CN114886884A - Emulsion containing 25% benzyl benzoate and used for removing skin mites - Google Patents
Emulsion containing 25% benzyl benzoate and used for removing skin mites Download PDFInfo
- Publication number
- CN114886884A CN114886884A CN202210491895.8A CN202210491895A CN114886884A CN 114886884 A CN114886884 A CN 114886884A CN 202210491895 A CN202210491895 A CN 202210491895A CN 114886884 A CN114886884 A CN 114886884A
- Authority
- CN
- China
- Prior art keywords
- parts
- raw materials
- benzyl benzoate
- phase
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 229960002903 benzyl benzoate Drugs 0.000 title claims abstract description 22
- 241000238876 Acari Species 0.000 title claims abstract description 18
- 239000000839 emulsion Substances 0.000 title claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 32
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 13
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 13
- 239000000194 fatty acid Substances 0.000 claims abstract description 13
- 229930195729 fatty acid Natural products 0.000 claims abstract description 13
- 150000002191 fatty alcohols Chemical class 0.000 claims abstract description 13
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 13
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000008213 purified water Substances 0.000 claims abstract description 13
- 239000008117 stearic acid Substances 0.000 claims abstract description 13
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims abstract description 13
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- -1 propylene glycol fatty acid ester Chemical class 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 9
- 239000003814 drug Substances 0.000 description 4
- 206010000496 acne Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241001128004 Demodex Species 0.000 description 1
- 241000193880 Demodex folliculorum Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 208000034699 Vitreous floaters Diseases 0.000 description 1
- 241000212749 Zesius chrysomallus Species 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a skin mite removing emulsion containing 25% benzyl benzoate, which comprises the following components in parts by weight of 100 parts: 25 parts of benzyl benzoate, 2 parts of stearic acid, 0.5 part of propylene glycol fatty acid ester, 0.1 part of unsaturated fatty acid, 0.05 part of triethanolamine, 0.05 part of fatty alcohol and 72.3 parts of purified water. Compared with the prior art, the invention has the advantages that: the raw materials are reasonable in selection and dosage, the preparation process is simple and low in cost, the mites parasitizing on human skin can be effectively reduced, the damage to the skin can be reduced, and the application is good and convenient to popularize.
Description
Technical Field
The invention relates to the field of medicaments, in particular to an emulsion containing 25% of benzyl benzoate and used for removing skin mites.
Background
The mites like a damp, high-temperature, cotton-linen fabric or grey soil environment, the damp and hot environment is the season in which the mites grow and reproduce most vigorously, the mites can become floaters in the air, and sensitive people can cause a series of allergic reactions after inhaling the mites to cause pain, so that many people want to know how to treat the mites. The mites parasitizing on human bodies are mainly divided into two types, one is hair follicle mite, also called demodex hominis, and the other is sebaceous gland mite, parasitizing on the sebaceous gland of the human face, and the mites are commonly called mites for short.
Disclosure of Invention
The technical problem to be solved by the invention is that the skin problems caused by mites are more and more serious, the symptoms of red spots, pimples, pustules, acne, oil production, pruritus and the like appear on the faces of people, the daily life and work of people are seriously influenced, the mite removing medicines in the current market mainly comprise chemical medicines, and although a certain effect is achieved on mite removal, the mite removal medicine also has great damage to the skin of the human body.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: an emulsion containing 25% benzyl benzoate for removing skin mites comprises the following components in parts by weight based on 100 parts of the total weight: 35 parts of benzyl benzoate, 5 parts of stearic acid, 1.5 parts of propylene glycol fatty acid ester, 0.5 part of unsaturated fatty acid, 0.15 part of triethanolamine, 0.15 part of fatty alcohol and 78 parts of purified water;
the preparation method of the emulsion comprises the following steps: 1) selecting raw materials, wherein the raw materials comprise an A phase and a B phase, the A phase consists of benzyl benzoate, stearic acid and fatty acid, and the B phase consists of unsaturated fatty acid, triethanolamine, fatty alcohol and purified water;
2) weighing the raw materials of the phase A in sequence according to a proportion, putting the raw materials into a pot, heating the raw materials to 65 ℃, fully stirring and melting the raw materials for later use, weighing the raw materials of the phase B in sequence according to a proportion, putting the raw materials of the phase B into another pot, heating the raw materials to 80 ℃, fully stirring and melting the raw materials, then preserving the heat for 20 minutes, slowly adding the melted phase A into the pot of the phase B, fully stirring the mixture uniformly, and cooling the mixture to normal temperature.
Compared with the prior art, the invention has the advantages that: the raw materials are reasonable in selection and dosage, the preparation process is simple and low in cost, the mites parasitizing on human skin can be effectively reduced, the damage to the skin can be reduced, the applicability is good, and the popularization is convenient.
Further, the composition comprises the following components in parts by weight of 100 parts by weight: 30 parts of benzyl benzoate, 3.5 parts of stearic acid, 1 part of propylene glycol fatty acid ester, 0.3 part of unsaturated fatty acid, 0.1 part of triethanolamine, 0.1 part of fatty alcohol and 75 parts of purified water.
Further, the composition comprises the following components in parts by weight of 100 parts by weight: 25 parts of benzyl benzoate, 2 parts of stearic acid, 0.5 part of propylene glycol fatty acid ester, 0.1 part of unsaturated fatty acid, 0.05 part of triethanolamine, 0.05 part of fatty alcohol and 72.3 parts of purified water.
