CN114832241A - Portable multi-mode treatment device for Alzheimer's disease and application - Google Patents

Portable multi-mode treatment device for Alzheimer's disease and application Download PDF

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CN114832241A
CN114832241A CN202210579157.9A CN202210579157A CN114832241A CN 114832241 A CN114832241 A CN 114832241A CN 202210579157 A CN202210579157 A CN 202210579157A CN 114832241 A CN114832241 A CN 114832241A
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led green
frequency
group
low
green lamp
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史贵连
叶福丽
李刚
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Hubei University of Science and Technology
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Hubei University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers

Abstract

The invention provides a portable multi-mode treatment device for Alzheimer's disease and application thereof, belonging to the technical field of medical instruments. The multi-mode treatment device comprises a 40Hz frequency LED green lamp group, a 40Hz audio device, a low-frequency focused ultrasound group and a low-frequency unfocused ultrasound group; the 40Hz frequency LED green lamp group comprises a multivibrator and an LED green lamp group; the multivibrator can control the on and off of the LED green lamp group; the LED green lamp group is connected with a voltage division circuit, and the voltage division circuit can adjust the voltage at two ends of the LED green lamp group so as to change the brightness of the LED green lamp group; the low-frequency focused ultrasound group comprises two focused ultrasound transducers; the low-frequency non-focusing ultrasonic group comprises three non-focusing ultrasonic transducers, the device introduces gamma waves into the brain and fully utilizes the mechanical effect and biochemical effect generated by low-intensity ultrasonic, reduces the accumulation of amyloid plaques and Tau protein of A beta, reduces neurofibrillary tangles, promotes the propagation of nerve cells and improves the function of the glial cells.

Description

Portable multi-mode treatment device for Alzheimer's disease and application
Technical Field
The invention belongs to the technical field of medical instruments, and relates to a portable multi-mode treatment device for Alzheimer's disease and application thereof.
Background
The characteristic pathological change of the Alzheimer disease is abnormal deposition of amyloid A beta in brain, and senile plaque is formed; tau protein in the brain is over-phosphorylated, forming neurofibrillary tangles and neuron loss in nerve cells, accompanied by glia cell proliferation. Senile plaque, neuron tangle and gliosis pathological changes in the brain promote the occurrence of Alzheimer disease. The medicines and nursing of the Alzheimer disease are very expensive, and bring a heavy economic burden to the society, and the most affected is not the patient himself but the family members of the patient. According to statistics, more than 80% of the families of senile dementia patients have emotional disorders in different degrees, and the patients often cannot communicate with the families, so that the families cannot see the hope of curing. Scientists have long sought a drug or method for treating or delaying the onset of alzheimer's disease without loss. In 6 months 2021, the FDA announced that a new drug for treating alzheimer's disease, adacanaumab, was approved for use, and this was the first drug for treating alzheimer's disease worldwide for 20 years. The monoclonal antibody drug taking Abeta as a therapeutic target brings eosin to a large number of patients, but the treatment effect of the monoclonal antibody drug also causes great disputes among Alzheimer disease medical workers and scientists all over the world. Other treatment methods such as repeated transcranial magnetic stimulation, transcranial direct current stimulation and the like have certain effects on the treatment of the Alzheimer's disease, but due to the reasons of low spatial resolution, shallow surface of a stimulation part and the like, certain application requirements cannot be met, meanwhile, side effects cannot be ignored, and even epileptic seizure can be caused in severe cases. Traditional Chinese medicine and acupuncture are widely adopted in the treatment of the Alzheimer's disease, and the treatment method based on the dialectical thought is often used as a supplement to Western-style treatment methods and physical therapy means of the Alzheimer's disease, and the treatment effect of the treatment method needs to be further verified.
In general, the existing treatment drugs and methods can only relieve the symptoms of the alzheimer disease and delay the worsening process, but cannot achieve the aim of reversibly treating the alzheimer disease, which is also the limitation of the existing treatment drugs and methods. Under the condition that the aging problem of the population in China is more severe, the method is undoubtedly a research subject with great value.
