CN114822894B

CN114822894B - Container for holding radiopharmaceutical vial and use thereof

Info

Publication number: CN114822894B
Application number: CN202210608881.XA
Authority: CN
Inventors: 杜泽天; 黄曾�; 田佳乐; 李刚; 郝晋; 熊晓玲; 阳国桂; 杨宇川
Original assignee: Sichuan Xiantong Atomic Pharmaceutical Technology Co ltd; Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics
Current assignee: Guotong Chengdu New Drug Technology Co ltd; Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics
Priority date: 2022-05-31
Filing date: 2022-05-31
Publication date: 2023-03-24
Anticipated expiration: 2042-05-31
Also published as: CN114822894A

Abstract

A container for holding a vial of radiopharmaceutical and the use thereof, said container comprising: the medicine bottle container comprises a container body, wherein an open accommodating groove is formed in the container body and is configured to accommodate the medicine bottle; and a cover body including a cover body and a protrusion extending from the bottom surface of the cover body in a direction away from the top surface of the cover body, wherein the protrusion is away from the end of the cover body and is provided with a pad part, the end of the pad part away from the cover body is provided with a first groove part, the side wall of the first groove part is gradually away from the cover body along with the axis of the cover body, the cover body is buckled on the container body, and the first groove part accommodates the top of the medicine bottle, so that the axis of the cover body and the axis of the medicine bottle are basically collinear.

Description

Container for holding radiopharmaceutical vial and use thereof

Technical Field

The present disclosure relates to the field of radiopharmaceutical storage, and relates to a container for holding a vial of radiopharmaceutical and its use.

Background

The radioactive medicines are special medicines containing radioactive nuclides and can provide diagnosis or treatment in medicine, the diagnosis radioactive medicines generally mainly emit gamma photons, the gamma photons have strong penetrating power, and can be easily detected by a nuclear medicine detection instrument in vitro after being introduced into a body, and the positions and changes of the gamma photons in the body can be recorded; the therapeutic radioactive drugs mainly emit electrons, and compared with diagnostic radioactive drugs, the therapeutic radioactive drugs have long half-life and short range, and can intensively irradiate diseased regions to obtain good therapeutic effect.

It also places special demands on the packaging container, also because of the presence of radioactivity. Firstly, the packaging container needs to meet the relevant requirements of radiation protection, namely, the packaging container can play a role in sufficient radiation shielding, so that the medicine filled in the packaging container does not irradiate people around; second, the radiopharmaceutical is typically contained in a vial and the manufacturing of the drug is completed in a radiation-shielding isolation system. Therefore, the radiation protection container for the radiopharmaceuticals can ensure that the radiopharmaceuticals can accurately fall into the radiation protection container when radiation protection packaging is carried out after the production of the medicinal preparations is finished; finally, the radiopharmaceutical is administered without removal of the container, usually in order to avoid additional exposure to surrounding medical personnel. The existing solutions are to take the pharmaceutical preparation out of the radiation-shielding container for administration, or to take the radiation-shielding container lid off for administration. This approach does not provide adequate radiation protection, is cumbersome to operate, and inevitably involves additional ionizing radiation exposure.

Disclosure of Invention

Some embodiments of the present disclosure provide a container containing a radiopharmaceutical vial, the container comprising:

the medicine bottle container comprises a container body, wherein an open accommodating groove is formed in the container body and is configured to accommodate the medicine bottle; and

the cover body comprises a cover body and a bulge part extending from the bottom surface of the cover body along the direction far away from the top surface of the cover body,

the end part of the bulge part far away from the cover body is provided with a rubber pad part, the end part of the rubber pad part far away from the cover body is provided with a first groove part, the side wall of the first groove part gradually gets away from the axis of the cover body along with the distance from the cover body,

the first slot portion receives the top of the vial such that an axis of the cap is substantially collinear with an axis of the vial in response to the cap being snapped onto the container body.

In some embodiments, the side wall of the first groove portion has an arc shape convex toward an axis of the lid body in a cross section passing through the axis.

In some embodiments, the bottom surface of the first trough portion has a shape and size substantially the same as the top surface of the vial.

In some embodiments, the cushion portion has a first through hole coaxial with the first groove portion and the cover body, the first through hole communicating with the first groove portion, and a cross-sectional area of the first through hole in a plane perpendicular to an axis of the cover body is smaller than a cross-sectional area of the first groove portion in a plane perpendicular to an axis of the cover body.

In some embodiments, the vial comprises:

a vial body configured to house a radiopharmaceutical;

the rubber cover is buckled at the opening of the medicine bottle body; and

a packaging cover which is provided with an opening and wraps and locks the peripheral area of the rubber cover on the medicine bottle body, the opening exposes the middle part of the rubber cover,

the shape and the size of the cross section of the first through hole on a plane perpendicular to the axis of the cover body are basically the same as those of the opening hole, the top surface of the packaging cover abuts against the bottom surface of the first groove part in response to the cover body being buckled on the container body, and the projection of the first through hole on the packaging cover is basically overlapped with the opening hole.

In some embodiments, the protruding portion further includes a hard portion detachably connected to the rubber pad portion, wherein a clamping groove is formed in a side wall of the hard portion, and a clamping portion matched with the clamping groove is formed at an end portion, close to the cover body, of the rubber pad portion.

In some embodiments, the locking groove is arranged on the periphery of the side wall of the hard portion, and is in a continuous or discontinuous ring shape.

In some embodiments, the engaging portion of the cushion portion encloses a second slot portion in which the hard portion is received away from the top of the cap body.

In some embodiments, the accommodating groove includes a first accommodating space, a second accommodating space, and a third accommodating space adjacent to each other in sequence near the bottom of the accommodating groove, the third accommodating space being configured to accommodate at least a portion of the medicine bottle;

the convex part comprises a first convex part and a second convex part which are sequentially far away from the top surface of the cover body, wherein the second convex part comprises the rubber pad part,

wherein the first sidewall of the first accommodating space extends along a first direction, the first direction is parallel to the axis of the container body, the second sidewall of the second accommodating space gradually converges from the end part of the first sidewall close to the second accommodating space to the axis of the container body in the first direction, the third sidewall of the third accommodating space extends along the first direction from the end part of the second sidewall far from the first accommodating space,

the first outer side wall of the first convex part extends along a second direction, the second direction is parallel to the axis of the cover body, the second outer side wall of the second convex part gradually converges from the end part of the first outer side wall close to the first convex part to the axis of the cover body in the second direction,

in response to the cover being snapped onto the container body, the first and second protrusions are received in the first and second receiving spaces, respectively, the first outer sidewall is in mating engagement with the first sidewall, and the second sidewall is in mating engagement with at least a portion of the second outer sidewall such that the axis of the container body is substantially collinear with the axis of the cover.

In some embodiments, the container body comprises:

the outer body is internally provided with a first open accommodating groove; and

an inner body detachably accommodated in the first accommodating groove, a second accommodating groove with an opening is arranged in the inner body,

the second accommodating groove comprises a second accommodating space and a third accommodating space in response to the inner body being mounted in a first accommodating groove of the outer body, and the first accommodating space is formed by the space from the top of the inner body to the top of the outer body in the first accommodating groove.

In some embodiments, the material of the outer body is primarily at least one or a combination of lead, lead alloy, or tungsten alloy, and the material of the inner body is primarily at least one or a combination of lead, lead alloy, tungsten, or organic polymer material.

