CN114772535B - Filling and sealing device for preparing calcium gluconate injection - Google Patents

Filling and sealing device for preparing calcium gluconate injection Download PDF

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Publication number
CN114772535B
CN114772535B CN202210616209.5A CN202210616209A CN114772535B CN 114772535 B CN114772535 B CN 114772535B CN 202210616209 A CN202210616209 A CN 202210616209A CN 114772535 B CN114772535 B CN 114772535B
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China
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filling
pressure
lifting
sealing
calcium gluconate
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CN114772535A (en
Inventor
龚文卿
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Huaxiashengsheng Pharmaceutical Beijing Co ltd
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Huaxiashengsheng Pharmaceutical Beijing Co ltd
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
    • B67C7/0006—Conveying; Synchronising
    • B67C7/0026—Conveying; Synchronising the containers travelling along a linear path
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B1/00—Closing bottles, jars or similar containers by applying stoppers
    • B67B1/04—Closing bottles, jars or similar containers by applying stoppers by inserting threadless stoppers, e.g. corks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
    • B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
    • B67C3/22—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
    • B67C7/0073—Sterilising, aseptic filling and closing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
    • B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
    • B67C3/22—Details
    • B67C2003/228—Aseptic features

Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a filling and sealing device for preparing calcium gluconate injection, which comprises an ultrahigh Wen Gui cleaning cabinet, a sterile cabinet and a sealing cabinet, wherein the cleaning cabinet is connected with one end of the ultrahigh temperature cabinet in a sealing manner; the top surface fixedly connected with two sets of risers of aseptic cabinet, the top surface of riser can be dismantled and be connected with first pneumatic cylinder, still includes: the device comprises a high-pressure driving mechanism, a filling mechanism, a sealing mechanism and an isolating mechanism; the high-pressure driving mechanism and the isolation mechanism are arranged, so that the sealing mechanism can not be polluted by external environment when the filling operation is performed, and the high-pressure driving mechanism, the filling mechanism, the sealing mechanism and the isolation mechanism are all arranged on the outer side of the sterile cabinet.

Description

Filling and sealing device for preparing calcium gluconate injection
Technical Field
The invention belongs to the technical field of medical equipment, and particularly relates to a filling and sealing device for preparing calcium gluconate injection.
Background
In the preparation process of the calcium gluconate injection, the last link is the encapsulation operation of the calcium gluconate injection, and because the calcium gluconate injection is directly injected into a human body for use, the whole process of the calcium gluconate injection needs to be carried out in a sterile environment, so that the calcium gluconate injection is ensured not to be polluted by the external environment;
the filling and sealing mechanism and the filling and sealing operation of the filling and sealing device for preparing the calcium gluconate injection are carried out in a closed sterile environment, the closed sterile environment can ensure that the calcium gluconate injection is not polluted when the filling and sealing device is used for filling and sealing the calcium gluconate injection, but when the filling and sealing device for preparing the calcium gluconate injection needs to be maintained or individual loss parts are replaced, the sterile environment is destroyed, when the calcium gluconate injection needs to be filled and sealed, the whole environment needs to be sterilized again, and as the filling and sealing production line of the calcium gluconate injection is long, the required closed sterile environment is larger, the time of sterilization is long, the cost of sterilization is high, and the maintenance cost of the filling and sealing device is increased;
therefore, a filling and sealing device for preparing the calcium gluconate injection is needed, so that the maintenance cost of the filling and sealing device is reduced while the pollution of the calcium gluconate injection in filling and sealing is avoided.
Disclosure of Invention
In order to make up the defects of the prior art, the invention provides the filling and sealing device for preparing the calcium gluconate injection, and the high-pressure driving mechanism and the isolation mechanism are arranged to ensure that the sealing mechanism cannot be polluted by external environment when filling operation is carried out.
The technical scheme adopted for solving the technical problems is as follows: the invention relates to a filling and sealing device for preparing calcium gluconate injection, which comprises an ultra-high Wen Gui, a cleaning cabinet hermetically connected with one end of an ultra-high temperature cabinet, and a sterile cabinet hermetically connected with the other end of the ultra-high temperature cabinet;
the top surface fixedly connected with two sets of risers of aseptic cabinet, the top surface of riser can be dismantled and be connected with first pneumatic cylinder, still includes:
the high-pressure driving mechanism is detachably connected with the hydraulic rod of the first hydraulic cylinder and is connected with the ultra-high temperature cabinet through a pipeline and used for absorbing high-temperature gas in the ultra-high temperature cabinet so as to generate high pressure in the high-pressure driving mechanism;
the filling mechanism is movably arranged at the bottom of the left high-pressure driving mechanism and is used for transporting the calcium gluconate injection;
the sealing mechanism is movably arranged at the bottom of the right high-pressure driving mechanism and is used for sealing the calcium gluconate injection;
the isolation mechanism is arranged at the position, close to the vertical plate, of the top surface of the sterile cabinet and is used for isolating the inner space of the sterile cabinet and matching with the high-voltage driving mechanism.
