CN114849016A - Variable vascular microcatheter and method of use - Google Patents
Variable vascular microcatheter and method of use Download PDFInfo
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- CN114849016A CN114849016A CN202210547564.1A CN202210547564A CN114849016A CN 114849016 A CN114849016 A CN 114849016A CN 202210547564 A CN202210547564 A CN 202210547564A CN 114849016 A CN114849016 A CN 114849016A
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- 238000000034 method Methods 0.000 title claims abstract description 17
- 230000002792 vascular Effects 0.000 title claims abstract description 12
- 238000005452 bending Methods 0.000 claims abstract description 37
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 13
- 238000002583 angiography Methods 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims abstract description 5
- 239000011248 coating agent Substances 0.000 claims abstract description 4
- 238000000576 coating method Methods 0.000 claims abstract description 4
- 238000007906 compression Methods 0.000 claims description 7
- 230000006835 compression Effects 0.000 claims description 6
- 239000004677 Nylon Substances 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 230000007704 transition Effects 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000011218 segmentation Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/32—General characteristics of the apparatus with radio-opaque indicia
Abstract
The invention discloses a variable vascular microcatheter and a use method thereof, comprising a plurality of double-layer elastic catheters which are arranged in sequence, wherein adjacent double-layer elastic catheters are connected through snap rings; bending connecting wires are arranged along the length direction of the double-layer elastic conduit, and the bending connecting wires are arranged at equal intervals along the circumferential direction of the double-layer elastic conduit; the double-layer elastic catheter comprises an elastic outer catheter arranged on the outermost layer and used for moving in blood vessels, an elastic inner catheter arranged on the innermost layer and used for moving a micro guide wire and a medicine or a stent, and the turning positions of the bending connecting wires are respectively connected with the elastic outer catheter or the elastic inner catheter on the same side; the elastic outer conduit of part of the double-layer elastic conduit is provided with an annular hole; the micro-catheter can be flexibly assembled according to an angiography result, the flexibility of each position is adjusted, and various conveying requirements are met; the whole uniform diameter-changing structure is adopted, the connection is firm, the hydrophilic coating is sprayed on the outer surface, the operability is good, and the twisting and the internal blockage of the catheter can be effectively prevented, so that the operation process is influenced.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a variable vascular microcatheter and a using method thereof.
Background
In the clinical treatment of many diseases (e.g., hemangiomas, blood loss, and tumors), embolization of target blood vessels may be required. In cancer therapy, particularly tumors that are difficult to access and cannot be surgically removed, blockage of the blood supply flow is almost the only method; however, when it is desired to deliver a drug, therapeutic composition or other therapeutic substance to the site of the lesion to be treated, a microcatheter is often used as a delivery channel to assist in the delivery.
Patent document No. 2019109758629 discloses an embolism microcatheter, through setting up the first section near, the second section near, gradual change section and the distal segment that the weaving layer thickness is degressive along body distal end direction segmentation, the propelling movement nature, compliance and the trafficability characteristic of microcatheter have been improved, however, this kind is along the design that propelling movement direction compliance degressive in proper order, when meetting the obstacle, the tip is buckled easily, and to the blood vessel is more complicated, need the place of many places buckling, because the flexibility of each segmentation is the same, can cause extra stress to the blood vessel.
Disclosure of Invention
The technical purpose is as follows: aiming at the defects that the end part of the existing micro-catheter is easy to bend, the adaptability to a complex vascular access is not strong, extra stress is easy to generate and the like, the invention discloses a vascular micro-catheter with a variable bending position capable of being adjusted according to the treatment field condition and a using method thereof.
The technical scheme is as follows: in order to achieve the technical purpose, the invention adopts the following technical scheme:
a variable blood vessel micro-catheter comprises a plurality of double-layer elastic catheters which are arranged in sequence, wherein adjacent double-layer elastic catheters are connected in a matching way through clamping rings; bending connecting wires are arranged along the length direction of the double-layer elastic conduit, and the bending connecting wires are arranged at equal intervals along the circumferential direction of the double-layer elastic conduit; the double-layer elastic catheter comprises an elastic outer catheter arranged on the outermost layer and used for moving in blood vessels, an elastic inner catheter arranged on the innermost layer and used for moving a micro guide wire and a medicine or a stent, and the turning positions of the bending connecting wires are respectively connected with the elastic outer catheter or the elastic inner catheter on the same side.
