CN114796843A - Medical ultrasonic penetration device - Google Patents

Medical ultrasonic penetration device Download PDF

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Publication number
CN114796843A
CN114796843A CN202210629960.9A CN202210629960A CN114796843A CN 114796843 A CN114796843 A CN 114796843A CN 202210629960 A CN202210629960 A CN 202210629960A CN 114796843 A CN114796843 A CN 114796843A
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CN
China
Prior art keywords
piezoelectric ceramic
cover plate
sheet
front cover
piece
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Pending
Application number
CN202210629960.9A
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Chinese (zh)
Inventor
姜涛
杨金涛
皮钧
罗文宇
梁哲铭
沈志煌
侯达盘
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Jimei University
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Jimei University
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Publication date
Application filed by Jimei University filed Critical Jimei University
Priority to CN202210629960.9A priority Critical patent/CN114796843A/en
Publication of CN114796843A publication Critical patent/CN114796843A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Abstract

The invention provides a medical ultrasonic infiltration device, comprising: the device comprises at least one piezoelectric ceramic piece, a pair of insulation pieces, a pair of electrode pieces, a front cover plate, a rear cover plate and three hydrogel patches, a silica gel piece, a fixing plate, a battery and an integrated power amplifier. The invention provides a novel medical ultrasonic penetration device, which can obviously improve the percutaneous penetration performance of medicaments through low-frequency ultrasonic waves, accelerate the absorption of human bodies to medicaments for external use, such as plaster and the like, and increase the medicament utilization rate. And the device has the characteristics of simple structure and remarkable effect.

