CN114886786B - Elastic liposome composition and preparation method and application thereof - Google Patents
Elastic liposome composition and preparation method and application thereof Download PDFInfo
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- CN114886786B CN114886786B CN202210577130.6A CN202210577130A CN114886786B CN 114886786 B CN114886786 B CN 114886786B CN 202210577130 A CN202210577130 A CN 202210577130A CN 114886786 B CN114886786 B CN 114886786B
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- elastic liposome
- liposome composition
- water
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- 239000002502 liposome Substances 0.000 title claims abstract description 93
- 239000000203 mixture Substances 0.000 title claims abstract description 76
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 150000002632 lipids Chemical class 0.000 claims abstract description 27
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 27
- 239000002537 cosmetic Substances 0.000 claims abstract description 21
- 150000002148 esters Chemical class 0.000 claims abstract description 21
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 20
- 239000000787 lecithin Substances 0.000 claims abstract description 17
- 229940067606 lecithin Drugs 0.000 claims abstract description 17
- 235000010445 lecithin Nutrition 0.000 claims abstract description 17
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000008117 stearic acid Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000005886 esterification reaction Methods 0.000 claims abstract description 6
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 41
- 235000005152 nicotinamide Nutrition 0.000 claims description 26
- 239000011570 nicotinamide Substances 0.000 claims description 26
- 229960003966 nicotinamide Drugs 0.000 claims description 26
- 229920005862 polyol Polymers 0.000 claims description 21
- 150000003077 polyols Chemical class 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 239000012071 phase Substances 0.000 claims description 8
- 239000008346 aqueous phase Substances 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 claims description 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 229940113120 dipropylene glycol Drugs 0.000 claims description 2
- 229940100573 methylpropanediol Drugs 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 abstract description 8
- 150000005846 sugar alcohols Polymers 0.000 abstract description 5
- 230000007794 irritation Effects 0.000 abstract description 4
- 231100000245 skin permeability Toxicity 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 28
- 230000000694 effects Effects 0.000 description 16
- 239000011248 coating agent Substances 0.000 description 13
- 238000000576 coating method Methods 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 13
- 210000000434 stratum corneum Anatomy 0.000 description 12
- 206010040829 Skin discolouration Diseases 0.000 description 8
- 239000006071 cream Substances 0.000 description 7
- 230000035515 penetration Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 239000012528 membrane Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000002738 chelating agent Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- 229940082500 cetostearyl alcohol Drugs 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 3
- 238000011056 performance test Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical group CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011449 brick Substances 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 229940106189 ceramide Drugs 0.000 description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001246 colloidal dispersion Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000011258 core-shell material Substances 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 230000009975 flexible effect Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000003580 lung surfactant Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- -1 softeners Substances 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 229950011392 sorbitan stearate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Abstract
The invention discloses an elastic liposome composition, a preparation method and application thereof, wherein the raw materials of the elastic liposome composition comprise a water phase component, a polyalcohol component and a lipid component; the water phase component comprises water and water-soluble active ingredients, the lipid component consists of lecithin and polyglycerol ester with the mass ratio of 1:0.01-0.3, the polyglycerol ester is obtained by esterification reaction of polyglycerol and stearic acid, the lipid component forms a phospholipid layer in the elastic liposome composition, the phospholipid layer coats the water-soluble active ingredients and forms an elastic liposome, and the water-soluble active ingredients account for 0.0001-10.0% by mass percent; the elastic liposome composition can be directly used or applied to cosmetics, can improve the skin permeability of water-soluble active ingredients, and has almost no irritation to skin.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to an elastic liposome composition, and a preparation method and application thereof.
Background
In general, cosmetics refer to chemical industry or fine chemical products that are spread on any part of the surface of the human body, such as skin, hair, nails, lips, teeth, etc., by painting, spraying, or the like, to achieve cleaning, maintenance, beauty, modification, and change of appearance, or to correct odor of the human body, and to maintain a good state.