Preferably, the bent connecting wire adopts a zigzag structure, the bent positions are in curve transition, the distance between two bent points on the same side of the bent connecting wire is smaller than the elastic distance of the double-layer elastic catheter between the corresponding bent points, and a compression cavity is formed between the bent connecting wire and the double-layer elastic catheter.
Preferably, the double-layer elastic catheter adopts a reducing structure, the pipe diameter is uniformly reduced from the near end to the far end, and the minimum pipe diameter of the elastic outer catheter is less than 0.003 inch.
Preferably, the side surface inclination angle of the clamping ring is matched with the taper of the double-layer elastic conduit, the end parts of the double-layer elastic conduit at the two ends of the clamping ring are respectively provided with an external thread, the external threads at the two end parts are opposite, the inner ring of the clamping ring is provided with an internal thread corresponding to the external thread, and the length of the internal thread is smaller than that of the corresponding external thread.
Preferably, in the double-layer elastic catheter, the inner part of the elastic outer catheter of the partial double-layer elastic catheter of the invention is provided with a plurality of annular holes for facilitating compression along the circumferential direction.
Preferably, the double-layer elastic catheter is made of a block copolymer of nylon and polyethylene oxide, and a developing ring for displaying the position is nested at the far end of the double-layer elastic catheter.
Preferably, the exterior of the elastic outer catheter of the present invention is coated with a hydrophilic coating.
Preferably, the inner surface of the elastic outer guide pipe and the outer surface of the elastic inner guide pipe adopt concave-convex structures corresponding to the bending connecting wires, and the contact surfaces of the elastic outer guide pipe and the elastic inner guide pipe are matched with each other to press the bending connecting wires tightly.
A use method based on the variable blood vessel micro-catheter comprises the following steps:
s01, confirming the bending point of the micro catheter according to the obtained image and the angiography of the human body, splicing a plurality of double-layer elastic catheters, wherein the bending point is provided with a double-layer elastic catheter with an annular hole;
s02, the spliced microcatheter is sent into a human body, the position of the end part of the microcatheter is judged by a developing ring at the end part of the microcatheter to reach the focus position, and the delivery is stopped;
s03, and then delivering the corresponding apparatus or medicine to the focus through the micro-guide wire for treatment.
Preferably, in the microcatheter of step S01 of the present invention, two microcatheters are used, wherein the elastic outer catheter of one microcatheter is integrally configured with a ring-shaped hole, and during the splicing process of the microcatheter, the double-layer elastic catheter without the ring-shaped hole corresponding to the turning point is replaced with the double-layer elastic catheter with the ring-shaped hole, and the two microcatheters are freely combined according to the angiography shape.
Has the advantages that: the variable blood vessel micro-catheter and the use method provided by the invention have the following beneficial effects:
1. the micro-catheter adopts the double-layer elastic catheters which are sequentially arranged, the adjacent double-layer elastic catheters are matched and connected through the snap ring, and the micro-catheter is designed in a multi-section mode, is convenient to carry, disassemble and store and is simple to assemble.
2. The bending connecting wire is arranged between the elastic outer conduit and the elastic inner conduit of the double-layer elastic conduit, the conduits on the inner layer and the outer layer are connected through the switching part of the bending connecting wire, the gap between the inner layer and the outer layer is kept, the flexibility of the micro-conduit is improved, and meanwhile, the micro-conduit can be prevented from being twisted to cause channel blockage by bending the connecting wire.
3. The bending connecting wire adopts a zigzag structure, adopts curve transition at the turning part, and forms a compression cavity with the double-layer elastic catheter, so that the stress is reduced when the bending is carried out.
4. The double-layer elastic inverted hanging adopts a reducing structure, the pipe diameter is uniformly reduced from the near end to the far end along the length direction of the micro-catheter, the whole body of the catheter body has a uniform reducing trend, the operability of the micro-catheter is improved, the rigidity of the near end is higher than that of the far end, and stress is transmitted layer by layer.