Some embodiments of the present disclosure also provide a use of a container for holding a vial of a radiopharmaceutical, the container being as described in the preceding embodiments.

Relative to the related art, the present disclosure has at least the following technical effects:

the container comprises a container body made of materials with radiation protection function and a cover body, wherein a rubber pad part is arranged at one end part of a protruding part of the cover body, a first groove part is arranged at the end part, far away from the cover body, of the rubber pad part, and the first groove part is used for accommodating the top of the medicine bottle positioned in the container in response to the cover body being buckled on the container body, so that the axis of the cover body and the axis of the medicine bottle are basically collinear. Make the medicine bottle is in firm the placing in the container to make can be basically aligned with the medicine bottle of the holding radiopharmaceutical in the storage tank after the through-hole on the syringe subassembly inserted the lid, thereby realize that under the condition that the medicine bottle of holding radiopharmaceutical is located the container of protecting against radiation, will the medicine bottle inserts injection system, has reduced medical personnel and radiopharmaceutical's contact, supplies radiation protection for medical personnel.

Furthermore, the inner side wall of the accommodating groove in the container body and the outer side wall of the protruding portion of the cover body have specific shapes matched with each other, so that when the cover body is buckled on the container body, the first axis of the container body and the second axis of the cover body are basically collinear, the cover body and the container body are aligned and buckled, and the situation that large deviation exists in the horizontal direction when the cover body is buckled with the container body is avoided. Thereby substantially collinear the first axis of the container body, the second axis of the cap body, and the third axis of the vial. So can be so when follow-up medicine bottle that will be equipped with the radiopharmaceutical inserts injection system, the syringe subassembly can align with the medicine bottle of the holding radiopharmaceutical in the storage tank basically after inserting the through-hole on the lid to the realization is located the condition in the container of protecting against radiation at the medicine bottle of holding radiopharmaceutical, will medicine bottle inserts injection system, has reduced medical personnel and radiopharmaceutical's contact, supplies radiation protection for medical personnel.

The rubber pad part is made of elastic materials, and the medicine bottle is prevented from being damaged when being abutted against the rubber pad part.

The container body comprises an outer body and an inner body, the inner body is detachably arranged in the outer body, and the different second accommodating grooves of the inner bodies are different and can be used for accommodating medicine bottles with different sizes.

Drawings

In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present disclosure, and other drawings can be obtained according to the drawings without creative efforts for those skilled in the art.

Fig. 1 is a schematic structural view of a container provided in some embodiments of the present disclosure;

fig. 2 is a schematic illustration of an exploded structure of a container provided in some embodiments of the present disclosure;

FIG. 3 is a schematic diagram of a container access injection system containing a vial containing a radiopharmaceutical provided in some embodiments of the present disclosure;

FIG. 4 is a schematic cross-sectional view of FIG. 3;

FIG. 5 is an exploded view of a container body provided in some embodiments of the present disclosure;

FIG. 6 is a schematic structural view of various inner bodies provided in some embodiments of the present disclosure;

FIG. 7 is a schematic illustration of an exploded view of a container according to further embodiments of the present disclosure;

fig. 8 is a schematic perspective view of a cushion portion according to some embodiments of the present disclosure;

FIG. 9 is a cross-sectional view of a cushion portion provided in some embodiments of the present disclosure;

FIG. 10 is a schematic cross-sectional view of FIG. 3 in further embodiments;

fig. 11 is a schematic structural view of a vial provided in some embodiments of the present disclosure;

FIG. 12 is a schematic cross-sectional view of a vial according to some embodiments of the present disclosure;

fig. 13 is a schematic top view of a vial according to some embodiments of the present disclosure;

FIG. 14 is an exploded cross-sectional view of the cover of FIG. 7;

fig. 15 is a schematic structural view of an injection system provided in some embodiments of the present disclosure;

FIG. 16 is a schematic structural view of a push-pin assembly provided in some embodiments of the present disclosure;

FIG. 17 is an enlarged view of region M of FIG. 10;

fig. 18 is a schematic cross-sectional view of the region N in fig. 16.

Detailed Description

To make the objects, technical solutions and advantages of the present disclosure more apparent, the present disclosure will be described in further detail with reference to the accompanying drawings, and it is apparent that the described embodiments are only some embodiments of the present disclosure, not all embodiments. All other embodiments, which can be derived by one of ordinary skill in the art from the embodiments disclosed herein without making any creative effort, shall fall within the scope of protection of the present disclosure.

The terminology used in the embodiments of the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used in the disclosed embodiments and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise, and "a plurality" typically includes at least two.

It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.

It is also noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that an article or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such article or apparatus. Without further limitation, the recitation of an element by the phrase "comprising a" does not exclude the presence of additional like elements in a commodity or device comprising the element.

In the medical field, radioprotection is required for vials containing radiopharmaceuticals, such as penicillin vials, which are typically placed in a radiation-protected container, such as a lead can. The container is used as a carrier to carry or transfer vials containing the radiopharmaceutical. However, when a medical staff member needs to insert a medicine bottle containing a radioactive drug into a syringe system for injecting the radioactive drug into a human body, the medical staff member is usually required to take the medicine bottle out of a container with radiation protection, and then manually insert the medicine bottle into the syringe system, for example, manually insert a liquid guide needle in a syringe assembly in the syringe system into the medicine bottle from a cover body of the medicine bottle, and then input the radioactive object into a patient through a catheter or the like, so as to complete the treatment. In this case, the medical staff inevitably comes into close contact with the vial containing the radiopharmaceutical, with the risk of receiving the radiation.

The present disclosure provides a container for holding a radiopharmaceutical vial, the container comprising: the medicine bottle container comprises a container body, wherein an open accommodating groove is formed in the container body and is configured to accommodate the medicine bottle; and a cover body including a cover body and a protrusion extending from the bottom surface of the cover body in a direction away from the top surface of the cover body, wherein the protrusion is away from the end of the cover body and is provided with a pad part, the end of the pad part away from the cover body is provided with a first groove part, the side wall of the first groove part is gradually away from the cover body along with the axis of the cover body, the cover body is buckled on the container body, and the first groove part accommodates the top of the medicine bottle, so that the axis of the cover body and the axis of the medicine bottle are basically collinear.

The container in the present disclosure may be used for both the transfer and transportation phase of a medicine bottle containing a radiopharmaceutical and the treatment phase of accessing the medicine bottle to an injection system, wherein an end of the protrusion of the cover is provided with a rubber pad portion, and an end of the rubber pad portion away from the cover body is provided with a first groove portion, and in response to the cover body being fastened to the container body, the first groove portion contains the top of the medicine bottle located in the container, so that the axis of the cover body and the axis of the medicine bottle are substantially collinear. And then make the syringe subassembly insert can align with the medicine bottle of the holding radiopharmaceutical in the storage tank basically after the through-hole on the lid to the realization is located under the condition of the container of protecting against radiation at the medicine bottle of holding radiopharmaceutical, will the medicine bottle inserts injection system, has reduced medical personnel and radiopharmaceutical's contact, supplies radiation protection for medical personnel.

Alternative embodiments of the present disclosure are described in detail below with reference to the accompanying drawings.

