheic alopecia, and the technical scheme is as follows:
a preparation method of a medicine for treating seborrheic alopecia comprises the following steps:
squeezing rhizoma Zingiberis recens;
soaking fructus Gleditsiae Abnormalis in equal amount of 85% ethanol at 65 deg.C for 12 hr, adding the pressed rhizoma Zingiberis recens juice, and filtering to obtain rhizoma Zingiberis recens fructus Gleditsiae Abnormalis juice spray;
pulverizing Haematitum, radix Polygoni Multiflori Preparata, radix Angelicae sinensis, cortex moutan, rhizoma Ligustici Chuanxiong and Scolopendra into crude drug powder;
decocting radix rehmanniae Preparata, radix Codonopsis, fructus Psoraleae, Kochiae fructus, cortex Dictamni Radicis, herba Epimedii, radix Glycyrrhizae Preparata, periostracum Cicadae, radix Sophorae Flavescentis, radix Saposhnikoviae, herba Schizonepetae and Bombyx Batryticatus with 10 times and 8 times of water for 3 hr twice, mixing decoctions, and filtering;
concentrating the above filtrate to obtain soft extract with relative density of 1.30-1.35(60 deg.C), mixing with the obtained crude drug powder, drying, pulverizing, adding microcrystalline cellulose, granulating, adding magnesium stearate, mixing, and making into capsule.
Preferably, the prepared ginger and saponin juice spray and capsule are used in combination in an external spraying and internal administration mode.
The medicine for treating seborrheic alopecia has the beneficial effects that the medicine is suitable for symptoms such as seborrheic alopecia and scalp pruritus, has the effects of nourishing yin, nourishing blood, dispelling wind, relieving itching, removing grease and the like, and is good in treatment effect, not easy to relapse and low in cost.
Detailed Description
The following provides a detailed description of embodiments of the invention.
Example 1:
a medicine for treating seborrheic alopecia comprises the following raw materials in parts by weight: 400 parts of ginger 200-ion materials, 200 parts of Chinese honeylocust fruit 100-ion materials, 50-150 parts of prepared rehmannia root, 45-85 parts of red ochre, 45-85 parts of prepared fleece-flower root, 45-85 parts of Chinese angelica, 45-85 parts of pilose asiabell root, 45-85 parts of malaytea scurfpea fruit, 45-85 parts of belvedere fruit, 45-85 parts of dittany bark, 30-60 parts of tree peony bark, 30-60 parts of epimedium herb, 30-60 parts of honey-fried licorice root, 30-60 parts of szechuan lovage rhizome, 30-60 parts of cicada slough, 30-60 parts of lightyellow sophora root, 30-60 parts of divaricate saposhnikovia root, 30-60 parts of fineleaf schizonepeta herb, 30-60 parts of stiff silkworm (stir-fried with bran) and 2-3 parts of centipede.
The preparation method of the medicine for treating seborrheic alopecia comprises the following steps:
squeezing rhizoma Zingiberis recens to obtain juice;
soaking fructus Gleditsiae Abnormalis in equal amount of 85% ethanol at 65 deg.C for 12 hr, adding the pressed rhizoma Zingiberis recens juice, and filtering to obtain rhizoma Zingiberis recens fructus Gleditsiae Abnormalis juice spray;
pulverizing Haematitum, radix Polygoni Multiflori Preparata, radix Angelicae sinensis, cortex moutan, rhizoma Ligustici Chuanxiong and Scolopendra into crude drug powder;
decocting radix rehmanniae Preparata, radix Codonopsis, fructus Psoraleae, Kochiae fructus, cortex Dictamni Radicis, herba Epimedii, radix Glycyrrhizae Preparata, periostracum Cicadae, radix Sophorae Flavescentis, radix Saposhnikoviae, herba Schizonepetae and Bombyx Batryticatus with 10 times and 8 times of water for 3 hr twice, mixing decoctions, and filtering;
concentrating the filtrate to obtain soft extract with relative density of 1.30-1.35(60 deg.C), mixing with the obtained crude drug powder, drying, pulverizing, adding 25 parts of microcrystalline cellulose, granulating, adding 1 part of magnesium stearate, mixing, and making into capsule.