5. The side surface inclination angle of the clamping ring is matched with the taper of the double-layer elastic conduit, the clamping ring is in threaded fit connection with the double-layer elastic conduit at the two ends of the clamping ring, an inner thread is arranged on the inner ring of the clamping ring, the length of the inner thread is smaller than that of the corresponding outer thread, when the clamping ring is connected, the ends of the two double-layer elastic conduits are contacted in the clamping ring and mutually abutted, axial force is applied to the threads, and loosening is avoided.
6. According to the double-layer elastic catheter on the same microcatheter, a plurality of annular holes convenient to compress are formed in the inner part of the outer elastic catheter along the circumferential direction, so that the flexibility of the corresponding double-layer elastic catheter is improved, and the double-layer elastic catheter is convenient to match with blood vessels in the operation process.
7. The double-layer elastic catheter is made of a block copolymer of nylon and polyethylene oxide, so that the balance between hardness and elasticity is achieved, the developing ring for displaying the position is nested at the far end of the double-layer elastic catheter, the position of the end is displayed in real time, and the positioning in the operation is facilitated.
8. The micro catheter can be quickly adjusted to be fitted with the shape of a blood vessel when being conveyed to a diseased region, and the hydrophilic coating is arranged on the outer surface of the micro catheter, so that the micro catheter has good biocompatibility.
9. The inner surface of the elastic outer conduit and the outer surface of the elastic inner conduit adopt concave-convex structures corresponding to the bending connecting wires, the contact surfaces of the elastic outer conduit and the elastic inner conduit are matched with each other to tightly press the bending connecting wires, and the structure can be used in occasions needing to improve the rigidity of the micro-conduit.
10. When the micro catheter is used, the part of the micro catheter needing to be bent is replaced by the double-layer elastic catheter with the annular hole according to the angiography condition, and the use requirements of various situations can be met through the mutual combination of the two micro catheters.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below.
FIG. 1 is a diagram of a microcatheter of the present invention;
FIG. 2 is a block diagram of two double layer flexible conduits according to the present invention;
FIG. 3 is a partial enlarged view of the connection portion of the double-layer elastic catheter according to the present invention;
FIG. 4 is a view of the construction of the double layer flexible conduit with annular holes of the present invention;
FIG. 5 is a structural view of a double-layer flexible conduit according to embodiment 2 of the present invention;
FIG. 6 is a schematic view of a double-layer elastic catheter in a bent state according to the present invention;
wherein, 1-double-layer elastic conduit, 2-bending connecting wire, 3-elastic outer conduit, 4-elastic inner conduit, 5-annular hole, 6-snap ring, 7-compression cavity.
Detailed Description
The present invention will be more clearly and completely described below by way of a preferred embodiment in conjunction with the accompanying drawings, without thereby limiting the scope of the invention to the described embodiment.
As shown in fig. 1 and 2, the variable vascular microcatheter provided by the invention comprises a plurality of double-layer elastic catheters 1 which are sequentially arranged, wherein adjacent double-layer elastic catheters are connected in a matching way through a snap ring 6; the bending connecting wires 2 are arranged along the length direction of the double-layer elastic conduit 1, and the bending connecting wires 2 are arranged at equal intervals along the circumferential direction of the double-layer elastic conduit 1; the double-layer elastic catheter 1 comprises an elastic outer catheter 3 arranged on the outermost layer and used for moving in blood vessels, an elastic inner catheter 4 arranged on the innermost layer and used for moving a micro guide wire and a medicine or a stent, and the turning positions of the bending connecting wires 2 are respectively connected with the elastic outer catheter 3 or the elastic inner catheter 4 on the same side.
The bending connecting wire 2 adopts a zigzag structure, curve transition is adopted at the turning position, the distance between two turning points on the same side of the bending connecting wire 2 is smaller than the elastic distance of the double-layer elastic catheter between the corresponding turning points, and a compression cavity 7 is formed between the bending connecting wire 2 and the double-layer elastic catheter 1.
In order to balance the rigidity and the flexibility of the microcatheter, the double-layer elastic catheter 1 is made of a segmented copolymer of nylon and polyethylene oxide, an operation end is a near end, a conveying end is a far end, the pipe diameter of the microcatheter along the length direction is uniformly reduced, and the minimum pipe diameter of the far-end elastic outer catheter 3 is less than 0.003 inch.
