CN114746438A - 通过靶向成纤维细胞激活蛋白(fap)使肿瘤组织破裂 - Google Patents

通过靶向成纤维细胞激活蛋白(fap)使肿瘤组织破裂 Download PDF

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CN114746438A
CN114746438A CN202080079493.6A CN202080079493A CN114746438A CN 114746438 A CN114746438 A CN 114746438A CN 202080079493 A CN202080079493 A CN 202080079493A CN 114746438 A CN114746438 A CN 114746438A
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cell
seq
cells
fap
amino acid
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S·A·阿尔贝尔达
E·普尔
L·托德
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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CN202080079493.6A 2019-09-23 2020-09-23 通过靶向成纤维细胞激活蛋白(fap)使肿瘤组织破裂 Pending CN114746438A (zh)

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US201962904340P 2019-09-23 2019-09-23
US62/904,340 2019-09-23
PCT/US2020/052227 WO2021061778A1 (en) 2019-09-23 2020-09-23 Disrupting tumor tissues by targeting fibroblast activation protein (fap)

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US (2) US12116418B2 (https=)
EP (1) EP4034554A4 (https=)
JP (1) JP7621344B2 (https=)
KR (1) KR20220066312A (https=)
CN (1) CN114746438A (https=)
AU (1) AU2020353000A1 (https=)
BR (1) BR112022005423A2 (https=)
CA (1) CA3151550A1 (https=)
IL (1) IL291342A (https=)
MX (1) MX2022003466A (https=)
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AU2020353000A1 (en) 2019-09-23 2022-04-07 The Trustees Of The University Of Pennsylvania Disrupting tumor tissues by targeting fibroblast activation protein (FAP)
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CN119060202A (zh) * 2024-08-12 2024-12-03 华中科技大学同济医学院附属协和医院 一种靶向fap的嵌合抗原受体调节性t细胞、其制备方法与应用
CN119074926B (zh) * 2024-08-29 2025-11-25 中国医学科学院阜外医院深圳医院(深圳市孙逸仙心血管医院) 一种靶向fap的car-t细胞在制备治疗心肌炎慢性期心脏纤维化的药物中的应用
CN119591719B (zh) * 2024-11-25 2025-10-21 江苏集萃崛创生物科技研究所有限公司 靶向fap的纳米抗体、car-t细胞及其应用

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