CN114786781A - 毛发增强组合物 - Google Patents
毛发增强组合物 Download PDFInfo
- Publication number
- CN114786781A CN114786781A CN202080086024.7A CN202080086024A CN114786781A CN 114786781 A CN114786781 A CN 114786781A CN 202080086024 A CN202080086024 A CN 202080086024A CN 114786781 A CN114786781 A CN 114786781A
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- Prior art keywords
- hair care
- care composition
- silicone
- hair
- acid
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Abstract
本发明公开了一种毛发护理组合物,该毛发护理组合物包含约0.04重量%至约2重量%的壬二酸;约0.04重量%至约1重量%的油酸;其中油酸与壬二酸之比为约1:1至约1:3,另选地约1:2.5至约1:3的油酸比壬二酸,另选地约1:2至约1:3的油酸比壬二酸,另选地约1:1.5至约1:3的油酸比壬二酸;以及含水载体。该毛发护理组合物还可包含有机硅。另外,该毛发护理组合物可包含约0.1重量%至约10重量%的阳离子表面活性剂体系。该毛发护理组合物还可包含约1%至约15%的高熔点脂肪族化合物。该毛发护理组合物提供增加的强度有益效果。这种毛发强度有益效果可以通过多种毛发护理产品递送给消费者,所述多种毛发护理产品包括但不限于调理剂、免洗型处理物和洗去型产品。
Description
技术领域
本发明涉及一种毛发护理组合物,该毛发护理组合物包含壬二酸和油酸以提供抗破损毛发强度有益效果。
背景技术
已经开发了多种方法来改善毛发的健康。一种提供毛发健康有益效果的常见方法是通过使用调理剂,诸如阳离子表面活性剂和聚合物、高熔点脂肪族化合物、低熔点油、有机硅化合物、以及它们的混合物。已知大多数这些调理剂提供各种毛发健康有益效果。然而,已经发现,毛发强度是重要的有益效果,因为其有助于毛发减少破损。消费者在毛发梳理或定型期间注意到毛发破损(通常为毛发损失)。已经发现,两种活性物质可以显著改善疲劳强度,从而使破损最小化;壬二酸和油酸。它们当组合使用时导致协同有益效果。据信它们通过不同机制起作用,壬二酸分配到毛发的蛋白质区域中并且油酸分配到脂质细胞膜复合物区域中。
发明内容
本发明公开了一种毛发护理组合物,该毛发护理组合物包含约0.04重量%至约2重量%的壬二酸;约0.04重量%至约1重量%的油酸;其中油酸与壬二酸之比为约1:1至约1:3的油酸:壬二酸;以及含水载体。
具体实施方式
虽然本说明书以特别指出并清楚地要求保护本发明的权利要求书作为结尾,但据信通过下列说明可更好地理解本发明。
本文中“包括/包含”是指可添加不影响最终结果的其它步骤和其它成分。该术语涵盖术语“由……组成”和“基本上由……组成”。
除非另外说明,否则所有百分比、份数和比率均基于本发明的组合物的总重量。所有涉及所列成分的这些重量均基于活性物质的水平,并且因此不包括可能包含在可商购获得的物质中的载体或副产物。
本文中,“混合物”是指包括物质的简单组合以及可由它们的组合产生的任何化合物。
除非另外指明,否则如本文所用,术语“分子量”或“M.Wt.”是指重均分子量。可通过凝胶渗透色谱法来测量重均分子量。
“QS”是指足量至100%。
毛发产品
毛发护理组合物包含壬二酸和油酸。毛发护理组合物还可包含选自以下的材料:阳离子表面活性剂;高熔点脂肪族化合物;有机硅;含水载体以及它们的组合。毛发护理组合物可为洗去型或免洗型处理物。毛发护理组合物可为毛发调理剂。按以下比率添加油酸和壬二酸:约1:1至约1:3,另选地约1:2.5至约1:3的油酸比壬二酸,另选地约1:2至约1:3的油酸比壬二酸,另选地约1:1.5至约1:3的油酸比壬二酸。使用在这些比率下的壬二酸和油酸导致毛发强度的协同增加。可以使用酸的组合来实现组合强度有益效果。据信两种活性物质分配到毛发的不同部分中以提供强度有益效果;油酸进入富含脂质的细胞膜复合物中并且壬二酸进入毛发的蛋白质区域中。常规漂白毛发是以1.25mg酸/g毛发投配的,其中油酸:壬二酸为1:3、1:1和3:1。表1中的数据显示了对于具有更高水平的壬二酸比油酸的酸(在相同的酸总量/克毛发下)得自比率为约1:1的有益效果以及甚至更加改善的α值。由更高的壬二酸与油酸之比产生的增加有益效果可能是分配结果,因为相对于脂质区域,纤维中存在大量蛋白质区域。
表1:(1.25mg总酸/g毛发)
毛发护理组合物包含约0.04重量%至约2重量%的壬二酸,另选地约0.1重量%至约1重量%的壬二酸。壬二酸也称为壬烯二酸并且是饱和二羧酸;购自Sigma-Aldrich。其已经用于皮肤护理产品中,以用于处理痤疮和皮肤色素沉着过度的轻度病例。
毛发护理组合物包含约0.04重量%至约2重量%的油酸,另选地约0.1重量%至约0.5重量%的油酸。油酸也称为顺式-9-十八碳烯酸,并且购自Natural Oleo Chemicals。它是在健康毛发的富含脂质的细胞膜复合物中发现的不饱和脂肪酸。
A.阳离子表面活性剂体系
本文所述的毛发护理组合物包含阳离子表面活性剂体系。阳离子表面活性剂体系可为一种阳离子表面活性剂或者两种或更多种阳离子表面活性剂的混合物。阳离子表面活性剂体系可选自:单长链烷基季铵化铵盐;单长链烷基季铵化铵盐和二长链烷基季铵化铵盐的组合;单长链烷基酰胺基胺盐;单长链烷基酰胺基胺盐和二长链烷基季铵化铵盐的组合,单长链烷基酰胺基胺盐和单长链烷基季铵化铵盐的组合。
阳离子表面活性剂体系可以按毛发护理组合物的重量计约0.1%至约10%,另选地约0.5%至约8%,另选地约0.8%至约5%,以及另选地约1.0%至约4%的水平被包含在毛发护理组合物中。
单长链烷基季铵化铵盐
可用于本文的单烷基季铵化铵盐阳离子表面活性剂是具有一条长烷基链的那些,所述长烷基链具有12至30个碳原子,16至24个碳原子,并且在一个实施方案中为C18-22烷基基团。连接到氮的其余基团独立地选自1至约4个碳原子的烷基基团,或者具有至多约4个碳原子的烷氧基、聚氧化亚烷基、烷基酰氨基、羟烷基、芳基或烷基芳基基团。
可用于本文的单长链烷基季铵化铵盐是具有式(I)的那些:
其中R75、R76、R77和R78中的一者选自12至30个碳原子的烷基基团,或者具有至多约30个碳原子的芳族基团、烷氧基基团、聚氧化亚烷基基团、烷基酰氨基基团、羟烷基基团、芳基基团或烷基芳基基团;其中R75、R76、R77和R78中的其余部分独立地选自1至约4个碳原子的烷基基团,或者具有至多约4个碳原子的烷氧基、聚氧化亚烷基、烷基酰胺基、羟烷基、芳基或烷基芳基基团;并且X-为成盐阴离子,诸如选自卤素(例如氯离子、溴离子)、乙酸根、柠檬酸根、乳酸根、乙醇酸根、磷酸根、硝酸根、磺酸根、硫酸根、烷基硫酸根和烷基磺酸根基团的那些。除了碳原子和氢原子之外,烷基基团还可包含醚键和/或酯键,以及其它基团诸如氨基基团。较长链烷基基团例如约12个或更多个碳的那些可为饱和或不饱和的。R75、R76、R77和R78中的一者可选自12至30个碳原子,16至24个碳原子,18至22个碳原子,和/或22个碳原子的烷基基团;R75、R76、R77和R78中的其余部分独立地选自CH3、C2H5、C2H4OH、以及它们的混合物;并且X选自Cl、Br、CH3OSO3、C2H5OSO3、以及它们的混合物。