Preferably, the high-pressure driving mechanism comprises a lifting plate, the bottom end of a hydraulic rod of the first hydraulic cylinder is detachably connected with the top surface of the lifting plate, and the first hydraulic cylinder can be replaced by an electric actuating mechanism and is mainly used for adjusting the height of the lifting plate;
the side plate is fixedly arranged on the top surface of the lifting plate, the top end of the side plate is detachably connected with a second hydraulic cylinder, and the second hydraulic cylinder can be replaced by an electric actuating mechanism and is mainly used for adjusting the height of the high-pressure lifting piece;
the extrusion rods are fixedly connected with the bottom surface of the lifting plate, and the number of the extrusion rods is two or four and are used for opening the isolation mechanism and matching with the filling mechanism or the sealing mechanism;
the high-pressure lifting piece is arranged on the inner side of the side plate in a sliding manner, and a hydraulic rod of the second hydraulic cylinder is detachably connected with the high-pressure lifting piece;
the air pump, the air pump can dismantle the side that sets up at the curb plate, the air pump passes through pipe connection superhigh temperature cabinet and high pressure lifter, and the air pump also can set up the top surface, the main high-pressure state that produces in making high pressure actuating mechanism at the lifter, can reject the external gas.
Preferably, the top surface of filling mechanism is close to the through-hole that the extrusion pole was agreed with in the position penetration that the extrusion pole was agreed with, the bottom surface fixedly connected with of filling mechanism first exhaust piece for exhaust the air of isolating mechanism top surface.
Preferably, the high-pressure lifting part is a lifting filling pipe, the top surface of the filling mechanism is fixedly connected with a pipe sleeve matched with the lifting filling pipe, a first high-pressure cavity is formed in the position, close to the lifting filling pipe, of the bottom surface of the first air exhaust block, the pipe sleeve is communicated with the first high-pressure cavity, and the air pump is communicated with the first high-pressure cavity through a pipeline.
Preferably, a spring is nested at a position, close to the position between the lifting plate and the filling mechanism, of the side face of the extrusion rod, the bottom face of the extrusion rod is fixedly connected with an arc-shaped block, and the diameter of the arc-shaped block is larger than that of the through hole.
Preferably, the top surface of sealing mechanism is close to the through-hole that the extrusion pole was run through and is fit with the extrusion pole, sealing mechanism's bottom surface fixedly connected with second exhaust piece for exhaust the air of isolating mechanism top surface, sealing mechanism's front intermediate position fixedly connected with feed plate, offer the conveyer trough in the feed plate, mainly used transportation calcium gluconate injection bottle's bottle plug.
Preferably, the high-pressure lifting part is a lifting pressure rod, the top surface of the sealing mechanism is fixedly connected with a rod sleeve matched with the lifting pressure rod, a second high-pressure cavity is formed in the position, close to the lifting pressure rod, of the bottom surface of the second air exhaust block, the rod sleeve is communicated with the second high-pressure cavity, and the air pump is communicated with the second high-pressure cavity through a pipeline.
Preferably, a spring is nested at a position, close to the position between the lifting plate and the sealing mechanism, of the side face of the extrusion rod, the bottom face of the extrusion rod is fixedly connected with an arc-shaped block, and the diameter of the arc-shaped block is larger than that of the through hole.
Preferably, the inside of isolation mechanism has seted up the intercommunication groove, the intercommunication groove passes through the spring mounting and has two symmetrical isolation sliders, the extrusion groove has been seted up to isolation mechanism's top surface, and this isolation slider also can adopt electric drive, electromagnetic drive, and the main internal environment that is used for can freely opening aseptic cabinet guarantees that filling mechanism and sealing mechanism can carry out filling and sealing to the calcium gluconate injection bottle in the aseptic cabinet.
Preferably, the positions of the extrusion grooves are in one-to-one correspondence with the positions of the extrusion rods, and the positions, close to the extrusion grooves, of the two sides of the isolation sliding block are provided with inclined grooves.