The medication method comprises the following steps: spraying the decoction onto scalp for oral administration, spraying ginger and fructus Gleditsiae Abnormalis juice spray onto clean and dry scalp surface, 2-3ml each time, 3 times a day; the capsule is orally administered 6-8 granules at a time, 3 times a day.
Example 2:
a medicine for treating seborrheic alopecia comprises the following raw materials in parts by weight: 300 parts of ginger, 150 parts of Chinese honeylocust fruit, 100 parts of prepared rehmannia root, 65 parts of ruddle, 65 parts of fleece-flower root (prepared), 65 parts of Chinese angelica, 65 parts of pilose asiabell root, 65 parts of malaytea scurfpea fruit, 65 parts of broom cypress fruit, 65 parts of dittany bark, 45 parts of tree peony bark, 45 parts of epimedium herb, 45 parts of honey-fried licorice root, 45 parts of szechuan lovage rhizome, 45 parts of cicada slough, 45 parts of lightyellow sophora root, 45 parts of divaricate saposhnikovia root, 45 parts of fineleaf schizonepeta herb, 45 parts of stiff silkworm (stir-fried with bran) and 2.5 parts of centipede.
The preparation method of the medicine for treating seborrheic alopecia of the embodiment 2 is the same as that of the embodiment 1.
Example 3:
a medicine for treating seborrheic alopecia comprises the following raw materials in parts by weight: 250 parts of ginger, 125 parts of Chinese honeylocust fruit, 75 parts of prepared rehmannia root, 50 parts of ruddle, 50 parts of fleece-flower root (prepared), 50 parts of Chinese angelica, 50 parts of pilose asiabell root, 50 parts of malaytea scurfpea fruit, 50 parts of broom cypress fruit, 50 parts of dittany bark, 35 parts of tree peony bark, 35 parts of epimedium herb, 35 parts of honey-fried licorice root, 35 parts of szechuan lovage rhizome, 35 parts of cicada slough, 35 parts of lightyellow sophora root, 35 parts of divaricate saposhnikovia root, 35 parts of fineleaf schizonepeta herb, 35 parts of stiff silkworm (stir-fried with bran) and 2.2 parts of centipede.
The preparation method of the medicine for treating seborrheic alopecia of the embodiment 3 is the same as that of the embodiment 1.
Example 4:
a medicine for treating seborrheic alopecia comprises the following raw materials in parts by weight: 350 parts of ginger, 175 parts of Chinese honeylocust fruit, 125 parts of prepared rehmannia root, 80 parts of ruddle, 80 parts of fleece-flower root (prepared), 80 parts of Chinese angelica, 80 parts of pilose asiabell root, 80 parts of malaytea scurfpea fruit, 80 parts of broom cypress fruit, 80 parts of dittany bark, 50 parts of tree peony bark, 50 parts of epimedium herb, 50 parts of honey-fried licorice root, 50 parts of szechuan lovage rhizome, 50 parts of cicada slough, 50 parts of lightyellow sophora root, 50 parts of divaricate saposhnikovia root, 50 parts of fineleaf schizonepeta herb, 50 parts of stiff silkworm (stir-fried with bran) and 2.8 parts of centipede.
The preparation method of the medicine for treating seborrheic alopecia of the embodiment 4 is the same as that of the embodiment 1.
Example 5:
a medicine for treating seborrheic alopecia comprises the following raw materials in parts by weight: 200 parts of ginger, 100 parts of Chinese honeylocust fruit, 50 parts of prepared rehmannia root, 45 parts of ruddle, 45 parts of fleece-flower root (prepared), 45 parts of Chinese angelica, 45 parts of pilose asiabell root, 45 parts of malaytea scurfpea fruit, 45 parts of broom cypress fruit, 45 parts of dittany bark, 30 parts of tree peony bark, 30 parts of epimedium herb, 30 parts of honey-fried licorice root, 30 parts of szechuan lovage rhizome, 30 parts of cicada slough, 30 parts of lightyellow sophora root, 30 parts of divaricate saposhnikovia root, 30 parts of fineleaf schizonepeta herb, 30 parts of stiff silkworm (stir-fried with bran) and 2 parts of centipede.