此类单长链烷基季铵盐阳离子表面活性剂的非限制性示例包括:山嵛基三甲基铵盐;硬脂基三甲基铵盐;鲸蜡基三甲基铵盐;以及氢化牛脂烷基三甲基铵盐。
单长链烷基酰胺基胺盐
单长链烷基胺也适合用作阳离子表面活性剂。脂肪族伯胺、脂肪族仲胺和脂肪族叔胺是可用的。尤其可用的是具有约12至约22个碳的烷基基团的叔酰氨基胺。示例性的叔酰氨基胺包括:硬脂酰氨基丙基二甲基胺、硬脂酰氨基丙基二乙基胺、硬脂酰氨基乙基二乙基胺、硬脂酰氨基乙基二甲基胺、棕榈酰氨基丙基二甲基胺、棕榈酰氨基丙基二乙基胺、棕榈酰氨基乙基二乙基胺、棕榈酰氨基乙基二甲基胺、二十二烷酰氨基丙基二甲基胺、二十二烷酰氨基丙基二乙基胺、二十二烷酰氨基乙基二乙基胺、二十二烷酰氨基乙基二甲基胺、二十烷酰氨基丙基二甲基胺、二十烷酰氨基丙基二乙基胺、二十烷酰氨基乙基二乙基胺、二十烷酰氨基乙基二甲基胺、二乙基酰氨基乙基硬脂酰胺。本发明中可用的胺公开于Nachtigal等人的美国专利4,275,055中。这些胺也可与以下酸联合使用,如l-谷氨酸、乳酸、盐酸、苹果酸、琥珀酸、乙酸、富马酸、酒石酸、柠檬酸、l-谷氨酸盐酸盐、马来酸、以及它们的混合物;在一个实施方案中,l-谷氨酸、乳酸、和/或柠檬酸。本文中的胺可用酸中的任一种部分中和,其中胺与酸的摩尔比为约1:0.3至约1:2,和/或约1:0.4至约1:1。
二长链烷基季铵化铵盐
二长链烷基季铵化铵盐可与单长链烷基季铵化铵盐或单长链烷基酰胺基胺盐组合。据信,与单独使用单烷基季铵化铵盐或单长链烷基酰胺基胺盐相比,此类组合可提供易于冲洗感。在具有单长链烷基季铵化铵盐或单长链烷基酰胺基胺盐的此类组合中,使用一定水平的二长链烷基季铵化铵盐,使得二烷基季铵化铵盐在阳离子表面活性剂体系中的重量%在约10%至约50%,和/或在约30%至约45%的范围内。
可用于本文的二烷基季铵化铵盐阳离子表面活性剂是具有两个长烷基链的那些,所述长烷基链具有12-30个碳原子,和/或16-24个碳原子,和/或18-22个碳原子。连接到氮的其余基团独立地选自1至约4个碳原子的烷基基团,或者具有至多约4个碳原子的烷氧基、聚氧化亚烷基、烷基酰氨基、羟烷基、芳基或烷基芳基基团。
可用于本文的二长链烷基季铵化铵盐是具有式(II)的那些:
其中R75、R76、R77和R78中的两个选自12至30个碳原子的烷基基团,或者具有至多约30个碳原子的芳族基团、烷氧基基团、聚氧化亚烷基基团、烷基酰氨基基团、羟烷基基团、芳基基团或烷基芳基基团;其中R75、R76、R77和R78中的其余部分独立地选自1至约4个碳原子的烷基基团,或者具有至多约4个碳原子的烷氧基、聚氧化亚烷基、烷基酰胺基、羟烷基、芳基或烷基芳基基团;并且X-为成盐阴离子,诸如选自卤素(例如氯离子、溴离子)、乙酸根、柠檬酸根、乳酸根、乙醇酸根、磷酸根、硝酸根、磺酸根、硫酸根、烷基硫酸根和烷基磺酸根基团的那些。除了碳原子和氢原子之外,烷基基团还可包含醚键和/或酯键,以及其它基团诸如氨基基团。较长链烷基基团例如约12个或更多个碳的那些可为饱和或不饱和的。R75、R76、R77和R78中的一者可选自12至30个碳原子,16至24个碳原子,18至22个碳原子,和/或22个碳原子的烷基基团;R75、R76、R77和R78中的其余部分独立地选自CH3、C2H5、C2H4OH、以及它们的混合物;并且X选自Cl、Br、CH3OSO3、C2H5OSO3、以及它们的混合物。
此类二烷基季铵盐阳离子表面活性剂包括例如二烷基(14-18)二甲基氯化铵、二牛脂烷基二甲基氯化铵、二氢化牛脂烷基二甲基氯化铵、二硬脂基二甲基氯化铵以及双十六烷基二甲基氯化铵。此类二烷基季铵化铵盐阳离子表面活性剂还包括例如不对称的二烷基季铵化铵盐阳离子表面活性剂。
B.高熔点脂肪族化合物
毛发护理组合物包含一种或多种高熔点脂肪族化合物。可用于本文的一种或多种高熔点脂肪族化合物可具有25℃或更高的熔点,并且可选自脂肪醇、脂肪酸、脂肪醇衍生物、脂肪酸衍生物、以及它们的混合物。本领域的技术人员应当理解,在说明书的这一部分中公开的化合物在某些情况下可能属于多于一种的类别,例如某些脂肪醇衍生物还可归类为脂肪酸衍生物。然而,给出的分类并不旨在对特定化合物进行限制,而是为了便于分类和命名。此外,本领域的技术人员应当理解根据双键的数目和位置以及支链的长度和位置,具有一定碳原子的某些化合物可具有低于25℃的熔点。不旨在将此类低熔点化合物包含在该部分中。高熔点化合物的非限制性示例可见于“International Cosmetic IngredientDictionary”,第五版,1993和“CTFA Cosmetic Ingredient Handbook”,第二版,1992中。
在多种高熔点脂肪族化合物中,脂肪醇适用于毛发护理组合物中。可用于本文的脂肪醇是具有约14至约30个碳原子,约16至约22个碳原子的那些。这些脂肪醇是饱和的并可为直链醇或支链醇。合适的脂肪醇包括例如鲸蜡醇、硬脂醇、山嵛醇、以及它们的混合物。
可使用高纯度的单一化合物的高熔点脂肪族化合物。还可使用选自纯鲸蜡醇、硬脂醇和山嵛醇的单一的纯脂肪醇的化合物。本文所谓“纯的”意思是化合物具有至少约90%,和/或至少约95%的纯度。当消费者冲洗掉组合物时,这些单一的高纯度化合物提供从毛发上的优良的可冲洗性。
一种或多种高熔点脂肪族化合物以按毛发护理物的重量计约0.1%至约20%,另选地约1%至约15%,以及另选地约1.5%至约8%的水平被包含在毛发护理组合物中。一种或多种高熔点脂肪族化合物可提供改善的调理有益效果,诸如向湿发施用期间的光滑感以及干发上的毛发柔软性和干发上的润湿感。
C.含水载体
毛发护理组合物包含水平为按毛发护理组合物的重量计约75%至约98%,优选地约80%至约95%的含水载体。因此,所述毛发护理组合物可以为可倾倒液体的形式(环境条件下)。含水载体可包含水,或水与有机溶剂的可混溶混合物,并且在一个方面可包含水和最小限度的或不显著浓度的有机溶剂,除了另外作为其它组分的微量成分附带地掺入组合物中的那些。
含水载体可包含低级烷基醇和多元醇的水溶液。可用于本文的低级烷基醇是具有1至6个碳的一元醇,在一个方面,为乙醇和异丙醇。可用于本文的多元醇包括丙二醇、己二醇、甘油、和丙烷二醇。
毛发护理组合物在25℃下可具有在以下范围内的pH:约2至约10,另选地约3至约8。毛发护理组合物还可有效洗出已存在的矿物和氧化还原金属沉积物,这可降低表皮失真,从而减少表皮破损和损伤。
D.凝胶基质
毛发护理组合物可包含凝胶基质。凝胶基质包含阳离子表面活性剂、高熔点脂肪族化合物、以及含水载体。
凝胶基质适于提供各种调理有益效果,诸如向湿发施用期间的光滑感和以及干发上的柔软性润湿感。为了提供上述凝胶基质,以一定水平包含阳离子表面活性剂和高熔点脂肪族化合物,使得阳离子表面活性剂与高熔点脂肪族化合物的重量比在约1:1至约1:10,和/或约1:1至约1:6的范围内。
