CN114848762B - Traditional Chinese medicine composition for treating parkinsonism as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating parkinsonism as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating parkinsonism as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-55 parts of dried orange peel, 35-50 parts of poria cocos, 25-40 parts of bighead atractylodes rhizome, 25-40 parts of coix seed, 25-35 parts of gastrodia elata, 20-35 parts of earthworm, 15-25 parts of codonopsis pilosula, 15-25 parts of ligusticum wallichii, 12-20 parts of achyranthes root, 12-20 parts of Chinese angelica, 15-25 parts of cornus officinalis and 5-8 parts of honey-fried licorice root. The Chinese medicinal composition has effects of regulating qi-flowing, invigorating spleen, eliminating dampness, resolving phlegm, calming endogenous wind, and relieving spasm, and has good therapeutic effect on spleen deficiency and phlegm stagnation type Parkinson disease.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating parkinsonism as well as a preparation method and application thereof.
Background
Parkinson's disease is a common degenerative disorder of the middle-aged and elderly nervous system. The degenerative diseases of nervous system refer to dysfunction caused by degeneration of neurons and demyelination, such as muscle stiffness, tremors, inability to maintain balance, and memory deterioration. Although parkinson's disease is associated with a number of factors, the exact cause of the pathogenesis is not known. The western medicine is mostly treated by levodopa, dopaminergic receptor agonists, anticholinergic drugs, amantadine and the like, or assisted surgery treatment means. Although western medicines can inhibit tremor, muscle rigidity and other behaviors to a certain extent, the western medicines have side effects, and the traditional Chinese medicines have small toxic and side effects and are suitable for long-term administration. Therefore, the continuous research of new traditional Chinese medicine composition has important significance for treating the parkinsonism.
Disclosure of Invention
In view of the above technical problems, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for treating parkinsonism, which is prepared from the following raw materials in parts by weight: 30-55 parts of dried orange peel, 35-50 parts of poria cocos, 25-40 parts of bighead atractylodes rhizome, 25-40 parts of coix seed, 25-35 parts of gastrodia elata, 20-35 parts of earthworm, 15-25 parts of codonopsis pilosula, 15-25 parts of ligusticum wallichii, 12-20 parts of achyranthes root, 12-20 parts of Chinese angelica, 15-25 parts of cornus officinalis and 5-8 parts of honey-fried licorice root.
Preferably, the feed additive is prepared from the following raw materials in parts by weight: 35-45 parts of dried orange peel, 35-45 parts of poria cocos, 30-40 parts of bighead atractylodes rhizome, 30-40 parts of coix seed, 30-35 parts of gastrodia elata, 25-30 parts of earthworm, 15-20 parts of codonopsis pilosula, 15-20 parts of ligusticum wallichii, 15-18 parts of achyranthes root, 15-18 parts of Chinese angelica, 20-25 parts of cornus officinalis and 5-8 parts of honey-fried licorice root.
Preferably, the feed additive is prepared from the following raw materials in parts by weight: 38 parts of dried orange peel, 40 parts of poria cocos, 30 parts of bighead atractylodes rhizome, 32 parts of coix seed, 30 parts of gastrodia tuber, 28 parts of earthworm, 18 parts of codonopsis pilosula, 15 parts of szechuan lovage rhizome, 15 parts of twotooth achyranthes root, 15 parts of Chinese angelica, 22 parts of cornus officinalis and 6 parts of honey-fried licorice root.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating parkinsonism, which comprises the following steps:
s1, weighing pericarpium citri reticulatae, poria cocos, bighead atractylodes rhizome, coix seed, rhizoma gastrodiae, earthworm, codonopsis pilosula, ligusticum wallichii, achyranthes root, angelica sinensis, cornus officinalis and honey-fried licorice root according to parts by weight for standby;
s2, mixing the weighed raw material medicaments, soaking the raw material medicaments in water, decocting, filtering the decoction, and concentrating the decoction to obtain the traditional Chinese medicine composition.
Preferably, the soaking in water is carried out by adding water which is 8-10 times of the total weight of the medicinal materials, and soaking for 8-12h;
the decoction is 2-3 times of 1.5-2.5h each time.
