CN114796424B - Fuyankang tablet film coating liquid and preparation equipment thereof - Google Patents
Fuyankang tablet film coating liquid and preparation equipment thereof Download PDFInfo
- Publication number
- CN114796424B CN114796424B CN202210536402.8A CN202210536402A CN114796424B CN 114796424 B CN114796424 B CN 114796424B CN 202210536402 A CN202210536402 A CN 202210536402A CN 114796424 B CN114796424 B CN 114796424B
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- Prior art keywords
- mixing container
- fixedly connected
- mixing
- coating powder
- fuyankang
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- 239000007788 liquid Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000007888 film coating Substances 0.000 title claims abstract description 16
- 238000009501 film coating Methods 0.000 title claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 111
- 238000003756 stirring Methods 0.000 claims abstract description 36
- 238000007789 sealing Methods 0.000 claims abstract description 8
- 239000011248 coating agent Substances 0.000 abstract description 68
- 238000000576 coating method Methods 0.000 abstract description 68
- 239000000843 powder Substances 0.000 abstract description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 33
- 239000008213 purified water Substances 0.000 abstract description 28
- 230000000694 effects Effects 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 2
- 238000007599 discharging Methods 0.000 description 6
- 238000005381 potential energy Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000002161 passivation Methods 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/537—Salvia (sage)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
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- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K9/2893—Tablet coating processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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Abstract
The invention belongs to the technical field of medicine preparation, in particular to a film coating liquid of Fuyankang tablets and preparation equipment thereof, comprising a sealing cover and a mixing container; the sealing cover is connected to the top of the mixing container in a fit way; the bottom of the mixing container is provided with a base, and the top surface of the middle part of the base is fixedly connected with a screw rod; the screw rod is in threaded connection with the bottom of the mixing container; through setting up mixing vessel to and set up the hob in mixing vessel bottom, artificially push down mixing vessel, in driving the rotation ring rotation in the mixing vessel and inlaying the shell, utilize the magnetic force of a magnetic path and No. two magnetic paths to be connected, the accessible hob drives the rotation ring and rotates, and then drives stirring vane and rotate in mixing vessel, utilize stirring vane to rotate for the purified water that is located mixing vessel flows, and then produces the vortex, leading-in coating powder later, can avoid the coating powder adhesion on mixing vessel inner wall, realizes simultaneously the mixing effect to coating powder and purified water.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and in particular relates to a film coating liquid for Fuyankang tablets and preparation equipment thereof.
Background
The coating is a pharmaceutical process for coating a film forming material on the outer surface of a solid medicine by using specific equipment, and aims at the production process of the Fuyankang tablet, the Fuyankang tablet is divided into Chinese medicinal preparations after being tabletted by a film coating liquid, and the Fuyankang tablet contains a large amount of sucrose in a prescription, has strong hygroscopicity and is easy to deteriorate.
When the coating operation is carried out, the tablets are required to be tableted and then sub-packaged by film coating liquid, wherein the film coating liquid is a plastic film layer attached to the surface of the tablets, and before the coating operation is carried out, a coating film is required to be prepared.
In the prior art, when the coating film is prepared, as the coating powder and the passivation water are required to be mixed for preparation of the traditional coating film, when the coating powder is driven by a stirring shaft to be mixed and melted in the passivation water by the traditional mixing preparation equipment, the coating powder is inevitably contacted with the stirring shaft in the middle of the mixing container and adhered to the surface of the stirring shaft when the coating powder is added into the mixing container, so that the utilization rate of the coating powder is low, and the concentration of the prepared coating liquid is reduced.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention solves the problems that coating powder is easy to adhere to a stirring shaft when the existing coating liquid is prepared, so that the utilization rate of the coating powder is low, and the concentration of the prepared coating liquid is reduced.
The technical scheme adopted for solving the technical problems is as follows:
the film coating liquid for the Fuyankang tablet consists of the following raw materials in percentage by weight:
film forming material: 50% -60%;
and (3) a plasticizer: 28% -30%;
coloring agent: 10% -12%;
defoaming agent: 1% -2%;
wherein, the film forming material adopts modified methyl cellulose-HPMC; the plasticizer is composed of polyethylene glycol, talcum powder and titanium dioxide.