E.附加组分
1.有机硅调理剂
毛发护理组合物可包含有机硅调理剂,所述有机硅调理剂包括有机硅化合物。有机硅化合物可包括挥发性有机硅、非挥发性有机硅、或它们的组合。如果存在挥发性有机硅,则它们通常倾向于用作可商购获得形式的非挥发性有机硅材料成分诸如硅橡胶纯胶料和有机硅树脂的溶剂或载体。有机硅化合物可包含有机硅液调理剂,并且还可包含其它成分诸如有机硅树脂,以改善有机硅液沉积效率或增强毛发光泽度。毛发护理组合物中有机硅化合物的浓度通常在约0.01重量%至约10重量%,约0.1重量%至约8重量%,约0.1重量%至约5重量%,或甚至约0.2重量%至约3重量%的范围内。适用于本文的有机硅包括但不限于PDMS(聚二甲基硅氧烷)有机硅、PQAS(有机硅季铵盐-26);PDMS、末端氨基有机硅以及它们的组合。
附加的合适有机硅化合物包括(a)第一聚硅氧烷,所述第一聚硅氧烷是非挥发性的,基本上不含氨基基团,并且具有约100,000mm2s-1至约30,000,000mm2s-1的粘度;(b)第二聚硅氧烷,所述第二聚硅氧烷是非挥发性的,基本上不含氨基基团,并且具有约5mm2s-1至约10,000mm2s-1的粘度;(c)氨基有机硅,所述氨基有机硅具有按所述氨基有机硅的重量计小于约0.5重量%的氮;(d)有机硅共聚物乳液,所述有机硅共聚物乳液具有如在25℃下测量的大于约100×106mm2s-1的内相粘度;(e)包含季铵化基团的有机硅聚合物;或(f)接枝有机硅多元醇,其中所述有机硅化合物(a)-(f)公开于美国专利申请公开2008/0292574、2007/0041929、2008/0292575和2007/0286837中,它们各自全文以引用方式并入本文。
a.第一聚硅氧烷
毛发护理组合物可包含第一聚硅氧烷。第一聚硅氧烷是非挥发性的,并且基本上不含氨基基团。第一聚硅氧烷“基本上不含氨基基团”可以是指第一聚硅氧烷包含0重量%的氨基基团。第一聚硅氧烷在25℃下具有约100,000mm2s-1至约30,000,000mm2s-1的粘度。例如,粘度可在约300,000mm2s-1至约25,000,000mm2s-1、或约10,000,000mm2s-1至约20,000,000mm2s-1的范围内。第一聚硅氧烷具有约100,000至约1,000,000的分子量。例如,分子量可在约130,000至约800,000,或约230,000至约600,000的范围内。根据一个方面,第一聚硅氧烷可为非离子的。
可用于本文的示例性第一非挥发性聚硅氧烷包括根据以下通式(I)的那些:
其中R为烷基或芳基,并且p为约1,300至约15,000,诸如约1,700至约11,000,或约3,000至约8,000的整数。Z表示封闭有机硅链末端的基团。在硅氧烷链上(R)或在硅氧烷链末端(Z)取代的烷基或芳基基团可具有任何结构,只要所得的有机硅在室温下保持液体,是可分散的,当施用至毛发时既没有刺激性、毒性也没有其它的害处,与所述组合物的其它组分相容,在正常的使用和贮藏条件下是化学稳定的,并且能够沉积在毛发上并对毛发进行调理。合适的Z基团包括羟基、甲基、甲氧基、乙氧基、丙氧基和芳氧基。每个硅原子上的两个R基团可代表相同的基团或不同的基团。两个R基团可代表相同的基团。合适的R基团包括甲基、乙基、丙基、苯基、甲基苯基和苯基甲基。示例性有机硅化合物包括聚二甲基硅氧烷、聚二乙基硅氧烷、和聚甲基苯基硅氧烷。聚二甲基硅氧烷可为第一聚硅氧烷。可用于本文的可商购获得的有机硅化合物包括例如以它们的TSF451系列购自General Electric公司的那些,和以它们的Dow Corning SH200系列购自Dow Corning的那些。
可用于本文的有机硅化合物还包括硅橡胶纯胶料(silicone gum)。如本文所用,术语“硅橡胶纯胶料”是指在25℃下具有大于或等于1,000,000mm2s-1粘度的聚有机硅氧烷物质。应当认识到,本文所述的有机硅胶也可与上述公开的有机硅化合物具有一些重叠。该重叠不旨在对这些材料中的任何一种进行限制。“硅橡胶纯胶料”通常将具有超过约165,000、一般介于约165,000和约1,000,000之间的重均分子量。具体示例包括聚二甲基硅氧烷、聚(二甲基硅氧烷-甲基乙烯基硅氧烷)共聚物、聚(二甲基硅氧烷-二苯基硅氧烷-甲基乙烯基硅氧烷)共聚物以及它们的混合物。可用于本发明的市售硅橡胶纯胶料包括,例如,购自General Electric Company的TSE200A。
b.第二聚硅氧烷
毛发护理组合物可包含第二聚硅氧烷。第二聚硅氧烷是非挥发性的,并且基本上不含氨基基团。在本发明中,第二聚硅氧烷“基本上不含氨基基团”是指第二聚硅氧烷包含0重量%的氨基基团。第二聚硅氧烷在25℃下具有约5mm2s-1至约10,000mm2s-1,诸如约5mm2s-1至约5,000mm2s-1、约10mm2s-1至约1,000mm2s-1,或约20mm2s-1至约350mm2s-1的粘度。第二聚硅氧烷具有约400至约65,000的分子量。例如,第二聚硅氧烷的分子量可在约800至约50,000,约400至约30,000,或约400至约15,000的范围内。根据一个方面,第二聚硅氧烷可为非离子的。根据另一个方面,第二聚硅氧烷可为直链有机硅。
可用于本文的示例性第二非挥发性聚硅氧烷包括根据以下通式(II)的聚烷基硅氧烷或聚芳基硅氧烷:
其中R1为烷基或芳基,并且r为约7至约850,诸如约7至约665,约7至约400,或约7至约200的整数。Z1表示封闭有机硅链末端的基团。在硅氧烷链(R1)或硅氧烷链Z1末端上取代的烷基或芳基基团可具有任何结构,只要所得有机硅在室温下保持为流体,是可分散的,当施用至毛发时既没有刺激性、毒性也没有其它危害,与所述组合物中的其它组分相容,在正常的使用和贮藏条件下是化学稳定的,并且能够沉积在毛发上并调理毛发。合适的Z1基团包括羟基、甲基、甲氧基、乙氧基、丙氧基和芳氧基。每个硅原子上的两个R1基团可代表相同的基团或不同的基团。两个R1基团可代表相同的基团。合适的R1基团包括甲基、乙基、丙基、苯基、甲基苯基和苯基甲基。示例性有机硅化合物包括聚二甲基硅氧烷、聚二乙基硅氧烷、和聚甲基苯基硅氧烷。聚二甲基硅氧烷可为第二聚硅氧烷。可用于本文的可商购获得的有机硅化合物包括例如以它们的TSF451系列购自General Electric公司的那些,和以它们的Dow Corning SH200系列购自Dow Corning的那些。
c.氨基有机硅
为了减少摩擦的有益效果,毛发护理组合物可包含氨基有机硅,所述氨基有机硅具有按所述氨基有机硅的重量计小于约0.5重量%,诸如小于约0.2重量%,或小于约0.1重量%的氮。已惊奇地发现氨基有机硅中的氮(胺官能团)水平越高趋于导致摩擦减小越少,并因此得自氨基有机硅的调理有益效果越低。为了减小摩擦的有益效果,可用于本文的氨基有机硅可具有至少一个具有大于200个硅氧烷单元的有机硅嵌段。可用于本文的氨基有机硅包括,例如,季铵化的氨基有机硅和非季铵化的氨基有机硅。