Preferably, the concentration is to a relative density of 1.05-1.12 at 25 ℃.
The invention also provides application of the traditional Chinese medicine composition for treating parkinsonism in preparing a medicine for treating parkinsonism with spleen deficiency and phlegm obstruction.
Preferably, the traditional Chinese medicine composition can be further prepared into a pharmaceutically acceptable oral preparation.
Preferably, the oral preparation is decoction, tablets, capsules, granules or oral liquid.
The invention also provides a traditional Chinese medicine preparation for treating parkinsonism, which comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials or carriers.
The parkinsonism belongs to the categories of tremor, tremor and the like in traditional Chinese medicine. The theory of "the bone, marrow, if the body is not upright for a long time, the body is tired and the bones are left out" in the theory of the essence of the pulse ∈ -. "Lingqiu ≡ pathogenic factors guest" indicates that: the pathogenic qi is bad, the blood is not retained, the tendons, collaterals and bones are injured, and the muscles and bones are not bent and stretched, so the spasm is enough. "Fahrenheit, tibetan ∈ ∈theory of tendons and tendons, and the seventeenth theory of tendons and tendons" says: the patient can walk and rush rapidly, and the liver is damaged by pathogenic factors, and loses qi, so that the patient is cold and can not get away for a long time and flow into tendons, and the tendons of the patient are urgent and can not walk and relax. The walking stroke, which is not relaxed, corresponds to the behavior of the panic gait in parkinson's disease. The pathogenesis of the disease is complex, while the pathogenesis core is wind-qi internal movement, the pathogenesis essence can be treated by deficiency-excess theory, and the deficiency-excess condition is considered to be more, and the disease is generally considered to be caused by deficiency of liver and kidney yin, deficiency of qi and blood, malnutrition of tendons and vessels, and internal movement of deficient wind, or wind-fire with phlegm and mutual obstruction of collaterals.
The traditional Chinese medicine composition provided by the invention has the advantages that the dried orange peel and the poria cocos serve as the main ingredients, and the traditional Chinese medicine composition has the effects of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm, and is used for eliminating dampness and middle energizer; the bighead atractylodes rhizome, the coix seed, the tall gastrodia tuber and the earthworm are ministerial drugs, the bighead atractylodes rhizome has the same nature and taste as monarch drugs, and the monarch drugs are helpful for strengthening spleen and eliminating dampness; coix seed is light in taste and cool, and has the effects of promoting diuresis and removing dampness and strengthening spleen; gastrodia elata has the effects of calming endogenous wind, relieving spasm, dispelling pathogenic wind, dredging collaterals, and calming spleen, and is used for treating liver wind disturbance caused by qi and blood deficiency; earthworm, which can clear heat and relieve spasm; codonopsis pilosula, ligusticum wallichii, achyranthes bidentata, angelica sinensis and cornus officinalis are used as guiding drugs, codonopsis pilosula, middle-jiao and Qi are compensated, and crops are earthed up to help the dried orange peel to resolve phlegm without hurting the vital energy, release the middle-jiao and force without greasiness, and tonify Qi to control liver wind internal movement; chuan Xiong, dang Gui, niu xi and Di Long are combined, di Huang is salty and cold, and is easy to walk and flee, take Chuan Xiong, dang Gui and niu xi to reach the limbs and bones, promote blood circulation to remove blood stasis, dispel wind and relieve pain, dang Gui can tonify blood to control liver wind internal movement; achyranthes and cornus officinalis are used together, and can tonify liver and kidney, strengthen tendons and bones, nourish tendons and vessels, and kidney produce essence, and kidney essence is sufficient, so marrow is biochemically active, marrow sea is sufficient, and meridians are mainly tremor and stopped by limbs; radix Glycyrrhizae Preparata is used for strengthening tendons and bones, invigorating spleen and stomach, nourishing yin and blood, and relieving qi, and harmonizing the above drugs. The Chinese medicinal preparation has the effects of regulating qi, strengthening spleen, eliminating dampness, resolving phlegm, calming endogenous wind and relieving spasm, and has a good treatment effect on the parkinsonism caused by spleen deficiency and phlegm obstruction.