At present, common cosmetics with the effects of whitening, anti-wrinkle, antioxidation, anti-aging and the like generally act on a human body through skin, and then are absorbed into the interior through skin, so that the corresponding effects are exerted. The skin is divided into 3 parts, namely a stratum corneum, an epidermis layer and a dermis layer, wherein the stratum corneum is positioned at the outermost layer of the skin, keratinocytes taking keratin as a main component form a layered structure in the stratum corneum, the adjacent keratinocytes are filled with intercellular lipid, and the whole structure is similar to Brick and mortar (Brick and cement); meanwhile, unlike other biofilms composed of phospholipids, the stratum corneum is composed of lipid components such as Ceramide (Ceramide), cholesterol (Cholesterol), free fatty acids (Free fatty acids), and the like, which are connected in a straight line, so that the fat-soluble active ingredients are easily absorbed, but there is a problem that moisture and water-soluble active ingredients are more difficult to permeate the stratum corneum.
For example, niacinamide (Niacinamide), which is one of raw materials of anti-aging and whitening components, is a water-soluble vitamin B3, which is also known as Niacinamide, among vitamin B groups, and is known to have excellent moisturizing and whitening effects, but it has been studied that, since it is a water-soluble component, only a small amount of Niacinamide is simply formulated into cosmetics, there is a case where there is no significant effect, and in order to improve the effect, it is a general method to increase the amount of addition, however, there is a problem that there is a relatively significant irritation to the skin when it is added in a high content.
Therefore, how to overcome the skin barrier and thereby increase the penetration efficiency of water and water-soluble active ingredients in intercellular lipids is a technical problem to be solved in the art.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a novel elastic liposome composition which can improve the skin permeability of water-soluble active ingredients and has little irritation to skin.
The invention also provides a novel elastic liposome.
The invention also provides a preparation method of the elastic liposome composition.
The invention also provides a cosmetic composition containing the elastic liposome composition.
In order to achieve the above purpose, the invention adopts a technical scheme that:
an elastic liposome composition, which comprises the following raw materials: an aqueous phase component, a polyol component and a lipid component;
wherein the aqueous phase component comprises water, a water-soluble active ingredient;
the lipid component consists of lecithin and polyglycerol ester, wherein the mass ratio of the lecithin to the polyglycerol ester is 1:0.01-0.3, and the polyglycerol ester is obtained through esterification reaction of polyglycerol and stearic acid;
in the elastic liposome composition, the lipid component forms a phospholipid layer which coats the water-soluble active ingredient and forms an elastic liposome, and the water-soluble active ingredient accounts for 0.0001-10.0% by mass percent.
According to some preferred aspects of the invention, the ratio of the lipid component to the water-soluble active ingredient is 1:0.0001-2.5 by mass. Further, the mass ratio of the lipid component to the water-soluble active ingredient is 1:0.1-2.5.
In some embodiments of the invention, the ratio of the lipid component to the water-soluble active ingredient is 1:0.5-2.5 by mass.
According to some preferred aspects of the present invention, in the process of preparing the polyglycerol ester, the molar amount of stearic acid added is equal to or greater than the molar amount of the polyglycerol added, and for example, may be an equimolar amount reaction, may be that the molar amount of stearic acid added is 2 times the molar amount of the polyglycerol added, or the like; in some preferred and specific embodiments of the present invention, the polyglycerol ester may be polyglycerol-10 stearate and/or polyglycerol-10 distearate.
According to the present invention, lecithin is a yellow brown oily substance present in animal and plant tissues and yolk, and the constituent components include phosphoric acid, choline, fatty acid, glycerol, glycolipid, triglyceride and phospholipid, and are important constituent components of cell membranes, alveolar surfactant, lipoprotein and bile. Practice shows that the lecithin is compounded with the polyglycerol ester, so that the elasticity, softness and deformability of the elastic liposome can be improved, the elastic liposome is beneficial to passing through the stratum corneum, and finally the effect of conveying the effective components more efficiently can be achieved. In some preferred and specific embodiments of the present invention, the lecithin may be hydrogenated lecithin.
In the present invention, if the elastic liposome composition of the present invention is not prepared according to the weight percentage of lecithin to polyglycerol ester of 1:0.01 to 0.3, the softness, elasticity, deformability and coating efficiency of the water-soluble active ingredient of the elastic liposome are all significantly reduced. In some preferred and specific embodiments of the present invention, the mass ratio of the lecithin to the polyglycerol ester is 1:0.01-0.15. According to a specific aspect of the invention, the mass ratio of the lecithin to the polyglycerol ester is 1:0.025.