Description

Medical ultrasonic penetration device
Technical Field
The invention relates to the selection and the work of a piezoelectric ceramic piece, in particular to a medical ultrasonic infiltration device which is used for an integrated power amplifier and is matched with the piezoelectric ceramic piece to promote the generation and the transmission of ultrasonic waves to play a role finally.
Background
The most prominent application of low frequency ultrasound is ultrasound therapy. With the progress of science and technology, people pay more attention to their health. However, the environmental pollution is more and more serious, the living environment of human beings is also worse, and diseases appear endlessly in succession. Humans are actively seeking various medical methods and medical means to maintain their health. In recent years, noninvasive medicine is rapidly developed, and human beings use means such as sound, light, electricity, magnetism and the like to perform noninvasive or minimally invasive treatment on various diseases, so that good effects are achieved. Due to the good penetrability and thermal effect of ultrasonic waves, the ultrasonic waves are more and more widely applied to various fields of pain relief, drug absorption, human tissue welding and excision, broken bone connection, disease diagnosis and the like. Sonophoresis is an important permeation-promoting method for transdermal drug delivery, and mainly acts on skin tissues through thermal effect, acoustic streaming effect, mechanical effect and cavitation effect to generate biological effect, so as to achieve the purpose of treating diseases, wherein the cavitation effect is considered as the most main mechanism of sonophoresis. The piezoelectric ceramic piece is an electronic sound producing element, a piezoelectric ceramic dielectric material is placed between two copper round electrodes, and when an alternating current audio signal is connected to the two electrodes, the piezoelectric piece can vibrate according to the magnitude frequency of the signal to produce corresponding sound.
Disclosure of Invention
The present invention is directed to medical applications for increasing the delivery of steroidal anti-inflammatory drugs, such as topical therapeutic hydrocortisone and the like. The medical ultrasonic penetration device overcomes low permeability of skin, improves the percutaneous penetration performance of the medicine and accelerates the absorption of the human body to the medicine for external use by using the low-frequency ultrasonic wave.
The invention is provided with at least one piezoelectric ceramic piece, a pair of insulation pieces, a pair of electrode plates, a front cover plate, a rear cover plate, three hydrogel patches, a silica gel piece, a fixing plate, a battery, an integrated power amplifier and a shell; the piezoelectric ceramic piece is connected with the silica gel piece through a fixing plate, three hydrogel patches are embedded at two ends and the middle part of the silica gel piece, the fixing plate is connected with the front cover plate through a spherical column, the front cover plate is connected with the front cover plate through an epoxy resin adhesive and a coupling agent in the arrangement sequence of an insulating sheet-an electrode sheet-the piezoelectric ceramic piece-an electrode sheet-an insulating sheet, the upper electrode sheet and the lower electrode sheet are respectively connected with the connection positions of the positive electrode and the negative electrode of an integrated power amplifier, the integrated power amplifier converts the current in a battery into electric power and transmits the electric power into the piezoelectric ceramic piece, the piezoelectric ceramic piece converts the input electric power into mechanical power (namely ultrasonic wave), and then the low-frequency ultrasonic wave is transmitted to a cortical layer.
Furthermore, the number of the piezoelectric ceramic pieces is set according to the required frequency.
Furthermore, the vibration output end (the assembly of the piezoelectric ceramic piece) adopts the arrangement sequence of the insulation piece-electrode piece-piezoelectric ceramic piece-electrode piece-insulation piece to realize the fixation between the vibration output end and the front cover plate and the connection between the vibration output end and the front cover plate by using an epoxy resin adhesive and a coupling agent, so that the piezoelectric ceramic piece can better receive vibration signals and carry out safety protection. The piezoelectric ceramic chip structure can be connected with the front cover plate through an epoxy resin adhesive and is connected with the fixing plate through a spherical column and the adhesive in a matched mode.
Furthermore, the hydrogel patches are symmetrically distributed at the two ends and the middle part of the silica gel sheet, so that the hydrogel patches can be attached to the positions of the human body where the external medicine is used, and the device does not need to be designed according to the diameter of the used positions. The silica gel sheet is adhered with the human epidermis through the hydrogel patch, and the physiological saline is used as a coupling agent after the medicine part is adhered.
Furthermore, the piezoelectric ceramic plate is connected with the spherical ball column of the fixing plate through the track hole of the front cover plate, and the assembly is tight, so that the ultrasonic wave can be efficiently transmitted to the epidermis of a human body.
Furthermore, the rear cover plate is connected with the insulating plate, the integrated power amplifier and the battery are embedded on the rear cover plate, and the connecting wire is also adhered to the shell, so that the integrated power amplifier, the battery and the connecting wire are prevented from falling off in the vibration process.
Drawings
FIG. 1 is an isometric front view of an embodiment of the invention.
Fig. 2 is an exploded view of an embodiment of the present invention.
FIG. 3 is an isometric front view of a stationary portion of an embodiment of the invention.
FIG. 4 is an isometric front view of an ultrasound generating portion of an embodiment of the invention.
Fig. 5 is an isometric front view of a power output section of an embodiment of the invention.
The code numbers of the main components in FIGS. 1-5 are given below:
1-silica gel sheet, 2-hydrogel patch, 3-fixing plate, 4-front cover plate, 5-electrode plate, 6-insulation sheet, 7-piezoelectric ceramic sheet, 8-rear cover plate, 9-battery, 10-integrated power amplifier and 11-shell.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "circumferential", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be considered as limiting the present invention. In the present invention, unless otherwise expressly specified or limited, the terms "disposed," "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected or detachably connected; may be a mechanical connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.
As shown in fig. 1 to 5, the embodiment of the invention is provided with a silica gel sheet 1, a hydrogel patch 2, a fixing plate 3, a front cover plate 4, an electrode plate 5, an insulating sheet 6, a piezoelectric ceramic sheet 7, a rear cover plate 8, a battery 9, an integrated power amplifier 10 and a housing 11.
The silicon sheet 1 and the fixing plate 3 are fixedly installed through a spherical column, the hydrogel patches 2 are symmetrically adhered to two ends and the middle of the silicon sheet 1, the front cover plate 4 and the fixing plate 3 are connected with an epoxy resin adhesive in a matched mode through the spherical column, the insulating sheet 6-electrode sheet 5-piezoelectric ceramic sheet 7-electrode sheet 5-insulating sheet 6-rear cover plate 8 are installed in a matched mode through the epoxy resin adhesive and a coupling agent, the battery 9 and the integrated power amplifier 10 are installed on the upper surface of the rear cover plate 8, the integrated power amplifier 10 is connected with the positive electrode and the negative electrode of the battery 9 through wiring, and the electrode sheet 5 is also connected through wiring. And finally, the shell is connected with the front cover plate through threads. The number of the piezoelectric ceramic pieces is set according to the required frequency.
The vibration output end (the assembly of the piezoelectric ceramic piece) adopts the arrangement sequence of the insulation piece-electrode piece-piezoelectric ceramic piece-electrode piece-insulation piece to realize the fixation between the vibration output end and the front cover plate and the connection between the vibration output end and the front cover plate by using an epoxy resin adhesive and a coupling agent, so that the piezoelectric ceramic piece can better receive vibration signals and carry out safety protection. The piezoelectric ceramic chip structure can be connected with the front cover plate through an epoxy resin adhesive and is connected with the fixing plate through a spherical column and the adhesive in a matched mode.
The hydrogel patches are symmetrically distributed at the two ends and the middle part of the silica gel sheet, so that the hydrogel patches can be attached to the positions of a human body where the external medicine is used, and a device does not need to be designed according to the diameter of the used positions. The silica gel sheet is adhered with human epidermis through hydrogel patch, and the medicine part is adhered with normal saline as coupling agent.
The piezoelectric ceramic piece is connected with the spherical ball column of the fixing plate through the track hole of the front cover plate, and the piezoelectric ceramic piece is tightly assembled to enable ultrasonic waves to be efficiently transmitted to the epidermis of a human body.
The back cover plate is connected with the insulating plate, the integrated power amplifier and the battery are embedded on the back cover plate, and the wiring is bonded on the shell, so that the integrated power amplifier, the battery and the wiring are prevented from falling off in vibration.
When ultrasonic penetration is carried out, firstly, the silica gel sheet 1 is fixed at the using part of the external medicine, and then the anode and the cathode of the battery 9 are connected with the integrated power amplifier 10 through wiring to transmit electric signals; the integrated power amplifier 10 converts the electric signal into electric power and transmits the electric power to the piezoelectric ceramic piece 7 through the wiring and the electrode plate 5, the piezoelectric ceramic piece 7 converts the electric power into low-frequency ultrasonic waves, and finally the low-frequency ultrasonic waves are transmitted to a human body cortical layer through the front cover plate 4 to complete the whole process of ultrasonic penetration, and the setting switch and the power adjusting device of the rear cover plate 8 can control the frequency of the ultrasonic waves generated by the piezoelectric ceramic piece.
According to different required frequencies, the piezoelectric ceramic plates 7 can be converted into a plurality of piezoelectric ceramic plates such as 2 piezoelectric ceramic plates, 3 piezoelectric ceramic plates and the like which are connected in series for use.
The above description is only for the specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims (6)

