Connect public, paid and private patent data with Google Patents Public Datasets

Modulation ultrasonic wave device and percutaneous administration permeation facilitating method thereof

Download PDF

Info

Publication number
CN103861204A
CN103861204A CN 201410112423 CN201410112423A CN103861204A CN 103861204 A CN103861204 A CN 103861204A CN 201410112423 CN201410112423 CN 201410112423 CN 201410112423 A CN201410112423 A CN 201410112423A CN 103861204 A CN103861204 A CN 103861204A
Authority
CN
Grant status
Application
Patent type
Prior art keywords
ultrasonic
modulation
wave
administration
percutaneous
Prior art date
Application number
CN 201410112423
Other languages
Chinese (zh)
Other versions
CN103861204B (en )
Inventor
王安
Original Assignee
王安
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

The invention discloses a modulation ultrasonic wave device and application thereof in the percutaneous administration aspect. The modulation ultrasonic wave device comprises a modulation ultrasonic wave generator and a single-channel multi-frequency ultrasonic wave transducer, wherein the modulation ultrasonic wave generator is used for generating modulation ultrasonic wave stimulation electric signals, and the single-channel multi-frequency ultrasonic wave transducer is used for emitting modulation ultrasonic waves. The modulation ultrasonic waves have a synergistic effect on the permeation facilitating effect of percutaneous administration, and the technical problem that ultrasonic waves are insufficient in permeation facilitating of percutaneous administration. An efficient modulation ultrasonic wave permeation facilitating percutaneous administration method is provided for the pharmaceutical industry.

Description

一种调制超声波装置及其经皮给药的促渗透方法 An ultrasonic apparatus and method for percutaneous administration of the penetration-modulation

技术领域 FIELD

[0001] 本发明属于超声波经皮治疗、诊断和经皮给药医药领域,调制超声波可进一步提高其穿透生物活体皮肤和组织的能力。 [0001] The present invention pertains to an ultrasonic transdermal therapeutic, diagnostic and pharmaceutical field of transdermal administration, the ultrasonic modulation can be further improved its ability to penetrate the skin of the living organism and tissue. 本发明包括一种调制超声波装置及调制超声波对经皮给药的促渗透方法。 The present invention includes an ultrasonic modulating apparatus and a modulation method for the penetration of ultrasonic transdermal administration.

背景技术 Background technique

[0002] 经皮给药(也称为透皮给药)是药物通过皮肤吸收的一种给药方式,药物作用于皮肤,穿过角质层,通过皮肤扩散,由毛细血管吸收进入人体循环。 [0002] The transdermal administration (transdermal administration is also referred to) is achieved by a mode of administration of drug absorbed through the skin, the drug in the skin, through the stratum corneum, diffusion through the skin into the body by a capillary absorption cycle. 与传统给药方式相比,具有避免肝脏首过效应及肠胃灭活、维持恒定的血药浓度或药理效应、提高生物利用度、降低药物的不良反应、尽可能地保持药物的持续释放、患者可以自主用药等特点。 Compared with the traditional mode of administration, the effect of avoiding hepatic and gastrointestinal first pass inactivation, maintaining a constant plasma concentration or pharmacological effect, improve the bioavailability, reduce adverse drug reactions, sustained release of the drug as possible, the patient and so can self-medication. 但是,由于皮肤角质层的屏障作用,大多数药物的透皮性能很差,经皮给药达不到药物的有效治疗血药浓度要求,以至不能实现临床应用。 However, since the barrier function of the stratum corneum, transdermal poor performance of most drugs, the transdermal administration of drugs reach a therapeutically effective blood concentration requirements, as well as clinical application can not be achieved. 所以使用辅助方法提高药物透过皮肤的量,就成了经皮给药的关键。 Therefore, auxiliary transmission method of increasing an amount of drug in the skin, it would be critical for percutaneous administration. 超声波照射皮肤能够明显促进药物的经皮吸收,这种物理方法称之为超声波促渗透,其使用相对安全,皮肤屏障能够很快恢复,药物不会被降解破坏,具有很好的发展前景。 Ultrasonic irradiation of the skin can significantly promote the percutaneous absorption of drugs, such ultrasonic penetration-called physical method, which is relatively safe to use, the skin barrier can be restored quickly, the drug will not be degraded destroyed, having good prospects. 现有的超声波促渗透技术对药物的经皮吸收的促渗透作用较为有限,以致大多数透皮性能差的药物还无法实现临床应用。 Prior art ultrasonic penetration-promoting permeation of the drug for percutaneous absorption is more limited, so that the difference between the performance of most transdermal drug can not achieve clinical application. 本发明公开了调制超声波对经皮给药促渗透效应具有协同作用,为医药行业提供了一种高效促渗透经皮给药方法。 The present invention discloses a synergistic effect with ultrasonic waves modulated on the percutaneous permeation promoting effects of administration, transdermal delivery provides a permeation promoting an efficient method for the pharmaceutical industry.

发明内容 SUMMARY

[0003] 本发明公开了一种调制超声波装置及其经皮给药的促渗透方法。 [0003] The present invention discloses a penetration-modulating apparatus and method for ultrasonic transdermal administration.

[0004] 1.一种调制超声波装置,本发明所采用的技术方案是: [0004] An ultrasonic modulating apparatus aspect of the present invention is employed:

本发明的调制超声波装置`包括产生调制超声波激励电信号的调制超声波发生器和发射调制超声波的超声波换能器,所述的超声波换能器为单通道多频率超声波换能器。 Ultrasonic modulator means' of the invention include generating a modulated ultrasonic generator and an ultrasonic transmit modulation modulated ultrasonic excitation electrical signal of an ultrasonic transducer, the ultrasonic transducer is a single-channel multi-frequency ultrasonic transducer.

[0005] 所述的调制超声波发生器包括中央控制器,与中央控制器连接的开关电路控制单元、参数设定单元、显示单元以及功率放大控制单元,与开关电路控制单元连接的调制器,与开关电路控制单元和中央控制器连接的高频分量单元、中频分量单元以及低频分量单元,还包括与功率放大控制单元连接的高频分量功率放大器、中频分量功率放大器以及低频分量功率放大器;高频分量单元与高频分量功率放大器连接,中频分量单元与中频分量功率放大器连接,低频分量单元与低频分量功率放大器连接,调制器又分别与高频分量功率放大器、中频分量功率放大器和低频分量功率放大器连接。 [0005] The modulation of the ultrasonic generator comprises a central controller, the switching circuit control unit connected to the central controller, the parameter setting unit, a display unit and a power amplification control unit, a modulator circuit connected to the switch control unit, and high-frequency component unit and a central control unit switching circuit connected to the controller, and the intermediate frequency component of the low-frequency component unit means further comprises a power amplification control unit connected to the high frequency components of the power amplifier, the power amplifier and the intermediate frequency component of the low frequency component of the power amplifier; frequency component of the power amplifier unit connected to the high-frequency component, the intermediate frequency component of the power amplifier unit is connected with an intermediate frequency component, low frequency components of the power amplifier unit connected to the low-frequency component, a modulator and power amplifier are high-frequency component, the intermediate frequency component and low frequency component of the power amplifier PA connection.

[0006] 其中,高频分量单元、中频分量单元以及低频分量单元内部分别设置有连续波发生器和脉冲波发生器。 [0006] wherein the high-frequency component unit, the IF frequency component and an internal component of the unit cell are respectively provided with a continuous wave generator and a pulse wave generator. 高频分量频率范围为I~5MHz,中频分量频率范围为200~1000KHz,低频分量频率范围为20~200KHz。 High-frequency component of the frequency range of I ~ 5MHz, the frequency range of the intermediate frequency component of 200 ~ 1000KHz, low frequency components in the frequency range 20 ~ 200KHz.

