CN114927034A - Three-dimensional teaching aid for synthesizing sex hormone-testosterone - Google Patents

Three-dimensional teaching aid for synthesizing sex hormone-testosterone Download PDF

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Publication number
CN114927034A
CN114927034A CN202210444726.9A CN202210444726A CN114927034A CN 114927034 A CN114927034 A CN 114927034A CN 202210444726 A CN202210444726 A CN 202210444726A CN 114927034 A CN114927034 A CN 114927034A
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mold
mould
testosterone
teaching aid
cell membrane
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CN114927034B (en
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桂林
徐彪雄
李强
邓慧欣
徐斯琳
李铱婷
戴钰苑
王亿鸿
叶梓东
黄心研
李文俊
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Guangzhou University
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Guangzhou University
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    • GPHYSICS
    • G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

The invention discloses a three-dimensional teaching aid for synthesizing sex hormone-testosterone, which comprises a cell membrane shell mould and a teaching aid support, wherein the teaching aid support comprises a vertical rod connected with the cell membrane shell mould and an annular assembly connected with the vertical rod, an iron plate for sealing is fixedly arranged on the inner wall of the cell membrane shell mould close to an opening, the iron plate is sunken in the cell membrane shell mould, a detachable channel protein mould is arranged on the outer wall of the cell membrane shell mould higher than the sealing, a layer of white film is attached to the outer wall of the surface of the iron plate, and an organelle module and a related factor module are arranged on the surface of the iron plate through magnetic attraction. The teaching aid is novel in structural design, easily available in materials and convenient to assemble, teachers can conveniently observe students in teaching in a manner similar to a globe, small parts on the teaching aid are detachable so as to facilitate teachers to carding and synthesizing steps to conveniently absorb knowledge, and more organelles can be produced to expand biological learning in more aspects.

