CN114886977B

CN114886977B - Traditional Chinese medicine composition for treating postoperative dysuria

Info

Publication number: CN114886977B
Application number: CN202210648602.2A
Authority: CN
Inventors: 范艺缤
Original assignee: Nanchong Traditional Chinese Medicine Hospital
Current assignee: Nanchong Traditional Chinese Medicine Hospital
Priority date: 2022-06-09
Filing date: 2022-06-09
Publication date: 2023-06-23
Anticipated expiration: 2042-06-09
Also published as: CN114886977A

Abstract

The invention discloses a traditional Chinese medicine composition for treating postoperative dysuria, which is prepared from the following raw materials in parts by weight: 30-45 parts of amber, 10-20 parts of platycodon grandiflorum, 15-30 parts of poria cocos, 5-15 parts of cinnamon, 15-30 parts of pollen typhae, 15-30 parts of climbing fern spore, 15-30 parts of crinis carbonisatus, 15-20 parts of talcum, 15-20 parts of red paeony root, 5-10 parts of borneol and 5-10 parts of licorice root tip. Based on the basic ideas of 'disease prevention before disease prevention' and 'disease prevention' of traditional Chinese medicine, the invention adopts the 'five viscera coherent method' to treat postoperative dysuria, and selects fine medicines together into fine powder to prepare the medicine which is applied to the lower abdomen bladder body surface projection area, thus obtaining good clinical curative effect.

Description

Traditional Chinese medicine composition for treating postoperative dysuria

Technical Field

The invention particularly relates to a traditional Chinese medicine composition for treating postoperative dysuria.

Background

The postoperative urination is unfavorable, refers to the difficult urination after the operation, dribbling urination and painful urination, even the difficult urination occlusion is a disease which is mainly represented, is one of the common complications after anorectal operation, not only increases the pain of patients, but also can influence the rehabilitation of the patients, cause a plurality of complications and even endanger the lives due to untimely treatment. Western medicine treatment mainly comprises intramuscular injection of neostigmine on single-sided gluteus maximus. The neostigmine methosulfate injection is anticholinesterase medicine and is used in antagonizing the residual muscle relaxing effect of non-depolarized muscle relaxing medicine to treat urination. The dosage is usually 0.25-1mg once for subcutaneous or intramuscular injection, 1-3 times a day. The maximum amount is 1mg once, 5mg a day, subcutaneously or intramuscularly. The clinical application has unsatisfactory curative effect, and can cause drug eruption, nausea, vomiting, diarrhea, lacrimation, salivation and the like when the drug eruption is in large dose, and can cause a plurality of adverse reactions such as ataxia, convulsion, coma, dysphoria, anxiety and fear, even cardiac arrest and the like when the drug eruption is severe.

The traditional Chinese medicine considers that the postoperative dysuria belongs to the category of uroschesis or stranguria, is one of the common postoperative complications, and the clinical report of the basic pathogenesis mainly comprises the defect of bladder qi transformation caused by damp-heat stasis, but has poor application curative effect. It is quite unknown that the damp-heat stasis syndrome is marked by the symptoms, and the treatment of the disease is not carried out from the aspect of treating the disease, so that the curative effect is poor. The qi transformation function of the urinary bladder is closely related to the regulation of heart, lung, spleen, kidney and liver. The lung is the upper source of water, and if lung qi fails to descend, body fluids are not distributed, water passage is not regulated properly, and the bladder cannot be transported downwards; if spleen fails to transport and transform, clear yang will not rise and oil yin will not fall; or kidney qi is damaged, fire of the gate is weakened, bladder qi is not authorized, and the kidney qi is drowned; the liver governs smoothing flow of qi, and its meridian goes around the yin device to resist the lower abdomen, liver failing to smooth qi-draining, the triple energizer qi failing to function, and the water channel is blocked to cause damp-heat stasis, so that urination is not favored.