Fig. 1 is a schematic structural view of a container according to some embodiments of the present disclosure, and fig. 2 is a schematic structural view of an explosion of the container according to some embodiments of the present disclosure, in which a cover body is separated from a container body. As shown in fig. 1 and 2, the container 100 includes a container body 10 and a lid 20, and when the lid 20 is engaged with the container body 10, the container 100 forms a relatively closed space therein. In some embodiments, the body 10 and the cover 20 can be made of radiation-proof material, and can be one or a combination of lead, lead alloy or tungsten alloy, such as lead. Thus, the container 100 may be used to house vials of radiopharmaceutical, such as vials of penicillin. The container 100 can be used as a carrier for moving or transporting a medicine bottle of the radiopharmaceutical, so that radiation leakage and environmental pollution caused by the radiation leakage during the moving or transporting process are avoided.

As shown in fig. 1 and 2, an open receiving groove 13 is disposed in the container body 10, and the receiving groove 13 includes a first receiving space 131, a second receiving space 132 and a third receiving space 133 adjacent to each other in sequence near the bottom of the receiving groove, wherein the third receiving space 133 is configured to receive at least a portion of a medicine bottle containing a radiopharmaceutical.

The first sidewall 1311 of the first accommodating space 131 extends along a first direction, for example, a vertical direction Y, the first direction is parallel to the first axis m1 of the container body 10, the second sidewall 1321 of the second accommodating space 132 gradually converges from an end of the first sidewall 1311 close to the second accommodating space 132 to the first axis m1 of the container body 10 along the first direction, and the third sidewall 1331 of the third accommodating space 133 extends along the first direction from an end of the second sidewall 1321 far away from the first accommodating space 131. In some embodiments, the size of the third receiving space is substantially slightly larger than the size of the medicine bottle, so that the medicine bottle is prevented from shaking greatly in the horizontal direction during transportation when the medicine bottle is placed in the third receiving space.

The cover body 20 comprises a cover body 22 and a boss 21 extending from the bottom surface of the cover body 22 along the direction away from the top surface of the cover body, and the boss 21 comprises a first boss 211 and a second boss 212 which are sequentially away from the top surface of the cover body. The first outer side wall 2111 of the first protruding portion 211 extends along a second direction, for example, a vertical direction Y, the second direction is parallel to the second axis m2 of the cover 20, and the second outer side wall 2121 of the second protruding portion 212 gradually converges from the end of the first outer side wall 2111 close to the second protruding portion 212 to the second axis m2 of the cover 20 in the second direction.

When the cover 20 is snapped onto the container body 10, the first protruding portion 211 and the second protruding portion 212 are respectively received in the first receiving space 131 and the second receiving space 132, the first outer sidewall 1311 is in fit engagement with the first sidewall 2111, and the second sidewall 1321 is in fit engagement with at least a portion of the second outer sidewall 2121, such that the first axis m1 and the second axis m2 are substantially collinear.

Fig. 3 is a schematic view of a container access injection system containing a vial containing a radiopharmaceutical according to some embodiments of the present disclosure, and fig. 4 is a schematic cross-sectional view of fig. 3. As shown in fig. 1 to 4, the medicine bottle 300 containing the radiopharmaceutical is accommodated in the accommodating groove 13 of the container body 10, and specifically, a cylindrical body below the neck of the medicine bottle 300 is accommodated in the third accommodating space 133. The pusher assembly 200 of the injection system can be inserted into the vial 300 through the through-hole of the cap 20, such that, with the vial 300 containing the radiopharmaceutical in the radiation-resistant container 100, the vial 300 is inserted into the injection system, reducing exposure of the healthcare worker to the radiopharmaceutical and providing radiation protection to the healthcare worker, but such operation requires relatively precise alignment of the pusher assembly 200 with the vial 300 in the container 100.

In the disclosure, the inner side wall of the accommodating groove in the container body and the outer side wall of the protruding portion of the cover body have specific shapes matched with each other, so that when the cover body is fastened on the container body, the first axis of the container body and the second axis of the cover body are substantially collinear, the cover body and the container body are fastened in an aligned mode, and large deviation in the horizontal direction when the cover body is fastened with the container body is avoided. So can be so when follow-up medicine bottle that will be equipped with radiopharmaceutical inserts injection system, push away needle subassembly and can align with the medicine bottle of the holding radiopharmaceutical in the storage tank basically after inserting the through-hole on the lid to the realization is located the condition in the container of protecting against radiation at the medicine bottle of holding radiopharmaceutical, will medicine bottle inserts injection system, has reduced medical personnel and radiopharmaceutical's contact, supplies radiation protection for medical personnel.

Fig. 5 is an exploded view of a container body provided in some embodiments of the present disclosure. As shown in connection with fig. 1-5, container body 10 includes an outer body 11 and an inner body 12. The outer body is provided with a first containing groove 111 with an opening, the inner body 12 is detachably contained in the first containing groove 111, and the inner body 12 is provided with a second containing groove 121 with an opening. When the inner body 12 is mounted in the first receiving groove 111 of the outer body 11, the second receiving groove 121 includes the second receiving space 132 and the third receiving space 133, and the space from the top of the inner body 12 to the top of the outer body 11 in the first receiving groove 111 constitutes the first receiving space 131.

Because the inner body 12 and the outer body 11 are detachable, different inner bodies 12 can be installed in the same outer body, and different inner bodies 12 can have different second accommodating grooves for accommodating medicine bottles 300 of different sizes. When the container 100 is used for accommodating medicine bottles 300 of different sizes, only the different inner bodies 12 need to be replaced, and the container 100 does not need to be replaced integrally, so that the cost can be reduced.

For example, the inner body comprises a plurality of models of inner bodies, such as a first inner body and a second inner body of different models, fig. 6 is a schematic structural diagram of different inner bodies provided in some embodiments of the present disclosure. Fig. 6 (a) is a schematic structural view of the first inner body 12', and (B) is a schematic structural view of the second inner body 12 ″. As shown in fig. 5 to 6, the first inner body 12' and the second inner body 12 "have the same outer diameter and the same height, and the inclination of the sidewall of the second accommodating space 132' corresponding to the first inner body 12' is the same as the inclination of the sidewall of the second accommodating space 132" corresponding to the second inner body 12 ". Therefore, both can be installed into the first receiving groove 111 in the outer body 11, and the cover 20 can be fittingly fastened to the container body 10.

The height of the second accommodating space 132 'corresponding to the first inner body 12' is different from the height of the second accommodating space 132 "corresponding to the second inner body 12", for example, the height of the second accommodating space 132 'corresponding to the first inner body 12' is greater than the height of the second accommodating space 132 "corresponding to the second inner body 12". The outer diameter of the third receiving space 133 'corresponding to the first inner body 12' is different from the outer diameter of the third receiving space 133 "corresponding to the second inner body 12", for example, the outer diameter of the third receiving space 133 'corresponding to the first inner body 12' is smaller than the outer diameter of the third receiving space 133 "corresponding to the second inner body 12". The second inner body 12 "may accommodate a vial having a larger outer diameter than the first inner body 12'.

In some embodiments, the material of the outer body is a high-density metal material, and may be at least one or a combination of lead, lead alloy or tungsten alloy, such as lead, and the material of the inner body may be different according to the difference of the radiopharmaceuticals, and may be at least one or a combination of lead, lead alloy, tungsten, and organic polymer material, such as organic glass, which generates high-energy beta decay when the radiopharmaceuticals are radioactive glass microspheres, and the beta rays hit on the element with large atomic number to release strong bremsstrahlung radiation. The beta ray protection is firstly to use low Z material. Therefore, the inner body material is organic glass made of low-Z material, which is beneficial to reducing the bremsstrahlung radiation of the radioactive glass microspheres.