Description

Three-dimensional teaching aid for synthesizing sex hormone-testosterone
Technical Field
The invention relates to the field of teaching aids, in particular to a three-dimensional teaching aid for synthesizing sex hormone-testosterone.
Background
The hypothalamus secretes gonadotropin-releasing hormone to stimulate the pituitary to secrete luteinizing hormone LH, LH is combined with a luteinizing hormone receptor on the surface of interstitial cells of testis, and then adenylate cyclase is activated under the action of G protein to promote the production of cAMP in cells, so that PKA is activated, the phosphorylation of cAMP response element binding protein is promoted, and the synthesis of acute regulatory protein by steroids is activated. The activated StAR accelerates the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane by binding to a transporter on the outer mitochondrial membrane. Secondly, converting cholesterol into pregnenolone on an inner mitochondrial membrane through cytochrome P450 cholesterol side chain lyase, transporting the pregnenolone to an endoplasmic reticulum, carrying out enzymolysis on the pregnenolone into progesterone under the action of 3 beta-hydroxysteroid dehydrogenase, catalyzing the progesterone into androstenedione, and finally generating testosterone under the action of 17 beta-hydroxysteroid dehydrogenase, wherein the content of testosterone knowledge points in biological classes is shown above; teachers can be boring without assistance of teaching aids when teaching the contents in a classroom, the defects of few types, single structure, difficulty in manufacturing, inconvenience in operation and the like exist in the conventional teaching aids, and biological teaching aids are few and few, so that a newly designed synthetic hormone-testosterone three-dimensional teaching aid needs to be provided.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a three-dimensional teaching aid for synthesizing sex hormone-testosterone, which solves the problems by improving the structural design and the preparation materials.
(II) technical scheme
In order to achieve the above purpose, the invention provides the following technical scheme:
the utility model provides a synthetic sex hormone-testosterone's three-dimensional teaching aid, includes cell membrane shell mould and teaching aid support, the teaching aid support includes the pole setting of being connected with cell membrane shell mould and the annular subassembly of being connected with the pole setting, and the pole setting bottom fixed mounting in the teaching aid support has the base, cell membrane shell mould is hemispherical of interior sky form, fixed mounting has the iron plate that is used for sealing on the inner wall of cell membrane shell mould that is close to the opening part, and iron plate caves in cell membrane shell mould, it is provided with detachable passageway protein mould on the outer wall of department of sealing to exceed in the cell membrane shell mould, the surperficial outer wall of iron plate is pasted with the one deck white film, and the surface of the attached white film of iron plate is provided with organelle module and correlation factor module through magnetism.
Preferably, the cell membrane shell mold is made of plastic, and the surface of the cell membrane shell mold is painted yellow.
Preferably, the organelle module comprises a nucleus mould, an endoplasmic reticulum mould and a mitochondrion mould, wherein the nucleus mould is a hemisphere made of clay or plastics, the surface of the nucleus mould is coated with yellow, and the outer wall of the nucleus mould is drawn with a nuclear pore, a nucleolus and chromatin grains in a nucleus;
the inner net mold is also made of clay or plastic, the surface of the inner net mold is coated with pink, and a plurality of groups of granules made of clay are adhered to the outer wall of the inner net mold;
the mitochondrial mould is also made of clay or plastic, the mitochondrial mould is semi-ellipsoidal, the surface of the mitochondrial mould is coated with brown, and the outer wall of the cell nucleus mould is drawn with the structural lines of mitochondria.
Preferably, magnets are embedded in the outer walls of the smooth surfaces at the bottoms of the cell nucleus die, the endoplasmic reticulum die and the mitochondrion die in the cell organelle module, the cell nucleus die, the endoplasmic reticulum die and the mitochondrion die are adsorbed on the surface of the iron plate through the magnets, the cell nucleus die and the endoplasmic reticulum die are close to each other, and intervals exist among the mitochondrion die, the cell nucleus die and the endoplasmic reticulum die.
Preferably, the correlation factor module comprises a plurality of groups of cholesterol molds, cAMP molds, pregnenolone molds and testosterone molds, the cholesterol molds, cAMP molds, pregnenolone molds and testosterone molds are all made of particles made of clay (or plastic), the volumes of the cholesterol molds, cAMP molds, pregnenolone molds and testosterone molds are larger than the volume of the particles adhered to the outer wall of the endoplasmic reticulum mold, and the surfaces of the cholesterol molds, cAMP molds, pregnenolone molds and testosterone molds are coated with different colors for distinguishing.
Preferably, the smooth outer walls of the bottoms of the cholesterol mold, the cAMP mold, the pregnenolone mold and the testosterone mold in the correlation factor module are all embedded with small magnets, and the cholesterol mold, the cAMP mold, the pregnenolone mold and the testosterone mold are adsorbed on the surface of an iron plate through the magnets.