Disclosure of Invention
The invention aims to provide a portable multi-mode treatment device for Alzheimer's disease, aiming at the problems in the prior art, and the technical problem to be solved by the invention is to integrate three modes of light, sound and ultrasound for nerve cell propagation and improvement of the function of the nerve microglia.
The purpose of the invention can be realized by the following technical scheme: a portable multi-mode treatment device for Alzheimer's disease comprises a 40Hz frequency LED green lamp group, a 40Hz audio device, a low-frequency focused ultrasound group, a low-frequency unfocused ultrasound group and an operation table.
The three modes of light, sound and ultrasound are integrated to act on the brain of a patient, gamma waves are introduced into the brain, the mechanical effect and the biochemical effect generated by low-intensity ultrasound are fully utilized, the accumulation of amyloid plaques and Tau protein of A beta is reduced, the neurofibrillary tangle is reduced, the propagation of nerve cells is promoted, and the function of the nerve microglia is improved.
The 40Hz frequency LED green light set comprises a multivibrator and an LED green light set. A 555 timer is adopted to manufacture a multivibrator, and the oscillation frequency of the multivibrator is 40Hz by reasonably setting the peripheral resistor and the capacitor of the 555 timer;
the multivibrator is used for controlling the on-off of the LED green light group, so that the LED green light group flickers at a corresponding frequency. Green is the most sensitive color of human retina and is the most comfortable in human perception;
the voltage at two ends of the LED green lamp group is adjusted through the voltage division circuit, so that the brightness of the LED green lamp group is changed, the retinal nerve can be effectively stimulated by the brightness of the LED green lamp group, and obvious glaring feeling is avoided;
further, the LED green lamp group comprises 35-40 LED green lamps driven by 5V voltage, and the LED green lamps are connected in parallel. The LED green lamps are distributed along the arc at equal intervals and are arranged at the edge of the brim of the hat, and the LED green lamps are covered with a layer of diffuser to reduce the discomfort of the eyes caused by light;
optionally, the 40Hz audio uses a low capacity SD Card/TF Card (Secure Digital Card/TransTlash Card) to store audio information, and the audio is stored in MP3 format;
furthermore, the MP3 decoding chip decodes the audio information into audio signals, the audio signals are amplified by the power amplifier and then transmitted to the earphones at two sides, and the audio signals are played circularly, so that a large-capacity SD/TF card is not needed. The amplification factor of the power amplifier is adjustable, the amplified audio signals are transmitted to two ears of a patient through the earphone, and the patient can adjust the volume to a position where the ears feel comfortable according to personal needs;
furthermore, the irradiation duration of the LED green light group and the playing duration of the 40Hz audio frequency are controlled by the single chip microcomputer, the duration is set to be between 40 and 60 minutes, and a patient can adjust the irradiation duration and the 40Hz audio frequency playing duration of the specific LED green light group according to the actual needs and the tolerance of the patient. And after the treatment time is set, displaying the residual time through the liquid crystal screen, wherein the residual time is displayed accurately to seconds. When the set irradiation duration is reached, the LED green lamp group and the 40Hz audio signal are automatically disconnected;
optionally, two high-frequency signal generating circuits are adopted, and the two high-frequency signal generating circuits are subjected to power amplification, proper matching and the like to form two ultrasonic transducer driving power supplies with different frequencies;
one of the driving power supplies is responsible for driving the power supply of the low-frequency focused ultrasound group, and the low-frequency focused ultrasound group comprises two focused ultrasound transducers, so that the output frequency of the two focused ultrasound transducers is 250 KHz and the intensity of the two focused ultrasound transducers is 0.40-0.65W/cm 2 And the pulse ultrasonic on-off ratio is 1: 3. The two focusing ultrasonic transducers are respectively arranged at the left side and the right side of the back part of the top of the head, and the positions of the focusing ultrasonic transducers are properly adjusted by combining the MRI images of the head and the focal length of the focusing ultrasonic transducers, so that the ultrasonic energy is respectively gathered on the hippocampus at the two sides of the cranium and the entorhinal cortex beside the hippocampus. A couplant is applied between the focused ultrasound transducer and the scalp to reduce attenuation of the ultrasound transmission. The irradiation time of the focused ultrasonic transducer is controlled by the singlechip, the irradiation time is set in the range of 10-15 minutes, the remaining time is displayed by the liquid crystal screen, and the remaining time is displayed accurately to seconds. When the set irradiation duration is reached, the two focused ultrasonic transducers are automatically stopped simultaneously;