[0007] 本发明调制超声波装置既含有调频调制成分也包含调幅调制成分,是对三个频率不同和振幅不同电信号加以合成,生成具有一定的关联性调制超声波。 Modulating an ultrasonic device of the invention [0007] The present composition contains both FM modulator also includes AM modulated component, the electrical signal is different for synthesizing three different frequencies and amplitudes, generating a modulated ultrasonic some relevance.

[0008] 所述的单通道多频率超声波换能器采用圆柱形单通道多频率超声波换能器或圆柱梯形单通道多频率超声波换能器。 [0008] The single-channel multi-frequency ultrasound transducer adopts a cylindrical single-channel multi-frequency ultrasonic transducers or ladder cylindrical single-channel multi-frequency ultrasonic transducer. 单通道系指调制超声波幅射方向和路径相同。 Modulation means the same single-channel ultrasonic radiation direction and path. 圆柱形单通道多频率超声波换能器包括外部的支架和内部的填料,三个圆形压电陶瓷平行分布于填料中,分别通过各自的压电陶瓷电极引线与调制器和开关电路控制单元连接。 Cylindrical single-channel multi-frequency ultrasonic transducer comprises a support and an inner packing outside, three circular piezoelectric ceramic filler distributed in parallel, respectively, through the respective piezoelectric ceramic electrode lead modulator and a switching circuit connected to a control unit . 圆柱梯形单通道多频率超声波换能器包括外部的支架和内部的填料,填料中央的腔体一端形成梯形,三个圆环状压电陶瓷分布于腔体一端的梯形阶梯上,分别通过各自的压电陶瓷电极引线与调制器和开关电路控制单元连接。 Trapezoidal cylindrical single-channel multi-frequency ultrasonic transducer comprises a support and an inner packing the external end of the cavity forming a trapezoidal central filler, three piezoelectric ceramic annular distribution chamber on one end of the ladder step, through their respective piezoelectric ceramic electrode lead modulator and a switching circuit connected to the control unit. 最后,通过单通道多频率超声波换能器把调制激励电信号转化成调制超声波。 Finally, by single-channel multi-frequency modulated ultrasonic transducer converts electrical signals into a modulated ultrasonic excitation.

[0009] 2.本发明进一步公开了调制超声波装置在经皮给药促渗透方面的应用,公开了调制超声波对经皮给药的促渗透方法 [0009] 2. The present invention further discloses the use of an ultrasonic modulating means for transdermal administration in terms of promoting penetration, the penetration is disclosed a method of modulating an ultrasonic transdermal administration

设置适当调制超声波参数,包括激励电信号波形,是脉冲波、还是连续波或者是脉冲波与连续波组合成的混合波,高频分量(I~5MHz)、中频分量(200~ΙΟΟΟΚΗζ)、低频分量(20~200ΚΗζ)三个分量的频率具体取值,三个分量的振幅或脉冲幅度和脉冲波占空比取值,调制超声波三个分量的强度取值(强度范围0.05~10 W/cm2)及照射时间取值(照射时间范围0.5分钟至24小时),闻频分量、中频分量、低频分量三个分量相互之间的时间间歇取值(时间间歇范围为高频分量周期时间的I倍至低频分量周期时间的1000倍)。 Provided suitably modulated ultrasonic parameters, including electrical excitation waveform, a pulse wave or continuous wave or pulsed wave and continuous wave combined into a hybrid wave, high frequency components (I ~ 5MHz), the intermediate frequency components (200 ~ ΙΟΟΟΚΗζ), low specific values ​​of the frequency components of the three components (20 ~ 200ΚΗζ), the three components of the amplitude or pulse amplitude and pulse duty cycle values, the intensity values ​​of the three components of the ultrasonic modulation (intensity range of 0.05 ~ 10 W / cm2 ) and the value of the irradiation time (irradiation time ranges from 0.5 to 24 minutes), Wen-frequency component, the intermediate frequency component, a low frequency component of the three components to each other between the time interval value (time interval range I times the cycle time of a high frequency component 1000 times the cycle time of the low-frequency components). 调制超声波的高频分量、中频分量和低频分量各自的持续时间,三个分量各自的持续时间范围为调制超声波周期2~98%。 High-frequency component of the modulated ultrasonic waves, the intermediate frequency and low frequency components of each of a duration, a duration of each of the three components of the modulation range of the ultrasonic period of 2 to 98%. 使用单通道多频率超声波换能器发射调制超声波照射涂抹过药物的皮肤,能够非常显著地提高药物透过皮肤的渗透作用。 Single-channel multi-frequency modulated ultrasound transducer emitting ultrasonic waves applied drug through the skin can be very significantly improved permeation of the drug through the skin.

[0010] 本发明公开了调制超声波中的高频(I~5MHz)分量、中频(20(T1000KHz)和低频(20-200ΚΗζ)分量超声波对经皮给药促渗透效应具有协同作用,调制超声波中的高频分量对经皮给药的促渗透主要作用是打开浅层皮肤(角质层和表皮)的给药传输通道,中频分量和低频分量的超声波促渗透主要作用是在高频分量超声波作用的基础上,进一步突破深层皮肤(真皮和皮下组织)的屏障,进行深度渗透。为医药行业提供了一种高效调制超声波促渗透经皮给药方法。 [0010] The present invention discloses a high-frequency modulation of the ultrasonic wave (I ~ 5MHz) component, the intermediate frequency (20 (T1000KHz) and low frequency (20-200ΚΗζ) components of the ultrasonic transdermal administration of a synergistic effect of the penetration, the ultrasonic modulation high-frequency component of the penetration-facilitating transdermal administration major role is to open the superficial skin (stratum corneum and epidermis) administration transmission channel, the intermediate frequency ultrasonic waves and low frequency components of the penetration is a major role in the high-frequency component of the ultrasonic waves on the basis of a further breakthrough barrier deep skin (dermis and subcutaneous tissue), the penetration depth providing transdermal administration ultrasonic modulation method for promoting an efficient permeation of the pharmaceutical industry.

[0011] 3.附图说明 [0011] 3. BRIEF DESCRIPTION

图1是本发明的调制超声波装置的结构框图; FIG. 1 is a block diagram of the modulation device of the present invention, the ultrasonic;

图2是本发明的调制超声波(脉冲波)的激励电信号图; FIG 2 is a modulator of the present invention, ultrasonic waves (pulse wave) of FIG stimulating electrical signal;

图3是本发明的调制超声波(连续波)的激励电信号图; FIG 3 is modulated ultrasonic waves (CW) of the present invention, FIG electrical excitation;

图4是本发明的调制超声波(混合波)的激励电信号图; FIG 4 is a modulator of the present invention, an ultrasonic (wave mixing) of FIG stimulating electrical signal;

图5是本发明的圆柱形单通道多频率超声波换能器的结构图; FIG 5 is a cylindrical single-channel configuration of the present invention is a multi-frequency diagram of an ultrasonic transducer;

图6是本发明的圆柱梯形单通道多频率超声波换能器的结构图; FIG 6 is a ladder of the present invention a cylindrical single-channel multi-frequency configuration diagram of an ultrasonic transducer;

图中主要部件符号说明: DESCRIPTION OF REFERENCE NUMERALS FIG main components:

1.参数设定单元 2.显示单元 The parameter setting unit 1. The display unit

3.开关电路控制单元 4.中央控制器 3. The switching circuit control unit 4. The central controller

5.高频分量单元 6.中频分量单元 The high-frequency component unit 6. The intermediate frequency component unit

7.低频分量单元 8.高频分量功率放大器 7. The low-frequency component unit 8. The high-frequency component of the power amplifier

9.中频分量功率放大器 10.低频分量功率放大器 9. The IF amplifier 10. The component of the low frequency component of the power amplifier

11.单通道多频率超声波换能器 11. The single-channel multi-frequency ultrasound transducer

12.调制器 13.功率放大控制单兀14.调制超声波高频分量的脉冲幅度与脉冲宽度 12. The modulator 13 power amplifier control unit 14. Wu modulated high-frequency component ultrasonic pulse amplitude and pulse width