The preparation method of the medicine for treating seborrheic alopecia of the embodiment 5 is the same as that of the embodiment 1.
Example 6:
a medicine for treating seborrheic alopecia comprises the following raw materials in parts by weight: 400 parts of ginger, 200 parts of Chinese honeylocust fruit, 150 parts of prepared rehmannia root, 85 parts of ruddle, 85 parts of fleece-flower root (prepared), 85 parts of Chinese angelica, 85 parts of pilose asiabell root, 85 parts of malaytea scurfpea fruit, 85 parts of broom cypress fruit, 85 parts of dittany bark, 60 parts of tree peony bark, 60 parts of epimedium herb, 60 parts of honey-fried licorice root, 60 parts of szechuan lovage rhizome, 60 parts of cicada slough, 60 parts of lightyellow sophora root, 60 parts of divaricate saposhnikovia root, 60 parts of fineleaf schizonepeta herb, 60 parts of stiff silkworm (stir-fried with bran) and 3 parts of centipede.
The preparation method of the medicine for treating seborrheic alopecia of this example 6 is the same as that of example 1.
The clinical trials for the above examples 2-6 were as follows:
1. case selection and grouping
200 patients with alopecia were randomized into 5 groups: examples 2-6 groups of 40 each.
No statistical difference exists among the age, sex, disease course and alopecia symptom severity degree of each group (p is greater than 0.05).
2. Inclusion criteria
(1) Age 18-65 years old;
(2) the clinical diagnosis standard of the alopecia is met;
(3) no other treatment is carried out within 1 month before the test;
(4) and no other serious organ diseases.
3. Exclusion criteria
(1) Alopecia due to developmental defects and genetic factors;
(2) alopecia caused by systemic diseases and the systemic diseases are not cured;
(3) pregnant or lactating women;
(4) those who have a history of allergy or allergic constitution to the pharmaceutical composition;
(5) patients with serious primary diseases such as cardiovascular diseases, liver diseases, kidney diseases or hemopoietic diseases;
(6) and patients with mental diseases.
4. Method of treatment
Spraying the decoction onto scalp for oral administration, spraying ginger and fructus Gleditsiae Abnormalis juice spray onto clean and dry scalp surface, 2-3ml each time, 3 times a day; the capsule is orally administered 6-8 granules at one time, 3 times a day, and 30 days as 1 course of treatment.
5. Observation index and therapeutic effect judgment standard
The clinical indexes are as follows: clinical symptoms and sign changes are observed day by day during the test period, and the occurrence time, the expression, the degree, the treatment and the results of various adverse reactions are closely monitored.
Laboratory indexes are as follows: before the test and after stopping the drug, the routine examination of blood, urine and stool, and the function of liver and kidney.
And (3) evaluating and grading the curative effect:
the overall improvement degree according to clinical symptoms and physical signs is divided into four grades:
and (3) healing: the clinical symptoms disappear, the hair growth returns to normal, and no abnormal or excessive shedding phenomenon exists;
the effect is shown: the clinical symptoms are obviously improved, the hair growth is basically normal, and the abnormal or excessive shedding phenomenon is not obvious;
the method has the following advantages: the clinical symptoms are improved, but the normal state is not recovered;
and (4) invalidation: the clinical symptoms are not improved or aggravated.
Observation of recurrence rate: after the administration, the patients with recovery, obvious effect and effective cases follow up for 3 months, and the disease recurrence rate is recorded.