The traditional Chinese medicine considers that the human body is a unified organism, is structurally and mutually connected, is mutually restricted in physiology and is mutually influenced in pathology. The bladder is orderly opened and closed, and the urine is excreted to a degree, so that the normal functions of the five zang organs, such as heart, liver, spleen, lung and kidney, are not separated, and the normal functions of the combined synergistic effect of restriction and transformation between the five zang organs, the opposition and the unification of yin and yang and ascending, descending, entering and exiting of qi are not separated. However, no report on the basis of the basic pathogenesis of the present disease, namely the five viscera disorder, which is caused by adopting the five viscera coherent method to treat the postoperative dysuria exists at present.

Disclosure of Invention

The invention provides a traditional Chinese medicine composition for treating postoperative dysuria, which is prepared from the following raw materials in parts by weight:

25-45 parts of amber, 10-20 parts of platycodon grandiflorum, 15-30 parts of poria cocos, 5-15 parts of cinnamon, 15-30 parts of pollen typhae, 15-30 parts of climbing fern spore, 15-30 parts of carbonized hair, 10-20 parts of talcum, 10-20 parts of red paeony root, 5-10 parts of borneol and 5-10 parts of licorice root tip.

Further, the material is prepared from the following raw materials in parts by weight:

25-45 parts of amber, 10-20 parts of platycodon grandiflorum, 15-30 parts of poria cocos, 8-15 parts of cinnamon, 20-30 parts of pollen typhae, 20-30 parts of climbing fern spore, 20-30 parts of carbonized hair, 10-20 parts of talcum, 10-20 parts of red paeony root, 5-10 parts of borneol and 5-10 parts of licorice root tip.

45 parts of amber, 20 parts of platycodon grandiflorum, 30 parts of poria cocos, 15 parts of cinnamon, 30 parts of pollen typhae, 30 parts of climbing fern spore, 30 parts of crinis carbonisatus, 20 parts of talcum, 20 parts of red paeony root, 10 parts of borneol and 10 parts of licorice root tip.

Further, the preparation is prepared by taking medicinal powder of the raw material medicine or water or organic solvent extract of the raw material medicine as an active ingredient and adding pharmaceutically acceptable auxiliary materials.

Further, the preparation is an external preparation.

Further, the external preparation is a emplastrum, a solution and an aerosol.

Further, the plaster is a medicine plaster which is stuck to the lower abdomen bladder body surface projection area.

The invention also provides a preparation method of the pharmaceutical composition, which comprises the following steps:

(1) Weighing the raw materials according to the proportion;

(2) Grinding the raw materials into powder, or extracting with water or organic solvent, and adding adjuvants or auxiliary components commonly used in medicine.

The invention finally provides application of the medicinal composition in preparing medicines for treating postoperative dysuria.

Further, the medicine is a medicine for treating damp-heat stasis type postoperative dysuria.

The theory of traditional Chinese medicine holds that the human body is an organic whole, and all the components of the human body are mutually connected in function and mutually influenced in pathology. The bladder is orderly opened and closed, and the urine is excreted to a degree, so that the normal functions of the five zang organs, such as heart, liver, spleen, lung and kidney, are not separated, and the normal functions of the combined synergistic effect of restriction and transformation between the five zang organs, the opposition and the unification of yin and yang and ascending, descending, entering and exiting of qi are not separated. Therefore, the invention is based on the traditional Chinese medicine integral concept, based on the basic ideas of 'disease prevention before disease prevention' and 'disease prevention' of traditional Chinese medicine, adopts the 'five viscera coherent regulation method' to treat postoperative dysuria, and carefully selects fine medicines together into fine powder to prepare the medicine to be applied and stuck to the lower abdomen bladder body surface projection area, thus obtaining good clinical curative effect.