The preparation equipment of the film coating liquid of the Fuyankang tablet comprises a sealing cover and a mixing container; the sealing cover is connected to the top of the mixing container in a fit way; the bottom of the mixing container is provided with a base, and the top surface of the middle part of the base is fixedly connected with a screw rod; the screw rod is in threaded connection with the bottom of the mixing container; an embedded shell is fixedly connected inside the mixing container, and a rotating ring is rotationally connected inside the embedded shell; the outer side of the embedded shell is rotationally connected with a stirring blade, and the stirring blade is movably connected in the mixing container; the inside wall of swivel ring is provided with the internal thread, just the hob with swivel ring threaded connection is pouring coating powder into mixing vessel afterwards, utilizes the vortex state of purified water, avoids coating powder and mixing vessel inner wall contact, and then leads to the utilization ratio decline of coating powder.
Preferably, the top surface around the base is fixedly connected with a plurality of groups of straight rods which are circumferentially and symmetrically arranged; the tops of the straight rods are movably connected with a connecting plate, and the other ends of the connecting plates are fixedly connected with guard rings; the bottom of the mixing container is attached to the top of the guard ring; the straight rod is sleeved with a spring, two ends of the spring are fixedly connected with a connecting plate and a base respectively, when the mixing container moves downwards, the mixing container is driven to move upwards, and then the spiral rod and the rotating ring are driven to move reversely, so that the rotating ring rotates reversely, and then the stirring blades are driven to rotate reversely, so that vortex is reversed, and after coating powder and purified water are mixed, the coating powder and purified water can be fully mixed.
Preferably, the outer side of the embedded shell is fixedly connected with a first fixing seat; the stirring blade is connected in the first fixed seat in a sliding way; the inner side of the embedded shell is fixedly connected with a second fixing seat, and the rotating ring is connected in the second fixing seat in a sliding manner; one end of the stirring blade, which is close to the first fixing seat, is clamped with a first magnetic block, and one end of the rotating ring, which is close to the second fixing seat, is clamped with a second magnetic block; the first magnetic block is magnetically connected with the second magnetic block, so that when the follow-up coating powder is poured into the mixing container, the coating powder can be driven by purified water in a vortex state, the problem of adhesion caused by contact with the inner side wall of the mixing container is avoided, and the utilization efficiency of the coating powder is improved.
Preferably, the top of the sealing cover is provided with symmetrically arranged blanking grooves; the vertical line of the blanking groove is positioned between the side wall of the mixing container and the embedded shell; a slope block is arranged at the bottom of the mixing container; the outside of the top of the mixing container is fixedly connected with symmetrically arranged handles, wherein the discharging groove is in slope arrangement, so that when the coating powder is poured into the mixing container, the coating powder can enter purified water in a vortex state along the discharging groove.
The invention has the technical effects and advantages that:
according to the film coating liquid for Fuyankang tablets and the preparation equipment thereof, provided by the invention, the mixing container and the screw rod arranged at the bottom of the mixing container are arranged, the mixing container is manually pressed downwards, the rotating ring in the mixing container is driven to rotate in the embedded shell, the first magnetic block and the second magnetic block are connected by magnetic force, the screw rod can drive the rotating ring to rotate, the stirring blades are driven to rotate in the mixing container, the stirring blades are driven to rotate, purified water in the mixing container flows, vortex is generated, coating powder is led in, the coating powder is prevented from adhering to the inner wall of the mixing container, and the mixing effect of the coating powder and the purified water is realized.
Drawings
The invention is further described below with reference to the accompanying drawings.
FIG. 1 is a first perspective view of the present invention;
FIG. 2 is a second perspective view of the present invention;
FIG. 3 is a third perspective view of the present invention;
FIG. 4 is a perspective view of a closure of the present invention;
FIG. 5 is a cross-sectional view of the present invention;
fig. 6 is an enlarged schematic view of the structure of the portion a of fig. 5 in the present invention.
In the figure: 11. a cover; 12. discharging groove; 13. a handle; 14. a mixing vessel; 15. an inner embedded shell; 16. a first fixing seat; 17. a second fixing seat; 18. slope blocks; 21. a guard ring; 22. a connecting plate; 23. a base; 24. a straight rod; 25. a spring; 26. a screw rod; 3. stirring blades; 31. a first magnetic block; 4. a rotating ring; 41. and a second magnetic block.
Detailed Description
The invention is further described in connection with the following detailed description in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
The invention relates to a film coating liquid for Fuyankang tablets, which comprises the following raw materials in parts by weight:
film forming material: 56% of a glass fiber;
and (3) a plasticizer: 30%;
coloring agent: 12%;
defoaming agent: 2%;
wherein, the film forming material adopts modified methyl cellulose-HPMC; the plasticizer is composed of polyethylene glycol, talcum powder and titanium dioxide.