Detailed Description
The following detailed description is, therefore, to be taken in conjunction with the specific embodiments, it is to be understood that the scope of the invention is not limited to the specific embodiments.
Example 1
A traditional Chinese medicine composition for treating parkinsonism is prepared from the following raw materials: 30g of dried orange peel, 35g of poria cocos, 25g of bighead atractylodes rhizome, 25g of coix seed, 25g of gastrodia tuber, 20g of earthworm, 15g of codonopsis pilosula, 15g of szechuan lovage rhizome, 12g of twotooth achyranthes root, 12g of Chinese angelica, 15g of cornus officinalis and 5g of honey-fried licorice root.
Example 2
A traditional Chinese medicine composition for treating parkinsonism is prepared from the following raw materials: 55g of dried orange peel, 50g of poria cocos, 40g of bighead atractylodes rhizome, 40g of coix seed, 35g of gastrodia tuber, 35g of earthworm, 25g of codonopsis pilosula, 25g of szechuan lovage rhizome, 20g of twotooth achyranthes root, 20g of Chinese angelica, 25g of cornus officinalis and 8g of honey-fried licorice root.
Example 3
A traditional Chinese medicine composition for treating parkinsonism is prepared from the following raw materials: 38g of dried orange peel, 40g of poria cocos, 30g of bighead atractylodes rhizome, 32g of coix seed, 30g of gastrodia tuber, 28g of earthworm, 18g of codonopsis pilosula, 15g of szechuan lovage rhizome, 15g of twotooth achyranthes root, 15g of Chinese angelica, 22g of cornus officinalis and 6g of honey-fried licorice root.
Example 4
A traditional Chinese medicine composition for treating parkinsonism is prepared from the following raw materials: 35g of dried orange peel, 35g of poria cocos, 30g of bighead atractylodes rhizome, 30g of coix seed, 30g of gastrodia tuber, 25g of earthworm, 15g of codonopsis pilosula, 15g of szechuan lovage rhizome, 15g of twotooth achyranthes root, 15g of Chinese angelica, 20g of cornus officinalis and 5g of honey-fried licorice root.
Example 5
A traditional Chinese medicine composition for treating parkinsonism is prepared from the following raw materials: 45g of dried orange peel, 45g of poria cocos, 40g of bighead atractylodes rhizome, 40g of coix seed, 35g of gastrodia elata, 30g of earthworm, 20g of codonopsis pilosula, 20g of ligusticum wallichii, 18g of achyranthes root, 18g of Chinese angelica, 25g of cornus officinalis and 8g of honey-fried licorice root.
Example 6
A traditional Chinese medicine composition for treating parkinsonism is prepared from the following raw materials: 40g of dried orange peel, 40g of poria cocos, 28g of bighead atractylodes rhizome, 25g of coix seed, 32g of gastrodia tuber, 25g of earthworm, 20g of codonopsis pilosula, 20g of szechuan lovage rhizome, 15g of twotooth achyranthes root, 15g of Chinese angelica, 22g of cornus officinalis and 8g of honey-fried licorice root.
Example 7
A traditional Chinese medicine composition for treating parkinsonism is prepared from the following raw materials: 48g of dried orange peel, 45g of poria cocos, 40g of bighead atractylodes rhizome, 35g of coix seed, 30g of gastrodia tuber, 28g of earthworm, 15g of codonopsis pilosula, 15g of szechuan lovage rhizome, 20g of twotooth achyranthes root, 20g of Chinese angelica, 18g of cornus officinalis and 5g of honey-fried licorice root.
The traditional Chinese medicine compositions provided in the above examples 1 to 7 are all prepared according to the following method:
s1, weighing pericarpium citri reticulatae, poria cocos, bighead atractylodes rhizome, coix seed, rhizoma gastrodiae, earthworm, codonopsis pilosula, ligusticum wallichii, achyranthes root, angelica sinensis, cornus officinalis and honey-fried licorice root for standby;
s2, mixing the weighed raw medicinal materials, adding water which is 8 times of the total weight of the medicinal materials, soaking for 12 hours, decocting for 2 times and 2.5 hours each time, filtering the obtained decoction, and concentrating to obtain the product with the relative density of 1.05 at 25 ℃.