6. Therapeutic results
After each test group is treated for 30 days and followed for 3 months, the clinical curative effect and recurrence rate statistics are shown in the following table 1:
TABLE 1 clinical efficacy and relapse Rate in each experimental group after application of the drugs of examples 2-6
| Group of | Number of examples | Recovery method | Show effect | Is effective | Nullification | Total effective rate | Recurrence rate |
| Example 2 | 40 | 22 | 17 | 1 | 0 | 100％ | 5％ |
| Example 3 | 40 | 14 | 20 | 2 | 4 | 90％ | 10％ |
| Example 4 | 40 | 18 | 15 | 4 | 3 | 92.5％ | 10％ |
| Example 5 | 40 | 20 | 17 | 2 | 1 | 97.5％ | 5％ |
| Example 6 | 40 | 16 | 19 | 3 | 2 | 95％ | 7.5％ |
According to the results in table 1, the total effective rate of the medicine for treating seborrheic alopecia prepared by the preparation method disclosed by the invention is up to 100% after 30 days of treatment, the clinical effect is good, the recurrence rate is low after 3 months of follow-up visit, and the recurrence rate is up to 10% after 3 months of follow-up visit. The medicine for treating seborrheic alopecia prepared by the preparation method has good effect. Clinical tests prove that: has obvious effect on treating symptoms such as seborrheic alopecia, scalp pruritus and the like, has the effects of nourishing yin, nourishing blood, dispelling wind, relieving itching, removing grease and the like, has good treatment effect and is not easy to relapse. Thus proving that the medicine is a safe and effective Chinese medicine preparation for treating seborrheic alopecia.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for the person skilled in the art, without departing from the inventive concept, several variations and modifications can be made, which fall within the scope of the invention.
Claims (4)
1. The preparation method of a medicament for treating seborrheic alopecia is characterized by comprising a preparation method of a spray and a preparation method of a capsule;
the preparation method of the spray comprises the following steps:
squeezing rhizoma Zingiberis recens;
soaking fructus Gleditsiae Abnormalis in equal amount of 85% ethanol at 65 deg.C for 12 hr, adding the pressed rhizoma Zingiberis recens juice, and filtering to obtain rhizoma Zingiberis recens fructus Gleditsiae Abnormalis juice spray;
the preparation method of the capsule comprises the following steps:
pulverizing Haematitum, Polygoni Multiflori radix, radix Angelicae sinensis, cortex moutan, rhizoma Ligustici Chuanxiong and Scolopendra into crude drug powder;
decocting twelve medicines of radix rehmanniae Preparata, radix Codonopsis, fructus Psoraleae, Kochiae fructus, cortex Dictamni Radicis, herba Epimedii, radix Glycyrrhizae Preparata, periostracum Cicadae, radix Sophorae Flavescentis, radix Saposhnikoviae, herba Schizonepetae and Bombyx Batryticatus with 10 times and 8 times of water for 3 hr twice, mixing decoctions, and filtering to obtain filtrate; concentrating the filtrate to obtain soft extract with relative density of 1.30-1.35; the temperature of the thick paste is 60 ℃;
mixing the above crude powder and soft extract, drying, pulverizing, adding microcrystalline cellulose, granulating, adding magnesium stearate, mixing, and making into capsule.
2. The preparation method according to claim 1, wherein the spray comprises the following raw materials in parts by weight: 200 portions of ginger and 200 portions of Chinese honeylocust fruit; the capsule comprises the following raw materials: 50-150 parts of prepared rehmannia root, 45-85 parts of ruddle, 45-85 parts of polygonum multiflorum (prepared), 45-85 parts of angelica, 45-85 parts of codonopsis pilosula, 45-85 parts of fructus psoraleae, 45-85 parts of fructus kochiae, 45-85 parts of cortex dictamni, 30-60 parts of moutan bark, 30-60 parts of epimedium, 30-60 parts of honey-fried licorice root, 30-60 parts of ligusticum wallichii, 30-60 parts of cicada slough, 30-60 parts of radix sophorae flavescentis, 30-60 parts of radix sileris, 30-60 parts of schizonepeta, 30-60 parts of stiff silkworm (stir-fried with bran) and 2-3 parts of centipede.