According to some preferred aspects of the invention, the water-soluble active ingredient includes, but is not limited to, niacinamide, but may be other water-soluble active ingredients.
According to some preferred and specific aspects of the present invention, the water-soluble active ingredient is niacinamide, and the niacinamide is 0.1% -10.0% in the elastic liposome composition. In some embodiments of the invention, the nicotinamide comprises 1% to 10.0% by mass of the elastic liposome composition.
According to some preferred aspects of the invention, the polyol component comprises 1% to 20% by mass of the elastic liposome composition.
According to some preferred aspects of the invention, the polyol component is a combination of one or more selected from glycerol, butanediol, 1, 3-propanediol, 1, 2-hexanediol, methylpropanediol, dipropylene glycol.
According to the invention, the elastic liposomes have an average particle size of 70-200nm.
In the present invention, the elastic liposome composition of the present invention may further comprise other additives, including, for example, but not limited to, moisturizers, preservatives, pH regulators, skin conditioners, and the like.
In some embodiments of the invention, the water in the elastic liposome composition can be deionized water.
The invention provides another technical scheme that: the preparation method of the elastic liposome composition comprises the following steps:
(1) Mixing and dispersing the components in the water phase component, and heating to 72-85 ℃;
(2) Mixing and dispersing the components in the polyol component, and heating to 72-85 ℃;
(3) Adding the lipid component into the polyol component treated in the step (2), and uniformly mixing;
(4) Adding the mixture obtained after the treatment in the step (3) into the water phase component obtained after the treatment in the step (1) under the stirring condition, and uniformly mixing;
(5) Cooling the mixture obtained after the treatment in the step (4) to 50-65 ℃, and homogenizing after cooling to prepare the elastic liposome composition.
According to the invention, the step (1) and the step (2) are not sequential.
According to some preferred aspects of the invention, in step (1) and step (2), heating is carried out to 75-82 ℃ respectively, and further heating is carried out to 78-80 ℃ respectively.
According to some preferred aspects of the invention, in step (5), cooling is carried out to 55-62 ℃.
In some embodiments of the invention, the homogenization treatment is performed using a dynamic ultra-high pressure homogenizer.
In some embodiments of the invention, the homogenization treatment may be performed multiple times, for example, 2 times, 3 times, or even more.
According to the present invention, in the elastic liposome composition, the formed elastic liposome is dispersed in a mixed system composed of water and a polyol component or the like.
The invention provides another technical scheme that: an elastic liposome in the above elastic liposome composition.
In the present invention, the elastic liposome may not contain water and a polyol component, but may be actually prepared with a small amount of water and polyol mixed therein.
In the present invention, the elastic liposome composition may be used directly on the skin, or may be used as one of the raw materials to prepare a cosmetic composition for use on the skin.
Further, the invention provides another technical scheme: a cosmetic composition comprising, in mass%, 0.0001% to 50% of the above-described elastic liposome composition.
The cosmetic composition of the present invention may contain, in addition to the above-mentioned elastic liposome composition, one or more components selected from the group consisting of moisturizers, solvents, thickeners, lipids, dissolving agents, concentrates, gelling agents, softeners, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, emulsifiers, fillers, chelating agents, preservatives, vitamins, blocking agents, humectants, oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles, and the balance water.
The cosmetic composition of the present invention may be in the form of one of a toner, astringent, essence, emulsion, essence cream, essence, ampoule, face cream, eye cream, massage cream, mask, foundation, BB cream, pre-make-up cream, powder, sun cream, cleansing lotion, shampoo, conditioner, scalp essence, body cream, shower gel, body spray, but is not limited thereto.
In some embodiments of the invention, the cosmetic composition comprises a first component comprising water, a polyol, a chelating agent, an elastic liposome composition as described above, a thickening agent, and a second component comprising cetostearyl alcohol, polyglycerol-10 distearate, caprylic/capric triglyceride.
In some embodiments of the present invention, the polyol may be glycerin, 1, 2-hexanediol, etc., and the polyol may be 2% -15% by mass.
In some embodiments of the present invention, the chelating agent may be disodium ethylenediamine tetraacetate (EDTA-2 Na), and the chelating agent may be 0.001% -1% by mass.
In some embodiments of the present invention, the thickener may be an ammonium acryloyldimethyl taurate/VP copolymer, which is mainly used for thickening, rheological property and pleasant feeling after use, and is 0.05% -3% by mass.