15.调制超声波高频分量的脉冲频率 15. The ultrasonic wave pulse frequency modulation of the high frequency component

16.调制超声波高频分量与中频分量之间间歇时间 16. The time interval between the intermediate frequency component of the modulation frequency component of the ultrasonic

17.调制超声波中频分量的脉冲幅度与脉冲宽度 17. The ultrasonic pulse amplitude modulated intermediate frequency component of the pulse width

18.调制超声波中频分量的脉冲频率 18. The ultrasonic wave pulse frequency modulation component of the IF

19.调制超声波中频分量与低频分量之间间歇时间 19. The time interval between the intermediate frequency component of the modulated low-frequency component ultrasonic

20.调制超声波低频分量的脉冲幅度与脉冲宽度 20. The ultrasonic pulse amplitude modulation and pulse width of the low frequency component

21.调制超声波低频分量的脉冲频率 21. The ultrasonic wave pulse frequency modulated low frequency component

22.调制超声波低频分量与高频分量之间间歇时间 22. The time interval between the ultrasonic wave modulated high-frequency component and low frequency component

23.调制超声波高频分量的频率 23. The frequency modulated high-frequency component ultrasonic waves

24.调制超声波闻频分量的振幅 24. The amplitude of the modulation frequency component ultrasonic smell

25.调制超声波高频分量与中频分量之间间歇时间 25. The time interval between the intermediate frequency component of the modulation frequency component of the ultrasonic

26.调制超声波中频分量的频率 26. The ultrasound modulation frequency component of the IF

27.调制超声波中频分量的振幅 27. The ultrasonic wave amplitude modulation of an intermediate frequency component

28.调制超声波中频分量与低频分量之间间歇时间 28. The time interval between the ultrasonic modulated intermediate frequency component and the low frequency component

29.调制超声波低频分量的频率 29. The ultrasound modulation frequency is a low frequency component

30.调制超声波低频分量的振幅 30. The ultrasonic wave amplitude modulation of the low frequency component

31.调制超声波低频分量与高频分量之间间歇时间 31. The time interval between the ultrasonic wave modulated high-frequency component and low frequency component

32.调制超声波高频分量的脉冲幅度与脉冲宽度 32. The ultrasonic pulse amplitude modulation and pulse width of the high frequency component

33.调制超声波高频分量的脉冲频率 33. The ultrasonic wave pulse frequency modulation of the high frequency component

34.调制超声波高频分量与中频分量之间间歇时间 34. The time interval between the intermediate frequency component of the modulation frequency component of the ultrasonic

35.调制超声波中频分量的频率 35. The ultrasound modulation frequency component of the IF

36.调制超声波中频分量的振幅 36. The ultrasonic wave amplitude modulation of an intermediate frequency component

37.调制超声波中频分量与低频分量之间间歇时间 37. The time interval between the intermediate frequency component of the modulated low-frequency component ultrasonic

38.调制超声波低频分量的脉冲幅度与脉冲宽度 38. The ultrasonic pulse amplitude modulation and pulse width of the low frequency component

39.调制超声波低频分量的脉冲频率 39. The ultrasonic wave pulse frequency modulated low frequency component

40.调制超声波低频分量与高频分量之间间歇时间 40. The time interval between the ultrasonic wave modulated high-frequency component and low frequency component

41.谐振频率I压电陶瓷 42.谐振频率2压电陶瓷43.谐振频率3压电陶瓷44.填料 41. 42. The resonance frequency of the resonance frequency of the piezoelectric ceramic I 2 of piezoelectric ceramic 43. The resonance frequency of the piezoelectric ceramic 44. The filler 3

45.背衬吸收块 45. The absorbent backing block

46.谐振频率I压电陶瓷电极引线 46. ​​The resonance frequency of the piezoelectric ceramic electrode lead I

47.谐振频率2压电陶瓷电极引线 47. The resonance frequency of the piezoelectric ceramic electrode lead 2

48.谐振频率3压电陶瓷电极引线 48. The resonance frequency of the piezoelectric ceramic electrode lead 3

49.支架 50.谐振频率I压电陶瓷51.谐振频率2压电陶瓷52.谐振频率3压电陶瓷 49. 50. A holder 51. The resonance frequency of the resonance frequency of the piezoelectric ceramic I 2 of piezoelectric ceramic 52. The resonance frequency of the piezoelectric ceramic 3

53.腔体 53. cavities

54.谐振频率I压电陶瓷电极引线 54. The resonance frequency of the piezoelectric ceramic electrode lead I

55.谐振频率2压电陶瓷电极引线 55. The resonance frequency of the piezoelectric ceramic electrode lead 2

56.谐振频率3压电陶瓷电极引线57.填料 58.支架。 56. The resonance frequency of the piezoelectric ceramic electrode lead 57. 3 58. filler bracket.

[0012] [0012]

具体实施方式 detailed description

[0013] 下面结合附图和具体实施例对本发明调制超声波装置及其经皮给药的促渗透方法做进一步说明,附图中与现有技术相同的部件采用了相同的标号。 [0013] further described below in conjunction with the accompanying drawings and specific embodiments of the present invention is made of the modulation device and the ultrasonic penetration-percutaneous administration, the prior art with the accompanying drawings like parts are designated with the same reference numerals. 下述各实施例仅用于说明本发明而并非对本发明的限制。 Embodiments of the present invention the following examples are only for illustration and not limitation of the invention.

[0014] 1.调制超声波装置具体实施方式 [0014] 1. modulating the ultrasonic apparatus DETAILED DESCRIPTION

调制是各种通信系统的重要基础,广泛用于广播、电视、雷达、测量仪等电子设备。 Modulation is an important basis for various communication systems, are widely used in radio, television, radar, electronic devices such as the meter. 调制是一种将信号注入载波,以此信号对载波加以调制的技术,以便将原始信号转变成适合处理和传送的电波信号。 A modulation signal is injected into the carrier, in order to be a signal carrier modulation techniques, so as to convert the raw signal into a radio signal for processing and transmission. 所谓调幅调制是用调制信号控制载波的振荡振幅,使载波的振幅随着调制信号变化;调频调制是用调制信号控制载波的振荡频率,使载波的频率随着调制信号变化。 AM modulation is called an oscillation control carrier amplitude modulation signal, the amplitude modulation with the carrier signal changes; FM modulation signal with the oscillation frequency of the control carrier is modulated, the frequency modulated signal with the carrier wave changes. 这些不同的调制,是以不同的方法,将信号和载波合成的技术。 These different modulation methods are different, the carrier wave signal, and synthesis techniques.

[0015] 本发明的调制超声波装置既含有调频调制成分也包含调幅调制成分,是对三个频率不同和振幅不同电信号加以合成,生成具有一定的关联性调制超声波。 [0015] The modulation apparatus of the present invention the ultrasonic contains both FM modulation component also includes AM modulated component, a different electrical signal synthesizing three different frequencies and amplitudes, generating a modulated ultrasonic some relevance.

[0016] 图1是本发明的调制超声波装置的结构框图。 [0016] FIG. 1 is a block diagram of the modulated ultrasonic apparatus according to the present invention. 如图1所示,本发明的调制超声波装置包括产生调制超声波激励电信号的调制超声波发生器和发射调制超声波的超声波换能器,所述的超声波换能器为单通道多频率超声波换能器11。 , Modulating the ultrasonic apparatus 1 of the present invention comprises generating a modulated ultrasonic generator and an ultrasonic transmit modulation modulated ultrasonic excitation electrical signal of an ultrasonic transducer, the ultrasonic transducer is a single-channel multi-frequency ultrasound transducer 11.