In some embodiments, referring to fig. 1-4, the cap 20 has a through hole 23 extending through the cap 20, the through hole 23 is configured to insert a push-pin assembly 200, and the container further comprises a plug body (not shown) matching the through hole, the plug body is configured to be inserted into the through hole 23. The axis of the through hole 23 coincides with the second axis m2 of the lid body 20, and passes through the boss portion 21 of the lid body 20. When the container 100 stores the vial 300 containing the radiopharmaceutical, the cap 20 is matched and buckled with the container body, and the plug body is inserted into the through hole 23 of the cap 20 to block the through hole 23, so that the sealed and isolated storage of the vial 300 containing the radiopharmaceutical is realized. In some embodiments, the cap and plug may both be made of a radiation-resistant material, such as lead, to avoid radiation leakage. When the radiopharmaceutical in the radiopharmaceutical bottle 300 needs to be injected into a patient for treatment, the medical staff can pull out the plug body from the cover body 20, insert the push needle assembly 200 in the injection system into the through hole 23 of the cover body 20, and then insert the liquid guide needle of the push needle assembly 200 into the radiopharmaceutical bottle 300 located in the third accommodating space 133 of the container 100 from the cover body of the radiopharmaceutical bottle, so that under the condition that the radiopharmaceutical bottle containing the radiopharmaceutical is located in the radiation-proof container, the radiopharmaceutical bottle is inserted into the injection system, contact between the medical staff and the radiopharmaceutical is reduced, and radiation protection is provided for the medical staff.

In some embodiments, as shown in fig. 1 to 4, in a cross section passing through the first axis m1, an included angle α between the second sidewall 1321 of the second accommodating space 132 and the first axis is 20 ° to 30 °. During the process of placing the vial containing the radiopharmaceutical into the container body 10, when the axis of the vial 300 is preferably aligned with the first axis m1 of the container body 10, the vial 300 can be directly placed into the third receiving space 133 of the container body 100. When the deviation between the axis of the medicine bottle 300 and the first axis m1 of the container body 10 is large, the bottom of the medicine bottle 300 may contact the second sidewall 1321 of the second accommodating space 132 first, and since the included angle α between the second sidewall 1321 and the first axis is 20 ° to 30 °, the medicine bottle 300 may slide into the third accommodating space 133 under the guidance of the second sidewall 1321.

In some embodiments, as shown in fig. 1-4, the sidewall of the cap body 22 of the cap body 20 is provided with a groove 221, the groove 221 is a continuous annular groove, and is disposed on the outer periphery of the sidewall of the cap body 22, and the groove 221 can also be an intermittent annular groove. The loading of the vial containing the radiopharmaceutical into the container 100 in the present disclosure may be accomplished by using a robotic arm, for example, first separating the cover 20 from the container body 10 by using the robotic arm, at which time the robotic arm may be inserted into the groove 221 to remove the cover 20 from the container body 10, then picking up the vial 300 containing the radiopharmaceutical and loading the vial 300 into the third accommodating portion 133 of the container body 10 by using the robotic arm, and then fastening the cover 20 to the container body 10 by using the robotic arm, and the whole process may be automatically completed by using the robotic arm without manual operation, and the above operations are completed in a closed space with radiation protection, for example, to prevent radiation from damaging human body.

In some embodiments, as shown in fig. 1-4, the container 100 is, for example, substantially cylindrical, as are the container body 10 and the lid body 22 of the lid body 20. The first receiving space 131 is cylindrical, the second receiving space 132 is inverted truncated cone-shaped, and the third receiving space 133 is cylindrical. The shape of the third receiving space 133 substantially matches the shape of the vial 300 of radiopharmaceutical. In some embodiments, as shown in fig. 4, when the vial 300 of radiopharmaceutical is loaded into the third accommodating space 133 of the container body 10, the portion below the neck of the vial 300 is accommodated in the third accommodating space 133, and the portion above the neck is accommodated in the second accommodating space 132, due to the specific structure of the accommodating groove 13 in the container body 10, i.e., the specific combination structure of the first accommodating space 131, the second accommodating space 132 and the third accommodating space 133, the holding of the neck of the vial 300 by the robot arm to place the vial 300 into the container body 10 or remove the vial 300 from the container body 10 can be facilitated.

In some embodiments, when the cover 20 is snapped onto the container body 10, the distance between the second protrusion 212 and the vial 300 in the first axial direction m1 is less than a predetermined distance, for example, 50mm. To avoid substantial vertical shaking of the vial 300 housed in the container 100. In some embodiments, when the cap 20 is snapped onto the container body 10, the second protrusion 212 abuts the vial 300.

In some embodiments, when the inner body 12 is installed in the outer body 11, the inner body 12 and the outer body 11 are in an interference fit, so as to prevent the inner body 12 from shaking in the first receiving groove 111 in the outer body 11, and ensure that the medicine bottle 300 is stably placed in the container body 100.

Fig. 7 is a schematic diagram of an exploded structure of a container according to other embodiments of the present disclosure, in which the container body is separated from the cover body, the rubber pad portion of the protruding portion of the cover body is separated from other portions of the cover body, and fig. 7 shows a medicine bottle 300 accommodated in the container. If the cushion portion is mounted at the end of the protruding portion, the overall structure of the cover body is similar to the cover body structure shown in fig. 2, and the same parts are not described again.

Referring to fig. 1 and 7, the container 100 includes a container body 10 and a lid 20, and when the lid 20 is engaged with the container body 10, a relatively closed space is formed inside the container 100. In some embodiments, the container body 10 and the cover 20 may be made of a radiation-proof material, such as lead, so that the container 100 may be used for accommodating a vial containing a radiopharmaceutical, such as a vial. The container 100 can be used as a carrier for moving or transporting a medicine bottle of the radiopharmaceutical, so that radiation leakage and environmental pollution caused by the radiation leakage during the moving or transporting process are avoided.

As shown in fig. 1 and 7, an open receiving groove 13 is disposed in the container body 10, and the receiving groove 13 is configured to receive at least a portion of a vial 300 containing a radiopharmaceutical. The containing groove includes, for example, the first containing space 131, the second containing space 132 and the third containing space 133 adjacent to each other in sequence near the bottom of the containing groove, wherein the third containing space 133 is configured to contain at least a portion of a medicine bottle containing a radiopharmaceutical. The cover body 20 includes a cover body 22 and a protrusion 21 extending from a bottom surface of the cover body 22 in a direction away from a top surface of the cover body 22. The end of the protruding portion 21 away from the cover body 22 is provided with a rubber pad portion 2123.

Fig. 8 is a schematic perspective view of a cushion portion provided in some embodiments of the present disclosure, and fig. 9 is a cross-sectional view of the cushion portion provided in some embodiments of the present disclosure. As shown in fig. 1,7-9, an end of the rubber pad part 2123 away from the cover body is provided with a first groove part 21231, and a side wall of the first groove part 21231 gradually gets away from an axis of the cover body as getting away from the cover body, i.e., a second axis m2. When the cap 20 is snapped onto the container body 10, the first groove 21231 receives the top of the vial 300 such that the second axis m2 of the cap 20 is collinear with the axis of the vial 300, hereinafter referred to as the third axis.