In the composition, amber is taken as a monarch, platycodon grandiflorum, poria cocos, cinnamon and pollen typhae are taken as ministers, climbing fern spore, carbonized hair, talcum and red paeony root are taken as assistants, and borneol and licorice root tip are taken as guides. "Su Mi-Ling lan Mi Dian Lun (Su Mi question and Ling lan Mi Dian Lun (Ling Mi question and Ling lan Mi dictionary) for heart people, principal officials, mind and expression. The heart stores spirit and is used for the mind, and viscera, hundred and body are all listened to and lived in the heart. Amber is described in the section: the five zang organs are treated by the actions of regulating the spirit, removing blood stasis and treating five stranguria. The amber is used as the principal ingredient in the composition for relieving convulsion, soothing the nerves, removing blood stasis, stopping bleeding, promoting diuresis and treating stranguria; the lung qi failing to disperse, the qi failing to distribute the body fluid and the function of regulating the flow of qi failing to regulate the water passage and the bladder failing to descend, so the recipe treats upper part of the disease with the root of balloonflower, opens the lung qi and lifts the kettle to uncover the cover; the ' Bie Ji ' indicates that tuckahoe is used for opening the chest, regulating the viscera and the qi and reducing the kidney evil ', so tuckahoe is used for strengthening the spleen, promoting diuresis and removing dampness, calming the heart and tranquilizing the mind and assisting in middle energizer qi transformation; cinnamon, cortex Cinnamomi, with effects of invigorating fire and yang, inducing fire to return to the source, and promoting lower jiao qi; radix Platycodi, poria and cortex Cinnamomi are used for regulating triple energizer and promoting bladder qi transformation. Materia medica Hui Yan: pollen Typhae enters liver meridian, is cool and beneficial, and can clean the original bladder, clear the qi of small intestine, stop bleeding, remove blood stasis and treat stranguria; radix Platycodi, poria, cortex Cinnamomi and pollen Typhae are all ministerial drugs. Spora Lygodii has effects of clearing away damp-heat, treating stranguria and relieving pain; the crinis Carbonisatus has the effects of astringing and stopping bleeding, removing blood stasis and promoting urination; talc has the effects of inducing diuresis for treating stranguria, eliminating dampness and healing sore. Radix paeoniae rubra has effects of clearing heat and cooling blood, removing blood stasis and relieving pain, and mixing with radix glycyrrhizae tip to harmonize liver and spleen, and relieving spasm and pain; the borneol has the effects of inducing resuscitation and refreshing mind, clearing heat and relieving pain, dredging orifices, dispelling stagnated fire, helping medical efficacy and transdermal permeability, thereby better playing the medical effect; the licorice root tip can purge fire and detoxify, induce diuresis and treat stranguria, and direct medicine to the affected part.

The invention is specially designed for postoperative damp-heat stasis type urination inconvenience, and the medicinal composition has proper compatibility of all medicinal herbs, plays a synergistic effect together, and has good effects of regulating viscera, promoting diuresis, removing blood stasis, stopping bleeding, promoting diuresis and treating stranguria. Meanwhile, the raw materials of the pharmaceutical composition do not relate to expensive medicinal materials, and the pharmaceutical composition is simple in preparation, low in cost, convenient to use and good in application prospect.

It should be apparent that, in light of the foregoing, various modifications, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.

The above-described aspects of the present invention will be described in further detail below with reference to specific embodiments in the form of examples. It should not be understood that the scope of the above subject matter of the present invention is limited to the following examples only. All techniques implemented based on the above description of the invention are within the scope of the invention.

Detailed Description

EXAMPLE 1 preparation of the medicament of the invention

The formula comprises the following components: 45g of amber, 20g of platycodon grandiflorum, 30g of poria cocos, 15g of cinnamon, 30g of pollen typhae, 30g of climbing fern spore, 30g of crinis Carbonisatus, 20g of talcum, 20g of red paeony root, 10g of borneol and 10g of licorice root tip.

The preparation method comprises the following steps: weighing the medicinal materials according to the proportion, mixing uniformly, pulverizing into powder, sieving with 120 mesh sieve, adding sesame oil, concocting into paste, making into 15x15cm medicinal cake with thickness of 0.5cm, and attaching on sterile dressing to obtain medicinal patch.