[0017] 调制超声波发生器包括中央控制器4,与中央控制器4连接的开关电路控制单元 [0017] The ultrasonic generator comprises a modulating central controller 4, the control unit and the switching circuit 4 is connected to the central controller

3、参数设定单元1、显示单元2以及功率放大控制单元13,与开关电路控制单元3连接的调制器12,与开关电路控制单元3和中央控制器4连接的高频分量单元5、中频分量单元6以及低频分量单元7,还包括与功率放大控制单元13连接的高频分量功率放大器8、中频分量功率放大器9以及低频分量功率放大器10。 3, the parameter setting unit 1, display unit 2 and the power amplification control unit 13, a high-frequency component unit modulator circuit connected to the switching control unit 312, a switch circuit connected to the control unit 3 and the central controller 45, an intermediate frequency components of low-frequency component unit 6 and unit 7, and further comprising a power amplification control unit 13 is connected to amplifier high frequency components 8, 9 and the intermediate frequency component of the low frequency component of the power amplifier 10 a power amplifier. 高频分量单元5与高频分量功率放大器8连接,中频分量单元6与中频分量功率放大器9连接,低频分量单元7与低频分量功率放大器10连接。 High-frequency component unit 58 is connected to the high-frequency component of the power amplifier, the intermediate frequency component unit 6 is connected to the intermediate frequency component of the power amplifier 9, low-frequency component unit 7 is connected to the low-frequency component of the power amplifier 10. 调制器12又分别与高频分量功率放大器8、中频分量功率放大器9和低频分量功率放大器10连接。 Modulator 12 and 8, the intermediate frequency component and low frequency component of the power amplifier 9 is connected to the high-frequency component of the power amplifier 10 a power amplifier, respectively.

[0018] 其中,高频分量单元5、中频分量单元6以及低频分量单元7内部分别设置有连续波发生器和脉冲波发生器,可以产生频率和幅度不同的脉冲波、连续波。 [0018] wherein the high-frequency component unit 5, an intermediate frequency component of the low-frequency component unit 6 and unit 7 are provided inside the continuous wave generator and the pulse generator, may generate a different amplitude and frequency pulse continuous wave.

[0019] 调制器按照参数设定的要求,输出调制超声波(脉冲波)的激励电信号,如图2 ;或输出调制超声波(连续波)的激励波电信号,如图3 ;或输出调制超声波(混合波)的激励波电信号,如图4。 [0019] The modulator according to the requirements set parameters, and outputs modulation ultrasonic waves (pulse) electrical excitation, as shown in FIG 2; or an ultrasonic output of the modulator; excitation wave electrical or ultrasonic modulation output (continuous wave), and FIG. 3 (mixed wave) excited wave electrical signal, as shown in FIG 4.

[0020] 单通道多频率超声波换能器系指共用同一腔体副射多个不同频率的超声波,副射方向和路径相同。 [0020] Single-channel multi-frequency ultrasonic transducer means common ultrasound frequencies of a plurality of different sub emitted same cavity, and the emission direction of the same sub-path. 单通道多频率超声波换能器11可以采用圆柱形单通道多频率超声波换能器,或者圆柱梯形单通道多频率超声波换能器。 Single-channel multi-frequency ultrasonic transducer 11 may employ a cylindrical single-channel multi-frequency ultrasonic transducer, trapezoidal or cylindrical single-channel multi-frequency ultrasonic transducer.

[0021] 图5是本发明的圆柱形单通道多频率超声波换能器的结构图。 [0021] FIG. 5 is a cylindrical single-channel multi-frequency structure of the present invention an ultrasonic transducer of FIG. 如图5所示,圆柱形单通道多频率超声波换能器包括外部的支架49,填充在支架49内部的填料44和背衬吸收块45。 As shown in FIG. 5, the cylindrical single-channel multi-frequency ultrasound transducer includes an outer bracket 49, inner bracket 49 is filled in the filler 44 and the backing block 45 absorption. 背衬吸收块45位于左半部分,填料44位于右半部分。 The backing block 45 is located in the left part of the absorbent, a filler 44 is located in the right half. 超声波换能器内部设置有分别对应于三个不同频率的谐振频率I压电陶瓷41、谐振频率2压电陶瓷42和谐振频率3压电陶瓷43。 The ultrasonic transducer is provided inside with a resonance frequency corresponding to the three different frequencies of the piezoelectric ceramic I 41, the resonance frequency of the piezoelectric ceramic 42, and the resonance frequency of the piezoelectric ceramic 43 3. 谐振频率I压电陶瓷41两侧设置有谐振频率I压电陶瓷电极引线46,谐振频率2压电陶瓷42两侧设置有谐振频率2压电陶瓷电极引线47,谐振频率3压电陶瓷43两侧设置有谐振频率3压电陶瓷电极引线48。 I resonant frequency of the piezoelectric ceramic 41 are provided on both sides of the resonance frequency of the piezoelectric ceramic I electrode lead 46, the resonant frequency of the piezoelectric ceramic 42 are provided on both sides of the resonance frequency of the piezoelectric ceramic 2 electrode lead 47, the resonance frequency of the piezoelectric ceramic 43 two 3 3 side is provided with a resonant frequency of the piezoelectric ceramic electrode lead 48. 三个圆形压电陶瓷平行分布于填料中,分别通过各自的压电陶瓷电极弓丨线与调制器和开关电路控制单元连接。 Three circular piezoelectric ceramic filler distributed in parallel, are connected via respective piezoelectric ceramic electrode wire bow Shu modulator and a switching circuit control unit.

[0022] 图6是本发明的圆柱梯形单通道多频率超声波换能器的结构图。 [0022] FIG. 6 is a cylindrical trapezoid single channel multi-frequency structure of the present invention an ultrasonic transducer of FIG. 如图6所示,圆柱梯形单通道多频率超声波换能器包括外部的支架58和内部的填料57,填料57中央的腔体53 —端形成梯形。 6, a cylindrical trapezoid single channel multi-frequency ultrasonic transducer includes a bracket 58 outside and inside the fillers 57, the filler 53 of the central cavity 57 - terminal trapezoidal. 超声波换能器内部设置有分别对应于三个不同频率的谐振频率I压电陶瓷50、谐振频率2压电陶瓷51和谐振频率3压电陶瓷52。 The ultrasonic transducer is provided inside with a resonance frequency corresponding to the three different frequencies of the piezoelectric ceramic I 50, the resonance frequency of the piezoelectric ceramic 51 and the resonance frequency of the piezoelectric ceramic 52 3. 谐振频率I压电陶瓷50两侧设置有谐振频率I压电陶瓷电极引线54,谐振频率2压电陶瓷51两侧设置有谐振频率2压电陶瓷电极引线55,谐振频率3压电陶瓷52两侧设置有谐振频率3压电陶瓷电极引线 I resonant frequency of the piezoelectric ceramic 50 are provided on both sides of the resonance frequency of the piezoelectric ceramic I electrode lead 54, the resonant frequency of the piezoelectric ceramic 51 are provided on both sides of the resonance frequency of piezoelectric ceramic electrode lead 55, the resonance frequency of the piezoelectric ceramic 52 two 3 side with a resonant frequency of the piezoelectric ceramic electrode lead 3

56。 56. 三个圆环状压电陶瓷分布于腔体一端的梯形阶梯上,分别通过各自的压电陶瓷电极引线与调制器和开关电路控制单元连接。 Three annular piezoceramic distributed on one end of the stepped trapezoidal cavities, are connected by a respective piezoelectric ceramic electrode lead modulator and a switching circuit control unit. 压电陶瓷用于将调制电信号转化为调制超声波,并向外发射。 Piezoelectric ceramics for modulating the modulated electrical signal into ultrasonic waves, and emitted outward.