In this case, when the container 300 for holding a radiopharmaceutical vial is used in the above-mentioned container 100, and the cover 20 is aligned and fastened to the container body 10, the top surface of the vial is bound in the first groove 21231, so that the vial can be stably placed in the container, and the needle pushing assembly can be substantially aligned with the radiopharmaceutical vial in the holding groove after being inserted into the through hole of the cover, so that the vial can be connected to the injection system under the condition that the radiopharmaceutical vial is located in the radiation-proof container, thereby reducing the contact between the medical staff and the radiopharmaceutical, and providing radiation protection for the medical staff.

Specifically, referring to fig. 1,7-9, the dimension of the third receiving space 133 in the receiving groove 13 of the container body 10 in the second direction, e.g., the horizontal direction X, is usually slightly larger than the dimension of the medicine bottle 300 in the horizontal direction, e.g., the inner diameter of the third receiving space 133 is slightly larger than the diameter of the medicine bottle 300. This arrangement allows the vial 300 to be easily placed into the third receiving space 133 by a robot, allowing the robot holding the vial 300 to have a certain deviation in the alignment of the third receiving space 133. In this case, the third axis of the medicine bottle 300 does not necessarily coincide with the axis of the third accommodating space 133, i.e. the first axis m1 of the container body 10, which is not conducive to aligning the medicine bottle after inserting the push-pin assembly into the through hole of the cover body in the process of subsequently inserting the medicine bottle into the injection system.

With the embodiments, in the process of fastening the cover 20 to the container body with the medicine bottle 300, as the protruding portion 21 of the cover 20 gradually moves toward the bottom of the accommodating groove 13 in the container body 10, at least a portion of the side wall of the first groove portion 21231 first contacts the top of the medicine bottle 300, as the protruding portion 21 continues to penetrate into the accommodating groove 13, since the side wall of the first groove portion 21231 gradually moves away from the second axis m2 of the cover 22, the side wall of the first groove portion 21231 pushes the top of the medicine bottle 300, so that the top of the medicine bottle 300 is gradually aligned with the first groove portion 21231, and as the protruding portion 21 continues to move toward the bottom of the accommodating groove 13, the top of the medicine bottle 300 gradually enters the first groove portion 21231 of the cushion portion 2123, so that the third axis of the medicine bottle 300 is substantially collinear with the second axis of the cover 20. On the one hand, can be so that state medicine bottle 300 is in place firmly in container 100, avoid it to rock in the horizontal direction, on the other hand for can align with the medicine bottle of the holding radiopharmaceutical in the storage tank basically after the through-hole on the lid is inserted to the push pin subassembly, thereby realize under the condition that the medicine bottle of holding radiopharmaceutical is located the container of protecting against radiation, will medicine bottle access injection system has reduced medical personnel and radiopharmaceutical's contact, supplies radiation protection for medical personnel.

In some embodiments, the rubber pad portion 2123 is made of an elastic material, for example, so that the rubber pad portion abuts against the medicine bottle to prevent damage to the medicine bottle.

In some embodiments, as shown in fig. 9, a side wall of the first groove portion 21231 has an arc shape, for example, a circular arc shape, which is convex toward an axis of the cover body in a cross section passing through the axis. This may allow for a more compliant sliding abutting between the side walls of the first groove portion 21231 and the top of the vial 300.

In some embodiments, the bottom surface of the first groove portion 21231 has a shape and size substantially the same as the top surface of the vial 300, e.g., both are circular in shape and have substantially the same diameter. When the top of the medicine bottle 300 is received in the first groove 21231, the top surface of the medicine bottle 300 can abut against the bottom surface of the first groove 21231, which is favorable for stable placement of the medicine bottle 300.

In some embodiments, as shown in fig. 9, the rubber pad part 2123 has a first through hole 21232, the first through hole 21232 is coaxial with the first groove part 21231 and the cover 20, the first through hole 21232 communicates with the first groove part 21231, and a cross-sectional area of the first through hole 21232 in a plane perpendicular to the second axis m2 of the cover 20 is smaller than a cross-sectional area of the first groove part 21231 in a plane perpendicular to the second axis m2 of the cover 20, for example, an inner diameter of the first through hole 21232 is smaller than an inner diameter of the first groove part 21231. The first through hole 21232 is a part of the through hole 23 penetrating the lid body 20. Fig. 10 is a cross-sectional view of fig. 3 in another embodiment, as shown in fig. 10, a medicine bottle 300 containing a radiopharmaceutical is accommodated in the accommodating groove 13 of the container body 10, and specifically, a cylindrical body below the neck of the medicine bottle 300 is accommodated in the third accommodating space 133. When the push-pin assembly 200 of the injection system can be inserted into the medicine bottle 300 through the through hole of the cap 20, the liquid guiding pin of the push-pin assembly 200 can be inserted into the medicine bottle 300 through the first through hole 21232. Thus, under the condition that the medicine bottle 300 containing the radioactive medicines is positioned in the radiation-proof container 100, the medicine bottle 300 is connected into an injection system, so that the contact between medical personnel and the radioactive medicines is reduced, and the radiation protection is provided for the medical personnel.

Fig. 11 is a schematic structural view of a medicine bottle provided in some embodiments of the present disclosure, fig. 12 is a schematic structural cross-sectional view of a medicine bottle provided in some embodiments of the present disclosure, and fig. 13 is a schematic structural top view of a medicine bottle provided in some embodiments of the present disclosure. As shown in fig. 11-13, the medicine bottle 300 includes a medicine bottle body 301, a glue cap 302, and a packing cap 303. The medicine bottle body is, for example, a glass bottle body, which may be a V-shaped bottle as shown in fig. 12, that is, the bottom of the cavity in the medicine bottle body is substantially V-shaped, and the medicine bottle, for example, a penicillin bottle, is used for holding radioactive medicines, for example, radioactive glass microspheres. When the medicine bottle is connected into an injection system, the radioactive glass microspheres in the medicine bottle can be uniformly discharged from the medicine bottle under the impact of medical liquid. The rubber cover 302 is buckled at the opening of the medicine bottle body 301 and used for closing the medicine bottle body 301. And the packaging cover is provided with an opening 3031, the packaging cover 303, such as an aluminum cover, covers and locks the peripheral region of the rubber cover 302 on the medicine bottle body 301, and the opening 3031 exposes the middle part of the rubber cover 302.

As shown in fig. 7 to 13, the shape and size of the cross section of the first through hole 21232 in the plane perpendicular to the second axis m2 of the cover 20 are substantially the same as those of the opening 3031, for example, both of them are circular and have substantially the same diameter. In response to the cover 20 being fastened to the container body 10, the top surface of the sealing cover 303 abuts against the bottom surface of the first groove 21232, and the projection of the first through hole 3031 on the sealing cover 303 substantially coincides with the opening 3031. Thereby facilitating the liquid guiding needle of the needle pushing assembly 200 to penetrate through the first through hole 21232 into the middle portion of the rubber cover 302 of the medicine bottle 300 exposed by the sealing cover 303 and enter into the medicine bottle 300 when the needle pushing assembly 200 in the injection system can penetrate through the through hole of the cover body 20 and into the medicine bottle 300.