可用于本文的氨基有机硅是水不溶性的。“水不溶性氨基有机硅”是指氨基有机硅具有10g或更小每100g 25℃水,另选地5g或更小每100g 25℃水,以及另选地1g或更小每100g 25℃水的溶解度。“水不溶性氨基有机硅”是指氨基有机硅基本上不含共聚多元醇基团。如果存在共聚多元醇基团,则它们以按所述氨基有机硅的重量计小于10重量%,小于1重量%,或小于0.1重量%的水平存在。
可用于本文的氨基有机硅为符合通式(III)的那些:
(R2)aG3-a—Si(—O—SiG2)n(—O—SiGb(R2)2-b)m—O—SiG3-a(R2)a (IIII)
其中G为氢、苯基、羟基或C1-C8烷基,诸如甲基;a是值为1至3,如1的整数;b是值为0至2,如1的整数;n是1至2000,如100至1800,300至800,或500至600的数;m是值为0至1999,如0至10,或0的整数;R2为符合通式CqH2qL的一价基团,其中q为具有2至8的值的整数,并且L选自以下基团:-N(R3 2)CH2-CH2-N(R3 2)2;-N(R3)2;-N+(R3)3A-;-N(R3)CH2-CH2-N+R3H2A-;其中R3为氢、苯基、苄基或饱和烃基团,诸如约C1至约C20的烷基基团;A-为卤离子。L可为—N(CH3)2或—NH2。另选地,L可为—NH2。
具有上式的氨基有机硅以按组合物的重量计约0.1重量%至约5重量%,另选地约0.2重量%至约2重量%,另选地约0.2重量%至约1.0重量%,以及另选地约0.3重量%至约0.8重量%的水平使用。
氨基有机硅可包括符合式(III)的那些化合物,其中m=0;a=1;q=3;G=甲基;n为约1400至约1700,如约1600;并且L为-N(CH3)2或-NH2,诸如-NH2。氨基有机硅可包括符合式(III)的那些化合物,其中m=0;a=1;q=3;G=甲基;n为约400至约800,如约500至约600;并且L为L为-N(CH3)2或-NH2,诸如-NH2。因此,前述氨基有机硅可被称为末端氨基有机硅,因为有机硅链的一端或两端被含氮基团封端。与接枝氨基有机硅相比,此类末端氨基有机硅可提供改善的降低摩擦。
可用于本文的氨基有机硅的另一个示例包括例如以商品名KF8020够自Shinetsu的季铵化氨基有机硅。
当将上述氨基有机硅掺入到毛发护理组合物中时,氨基有机硅可与具有较低粘度的溶剂混合。例如,此类溶剂包括极性或非极性的、挥发性或非挥发性的油。例如,此类油包括硅油、烃和酯。在此类多种溶剂中,示例性溶剂包括选自以下的那些:非极性挥发性烃、挥发性环状有机硅、非挥发性直链有机硅、以及它们的混合物。可用于本文的非挥发性直链有机硅是25℃下粘度为约1mm2s-1至约20,000mm2s-1,诸如约20mm2s-1至约10,000mm2s-1的那些。为了降低氨基有机硅的粘度并提供改善的毛发调理有益效果(诸如减少干发上的摩擦),溶剂可为非极性挥发性烃,尤其是非极性挥发性异链烷烃。此类混合物可具有约1,000mPa.s至约100,000mPa.s,以及另选地约5,000mPa.s至约50,000mPa.s的粘度。
d.有机硅共聚物乳液
毛发护理组合物可包含内相粘度大于约100×106mm2s-1的有机硅共聚物乳液。为了提供清洁感,有机硅共聚物乳液可按组合物的重量计约0.1重量%至约15重量%,另选地约0.3重量%约10重量%,以及另选地约0.5重量%至约5重量%的量存在。
有机硅共聚物乳液在25℃下可具有大于约100×106mm2s-1,另选地大于约120×106mm2s-1,以及另选地大于约150×106mm2s-1的粘度。另选地,有机硅共聚物乳液在25℃下具有小于约1000×106mm2s-1,另选地小于约500×106mm2s-1,以及另选地小于约300×106mm2s-1的粘度。为测量有机硅共聚物乳液的内相粘度,可首先打破聚合物乳液状态。以举例的方式,以下程序可用于将聚合物从乳液中分离:1)向15毫升异丙醇中添加10克乳液样本;2)用刮刀混匀;3)滗析出异丙醇;4)添加10毫升丙酮并且用刮刀揉捏聚合物;5)滗析出丙酮;6)将聚合物置于铝容器中并且用纸巾压平/干燥;以及7)在80℃下干燥两小时。然后使用任何已知的流变仪如例如以动态剪切模式运作的CarriMed、Haake或Monsanto流变仪测试所述聚合物。通过记录在9.900*10-3Hz频点处的动态粘度(n'),可获得内相粘度值。乳液的平均粒度可小于约1微米,诸如小于约0.7微米。
本发明的有机硅共聚物乳液可包含有机硅共聚物、至少一种表面活性剂、和水。
有机硅共聚物得自以下两种物质在含金属催化剂存在下的加成反应:
(i)在两个末端上具有反应性基团的聚硅氧烷,由通式(IV)表示:
其中:
R4是能够通过链加成反应反应的基团,诸如例如氢原子、具有烯属不饱和度的脂族基团(即,乙烯基、烯丙基或己烯基)、羟基基团、烷氧基基团(即,甲氧基、乙氧基或丙氧基)、乙酰氧基基团、或氨基或烷氨基基团;
R5为烷基、环烷基、芳基、或烷基芳基,并且可包括额外的官能团如醚、羟基、胺、羧基、硫醇酯以及磺酸酯;并且R5可为甲基。任选地,小摩尔百分比的基团可为如上文R5中所述的反应基团,以产生基本上为直链但具有少量支链的聚合物。在这种情况下,与R4基团相当的R5基团的水平以摩尔百分比计可小于约10%,诸如小于约2%;s为具有一定值的整数,使得具有式(IV)的聚硅氧烷具有约1mm2s-1至约1x 106mm2s-1的粘度;
以及
(ii)至少一种有机硅化合物或非有机硅化合物,该化合物包含至少一个或最多两个能够与式(IV)中聚硅氧烷的R4基团反应的基团。反应性基团可为具有烯属不饱和度的脂族基团。
用于上述反应中的含金属催化剂通常专一于特定的反应。此类催化剂是本领域已知的。一般来讲,它们是包含金属诸如铂、铑、锡、钛、铜、铅等的物质。
用于形成乳液的混合物还可包含至少一种表面活性剂。这可包括非离子表面活性剂、阳离子表面活性剂、阴离子表面活性剂、烷基多糖、两性表面活性剂等等。上述表面活性剂可单独使用或组合使用。
制备本文所述有机硅共聚物乳液的示例性方法包括以下步骤:1)将上述物质(a)与上述物质(b)混合,随后混入适宜的含金属催化剂,使得物质(b)能够在含金属催化剂的存在下与物质(a)反应;2)进一步混入至少一种表面活性剂和水;以及3)乳化所述混合物。制备此类有机硅共聚物乳液的方法公开于美国专利6,013,682;PCT申请WO 01/58986A1;和欧洲专利申请EP0874017 A2中。
可商购获得的有机硅共混物乳液的示例为约60-70重量%的二乙烯基聚二甲硅氧烷/聚二甲基硅氧烷共聚物的乳液,所述乳液具有最小120x106mm2s-1的内相粘度,以商品名HMW2220够自Dow Corning。
e.包含季铵基团的有机硅聚合物
毛发护理组合物可包含有机硅聚合物,所述有机硅聚合物包含季铵基团(即季铵化有机硅聚合物)。季铵化的有机硅聚合物提供改善的调理有益效果,诸如光滑感、摩擦减小、防止毛发受损。该季铵基团尤其可具有对受损的/着色的毛发的良好的亲和性。季铵化有机硅聚合物以基于所述毛发调理组合物的总重量计约0.1重量%至约15重量%的量存在。例如,季铵化有机硅聚合物可以按组合物的重量计约0.2重量%至约10重量%,另选地约0.3重量%至约5重量%,以及另选地约0.5重量%至约4重量%的量存在。
