CN114796360A - Traditional Chinese medicine for treating gastroduodenal ulcer - Google Patents
Traditional Chinese medicine for treating gastroduodenal ulcer Download PDFInfo
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- CN114796360A CN114796360A CN202210520566.1A CN202210520566A CN114796360A CN 114796360 A CN114796360 A CN 114796360A CN 202210520566 A CN202210520566 A CN 202210520566A CN 114796360 A CN114796360 A CN 114796360A
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Abstract
The invention relates to a traditional Chinese medicine for treating gastroduodenal ulcer, which can effectively solve the problem of medication of gastroduodenal ulcer and adopts the technical scheme that the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 30-50g of herba patriniae, 20-40g of white paeony root, 20-40g of pseudo-ginseng, 20-30g of rhizoma corydalis, 20-30g of medicated leaven, 20-30g of cassia twig and 15-25g of liquorice.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine for treating gastroduodenal ulcer.
Background
Gastroduodenal ulcer is a common disease of the digestive tract, generally, after cerebral cortex receives external bad stimulation, spasm of blood vessels and muscles of stomach and duodenal wall is caused, cell nutrition of gastrointestinal wall is disturbed, and resistance of gastrointestinal mucosa is reduced, so that gastrointestinal mucosa wall is easily digested by gastric juice to form ulcer, and diseases such as helicobacter pylori infection, gastric dysfunction and virus infection, or other factors such as diet, long-term administration of irritant drugs, mental factors and the like cause abnormal secretion of gastric acid and pepsin, and excessive secretion of gastric acid erodes gastroduodenal mucosa to cause ulcer.
At present, almost all duodenal ulcers and a large part of gastric ulcers are caused by helicobacter pylori, so that the helicobacter pylori is eradicated firstly in the treatment of the duodenal ulcers and one to two acid-inhibiting drugs are used in a triple or quadruple therapy combining two antibiotics, but the antibiotics are used to generate drug resistance and are easy to relapse, the subsequent treatment effect of the ulcers is poor, the disease is easy to repeat, other ulcers with few causes are difficult to treat, and no particularly good treatment drugs exist at present.
Disclosure of Invention
In view of the above situation, the present invention aims to provide a traditional Chinese medicine for treating gastroduodenal ulcer, which can effectively solve the problem of medication of gastroduodenal ulcer.
The technical scheme of the invention is that the traditional Chinese medicine is prepared from the following raw material medicines by weight: 30-50g of patrinia, 20-40g of white paeony root, 20-40g of pseudo-ginseng, 20-30g of corydalis tuber, 20-30g of medicated leaven, 20-30g of cassia twig and 15-25g of liquorice, mixing the raw materials together, adding water for immersion, boiling with strong fire, keeping the boiling with slow fire for 25-40min, and filtering to obtain a first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding 0.1-1% magnesium stearate and 8-15% adjuvants, mixing, granulating, drying, tabletting, and coating.
The auxiliary material is one or a mixture of more than two of corn starch, dextrin or powdered sugar in any proportion.
The traditional Chinese medicine composition has the advantages of reasonable formula, rich raw materials, and combination of the raw materials, has the effects of astringing to stop bleeding, promoting granulation and clearing and activating the channels and collaterals, can be effectively used for treating gastroduodenal ulcer, has definite curative effect and no toxic or side effect, and is an innovation on gastroduodenal ulcer medicines.
Detailed Description
The following examples further illustrate the embodiments of the present invention in detail.
Example 1
When the invention is implemented, the invention can be prepared by the following raw material medicaments by weight: mixing herba Patriniae 30g, radix Paeoniae alba 20g, Notoginseng radix 20g, rhizoma corydalis 20g, Massa Medicata Fermentata 20g, ramulus Cinnamomi 20g, and Glycyrrhrizae radix 15g, soaking in water, boiling with strong fire, keeping boiling with slow fire for 25-40min, and filtering to obtain first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding 0.3% magnesium stearate and 9% corn starch, mixing, granulating, drying, tabletting to 100 tablets, and coating.
Example 2
When the invention is concretely implemented, the medicine can also be prepared from the following raw material medicines by weight: 40g of herba patriniae, 30g of white paeony root, 30g of pseudo-ginseng, 25g of rhizoma corydalis, 25g of medicated leaven, 25g of cassia twig and 20g of liquorice, mixing the raw materials together, adding water for immersion, boiling with strong fire, then keeping the boiling with slow fire for 25-40min, and filtering to obtain a first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding magnesium stearate 0.5% and corn starch 11% and dextrin, mixing, granulating, drying, tabletting to obtain 150 tablets, and coating.