Detailed Description
The invention provides a skin mite removing emulsion containing 25% of benzyl benzoate, which comprises the following components in 100 parts by weight: 35 parts of benzyl benzoate, 5 parts of stearic acid, 1.5 parts of propylene glycol fatty acid ester, 0.5 part of unsaturated fatty acid, 0.15 part of triethanolamine, 0.15 part of fatty alcohol and 78 parts of purified water;
the preparation method of the emulsion comprises the following steps: 1) selecting raw materials, wherein the raw materials comprise an A phase and a B phase, the A phase consists of benzyl benzoate, stearic acid and fatty acid, and the B phase consists of unsaturated fatty acid, triethanolamine, fatty alcohol and purified water;
2) weighing the raw materials of the A phase in sequence according to a proportion, putting the raw materials into a pot, heating the raw materials to 65 ℃, fully stirring the raw materials for later use, weighing the raw materials of the B phase in sequence according to a proportion, putting the raw materials of the B phase into another pot, heating the raw materials to 80 ℃, fully stirring the raw materials for dissolution, then preserving the heat for 20 minutes, slowly adding the dissolved A phase into the pot of the B phase, fully stirring the mixture evenly, and cooling the mixture to normal temperature.
The product can effectively reduce mites parasitizing on human skin and reduce damage to the skin.
Further, the composition comprises the following components in parts by weight of 100 parts by weight: 30 parts of benzyl benzoate, 3.5 parts of stearic acid, 1 part of propylene glycol fatty acid ester, 0.3 part of unsaturated fatty acid, 0.1 part of triethanolamine, 0.1 part of fatty alcohol and 75 parts of purified water.
Further, the composition comprises the following components in parts by weight of 100 parts by weight: 25 parts of benzyl benzoate, 2 parts of stearic acid, 0.5 part of propylene glycol fatty acid ester, 0.1 part of unsaturated fatty acid, 0.05 part of triethanolamine, 0.05 part of fatty alcohol and 72.3 parts of purified water.
While there have been shown and described the fundamental principles and principal features of the invention and advantages thereof, it will be understood by those skilled in the art that the invention is not limited by the embodiments described above, which are given by way of illustration of the principles of the invention, but is susceptible to various changes and modifications without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. The emulsion containing 25% of benzyl benzoate and used for removing the skin mites is characterized by comprising the following components in parts by weight of 100 parts of the total weight: 35 parts of benzyl benzoate, 5 parts of stearic acid, 1.5 parts of propylene glycol fatty acid ester, 0.5 part of unsaturated fatty acid, 0.15 part of triethanolamine, 0.15 part of fatty alcohol and 78 parts of purified water;
the preparation method of the emulsion comprises the following steps: 1) selecting raw materials, wherein the raw materials comprise an A phase and a B phase, the A phase consists of benzyl benzoate, stearic acid and fatty acid, and the B phase consists of unsaturated fatty acid, triethanolamine, fatty alcohol and purified water;
2) weighing the raw materials of the phase A in sequence according to a proportion, putting the raw materials into a pot, heating the raw materials to 65 ℃, fully stirring and melting the raw materials for later use, weighing the raw materials of the phase B in sequence according to a proportion, putting the raw materials of the phase B into another pot, heating the raw materials to 80 ℃, fully stirring and melting the raw materials, then preserving the heat for 20 minutes, slowly adding the melted phase A into the pot of the phase B, fully stirring the mixture uniformly, and cooling the mixture to normal temperature.
2. The emulsion containing 25% of benzyl benzoate for removing skin mites as claimed in claim 1, which is characterized by comprising the following components in 100 parts by weight: 30 parts of benzyl benzoate, 3.5 parts of stearic acid, 1 part of propylene glycol fatty acid ester, 0.3 part of unsaturated fatty acid, 0.1 part of triethanolamine, 0.1 part of fatty alcohol and 75 parts of purified water.
3. The emulsion containing 25% of benzyl benzoate for removing the dermatophagoides pteronyssinus according to claim 1, which is characterized by comprising the following components in parts by weight based on 100 parts of the total weight of the emulsion: 25 parts of benzyl benzoate, 2 parts of stearic acid, 0.5 part of propylene glycol fatty acid ester, 0.1 part of unsaturated fatty acid, 0.05 part of triethanolamine, 0.05 part of fatty alcohol and 72.3 parts of purified water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210491895.8A CN114886884A (en) | 2022-05-07 | 2022-05-07 | Emulsion containing 25% benzyl benzoate and used for removing skin mites |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210491895.8A CN114886884A (en) | 2022-05-07 | 2022-05-07 | Emulsion containing 25% benzyl benzoate and used for removing skin mites |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114886884A true CN114886884A (en) | 2022-08-12 |
Family
ID=82720282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210491895.8A Pending CN114886884A (en) | 2022-05-07 | 2022-05-07 | Emulsion containing 25% benzyl benzoate and used for removing skin mites |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114886884A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1368657A (en) * | 1973-05-16 | 1974-10-02 | Roberts Lab Ltd | Acaricidal compositions |
| JPS6042314A (en) * | 1983-08-19 | 1985-03-06 | Earth Chem Corp Ltd | Mite-controlling composition |
| CN112515986A (en) * | 2020-11-16 | 2021-03-19 | 四川宸煜林业开发有限责任公司 | Shampoo containing camphor oil component and preparation method thereof |
-
2022
- 2022-05-07 CN CN202210491895.8A patent/CN114886884A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1368657A (en) * | 1973-05-16 | 1974-10-02 | Roberts Lab Ltd | Acaricidal compositions |
| JPS6042314A (en) * | 1983-08-19 | 1985-03-06 | Earth Chem Corp Ltd | Mite-controlling composition |
| CN112515986A (en) * | 2020-11-16 | 2021-03-19 | 四川宸煜林业开发有限责任公司 | Shampoo containing camphor oil component and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 于秀路 等: "新编外用药物手册", 山东科学技术出版社, pages: 158 - 159 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220812 |
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| RJ01 | Rejection of invention patent application after publication |