1. A medical ultrasound infiltration device characterized by: the device comprises at least one piezoelectric ceramic piece, a pair of insulation pieces, a pair of electrode pieces, a front cover plate, a rear cover plate, three hydrogel patches, a silica gel piece, a fixing plate, a battery, an integrated power amplifier and a shell; the piezoelectric ceramic piece is connected with the silica gel piece through a fixing plate, three hydrogel patches are embedded at two ends and the middle part of the silica gel piece, the fixing plate is connected with the front cover plate through a spherical column, the front cover plate is connected with the front cover plate through an epoxy resin adhesive and a coupling agent in the arrangement sequence of an insulating sheet-electrode sheet-piezoelectric ceramic piece-electrode sheet-insulating sheet, the upper electrode sheet and the lower electrode sheet are respectively connected with the connection positions of the positive electrode and the negative electrode of an integrated power amplifier, the integrated power amplifier converts the current in a battery into electric power and transmits the electric power into the piezoelectric ceramic piece, the piezoelectric ceramic piece converts the input electric power into mechanical power, and then the low-frequency ultrasonic wave is transmitted to a cortical layer, so that the percutaneous permeability of the medicine can be obviously improved, and the absorption of a human body to the externally-applied medicine is accelerated.
2. The medical ultrasound infiltration apparatus of claim 1, wherein: the number of the piezoelectric ceramic pieces is set according to the required frequency.
3. The medical ultrasound infiltration apparatus of claim 1, wherein: the vibration output end is connected with the front cover plate by using an epoxy resin adhesive and a coupling agent in the sequence of insulating sheet-electrode sheet-piezoelectric ceramic sheet-electrode sheet-insulating sheet, so that the piezoelectric ceramic sheet can better receive vibration signals and carry out safety protection.
4. The medical ultrasound infiltration apparatus of claim 1, wherein: the hydrogel patches are symmetrically distributed at the two ends and the middle part of the silica gel sheet, so that the hydrogel patches can be attached to the positions of a human body where the external medicine is used, and a device does not need to be designed according to the diameter of the used positions.
5. The medical ultrasound infiltration apparatus of claim 1, wherein: the piezoelectric ceramic piece is connected with the spherical ball column of the fixing plate through the track hole of the front cover plate, and the piezoelectric ceramic piece is tightly assembled to enable ultrasonic waves to be efficiently transmitted to the epidermis of a human body.
6. The medical ultrasound infiltration apparatus of claim 1, wherein: the back cover plate is connected with the insulating plate, the integrated power amplifier and the battery are embedded on the back cover plate, and the wiring is also adhered to the shell, so that the integrated power amplifier, the battery and the wiring are prevented from falling off during vibration.
CN202210629960.9A 2022-06-06 2022-06-06 Medical ultrasonic penetration device Pending CN114796843A (en)