The beneficial effects of the invention are as follows:
according to the invention, when the calcium gluconate injection is filled and sealed, the high-pressure driving mechanism is connected with the ultra-high temperature cabinet through the pipeline, so that high-temperature gas in the ultra-high temperature cabinet can be absorbed, the high-temperature gas can generate high pressure in the high-pressure driving mechanism, and thus external air can be repelled, the high-temperature gas in the ultra-high temperature cabinet is sterile gas, so that the filling mechanism can be prevented from being polluted by external environment when the filling operation is performed, and the sealing mechanism is arranged between the high-pressure driving mechanism and the isolating mechanism, so that the sealing mechanism can be prevented from being polluted by external environment when the filling operation is performed, and the high-pressure driving mechanism, the filling mechanism, the sealing mechanism and the isolating mechanism are all arranged outside the sterile cabinet.
Drawings
The invention will be further described with reference to the drawings and embodiments.
FIG. 1 is a perspective view of a sterile cabinet of the present invention;
FIG. 2 is a front view of the aseptic cabinet of the present invention;
FIG. 3 is a perspective view of the filling mechanism of the present invention;
FIG. 4 is a schematic view of the structure of the filling mechanism of the present invention;
FIG. 5 is a perspective view of the sealing mechanism of the present invention;
FIG. 6 is a schematic view of the seal mechanism of the present invention;
FIG. 7 is a perspective view of the isolation mechanism of the present invention;
FIG. 8 is a cross-sectional view of the isolation mechanism of the present invention;
fig. 9 is a front view of the present invention.
In the figure: 1. an aseptic cabinet; 11. a washing cabinet; 12. ultrahigh Wen Gui; 2. a conveyor belt; 3. a vertical plate; 31. a first hydraulic cylinder; 4. a high-voltage driving mechanism; 41. a lifting plate; 42. a side plate; 43. a second hydraulic cylinder; 44. an extrusion rod; 45. a high-pressure elevating member; 451. lifting the filling pipe; 452. a lifting pressure lever; 46. an air pump; 5. a filling mechanism; 51. a first air discharge block; 52. a pipe sleeve; 53. a first high pressure chamber; 6. a sealing mechanism; 61. a second air discharge block; 62. a feed plate; 63. a rod sleeve; 64. a second high pressure chamber; 7. an isolation mechanism; 71. a communication groove; 72. an isolation slider; 73. and extruding the groove.
Detailed Description
The invention is further described in connection with the following detailed description in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
Example 1:
as shown in fig. 1 to 9, the encapsulating device for preparing calcium gluconate injection comprises an ultra-high temperature cabinet 12, a cleaning cabinet 11 which is connected with one end of the ultra-high temperature cabinet 12 in a sealing way, and a sterile cabinet 1 which is connected with the other end of the ultra-high temperature cabinet 12 in a sealing way;
the top surface fixedly connected with two sets of risers 3 of aseptic cabinet 1, the top surface of riser 3 can be dismantled and be connected with first pneumatic cylinder 31, still includes:
the high-pressure driving mechanism 4 is detachably connected with a hydraulic rod of the first hydraulic cylinder 31, and the high-pressure driving mechanism 4 is connected with the ultra-high temperature cabinet 12 through a pipeline and is used for absorbing high-temperature gas in the ultra-high temperature cabinet 12 so as to generate high pressure in the high-pressure driving mechanism 4;
the filling mechanism 5 is movably arranged at the bottom of the left high-pressure driving mechanism 4 and is used for transporting calcium gluconate injection;
the sealing mechanism 6 is movably arranged at the bottom of the right high-pressure driving mechanism 4 and is used for sealing the calcium gluconate injection;
the isolation mechanism 7 is arranged on the top surface of the aseptic cabinet 1 and is close to the vertical plate 3, and the isolation mechanism 7 is used for isolating the internal space of the aseptic cabinet 1 and matching with the high-pressure driving mechanism 4;
in operation, taking 50ml of calcium gluconate injection as an example, as shown in fig. 9, a conveying belt 2 for conveying 50ml of injection bottles is arranged in a sterile cabinet 1, a cleaning cabinet 11 and an ultra-high temperature cabinet 12, firstly, 50ml of injection bottles can be placed on the conveying belt 2 corresponding to the cleaning cabinet 11, the 50ml of injection bottles can be conveyed into the ultra-high temperature cabinet 12 by the conveying belt 2, the temperature of the ultra-high temperature cabinet 12 is regulated to ensure that the temperature in the ultra-high temperature cabinet 12 is between 135 ℃ and 150 ℃, the ultra-high temperature cabinet 12 can be heated by adopting resistance, the moving speed of the conveying belt 2 is regulated, the 50ml of injection bottles can stay in the ultra-high temperature cabinet 12 for 2 to 8 seconds, and the ultra-high temperature cabinet 12 can boil water drops remained when the 50ml of injection bottles are clear, so that the effect of drying is achieved;