3. The preparation method of claim 1, wherein the spray comprises the following raw materials in parts by weight: 300 parts of ginger and 150 parts of Chinese honeylocust fruit; the capsule comprises the following raw materials in parts by weight: 100 parts of prepared rehmannia root, 65 parts of ruddle, 65 parts of polygonum multiflorum (prepared), 65 parts of angelica, 65 parts of codonopsis pilosula, 65 parts of fructus psoraleae, 65 parts of fructus kochiae, 65 parts of cortex dictamni, 45 parts of cortex moutan radicis, 45 parts of epimedium, 45 parts of honey-fried licorice root, 45 parts of ligusticum wallichii, 45 parts of periostracum cicada, 45 parts of radix sophorae flavescentis, 45 parts of radix sileris, 45 parts of schizonepeta, 45 parts of stiff silkworm (stir-fried with bran) and 2.5 parts of centipede;
or
The spray comprises the following raw materials in parts by weight: 250 parts of ginger and 125 parts of Chinese honeylocust fruit; the capsule comprises the following raw materials: 75 parts of prepared rehmannia root, 50 parts of ruddle, 50 parts of fleece-flower root (prepared), 50 parts of Chinese angelica, 50 parts of codonopsis pilosula, 50 parts of fructus psoraleae, 50 parts of fructus kochiae, 50 parts of cortex dictamni, 35 parts of moutan bark, 35 parts of epimedium, 35 parts of honey-fried licorice root, 35 parts of ligusticum wallichii, 35 parts of periostracum cicada, 35 parts of radix sophorae flavescentis, 35 parts of divaricate saposhnikovia root, 35 parts of schizonepeta, 35 parts of stiff silkworm (stir-fried with bran) and 2.2 parts of centipede;
or
The spray comprises the following raw materials in parts by weight: 350 parts of ginger and 175 parts of Chinese honeylocust fruit; the capsule comprises the following raw materials: 125 parts of prepared rehmannia root, 80 parts of ruddle, 80 parts of polygonum multiflorum (prepared), 80 parts of angelica, 80 parts of codonopsis pilosula, 80 parts of fructus psoraleae, 80 parts of fructus kochiae, 80 parts of cortex dictamni, 50 parts of cortex moutan, 50 parts of herba epimedii, 50 parts of honey-fried licorice root, 50 parts of ligusticum wallichii, 50 parts of periostracum cicada, 50 parts of radix sophorae flavescentis, 50 parts of radix sileris, 50 parts of schizonepeta, 50 parts of stiff silkworm (stir-fried with bran) and 2.8 parts of centipede;
or
The spray comprises the following raw materials in parts by weight: 200 parts of ginger and 100 parts of Chinese honeylocust fruit; the capsule comprises the following raw materials: 50 parts of prepared rehmannia root, 45 parts of ruddle, 45 parts of fleece-flower root (prepared), 45 parts of Chinese angelica, 45 parts of codonopsis pilosula, 45 parts of fructus psoraleae, 45 parts of fructus kochiae, 45 parts of cortex dictamni, 30 parts of moutan bark, 30 parts of herba epimedii, 30 parts of honey-fried licorice root, 30 parts of ligusticum wallichii, 30 parts of periostracum cicada, 30 parts of radix sophorae flavescentis, 30 parts of radix sileris, 30 parts of schizonepeta, 30 parts of stiff silkworm (stir-fried with bran) and 2 parts of centipede;
or
The spray comprises the following raw materials in parts by weight: 400 parts of ginger and 200 parts of Chinese honeylocust fruit; the capsule comprises the following raw materials: 150 parts of prepared rehmannia root, 85 parts of ruddle, 85 parts of fleece-flower root (prepared), 85 parts of Chinese angelica, 85 parts of pilose asiabell root, 85 parts of malaytea scurfpea fruit, 85 parts of belvedere fruit, 85 parts of dittany bark, 60 parts of tree peony bark, 60 parts of epimedium, 60 parts of honey-fried licorice root, 60 parts of szechuan lovage rhizome, 60 parts of cicada slough, 60 parts of lightyellow sophora root, 60 parts of divaricate saposhnikovia root, 60 parts of fineleaf schizonepeta herb, 60 parts of stiff silkworm (stir-fried with bran) and 3 parts of centipede.
4. The method according to any one of claims 1 to 3, wherein the obtained ginger saponin juice spray and capsule are used in combination by external spraying and internal application.
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| CN1368238A (en) * | 2001-02-01 | 2002-09-11 | 杨孟君 | Nano medicine for reducing fat and growing hair and its preparing process |
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