Fig. 14 is an exploded cross-sectional view of the cover of fig. 7. As shown in fig. 14, the protruding portion 21 includes a cushion portion 2123 and a hard portion 213 detachably connected to the cushion portion 2123. The sidewall of the hard portion 213 is provided with a locking groove 2131, and the end of the rubber pad portion 2123 close to the cover body 22 is provided with an engaging portion 21233 matched with the locking groove 2131. For example, the engaging portion of the cushion portion encloses a second groove portion 21234, and the hard portion 213 is received in the second groove portion 21234 away from the top of the cap body. The rubber pad portion 2123 can be attached to the end of the hard portion 213 by engaging the engaging groove 2131 with the engaging portion 21233, thereby forming the protrusion portion 21. The sidewall of the rubber pad portion 2123 and the sidewall of the hard portion 213 are smoothly transited, for example, the sidewall of the rubber pad portion 2123 and the sidewall of a portion of the hard portion 213 far away from the cover body 22 jointly form a same rotational arc surface. The cushion portion 2123 and a portion of the hard portion 213 away from the cover body 22 constitute a second convex portion 212, and a portion of the hard portion 213 close to the cover body 22 serves as a first convex portion 211.

In some embodiments, referring to fig. 7, 10 and 14, the locking groove 2131 is disposed on the outer periphery of the side wall of the hard portion and has a continuous ring shape, and accordingly, the locking portion 21233 on the rubber pad portion 2123 also has a continuous ring shape.

In some embodiments, the locking groove 2131 may be in a discontinuous ring shape, for example, a plurality of spaced locking grooves are disposed on the outer circumference of the sidewall of the hard portion, and correspondingly, the locking portion 21233 on the rubber pad portion 2123 is also in a discontinuous ring shape, for example, a plurality of spaced locking portions are disposed on the circumference of the rubber pad portion.

Referring to fig. 7-14, similar to the embodiments corresponding to fig. 1-6, in these embodiments, the accommodating groove 13 includes a first accommodating space 131, a second accommodating space 132, and a third accommodating space 133 adjacent to and next to the bottom of the accommodating groove, wherein the third accommodating space 133 is configured to accommodate at least a portion of a vial 300 containing a radiopharmaceutical.

The first sidewall 1311 of the first accommodating space 131 extends along a first direction, for example, a vertical direction Y, the first direction is parallel to the first axis m1 of the container body 10, the second sidewall 1321 of the second accommodating space 132 gradually converges from an end of the first sidewall 1311 close to the second accommodating space 132 to the first axis m1 of the container body 10 along the first direction, and the third sidewall 1331 of the third accommodating space 133 extends along the first direction from an end of the second sidewall 1321 far away from the first accommodating space 131.

When the cover 20 is snapped onto the container body 10, the first protrusion 211 and the second protrusion 212 are respectively received in the first receiving space 131 and the second receiving space 132, the first outer sidewall 1311 is in matching fit with the first sidewall 2111, and the second sidewall 1321 is in matching fit with at least a portion of the second outer sidewall 2121, such that the first axis m1 and the second axis m2 are substantially collinear. The inner side wall of the accommodating groove in the container body and the outer side wall of the protruding portion of the cover body are in specific shapes matched with each other, so that when the cover body is buckled on the container body, the first axis of the container body and the second axis of the cover body are basically collinear, the cover body and the container body are aligned and buckled, and the situation that large deviation exists in the horizontal direction when the cover body is buckled with the container body is avoided. In combination with the foregoing, the first trough portion receives the top portion of the vial within the container such that the axis of the cap is substantially collinear with the axis of the vial, in which case the axes of the cap, container body, and vial are substantially collinear. So can be so when the medicine bottle that will be equipped with radiopharmaceutical in follow-up inserts injection system, push away after the needle subassembly inserts the through-hole on the lid can align with the medicine bottle of the holding radiopharmaceutical in the storage tank basically to the realization is located under the condition of the container of protecting against radiation at the medicine bottle of holding radiopharmaceutical, will medicine bottle access injection system has reduced medical personnel and radiopharmaceutical's contact, supplies radiation protection for medical personnel.

Referring to fig. 5,7-14, similar to the embodiments of fig. 1-6, in these embodiments, the container body 10 includes an outer body 11 and an inner body 12. The outer body is provided with a first containing groove 111 with an opening, the inner body 12 is detachably contained in the first containing groove 111, and the inner body 12 is provided with a second containing groove 121 with an opening. When the inner body 12 is mounted in the first receiving groove 111 of the outer body 11, the second receiving groove 121 includes the second receiving space 132 and the third receiving space 133, and the space from the top of the inner body 12 to the top of the outer body 11 in the first receiving groove 111 constitutes the first receiving space 131.

In some embodiments, the material of the outer body is lead, and the material of the inner body is organic glass, when the radioactive drug is radioactive glass microsphere, it produces high energy beta decay, and the beta ray can release strong bremsstrahlung radiation when hitting on the element with large atomic number. The beta ray protection is firstly to use low Z material. Therefore, the inner body material is organic glass made of a low-Z material, and bremsstrahlung of the radioactive glass microspheres is reduced.

Fig. 15 is a schematic diagram of an injection system according to some embodiments of the present disclosure, and as shown in fig. 15, an injection system 1000 for injecting a radiopharmaceutical, such as a radioactive microsphere, into a patient includes, for example, a container 100 for storing a vial of the radiopharmaceutical, a needle pushing assembly 200, a medical fluid bag 400, such as a saline bag, a syringe 500, a waste fluid recovery container 600, and a patient-end retention needle 700.

When performing an injection operation, the push needle assembly 200 is inserted into a vial containing a radiopharmaceutical in the container 100, a syringe is used to draw the physiological saline in the medical fluid bag 400 into the syringe, then a push rod of the syringe is pushed to inject the physiological saline into the vial containing the radiopharmaceutical through the push needle assembly at high pressure, the push needle assembly has a double-needle structure, for example, and includes a fluid inlet needle and a fluid outlet needle, the radioactive drug in the vial is sufficiently impacted by the high-pressure fluid output from the fluid inlet needle, and is discharged out of the vial through the fluid outlet needle under the driving of the fluid, and is injected into a patient through the patient end retention needle 700. When the pressure of the saline pushed by the syringe is too high, the saline enters the waste liquid recovery container 600 through the pressure release valve, so that the pressure in the medicine bottle is prevented from being too high.

In some embodiments, the container 100 of the radiopharmaceutical vial is, for example, the container 100 of the previous embodiments, and in the following description, the container 100 of the corresponding embodiment of fig. 7 is described.

Fig. 16 is a schematic diagram of a push-pin assembly according to some embodiments of the present disclosure, and referring to fig. 7, 10, and 14-16, an injection system 1000 includes a container 100 for holding a vial 300 of radiopharmaceutical, a push-pin assembly 200, a medical fluid bag 400, such as a physiological saline bag, a syringe 500, a waste fluid recovery container 600, and a patient-end retention pin 700.

The container 100 includes a container 100 including a container body 10 and a lid 20, and when the lid 20 is engaged with the container body 10, a relatively closed space is formed inside the container 100. In some embodiments, the container body 10 and the cover 20 may be made of a radiation-proof material, such as lead, so that the container 100 may be used for accommodating a vial containing a radiopharmaceutical, such as a vial. An open receiving groove 13 is provided in the container body 10, and the receiving groove 13 is configured to receive at least a portion of the vial 300 containing the radiopharmaceutical. The cover 20 includes a cover body 22 and a protrusion 21 extending from the bottom of the cover body 22 in a direction away from the top of the cover body 22, and the protrusion 21 is configured to abut against the top of the medicine bottle 300 when the cover 20 is fastened to the container body 10, so that the medicine bottle 300 is fixed in position in the container body 100. The boss portion 21 includes, for example, a rubber pad portion 2123 at an end thereof remote from the cover body 22. With this arrangement, breakage of the medicine bottle can be avoided when the projection 21 abuts against the medicine bottle 300. The lid body 20 has a through hole 23 penetrating the lid body 22 and the boss portion 21.