Preferably, a plurality of groups of cholesterol molds are unevenly distributed on the surface of the iron plate, a plurality of groups of cAMP molds are spaced between the endoplasmic reticulum mold and the mitochondrial mold, a plurality of groups of pregnenolone molds are evenly distributed around the endoplasmic reticulum mold and the mitochondrial mold, and a plurality of groups of testosterone molds are distributed around the endoplasmic reticulum mold and the nuclear mold.
Preferably, the channel protein mold is an ellipsoid made of paperboard, clay or plastic, the surface of the channel protein mold is painted in yellow, and the bottom of the channel protein mold is provided with an open clamping groove used for being clamped on the cell membrane shell mold.
(III) advantageous effects
Compared with the prior art, the three-dimensional teaching aid for the synthetic sex hormone-testosterone provided by the invention has the following beneficial effects:
1. the three-dimensional teaching aid for synthesizing sex hormone-testosterone overcomes various defects of the existing product by improving the structural design and preparing materials. The mode that specifically adopts similar globe so that the teacher can conveniently observe for students in the teaching, the widget on the teaching aid such as endoplasmic reticulum, cell nucleus, mitochondria, cholesterol, membrane protein etc. all can dismantle in order to make things convenient for the mr to comb synthetic step with the study and conveniently absorb knowledge, and follow-up can also produce more organelles and expand the biological learning of more aspects, for example the synthesis of protein etc. provides very big facility to mr's teaching.
2. The three-dimensional teaching aid for synthesizing sex hormone-testosterone is composed of a main body cell membrane support and interactive cell structures, wherein the interactive modules in cells are combined with an iron plate on the support through a magnet of the interactive modules, and show behaviors of cell structures in the testosterone synthesis process during executing functions, so that the process of synthesizing and secreting testosterone is vividly and vividly shown to students, and the three-dimensional teaching aid has attraction for the students and is very convenient for teaching.
3. The three-dimensional teaching aid for the synthetic sex hormone-testosterone is characterized in that an iron plate is inlaid, all parts are detachably connected through magnetic force, supporting points are provided for an interactive module, and channel proteins outside a support are inlaid in an opening mode, so that the inlaying characteristics of the three-dimensional teaching aid on cell membranes are reflected.
4. The three-dimensional teaching aid for synthesizing sex hormone-testosterone comprises all cell structures such as mitochondria, endoplasmic reticulum and the like, and the interactive modules show high interactivity due to the fact that magnets are attached to the interactive modules and the iron plates on the support are combined, so that the purpose of displaying the synthetic route of the lipid more clearly and clearly is achieved.
5. The three-dimensional teaching aid for the synthetic sex hormone-testosterone adopts a scheme that the teaching aid is three-dimensional, the materials are easy to obtain, the environment is protected, and the manufacturing is convenient, so that the mass production of a factory can be realized, a scheme can be provided for independent manufacturing of teachers in life, and the applicability of the teaching aid is improved.
Drawings
FIG. 1 is a schematic diagram of the overall three-dimensional appearance structure of the three-dimensional teaching aid of the invention;
FIG. 2 is a schematic diagram of the three-dimensional shape structure of the channel protein mold of the three-dimensional teaching aid of the invention;
FIG. 3 is a schematic cross-sectional view of an organelle module of the three-dimensional teaching aid of the present invention.
In the figure: 1. a cell membrane housing mold; 2. a teaching aid support; 3. a base; 4. an iron plate; 5. an organelle module; 6. a correlation factor module; 7. a channelprotein mold; 8. a cell nucleus mold; 9. an endoplasmic reticulum mold; 10. a mitochondrial mould; 11. a cholesterol mold; 12. a cAMP mold; 13. a pregnenolone mold; 14. a testosterone mould; 15. a card slot; 16. and a magnet.
Detailed Description
The following describes a specific embodiment of the present invention in detail with reference to the accompanying drawings and examples.
Example (b):
referring to fig. 1-3, the three-dimensional teaching aid for synthetic hormone-testosterone provided by this embodiment comprises a cell membrane shell mold 1 and a teaching aid support 2, wherein the teaching aid support 2 comprises a vertical rod connected with the cell membrane shell mold 1 and an annular component connected with the vertical rod, a base 3 is fixedly mounted at the bottom end of the vertical rod in the teaching aid support 2, the cell membrane shell mold 1 is of a semi-sphere with a hollow inner part, an iron plate 4 for sealing is fixedly mounted on the inner wall of the cell membrane shell mold 1 near the opening, the iron plate 4 is recessed in the cell membrane shell mold 1, a detachable channel protein mold 7 is arranged on the outer wall of the cell membrane shell mold 1 above the opening, a layer of white membrane is attached on the outer wall of the iron plate 4, so as to facilitate observation of students in teaching, and an organelle module 5 and a related factor module 6 are arranged on the surface of the iron plate 4 attached to the white membrane through magnetic attraction, the teaching aid main part adopts the three-dimensional structure similar to a globe, and a teacher can more easily show and observe students in teaching.
The cell membrane shell mold 1 is made of plastic, and the surface of the cell membrane shell mold 1 is painted yellow.