本发明的季铵化有机硅聚合物由至少一种有机硅嵌段和至少一种包含季氮基团的非有机硅嵌段构成,其中非有机硅嵌段的数目比有机硅嵌段的数目多一个。所述有机硅聚合物对应于通式结构(V):
A1-B-(A2-B)m-A1 (V)
其中B为具有大于200个硅氧烷单元的有机硅嵌段;A1为可包含季铵基团的端基;A2为包含季氮基团的非有机硅嵌段;并且m为整数0或更大,条件是如果m=0,则A1基团包含季铵基团。
例如,符合通式的结构公开于美国专利4,833,225、美国专利申请公布2004/0138400、美国专利申请公布2004/0048996和美国专利申请公布2008/0292575中。
有机硅聚合物可以由以下结构(VI)表示
其中A是包含至少一个季氮基团并且通过硅-碳键连接到所述有机硅嵌段的硅原子上的基团,每个A可独立地相同或不同;R6是约1至约22个碳原子的烷基基团或者芳基基团;每个R6可独立地相同或不同;t是值为0或更大的整数,例如t可小于20,或小于10;并且u为大于约200,如大于约250,或大于约300的整数,并且u可小于约700,或小于约500。R6可为甲基。
f.接枝有机硅共聚多元醇
毛发护理组合物可包含接枝有机硅共聚多元醇与季铵化有机硅聚合物的组合。据信,该接枝有机硅共聚多元醇可通过降低季铵化有机硅聚合物的粘度来改善季铵化有机硅聚合物的铺展性,并且还可稳定含水调理剂基质中的季铵化有机硅聚合物。还据信,通过此类改善的铺展性,本发明的毛发护理组合物可提供更好的干调理有益效果诸如减小摩擦和/或防止损伤,同时降低发粘感。已令人惊奇地发现,与类似的组合相比,季铵化有机硅聚合物、接枝有机硅共聚多元醇、和阳离子表面活性剂体系(包含二烷基季铵化的铵盐阳离子表面活性剂)的组合提供改善的摩擦减小有益效果。此类类似的组合为例如其中用封端的有机硅共聚多元醇替换接枝有机硅共聚多元醇的一个组合,以及其中阳离子表面活性剂体系基本上不含二烷基季铵化的铵盐阳离子表面活性剂的另一个组合。
所述接枝有机硅共聚多元醇以一定水平被包含所述组合物中,使得在其与季铵化有机硅共聚物的混合物中,接枝有机硅共聚多元醇的重量百分比在约1重量%至约50重量%,另选地约5重量%至约40重量%,以及另选地约10重量%至30重量%的范围内。
可用于本文的接枝有机硅共聚多元醇是具有有机硅主链(诸如聚二甲基硅氧烷主链)和聚氧化亚烷基取代基(诸如聚氧化亚乙基和/或聚氧化亚丙基取代基)的那些。可用于本文的接枝有机硅共聚多元醇具有约5至约17,诸如约8至约17,或约8至约12的亲水-亲脂平衡(HLB)值。取决于有机硅部分的分子量和聚氧化亚乙基和/或聚氧化亚丙基取代基的数目,具有相同INCI名称的接枝有机硅共聚多元醇具有多种重量比。
合适的可商购获得的接枝聚二甲基硅氧烷共聚多元醇包括例如:以商品名Silsoft 430购自GE的具有约9至约12的HLB值的那些(INCI名称“PEG/PPG-20/23聚二甲基硅氧烷”);具有商品名Silsoft 475的具有约13至约17的HLB值的那些(INCI名称“PEG-23/PPG-6聚二甲基硅氧烷”);具有商品名Silsoft 880的具有约13至约17的HLB值的那些(INCI名称“PEG-12聚二甲基硅氧烷”);具有商品名Silsoft 440的具有约9至约12的HLB值的那些(INCI名称“PEG-20/PPG-23聚二甲基硅氧烷”);以商品名DC5330购自Dow Corning的那些(INCI名称“PEG-15/PPG-15聚二甲基硅氧烷”)。
在将上文季铵化有机硅聚合物和接枝有机硅共聚多元醇掺入如下所述的由阳离子表面活性剂和高熔点脂肪族化合物形成的凝胶基质之前,可将它们混合并且通过乳化表面活性剂乳化。据信该预混物可改善季铵化有机硅聚合物和接枝有机硅共聚多元醇的性能,例如增加稳定性并且降低粘度以与其它组分一起形成更均匀的制剂。此类乳化表面活性剂可以基于所述毛发调理组合物的总重量计约0.001重量%至约1.5重量%,另选地约0.005%至约1.0%,以及另选地约0.01重量%至约0.5重量%的水平使用。此类表面活性剂可为非离子的,并且具有约2至约15,诸如约3至约14,或约3至约10的HLB值。乳化表面活性剂的可商购获得的示例包括以商品名NIKKOL BT-3由NIKKO Chemicals Co.,Ltd.提供的具有INCI名称C12-C14 Pareth-3并且具有约8的HLB值的非离子表面活性剂。
毛发护理组合物可包含两种或更多种有机硅调理剂的组合连同EDDS多价螯合剂和凝胶基质。
毛发护理组合物可包含聚烷基硅氧烷混合物,所述聚烷基硅氧烷混合物包含(i)第一聚烷基硅氧烷,所述第一聚烷基硅氧烷是非挥发性的,基本上不含氨基基团,并且具有约100,000mm2s-1至约30,000,000mm2s-1的粘度,和(ii)第二聚烷基硅氧烷,所述第二聚烷基硅氧烷是非挥发性的,基本上不含氨基基团,并且具有约5mm2s-1至约10,000mm2s-1的粘度;氨基有机硅,所述氨基有机硅具有按所述氨基有机硅的重量计小于约0.5重量%的氮;以及有机硅共聚物乳液,所述有机硅共聚物乳液具有如在25℃下测量的大于约100×106mm2s-1的内相粘度。例如,毛发护理组合物可包含约0.5重量%至约10重量%的聚烷基硅氧烷混合物,所述聚烷基硅氧烷混合物包含(i)第一聚烷基硅氧烷,所述第一聚烷基硅氧烷是非挥发性的,基本上不含氨基基团,并且具有约100,000mm2s-1至约30,000,000mm2s-1的粘度,和(ii)第二聚烷基硅氧烷,所述第二聚烷基硅氧烷是非挥发性的,基本上不含氨基基团,并且具有约5mm2s-1至约10,000mm2s-1的粘度;约0.1重量%至约5重量%的氨基有机硅,所述氨基有机硅具有按所述氨基有机硅的重量计约0.5重量%的氮;以及约0.1重量%至约5重量%的有机硅共聚物乳液,所述乳液具有如在25℃下测量的大于约100x106mm2s-1的内相粘度。
毛发护理组合物可包含含季铵基团的有机硅聚合物,其中所述有机硅聚合物包含具有大于约200个硅氧烷单元的有机硅嵌段;和接枝有机硅共聚多元醇。例如,毛发护理组合物可包含约0.1重量%至约15重量%的含季铵基团的有机硅聚合物,其中所述有机硅聚合物包含具有大于约200个硅氧烷单元的有机硅嵌段;和一定量的接枝有机硅共聚多元醇,所述量使得在其与所述季铵化有机硅聚合物的混合物中,接枝有机硅共聚多元醇的重量百分比在约1重量%至约50重量%的范围内。
毛发护理组合物可包含氨基有机硅,所述氨基有机硅具有约1,000厘沲至约1,000,000厘沲的粘度,和按所述氨基有机硅的重量计小于约0.5%的氮;和(2)有机硅共聚物乳液,所述乳液具有如在25℃下测量的大于约120×106厘沲的内相粘度。
2.其它调理剂
还适用于本文毛发护理组合物中的是由Procter&Gamble公司在美国专利5,674,478和5,750,122中所描述的调理剂。还适用于本文的是美国专利4,529,586、4,507,280、4,663,158、4,197,865、4,217,914、4,381,919、和4,422,853中描述的那些调理剂。
a.有机调理油