The push-pin assembly 200 is configured to be inserted into the through hole 23 to be connected with the cover body 20 in a snap-fit manner, and the push-pin assembly 200 includes a cannula 201 and a drainage guide needle assembly 202. At least a part of the drainage needle assembly is disposed in the cannula 201 and configured to be slidable relative to the cannula 201, so that the drainage needle assembly 202 is inserted into the medicine bottle 300, a first engaging portion 231 is disposed on an inner sidewall of the through hole 23, and a second engaging portion 2011 matched with the first engaging portion is disposed on a sidewall of the cannula 301 to engage with the first engaging portion, so that the plunger assembly 200 is locked in the through hole 23.

Fig. 17 is an enlarged view of the region M in fig. 10, and as shown in fig. 10/16 and 17, the first engaging portion 231 includes a first groove 2311, an engaging piece 2313 and an elastic component 2312.

The first groove 2311 is provided on an inner side wall of the through hole, and the extending direction of the first groove 2311 is, for example, perpendicular to the axis of the cover body 20, i.e., the second axis m2. In some embodiments, first groove 2311 may be, for example, a rectangular groove, and in other embodiments, may also be an annular groove around the axis of cap 20. A catch 2313 is slidably disposed in the first groove 2311. One end of the elastic member 2312 is fixedly connected to the bottom of the first groove 2311, the other end of the elastic member 2312 is fixedly connected to the engaging piece 2313, and at least a part of the engaging piece 2313 protrudes out of the inner side wall of the through hole 23 under the action of the elastic member 2312, such as a spring.

The second engaging portion 2011 includes a second groove, hereinafter referred to as a second groove 2011, disposed on a sidewall of the push pin assembly, and when the push pin assembly 200 is inserted into the through hole 23 and is inserted into the predetermined depth, the second groove 2011 receives the at least a portion of the engaging member 2313 and engages with the first engaging portion 231.

In this case, the needle pushing assembly 200 is locked in the through hole 23 of the cap 20, and the liquid guiding needle thereof is inserted into the medicine bottle 300 in the container 100, so that when the medical staff uses the injection system 1000 to inject the radiopharmaceutical into the patient, the needle pushing assembly 200 is prevented from moving or even being separated from the medicine bottle 300 and the through hole, thereby ensuring the smooth operation of the injection operation.

In some embodiments, the engaging member 2313 comprises a first surface 23131 and a second surface 23132 which are sequentially away from the top surface of the cover 20, wherein both the first surface 23131 and the second surface 23132 are inclined relative to the second axis m2 of the cover 20, and the dotted line in fig. 17 is parallel to the second axis m2 of the cover 20. The first surface 23131 and the second surface 23132 gradually approach each other in a direction away from the bottom of the first groove 2311, the second locking groove 2011 comprises a first inner surface 20111 and a second inner surface 20112, and when the at least one part of the clamping piece 2313 enters the second groove 2011 to be clamped with the second groove 2011, the first inner surface 20111 and the second inner surface 20112 are respectively matched and attached with the first surface 23131 and the second surface 23132. By adopting the design, the pin assembly 200 can be inserted into the groove 23 of the cover body 20 and locked, and the pin assembly 200 can be conveniently pulled out from the groove 23 of the cover body 20. After the radiopharmaceutical is injected, the needle assembly is typically discarded due to contamination with the radiopharmaceutical. The container 100 and the lid 20 thereof are relatively expensive to manufacture and can be reused.

In some embodiments, a first angle α between the first surface 23131 and a second axis m2 of the cap 20 (shown in phantom lines parallel to the second axis m2 in fig. 17) is less than a second angle β between the second surface 23132 and the second axis m2 of the cap 20. In this case, a small force is required to push the push pin assembly 200 into the through-hole 23. During the process of pushing the push-pin assembly 200 into the through hole 23, the outer side of the sleeve 201 abuts against the first surface of the engaging member 2313, the engaging member 2313 is pressed into the first groove 2311, and when the second groove 2011 on the side wall of the sleeve 201 is substantially aligned with the first recess 2311, the engaging member 2313 is clamped into the second groove 2011 under the action of the elastic member 2312, so that the push-pin assembly 200 is locked with the cover 20. When the push pin 200 needs to be pulled out of the through hole 23, an operator needs to apply a large force, the second inner surface 20112 of the second notch 2011 applies a component force to the second surface 23132 of the engaging member 2313, the component force faces the bottom of the first groove 2311, so that the engaging member 2313 moves towards the bottom of the first groove 2311, and the first engaging portion 231 is separated from the second engaging portion 2011.

In some embodiments, as shown in fig. 16, the second engaging portion 2011 is, for example, a circumferential annular groove.

In some embodiments, at least one of the first surface 23131 and the second surface 23132 of the engaging element 2313 is an arc surface, and the second locking groove 2011 includes a first inner surface 20111 and a second inner surface 20112 which may also be a matching arc surface.

In some embodiments, as shown in fig. 7, 10, 14-16, the inner sidewall of the through hole 23 includes a step-shaped limiting portion 232, the step portion 232 is located on a side of the first groove 231 close to the top surface of the cover, the sleeve 201 further includes a protruding portion 2012 extending in a direction away from the axis of the sleeve, and the limiting portion 232 is configured to abut against the protruding portion 2012 during the insertion of the push-pin assembly into the through hole 23 to limit the push-pin assembly 200. In some embodiments, the top surface of the position-limiting portion 232 is a plane, and the top surface is perpendicular to the second axis m2 of the cover body.

Referring to fig. 7, 10, and 14-16, the liquid guide needle assembly 202 includes: a slider 2021 and a liquid guide needle 2022. The liquid guiding needle 2022 is fixedly connected with the sliding member 2021, and at least a part of the liquid guiding needle 2022 is disposed in the sliding member 2021. A convex portion 20211 is disposed on a side wall of the slider 2021, a sliding slot 2013 extending along a length direction of the sleeve is disposed on a side wall of the sleeve 201, the convex portion 20211 is slidably accommodated in the sliding slot 2013, and the slider 2021 further includes a handle portion 20212 extending from a side wall of the convex portion 20211 exposed by the sliding slot away from the convex portion. When an external force is applied to the handle portion 20212, the slider 2021 can slide in the extending direction of the slide groove 2013, and the length of the slide groove 2013 defines the distance by which the slider 2021 can slide.

In some embodiments, the protrusions are provided in pairs and are disposed opposite to each other, the corresponding chutes 2013 are provided in pairs and are also disposed opposite to each other, and the handle portions 20212 are provided in pairs and are also disposed opposite to each other.

Fig. 18 is a schematic cross-sectional view of the region N in fig. 16, and as shown in fig. 16 and 18, in some embodiments, a first locking groove 202113 is formed on a side wall of the protrusion 20211 facing the corresponding sliding groove, and an elastic protrusion 20131 matching with the first locking groove is formed on an inner side wall of the sliding groove 2013, and when the sliding member 2021 slides to an end of the sliding groove 2013 far away from the top of the sleeve, the elastic protrusion 20131 is engaged with the first locking groove 202113. In this case, the needle pushing assembly 200 is locked in the through hole 23 of the cap 20, and the liquid guiding needle thereof is inserted into the medicine bottle 300 in the container 100, so that when the medical staff uses the injection system 1000 to inject the radiopharmaceutical into the patient, the liquid guiding needle assembly 202 is prevented from moving relative to the guide tube 201, and the smooth operation of the injection operation is ensured.