after sterilization by the ultra-high temperature cabinet 12, 50ml injection bottles can be continuously transported into the aseptic cabinet 1 by the conveyor belt 2, and the filling mechanism 5 arranged on the aseptic cabinet 1 can perform filling operation on the 50ml injection bottles, specifically, the calcium gluconate injection is injected into the 50ml injection bottles, as shown in fig. 3, the filling mechanism 5 is arranged between the high-pressure driving mechanism 4 and the isolation mechanism 7, the high-pressure driving mechanism 4 is connected with the ultra-high temperature cabinet 12 through a pipeline, high-temperature gas in the ultra-high temperature cabinet 12 can be absorbed, the high-temperature gas can generate high pressure in the high-pressure driving mechanism 4, so that external air can be repelled, the high-temperature gas in the ultra-high temperature cabinet 12 is aseptic gas, and therefore, the filling mechanism 5 can be ensured not to be polluted by external environment when the filling operation is performed, and also as shown in fig. 5, the sealing mechanism 6 is arranged between the high-pressure driving mechanism 4 and the isolation mechanism 7, and therefore, the sealing mechanism 6 can be ensured not to be polluted by external environment when the filling operation is performed;
as shown in fig. 1 and 2, since the high-pressure driving mechanism 4, the filling mechanism 5, the sealing mechanism 6 and the isolation mechanism 7 are all arranged outside the aseptic cabinet 1, the filling and sealing device only needs to ensure the aseptic environment in the inner cavity of the aseptic cabinet 1, and the outside of the aseptic cabinet 1 is not required, so that when the mechanism is maintained, the whole filling and sealing device and the external environment are not required to be sterilized, and the maintenance cost is low.
The high-pressure driving mechanism 4 comprises a lifting plate 41, and the bottom end of a hydraulic rod of the first hydraulic cylinder 31 is detachably connected with the top surface of the lifting plate 41;
the side plate 42 is fixedly arranged on the top surface of the lifting plate 41, and the top end of the side plate 42 is detachably connected with the second hydraulic cylinder 43;
the extrusion rod 44, the extrusion rod 44 is fixedly connected with the bottom surface of the lifting plate 41;
a high-pressure elevating member 45, wherein the high-pressure elevating member 45 is slidably disposed inside the side plate 42, and the hydraulic rod of the second hydraulic cylinder 43 is detachably connected with the high-pressure elevating member 45;
the air pump 46 is detachably arranged on the side surface of the side plate 42, and the air pump 46 is connected with the ultra-high temperature cabinet 12 and the high-pressure lifting piece 45 through a pipeline;
a through hole matched with the extrusion rod 44 is penetrated through the top surface of the filling mechanism 5 close to the extrusion rod 44, and a first air exhaust block 51 is fixedly connected with the bottom surface of the filling mechanism 5;
the high-pressure lifting part 45 is a lifting filling pipe 451, the top surface of the filling mechanism 5 is fixedly connected with a pipe sleeve 52 matched with the lifting filling pipe 451, a first high-pressure cavity 53 is formed in the bottom surface of the first air discharging block 51 near the lifting filling pipe 451, the pipe sleeve 52 is communicated with the first high-pressure cavity 53, and the air pump 46 is communicated with the first high-pressure cavity 53 through a pipeline;
a spring is nested at a position between the side surface of the extrusion rod 44, which is close to the lifting plate 41, and the filling mechanism 5, the bottom surface of the extrusion rod 44 is fixedly connected with an arc-shaped block, and the diameter of the arc-shaped block is larger than that of the through hole;
when the device works, after the filling mechanism 5 contacts the isolation mechanism 7, the lifting plate 41 further descends, the spring can be compressed, the elastic force of the spring acts on the top surface of the filling mechanism 5, the filling mechanism 5 contacts the isolation mechanism 7 more stably, the diameter of the arc-shaped block is larger than that of the through hole, and the lifting plate 41 can be guaranteed to ascend through the extrusion rod 44 when the lifting plate 41 ascends.