As shown in fig. 1 and 3, the side inclination angle of the snap ring 6 is matched with the taper of the double-layer elastic conduit 2, the end parts of the double-layer elastic conduit at the two ends of the snap ring 6 are provided with external threads, the external threads of the two end parts are opposite, the inner ring of the snap ring 6 is provided with internal threads corresponding to the external threads, the length of the internal threads is smaller than the length of the corresponding external threads, when the double-layer elastic conduit 1 is connected, the end parts of the two double-layer elastic conduit 1 are contacted in the snap ring 6, the two double-layer elastic conduit 1 are tightly pressed against each other, axial force is applied to the threads, and looseness is avoided.
As shown in figure 4, in the double-layer elastic catheter of the invention, a plurality of annular holes 5 which are convenient to compress are arranged in the inner part of the elastic outer catheter of part of the double-layer elastic catheter along the circumferential direction, and when the microcatheter needs to turn or bend in a blood vessel, the microcatheter provided with the annular holes can improve the bending capability, improve the flexibility and facilitate the operation by matching with the compression cavity 7.
In order to improve the rigidity of the pipe section of the double-layer elastic conduit 1, the part which does not need to be bent or has a smaller bending angle can be set into a structure as shown in fig. 5, the inner surface of the elastic outer conduit 3 and the outer surface of the elastic inner conduit 4 adopt concave-convex structures corresponding to the bent connecting wires, the contact surfaces of the elastic outer conduit 3 and the elastic inner conduit 4 are mutually matched, the bent connecting wires 2 are compressed, the rigidity and the force transmission are improved, and the operability of the micro-conduit is improved.
In addition, the far end of the double-layer elastic catheter 1 is nested with a developing ring for displaying the position, the position of the micro catheter is displayed, the developing ring can be lined on each clamping ring 6, the position of each section of double-layer elastic catheter can be monitored in real time, and the operation efficiency and the success rate are improved.
The invention also provides a use method based on the variable vascular microcatheter, which comprises the following steps:
s01, confirming the bending point of the micro catheter according to the obtained image and the angiography of the human body, splicing a plurality of double-layer elastic catheters, wherein the bending point is provided with a double-layer elastic catheter with an annular hole;
s02, the spliced microcatheter is sent into a human body, the position of the end part of the microcatheter is judged by a developing ring at the end part of the microcatheter to reach the focus position, and the delivery is stopped;
s03, and delivering the corresponding device or medicine to the focus through the micro-guide wire for treatment.
The microcatheter in the step S01 adopts two microcatheters, wherein the elastic outer catheter of one microcatheter integrally adopts a structure with an annular hole, and in the process of splicing the microcatheters, the double-layer elastic catheter without the annular hole corresponding to the turning part is replaced by the double-layer elastic catheter with the annular hole, and the two microcatheters are freely combined according to the shape of angiography, so that the microcatheters can meet the conveying requirements of various types, the universality is improved, and the disassembly, the assembly and the carrying are convenient; when the part is damaged and needs to be replaced, the corresponding double-layer elastic conduit section is directly replaced, integral replacement is not needed, and maintenance cost is saved.
The above description is only of the preferred embodiments of the present invention, and it should be noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the invention and these are intended to be within the scope of the invention.
Claims (10)
1. A variable vascular microcatheter, comprising: comprises a plurality of double-layer elastic conduits (1) which are arranged in sequence, and adjacent double-layer elastic conduits are connected in a matching way through clamping rings (6); the bending connecting wires (2) are arranged along the length direction of the double-layer elastic conduit (1), and the bending connecting wires (2) are arranged at equal intervals along the circumferential direction of the double-layer elastic conduit (1); the double-layer elastic catheter (1) comprises an elastic outer catheter (3) arranged on the outermost layer and used for moving in blood vessels, an elastic inner catheter (4) arranged on the innermost layer and used for moving a micro guide wire and a medicine or a stent, and the turning positions of the bending connecting wires (2) are respectively connected with the elastic outer catheter (3) or the elastic inner catheter (4) on the same side.
2. The variable vessel microcatheter of claim 1, wherein: the bending connecting wire (2) adopts a zigzag structure, curve transition is adopted at the turning positions, the distance between two turning points on the same side of the bending connecting wire (2) is smaller than the elastic distance of the double-layer elastic catheter between the corresponding turning points, and a compression cavity (7) is formed between the bending connecting wire (2) and the double-layer elastic catheter (1).