Example 3
When the invention is implemented, the invention can also be prepared from the following raw material medicaments in part by weight: 50g of herba patriniae, 40g of white paeony root, 40g of pseudo-ginseng, 30g of rhizoma corydalis, 30g of medicated leaven, 30g of cassia twig and 25g of liquorice, mixing the raw materials together, adding water for immersion, boiling with strong fire, then keeping the boiling with slow fire for 25-40min, and filtering to obtain a first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding magnesium stearate 0.8% and corn starch 13%, dextrin and sugar powder, mixing, granulating, drying, tabletting to obtain 200 tablets, and coating.
In the formula of the invention, the formula comprises the following components:
herba Patriniae: cool in nature, pungent and bitter in flavor. It enters stomach meridian, large intestine meridian and liver meridian. Clearing away heat and toxic material, removing blood stasis and expelling pus. Belonging to the category of heat-clearing herbs. It can be used for treating appendicitis, dysentery, enteritis, hepatitis, conjunctivitis, and puerperal abdominal pain due to blood stasis. The fresh products with proper dosage are pounded and applied to the affected part to treat carbuncle, swelling and furuncle.
White peony root: bitter and sour in taste, slightly cold in nature. It enters liver and spleen meridians. Nourish blood and regulate menstruation, astringe yin and check sweating, soften liver and relieve pain, and calm liver yang. Can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, and vertigo.
Pseudo-ginseng: the pseudo-ginseng is warm in nature and pungent in taste, has remarkable effects of promoting blood circulation to remove blood stasis, and relieving swelling and pain, and is mainly used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, thoracico-abdominal pain and traumatic swelling and pain.
Rhizoma corydalis: warm in nature, bitter and pungent in flavor, enter heart, liver and spleen meridians. Has effects in promoting blood circulation, activating qi-flowing, and relieving pain. Can be used for treating various pain syndromes, such as thoracic obstruction, heart pain, heat syndrome, cold syndrome, qi stagnation, blood stasis, abdominal pain due to hernia, rheumatic arthralgia, dysmenorrhea, and puerperal stagnation.
Medicated leaven: enter spleen and stomach meridians. Sweet and pungent, warm. Strengthen spleen and stomach, promote digestion and regulate middle energizer. It is indicated for food stagnation, fullness in chest, abdominal distention, emesis, dysentery, puerperal abdominal pain due to blood stasis, and abdominal mass and accumulation in children.
Cassia twig: pungent, sweet and warm. It enters heart, lung and bladder meridians. Has the effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm and fluid retention, edema and palpitation.
Licorice root: sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
The medicine has the functions of expelling wind-damp, promoting menstruation to relieve menalgia and improving blood circulation of mucosa, and is generally used for treating wind-damp or rheumatoid arthritis. It also has analgesic and hemostatic effects, and can promote the resolution of inflammation and healing of ulcer.
In conclusion, the patrinia herb is a monarch drug for clearing heat and removing toxicity, removing stasis and expelling pus, is a pseudo-ginseng and corydalis tuber for promoting qi circulation, dredging collaterals and relieving pain, has an obvious analgesic effect, is an adjuvant drug for invigorating spleen and stomach, and promoting digestion and regulating middle warmer, is an adjuvant drug for relieving exterior syndrome and expelling pathogenic factors from muscles, warming channels and dredging collaterals, supporting yang and regulating qi, is an adjuvant drug for nourishing yin and liver, is matched with liquorice for relieving spasm and pain, is a guiding drug for purging and benefiting salt, has the effects of astringing and stopping bleeding, promoting granulation, and clearing and activating the channels and collaterals, can be effectively used for treating gastroduodenal ulcer, has exact curative effect and no toxic or side effect, and has the following relevant test data:
first, clinical data
1. 120 patients with gastroduodenal ulcer, 78 men and 42 women are selected, the age is 20-60 years, the course of disease is 3 months-15 years, and the average course of disease is 5.1 +/-2.2 years.
II, diagnosis standard
2.1 Chinese medicine symptom standard:
referring to the Chinese medical science society of spleen and stomach diseases, the treatise on the diagnosis and treatment consensus of peptic ulcer in traditional Chinese medicine:
the main symptoms are: epigastric pain (distending pain, stabbing pain, dull pain, megalgia, and pressing and tenderness), abdominal distention, gastric acid regurgitation, sighing, belch, anorexia, bitter taste of mouth, and dry stool.
Secondary symptoms: urgency, irritability, aversion to cold, cold limbs, dizziness or limb fatigue, vomiting of clear water, loose stool, diarrhea, dysphoria, irritability, constipation, cold drink preference, insomnia, dreaminess, feverish sensation in the palms and soles, and yellowish urine.
It can be diagnosed by adding 2 items of the primary syndrome plus 1 item of the secondary syndrome, or adding 2 items of the primary syndrome plus 1 item of the secondary syndrome.
2.2 Western diagnostic standards
1) The patients with ulcer are confirmed by gastroscopy.
2) The patients with skin and external diseases are confirmed by X-ray barium meal examination.