A communication groove 71 is formed in the isolation mechanism 7, two symmetrical isolation sliding blocks 72 are installed in the communication groove 71 through springs, and an extrusion groove 73 is formed in the top surface of the isolation mechanism 7;
the positions of the extrusion grooves 73 are in one-to-one correspondence with the positions of the extrusion rods 44, and the positions, close to the extrusion grooves 73, of the two sides of the isolation sliding blocks 72 are provided with inclined grooves;
as shown in fig. 3 and 4, when filling 50ml injection bottles, first hydraulic cylinder 31 is opened first, first hydraulic cylinder 31 can drive lifting plate 41 through hydraulic rod to make lifting plate 41 vertically descend, after filling mechanism 5 contacts with isolating mechanism 7, first air-discharging block 51 at bottom surface of filling mechanism 5 can exhaust air of isolating mechanism 7, at the same time, because air pump 46 is communicated with first high-pressure cavity 53 through pipeline, high-temperature air is collected in first high-pressure cavity 53 to repel ambient air, when lifting plate 41 continues to be pressed down, because position of pressing groove 73 corresponds to position of pressing rod 44 one by one, pressing rod 44 is inserted into pressing groove 73 and acts on chute of isolating slide 72, as shown in fig. 8, chute can receive vertically downward acting force, according to force decomposition, isolating slide 72 can slide in communicating groove 71 against spring force, so that communicating groove 71 can be opened, and second hydraulic cylinder 43 is opened after communicating groove 71 is completely opened;
the second hydraulic cylinder 43 can drive the lifting filling pipe 451 through a hydraulic rod, so that the lifting filling pipe 451 descends along the pipe sleeve 52 and sequentially passes through the first high-pressure cavity 53 and the communication groove 71, and finally stretches into a 50ml injection bottle, calcium gluconate injection can be injected into the 50ml injection bottle through the lifting filling pipe 451, after the calcium gluconate injection is filled, the lifting filling pipe 451 is lifted through the second hydraulic cylinder 43, the lifting filling pipe 451 is retracted into the pipe sleeve 52 again, and the lifting plate 41 is lifted through the hydraulic cylinder 31;
the lifting of the lifting plate 41 is divided into two stages, wherein the first stage is that the extrusion rod 44 is separated from the extrusion groove 73, so that the acting force of the chute is lost, the isolation slide block 72 can reclose the communication groove 71 under the action of spring elastic force, the inner cavity of the aseptic cabinet 1 is isolated from the external environment, and the second stage is that the lifting plate 41 can drive the filling mechanism 5 through the extrusion rod 44, so that the filling mechanism 5 is separated from the isolation mechanism 7 and returns to the initial position for cyclic operation.
Example 2:
as shown in fig. 1 to 9, the encapsulating device for preparing calcium gluconate injection comprises an ultra-high temperature cabinet 12, a cleaning cabinet 11 which is connected with one end of the ultra-high temperature cabinet 12 in a sealing way, and a sterile cabinet 1 which is connected with the other end of the ultra-high temperature cabinet 12 in a sealing way;
the top surface fixedly connected with two sets of risers 3 of aseptic cabinet 1, the top surface of riser 3 can be dismantled and be connected with first pneumatic cylinder 31, still includes:
the high-pressure driving mechanism 4 is detachably connected with a hydraulic rod of the first hydraulic cylinder 31, and the high-pressure driving mechanism 4 is connected with the ultra-high temperature cabinet 12 through a pipeline and is used for absorbing high-temperature gas in the ultra-high temperature cabinet 12 so as to generate high pressure in the high-pressure driving mechanism 4;
the filling mechanism 5 is movably arranged at the bottom of the left high-pressure driving mechanism 4 and is used for transporting calcium gluconate injection;
the sealing mechanism 6 is movably arranged at the bottom of the right high-pressure driving mechanism 4 and is used for sealing the calcium gluconate injection;
the isolation mechanism 7 is arranged on the top surface of the aseptic cabinet 1 and is close to the vertical plate 3, and the isolation mechanism 7 is used for isolating the internal space of the aseptic cabinet 1 and matching with the high-pressure driving mechanism 4;
the high-pressure driving mechanism 4 comprises a lifting plate 41, and the bottom end of a hydraulic rod of the first hydraulic cylinder 31 is detachably connected with the top surface of the lifting plate 41;
the side plate 42 is fixedly arranged on the top surface of the lifting plate 41, and the top end of the side plate 42 is detachably connected with the second hydraulic cylinder 43;
the extrusion rod 44, the extrusion rod 44 is fixedly connected with the bottom surface of the lifting plate 41;