3. The variable vessel microcatheter of claim 1, wherein: the double-layer elastic catheter (1) adopts a reducing structure, and the diameter of the catheter is uniformly reduced from the near end to the far end.
4. A variable vascular microcatheter as in claim 3, wherein: the side inclination angle of snap ring (6) and the tapering phase-match of double-deck elasticity pipe (2), the double-deck elasticity pipe end that is located snap ring (6) both ends all sets up the external screw thread to two tip external screw threads are opposite, and the inner circle setting of snap ring (6) and the corresponding internal thread of external screw thread, internal thread length are less than corresponding external thread length.
5. The variable vessel microcatheter of claim 1, wherein: in the double-layer elastic conduit, a plurality of annular holes (5) which are convenient to compress are arranged in the inner part of the elastic outer conduit of part of the double-layer elastic conduit along the circumferential direction.
6. The variable vessel microcatheter of claim 1, wherein: the double-layer elastic catheter (1) is made of a block copolymer of nylon and polyethylene oxide, and a developing ring for displaying a position is nested at the far end of the double-layer elastic catheter (1).
7. The variable vessel microcatheter of claim 1, wherein: the exterior of the elastic outer catheter (3) is coated with a hydrophilic coating.
8. The variable vessel microcatheter of claim 1, wherein: the inner surface of the elastic outer guide pipe (3) and the outer surface of the elastic inner guide pipe (4) adopt concave-convex structures corresponding to the bent connecting wires, and the contact surfaces of the elastic outer guide pipe (3) and the elastic inner guide pipe (4) are matched with each other to compress the bent connecting wires (2).
9. The method of using a variable vascular microcatheter as in any of claims 1-8, wherein: the method comprises the following steps:
s01, confirming the bending point of the micro catheter according to the obtained image and the angiography of the human body, splicing a plurality of double-layer elastic catheters, wherein the bending point is provided with a double-layer elastic catheter with an annular hole;
s02, the spliced microcatheter is sent into a human body, the position of the end part of the microcatheter is judged by a developing ring at the end part of the microcatheter to reach the focus position, and the delivery is stopped;
s03, and delivering the corresponding device or medicine to the focus through the micro-guide wire for treatment.
10. The method of using a variable vascular microcatheter as in claim 9, wherein: in the microcatheter in the step S01, two microcatheters are adopted, wherein the elastic outer catheter of one microcatheter integrally adopts a structure with an annular hole, and in the process of splicing the microcatheters, the double-layer elastic catheter without the annular hole corresponding to the turning part is replaced by the double-layer elastic catheter with the annular hole, and the two microcatheters are freely combined according to the shape of angiography.
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|---|---|---|---|
| CN202210547564.1A CN114849016B (en) | 2022-05-20 | 2022-05-20 | Variable vascular microcatheter and method of use |
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| CN202210547564.1A CN114849016B (en) | 2022-05-20 | 2022-05-20 | Variable vascular microcatheter and method of use |
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| CN114849016B CN114849016B (en) | 2023-10-24 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684657A (en) * | 2017-08-17 | 2018-02-13 | 陈翔 | A kind of double-layer bend microtubular and its application method for artery chronic Occlusion interventional procedure |
| CN109663202A (en) * | 2019-01-17 | 2019-04-23 | 南京普微森医疗科技有限公司 | A kind of novel cerebrovascular drug sacculus dilating catheter |
| CN213823099U (en) * | 2020-10-29 | 2021-07-30 | 浙江省嘉善县第一人民医院 | Central venous catheter capable of being used for long time |
-
2022
- 2022-05-20 CN CN202210547564.1A patent/CN114849016B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684657A (en) * | 2017-08-17 | 2018-02-13 | 陈翔 | A kind of double-layer bend microtubular and its application method for artery chronic Occlusion interventional procedure |
| CN109663202A (en) * | 2019-01-17 | 2019-04-23 | 南京普微森医疗科技有限公司 | A kind of novel cerebrovascular drug sacculus dilating catheter |
| CN213823099U (en) * | 2020-10-29 | 2021-07-30 | 浙江省嘉善县第一人民医院 | Central venous catheter capable of being used for long time |
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| CN114849016B (en) | 2023-10-24 |
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