the other driving power supply is responsible for supplying power to the low-frequency unfocused ultrasonic group, and specifically, the low-frequency unfocused ultrasonic group comprises three unfocused ultrasonic transducers, so that the output frequency of the unfocused ultrasonic transducers is 1200 KHz and the output frequency of the unfocused ultrasonic transducers is 1500KHz, and the intensity of the unfocused ultrasonic transducers is 0.25-0.50W/cm 2 And the pulse ultrasonic on-off ratio is 1: 2. The three non-focusing ultrasonic transducers are respectively arranged in the scalp areas corresponding to the prefrontal lobe and the temporal lobes on the left side and the right side. A couplant is applied between the transducer and the scalp to reduce attenuation of the ultrasonic transmission. And similarly, the irradiation time of the non-focusing ultrasonic transducer is controlled by a singlechip, the irradiation time is set in the range of 35-40 minutes, the residual irradiation time is displayed by a liquid crystal screen, and the residual irradiation time is displayed accurately to seconds. When the set irradiation duration is reached, the three unfocused ultrasonic transducers are automatically stopped simultaneously;
when the whole light-sound-ultrasonic combined treatment process is finished, the treatment is prompted to be finished through voice broadcasting and indicator lamp flickering for 3 times;
the setting and control circuit (including light-sound-ultrasound), the ultrasonic transducer driving power supply, the treatment ending prompting circuit and the transformer of the parameters are all centralized in the operation table. The operation panel sets up liquid crystal display, concentrates each item parameter of demonstration light, sound and supersound to include: setting duration, intensity and remaining time of light-sound; setting the output frequency and the output intensity of the two focused ultrasounds, and setting the time length and the remaining time; the output frequency, the output intensity, the set duration and the remaining time of the three unfocused ultrasounds. A left arrow adjusting key and a right arrow adjusting key (the left arrow is adjusted to be larger and the right arrow is adjusted to be smaller) are respectively and correspondingly designed, and the parameters are adjusted within a limited range to meet the individual requirements of treatment of patients;
by the method, the generation of 40Hz pulse control waves and the setting of the intensity and the time length of light and sound effects in the light-sound-ultrasound combined therapy are realized, and the setting of the irradiation time length, the ultrasonic frequency and the ultrasonic intensity in the ultrasonic treatment mode is also realized. Further, the aim of safely and effectively treating Alzheimer's disease is achieved based on the set parameters and the intracranial region location of the MRI image.
The LED green lamp group is connected with the operating console, and the irradiation time length and the brightness of the LED green lamp are regulated and controlled through an LED parameter selection key and a left/right arrow adjusting key (the left is turned up and the right is turned down) corresponding to the operating console; the earphone is connected with the operation table, and the regulation and control of the playing time length and the playing intensity of the 40Hz audio frequency are realized through an audio frequency parameter selection key and a left/right arrow adjusting key (the left adjustment is large and the right adjustment is small) corresponding to the operation table; the ultrasonic transducer group is connected with the operation table, two groups of transducers are provided, one group is a focusing ultrasonic transducer, the other group is a non-focusing ultrasonic transducer, the two groups of transducers respectively correspond to an ultrasonic 'parameter selection' key and a left/right arrow adjusting key (left adjustment is large and right adjustment is small) of the operation table, and the control of the irradiation duration, the ultrasonic frequency and the ultrasonic intensity of the focusing ultrasonic transducer and the non-focusing ultrasonic transducer can be realized by operating the keys. The operating table is also provided with an 'intelligent' key, after the key is pressed, a user does not need to do 'parameter selection' operation every time of treatment, and the device automatically operates according to the parameters selected at the previous time.
The positive progress effects of the invention are as follows: the method comprises the steps of firstly, jointly adopting three treatment modes of light, sound and ultrasound, taking a characteristic region of Alzheimer disease intracranial lesion as a treatment target region, integrating treatment advantages of the three modes, and optimizing the treatment effect of Alzheimer disease; the treatment parameters of the three modes of the device can be freely set, so that the individual requirements of the diseases of the patients are met; thirdly, the intelligent key is convenient and quick to operate, parameters do not need to be adjusted every time of treatment, and the intelligent key is particularly convenient for the old to use; and the portable design expands the use occasion of the device, and the patient does not need to be limited to a fixed place for treatment.