毛发护理组合物还可进一步包含有机调理油。毛发护理组合物可包含约0.05重量%至约3重量%,约0.08重量%至约1.5重量%,或甚至约0.1重量%至约1重量%的至少一种有机调理油作为调理剂,与其它调理剂诸如有机硅(本文所述)组合。适用的调理油包括烃油、聚烯烃和脂肪酸酯。合适的烃油包括但不限于具有至少约10个碳原子的烃油,诸如环状烃、直链脂族烃(饱和或不饱和的)、和支链脂族烃(饱和或不饱和的),包括它们的聚合物以及混合物。直链烃油通常为约C12至约C19。支链烃油(包括烃聚合物)典型地将含有多于19个碳原子。合适的聚烯烃包括液体聚烯烃、液体聚α-烯烃、或甚至氢化液体聚α-烯烃。用于本文的聚烯烃可通过C4至约C14或甚至C6至约C12的聚合制备。合适的脂肪酸酯包括但不限于具有至少10个碳原子的脂肪酸酯。这些脂肪酸酯包括具有衍生自脂肪酸或脂肪醇的烃基链的酯(例如单酯、多元醇酯以及二羧酸酯和三羧酸酯)脂肪酸酯的烃基基团可包括或具有与其共价键合的其他相容官能团,诸如酰胺和烷氧基部分(例如乙氧基或醚键等)。
3.非离子聚合物
毛发护理组合物还可进一步包含非离子聚合物。用于本发明的毛发护理组合物中的调理剂可包含聚亚烷基二醇聚合物。例如,具有大于约1000的分子量的聚亚烷基二醇可用于本文。可用的是具有以下通式(VIII)的那些:
其中R11选自H、甲基、以及它们的混合物;并且v为乙氧基单元数。聚亚烷基二醇如聚乙二醇可以约0.001重量%至约10重量%的水平被包含在本发明的毛发护理组合物中。聚乙二醇可以基于组合物的重量计至多约5重量%的量存在。可用于本文的聚乙二醇聚合物是PEG-2M(还被称为PolyoxN-10,购自Union Carbide,并且被称为PEG-2,000);PEG-5M(还被称为PolyoxN-35和PolyoxN-80,购自Union Carbide,并且被称为PEG-5,000和聚乙二醇300,000);PEG-7M(还称为PolyoxN-750,购自UnionCarbide);PEG-9M(还称为PolyoxN-3333,购自Union Carbide);和PEG-14M(还被称为PolyoxN-3000,购自Union Carbide)。
4.悬浮剂
毛发护理组合物还可包含处于以下浓度的悬浮剂,所述浓度有效地将水不溶性物质以分散形式悬浮于组合物中,或有效地调节组合物的粘度。此类浓度在约0.1重量%至约10重量%,或甚至约0.3重量%至约5.0重量%的范围内。
可用于本文的悬浮剂包括阴离子聚合物和非离子聚合物。可用于本发明的是乙烯基聚合物,例如CTFA名为卡波姆的交联丙烯酸聚合物;纤维素衍生物和改性纤维素聚合物,例如甲基纤维素、乙基纤维素、羟乙基纤维素、羟丙基甲基纤维素、硝基纤维素、纤维素硫酸钠、羧甲基纤维素钠、结晶纤维素、纤维素粉末、聚乙烯吡咯烷酮、聚乙烯醇、瓜尔胶、羟丙基瓜尔胶、黄原胶、阿拉伯胶、黄蓍胶、半乳聚糖、长豆角胶、瓜尔胶、刺梧桐树胶、角叉菜胶、果胶、琼脂、温柏树籽(榅桲子)、淀粉(大米、玉米、马铃薯、小麦)、海藻胶(藻类提取物);微生物聚合物,例如葡聚糖、琥珀酰葡聚糖、普鲁兰;基于淀粉的聚合物,如羧甲基淀粉、甲基羟丙基淀粉;基于藻酸的聚合物,例如藻酸钠、褐藻酸丙二醇酯;丙烯酸酯聚合物,例如聚丙烯酸钠、聚丙烯酸乙酯、聚丙烯酰胺、聚乙烯亚胺;以及无机水溶性物质,例如膨润土、硅酸铝镁盐、合成锂皂石、锂蒙脱石和无水硅酸。
高度可用于本文的可商购获得的粘度调节剂包括卡波姆,其具有商品名934、940、950、980和981,全部均购自B.F.Goodrich公司,丙烯酸酯/硬脂基聚氧乙烯醚-20甲基丙烯酸酯共聚物,其以商品名ACRYSOLTM 22购自Rohm and Hass,壬苯醇醚羟乙基纤维素,其以商品名AmercellTMPOLYMER HM-1500购自Amerchol,甲基纤维素,其具有商品名羟乙基纤维素,其具有商品名羟丙基纤维素,其具有商品名十六烷基羟乙基纤维素,其具有商品名67,全部均由Hercules提供,基于环氧乙烷和/或环氧丙烷的聚合物,其具有商品名PEGs、POLYOX WASRs、以及FLUIDS,全部均由Amerchol提供。
其它任选的悬浮剂包括结晶的悬浮剂,它可被分类为酰基衍生物、长链胺氧化物、以及它们的混合物。这些悬浮剂描述于美国专利4,741,855中。
这些悬浮剂包括在一个方面具有约16至约22个碳原子的脂肪酸的乙二醇酯。在一个方面,可用的悬浮剂包括硬脂酸乙二醇酯,一硬脂酸酯和二硬脂酸酯两者,但在一个方面,二硬脂酸酯包含小于约7%的一硬脂酸酯。其它合适的悬浮剂包括具有约16至约22个碳原子,或甚至约16至18个碳原子的脂肪酸的烷醇酰胺,其示例包括硬脂酰一乙醇酰胺、硬脂酰二乙醇酰胺、硬脂酰一异丙醇酰胺和硬脂酰一乙醇酰胺硬脂酸酯。其它长链酰基衍生物包括长链脂肪酸的长链酯(例如硬脂酸十八烷基酯、棕榈酸鲸蜡酯等);长链烷醇酰胺的长链酯(例如硬脂酰胺二乙醇酰胺二硬脂酸酯、硬脂酰胺单乙醇酰胺硬脂酸酯);和甘油酯(如甘油二硬脂酸酯、三羟基硬脂酸甘油酯、三山嵛酸甘油酯),其商业示例为购自Rheox,Inc.的Thixin R;长链酰基衍生物,长链羧酸的乙二醇酯、长链氧化胺、和长链羧酸的烷醇酰胺。
适用作悬浮剂的其它长链酰基衍生物包括N,N-二烃基酰胺基苯甲酸及其可溶性盐(例如Na、K),尤其是该类中的N,N-二(氢化)C16、C18和牛脂酰胺基苯甲酸类,其可从Stepan Company(Northfield,Ill.,USA)商购获得。
用作悬浮剂的合适的长链氧化胺的示例包括烷基二甲基氧化胺,例如硬脂基二甲基氧化胺。
其它合适的悬浮剂包括具有含至少约16个碳原子的脂肪烷基部分的伯胺(其示例包括棕榈胺或十八胺)和具有两个各含至少约12个碳原子的脂肪烷基部分的仲胺(其示例包括二棕榈酰基胺或二(氢化牛脂)胺)。其它合适的悬浮剂包括二(氢化牛脂)邻苯二甲酸酰胺和交联的马来酸酐-甲基乙烯基醚共聚物。
H.有益剂
毛发护理组合物还可包含一种或多种附加有益剂。有益剂包括选自以下的材料:去头皮屑剂、维生素、脂溶性维生素、螯合剂、香料、增白剂、酶、感觉剂、诱虫剂、抗菌剂、染料、颜料、漂白剂、以及它们的混合物。
在一个方面,所述有益剂可包括去头皮屑剂。此类去头皮屑微粒应该在物理和化学上与组合物的组分相容,并且不应该不适当地以其他方式破坏产品的稳定性、美观性或性能。
毛发护理组合物可包含去头皮屑活性物质,其可为去头皮屑活性物质微粒。去头皮屑活性物质可选自由以下组成的组:吡啶硫酮盐;唑类,诸如酮康唑、益康唑和新康唑;硫化硒;微粒硫;角质层分离剂,诸如水杨酸;以及它们的混合物。去头皮屑微粒可为吡啶硫酮盐。
吡啶硫酮微粒是合适的微粒去头皮屑活性物质。去头皮屑活性物质可为1-羟基-2-吡啶硫酮盐,并且为微粒形式。吡啶硫酮去头皮屑微粒的浓度在约0.01重量%至约5重量%,或约0.1重量%至约3重量%,或约0.1重量%至约2重量%的范围内。吡啶硫酮盐是由重金属诸如锌、锡、镉、镁、铝和锆(通常为锌)形成的那些,通常为1-羟基-2-吡啶硫酮的锌盐(称为“吡啶硫酮锌”或“ZPT”),通常为片状颗粒形式的1-羟基-2-吡啶硫酮盐。可为片状颗粒形式的1-羟基-2-吡啶硫酮盐具有至多约20微米、或至多约5微米、或至多约2.5微米的平均粒度。由其它阳离子诸如钠形成的盐也可为合适的。吡啶硫酮去头皮屑活性物质描述于例如美国专利2,809,971;美国专利3,236,733;美国专利3,753,196;美国专利3,761,418;美国专利4,345,080;美国专利4,323,683;美国专利4,379,753;和美国专利4,470,982中。