In some embodiments of the present invention, the cosmetic composition comprises, in mass percent, 5% to 20% of the second component.
In some embodiments of the present invention, the water (which may be deionized water) in the first component may be used to make up the remaining content after the other component content is determined, based on 100% content in the cosmetic composition.
In some embodiments of the invention, the second component comprises the cetostearyl alcohol, the polyglycerol-10 distearate, and the caprylic/capric triglyceride in a mass ratio of 1:2 to 3:2 to 3.
In some embodiments of the invention, the cosmetic composition is prepared by the following method:
(1) Mixing and dispersing the first component uniformly, and heating to 70-80 ℃;
(2) Uniformly mixing the second component, heating to 70-80 ℃ and completely dissolving;
(3) Pouring the second component treated in the step (2) into the first component treated in the step (1), homogenizing and emulsifying in vacuum at 70-80deg.C (2500-3500 rpm), cooling to 40-50deg.C, emulsifying again (2500-3500 rpm), and cooling to obtain cosmetic composition.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:
the invention is based on the problem that the water-soluble active ingredients are difficult to pass through the stratum corneum, so that the percutaneous absorption rate is low. Based on a large number of experiments, it is unexpectedly found that when lecithin and polyglycerol ester (obtained by esterification reaction of polyglycerol and stearic acid) are adopted and combined according to a specific proportion, the effect of coating water-soluble active ingredients can be achieved in a mixed system of water and polyalcohol, the coating rate is high, the coated stable state can be maintained for a long time, and finally, elastic liposome dispersed in the mixed system of water and polyalcohol is formed.
Drawings
FIG. 1 is a schematic diagram of the structure of an elastic liposome in an elastic liposome composition prepared according to an embodiment of the present invention;
FIG. 2 is a schematic diagram showing the process of penetration of elastic liposomes into the stratum corneum according to an embodiment of the present invention.
Detailed Description
The main conception of the invention is that: provided is a novel vesicle having soft and flexible properties, namely, an elastic liposome of the present invention, which has a similar core-shell structure as shown in FIG. 1, a phospholipid layer as an outer layer and a water-soluble active ingredient as an inner core, and the phospholipid layer has excellent deformability and flexibility, and is deformed to conform to the shape of the interstices of the stratum corneum when facing the stratum corneum in a state where the lamellar structure and the lipid ingredient are linearly connected, thereby realizing circulation, and is stable in overall structure and not liable to break when penetrating the stratum corneum, and is capable of recovering the original form after penetration, and a schematic diagram of penetration of the stratum corneum is shown in FIG. 2.
Further, based on the above-described conception, the present inventors have found that when lecithin and polyglyceryl ester (obtained by esterification reaction of polyglycerin with stearic acid) are used in combination in a specific ratio, it is possible to achieve the effect of coating a water-soluble active ingredient in a mixed system of water and polyhydric alcohol with a high coating ratio, and finally an elastic liposome dispersed in the mixed system of water and polyhydric alcohol is formed, which has not only excellent deformability and flexibility but also good stability during deformation, and substantially does not suffer from failure of coating effect.
Based on the above, the invention provides an elastic liposome composition, which comprises the following raw materials: an aqueous phase component, a polyol component and a lipid component;
wherein the aqueous phase component comprises water, a water-soluble active ingredient;
the lipid component consists of lecithin and polyglycerol ester, wherein the mass ratio of the lecithin to the polyglycerol ester is 1:0.01-0.3, and the polyglycerol ester is obtained through esterification reaction of polyglycerol and stearic acid;
in the elastic liposome composition, the lipid component forms a phospholipid layer which coats the water-soluble active ingredient and forms an elastic liposome, and the water-soluble active ingredient accounts for 0.0001-10.0% by mass percent.
The elastic liposome composition can improve the skin permeability of water-soluble active ingredients, has almost no irritation to skin, has relatively high coating rate, and can realize the maximization effect of low-concentration active substances; in addition, the raw materials used in the invention have no safety dispute, and can be applied to human skin.