The human brain can produce a variety of brain waves in different behaviors or states, wherein gamma waves (typically 40Hz) are involved in higher functions of the brain such as attention, cognitive ability, or working memory. Recent research results show that the gamma wave is abnormal in the early stage of Alzheimer's disease, even before any symptoms are not found. The research finds that: the 'light + sound' stimulation with the frequency of 40Hz can reduce the accumulation of amyloid of A beta and Tau protein, further reduce plaque, and the positive effect extends to the hippocampus and prefrontal cortex; the functions of the neuron and the synapse are enhanced, and the 'immune phagocytic' function of the glial cell is effectively improved.
Ultrasound is a mechanical pressure wave. A large number of studies show that the low-intensity ultrasound with proper frequency can stimulate and regulate neurons and neural circuits, change the potential activity of hippocampal tissue cells of patients, stimulate the regeneration of the neurons and promote the generation of new cells. The transcranial low-intensity focused ultrasound (tLIFUS) has precise focusing area and deep penetrating part, and can reach the nuclear mass in the brain. When the brain areas such as hippocampus, temporal lobe and the like are irradiated by the tLIFUS with proper frequency and intensity, the accumulation of A beta plaques and Tau protein can be effectively reduced, the neurofibrillary tangle is reduced, the propagation of nerve cells and the growth of astrocytes are promoted, and the cognitive ability of a patient is improved. In addition, low intensity ultrasound of appropriate frequency, acting on intracranial vascular endothelial cells, can enhance vascular nitric oxide synthase activity and promote nitric oxide synthesis. Nitric oxide is a soluble physiological signal molecule and can be used for reducing diseases such as atherosclerosis.
The scheme mainly provides a combined light, sound and ultrasonic three-dimensional treatment mode which can be used alternatively or additionally, wherein the related single circuit and single control mode are the common knowledge in the field which can be realized by the prior means.
Drawings
Fig. 1 is a schematic structural diagram of a light-sound-ultrasound combined treatment operation table of the invention.
Fig. 2 is a flow chart of a portable multi-mode treatment device for alzheimer's disease according to the present invention.
FIG. 3 is a flow chart of the LED green light set control according to the present invention.
Fig. 4 is a flow chart of audio processing and control in accordance with the present invention.
FIG. 5 is a flow chart of the generation and control of the low intensity ultrasound suite of the present invention.
Detailed Description
The following are specific embodiments of the present invention and are further described with reference to the drawings, but the present invention is not limited to these embodiments.
Fig. 1 is a schematic structural diagram of a light-sound-ultrasound combined treatment operation table of the invention. As shown in fig. 1, the light-sound-ultrasound combination treatment operation table of the present invention mainly comprises the following parts: the ultrasonic diagnosis device comprises a liquid crystal display screen 2, a power input interface 3, an operation panel power master switch 8, a power indicator lamp 9, an intelligent key 10, an LED green lamp ' parameter selection ' key 11 and a left/right arrow key on the left side of the LED green lamp ' parameter selection ' key 12 and a left/right arrow key on the left side of the LED green lamp ' parameter selection ' key, a focused ultrasonic group ' parameter selection ' key 13 and a left/right arrow key on the left side of the focused ultrasonic group ' parameter selection ' key 14 and a left/right arrow key on the left side of the focused ultrasonic group ' 220V/AC power input end 3, an LED green lamp power output end 4, an audio signal output end 5, a focused ultrasonic group power output end 6 and a focused ultrasonic group power output end 7.