除了选自吡啶硫酮的多价金属盐的去头皮屑活性物质以外,该组合物还可包含一种或多种抗真菌活性物质和/或抗微生物活性物质。抗微生物活性物质可选自由以下组成的组:煤焦油、硫、木炭、复方苯甲酸软膏、卡斯太拉尼氏涂剂、氯化铝、龙胆紫、羟甲辛吡酮(吡罗克酮乙醇胺盐)、环吡酮胺、十一碳烯酸及其金属盐、高锰酸钾、硫化硒、硫代硫酸钠、丙二醇、苦橙油、尿素制剂、灰黄霉素、8-羟基喹啉氯碘羟喹、硫代地巴唑、硫代氨基甲酸酯、卤普罗近、聚烯、羟基吡啶酮、吗啉、苄胺、烯丙胺(诸如特比萘芬)、茶树油、丁香叶油、芫荽、玫瑰草、小檗碱、百里香红、桂皮油、肉桂醛、香茅酸、扁柏酚、页岩油、Sensiva SC-50、Elestab HP-100、壬二酸、溶细胞酶、碘代丙炔基丁基氨基甲酸酯(IPBC)、异噻唑啉酮诸如辛基异噻唑啉酮和唑类、以及它们的混合物。抗微生物剂可选自由以下组成的组:伊曲康唑、酮康唑、硫化硒、煤焦油、以及它们的混合物。
唑类抗微生物剂可为选自由以下组成的组的咪唑:苯并咪唑、苯并噻唑、联苯苄唑、丁康唑硝酸盐、氯咪巴唑、克霉唑、克鲁康唑、依柏康唑、益康唑、新康唑、芬替康唑、氟康唑、氟三唑、异康唑、酮康唑、兰诺康唑、甲硝唑、咪康唑、奈康唑、奥莫康唑、奥昔康唑硝酸盐、舍他康唑、硝酸硫康唑、噻康唑、噻唑、以及它们的混合物,或者所述唑类抗微生物剂为选自由以下组成的组的三唑:特康唑、伊曲康唑、以及它们的混合物。当存在于毛发护理组合物中时,唑类抗微生物活性物质的含量可为约0.01重量%至约5重量%,或约0.1重量%至约3重量%,或约0.3重量%至约2重量%。唑类抗微生物活性物质可为酮康唑。唯一的抗微生物活性物质可为酮康唑。
毛发护理组合物的实施方案还可包含抗微生物活性物质的组合。抗微生物活性物质的组合可选自由以下组成的组合:羟甲辛吡酮和吡啶硫酮锌、松焦油和硫、水杨酸和吡啶硫酮锌、水杨酸和新康唑、吡啶硫酮锌和新康唑、吡啶硫酮锌和氯咪巴唑、羟甲辛吡酮和氯咪巴唑、水杨酸和羟甲辛吡酮、以及它们的混合物。
毛发护理组合物可包含有效量的含锌层状物质。毛发护理组合物可包含按毛发护理组合物的总重量计约0.001重量%至约10重量%、或约0.01重量%至约7重量%、或约0.1重量%至约5重量%的含锌层状物质。
含锌层状物质可为主要在二维平面上具有晶体生长的那些。常规上将层状结构描述为不仅其中所有原子均掺入良好限定的层中的那些,而且其中在层之间存在称为隧道离子(A.F.Wells,“Structural Inorganic Chemistry”Clarendon Press,1975)的离子或分子的那些。含锌层状物质(ZLM)可具有掺入层中的锌和/或可作为隧道离子的组分。以下类别的ZLM代表了总类别中相对常见的示例,并且不旨在对范围更广的符合此定义的材料作出限制。
许多ZLM在自然界以矿物的形式出现。ZLM可选自由以下组成的组:水锌矿(碳酸锌氢氧化物)、绿铜锌矿(碳酸锌铜氢氧化物)、斜方绿铜锌矿(碳酸铜锌氢氧化物)、以及它们的混合物。相关的含锌矿物质也可被包含组合物中。天然ZLM也可存在,其中阴离子层物质诸如粘土型矿物质(例如页硅酸盐)含有离子交换的锌隧道离子。所有这些天然物质也可通过合成获得,或在组合物中或在生产过程期间原位形成。
另一种通常但不总是合成获得的常见类别ZLM为层状二元氢氧化物。ZLM可为符合式[M2+ 1-xM3+ x(OH)2]x+Am- x/m·nH2O的层状二元氢氧化物,其中一些或所有的二价离子(M2+)为锌离子(Crepaldi,EL,Pava,PC,Tronto,J,Valim,JB J.Colloid Interfac.Sci.2002,248,429-42)。
可制备另一类别的ZLM,称为羟基复盐(Morioka,H.,Tagaya,H.,Karasu,M,Kadokawa,J,Chiba,K Inorg.Chem.1999,38,4211-6)。ZLM可为符合式[M2+ 1-xM2+ 1+x(OH)3(1-y)]+An- (1=3y)/n·nH2O的羟基复盐,其中两个金属离子(M2+)可以相同或不同。如果它们相同并且由锌表示,则该式简化为[Zn1+x(OH)2]2x+2x A-·nH2O。后一式代表了(其中x=0.4)材料诸如羟基氯化锌和碱式硝酸锌。ZLM可为羟基氯化锌和/或羟基硝酸锌。这些也涉及水锌矿,其中二价阴离子置换了一价阴离子。这些材料还可在组合物中或在生产过程中或生产过程期间原位形成。
在含有含锌层状物质和吡啶硫酮或吡啶硫酮的多价金属盐的产品中,含锌层状物质与吡啶硫酮或吡啶硫酮的多价金属盐之比为约5:100至约10:1、或约2:10至约5:1、或约1:2至约3:1。
去头皮屑活性物质的头皮上沉积物为至少约1μg/cm2。为确保去头皮屑活性物质到达它能够执行其功能的头皮,去头皮屑活性物质的头皮上沉积物是重要的。去头皮屑活性物质在头皮上的沉积物可为至少约1.5μg/cm2,或至少约2.5μg/cm2,或至少约3μg/cm2,或至少约4μg/cm2,或至少约6μg/cm2,或至少约7μg/cm2,或至少约8μg/cm2,或至少约8μg/cm2,或至少约10μg/cm2。根据常规洗涤方案,由专业美容师用包含去头皮屑活性物质的组合物例如根据本发明的组合物洗涤个体毛发,来测量去头皮屑活性物质的头皮上沉积。然后头皮区域上的毛发分开,以允许末端开放的玻璃量筒能够保留在表面上,同时添加提取溶液的等分试样,并且搅拌,然后回收,并且由常规方法诸如HPLC分析测定去头皮屑活性物质含量。
产品形式
本发明的组合物可为洗去型产品形式或免洗型产品形式,并且可被配制成多种产品形式,包括但不限于霜膏、凝胶、乳液、摩丝和喷剂。本发明的组合物尤其适用于调理组合物,尤其是免洗型(leave-on)、免洗型(leave-in)和/或无冲洗(no-rinse)组合物。免洗型(leave-on)和免洗型(leave-in)调理组合物通常用于干发、半湿发和/或湿发,而无需冲洗掉组合物。通过无冲洗组合物,本文中意味着在洗发后在半湿至湿发上使用的毛发护理组合物,而无需冲洗掉无冲洗毛发护理组合物(如无冲洗毛发调理剂)。
测试方法
疲劳测量
使用Dia-stron自动组件系统(AAS 1600),自发束的中间切割纤维以用于疲劳强度测量并且将端部卷曲在30mm处。使用结合Mitutoyo激光器测微器(LSM-6200)的Dia-Stron纤维尺寸分析系统(FDAS 770)来分析沿每个纤维的平均横截面积。由沿每个30mm卷曲纤维的三个直径测量点来计算平均横截面积。
对于疲劳强度,然后使用每个纤维的平均横截面值来将Dia-Stron循环测试仪(CYC801)设定在0.014g/μm2的受控应力模式和40mm/s的速率下。相对湿度设定为50%RH并且温度设定为23℃。由Weibull和Kaplan-Meier统计工具(JMP Pro 12.1.0,SAS Cary,NC)来分析数据。分析中省略了破损周期小于十的纤维(归因于过早破损)。测量了100个纤维每小组。
样品制备