The above-described aspects are further described below in conjunction with specific embodiments; it should be understood that these embodiments are provided to illustrate the basic principles, main features and advantages of the present invention, and that the present invention is not limited by the scope of the following embodiments; the implementation conditions employed in the examples may be further adjusted according to specific requirements, and the implementation conditions not specified are generally those in routine experiments.
All starting materials are commercially available or prepared by methods conventional in the art, not specifically described in the examples below.
Examples 1 to 3
The present examples provide elastomeric liposome compositions and methods of making the same, the materials and amounts of which are shown in table 1 below.
TABLE 1
Note that: hydrogenated lecithin was purchased from NEUROPID under the trademark SOYA-SPL 75H (PF); polyglycerol-10 stearate is available from NIPPON SURFACTANT INDUSTRIES co., LTD, brand decaglycon 1-SV; butanediol: butyl glycol.
The preparation method of the elastic liposome composition comprises the following steps:
(1) Mixing and dispersing the components in the water phase component, and heating to 78-80 ℃;
(2) Mixing and dispersing the components in the polyol component, and heating to 78-80 ℃;
(3) Adding the lipid component into the polyol component treated in the step (2), and uniformly mixing;
(4) Adding the mixture obtained after the treatment in the step (3) into the water phase component obtained after the treatment in the step (1) under the stirring condition, and uniformly mixing;
(5) Cooling the mixture obtained after the treatment in the step (4) to 60 ℃, and homogenizing for 2 times by using a dynamic ultrahigh pressure homogenizer (about 1300 bar) after cooling to prepare the elastic liposome composition.
Comparative example 1
Substantially the same as in example 1, the only difference is that: the mass percentage of nicotinamide is adjusted to 15%. The elastic liposome composition prepared in this example was directly applied to the skin with stimulus feedback.
Comparative example 2
Substantially the same as in example 1, the only difference is that: polyglycerol-10 stearate was replaced with sorbitan stearate (SPAN 60) in equal amounts.
Comparative example 3
Substantially the same as in example 1, the only difference is that: polyglycerol-10 stearate was replaced with sorbitan oleate (SPAN 80) in the same amount.
Performance test 1
The liposomes prepared in example 1 and comparative examples 2 to 3 were subjected to the following performance tests, and specific results are shown in Table 2.
The test method is as follows:
(1) Particle size and ZETA potential: microtrac Flex (Microtrac, USA) using the principle of scattering of light was used. The average particle size was shown by a cubic analysis and the degree of distribution, i.e., polydispersity index, was resolved by the CONTIN algorithm. The measurement conditions of the particle size and ZETA potential were as follows, temperature: 25 ℃, scattering angle: 165 °, light source: argon laser.
(2) Coating rate: a certain amount of the elastic liposomes of example 1 and comparative examples 2 and 3 was filtered out with 0.45 μm syringfilter (Minisart CA 26 mm, germany), the uncoated nicotinamide was removed by repeating the same procedure 3 times, 1mL of the liposome composition treated in the above-mentioned manner was mixed with 10mL of ethanol to break the lipid membrane of the elastic liposome, the solvent was evaporated by a rotary evaporator, the water bath temperature was maintained at about 35℃and 1mL of ethanol was further added, and the coated nicotinamide of the elastic liposome was quantitatively analyzed by UV-vis spectrometer. In addition, the concentration of nicotinamide coated in the elastic liposome is calculated by preparing standard curves with different concentrations, and the coating rate of the elastic liposome is calculated according to the formula 1;
coating ratio (%) = (T-P)/t×100;
t: initial nicotinamide concentration;
p: nicotinamide concentration that did not pass 0.45 μm syringfilter.
(3) Deformation index: the extent of penetration of the elastic liposomes in the artificial permeation barrier was determined using a mini extruder. Specifically, after the elastic liposome was pressurized at a pressure of 0.2MPa for 1 minute and 30 seconds, the amount of Polycarbonate membrane elastic liposome passing through 0.08 μ pore was measured, and the particle size of elastic liposome passing through the artificial permeation barrier was determined. At this time, the elasticity of the elastic liposome membrane is expressed as follows;
deformation index=j Flux ×(r v /r p ) 2 ；
J Flux : the amount of elastic liposomes by membrane;
r v : particle size of the elastic liposome after extrusion;
r p : pore size of membrane.