In some embodiments, the number of the first catching grooves and the elastic protrusions may be 2 or more.

In some embodiments, as shown in fig. 16, the chute 2013 extends from the top of the cannula 201 along the length of the cannula away from the top of the cannula, and the push-pin assembly 200 further comprises a top plug 203 that is removably mounted on the top of the cannula 201 such that the end of the chute 2013 at the top of the cannula is closed. In this case, the introducer needle assembly 202 may be removed from cannula 201 by removing a top plug at the top of cannula 201 to facilitate replacement of introducer needle assembly 202.

In some embodiments, as shown in fig. 10 and 16, the number of the protrusions 20211 of the slider 2021 is two, for example, the first protrusion 202111 and the second protrusion 202112 are oppositely disposed, and the liquid guide needle 2022 has a double-needle structure and includes a liquid inlet needle 20221 and a liquid outlet needle 20222.

In some embodiments, the liquid inlet needle 20221 includes a first sub-portion 202211 and a second sub-portion 202212 connected to each other, the first sub-portion 202211 extends in a direction away from the slider through a side wall of the first protrusion 202111 exposed by the sliding groove, the second sub-portion 202212 extends in the sleeve extending direction through a bottom surface of the slider, and a connecting portion of the first sub-portion 202211 and the second sub-portion 202212 is located in the slider; the liquid outlet needle 20222 includes a third sub-portion 202221 and a fourth sub-portion 202222 which are connected with each other, the third sub-portion 202221 passes through the side wall of the second protrusion 202112 exposed by the sliding groove and extends in a direction away from the sliding member, the fourth sub-portion 202222 passes through the bottom surface of the sliding member and extends in the sleeve extending direction, and a connecting portion of the third sub-portion 202221 and the fourth sub-portion 202222 is located in the sliding member.

In some embodiments, the second sub-portion 202212 is disposed parallel to the fourth sub-portion 202222, and the first sub-portion 202211 is disposed parallel to the third sub-portion 202221 and extends in opposite directions.

In some examples, as shown in fig. 10 and 16, the cannula 201 includes a first sub-cannula 2014 and a second sub-cannula 2015. The slide 2021 is disposed in the first sub-sleeve. The second sub-sleeve 2015 is adjacent to the first sub-sleeve 2014 and comprises two parallel pipelines respectively accommodating the second sub-portion 202212 of the liquid inlet needle 20221 and the fourth sub-portion 202222 of the liquid outlet needle 20222. When the convex portion 20211 of the sliding member 2021 slides from the end of the sliding groove close to the top of the sleeve to the end of the sliding groove far from the top of the sleeve, the second sub-portion 202212 of the liquid inlet needle 20221 and at least a portion of the fourth sub-portion 202222 of the liquid outlet needle 20222 extend from the two pipelines to penetrate through the through hole 23 and be inserted into the medicine bottle 300.

In some embodiments, as shown in fig. 10, the distance between the liquid outlet of the liquid inlet needle 20221 and the inner bottom surface of the medicine bottle 300 relative to the liquid inlet of the liquid outlet needle 20222 may be the same or different, and when there are radioactive particles in the medicine bottle 300, the liquid outlet of the liquid inlet needle 20221 is closer to the inner bottom surface of the medicine bottle 300 relative to the liquid inlet of the liquid outlet needle 20222, that is, the liquid outlet of the liquid inlet needle 20221 is farther from the sliding member 2021 relative to the liquid inlet of the liquid outlet needle 20222.

In the foregoing embodiment, the push pin assembly of the parallel double-pin structure of the liquid inlet pin and the liquid outlet pin is taken as an example for explanation, in other embodiments, the liquid inlet pin and the liquid outlet pin may be integrated on a single pin body, for example, a liquid inlet passage and a liquid outlet passage are provided inside the single pin body, a liquid outlet of the liquid inlet passage and a liquid inlet of the liquid outlet passage are provided on a side wall of an end portion of the single pin body, a distance from a liquid outlet of the liquid inlet passage to an inner bottom surface of the medicine bottle 300 relative to a liquid inlet of the liquid outlet passage may be the same or different, and when there are radioactive particles in the medicine bottle 300, a liquid outlet of the liquid inlet passage is closer to the inner bottom surface of the medicine bottle 300 relative to a liquid inlet of the liquid outlet passage.

Some embodiments of the present disclosure also provide for the use of a container, such as the container described in the previous embodiments, for holding a vial of radiopharmaceutical.

Finally, it should be noted that: the embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The system or the device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.

The above examples are only intended to illustrate the technical solutions of the present disclosure, not to limit them; although the present disclosure has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present disclosure.

Claims

1. A container for holding a vial of radiopharmaceutical, said container comprising:

the first groove portion receives the top of the vial in response to the cap being snapped onto the container body such that an axis of the cap is substantially collinear with an axis of the vial,

the rubber pad part is provided with a first through hole which is coaxial with the first groove part and the cover body, the first through hole is communicated with the first groove part, the cross-sectional area of the first through hole in the plane vertical to the axis of the cover body is smaller than that of the first groove part in the plane vertical to the axis of the cover body,

the accommodating groove comprises a first accommodating space, a second accommodating space and a third accommodating space which are sequentially close to the bottom of the accommodating groove and are sequentially adjacent, and the third accommodating space is configured to accommodate at least one part of the medicine bottle;

in response to the lid being snapped onto the container body, the first and second protrusions are received in the first and second receiving spaces, respectively, the first outer sidewall is in mating engagement with the first sidewall, and the second sidewall is in mating engagement with at least a portion of the second outer sidewall such that the axis of the container body is substantially collinear with the axis of the lid,

the container body includes:

2. The container of claim 1, wherein the side wall of the first slot portion is arcuate in shape in a cross section through an axis of the lid, convex toward the axis.

3. The container of claim 1 or 2, wherein the bottom surface of the first groove portion has a shape and size substantially the same as the top surface of the medicine bottle.

4. The container of claim 1, wherein the vial comprises:

a vial body configured to hold a radiopharmaceutical;

the rubber cover is buckled at the opening of the medicine bottle body; and

5. The container according to claim 1 or 2, wherein the protrusion further comprises a hard portion detachably connected to the rubber pad portion, wherein a clamping groove is formed in a side wall of the hard portion, and a clamping portion matched with the clamping groove is formed at an end portion of the rubber pad portion close to the cover body.

6. The container according to claim 5, wherein the catching groove is provided on the outer circumference of the side wall of the hard portion in a continuous or discontinuous ring shape.

7. The container of claim 6, wherein the snap-fit portion of the cushion portion encloses a second slot portion in which the hard portion is received away from the top of the lid body.

8. The container of claim 1, wherein the material of the outer body is primarily at least one or a combination of lead, lead alloy, or tungsten alloy, and the material of the inner body is primarily at least one or a combination of lead, lead alloy, tungsten, or an organic polymer material.

9. Use of a container for receiving a vial containing a radiopharmaceutical, said container being as claimed in any one of claims 1 to 8.