The organelle module 5 comprises a cell nucleus mould 8, an endoplasmic reticulum mould 9 and a mitochondrion mould 10, wherein the cell nucleus mould 8 is a hemisphere made of clay or plastics, the surface of the cell nucleus mould 8 is painted into yellow, and the outer wall of the cell nucleus mould 8 is drawn with a nuclear pore, a nucleolus and chromatin grains in a cell nucleus;
the endoplasmic reticulum mould 9 is also made of clay or plastic, the surface of the endoplasmic reticulum mould 9 is coated with pink, a plurality of groups of granular bodies made of clay are adhered to the outer wall of the endoplasmic reticulum mould 9, and the granular bodies are used for representing ribosomes attached to the surface of a crude endoplasmic reticulum, vesicular retention bubbles and the like;
the mitochondrial mould 10 is also made of clay or plastic, the mitochondrial mould 10 is semi-ellipsoidal, the surface of the mitochondrial mould is coated with brown, and the outer wall of the cell nucleus mould 8 is drawn with mitochondrial structure grains.
The magnet 16 is embedded in the outer walls of the smooth surfaces of the bottoms of the cell nucleus mold 8, the endoplasmic reticulum mold 9 and the mitochondria mold 10 in the cell organelle module 5, the cell nucleus mold 8, the endoplasmic reticulum mold 9 and the mitochondria mold 10 are adsorbed on the surface of the iron plate 4 through the magnet 16, the cell nucleus mold 8 and the endoplasmic reticulum mold 9 are close to each other, and a space exists between the mitochondria mold 10 and the cell nucleus mold 8 as well as between the mitochondria mold 9.
The correlation factor module 6 comprises a plurality of groups of cholesterol molds 11, cAMP molds 12, pregnenolone molds 13 and testosterone molds 14, wherein the cholesterol molds 11, the cAMP molds 12, the pregnenolone molds 13 and the testosterone molds 14 are all made of clay or plastic particles, the volumes of the cholesterol molds 11, the cAMP molds 12, the pregnenolone molds 13 and the testosterone molds 14 are larger than the volume of particles adhered to the outer wall of the endoplasmic reticulum mold 9, different colors for distinguishing are coated on the surfaces of the cholesterol molds 11, the cAMP molds 12, the pregnenolone molds 13 and the testosterone molds 14, the colors of all the molds in the correlation factor module 6 can be determined, and names of substances represented on the surfaces can be better distinguished.
The small magnets 16 are embedded in the smooth outer walls of the bottoms of the cholesterol mold 11, the cAMP mold 12, the pregnenolone mold 13 and the testosterone mold 14 in the related factor module 6, the cholesterol mold 11, the cAMP mold 12, the pregnenolone mold 13 and the testosterone mold 14 are adsorbed on the surface of the iron plate 4 through the magnets 16, the related factor module 6 further comprises a CREB mold, a StAR mold and the like, the manufacturing materials of the related factor module are the same as those of the molds, and the small magnets 16 are embedded in the bottoms of the related factor module 6.
The multiple groups of cholesterol molds 11 are unevenly distributed on the surface of the iron plate 4, the multiple groups of cAMP molds 12 are arranged at intervals between the endoplasmic reticulum mold 9 and the mitochondrial mold 10, the multiple groups of pregnenolone molds 13 are evenly distributed around the endoplasmic reticulum mold 9 and the mitochondrial mold 10, and the multiple groups of testosterone molds 14 are distributed around the endoplasmic reticulum mold 9 and the nuclear mold 8.
The channel protein mould 7 is an ellipsoid made of paperboard, clay or plastic, the surface of the channel protein mould 7 is painted in yellow, the bottom of the channel protein mould 7 is provided with an opening-shaped clamping groove 15 which is clamped on the cell membrane shell mould 1, and the channel protein mould 7 is embedded in an opening mode to embody the embedding characteristic of the channel protein mould on the cell membrane.
The whole body of the invention is similar to a globe, and each part is in a detachable assembly mode, and each part can be mutually attracted and fixed through magnetic force through the improvement of preparation materials, thereby breaking through various limitations of the existing products. According to the teaching aid, the organelle module 5 and the related factor module 6 can be adsorbed on the iron plate 4 through the magnet 16, a teacher can move different model components in the organelle module 5 and the related factor module 6 on the surface of the iron plate 4, the channel protein mould 7 can be clamped on the cell membrane shell mould 1 through the clamping groove 15, the channel protein mould 7 is convenient to install and detach, the teaching aid is very beneficial to the teaching of the teacher, the process of synthesizing and secreting testosterone is vividly displayed to students, the teaching aid can show experience of observation in cells through three-dimensional design, the teaching aid is very attractive to students, the learning interest of the students can be stimulated, the teaching aid adopts a globe-like mode to enable the teacher to conveniently observe the students in the teaching, and small parts on the teaching aid, such as endoplasmic reticulum, mitochondria, cholesterol, and the like, The membrane protein and the like are all detachable so as to facilitate teachers to carding and synthesizing steps and absorb knowledge conveniently.
Although a few embodiments of the present invention have been shown and described, it would be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in the embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the claims and their equivalents.