TABLE 2
Note that: polydispersity index: the ratio of the weight average molecular weight to the number average molecular weight characterizes a parameter of the molecular weight inhomogeneity of the polymer. The larger the number, the wider the molecular weight distribution of the liposome, and the more nonuniform the size.
ZETA potential: the important meaning of the ZETA potential is that its value is related to the stability of the colloidal dispersion. The ZETA potential is a measure of the strength of the mutual repulsion or attraction between particles. The smaller the molecule or dispersed particle, the higher the absolute value of the ZETA potential (positive or negative), the more stable the system, i.e., the dissolution or dispersion can resist aggregation.
Coating rate: refers to the ability of liposomes to encapsulate water-soluble active ingredients.
Deformation index: i.e. the elasticity index, the larger the number the greater the elasticity and the higher the deformability.
Examples 4 to 5 and comparative examples 4 to 6
The cosmetic compositions of examples 4 to 5 were obtained by preparing the cosmetic compositions of examples 1 to 2 above, and the elastic liposome compositions of comparative examples 4 to 6 were replaced with nicotinamide, respectively, based on example 4, in the amounts of 2%, 5%, 10% by weight, respectively, as shown in Table 3 below.
TABLE 3 Table 3
Note that: the ammonium acryloyldimethyl taurate/VP copolymer is available from CLARIANT under the trademark ARISTOFLEX AVC;
cetostearyl alcohol is available from BASF under the trademark
Polyglycerol-10 distearate was purchased from ILSHINWELLS under the trade designation ALMAX-9062;
caprylic/capric triglyceride is available from EVONIK under the trademark
The preparation method of the cosmetic composition comprises the following steps:
(1) Uniformly mixing and dispersing the first component, and heating to 75-78 ℃;
(2) Uniformly mixing the second component, heating to 75-78 ℃ and completely dissolving;
(3) Slowly pouring the second component of the treated step (2) into the first component of the treated step (1), homogenizing and emulsifying (3000 rpm) in vacuum at 75-78 ℃, cooling to 45 ℃, performing secondary emulsification (3000 rpm), and cooling to 35 ℃ to obtain the cosmetic composition.
Performance test (II)
The cosmetic compositions obtained in examples 4 to 5 and comparative examples 4 to 6 were evaluated for efficacy.
The testing method comprises the following steps: a Japanese American CM-2500D color difference meter [ KONICA MINOLTA ] was used. The values of L, a, b at each observation time point were measured for the test and control areas, respectively, and each area was tested 3 times and recorded. Calculating individual skin tone type angle (individule type angle, ITA °) parameters:
l: white chromaticity;
a: red chromaticity;
b: yellow chromaticity;
the greater the ITA DEG value, the lighter the skin tone, and conversely the darker the skin tone.
1. Skin whitening effect
The test part (face) stands for 30 minutes under the constant temperature and humidity environment;
determination of skin Brightness L before use, after 2 weeks of use, after 4 weeks of use * ；
According to the method of using the product, a proper amount of sample is taken and uniformly smeared on the face once in the morning and at night, and the sample is gently and completely absorbed.
Evaluation criteria: skin lightening improvement rate = (skin lightening after use-skin lightening before use)/skin lightening before use 100%.
The results are shown in Table 4 below.
TABLE 4 skin lightening L *
Test results: by data analysis, the skin lightening effect of examples 4 and 5, in which niacinamide was added after coating the elastic liposome of the present invention, was significantly increased compared to that of comparative examples 4 and 5, in which niacinamide was directly applied to dosage forms, in the case of adding the same amount of niacinamide. Illustrating that the elastic liposomes of the present invention help to increase the skin penetration of the water-soluble active ingredient.
The skin lightening effect of example 5 (total nicotinamide content 5%) in the present invention is not significantly different from that of comparative example 6 (total nicotinamide content 10%), but the addition ratio of nicotinamide may indicate that the inventive elastic liposome coated with a low concentration of active ingredient may achieve a similar effect as the high content of active ingredient.
2. Skin color improving effect
The test part (face) stands for 30 minutes under the constant temperature and humidity environment;
determining skin chromaticity ITA DEG before use, after use for 2 weeks and after use for 4 weeks;
according to the method of using the product, a proper amount of sample is taken and uniformly smeared on the face once in the morning and at night, and the sample is gently and completely absorbed.