Example 8
The Chinese medicinal composition for treating parkinsonism is different from example 7 only in the preparation method, specifically:
s1, weighing pericarpium citri reticulatae, poria cocos, bighead atractylodes rhizome, coix seed, rhizoma gastrodiae, earthworm, codonopsis pilosula, ligusticum wallichii, achyranthes root, angelica sinensis, cornus officinalis and honey-fried licorice root for standby;
s2, mixing the weighed raw medicinal materials, adding water which is 10 times of the total weight of the medicinal materials, soaking for 8 hours, decocting for 3 times and 1.5 hours each time, filtering the obtained decoction, and concentrating to obtain the product with the relative density of 1.12 at 25 ℃.
The traditional Chinese medicine composition provided by the embodiment can be further prepared into oral preparations such as granules, tablets, capsules, oral liquid and the like according to a conventional pharmaceutical method.
Taking traditional Chinese medicine granules as an example, the preparation method specifically comprises the following steps:
further concentrating the obtained traditional Chinese medicine composition into thick extract (1.35-1.40, 50-60 ℃), and mixing the dried powdered sugar, dextrin and the thick extract according to the mass ratio of 3:1:1 mixing, adding 65% ethanol solution, making into soft material with the advantages of kneading, slightly pressing, dispersing, granulating, drying at 50-60deg.C, and grading.
Since the effects of the Chinese medicinal compositions provided in examples 1 to 8 are substantially the same, the effects will be described below by taking the Chinese medicinal composition provided in example 3 as an example.
Referring to "Zhang Ke Feng Ding Hu Wan" for treating liver and kidney yin deficiency in the middle of Parkinson's disease clinical [ D ]. Henan Chinese medicine institute, 2011:5-9.
1. General data
80 Parkinson patients who are treated by a first affiliated hospital of Henan traditional Chinese medicine university from 8 months in 2019 to 6 years in 2021 are selected and randomly divided into a treatment group and a control group, wherein the treatment group comprises 21 men and 19 women, and the average age is 65.42 +/-2.33 years; control group 17 men and 23 women, average age 64.68.+ -. 4.51 years old. The two general data were comparable with no significant difference (P > 0.05).
2. Diagnostic criteria
2.1 Western diagnostic criteria: reference was made to the 1995 Water Yemian primary Parkinson's disease diagnostic criteria.
2.2 diagnostic criteria for chinese medicine: the evaluation and treatment standard is formulated by referring to the Chinese medicine senile fibrillation diagnosis and treatment evaluation standard formulated by the China national Chinese medicine society of 11 months in 1991, and the diagnosis can be carried out when the main symptoms are equal to or greater than 4 minutes and the secondary symptoms are equal to or greater than 3 minutes.
3. Inclusion criteria
(1) Meets the diagnostic standards of the traditional Chinese and western medicine for PD;
(2) Meets the traditional Chinese medicine diagnosis standard of spleen deficiency and phlegm obstruction of the fibrillation syndrome;
(3) Age 50-75 years old;
(4) Modified Hoehn & Yahr is rated on a scale of 2-3.
4. Exclusion criteria
(1) Various parkinsonism, parkinsonism plus syndrome, essential tremor and other non-PD persons;
(2) History of abuse or history of alcohol abuse;
(3) Pregnant women and lactating women;
(4) Participation in other researchers;
(5) The levodopa preparation or the spleen-strengthening and phlegm-resolving traditional Chinese medicine is adopted to treat the patients without drug elution;
(6) Patients with severe heart, liver and kidney diseases or multiple organ failure, mental disease;
(7) Allergic constitution and various drugs.