[0023] 本发明的调制超声波装置的工作过程如下: [0023] The processes and apparatus of the present invention, an ultrasonic modulator is as follows:

中央控制器根据设定的参数同时向开关电路控制单元、功率放大控制单元和高频分量单元、中频分量单元、低频分量单元发出指令,高频分量单元、中频分量单元和低频分量单元按照指令要求生产连续波或脉冲波高频分量、中频分量和低频分量电信号,这三个分量电信号分别由高频分量功率放大器、中频分量功率放大器和低频分量功率放大器加以适当的放大,放大倍数服从功率放大控制单元的指令要求,调制器将放大后的高频分量、中频分量和低频分量电信号按照参数设定要求进行合成,完成调制。 At the same time the central controller to the switching circuit control unit, the power amplifier according to the parameters set by the control unit and a high-frequency component unit, the intermediate frequency component unit, an instruction unit issues the low frequency component, high-frequency component unit, the intermediate frequency component and low-frequency component unit cell in accordance with Directive producing a continuous wave or a pulse wave frequency component, the intermediate frequency electrical signal and low frequency components, respectively three components of an electrical signal amplifier to be a high-frequency component, the intermediate frequency component and low frequency components of the power amplifier PA appropriate amplification, subject to power magnification amplification control instruction unit request, the high-frequency component amplified modulator, intermediate and low frequency components are synthesized according to the parameters set electrical requirements, the modulating is done. 开关电路控制单元按照中央控制器的指令要求对高频分量单元、中频分量单元和低频分量单元是生产连续波还是脉冲波电信号进行切换,还负责单通道多频率超声波换能器的工作频率与调制器输出的调制高频分量、中频分量和低频分量电信号的步调一致的切换。 Switching circuit control means in accordance with instructions from the central control unit of the requirements of high-frequency component, the intermediate frequency component and low-frequency component unit is a unit for producing a continuous wave or pulsed wave electrical switch also responsible for a single channel multi-frequency ultrasonic transducer operating frequency modulated high frequency component of the modulated output, in step, the intermediate frequency and low frequency components of the electrical switch. 最后,通过单通道多频率超声波换能器把调制电信号转化成调制超声波。 Finally, by single-channel multi-frequency modulated ultrasonic transducer converts electrical signals into a modulated ultrasound.

[0024] 2.调制超声波对经皮给药的促渗透方法具体实施方式: [0024] 2. The method of modulating the penetration of ultrasound on the percutaneous administration DETAILED DESCRIPTION:

调制超声波发生器的输出终端需用电缆与单通道多频率超声波换能器连接,使用单通道多频率超声波换能器照射涂过药物的皮肤。 Modulation output terminal cable required sonotrode single channel multi-frequency ultrasonic transducer is connected, a single-channel multi-frequency ultrasonic transducer irradiating the coated drug skin.

[0025] 实施例1 [0025] Example 1

生物活体经皮给药试验:选用约200克昆明种雄性大鼠一只,剃除约4cm2皮肤表面的体毛,表皮处理干净后,涂抹药物2%盐酸利多卡因胶浆(具体配方:盐酸利多卡因10g,壳聚糖4 g, 二甲硅油10 ml,轻苯乙脂0.2 g,5ml聚山梨脂80,加蒸懼水至500ml) 2克。 Biological vivo percutaneous administration of the test: about 200 Ke Kunming species selected a male rats, body hair shaved skin surface about 4cm2, a clean epidermis treated, the drug applied lidocaine hydrochloride mucilage 2% (specific formulations: Lee hydrochloride Cain 10g, chitosan 4 g, simethicone 10 ml, light aliphatic phenylethyl 0.2 g, 5ml polysorbate 80, was added to distilled water fear 500ml) 2 grams. 根据实际需求,设置调制超声波的所有参数,高频分量1000kHz、强度0.20W/cm2、脉冲序列占空比10%,中频分量220 kHz、强度0.18W/cm2、脉冲序列占空比16%,低频分量20 kHz、强度 According to actual demand, all the parameters set modulated ultrasonic, high-frequency components 1000kHz, intensity 0.20W / cm2, 10% duty cycle pulse train, the intermediate frequency component of 220 kHz, intensity 0.18W / cm2, 16% duty cycle pulse train, the low-frequency component of 20 kHz, intensity

0.14 W/cm2、脉冲序列占空比18%,闻频分量与中频分量间歇为5 us,中频分量与低频分量间歇为15us,低频分量与高频分量间歇为50us,调制超声波的高频分量、中频分量和低频分量各自的持续时间分别为20 us,45 us、150 us。 0.14 W / cm2, 18% duty cycle pulse train, the intermediate frequency component and the frequency component of the smell is intermittently 5 us, the intermediate frequency component and the low frequency component is 15us intermittently, the intermittent high-frequency component and low frequency component to high frequency component 50us, modulated ultrasonic waves, the duration of each intermediate frequency and low frequency components are 20 us, 45 us, 150 us. 用单通道多频率超声波换能器照射涂过药物2%盐酸利多卡因胶浆的皮肤,换能器幅射直径为20mm。 A single-channel multi-frequency ultrasonic transducer irradiating the coated pharmaceutical mucilage 2% lidocaine skin, the diameter of the radiation transducer to 20mm. 第60分钟抽取老鼠的血液 Blood was drawn 60 minutes mice

1.5ml,立刻加1.5ml枸櫞酸,离心分离后取上清液20ul,进行液相色谱分析。 1.5ml, 1.5ml and immediately add citrate, 20ul supernatant after centrifugation, analyzed by liquid chromatography. 色谱条件为:C18柱、4.6X250mm、5um,以醋酸溶液(取冰醋酸50ml,加蒸懼水930ml,用lmol/L氢氧化钠溶液调节PH值至3.40)—甲醇(40:60 )为流动相,检测波长254nm,柱温30°C。 Chromatographic conditions: C18 column, 4.6X250mm, 5um, a solution of acetic acid (acetic acid taken 50ml, fear add distilled water 930ml, adjusting the PH value lmol / L aqueous sodium hydroxide solution to 3.40) - methanol (40:60) as mobile detection wavelength 254nm, column temperature 30 ° C. 测得盐酸利多卡因血药浓度为19.7ug/ml。 Lidocaine hydrochloride plasma concentration obtained was measured 19.7ug / ml. 用同样的方法,同样的实验参数,分别用高频分量对应的超声波1000kHz、强度0.20W/cm2、脉冲序列占空比10%,中频分量对应的超声波220 kHz、强度 The same way, the same experimental parameters, respectively corresponding to the high-frequency component ultrasonic waves 1000kHz, intensity 0.20W / cm2, 10% duty cycle pulse train, the intermediate frequency component corresponding ultrasonic 220 kHz, intensity

0.18 W/cm2、脉冲序列占空比16%,和低频分量对应的超声波20 kHz、强度0.14 W/cm2、脉冲序列占空比18%,使用对应频率超声波换能器(幅射直径为20mm)照射涂过2克药物2%盐酸利多卡因胶浆的皮肤。 0.18 W / cm2, 16% duty cycle pulse train, and a low frequency component corresponding to the ultrasound 20 kHz, intensity of 0.14 W / cm2, 18% duty cycle pulse sequence, using the corresponding frequency of the ultrasonic transducer (radiation diameter 20mm) irradiating the coated pharmaceutical 2 g of 2% lidocaine hydrochloride mucilage skin. 在第20分钟抽取老鼠的血液1.5ml,经处理后,测得盐酸利多卡因血药浓度分别为3.lug/ml、3.7ug/ml、3.8ug/ml。 Extracting the first 20 minutes of blood 1.5ml mice, after treatment, the measured plasma concentration of lidocaine hydrochloride were 3.lug / ml, 3.7ug / ml, 3.8ug / ml. 实验结果是,使用调制超声波方法测得盐酸利多卡因血药浓度大于高频分量、中频分量和低频分量对应的超声波方法3次测得盐酸利多卡因血药浓度的加和。 The experimental results, the use of ultrasonic waves measured as the modulation of lidocaine hydrochloride plasma concentration is greater than the high frequency component, the intermediate frequency of ultrasonic waves and low frequency components corresponding to the three measured plasma concentrations of lidocaine hydrochloride and added.