Evaluation criteria: skin chromaticity improvement rate= (skin chromaticity after use-skin chromaticity before use)/skin chromaticity before use 100%.
The results are shown in Table 5 below.
TABLE 5 skin chromaticity ITA DEG
Test results: by data analysis, the skin tone improving effect of the example 4 and the example 5, in which the niacinamide is added after the coating of the elastic liposome of the present invention, is significantly increased compared with the skin tone improving effect of the comparative example 4 and the comparative example 5, in which the niacinamide is directly applied to the dosage form. Illustrating that the elastic liposomes of the present invention help to increase the skin penetration of the water-soluble active ingredient.
The skin lightening effect of example 5 (total nicotinamide content 5%) in the present invention is not significantly different from that of comparative example 6 (total nicotinamide content 10%), but the addition ratio of nicotinamide may indicate that the inventive elastic liposome coated with a low concentration of active ingredient may achieve a similar effect as the high content of active ingredient.
The above embodiments are provided to illustrate the technical concept and features of the present invention and are intended to enable those skilled in the art to understand the content of the present invention and implement the same, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made in accordance with the spirit of the present invention should be construed to be included in the scope of the present invention.
The endpoints and any values of the ranges disclosed herein are not limited to the precise range or value, and are understood to encompass values approaching those ranges or values. For numerical ranges, one or more new numerical ranges may be found between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point value, in combination with each other, and are to be considered as specifically disclosed herein.
Claims (9)
1. An elastic liposome composition is characterized in that the raw materials of the elastic liposome composition comprise the following components: an aqueous phase component, a polyol component and a lipid component;
wherein the aqueous phase component comprises water, a water-soluble active ingredient;
the lipid component consists of lecithin and polyglycerol ester, wherein the mass ratio of the lecithin to the polyglycerol ester is 1:0.01-0.3, and the polyglycerol ester is obtained through esterification reaction of polyglycerol and stearic acid; wherein the polyglycerol ester is polyglycerol-10 stearate and/or polyglycerol-10 distearate, and the lecithin is hydrogenated lecithin;
the water-soluble active ingredient comprises nicotinamide, wherein the nicotinamide accounts for 0.1-10.0% of the elastic liposome composition in percentage by mass;
the preparation method of the elastic liposome composition comprises the following steps:
(1) Mixing and dispersing the components in the water phase component, and heating to 72-85 ℃;
(2) Mixing and dispersing the components in the polyol component, and heating to 72-85 ℃;
(3) Adding the lipid component into the polyol component treated in the step (2), and uniformly mixing;
(4) Adding the mixture obtained after the treatment in the step (3) into the water phase component obtained after the treatment in the step (1) under the stirring condition, and uniformly mixing;
(5) Cooling the mixture obtained after the treatment in the step (4) to 50-65 ℃, and homogenizing after cooling to prepare the elastic liposome composition.
2. The elastic liposome composition according to claim 1, wherein the ratio of the lipid component to the water-soluble active ingredient is 1:0.0001-2.5 by mass.
3. The elastic liposome composition of claim 2, wherein the ratio of the lipid component to the water-soluble active ingredient is 1:0.1-2.5 by mass.
4. The elastic liposome composition of claim 1, wherein the mass ratio of lecithin to polyglycerol ester is 1:0.01-0.15.
5. The elastic liposome composition of claim 1, wherein the polyol component comprises 1% -20% by mass of the elastic liposome composition, and the polyol component is one or a combination of more selected from the group consisting of glycerin, butylene glycol, 1, 3-propanediol, 1, 2-hexanediol, methyl propanediol and dipropylene glycol.
6. The elastic liposome composition of claim 1, wherein the elastic liposome in the elastic liposome composition has an average particle size of 70-200nm.
7. A method of preparing the elastic liposome composition of any one of claims 1-6, comprising:
(1) Mixing and dispersing the components in the water phase component, and heating to 72-85 ℃;
(2) Mixing and dispersing the components in the polyol component, and heating to 72-85 ℃;
(3) Adding the lipid component into the polyol component treated in the step (2), and uniformly mixing;
(4) Adding the mixture obtained after the treatment in the step (3) into the water phase component obtained after the treatment in the step (1) under the stirring condition, and uniformly mixing;
(5) Cooling the mixture obtained after the treatment in the step (4) to 50-65 ℃, and homogenizing after cooling to prepare the elastic liposome composition.
