CN114931524A

CN114931524A - Antibacterial tooth-protecting toothpaste

Info

Publication number: CN114931524A
Application number: CN202210566159.4A
Authority: CN
Inventors: 曾赛璐; 黄敏
Original assignee: Shenzhen Ximalong Technology Co ltd
Current assignee: Shenzhen Ximalong Technology Co ltd
Priority date: 2022-05-24
Filing date: 2022-05-24
Publication date: 2022-08-23

Abstract

The invention relates to the field of toothpaste, in particular to antibacterial tooth-protecting toothpaste. The components of the milk powder comprise, by weight, 0.5-8 parts of lactoferrin, 0.5-8 parts of allicin, 10-30 parts of wetting agent, 15-45 parts of friction agent, 0.5-8.5 parts of foaming agent, 0.4-1.6 parts of adhesive, 0.15-0.3 part of stabilizer, 0.2-0.8 part of sweetening agent, a proper amount of water and edible essence. The invention adds lactoferrin powder and allicin as effective components into toothpaste, has obvious improvement on dental plaque, gingival swelling and pain and oral peculiar smell, has obvious functions of diminishing inflammation, inhibiting bacteria and resisting allergy, can be used for preventing and treating stomatitis, gingivitis, stomatitis, oral ulcer and the like, reduces oral diseases, and has natural, safe and environment-friendly components.

Description

Antibacterial tooth-protecting toothpaste

Technical Field

The invention relates to the field of toothpaste, in particular to antibacterial tooth-protecting toothpaste.

Background

With the acceleration of life rhythm, the change of eating habits and poor eating structure, the incidence of oral diseases is higher and higher, wherein the oral diseases such as stomatitis, dental limosis, dental plaque, dentin hypersensitivity, halitosis and oral ulcer. Therefore, inhibition of pathogenic bacteria in the oral cavity is an important measure for preventing oral diseases.

The toothpaste is a common oral product and mainly used for cleaning teeth and oral cavity. With the increasing awareness of oral health, toothpaste intended for cleaning teeth has been far from satisfying the needs of consumers, and thus functional toothpaste having the effects of preventing and health-care of oral diseases has been gradually developed. Most oral care products with antibacterial effect in the current market are added with chemical synthetic components, which can threaten oral health to a certain extent. The Chinese herbal medicine extract has incomparable advantages of natural, environment-friendly and safe chemical synthetic medicines, and in addition to the green and natural advocation of people, the functional toothpaste taking the natural plant extract as the effective component gradually receives the favor of consumers and becomes the mainstream of the development of the toothpaste market.

Disclosure of Invention

Aiming at the problems in the background technology, provides the bacteriostatic tooth-protecting toothpaste. The invention adds lactoferrin powder and garlicin as effective components into toothpaste, has obvious improvement on dental plaque, gingival swelling and pain and oral peculiar smell, has obvious functions of diminishing inflammation, inhibiting bacteria and resisting allergy, can be used for preventing and treating stomatitis, gingivitis, stomatitis, oral ulcer and the like, and reduces oral diseases.

The invention provides a bacteriostatic tooth-protecting toothpaste, which comprises 0.5-8 parts of lactoferrin, 0.5-8 parts of allicin, 10-30 parts of wetting agent, 15-45 parts of rubbing agent, 0.5-8.5 parts of foaming agent, 0.4-1.6 parts of adhesive, 0.15-0.3 part of stabilizer, 0.2-0.8 part of sweetener, a proper amount of water and edible essence according to the weight ratio.

Preferably, the humectant includes, but is not limited to, one or more of propylene glycol, sorbitol, glycerin, glycerol, and polyethylene glycol.

Preferably, the abrasive includes, but is not limited to, one or more of calcium hydrogen phosphate, silica, calcium carbonate, aluminum hydroxide, heavy calcium carbonate and light calcium carbonate.

Preferably, the foaming agent includes, but is not limited to, one or more of sodium lauryl sulfate, sodium N-lauroyl sarcosinate and sodium methylcocoyltaurate.

Preferably, the binding agent includes but is not limited to one or more of sodium alginate, sodium carboxymethylcellulose, xanthan gum, hydroxyethyl cellulose, guar gum, acacia gum and carrageenan.

Preferably, the stabilizer is sodium pyrophosphate.

Preferably, the sweetening agent includes, but is not limited to, one or more of saccharin sodium, sucrose, xylitol, cyclamate, and aspartame.