[0026] 使用与调制超声波相同参数的高频分量对应的超声波照射20分钟后,切换用中频分量对应的超声波照射20分钟后,切换用低频分量对应的超声波照射20分钟,分别使用对应频率超声波换能器(换能器幅射直径为20mm)照射涂过2克药物2%盐酸利多卡因胶浆的老鼠的皮肤。 [0026] The ultrasonic irradiation, high-frequency components using the same modulation parameters corresponding to ultrasound for 20 minutes, ultrasonic irradiation switching component corresponding to the intermediate frequency after 20 minutes, ultrasonic irradiation switching frequency component corresponding to 20 minutes, respectively, using the corresponding frequency ultrasonic transducer transducer (radiation transducer diameter for 20mm) irradiating the coated pharmaceutical 2% hydrochloric acid 2 g of rat skin lidocaine mortar. 第60分钟(三段超声波照射的合计时间为60分钟)抽取老鼠的血液1.5ml,经处理后,测得盐酸利多卡血药浓度为11.8ug/ml。 60 minutes (three-stage ultrasonic irradiation time was 60 minutes total) 1.5ml blood drawn mice, after treatment, the measured plasma concentration of hydrochloric acid lidocaine 11.8ug / ml. 实验结果是,使用调制超声波方法测得盐酸利多卡因血药浓度大于高频分量、中频分量和低频分量对应的超声波三段照射测得盐酸利多卡因血药浓度的总和。 The experimental results, the use of ultrasonic waves measured as the modulation of lidocaine hydrochloride plasma concentration is greater than the high frequency components, intermediate and low frequency components corresponding to the three sections irradiated with ultrasonic waves to obtain the sum of the measured plasma concentration of lidocaine hydrochloride.

[0027] 本底实验:没有超声波照射,用同样的方法检测,在第60分钟测得药物盐酸利多卡因血药浓度是9.8ug/ml。 [0027] Background experiment: ultrasonic irradiation is not detected by the same method, the first 60 minutes, measured lidocaine hydrochloride drug plasma concentration was 9.8ug / ml.

[0028] 实验证明,调制超声波中的高频分量、中频分量和低频分量对经皮给药的促渗透效应具有协同作用。 [0028] The experiments show that the high frequency components of the modulated ultrasonic waves, the intermediate frequency and low frequency components have a synergistic effect on the penetration transdermal administration.

[0029] 完成以上实验所用的大鼠为同一只,每次实验时间相隔叁天。 [0029] After the above experiments was the same as rats only, each time separated by Santian experiment.

[0030] 实施例2` [0030] Example 2 '

离体经皮给药试验:离体鼠皮的制备,取约200克昆明种雄性大鼠一只,处死后剃除鼠毛,确保皮肤角质层完好无损,除去皮下组织和脂肪,用生理盐水漂洗干净。 Percutaneous administration of the test body from: Preparation of mouse skin from the body, taking about 200 Ke Kunming species of a male rats, mice were sacrificed after shave hair, to ensure intact stratum corneum, and subcutaneous fat removed with saline rinse. 取适当面积漂洗干净的离体鼠皮,角质层面朝向供给池,固定于Franz扩散池(Franz扩散池由供给池和接收池两部分组成)中间。 Take appropriate area rinse vitro rat skin, the stratum corneum side facing the supply tank, is fixed to a Franz diffusion cell (Franz cell consists of two supply tank and the receiving tank section) intermediate. Franz扩散池直径22mm,其中供给池容积30ml,接收池容积60ml,接收池注满25%乙醇一生理盐水,确保与鼠皮之间无气泡,接收池内需放入一枚磁力搅拌子,在供给池内加入药物5%咖啡因(配制方法:取5g咖啡因、25ml乙醇、IOml丙二醇,加 Franz diffusion cell diameter of 22mm, wherein the supply tank volume 30ml, receiving pool volume 60ml, holding tank filled with a 25% ethanol physiological saline, to ensure that no air bubbles, into a receiving pool required magnetic force between the murine skin stirrer, supplied Drug was added 5% caffeine pool (preparation method: 5g of caffeine, 25ml ethanol, IOml propylene glycol, add

0.1M醋酸钠缓冲溶液(PH=7.1)至100ml,搅拌至咖啡因完全溶解后,再加Ig卡波940,搅匀)2g。 0.1M sodium acetate buffer solution (PH = 7.1) to 100ml, stirred until complete dissolution of caffeine, plus the Ig Carbopol 940, mix) 2g. Franz扩散池需保持32°C恒温,将Franz扩散池放在磁力搅拌器上,搅拌速度200转/分钟。 Franz diffusion cells required to maintain constant temperature 32 ° C, the Franz cell on a magnetic stirrer, a stirring speed of 200 rev / min. 把单通道多频率超声波换能器插入供给池,换能器幅射直径为20_,设置调制超声波的所有参数,高频分量3000kHz连续波、强度0.40ff/cm2,中频分量为无,低频分量20kHz连续波、强度0.30 W/cm2,高频分量与低频分量之间无间歇,调制超声波的高频分量和低频分量各自的持续时间相同,均为300 us,开启调制超声波发生器。 The single-channel multi-frequency ultrasonic transducer inserted into the feeder tank, the transducer diameter 20_ radiation, ultrasonic modulation set all the parameters, the high frequency component 3000kHz continuous wave, the intensity of 0.40ff / cm2, no component of the intermediate frequency, a low frequency component 20kHz continuous wave, the intensity of 0.30 W / cm2, no high-frequency component and low frequency component between the intermittent, high-frequency and low frequency components of the modulated ultrasound same duration each, are 300 us, modulated ultrasonic generator is turned on. 分别在第15、30、45、60分钟,吸取5ml接收液,同时回补等量的25%乙醇一生理盐水。 At its 15,30,45,60 minutes, 5ml receiving liquid draw, while covering the same amount of a 25% ethanol physiological saline. 吸取的接收液经离心分离过滤处理后,使用紫外分光光度法检测其药物咖啡因浓度,检测波长273nm。 After receiving pipetted filtering by centrifuging, using ultraviolet spectrophotometry pharmaceutical caffeine concentration, detection wavelength 273nm. 测得药物咖啡因浓度分别为17.6ug/ml、17.2ug/ml、16.7ug/ml、16.7ug/ml。 Drug concentration was found to have caffeine 17.6ug / ml, 17.2ug / ml, 16.7ug / ml, 16.7ug / ml, respectively.

[0031] 用同样的方法,同样的实验参数,使用高频分量对应的超声波3000kHz连续波、强度0.40W/cm2,和对应频率3000kHz超声波换能器,分别在第15、30、45、60分钟,吸取5ml接收液,同时回补等量的25%乙醇一生理盐水。 [0031] the same way, the same experimental parameters, using an ultrasonic continuous wave high-frequency component corresponding to 3000kHz, the intensity 0.40W / cm2, and the corresponding frequency 3000kHz ultrasonic transducers, respectively, in the first minute 15,30,45,60 , 5ml receiving liquid suction, while covering the same amount of a 25% ethanol physiological saline. 吸取的接收液经离心分离过滤处理后,使用紫外分光光度法测得药物咖啡因浓度分别是3.3ug/ml、7.2ug/ml、7.3ug/ml、7.4ug/ml ;使用低频分量对应的超声波20kHz连续波、强度0.40 W/cm2,和对应频率20 kHz超声波换能器,分别在第15、30、45、60分钟,测得药物咖啡因浓度分别是4.8ug/ml、9.0ug/ml、8.8ug/ml、8.6ug/ml。 After receiving pipetted centrifuged filtering process, using the drug as measured by UV spectrophotometry caffeine concentration was 3.3ug / ml, 7.2ug / ml, 7.3ug / ml, 7.4ug / ml; low frequency components corresponding to an ultrasonic 20kHz continuous wave, the intensity of 0.40 W / cm2, and the corresponding frequency of 20 kHz ultrasonic transducers, respectively, in the first 15,30,45,60 minutes to obtain the drug concentration of caffeine were measured 4.8ug / ml, 9.0ug / ml, 8.8ug / ml, 8.6ug / ml.