8. An elastic liposome, wherein the elastic liposome is an elastic liposome in the elastic liposome composition of any one of claims 1 to 6.
9. A cosmetic composition comprising, in mass%, from 0.0001% to 50% of the elastic liposome composition of any one of claims 1 to 6.
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100043748A (en) * | 2008-10-21 | 2010-04-29 | (주)네오팜 | Elastic liposome and composition of skin external application containing the same |
| CN109700671A (en) * | 2018-02-13 | 2019-05-03 | 深圳高尚科美生物科技有限公司 | Flexible lipidosome cosmetics and preparation method thereof comprising active small molecular substance |
| CN111195230A (en) * | 2018-11-19 | 2020-05-26 | 奥维嘉生物科技（北京）有限公司 | Method for preparing flexible liposome |
| KR20200095244A (en) * | 2019-01-31 | 2020-08-10 | 서울과학기술대학교 산학협력단 | A deformable liposome prepared with natural surfactants and use of the same |
| KR20210095352A (en) * | 2020-01-23 | 2021-08-02 | (주)에이티 랩 | Manufacturing method of liposome with enhanced skin permeation |
| WO2021235767A1 (en) * | 2020-05-19 | 2021-11-25 | 주식회사 스타스테크 | Method for obtaining collagen peptide from starfish, elastic liposome comprising starfish-derived collagen peptide, and cosmetic composition comprising same |
| CN114080215A (en) * | 2019-08-14 | 2022-02-22 | 韩国科玛株式会社 | Elastomeric liposome composition comprising sucrose-based surfactant and cosmetic composition containing the same |
| CN114366679A (en) * | 2022-01-13 | 2022-04-19 | 拉芳家化股份有限公司 | Liposome containing organic acid microparticles and preparation method thereof |
| KR20220052560A (en) * | 2020-10-21 | 2022-04-28 | 주식회사 코리아나화장품 | Cosmetic composition comprising deformable liposome with effects of alleviating skin irritation and promoting skin absorption |
-
2022
- 2022-05-25 CN CN202210577130.6A patent/CN114886786B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100043748A (en) * | 2008-10-21 | 2010-04-29 | (주)네오팜 | Elastic liposome and composition of skin external application containing the same |
| CN109700671A (en) * | 2018-02-13 | 2019-05-03 | 深圳高尚科美生物科技有限公司 | Flexible lipidosome cosmetics and preparation method thereof comprising active small molecular substance |
| CN111195230A (en) * | 2018-11-19 | 2020-05-26 | 奥维嘉生物科技（北京）有限公司 | Method for preparing flexible liposome |
| KR20200095244A (en) * | 2019-01-31 | 2020-08-10 | 서울과학기술대학교 산학협력단 | A deformable liposome prepared with natural surfactants and use of the same |
| CN114080215A (en) * | 2019-08-14 | 2022-02-22 | 韩国科玛株式会社 | Elastomeric liposome composition comprising sucrose-based surfactant and cosmetic composition containing the same |
| KR20210095352A (en) * | 2020-01-23 | 2021-08-02 | (주)에이티 랩 | Manufacturing method of liposome with enhanced skin permeation |
| WO2021235767A1 (en) * | 2020-05-19 | 2021-11-25 | 주식회사 스타스테크 | Method for obtaining collagen peptide from starfish, elastic liposome comprising starfish-derived collagen peptide, and cosmetic composition comprising same |
| KR20220052560A (en) * | 2020-10-21 | 2022-04-28 | 주식회사 코리아나화장품 | Cosmetic composition comprising deformable liposome with effects of alleviating skin irritation and promoting skin absorption |
| CN114366679A (en) * | 2022-01-13 | 2022-04-19 | 拉芳家化股份有限公司 | Liposome containing organic acid microparticles and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| Physical Characterizations and In Vitro Skin Permeation of Elastic Liposomes for Transdermal Delivery of Polygonum aviculare L. Extract;Saet Byeol Han，等;Polymer(Korea);第38卷(第6期);694-701 * |
| 醇传递体在透皮给药系统中的研究进展;赵丹丹;于莲;冯幸福;戚映丹;应晓英;高建青;;中国现代应用药学;第36卷(第09期);1166-1171 * |
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