The using method comprises the following steps: the medicine is applied to the projection area of the lower abdomen bladder surface of the patient within 1 hour after the operation or when the urination after the operation is unfavorable, the medicine is reserved for 6-8 hours, the operation is feasible for the 2 nd time after the interval of 2 hours, and the medicine can be simultaneously applied to the application to place warm babies and carry out TDP irradiation, moxibustion or be matched with a traditional Chinese medicine directional drug-penetrating therapeutic apparatus for use.

EXAMPLE 2 preparation of the medicament of the invention

The formula comprises the following components: 30g of amber, 15g of platycodon grandiflorum, 20g of poria cocos, 10g of cinnamon, 25g of pollen typhae, 25g of climbing fern spore, 25g of crinis Carbonisatus, 15g of talcum, 15g of red paeony root, 8g of borneol and 8g of licorice root tip.

The preparation method and the application method are the same as the above

EXAMPLE 3 preparation of the medicament of the invention

The formula comprises the following components: 25g of amber, 10g of platycodon grandiflorum, 15g of poria cocos, 8g of cinnamon, 20g of pollen typhae, 20g of climbing fern spore, 20g of crinis carbonisatus, 10g of talcum, 10g of red paeony root, 5g of borneol and 5g of licorice root tip.

The preparation method and the application method are the same as the above

The advantageous effects of the present invention are described below by way of test examples.

Test example 1

1. Clinical data

The patients with difficult urination after mixed hemorrhoids operation in 2017 to 2021 and 12 of traditional Chinese medicine hospitals in south-charge city are selected and identified as damp-heat stasis. The method comprises the following steps of randomly dividing the hospital admission sequence into a test group 1, a test group 2, a test group 3, a control group 1, a control group 2 and a control group 3. Each group of 20 cases adopts the external peeling and internal pricking sclerosant injection of mixed hemorrhoids, the operation doctors are the same person, and the anesthesia mode is the anesthesia of the waist-back points.

In test group 1, 11 men and 9 women, aged 21-65 years, 3 cases of mild patients, 7 cases of moderate patients and 10 cases of severe patients; in test group 2, men 12, women 8, ages 20-67, mild cases, moderate cases, 7 cases, and severe cases were 9 cases; in test group 3, 10 men and 10 women, aged 19-68 years, 2 cases with mild disease, 7 cases with moderate disease, and 11 cases with severe disease; in the control group 1, men and women are 12, 8, the ages of 20-65, 3 cases of mild patients, 6 cases of moderate patients and 11 cases of severe patients; in the control group 2, 9 men and 11 women, the ages of 21-69 years, 2 cases of mild patients, 8 cases of moderate patients and 10 cases of severe patients; in the control group 3 (western medicine control group), 10 men and 10 women, the ages of 20-64 years, 4 cases of mild patients, 7 cases of moderate patients and 9 cases of severe patients are treated; the test group and the control group cases are compared in terms of gender, age, diagnosis, anesthesia mode, operation method and disease state, and the difference has no statistical significance (P is more than 0.05) and has comparability.

2. The diagnosis standard refers to the traditional Chinese medicine disease diagnosis curative effect standard issued by the national traditional Chinese medicine administration. Slight postoperative dribbling of urine, frequent urination; and (3) moderately: dropping urine after operation with lower abdomen distention discomfort; severe: the postoperative urination is completely blocked, with abdominal distention and pain.

3. Therapeutic method

Test group: the medicines prepared in the embodiments 1 to 3 of the invention are respectively applied to the lower abdomen bladder body surface projection area of the patient when urination is unfavorable after operation, and meanwhile, a warm baby is placed on the application and is kept for 8 hours; specific test group 1 used the drug application of example 1; test group 2 used the drug application of example 2; test group 3 used the drug application of example 3.

Control group 1: the raw material formula comprises 20g of platycodon grandiflorum, 30g of poria cocos, 30g of cattail pollen, 30g of climbing fern spore, 20g of talcum and 10g of borneol. Taking the raw material formula, uniformly mixing, pulverizing into powder, making into medicine, applying the medicine to a projection area of the lower abdomen bladder body surface of a patient when urination is unfavorable after operation, and simultaneously placing a warm baby on the application, and keeping for 8 hours.