a high-pressure elevating member 45, wherein the high-pressure elevating member 45 is slidably disposed inside the side plate 42, and the hydraulic rod of the second hydraulic cylinder 43 is detachably connected with the high-pressure elevating member 45;
the air pump 46 is detachably arranged on the side surface of the side plate 42, and the air pump 46 is connected with the ultra-high temperature cabinet 12 and the high-pressure lifting piece 45 through a pipeline;
in operation, taking 100ml of calcium gluconate injection as an example, as shown in fig. 9, a conveying belt 2 for conveying 100ml of injection bottles is arranged in a sterile cabinet 1, a cleaning cabinet 11 and an ultra-high temperature cabinet 12, firstly, 50ml of injection bottles can be placed on the conveying belt 2 corresponding to the cleaning cabinet 11, the conveying belt 2 can convey 100ml of injection bottles into the ultra-high temperature cabinet 12, the temperature of the ultra-high temperature cabinet 12 is regulated to ensure that the temperature in the ultra-high temperature cabinet 12 is between 135 ℃ and 150 ℃, the ultra-high temperature cabinet 12 can adopt resistance heating, the moving speed of the conveying belt 2 is regulated, so that 100ml of injection bottles can stay in the ultra-high temperature cabinet 12 for 2 to 8 seconds, and the ultra-high temperature cabinet 12 can boil water drops remained when the 100ml of injection bottles are clear, thereby achieving the effect of drying;
after sterilization by the ultra-high temperature cabinet 12, the conveying belt 2 can continuously convey 100ml injection liquid bottles into the aseptic cabinet 1, the filling mechanism 5 arranged on the aseptic cabinet 1 can perform filling operation on the 100ml injection liquid bottles, specifically, calcium gluconate injection liquid is injected into the 100ml injection liquid bottles, as shown in fig. 3, the filling mechanism 5 is arranged between the high-pressure driving mechanism 4 and the isolation mechanism 7, the high-pressure driving mechanism 4 is connected with the ultra-high temperature cabinet 12 through a pipeline, high-temperature gas in the ultra-high temperature cabinet 12 can be absorbed, the high-temperature gas enables the high-pressure driving mechanism 4 to generate high pressure, so that external air can be repelled, the high-temperature gas in the ultra-high temperature cabinet 12 is aseptic gas, and therefore, the filling mechanism 5 can be ensured not to be polluted by external environment when the filling operation is performed, and also, as shown in fig. 5, the sealing mechanism 6 is arranged between the high-pressure driving mechanism 4 and the isolation mechanism 7, and therefore, the sealing mechanism 6 can be ensured not to be polluted by external environment when the filling operation is performed.
The top surface of the sealing mechanism 6 is provided with a through hole which is matched with the extrusion rod 44 in a penetrating way at a position close to the extrusion rod 44, the bottom surface of the sealing mechanism 6 is fixedly connected with a second air exhaust block 61, and the middle position of the front surface of the sealing mechanism 6 is fixedly connected with a feeding plate 62;
the high-pressure lifting member 45 is a lifting pressure rod 452, the top surface of the sealing mechanism 6 is fixedly connected with a rod sleeve 63 matched with the lifting pressure rod 452, a second high-pressure cavity 64 is formed in the bottom surface of the second air exhaust block 61 near the lifting pressure rod 452, the rod sleeve 63 is communicated with the second high-pressure cavity 64, and the air pump 46 is communicated with the second high-pressure cavity 64 through a pipeline;
a spring is nested at a position between the side surface of the extrusion rod 44, which is close to the lifting plate 41, and the sealing mechanism 6, the bottom surface of the extrusion rod 44 is fixedly connected with an arc-shaped block, and the diameter of the arc-shaped block is larger than that of the through hole;
a communication groove 71 is formed in the isolation mechanism 7, two symmetrical isolation sliding blocks 72 are installed in the communication groove 71 through springs, and an extrusion groove 73 is formed in the top surface of the isolation mechanism 7;
the positions of the extrusion grooves 73 are in one-to-one correspondence with the positions of the extrusion rods 44, and the positions, close to the extrusion grooves 73, of the two sides of the isolation sliding blocks 72 are provided with inclined grooves;
when a 100ml injection bottle is sealed, as shown in fig. 5 and 6, the first hydraulic cylinder 31 is opened first, the first hydraulic cylinder 31 can drive the lifting plate 41 through a hydraulic rod to enable the lifting plate 41 to descend along the vertical direction, after the filling mechanism 5 contacts the isolation mechanism 7, the first air discharging block 51 on the bottom surface of the filling mechanism 5 can discharge air of the isolation mechanism 7, meanwhile, the air pump 46 is communicated with the second high-pressure cavity 64 through a pipeline, so that high-temperature air is collected in the second high-pressure cavity 64 to repel ambient air, when the lifting plate 41 is continuously pressed down, the position of the pressing groove 73 corresponds to the position of the pressing rod 44 one by one, so that the pressing rod 44 can be inserted into the pressing groove 73 and acts on a chute of the isolation slider 72, as shown in fig. 8, the chute can be subjected to vertical downward acting force, according to the force decomposition, the chute can generate horizontal acting force to enable the isolation slider 72 to slide in the communication groove 71 against the spring force, so that the communication groove 71 can be opened, and after the communication groove 71 is completely opened, the second hydraulic cylinder 43 is opened;