[0032] 实验结果也是,使用调制超声波方法测得接收液的药物咖啡因浓度大于高频分量3000kHz和低频分量20kHz对应的超声波方法测得接收液的药物咖啡因浓度。 [0032] The results are drug concentration of caffeine was measured using a modulation method of the received ultrasonic waves is greater than the high frequency components of the drug solution concentration of caffeine was measured received ultrasonic methods 3000kHz and 20kHz frequency component corresponding.

[0033] 本底实验:没有超声波照射,用同样的方法检测,在第15、30、45、60分钟测得接收液的药物咖啡因浓度分别是3.2ug/ml、4.9ug/ml、5.4ug/ml、5.5ug/ml。 [0033] Background experiment: no ultrasonic irradiation, detected by the same method, the drug concentration of caffeine in the first minute was measured receiving liquid 15,30,45,60 respectively 3.2ug / ml, 4.9ug / ml, 5.4ug /ml,5.5ug/ml.

[0034] 实验证明,调制超声波对经皮给药的促渗透效应具有协同作用。 [0034] The experiments show a synergistic effect of the ultrasonic modulated osmotic effect promoting transdermal administration.

Claims (9)

1.一种调制超声波装置,其特征在于:该调制超声波装置包括产生调制超声波激励电信号的调制超声波发生器和发射调制超声波的单通道多频率超声波换能器。 An ultrasonic modulating means, characterized in that: the modulating means comprises an ultrasonic generator and an ultrasonic generating a modulation emitting modulated single-channel ultrasonic modulator ultrasonic excitation electrical signal of multi-frequency ultrasonic transducer.
2.根据权利要求1所述的调制超声波装置,其特征在于:所述的调制超声波发生器包括中央控制器,与中央控制器连接的开关电路控制单元、参数设定单元、显示单元以及功率放大控制单元,与开关电路控制单元连接的调制器,与开关电路控制单元和中央控制器连接的高频分量单元、中频分量单元以及低频分量单元,还包括与功率放大控制单元连接的高频分量功率放大器、中频分量功率放大器以及低频分量功率放大器;高频分量单元与高频分量功率放大器连接,中频分量单元与中频分量功率放大器连接,低频分量单元与低频分量功率放大器连接,调制器又分别与高频分量功率放大器、中频分量功率放大器和低频分量功率放大器连接;高频分量单元、中频分量单元以及低频分量单元内部分别设置有连续波发生器和脉冲波发生器。 The ultrasonic modulating apparatus according to claim 1, wherein: said modulation circuit for controlling the ultrasonic generator comprises a switching unit central controller, the central controller is connected, the parameter setting unit, a display unit and power amplifier the control unit, the modulator control unit connected to the switching circuit, high-frequency component unit connected to the switching circuit of the control unit and the central controller, and the intermediate frequency component of the low-frequency component unit means further includes a high frequency component power amplification control unit and connected to a power amplifier, the intermediate frequency component and low frequency component of the power amplifier PA; high-frequency component and the high-frequency component of the power amplifier unit is connected to the intermediate frequency component and the intermediate frequency component of the power amplifier unit is connected to the low-frequency component of the power amplifier unit connected to the low-frequency component, respectively, high and modulators frequency component of the power amplifier, the power amplifier and the low frequency components of the intermediate frequency amplifier connected components; high-frequency component unit, the intermediate frequency component of low-frequency component unit and an internal unit are respectively provided with a continuous wave generator and a pulse wave generator.
3.根据权利要求2所述的调制超声波装置,其特征在于:调制超声波发生器产生调制超声波激励电信号既含有调频调制成分也包含调幅调制成分,是对三个频率不同和振幅不同的脉冲波、或连续波或脉冲波与连续波组合成的混合波电信号加以合成,生成具有关联性调制超声波激励电信号。 3. modulation of the ultrasonic device according to claim 2, wherein: the modulated ultrasonic generator generates ultrasonic excitation electrical signal containing both modulation FM modulation component also includes AM modulated component is three different frequencies and different amplitudes of the pulse wave , or a continuous wave or pulsed wave and continuous wave mixing waves combined into an electric signal to be synthesized, to generate an associated modulation ultrasonic excitation electrical signal.
4.根据权利要求3所述的调制超声波装置,其特征在于:调制超声波发生器所产生的激励电信号有脉冲波、或连续波或脉冲波与连续波组合成的混合波多种波形激励电信号;激励电信号的频率和幅度(或脉冲幅度与脉冲宽度)可以调节;激励电信号的高频分量频率范围为I~5MHz,中频分量频率范围为200~1000KHz,低频分量频率范围为20~200KHz ;脉冲波的占空比范围为1%~99% ;调制超声波激励电信号周期为调制超声波包含的高频分量、中频分量和低频分量各自的持续时间与三个分量相互之间时间间歇的加和,三个分量各自的持续时间范围为调制超声波周期2~98%。 Modulating an ultrasonic apparatus according to claim claim 3, wherein: the excitation electrical signal generated by the modulation generator has an ultrasonic pulse or continuous wave or pulsed wave and continuous wave mixing waves are combined into a plurality of electrical excitation waveform ; excitation frequency and amplitude of the electrical signal (or pulse amplitude and pulse width) can be adjusted; high-frequency component of the electrical excitation frequency range of I ~ 5MHz, the frequency range of the intermediate frequency component of 200 ~ 1000KHz, low frequency components in the frequency range 20 ~ 200KHz ; pulse duty cycle range of 1% to 99%; modulated ultrasonic excitation electrical cycles of high-frequency component contained in the modulated ultrasonic wave, plus the time interval between each of the respective intermediate duration and low frequency components of the three components and, each of the three components of the ultrasonic duration modulation period ranging from 2 to 98%.
5.根据权利要求1所述的调制超声波装置,其特征在于:所述的单通道多频率超声波换能器包括圆柱形和圆柱梯形单通道多频率超声波换能器,其中,圆柱形单通道多频率超声波换能器,包括外部的支架`和内部的填料,三个圆形压电陶瓷平行分布于填料中,分别通过各自的压电陶瓷电极引线与调制器和开关电路控制单元连接;圆柱梯形单通道多频率超声波换能器,包括外部的支架和内部的填料,填料中央的腔体一端形成梯形,三个圆环状压电陶瓷分布于腔体一端的梯形阶梯上,分别通过各自的压电陶瓷电极引线与调制器和开关电路控制单元连接;单通道多频率超声波换能器把调制超声波激励电信号转换调制超声波。 The modulated ultrasonic wave device according to claim 1, wherein: said single-channel multi-frequency ultrasonic transducer comprises a cylindrical cylinder and a trapezoidal single-channel multi-frequency ultrasonic transducer, wherein the multiple single channel cylindrical frequency ultrasonic transducer, comprising a filler external and internal brackets', three circular piezoelectric ceramic filler distributed in parallel, independently from each electrode lead piezoelectric ceramic modulator and a switching circuit connected by a control unit; trapezoidal cylinder single-channel multi-frequency ultrasonic transducer, including a filler inside and outside the stent, one end of the cavity forming a trapezoidal central filler, three annular piezoceramic distributed on one end of the stepped trapezoidal cavity, through their respective pressure ceramics electrode lead modulator and a switching circuit connected to a control unit; single-channel multi-frequency modulated ultrasound transducer converts an electrical signal modulated ultrasonic ultrasonic excitation.
6.根据权利要求5所述的调制超声波装置,其特征在于:单通道多频率超声波换能器内三个压电陶瓷各自谐振频率取值分别处在高频分量(I~5MHz)、中频分量(200~ΙΟΟΟΚΗζ)、低频分量(20~200KHz)的频率范围内,具体取值取决于所用药物,药物不同,取值不同;所发射调制超声波强度范围为0.05~lOW/cm2 ;单通道系指调制超声波幅射方向和路径相同。 6. The modulation of the ultrasonic apparatus according to claim 5, wherein: the single-channel multi-frequency three piezoceramic ultrasonic transducer within the transducer resonant frequency of each value in each high-frequency component (I ~ 5MHz), an intermediate frequency component inner (200 ~ ΙΟΟΟΚΗζ), low-frequency component (20 ~ 200KHz) frequency range, depending on the specific value of the drug, different drugs, different values; modulating the transmitted intensity of ultrasonic waves in the range of 0.05 ~ lOW / cm2; single channel means ultrasonic horn and the same modulation path direction.
7.权利要求1所述调制超声波装置所产生的调制超声波在经皮给药方面的应用。 Ultrasonic modulation means modulating the generated ultrasound application 1 in the percutaneous administration as claimed in claim 7.
8.根据权利要求7所述的应用,其特征在于:调制超声波参数设定,包括激励电信号波形,是脉冲波、还是连续波或者是脉冲波与连续波组合成的混合波,高频分量(I~5MHz)、中频分量(200~ΙΟΟΟΚΗζ)、低频分量(20~200ΚΗζ)三个分量的频率具体取值,三个分量的振幅或脉冲幅度和脉冲波占空比取值,调制超声波三个分量的强度取值(强度范围`0.05~10 ff/cm2),闻频分量、中频分量、低频分量三个分量相互之间的时间间歇取值(时间间歇范围为高频分量周期时间的I倍至低频分量周期时间的1000倍);调制超声波的高频分量、中频分量和低频分量各自的持续时间,三个分量各自的持续时间范围为调制超声波周期2~98%,调制超声波幅射时间取值(幅射时间范围0.5分钟至24小时)。 8. The use according to claim 7, wherein: the modulated ultrasonic parameter settings, including electrical excitation waveform, a pulse wave or continuous wave or pulsed wave and continuous wave combined into a hybrid wave, high frequency components (I ~ 5MHz), the intermediate frequency components (200 ~ ΙΟΟΟΚΗζ), low-frequency component (20 ~ 200ΚΗζ) three component values ​​of the specific frequency, amplitude or pulse width and three component values ​​of the duty cycle of the pulse wave, the ultrasonic three modulation component values ​​intensities (intensity range `0.05 ~ 10 ff / cm2), Wen-frequency component, the intermediate frequency component, a low frequency component of the three components to each other between the time interval value (time interval in the range of high-frequency components of the time period I fold to 1000-fold the low frequency components of the cycle time); respective durations of the ultrasonic wave modulated high-frequency component, the intermediate frequency and low frequency components, the three components of each of the ultrasonic duration modulation period ranging from 2 to 98%, the ultrasonic horn modulation time value (radiation time ranges from 0.5 to 24 minutes).
9.根据权利要求7所述的应用,其特征在于:调制超声波的高频分量(I~5MHz)、中频分量(200~ΙΟΟΟΚΗ`ζ)、低频分量(20~200KHz)对经皮给药促渗透效应产生协同作用。 9. Use according to claim 7, wherein: the high-frequency component of the modulated ultrasound (I ~ 5MHz), the intermediate frequency components (200 ~ ΙΟΟΟΚΗ`ζ), low-frequency component (20 ~ 200KHz) percutaneous administration on the growth of osmotic effect synergistic effect.
CN 201410112423 2014-03-25 2014-03-25 An ultrasonic apparatus and method for percutaneous administration of the penetration-modulation CN103861204B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 201410112423 CN103861204B (en) 2014-03-25 2014-03-25 An ultrasonic apparatus and method for percutaneous administration of the penetration-modulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 201410112423 CN103861204B (en) 2014-03-25 2014-03-25 An ultrasonic apparatus and method for percutaneous administration of the penetration-modulation