As shown in fig. 1-6, a preparation device of a film coating liquid of Fuyankang tablet comprises a sealing cover 11 and a mixing container 14; the cover 11 is in fit connection with the top of the mixing container 14; a base 23 is arranged at the bottom of the mixing container 14, and a screw rod 26 is fixedly connected to the top surface of the middle part of the base 23; the screw 26 is screwed on the bottom of the mixing container 14; an embedded shell 15 is fixedly connected inside the mixing container 14, and a rotating ring 4 is rotatably connected inside the embedded shell 15; the outer side of the embedded shell 15 is rotatably connected with a stirring blade 3, and the stirring blade 3 is movably connected in the mixing container 14; the inner side wall of the rotating ring 4 is provided with an internal thread, and the screw rod 26 is in threaded connection with the rotating ring 4.
Specifically, as the conventional coating powder preparation method drives the coating powder to be fused with the passivation water through the rotation of the stirring shaft, when a sufficient amount of coating powder is input, the coating powder is easy to adhere to the stirring shaft in the mixing container 14, so that the utilization rate of the coating powder is reduced, and the concentration of the prepared coating liquid is reduced, in the scheme, the cover 11 is fit on the top of the mixing container 14 in the process of processing the coating liquid, firstly, a certain amount of purified water is added into the mixing container 14, then the mixing container 14 is pressed downwards under the action of manpower, so that the mixing container 14 moves on the base 23, when the mixing container 14 moves on the base 23, the screw rod 26 positioned on the base 23 penetrates through the mixing container 14 and drives the rotating ring 4 in the mixing container 14 to rotate, by using the threaded connection between the rotating ring 4 and the screw rod 26, and the rotating ring 4 is rotatably connected to the inner wall of the inner embedded shell 15, when the screw rod 26 penetrates through the inner embedded shell 15, the rotating ring 4 is driven to rotate, and then the stirring blade 3 in the mixing container 14 is indirectly driven to rotate, so that purified water in the mixing container 14 can be stirred, the purified water in the mixing container 14 flows to generate vortex, then coating powder is poured into the mixing container 14, the vortex state of the purified water is utilized to prevent the coating powder from contacting with the inner wall of the mixing container 14, and further the utilization rate of the coating powder is reduced, compared with the traditional method that passivation water and the coating powder are driven to be mixed by utilizing a stirring shaft, the stirring shaft is arranged in the mixing container 14, therefore, the condition that the stirring shaft contacts and adheres to the coating powder cannot be avoided when the coating powder is input, the scheme utilizes the mutual motion relation of the rotating ring 4 and the screw rod 26, the stirring blade 3 at the bottom of the mixing container 14 can be driven to rotate, so that stirring effect on passivation water is realized, vortex is generated, and meanwhile, a stirring shaft is canceled, so that coating powder can be freely put into the mixing container 14, and the preparation of the coating powder is completed.
As an implementation mode of the invention, a plurality of groups of straight rods 24 which are circumferentially and symmetrically arranged are fixedly connected to the top surface of the periphery of the base 23; the tops of the straight rods 24 are movably connected with a connecting plate 22, and the other ends of the connecting plates 22 are fixedly connected with a guard ring 21; the bottom of the mixing container 14 is attached to the top of the guard ring 21; the straight rod 24 is sleeved with a spring 25, and two ends of the spring 25 are fixedly connected with the connecting plate 22 and the base 23 respectively.
Specifically, when the mixing container 14 is manually driven to move downwards, the guard ring 21 at the bottom of the mixing container 14 is driven to move downwards by the mixing container 14, at this time, the connecting plates 22 around the guard ring 21 move on the straight rods 24 at the top of the base 23, meanwhile, when the guard ring 21 drives the connecting plates 22 to move downwards on the straight rods 24, the springs 25 on the straight rods 24 compress and generate elastic potential energy, the buffering effect of the guard ring 21 is realized by using the elastic potential energy generated by the springs 25, namely, the buffering effect of the mixing container 14 is realized, meanwhile, under the elastic potential energy of the springs 25, when the mixing container 14 moves downwards, the mixing container 14 is driven to move upwards, the spiral rods 26 and the rotating ring 4 are driven to move reversely, so that the rotating ring 4 rotates reversely, and the stirring blades 3 are driven to rotate reversely, so that vortex is reversed, and after the coating powder and the purified water are mixed, the coating powder and the purified water can be fully mixed.