Preferably, the sweetener is xylitol.

Preferably, the flavoring essence includes, but is not limited to, one or more of menthol, spearmint oil, lime oil, lemon oil, orange oil, clove oil, jasmine oil, cherry oil and peppermint oil.

Preferably, the edible essence is jasmine oil.

The invention also provides a preparation method of the antibacterial tooth-protecting toothpaste, which comprises the following steps:

s1, weighing lactoferrin, allicin, a wetting agent, a foaming agent and a stabilizing agent according to the weight ratio, dissolving the materials in water, mixing and heating the materials to make the prepared colloid into a uniform, semitransparent and sticky liquid state, and then placing the colloid to be used after the colloid is dissolved and expanded;

s2, cooling the colloid obtained in the step S1 to 50-90 ℃, sequentially adding a friction agent, an adhesive and a sweetening agent, and continuously stirring;

s3, cooling the colloid to below 45 ℃, adding other auxiliary agents, and stirring to prepare paste;

s4, grinding the paste, then carrying out vacuum degassing, standing and sterilizing to obtain the toothpaste.

Preferably, the water in S1 is one or both of purified water or deionized water.

Preferably, the water is deionized water.

Preferably, the ratio of the allicin to the lactoferrin is 2: 1; the mass ratio of the lactoferrin powder to the deionized water is 1: 5-20.

Preferably, the mass ratio of the lactoferrin powder to the deionized water is 1: 10.

Preferably, the mixing in S1 is performed in a blender; heating is carried out in an azeotropic boiler; heating to 75-100 deg.C, and standing for 0.5 hr or more.

Preferably, the standing time is l-2 h.

Preferably, the cooling in S2 is to 65-70 ℃; the rotating speed of the stirring is 300-400r/min, and the stirring time is more than 0.5 h.

Preferably, the stirring time is l-2h, and the rotating speed is 350-.

Preferably, the milling in S4 is performed by a mill in two passes, a first pass followed by storage and a second pass followed by vacuum degassing.

Preferably, the degassing is carried out until the degree of vacuum reaches-0.093 MPa or less.

Preferably, the standing time is 2-4 h.

Compared with the prior art, the invention has the following beneficial technical effects:

the invention adds lactoferrin powder and allicin as effective components into toothpaste, has obvious improvement on dental plaque, gingival swelling and pain and oral peculiar smell, has obvious functions of diminishing inflammation, inhibiting bacteria and resisting allergy, can be used for preventing and treating stomatitis, gingivitis, stomatitis, oral ulcer and the like, reduces oral diseases, and has natural, safe and environment-friendly components. In addition, the preparation process is simple, the operation is convenient and fast, and the public health value is obvious.

Detailed Description

Example 1

The invention provides antibacterial tooth-protecting toothpaste, which comprises 0.5 part of lactoferrin, 1 part of allicin, 20 parts of wetting agent, 20 parts of rubbing agent, 1.2 parts of foaming agent, 1 part of adhesive, 0.2 part of stabilizer, 0.5 part of sweetening agent, a proper amount of water and edible essence by weight.

s1, dissolving 0.5 part of lactoferrin, 1 part of allicin, 20 parts of propylene glycol, 1.2 parts of sodium lauryl sulfate and 0.2 part of sodium pyrophosphate in deionized water, stirring uniformly in a mixer, putting into an azeotropic boiler, heating to 85 ℃ to make the prepared colloid to be in a uniform, semitransparent and viscous liquid state, and then standing for 2 hours to fully dissolve and expand the colloid for use;

s2, cooling the colloid in the S1 to 65 ℃, putting the azeotropic pot on a stirrer, sequentially adding 20 parts of calcium hydrophosphate, 1 part of sodium alginate and 0.5 part of saccharin sodium while stirring (the rotating speed is 320r/min), and continuously stirring for 2 hours (the rotating speed is 360r/min) to uniformly mix various materials;

s3, cooling the colloid to below 45 ℃, adding a small amount of menthol, and mechanically mixing and stirring uniformly to prepare a paste with certain viscosity and proper consistency;

s4, grinding the paste by a grinder, grinding coarse and hard particles to make the paste fine, uniform and stable, grinding twice, storing and aging lh after the first grinding, and vacuum degassing after the second grinding until the vacuum degree reaches-0.093 MPa for 60 min;

s5, degassing the paste, standing for 4h, sterilizing, filling into a hose, and sealing to obtain the finished toothpaste.