Control group 2: the raw material formula comprises 20g of platycodon grandiflorum, 30g of poria cocos, 30g of pollen typhae, 30g of climbing fern spore, 30g of crinis Carbonisatus, 20g of talcum, 10g of borneol and 10g of licorice root tip. Taking the raw material formula, uniformly mixing, pulverizing into powder, making into medicine, applying the medicine to a projection area of the lower abdomen bladder body surface of a patient when urination is unfavorable after operation, and simultaneously placing a warm baby on the application, and keeping for 8 hours.

Control group 3 (western control group) was injected intramuscularly with 0.5mg of neostigmine injection from the gluteus maximus on one side when urination was induced to be ineffective after surgery.

4. Standard of efficacy

According to the traditional Chinese medicine disease diagnosis and treatment effect standard issued by the national traditional Chinese medicine administration.

And (3) curing: urine is automatically discharged within 2 hours after the medicine is taken; the method is effective: the urine can be discharged automatically but the urine discharge condition is improved by more than 2 hours or more than before the medicine is used; invalidation: the urine discharge condition is not improved compared with the prior medicament.

Total effective rate= (cure number + effective number)/total number x 100%.

5. Results

5.1 comparison of clinical efficacy is shown in Table 1.

Table 1 comparison of clinical efficacy

5.2 adverse reaction Rate comparison

Control group 3 had 1 drug eruption, 1 nausea, 1 vomiting. No significant adverse effects were seen in the remaining treatment and control groups.

The test results show that: the pharmaceutical composition has good relieving effect on clinical symptoms and physical signs of postoperative dysuria, can effectively treat postoperative dysuria, and is safe to use. Wherein the drug substance formulation of example 1 has the best effect.

In conclusion, the medicinal composition has proper compatibility of all medicinal herbs, plays a synergistic effect together, and has good effects of regulating viscera, promoting diuresis, removing blood stasis, stopping bleeding, promoting diuresis and treating stranguria. Aiming at the adverse urination after operation, the traditional Chinese medicine has good clinical curative effect and safe use. Meanwhile, the raw materials of the pharmaceutical composition do not relate to expensive medicinal materials, and the pharmaceutical composition is simple in preparation, low in cost, convenient to use and good in application prospect.

Claims

1. A pharmaceutical composition for treating postoperative dysuria, which is characterized in that: the composite material is prepared from the following raw materials in parts by weight:

2. The pharmaceutical composition according to claim 1, wherein: the composite material is prepared from the following raw materials in parts by weight:

3. The pharmaceutical composition according to claim 2, wherein: the composite material is prepared from the following raw materials in parts by weight:

4. A pharmaceutical composition according to any one of claims 1 to 3, characterized in that: the preparation is prepared by taking medicinal powder of the raw materials or water or organic solvent extracts of the raw materials as active ingredients and adding pharmaceutically acceptable auxiliary materials.

5. The pharmaceutical composition according to claim 4, wherein: the preparation is an external preparation.

6. The pharmaceutical composition according to claim 5, wherein: the external preparation is emplastrum, solution or aerosol.

7. The pharmaceutical composition according to claim 6, wherein: the emplastrum is a medicine emplastrum which is stuck to a lower abdomen bladder body surface projection area.

8. The method for preparing the pharmaceutical composition according to any one of claims 1 to 7, characterized in that: it comprises the following steps:

(1) Weighing the raw materials according to the proportion;

(2) Grinding the raw materials into powder, or preparing into water or organic solvent extractive solution, and adding adjuvants or auxiliary components commonly used in medicine.

9. Use of the pharmaceutical composition according to any one of claims 1 to 7 for the preparation of a medicament for post-operative dysuria.

10. Use according to claim 9, characterized in that: the medicine is used for treating damp-heat stasis type postoperative dysuria.