通过将壬二酸和/或油酸以0.0833%的总酸溶解在水/乙醇中,并且用NaOH溶液将pH调节至大约4.5来制备样品溶液。将这些溶液注射到4g/8”常规漂白(IHI来源的)毛发样本(6mL)上,并且在环境室内条件下保持渗透/干燥。这产生用1.25mg总酸/g毛发投配的毛发。
实施例
以下实施例进一步描述并展示了本发明范围内的实施方案。这些实施例仅为了例证目的而给出并且不可被理解为是对本发明的限制,因为在不脱离本发明的实质和范围的情况下可能有许多变型。此处适用的成分均以化学名或CTFA名来识别,除非下文另外限定。
光滑洗去型调理剂组合物
1.末端氨基封端的聚二甲基硅氧烷(其粘度为10,000cP,在25℃下)可购自Momentive Performance Materials。
2.Kathon CG,购自Dow(1.5重量%活性物质)
丰盈洗去型调理剂组合物
1.Jaguar HP-105,由Rhodia供应
2.二牛脂二甲基氯化铵
3.末端氨基封端的聚二甲基硅氧烷(其粘度为10,000cP,在25℃下)可购自Momentive Performance Materials。
4.Kathon CG,可购自Dow(1.5重量%活性物质)。
毛发修复洗去型调理剂组合物
1.硅橡胶纯胶料和硅油的混合物XF49-B1747,可购自Momentive PerformanceMaterials。
2.Kathon CG,可购自Dow(1.5重量%活性物质)。
免洗型处理组合物
1.Siameter MEM-0949乳液,可购自Dow Corning;它包含35%氨基有机硅
2.乙烯基吡咯烷酮和季铵化的甲基丙烯酸二甲氨基乙酯的共聚物;Gafquat755NH,可购自Ashland
组分 | 活性物质% | 重量% |
羟乙基纤维素<sup>1</sup> | 80 | 0.400 |
鲸蜡醇<sup>2</sup> | 90 | 0.575 |
硬脂醇<sup>3</sup> | 97 | 0.383 |
苄醇<sup>4</sup> | 99 | 0.400 |
乙二胺四乙酸二钠二水合物<sup>5</sup> | 99 | 0.127 |
单硬脂酸甘油酯(PoloxWSR N-10)<sup>6</sup> | 1.5 | 0.299 |
末端氨基有机硅<sup>7</sup> | 90-100 | 2 |
香料 | 0.550 | |
油酸 | 100 | 1.50 |
壬二酸 | 100 | 0.50 |
纯化水 | 适量 |
1.NatrosolTM羟乙基纤维素,由Ashland(Kentucky,US)供应
2.由P&G Chemicals供应
3.由P&G Chemicals供应
4.由Ineos Maastricht BV(Maastricht NL)供应
5.Trilon BD粉末,由BASF SE(Ludwigshafen,DE)供应
6.POLYOXTM WSR N-10(单硬脂酸甘油酯),由Dow chemicals(Michigan US)供应
7.Y-14945,由Momentive Performance Materials供应
本文所公开的量纲和值不应理解为严格限于所引用的精确数值。相反,除非另外指明,否则每个此类量纲旨在表示所述值以及围绕该值功能上等同的范围。例如,公开为“40mm”的量纲旨在表示“约40mm”。
除非明确排除或以其它方式限制,本文中引用的每一篇文献,包括任何交叉引用或相关专利或专利申请以及本申请对其要求优先权或其有益效果的任何专利申请或专利,均据此全文以引用方式并入本文。对任何文献的引用不是对其作为与本发明的任何所公开或本文受权利要求书保护的现有技术的认可,或不是对其自身或与任何一个或多个参考文献的组合提出、建议或公开任何此类发明的认可。此外,当本发明中术语的任何含义或定义与以引用方式并入的文献中相同术语的任何含义或定义矛盾时,应当服从在本发明中赋予该术语的含义或定义。
虽然已举例说明和描述了本发明的具体实施方案,但是对于本领域技术人员来说显而易见的是,在不脱离本发明的实质和范围的情况下可作出各种其他变化和修改。因此,本文旨在于所附权利要求中涵盖属于本发明范围内的所有此类变化和修改。
Claims (13)
1.一种毛发护理组合物,包含:
约0.04重量%至约2重量%的壬二酸;
约0.04重量%至约1重量%的油酸;
其中油酸与壬二酸之比为约1:1至约1:3的油酸:壬二酸;
以及含水载体。
2.根据任一前述权利要求所述的毛发护理组合物,其中所述油酸与壬二酸之比为约1:2.5至约1:3,优选地其中所述油酸与壬二酸之比为约1:2至约1:3,优选地其中所述油酸与壬二酸之比为约1:1.5至约1:3。
3.根据任一前述权利要求所述的毛发护理组合物,其中所述组合物包含约0.1重量%至约1重量%的壬二酸,并且其中所述组合物包含约0.1重量%至约0.5重量%的油酸。
4.根据任一前述权利要求所述的毛发护理组合物,还包含高熔点脂肪族化合物,优选地其中所述高熔点脂肪族化合物选自由以下组成的组:鲸蜡醇、硬脂醇、山嵛醇、以及它们的混合物。
5.根据任一前述权利要求所述的毛发护理组合物,其中所述一种或多种高熔点脂肪族化合物可以约0.1重量%至约20重量%的水平被包含在所述毛发护理组合物中,优选地其中所述一种或多种高熔点脂肪族化合物可以约1%至约15%的水平被包含在所述毛发护理组合物中。
6.根据任一前述权利要求所述的毛发护理组合物,还包含有机硅化合物,优选地其中所述有机硅化合物选自由以下组成的组:聚二甲基硅氧烷有机硅、有机硅季铵盐-26、末端氨基有机硅、以及它们的组合。
7.根据任一前述权利要求所述的毛发护理组合物,其中所述毛发护理组合物为毛发调理剂。
8.根据任一前述权利要求所述的毛发护理组合物,其中所述毛发护理组合物为免洗型处理物。
9.根据任一前述权利要求所述的毛发护理组合物,其中所述毛发护理组合物为洗去型调理剂。
10.根据任一前述权利要求所述的毛发护理组合物,还包含阳离子表面活性剂体系。
11.根据任一前述权利要求所述的毛发护理组合物,其中所述阳离子表面活性剂体系可选自由以下组成的组:单长链烷基季铵化铵盐;单长链烷基季铵化铵盐和二长链烷基季铵化铵盐的组合;单长链烷基酰胺基胺盐;单长链烷基酰胺基胺盐和二长链烷基季铵化铵盐的组合,单长链烷基酰胺基胺盐、单长链烷基季铵化铵盐的组合,以及它们的组合。
12.根据任一前述权利要求所述的毛发护理组合物,其中所述组合物包含约0.1重量%至约10重量%的阳离子表面活性剂体系。
13.根据任一前述权利要求所述的毛发护理组合物,其中所述组合物包含凝胶基质。
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PCT/US2020/070881 WO2021119660A1 (en) | 2019-12-10 | 2020-12-09 | Hair strengthening composition |
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US11883513B2 (en) | 2024-01-30 |
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