5. Reject criteria and drop criteria
(1) Cases that do not meet inclusion criteria but are included by mistake;
(2) Patient compliance is poor, and patients who do not take medicines according to the regulations;
(3) The observation result is possibly influenced by taking other medicines during taking;
(4) A self-exit for some reason;
(5) Serious adverse reactions occur;
(5) The follower is somehow not accepted.
6. Therapeutic method
The treatment group takes the traditional Chinese medicine composition provided in the embodiment 3 of the invention, one dose is taken every day, and 3 months is a treatment course;
the control group takes the phenyllansoprazole hydrochloride (Hezhou Kangpu pharmaceutical Co., ltd.) 1-2mg daily, and 2mg every 3-5 days later until the curative effect is best without side reaction, and no more than 10mg daily, and takes the composition for 3-4 times for three months continuously.
6. Observation index
(1) UPDRS3.0 score before and after treatment;
(2) Scoring of Chinese medical syndromes;
(3) SF-36 integration;
(4) Safety index: testing blood, urine and feces conventionally; electrocardiography, liver function, kidney function examination, 1 time before and after treatment.
7. Statistical analysis
Statistical analysis is performed by adopting SPSS16.0 medical statistical software, the metering data adopts t test, the counting data adopts chi-square test or rank sum test, and the P value less than or equal to 0.05 has obvious statistical significance for the tested difference.
8. Results
8.1 comparison of UPDRS score before and after treatment of two groups
The results are shown in Table 1.
Table 1 two sets of pre-treatment and post-treatment UPDRS scores
| Grouping | n | Before treatment | After treatment |
| Treatment group | 40 | 62.35±1.26 | 54.32±1.76 * |
| Control group | 40 | 60.47±2.14 | 53.28±2.41 * |
Note that: * P<0.05
as can be seen from table 1: there was a significant difference in UPDRS scores (P < 0.05) between the pre-treatment and post-treatment comparisons in both groups, with no significant difference (P > 0.05) between the treatment group and the control group.
8.2, integral comparison of the Chinese medical symptoms before and after treatment
The results are shown in Table 2.
TABLE 2 integral comparison of the symptoms of traditional Chinese medicine before and after treatment
| Grouping | n | Before treatment | After treatment |
| Treatment group | 40 | 19.48±1.13 | 13.53±1.84 * |
| Control group | 40 | 17.89±2.25 | 12.33±1.69 * |
Note that: * P<0.05
as can be seen from table 2: the traditional Chinese medicine syndrome integral before and after treatment in the two groups has significant difference (P < 0.05), and the treatment group and the control group have no significant difference (P > 0.05).
8.3 comparison of SF-36 integral before and after treatment of two groups
The results are shown in Table 3.
Table 3 comparison of SF-36 integral before and after treatment of two groups
| Grouping | n | Before treatment | After treatment |
| Treatment group | 40 | 346.59±25.46 | 492.37±39.78 * |
| Control group | 40 | 361.24±31.34 | 447.26±37.65 * |
Note that: * P<0.05
as can be seen from table 3: comparing SF-36 integration before and after treatment in both groups has significant difference (P < 0.05), indicating that both groups can improve patient survival; the treatment group had a significant difference (P > 0.05) compared to the control group, indicating that the treatment group can significantly improve the quality of life of the patient.
8.4 safety evaluation
The liver and kidney functions, the electrocardiogram and the like of 80 patients are checked before and after the treatment, and obvious abnormality (P is more than 0.05) is not found. The control group showed dry mouth and blurred vision in 7 cases, and the treatment group showed no abnormal reaction in 4 cases of nausea and vomiting. In both groups, serious adverse reactions such as postural hypotension and arrhythmia are not found.
The foregoing disclosure is merely illustrative of some embodiments of the invention, but the embodiments are not limited thereto and variations within the scope of the invention will be apparent to those skilled in the art.
Claims (9)
1. The traditional Chinese medicine composition for treating the spleen deficiency and phlegm obstruction type parkinsonism is characterized by being prepared from the following raw materials in parts by weight: 35-45 parts of dried orange peel, 35-45 parts of poria cocos, 30-40 parts of bighead atractylodes rhizome, 30-40 parts of coix seed, 30-35 parts of gastrodia elata, 25-30 parts of earthworm, 15-20 parts of codonopsis pilosula, 15-20 parts of ligusticum wallichii, 15-18 parts of achyranthes root, 15-18 parts of Chinese angelica, 20-25 parts of cornus officinalis and 5-8 parts of honey-fried licorice root.