Claims (8)

1. The utility model provides a synthetic sex hormone-testosterone's three-dimensional teaching aid, includes cell membrane shell mould (1) and teaching aid support (2), teaching aid support (2) include the pole setting of being connected with cell membrane shell mould (1) and the annular assembly of being connected with the pole setting, and the pole setting bottom fixed mounting in teaching aid support (2) has base (3), its characterized in that: fixed mounting has iron plate (4) that are used for sealing on the inner wall of being close to the opening part of cell membrane shell mould (1), and iron plate (4) cave in cell membrane shell mould (1), be provided with detachable channel protein mould (7) on the outer wall of the department of sealing in cell membrane shell mould (1) the higher, the surface outer wall of iron plate (4) is pasted and is had one deck white film, and the surface of the attached white film of iron plate (4) is provided with organelle module (5) and relevant factor module (6) through magnetism.
2. The stereoscopic teaching aid of synthetic sex hormone-testosterone according to claim 1, characterized in that: the cell membrane shell mold (1) is made of plastic, and the surface of the cell membrane shell mold (1) is coated in yellow.
3. The stereoscopic teaching aid of synthetic sex hormone-testosterone according to claim 1, characterized in that: the organelle module (5) comprises a cell nucleus mould (8), an endoplasmic reticulum mould (9) and a mitochondrion mould (10), wherein the cell nucleus mould (8) is a hemisphere made of clay, the surface of the cell nucleus mould (8) is painted in yellow, and the outer wall of the cell nucleus mould (8) is drawn with a nuclear pore, a nucleolus and a chromatin texture in a cell nucleus;
the inner net mold (9) is also made of clay, the surface of the inner net mold (9) is coated with pink, and a plurality of groups of granules made of clay are adhered to the outer wall of the inner net mold (9);
the mitochondria mould (10) is also made of clay, the mitochondria mould (10) is semi-ellipsoidal, the surface of the mitochondria mould (10) is coated with brown color, and the outer wall of the cell nucleus mould (8) is drawn with mitochondria structure grains.
4. The stereoteaching aid for the synthesis of sex hormone-testosterone according to claim 3, wherein: the cell nucleus mold (8), the endoplasmic reticulum mold (9) and the mitochondria mold (10) in the cell organelle module (5) are all embedded with a magnet (16) on the outer wall of the smooth surface at the bottom, the cell nucleus mold (8), the endoplasmic reticulum mold (9) and the mitochondria mold (10) are adsorbed on the surface of the iron plate (4) through the magnet (16), the cell nucleus mold (8) and the endoplasmic reticulum mold (9) are close to each other, and intervals exist between the mitochondria mold (10) and the cell nucleus mold (8) and between the mitochondria mold (9).
5. The stereoscopic teaching aid of synthetic sex hormone-testosterone according to claim 3, characterized in that: the correlation factor module (6) comprises a plurality of groups of cholesterol moulds (11), cAMP moulds (12), pregnenolone moulds (13) and testosterone moulds (14), wherein the cholesterol moulds (11), the cAMP moulds (12), the pregnenolone moulds (13) and the testosterone moulds (14) are all made of clay, and the volumes of the cholesterol moulds (11), the cAMP moulds (12), the pregnenolone moulds (13) and the testosterone moulds (14) are larger than the volume of adhered particles on the outer wall of the endoplasmic reticulum mould (9).
6. The stereoteaching aid for the synthesis of sex hormone-testosterone according to claim 5, wherein: the small magnet (16) is embedded in the smooth outer wall of the bottom of a cholesterol mold (11), a cAMP mold (12), a pregnenolone mold (13) and a testosterone mold (14) in the correlation factor module (6), and the cholesterol mold (11), the cAMP mold (12), the pregnenolone mold (13) and the testosterone mold (14) are adsorbed on the surface of the iron plate (4) through the magnet (16).
7. The stereoteaching aid for the synthesis of sex hormone-testosterone according to claim 6, wherein: the cholesterol molds (11) are unevenly distributed on the surface of the iron plate (4), the cAMP molds (12) are spaced between the endoplasmic reticulum mold (9) and the mitochondrial mold (10), the pregnenolone molds (13) are evenly distributed around the endoplasmic reticulum mold (9) and the mitochondrial mold (10), and the testosterone molds (14) are distributed around the endoplasmic reticulum mold (9) and the nuclear mold (8).
8. The stereoscopic teaching aid of synthetic sex hormone-testosterone according to claim 1, characterized in that: the channel protein mold (7) is an ellipsoid made of a paperboard, the surface of the channel protein mold (7) is painted in yellow, and the bottom of the channel protein mold (7) is provided with an opening-shaped clamping groove (15) used for being clamped on the cell membrane shell mold (1).
CN202210444726.9A 2022-04-26 2022-04-26 Stereo teaching aid for synthesizing sex hormone-testosterone Active CN114927034B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103426349A (en) * 2013-08-30 2013-12-04 苏州大学 N type acetylcholine receptor structural model teaching tool
CN104299499A (en) * 2014-09-28 2015-01-21 丁玉清 Fluid mosaic model experimental device for biological membrane
CN208384860U (en) * 2017-12-01 2019-01-15 深圳华大基因科技有限公司 cell model
CN209729262U (en) * 2019-01-28 2019-12-03 青华科教仪器有限公司 Removable animal cell models
CN212990473U (en) * 2020-09-30 2021-04-16 吴小丽 Biological structure demonstration teaching aid for student teaching

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103426349A (en) * 2013-08-30 2013-12-04 苏州大学 N type acetylcholine receptor structural model teaching tool
CN104299499A (en) * 2014-09-28 2015-01-21 丁玉清 Fluid mosaic model experimental device for biological membrane
CN208384860U (en) * 2017-12-01 2019-01-15 深圳华大基因科技有限公司 cell model
CN209729262U (en) * 2019-01-28 2019-12-03 青华科教仪器有限公司 Removable animal cell models
CN212990473U (en) * 2020-09-30 2021-04-16 吴小丽 Biological structure demonstration teaching aid for student teaching

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