The main quality index evaluation and bacteriostatic effect test of the toothpaste prepared in this example are as follows:

1. determination of appearance, physicochemical index and hygienic index of toothpaste

Taking 4 toothpaste samples, storing 1 toothpaste sample at room temperature, placing the other 3 toothpaste samples in a refrigerator at minus 8 +/-1 ℃, taking out after 8h, immediately placing in a constant temperature incubator at 45 +/-1 ℃, taking out after 8h, recovering to room temperature, opening the cover and observing, wherein the toothpaste does not overflow out of the tube opening. The toothpaste tube is inverted, and no liquid drips out of the tube orifice within 10 s. Compared with the samples stored at room temperature, the paste after extrusion has normal fragrance and color. No excessively hard particles exist, the pH value is 7.98, the foam amount is 170mm, the consistency is 26mm, the total number of bacterial colonies of the toothpaste is 71cfu/g < 500cfu/g of the national standard, pathogenic bacteria are not detected, lead and tombstone are not out of standard, and the toothpaste quality national standard GB8372-2008 and the cosmetic hygiene standard are met.

2. The toothpaste in vitro antibacterial test is as follows

The bacteriostatic ability of the prepared toothpaste is determined by adopting a filter paper method, and the selected strains are as follows: escherichia coli, Streptococcus, Staphylococcus, Fusobacterium nucleatum; the specific method comprises the following steps: uniformly and crossly coating the bacterial culture solution on a culture medium of a culture dish, and placing the culture dish in a constant-temperature incubator at 37 ℃ for 24 hours; respectively taking 5 mu 1 diluted toothpaste liquid medicine with different concentrations and sterilized and heat-removed raw water to soak sterile circular filter paper sheets with the diameter of 6mm, uniformly and symmetrically attaching the small circular filter paper sheets to a central area on a culture medium, placing a culture dish in a constant-temperature incubator at 37 ℃ for culturing for 24h, respectively measuring the diameters of antibacterial zones, preliminarily evaluating and analyzing the antibacterial potential of the experimental toothpaste according to the diameter of the antibacterial zones, wherein the negative indicates that the antibacterial zones are smaller than 1mm, the sample has no antibacterial ability, the dilution concentrations of the pastes are respectively 20, 40, 80, 160 and 320mg/ml, and the experimental results are shown in table 1. Table 1 shows the in vitro antibacterial test results of the toothpaste.

TABLE 1

3. The efficacy of the toothpaste is tested as follows

Randomly selecting 25 patients to carry out toothpaste test pharmacodynamic tests, wherein the subjects are all oral inflammation patients, are male and female unlimited, are between the ages of 22 and 48 years, have a use period of 25 days, and carry out tooth brushing method guidance on all the subjects. Subjects used a uniform toothbrush with a prescribed toothpaste, and were asked to brush their teeth 2 times a day (7: 00-9:00 morning and 7:30-9:30 evening) with a pasteur brushing regimen for at least 2 minutes, with a toothpaste paste of 2 grams at the time of brushing. It is desirable that no other oral hygiene product, such as other types of toothpaste, mouthwash, dental floss, etc., be used during the test. The diet was not restricted and the statistical results are shown in Table 2. Table 2 shows the results of the toothpaste pharmacodynamic test.

TABLE 2

Example 2

Example 2 differs from example 1 in that: the types or amounts of the components vary during the preparation of the toothpaste, as well as certain manufacturing parameters.

The invention provides antibacterial tooth-protecting toothpaste, which is prepared by the following steps:

s1, dissolving 1.25 parts of lactoferrin, 2.5 parts of allicin, 25 parts of sorbitol, 1.0 part of sodium dodecyl sulfate and 0.3 part of sodium pyrophosphate in deionized water, stirring uniformly in a mixer, putting into an azeotropic boiler, heating to 90 ℃ to make the prepared colloid to be uniform, semitransparent and viscous, and then standing for 1.5 hours to fully dissolve and expand the colloid for use.

S2, cooling the colloid obtained in S1 to 70 ℃, placing the azeotropic pot on a stirrer, adding 25 parts of silicon dioxide, 1.2 parts of croscarmellose sodium and 0.6 part of xylitol in this order while stirring (rotation speed of 300r/min), and continuing to stir for 1.5 hours (rotation speed of 350r/min) to uniformly mix the various materials.