As an embodiment of the present invention, the outer side of the embedded shell 15 is fixedly connected with a first fixing seat 16; the stirring blade 3 is connected in the first fixed seat 16 in a sliding way; the inner side of the embedded shell 15 is fixedly connected with a second fixing seat 17, and the rotary ring 4 is connected in the second fixing seat 17 in a sliding manner; one end of the stirring blade 3, which is close to the first fixing seat 16, is clamped with a first magnetic block 31, and one end of the rotating ring 4, which is close to the second fixing seat 17, is clamped with a second magnetic block 41; the first magnetic block 31 is magnetically connected with the second magnetic block 41.
Specifically, when the rotating ring 4 is driven by the screw rod 26 to rotate in the second fixing seat 17, the stirring blade 3 sliding in the first fixing seat 16 can rotate under the magnetic connection effect of the first magnetic block 31 and the second magnetic block 41, so that purified water in the mixing container 14 can be stirred to flow, the purified water in the mixing container 14 is driven to flow, the vortex effect is generated, and the coating powder can be driven by the purified water in the vortex state when the coating powder is poured into the mixing container 14, so that the problem of adhesion caused by contact with the inner side wall of the mixing container 14 is avoided, and the utilization efficiency of the coating powder is improved.
As an embodiment of the present invention, the top of the cover 11 is provided with symmetrically arranged blanking slots 12; the vertical line of the blanking groove 12 is positioned between the side wall of the mixing container 14 and the embedded shell 15; the bottom of the mixing vessel 14 is provided with a ramp 18; the outer side of the top of the mixing container 14 is fixedly connected with symmetrically arranged handles 13.
Specifically, when the coating powder is poured, the coating powder is poured into the mixing container 14 through the discharging groove 12, wherein the discharging groove 12 is arranged in a slope manner, so that when the coating powder is poured into the mixing container 14, the coating powder can enter purified water in a vortex state along the discharging groove 12.
In order to avoid low utilization rate of coating powder caused by adhesion of the coating powder to the inner side wall of the mixing container 14 when the coating liquid is poured into the mixing container 14, the device firstly adds quantitative purified water into the mixing container 14, then presses down the mixing container 14 under the artificial action, so that the mixing container 14 moves on the base 23, when the mixing container 14 moves on the base 23, a screw rod 26 positioned on the base 23 penetrates through the mixing container 14 and drives a rotating ring 4 in the mixing container 14 to rotate, the rotating ring 4 is rotationally connected to the inner wall of an inner embedded shell 15 by utilizing the threaded connection between the rotating ring 4 and the screw rod 26, and when the screw rod 26 penetrates through the inner embedded shell 15, the rotating ring 4 is driven to rotate, and then the stirring blade 3 in the mixing container 14 is indirectly driven to rotate, so that the purified water in the mixing container 14 can be stirred, the purified water in the mixing container 14 flows to generate vortex, and then the coating powder is prevented from contacting the inner wall of the mixing container 14 by utilizing the vortex state of the purified water, so that the utilization rate of the coating powder is reduced;
when the rotating ring 4 is driven by the screw rod 26 to rotate in the second fixing seat 17, the stirring blade 3 sliding in the first fixing seat 16 can rotate under the magnetic force connection effect of the first magnetic block 31 and the second magnetic block 41, so that purified water in the mixing container 14 can be stirred to flow, the purified water in the mixing container 14 can be driven to flow, the eddy effect is generated, and the coating powder can be driven by the purified water in the eddy state when the coating powder is poured into the mixing container 14, so that the problem of adhesion caused by contact of the coating powder on the inner side wall of the mixing container 14 is solved, and the utilization efficiency of the coating powder is improved;
when the mixing container 14 is manually driven to move downwards, the guard ring 21 positioned at the bottom of the mixing container 14 is driven by the mixing container 14 to move downwards, at the moment, the connecting plates 22 around the guard ring 21 move on the straight rods 24 at the top of the base 23, meanwhile, when the guard ring 21 drives the connecting plates 22 to move downwards on the straight rods 24, the springs 25 positioned on the straight rods 24 compress and generate elastic potential energy, the elastic potential energy generated by the springs 25 is utilized to realize the buffering effect on the guard ring 21, namely the buffering effect on the mixing container 14, and meanwhile, under the elastic potential energy of the springs 25, when the mixing container 14 moves downwards, the mixing container 14 is driven to move upwards, the spiral rods 26 and the rotating ring 4 are driven to move reversely, so that the rotating ring 4 is driven to rotate reversely, and the stirring blades 3 are driven to rotate reversely, so that vortex is reversed, and after the coating powder and purified water are mixed, the coating powder and the purified water can be fully mixed.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (4)
1. A preparation device of a film coating liquid of Fuyankang tablets is characterized in that: comprising a closure (11) and a mixing container (14); the sealing cover (11) is in fit connection with the top of the mixing container (14); a base (23) is arranged at the bottom of the mixing container (14), and a screw rod (26) is fixedly connected to the top surface of the middle part of the base (23); the screw rod (26) is connected with the bottom of the mixing container (14) in a threaded manner; an embedded shell (15) is fixedly connected inside the mixing container (14), and a rotating ring (4) is rotatably connected inside the embedded shell (15); the outer side of the embedded shell (15) is rotationally connected with a stirring blade (3), and the stirring blade (3) is movably connected in the mixing container (14); the inner side wall of the rotary ring (4) is provided with an internal thread, and the screw rod (26) is in threaded connection with the rotary ring (4);
a first fixing seat (16) is fixedly connected to the outer side of the embedded shell (15); the stirring blade (3) is connected in the first fixed seat (16) in a sliding way; a second fixing seat (17) is fixedly connected to the inner side of the embedded shell (15), and the rotary ring (4) is connected in the second fixing seat (17) in a sliding manner; one end, close to the first fixed seat (16), of the stirring blade (3) is clamped with a first magnetic block (31), and one end, close to the second fixed seat (17), of the rotating ring (4) is clamped with a second magnetic block (41); the first magnetic block (31) is magnetically connected with the second magnetic block (41).