2. The traditional Chinese medicine composition for treating spleen deficiency and phlegm stagnation type parkinsonism according to claim 1 is characterized by being prepared from the following raw materials in parts by weight: 38 parts of dried orange peel, 40 parts of poria cocos, 30 parts of bighead atractylodes rhizome, 32 parts of coix seed, 30 parts of gastrodia tuber, 28 parts of earthworm, 18 parts of codonopsis pilosula, 15 parts of szechuan lovage rhizome, 15 parts of twotooth achyranthes root, 15 parts of Chinese angelica, 22 parts of cornus officinalis and 6 parts of honey-fried licorice root.
3. A method for preparing a traditional Chinese medicine composition for treating parkinson's disease due to spleen deficiency and phlegm obstruction according to any one of claims 1-2, comprising the following steps:
s1, weighing pericarpium citri reticulatae, poria cocos, bighead atractylodes rhizome, coix seed, rhizoma gastrodiae, earthworm, codonopsis pilosula, ligusticum wallichii, achyranthes root, angelica sinensis, cornus officinalis and honey-fried licorice root according to parts by weight for standby;
s2, mixing the weighed raw material medicaments, soaking the raw material medicaments in water, decocting, filtering the decoction, and concentrating the decoction to obtain the traditional Chinese medicine composition.
4. The method for preparing the traditional Chinese medicine composition for treating the spleen deficiency and phlegm stagnation type parkinsonism according to claim 3, which is characterized in that,
the soaking in water is carried out by adding water which is 8-10 times of the total weight of the medicinal materials, and soaking for 8-12h;
the decoction is 2-3 times of 1.5-2.5h each time.
5. The method for preparing a Chinese medicinal composition for treating parkinson's disease due to spleen deficiency and phlegm obstruction according to claim 3, wherein the concentration is to a relative density of 1.05-1.12 at 25 ℃.
6. Use of a traditional Chinese medicine composition for treating spleen-deficiency phlegm-obstruction type parkinson's disease according to any one of claims 1-2 in preparing a medicament for treating spleen-deficiency phlegm-obstruction type parkinson's disease.
7. The traditional Chinese medicine composition for treating parkinson's disease due to spleen deficiency and phlegm obstruction according to any one of claims 1-2, wherein the traditional Chinese medicine composition can be further prepared into a pharmaceutically acceptable oral preparation.
8. The Chinese medicinal composition for treating parkinson's disease due to spleen deficiency and phlegm stagnation according to claim 7, wherein said oral preparation is a decoction, a tablet, a capsule, a granule or an oral liquid.
9. A Chinese medicinal preparation for treating spleen deficiency and phlegm obstruction type parkinsonism, which is characterized by comprising the Chinese medicinal composition according to any one of claims 1-2 and pharmaceutically acceptable auxiliary materials or carriers.
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| CN1772107A (en) * | 2005-10-27 | 2006-05-17 | 叶明伟 | Chinese herbal medicine decoction for treating Qi deficiency blood stasis type senile tremor and palsy and its prepn |
| CN110279824A (en) * | 2019-05-22 | 2019-09-27 | 曹子成 | A kind of Chinese medicine composition and its application for treating Parkinson's disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1772107A (en) * | 2005-10-27 | 2006-05-17 | 叶明伟 | Chinese herbal medicine decoction for treating Qi deficiency blood stasis type senile tremor and palsy and its prepn |
| CN110279824A (en) * | 2019-05-22 | 2019-09-27 | 曹子成 | A kind of Chinese medicine composition and its application for treating Parkinson's disease |
Non-Patent Citations (1)
| Title |
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| 从虚、瘀论治帕金森病初探;王刚;王亚丽;郑静;;时珍国医国药;-;第-卷(第01期);第216-217页 * |
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