S3, cooling the colloid to below 45 ℃, adding a small amount of menthol and orange oil, and mechanically mixing and stirring uniformly to prepare the ointment with certain viscosity and proper consistency.

S4, grinding the paste by a grinder, grinding the coarse and hard particles to fine, uniform and stable the paste, grinding twice, storing and aging for 2h after the first grinding, and vacuum degassing after the second grinding until the vacuum degree reaches-0.096 MPa for 50 min.

S5, degassing the paste, standing for 3h, sterilizing, filling into a hose, and sealing to obtain the finished toothpaste.

1. determination of toothpaste appearance, physicochemical index and sanitary index

Taking 4 toothpaste samples, storing 1 toothpaste sample at room temperature, placing the other 3 toothpaste samples in a refrigerator at minus 8 +/-1 ℃, taking out after 8h, immediately placing in a constant temperature incubator at 45 +/-1 ℃, taking out after 8h, recovering to room temperature, opening the cover and observing, wherein the toothpaste does not overflow out of the tube opening. The toothpaste tube is inverted, and no liquid drips out of the tube orifice within 10 s. Compared with the sample stored at room temperature, the paste after extrusion has normal fragrance and color. No excessively hard particles exist, the pH value is 8.05, the foam quantity is 175mm, the consistency is 28mm, the total number of bacterial colonies of the toothpaste is 90cfu/g < 500cfu/g of the national standard, pathogenic bacteria are not detected, lead and tombstone are not out of standard, and the toothpaste quality national standard GB8372-2008 and cosmetic hygiene standard are met.

2. The toothpaste in vitro antibacterial test is as follows

The bacteriostatic ability of the prepared toothpaste is determined by adopting a filter paper method, and the selected strains are as follows: escherichia coli, Streptococcus, Staphylococcus, and Fusobacterium nucleatum. The specific method comprises the following steps: the bacterial culture solution is evenly and crossly coated on the culture medium of the culture dish, and the culture dish is placed in a constant temperature incubator at 37 ℃ for 24 hours. Respectively taking 5 mu 1 diluted toothpaste liquid medicine with different concentrations and sterilized and heat-removed raw water to soak sterile circular filter paper sheets with the diameter of 6mm, uniformly and symmetrically attaching the small circular filter paper sheets to a central area on a culture medium, placing a culture dish in a constant-temperature incubator at 37 ℃ for culturing for 24h, respectively measuring the diameters of antibacterial zones, preliminarily evaluating and analyzing the antibacterial potential of the experimental toothpaste according to the diameter of the antibacterial zones, wherein the negative indicates that the antibacterial zones are smaller than 1mm, the sample has no antibacterial ability, the dilution concentrations of the pastes are respectively 20, 40, 80, 160 and 320mg/ml, and the experimental results are shown in Table 3. Table 3 in vitro bacteriostatic test results for toothpaste.

TABLE 3

3. The efficacy of the toothpaste is tested as follows

Randomly selecting 25 patients to carry out toothpaste test pharmacodynamic tests, wherein the subjects are all oral inflammation patients, are male and female unlimited, are between the ages of 22 and 48 years, have a use period of 25 days, and carry out tooth brushing method guidance on all the subjects. The subjects used a uniform toothbrush and a prescribed toothpaste, and were asked to brush their teeth 2 times a day (morning 7:00-9:00, evening 7:30-9:30) with the Papanicolaou brushing regimen for at least 2 minutes, with a toothpaste paste on a 2 gram basis. It is desirable that no other oral hygiene product, such as other types of toothpaste, mouthwash, dental floss, etc., be used during the test. Diet was not restricted and the statistical results are shown in table 4. Table 4 contains the results of pharmacodynamic tests of the lactoferrin powder allicin toothpaste.

TABLE 4

Example 3

Example 3 differs from example 1 in that: the types or amounts of the components vary during the preparation of the toothpaste, as well as certain manufacturing parameters.

s1, dissolving 3 parts of lactoferrin, 6 parts of allicin, 20 parts of glycerol, 1.5 parts of methyl cocoa ester-based sodium taurate and 0.3 part of sodium pyrophosphate in deionized water, stirring uniformly in a mixer, putting into a boiling pot, heating to 100 ℃, enabling the prepared colloid to be in a uniform, semitransparent and viscous liquid state, and then standing for lh to enable the colloid to be fully dissolved and expanded for use.