Wherein, the LCD screen 2 displays the set treatment parameters, including the remaining duration of the light-sound-ultrasonic action, the brightness of light, the intensity of sound frequency, the frequency and intensity of the focused ultrasonic group and the frequency and intensity of the unfocused ultrasonic group; 220V alternating current is input into the device through the power input interface 3, and the alternating current is processed by a transformer in the operation table to provide energy for the whole device; the intelligent key 10 enables the user to automatically operate the parameters selected in the previous time without the need of selecting the parameters every time of treatment, and is particularly convenient for the old to use; the LED green light 'parameter selection' key 11 is interchanged between two parameters of brightness and duration, and after a certain parameter is selected, the size of the parameter is adjusted (the left is adjusted to be larger and the right is adjusted to be smaller) through a left/right arrow key on the left side; the audio frequency parameter selection key 12 is interchanged between two parameters of strength and duration, and after a certain parameter is selected, the size of the parameter is adjusted (the left is adjusted to be larger and the right is adjusted to be smaller) through a left/right arrow key on the left side; the 'parameter selection' key 13 of the focused ultrasound group alternates among three parameters of frequency, intensity and duration, and after a certain parameter is selected, the size of the parameter is adjusted (adjusted to the left and adjusted to the right) through a left/right arrow key on the left side; the 'parameter selection' key 14 of the unfocused ultrasound group alternates among three parameters of frequency, intensity and duration, and after a certain parameter is selected, the size of the parameter is adjusted (adjusted to the left and adjusted to the right) through a left/right arrow key on the left side; the LED green light power output end 4, the audio signal output end 5, the focused ultrasound group power output end 6 and the unfocused ultrasound group power output end 7 respectively output the driving energy of the light, sound, focused ultrasound group and unfocused ultrasound group which are modulated according to set parameters.
Fig. 2 is a schematic overall framework diagram of a portable alzheimer disease multi-modal therapy apparatus according to the present invention. As shown in fig. 2, the portable optical-acoustic-ultrasonic multi-mode combination therapy apparatus mainly includes four modules: a 40Hz LED green light module; a 40Hz audio module; a low intensity focused ultrasound group; a low intensity unfocused ultrasound group.
The low-intensity focused ultrasound group comprises two focal length transducers and a control circuit thereof; the low intensity unfocused ultrasound suite includes three unfocused transducers and their control circuitry. In fig. 2, the control and regulation circuit of the 40Hz LED green light module, the control and regulation circuit of the 40Hz audio module, the low-intensity focused ultrasound group and the low-intensity unfocused ultrasound group are all integrated in the console. The first ultrasonic driving power supply is responsible for driving 2 focusing ultrasonic transducers, so that the output frequency of the focusing ultrasonic transducers is 250 KHz and the intensity of the focusing ultrasonic transducers is 0.40-0.65W/cm 2 Ultrasonic waves with pulse ultrasonic on-off ratio of 1: 3;
the second ultrasonic driving power supply is responsible for driving 3 unfocused ultrasonic transducers with output frequency of 1200-1500KHz and intensity of 0.25-0.50W/cm 2 And the pulse ultrasonic on-off ratio is 1: 2. The attenuation of ultrasonic wave is closely related to transmission medium, in the invention, the irradiation parts of two focusing transducers of the low-intensity focusing ultrasonic group are the left and right hippocampus in the deep part of brain and the entorhinal cortex beside the hippocampus, respectively, because the attenuation speed of the ultrasonic wave in the skull and brain tissue is higher, and the ultrasonic wave with lower frequency has better penetrability, on the basis of researching a large amount of domestic and foreign related documents and self-obtained experimental data, the invention selects the output frequency of 250-280KHz and the intensity of 0.40-0.65W/cm 2 The focusing ultrasonic wave with the pulse ultrasonic on-off ratio of 1:3 achieves the aim of safe and effective treatment; the irradiation parts of the three non-focusing transducers of the low-intensity non-focusing ultrasonic group are respectively the prefrontal lobe and the temporal lobes at the left and the right sides, so the invention selects the output frequency of 1200-1500KHz and the intensity of 0.25-0.50W/cm 2 The pulse ultrasonic on-off ratio is 1:2 to achieve the safe and effective ultrasonic waveThe purpose of treatment is.
FIG. 3 is a flow chart of an LED green light driving and control module according to the present invention. As shown in figure 3, 35-40 LED green lamps are adopted, the green lamps are distributed along the arc shape of the brim of a hat at equal intervals and are connected in parallel, and a layer of diffuser is covered outside to reduce the irritation of green light to eyeballs. A multivibrator is formed by a 555 timer and a proper peripheral circuit, and 5V voltage with the frequency of 40Hz is generated to drive the LED green lamp group. And the irradiation time and brightness of the LED green lamp are controlled by adopting a single chip microcomputer.