2. The preparation device of the film coating liquid for Fuyankang tablets according to claim 1, which is characterized in that: a plurality of groups of straight rods (24) which are circumferentially and symmetrically arranged are fixedly connected to the top surface around the base (23); the tops of the straight rods (24) are movably connected with a connecting plate (22), and the other ends of the connecting plate (22) are fixedly connected with a guard ring (21).
3. The preparation device of the film coating liquid for Fuyankang tablets according to claim 2, which is characterized in that: the bottom of the mixing container (14) is attached to the top of the guard ring (21); the straight rod (24) is sleeved with a spring (25), and two ends of the spring (25) are fixedly connected with a connecting plate (22) and a base (23) respectively.
4. The preparation device of the film coating liquid for Fuyankang tablets according to claim 3, which is characterized in that: the top of the sealing cover (11) is provided with symmetrically arranged blanking grooves (12); the vertical line of the blanking groove (12) is positioned between the side wall of the mixing container (14) and the embedded shell (15); a slope block (18) is arranged at the bottom of the mixing container (14); the outside of the top of the mixing container (14) is fixedly connected with symmetrically arranged handles (13).
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1552368A (en) * | 2003-06-03 | 2004-12-08 | 毛友昌 | Fuyankang pills against gynecologic inflammation and their preparation |
CN103691339A (en) * | 2013-12-31 | 2014-04-02 | 昆明特康科技有限公司 | Solid-liquid mixing equipment |
CN110840852A (en) * | 2019-10-16 | 2020-02-28 | 河北天成药业股份有限公司 | Metformin hydrochloride tablet and production process and production equipment thereof |
CN210934670U (en) * | 2019-11-08 | 2020-07-07 | 福建省尤溪县华鑫化工有限责任公司 | Mixing device for producing polyaluminium chloride |
CN214159232U (en) * | 2020-12-15 | 2021-09-10 | 楚天科技股份有限公司 | Device for delivering drug coating solution |
CN216223863U (en) * | 2021-09-06 | 2022-04-08 | 茂名市和亿化工有限公司 | Multi-blade stirring device for calcium phosphoaluminate hydrate |
-
2022
- 2022-05-17 CN CN202210536402.8A patent/CN114796424B/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1552368A (en) * | 2003-06-03 | 2004-12-08 | 毛友昌 | Fuyankang pills against gynecologic inflammation and their preparation |
CN103691339A (en) * | 2013-12-31 | 2014-04-02 | 昆明特康科技有限公司 | Solid-liquid mixing equipment |
CN110840852A (en) * | 2019-10-16 | 2020-02-28 | 河北天成药业股份有限公司 | Metformin hydrochloride tablet and production process and production equipment thereof |
CN210934670U (en) * | 2019-11-08 | 2020-07-07 | 福建省尤溪县华鑫化工有限责任公司 | Mixing device for producing polyaluminium chloride |
CN214159232U (en) * | 2020-12-15 | 2021-09-10 | 楚天科技股份有限公司 | Device for delivering drug coating solution |
CN216223863U (en) * | 2021-09-06 | 2022-04-08 | 茂名市和亿化工有限公司 | Multi-blade stirring device for calcium phosphoaluminate hydrate |
Non-Patent Citations (1)
Title |
---|
曹所娣等.妇炎康片的工艺研究.上海医药.2006,第27卷(第06期),第280-282页. * |
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