the second hydraulic cylinder 43 can drive the lifting pressure lever 452 through the hydraulic rod, the lifting pressure lever 452 can descend along the lever sleeve 63, a conveying groove for conveying the bottle stopper is formed in the feeding plate 62, the conveying groove can convey the bottle stopper to the second high-pressure cavity 64, the lifting pressure lever 452 descending along the lever sleeve 63 can act on the top surface of the bottle stopper, the bottle stopper is usually made of rubber, in order to enable the bottle stopper to be matched with a 100ml injection bottle, a negative pressure channel can be formed in the lifting pressure lever 452, one end of the negative pressure channel is connected with the negative pressure pump, the other end of the negative pressure channel is arranged on the bottom surface of the lifting pressure lever 452, negative pressure formed by the negative pressure channel can enable the bottle stopper to be adsorbed on the bottom surface of the lifting pressure lever 452, therefore the lifting pressure lever 452 can drive the bottle stopper to pass through the communicating groove 71, finally enable the bottle stopper to be clamped on the bottle opening of the 100ml injection bottle, sealing of the 100ml injection bottle is achieved, after calcium gluconate injection bottle sealing is completed, the lifting filling pipe 451 is lifted up into the lever sleeve 63 again through the second hydraulic cylinder 31, and the lifting plate 41 is lifted through the hydraulic cylinder 31, and all mechanisms are returned to the initial positions for circulating operation.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the foregoing embodiments, and that the foregoing embodiments and description are merely illustrative of the principles of the invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (10)

1. A filling and sealing device for preparing calcium gluconate injection comprises an ultrahigh Wen Gui (12), a cleaning cabinet (11) connected with one end of the ultrahigh Wen Gui (12) in a sealing way, and a sterile cabinet (1) connected with the other end of the ultrahigh Wen Gui (12) in a sealing way;
the method is characterized in that: the top surface fixedly connected with two sets of risers (3) of aseptic cabinet (1), the top surface of riser (3) is dismantled and is connected with first pneumatic cylinder (31), still includes:
the high-pressure driving mechanism (4) is detachably connected with a hydraulic rod of the first hydraulic cylinder (31), and the high-pressure driving mechanism (4) is connected with the ultrahigh Wen Gui (12) through a pipeline and is used for absorbing high-temperature gas in the ultrahigh Wen Gui (12) so as to generate high pressure in the high-pressure driving mechanism (4);
the filling mechanism (5) is movably arranged at the bottom of the left high-pressure driving mechanism (4) and is used for transporting calcium gluconate injection;
the sealing mechanism (6) is movably arranged at the bottom of the right high-pressure driving mechanism (4) and is used for sealing the calcium gluconate injection;
the isolation mechanism (7), isolation mechanism (7) set up in the top surface of aseptic cabinet (1) be close to riser (3) position, isolation mechanism (7) are used for keeping apart aseptic cabinet (1) inner space and cooperation high pressure actuating mechanism (4).
2. The filling and sealing device for preparing calcium gluconate injection according to claim 1, wherein the filling and sealing device is characterized in that: the high-pressure driving mechanism (4) comprises a lifting plate (41), and the bottom end of a hydraulic rod of the first hydraulic cylinder (31) is detachably connected with the top surface of the lifting plate (41);
the side plate (42) is fixedly arranged on the top surface of the lifting plate (41), and the top end of the side plate (42) is detachably connected with a second hydraulic cylinder (43);
the extrusion rod (44), the said extrusion rod (44) is fixedly connected with bottom surface of the lifting plate (41);
the high-pressure lifting piece (45) is arranged on the inner side of the side plate (42) in a sliding manner, and a hydraulic rod of the second hydraulic cylinder (43) is detachably connected with the high-pressure lifting piece (45);
the air pump (46), the side at curb plate (42) can be dismantled to air pump (46), air pump (46) are through the superelevation Wen Gui (12) and high-pressure lifting piece (45) of pipe connection.