Publications (2)

Publication Number Publication Date
CN103861204A true true CN103861204A (en) 2014-06-18
CN103861204B CN103861204B (en) 2016-06-22

Family

ID=50900581

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 201410112423 CN103861204B (en) 2014-03-25 2014-03-25 An ultrasonic apparatus and method for percutaneous administration of the penetration-modulation

Country Status (1)

Country Link
CN (1) CN103861204B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569099B1 (en) * 2001-01-12 2003-05-27 Eilaz Babaev Ultrasonic method and device for wound treatment
CN101172086A (en) * 2007-11-27 2008-05-07 王建友 Ultrasonic acupuncture instrument
CN201375764Y (en) * 2009-04-23 2010-01-06 王建友 Ultrasonic treatment apparatus
CN101670143A (en) * 2008-09-11 2010-03-17 姚广权;姚广智 Medical infusion device
CN202892654U (en) * 2012-10-30 2013-04-24 沈阳中康世创科技有限公司 Percutaneous drug-leading in instrument signal generating circuit

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569099B1 (en) * 2001-01-12 2003-05-27 Eilaz Babaev Ultrasonic method and device for wound treatment
CN101172086A (en) * 2007-11-27 2008-05-07 王建友 Ultrasonic acupuncture instrument
CN101670143A (en) * 2008-09-11 2010-03-17 姚广权;姚广智 Medical infusion device
CN201375764Y (en) * 2009-04-23 2010-01-06 王建友 Ultrasonic treatment apparatus
CN202892654U (en) * 2012-10-30 2013-04-24 沈阳中康世创科技有限公司 Percutaneous drug-leading in instrument signal generating circuit

Also Published As

Publication number Publication date Type
CN103861204B (en) 2016-06-22 grant

Similar Documents

Publication Publication Date Title
US6527716B1 (en) Microporation of tissue for delivery of bioactive agents
US6273864B1 (en) Ultrasonic treatment for wounds
US20030040698A1 (en) Ultrasonic surgical instrument for intracorporeal sonodynamic therapy
US20050165393A1 (en) Microporation of tissue for delivery of bioactive agents
Fang et al. Enhancement of topical 5‐aminolaevulinic acid delivery by erbium: YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation
US5582586A (en) Drug administration and humor sampling unit and an apparatus therefor
US20040186384A1 (en) Ultrasonic method and device for wound treatment
Azagury et al. Ultrasound mediated transdermal drug delivery
Mason Therapeutic ultrasound an overview
US5267985A (en) Drug delivery by multiple frequency phonophoresis
Mitragotri Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers
Schuetz et al. Emerging strategies for the transdermal delivery of peptide and protein drugs
US6689380B1 (en) Remote and local controlled delivery of pharmaceutical compounds using electromagnetic energy
US20070299369A1 (en) Ultrasound wound care device and method
Rao et al. Sonophoresis: recent advancements and future trends
US20060058710A1 (en) Ultrasound wound treatment method and device using standing waves
US20030130707A1 (en) Non-invasive capacitively coupled electrical stimulation device for treatment of soft tissue wounds
US7429249B1 (en) Method for cavitation-induced tissue healing with low intensity ultrasound
US20020156415A1 (en) Ultrasonically enhanced substance delivery system and device
WO2000069515A1 (en) Remote and local controlled delivery of pharmaceutical compounds using electromagnetic energy
Nanda et al. Current developments using emerging transdermal technologies in physical enhancement methods.
US20140303525A1 (en) Method and device for non-invasive acoustic stimulation of stem cells and progenitor cells in a patient
US20150174388A1 (en) Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue
US20030139731A1 (en) Device for transcutaneous drug delivery and uses therefor
US20140025050A1 (en) Vacuum suction pressure device equipped with heat enabled insert

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
C14 Grant of patent or utility model