Fig. 4 is a flow diagram of the audio processing and control module of the present invention. As shown in fig. 4, 40Hz audio is stored in SD card or TF card in MP3 format, and the audio information is decoded by decoding chip and transmitted to the earphone after power method. The time length and the intensity of the audio frequency are controlled by the singlechip.
FIG. 5 is a flow chart of the low intensity ultrasound group generation and control module of the present invention. As shown in fig. 5, the low intensity ultrasound module consists of a low intensity focused ultrasound group and a low intensity unfocused ultrasound group.
The low-intensity focused ultrasound group comprises 2 focused transducers, the transducers are provided with driving energy by a first ultrasound driving power supply consisting of a high-frequency signal generator and a power amplifier, and are respectively connected with the 2 focused transducers after being matched by a matching circuit. The ultrasonic frequency, the intensity and the irradiation duration are adjusted by the singlechip.
The low-intensity non-focusing ultrasonic group comprises 3 non-focusing transducers, wherein the transducers are provided with driving energy by a second ultrasonic driving power supply consisting of a high-frequency signal generator and a power amplifier, and are respectively connected with the 3 non-focusing transducers after being matched by a matching circuit. The ultrasonic frequency, the intensity and the irradiation duration are adjusted by the singlechip.
It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.

Claims (6)

1. A portable multi-mode treatment device for Alzheimer's disease is characterized by comprising a 40Hz frequency LED green lamp group, a 40Hz audio device, a low-frequency focused ultrasound group and a low-frequency unfocused ultrasound group;
the 40Hz frequency LED green lamp group comprises a multivibrator and an LED green lamp group;
the multivibrator can control the on and off of the LED green lamp group;
the LED green lamp group is connected with a voltage division circuit, and the voltage division circuit can adjust the voltage at two ends of the LED green lamp group so as to change the brightness of the LED green lamp group;
the low-frequency focused ultrasound group comprises two focused ultrasound transducers;
the low frequency unfocused ultrasound group includes three unfocused ultrasound transducers.
2. The portable multi-mode treatment device for the Alzheimer's disease according to claim 1, wherein the LED green light group comprises 35-40 LED green lights driven by 5V voltage, and the LED green lights are connected in parallel; the LED green lamps are distributed along the arc at equal intervals and are arranged at the brim edge of the hat with the hat, and the LED green lamps are covered with a layer of diffuser.
3. The portable alzheimer's disease modality treatment device of claim 1, wherein the 40Hz audio device employs a low capacity SD/TF card for storing audio information, the audio being stored in MP3 format.
4. The portable Alzheimer's disease multi-mode treatment device of claim 1, wherein the focused ultrasound transducer outputs 250 KHz and 280KHz of intensity of 0.40-0.65W/cm 2 And the pulse ultrasonic on-off ratio is 1: 3.
5. The portable tool according to claim 1The multi-mode treatment device for the Alzheimer disease is characterized in that the output frequency of the non-focusing ultrasonic transducer is 1200 KHz and 1500KHz, and the intensity is 0.25-0.50W/cm 2 And the pulse ultrasonic on-off ratio is 1: 2.
6. Use of a portable multimodal treatment apparatus for alzheimer's disease characterized in that the multimodal treatment apparatus of any of claims 1-6 introduces gamma waves into the brain and takes full advantage of the mechanical and biochemical effects of low intensity ultrasound, reduces the accumulation of amyloid plaques of a β and Tau protein, reduces neurofibrillary tangles, promotes nerve cell proliferation and improves glial cell function.
CN202210579157.9A 2022-05-26 2022-05-26 Portable multi-mode treatment device for Alzheimer's disease and application Withdrawn CN114832241A (en)

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Application Number Priority Date Filing Date Title
CN202210579157.9A CN114832241A (en) 2022-05-26 2022-05-26 Portable multi-mode treatment device for Alzheimer's disease and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210579157.9A CN114832241A (en) 2022-05-26 2022-05-26 Portable multi-mode treatment device for Alzheimer's disease and application

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Application publication date: 20220802