3. The filling and sealing device for preparing calcium gluconate injection according to claim 2, wherein: the top surface of filling mechanism (5) is close to the position of extrusion pole (44) and runs through the through-hole that agrees with extrusion pole (44), the bottom surface fixedly connected with first exhaust piece (51) of filling mechanism (5).
4. A potting device for preparing a calcium gluconate injection according to claim 3, wherein: the high-pressure lifting part (45) is a lifting filling pipe (451), a pipe sleeve (52) matched with the lifting filling pipe (451) is fixedly connected to the top surface of the filling mechanism (5), a first high-pressure cavity (53) is formed in the position, close to the lifting filling pipe (451), of the bottom surface of the first air exhaust block (51), the pipe sleeve (52) is communicated with the first high-pressure cavity (53), and the air pump (46) is communicated with the first high-pressure cavity (53) through a pipeline.
5. A potting device for preparing a calcium gluconate injection according to claim 3, wherein: the side of the extrusion rod (44) is close to a position between the lifting plate (41) and the filling mechanism (5), a spring is nested, the bottom surface of the extrusion rod (44) is fixedly connected with an arc-shaped block, and the diameter of the arc-shaped block is larger than that of the through hole.
6. The filling and sealing device for preparing calcium gluconate injection according to claim 2, wherein: the top surface of sealing mechanism (6) is close to the through-hole that is fit with extrusion rod (44) runs through in the position of extrusion rod (44), the bottom surface fixedly connected with second exhaust piece (61) of sealing mechanism (6), the front intermediate position fixedly connected with feed plate (62) of sealing mechanism (6).
7. The filling and sealing device for preparing calcium gluconate injection according to claim 6, wherein: the high-pressure lifting part (45) is a lifting pressure rod (452), a rod sleeve (63) matched with the lifting pressure rod (452) is fixedly connected to the top surface of the sealing mechanism (6), a second high-pressure cavity (64) is formed in the position, close to the lifting pressure rod (452), of the bottom surface of the second air exhaust block (61), the rod sleeve (63) is communicated with the second high-pressure cavity (64), and the air pump (46) is communicated with the second high-pressure cavity (64) through a pipeline.
8. The filling and sealing device for preparing calcium gluconate injection according to claim 6, wherein: the side of the extrusion rod (44) is close to a position between the lifting plate (41) and the sealing mechanism (6), a spring is nested, the bottom surface of the extrusion rod (44) is fixedly connected with an arc-shaped block, and the diameter of the arc-shaped block is larger than that of the through hole.
9. The filling and sealing device for preparing calcium gluconate injection according to claim 2, wherein: the inside of isolation mechanism (7) has seted up intercommunication groove (71), intercommunication groove (71) are installed two symmetrical isolation slider (72) through the spring, extrusion groove (73) have been seted up to the top surface of isolation mechanism (7).
10. The filling and sealing device for preparing calcium gluconate injection according to claim 9, wherein: the positions of the extrusion grooves (73) are in one-to-one correspondence with the positions of the extrusion rods (44), and inclined grooves are formed in the positions, close to the extrusion grooves (73), of the two sides of the isolation sliding blocks (72).
CN202210616209.5A 2022-06-01 2022-06-01 Filling and sealing device for preparing calcium gluconate injection Active CN114772535B (en)

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CN114772535B true CN114772535B (en) 2023-07-18

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0655613B2 (en) * 1988-03-31 1994-07-27 凸版印刷株式会社 Aseptic filling and packaging equipment
JP2856057B2 (en) * 1993-12-28 1999-02-10 東洋製罐株式会社 Method and apparatus for filling carbonated beverages
JP5232568B2 (en) * 2008-08-12 2013-07-10 三菱重工食品包装機械株式会社 Aseptic filling equipment for carbonated beverages
CN105730783A (en) * 2011-10-25 2016-07-06 大日本印刷株式会社 Beverage filling method and apparatus
JP6859740B2 (en) * 2017-02-22 2021-04-14 東洋製罐株式会社 Aseptic filling system and aseptic filling method
CN211468858U (en) * 2019-12-20 2020-09-11 云山化妆品研究开发(广州)有限公司 Sterile filling equipment
CN214268039U (en) * 2020-12-31 2021-09-24 北京晴川健康科技股份有限公司 Oral liquid production conveyor
CN214792421U (en) * 2021-04-28 2021-11-19 江苏浦金药业有限公司 Tunnel sterilization dryer for preparing toad venom injection

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