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CN202210629960.9A CN114796843A (en) 2022-06-06 2022-06-06 Medical ultrasonic penetration device

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115624690A (en) * 2022-10-14 2023-01-20 江苏省声学产业技术创新中心 Bowl-shaped piezoelectric ceramic structure for transdermal drug delivery instrument and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2145041Y (en) * 1992-11-28 1993-11-03 张若昕 Leading-in instrument of efficient cosmetic electuary for household
CN103861204A (en) * 2014-03-25 2014-06-18 王安 Modulation ultrasonic wave device and percutaneous administration permeation facilitating method thereof
CN108686915A (en) * 2018-05-17 2018-10-23 广东固特超声股份有限公司 A kind of sonic washing machine
CN209137744U (en) * 2018-03-12 2019-07-23 湖南省健缘医疗科技有限公司 Disposable patch
CN211486210U (en) * 2019-07-23 2020-09-15 李连清 Thermal ultrasonic acupoint medicine-penetrating therapeutic apparatus
CN113842544A (en) * 2021-10-18 2021-12-28 中南大学 Percutaneous permeation-promoting drug delivery device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2145041Y (en) * 1992-11-28 1993-11-03 张若昕 Leading-in instrument of efficient cosmetic electuary for household
CN103861204A (en) * 2014-03-25 2014-06-18 王安 Modulation ultrasonic wave device and percutaneous administration permeation facilitating method thereof
CN209137744U (en) * 2018-03-12 2019-07-23 湖南省健缘医疗科技有限公司 Disposable patch
CN108686915A (en) * 2018-05-17 2018-10-23 广东固特超声股份有限公司 A kind of sonic washing machine
CN211486210U (en) * 2019-07-23 2020-09-15 李连清 Thermal ultrasonic acupoint medicine-penetrating therapeutic apparatus
CN113842544A (en) * 2021-10-18 2021-12-28 中南大学 Percutaneous permeation-promoting drug delivery device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115624690A (en) * 2022-10-14 2023-01-20 江苏省声学产业技术创新中心 Bowl-shaped piezoelectric ceramic structure for transdermal drug delivery instrument and application thereof
CN115624690B (en) * 2022-10-14 2023-10-31 江苏省声学产业技术创新中心 Bowl-shaped piezoelectric ceramic structure for transdermal drug delivery instrument and application thereof

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