S2, cooling the colloid obtained in the step S1 to 65 ℃, placing the azeotropic pot on a stirrer, adding 35 parts of calcite powder, 0.8 part of guar gum and 0.7 part of sodium cyclamate in sequence while stirring (at the rotating speed of 310r/min), and continuously stirring lh (at the rotating speed of 350r/min) to uniformly mix various materials.

S3, cooling the colloid to below 45 deg.C, adding a small amount of Mentholum and lemon oil, mechanically mixing and stirring to obtain ointment with certain viscosity and proper consistency.

S4, grinding the paste by a grinder, grinding the coarse and hard particles to make the paste fine, uniform and stable, grinding twice, storing and aging for 3h after the first grinding, and vacuum degassing after the second grinding until the vacuum degree reaches-0.096 MPa for 40 min.

S5, degassing the paste, standing for 2 hours, sterilizing, filling into a hose, and sealing to obtain the finished product.

The toothpaste prepared in the example has the following quality indexes and bacteriostatic effect

1. Appearance, physical and chemical indexes, and sanitation indexes of ointment

Taking 4 toothpaste samples, storing 1 toothpaste sample at room temperature, placing the other 3 toothpaste samples in a refrigerator at minus 8 +/-1 ℃, taking out after 8h, immediately placing in a constant temperature incubator at 45 +/-1 ℃, taking out after 8h, recovering to room temperature, opening the cover and observing, wherein the toothpaste does not overflow out of the tube opening. The toothpaste tube is inverted, and no liquid drips out of the tube orifice within 10 s. Compared with the sample stored at room temperature, the paste after extrusion has normal fragrance and color. No hard particles exist, the pH value is 8.05, the foam amount is 175mm, the consistency is 28mm, the total number of bacterial colonies of the toothpaste is 90cfu/g which is less than 500cfu/g of the national standard, pathogenic bacteria are not detected, lead and tablet do not exceed the standard, and the toothpaste meets the national standard GB8372-2008 of toothpaste quality and the cosmetic hygiene Specification.

2. The toothpaste bacteriostasis test is as follows

The selected strains are as follows: escherichia coli, Streptococcus, Staphylococcus, and Fusobacterium nucleatum. Soaking sterile circular filter paper sheets with the diameter of 6mm in heat removal raw water, uniformly and symmetrically attaching the small circular filter paper sheets to a central area on a culture medium, placing a culture dish in a constant-temperature incubator at 37 ℃ for culturing for 24h, respectively measuring the diameters of inhibition zones, preliminarily evaluating and analyzing the antibacterial potential of the experimental toothpaste according to the diameter of the antibacterial zone, wherein the "-" indicates that the inhibition zones are smaller than 1mm, the sample has no antibacterial ability, the dilution concentrations of the paste are respectively 20, 40, 80, 160 and 320mg/ml, and the experimental results are shown in table 5. Table 5 results of in vitro bacteriostatic tests for toothpaste.

TABLE 5

3. The efficacy test of toothpaste is as follows

Randomly selecting 25 patients to carry out toothpaste test pharmacodynamic tests, wherein the subjects are all oral inflammation patients, are male and female unlimited, are between the ages of 22 and 48 years, have a use period of 25 days, and carry out tooth brushing method guidance on all the subjects. Subjects used a uniform toothbrush with a prescribed toothpaste, and were asked to brush their teeth 2 times a day (7: 00-9:00 morning and 7:30-9:30 evening) with a pasteur brushing regimen for at least 2 minutes, with a toothpaste paste of 2 grams at the time of brushing. It is desirable that no other oral hygiene product, such as other types of toothpaste, mouthwash, dental floss, etc., be used during the test. Diet was not restricted and the statistical results are shown in table 6. Table 6 results of pharmacodynamic tests of the lactoferrin containing powder allicin toothpaste.

TABLE 6

The lactoferrin can improve the resistance of the lactoferrin and effectively prevent or treat viral infection. Meanwhile, iron absorption is promoted, and anemia is prevented. For people with low immunity, lactoferrin can help them to stimulate, build and repair immune systems and enhance disease resistance. Exogenous lactoferrin is usually derived from mammalian milk, is not easily tolerogenic, and has a significant antinociceptive effect on lactoferrin itself, being able to bind to the bacterial wall, together with its molecularly specific peptidic fragment. This stretch is located at the N-loop terminus of lactoferrin and is produced by degradation of the lactoferrin N-terminus in vitro by some proteases, such as trypsin. Related studies have shown that lactoferrin is able to target the H (+) -atpase and interfere with proton transport on the cell membrane, thus posing a fatal threat to microorganisms. Lactoferrin also has broad-spectrum antiviral properties and has varying degrees of inhibitory effects against various viruses.