3) Urease test or nuclide-labeled C13 breath test: aims to detect whether helicobacter pylori infection exists or not, and is mainly used for evaluating the curative effect of the helicobacter pylori eradication treatment.
Third, treatment scheme
For patients with positive helicobacter pylori, after the patients are treated radically by an antibiotic four-combination therapy, the traditional Chinese medicine tablets prepared in the embodiment 2 are taken, and the patients without positive helicobacter pylori are directly taken, wherein 3 tablets are taken each time, 1 time is taken in the morning, the noon and the evening, 20 days are a treatment course, the treatment effect is counted after 2 treatment courses, and the patients are not affected with pungent foods such as tobacco, wine, spicy oil and greasy food during the treatment course.
Fourth, therapeutic effect judgment standard
And (3) curing: disappearance of ulcer through gastroscopy and X-ray barium meal examination;
the obvious improvement: the ulcer surface is obviously reduced;
improvement: the ulcer surface is reduced;
and (4) invalidation: the size of the ulcer was unchanged.
Fifth, the therapeutic effect
Among 120 patients, 28 patients are cured, 36 patients are obviously improved, 54 patients are improved, 2 patients are ineffective, the total effective rate is 98.3 percent, no obvious side effect is seen in the treatment process, the statistical data are shown in table 1,
| number of total cases | Cure of disease | Obvious improvement | Improvement of life | Invalidation | Total effective rate |
| 120 | 28 | 36 | 54 | 2 | 98.3% |
Through repeated experiments, the products prepared by other embodiments of the invention can obtain the same or similar beneficial effects as the experimental results.
Sixth, conclusion
Through the clinical research on the treatment of the gastroduodenal ulcer, the invention has the advantages that the combination of the medicines has the effects of astringing to stop bleeding, promoting regeneration of slough and clearing and activating the channels and collaterals, the total effective rate is 98.3%, the curative effect of treating the gastroduodenal ulcer is obvious, no adverse reaction and toxic or side effect are seen in clinic, the medicine is safe and reliable, the medicine is an innovation on the medicine for treating the gastroduodenal ulcer, and the medicine has practical clinical significance and popularization value.
Claims (4)
1. The traditional Chinese medicine for treating gastroduodenal ulcer is characterized by being prepared from the following raw material medicines in parts by weight: 30-50g of patrinia, 20-40g of white paeony root, 20-40g of pseudo-ginseng, 20-30g of corydalis tuber, 20-30g of medicated leaven, 20-30g of cassia twig and 15-25g of liquorice, mixing the raw materials together, adding water for immersion, boiling with strong fire, keeping the boiling with slow fire for 25-40min, and filtering to obtain a first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding 0.1-1% magnesium stearate and 8-15% adjuvants, mixing, granulating, drying, tabletting, and coating.
2. The traditional Chinese medicine for treating gastroduodenal ulcer as claimed in claim 1, is characterized by being prepared from the following raw materials by weight: mixing herba Patriniae 30g, radix Paeoniae alba 20g, Notoginseng radix 20g, rhizoma corydalis 20g, Massa Medicata Fermentata 20g, ramulus Cinnamomi 20g, and Glycyrrhrizae radix 15g, soaking in water, boiling with strong fire, keeping boiling with slow fire for 25-40min, and filtering to obtain first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding 0.3% magnesium stearate and 9% corn starch, mixing, granulating, drying, tabletting to 100 tablets, and coating.
3. The traditional Chinese medicine for treating gastroduodenal ulcer according to claim 1, which is prepared from the following raw medicines in parts by weight: 40g of herba patriniae, 30g of white paeony root, 30g of pseudo-ginseng, 25g of rhizoma corydalis, 25g of medicated leaven, 25g of cassia twig and 20g of liquorice, mixing the raw materials together, adding water for immersion, boiling with strong fire, then keeping the boiling with slow fire for 25-40min, and filtering to obtain a first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding magnesium stearate 0.5% and corn starch 11% and dextrin, mixing, granulating, drying, tabletting to obtain 150 tablets, and coating.
4. The traditional Chinese medicine for treating gastroduodenal ulcer according to claim 1, which is prepared from the following raw medicines in parts by weight: 50g of herba patriniae, 40g of white paeony root, 40g of pseudo-ginseng, 30g of rhizoma corydalis, 30g of medicated leaven, 30g of cassia twig and 25g of liquorice, mixing the raw materials together, adding water for immersion, boiling with strong fire, then keeping the boiling with slow fire for 25-40min, and filtering to obtain a first filtrate; soaking the residue in water, boiling with strong fire, keeping boiling with slow fire for 15-25min, filtering to obtain second filtrate, mixing the second filtrates, concentrating to obtain extract with relative density of 1.1-1.2 at 50 deg.C, adding magnesium stearate 0.8% and corn starch 13%, dextrin and sugar powder, mixing, granulating, drying, tabletting to obtain 200 tablets, and coating.
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