Allicin has strong antibacterial and anti-inflammatory effects, and has obvious inhibiting or killing effects on various pathogenic bacteria such as staphylococcus, meningitis, pneumococcus, streptococcus, diphtheria, dysentery, Escherichia coli, typhoid, paratyphoid, pertussis, tubercle bacillus, vibrio cholerae and the like. Can be used for treating acute bacillary dysentery, pertussis, infantile diarrhea, lobar pneumonia, pulmonary tuberculosis, wound suppuration, trachoma, etc. The principle of allicin is that the oxygen atom in allicin molecule combines with the sulfhydryl group in cysteine molecule, which is essential for bacteria growth and reproduction, to inhibit the growth and reproduction of bacteria. Has no toxicity, no side effect, no drug residue and no drug resistance, and is the best additive for replacing antibiotics and producing safe and pollution-free products.

The invention adds lactoferrin powder and garlicin as effective components into toothpaste, has obvious improvement on dental plaque, gum swelling and pain and oral peculiar smell, has obvious functions of diminishing inflammation, inhibiting bacteria and resisting allergy, can be used for preventing and treating stomatitis, gingivitis, stomatitis, oral ulcer and the like, reduces oral diseases, has simple preparation process and has obvious public health value.

While the embodiments of the present invention have been described in detail, the present invention is not limited thereto, and various changes can be made without departing from the gist of the present invention within the knowledge of those skilled in the art.

Claims

1. The bacteriostatic tooth-protecting toothpaste is characterized by comprising 0.5-8 parts of lactoferrin, 0.5-8 parts of allicin, 10-30 parts of wetting agent, 15-45 parts of rubbing agent, 0.5-8.5 parts of foaming agent, 0.4-1.6 parts of adhesive, 0.15-0.3 part of stabilizer, 0.2-0.8 part of sweetener, a proper amount of water and edible essence according to the weight ratio.

2. A bacteriostatic tooth-protecting toothpaste according to claim 1 wherein the humectant comprises but is not limited to one or more of propylene glycol, sorbitol, glycerin, glycerol and polyethylene glycol.

3. The bacteriostatic tooth-protecting toothpaste according to claim 1, wherein the abrasive agent comprises one or more of calcium hydrogen phosphate, silica, calcium carbonate, aluminum hydroxide, heavy calcium carbonate and light calcium carbonate.

4. The bacteriostatic tooth-protecting toothpaste according to claim 1, wherein the foaming agent comprises one or more of sodium lauryl sulfate, sodium N-lauroyl sarcosinate and sodium methyl cocoyl taurate.

5. The bacteriostatic tooth-protecting toothpaste according to claim 1, wherein the binder comprises one or more of sodium alginate, sodium carboxymethylcellulose, xanthan gum, hydroxyethyl cellulose, guar gum, acacia gum and carrageenan.

6. The bacteriostatic tooth-protecting toothpaste according to claim 1, wherein the stabilizer is sodium pyrophosphate.

7. The antibacterial tooth-protecting toothpaste according to claim 1, wherein the sweetening agent comprises one or more of but not limited to saccharin sodium, sucrose, xylitol, sodium cyclamate and aspartame.

8. The antibacterial tooth-protecting toothpaste according to claim 1, wherein the flavoring essence comprises one or more of but not limited to menthol, spearmint oil, lime oil, lemon oil, orange oil, clove oil, jasmine oil, cherry blossom oil and peppermint oil.

9. A method for preparing bacteriostatic tooth-protecting toothpaste according to any one of claims 1 to 8, which comprises the following steps:

s3, cooling the colloid to below 45 ℃, adding other auxiliary agents, and stirring to prepare a paste;

10. The method for preparing bacteriostatic tooth-protecting toothpaste according to claim 9, wherein the mixing in S1 is carried out in a blender mixer; heating in an azeotropic pot to 75-100 deg.C, and standing for 0.5 hr or more; cooling to 65-70 ℃ in S2; the stirring speed is 300-400r/min, and the stirring time is more than 0.5 h; the grinding in S4 was carried out by a grinder in two passes, the first pass was followed by storage and the second pass was followed by vacuum degassing.