CN114736776A

CN114736776A - Filter equipment of bio-pharmaceuticals reactor

Info

Publication number: CN114736776A
Application number: CN202210334524.9A
Authority: CN
Inventors: 秦孙星
Original assignee: Shanghai Lepure Biotech Co ltd
Current assignee: Shanghai Lepure Biotech Co ltd
Priority date: 2022-03-30
Filing date: 2022-03-30
Publication date: 2022-07-12
Anticipated expiration: 2042-03-30
Also published as: CN114736776B

Abstract

The invention relates to the technical field of biological pharmacy, and particularly discloses a filtering device of a biological pharmacy reactor. Including the sealed lid that is used for sealing the fermentation cylinder and the filter assembly of setting in the fermentation cylinder, filter assembly includes from last first filter screen and the second filter screen that sets gradually extremely down, it is equipped with the screw rod that is used for controlling first filter screen up-and-down motion to rotate on the second filter screen, it is equipped with a plurality of vortex poles to rotate on the screw rod, the one end that the screw rod was kept away from to the vortex pole all is equipped with can be at the rolling drive wheel of second filter screen inner wall, equal rigid coupling has a plurality of first spoilers on the vortex pole, the rigid coupling has interior ring gear on the second filter screen, interior ring gear inner gearing has a plurality of drive gear, equal rigid coupling has the bracing piece with first filtration sliding connection and with sealed lid rigid coupling on the drive gear, the bracing piece is close to the equal rigid coupling of one end of second filter screen and has a plurality of second spoilers. The invention aims to solve the problem that the reaction rate is slow in the use process of the traditional biological pharmacy fermentation tank.

Description

Filter equipment of bio-pharmaceuticals reactor

Technical Field

The application relates to the technical field of biological pharmacy, and particularly discloses a filtering device of a biological pharmacy reactor.

Background

The biological pharmaceutical raw materials mainly comprise natural biological materials, including microorganisms, human bodies, animals, plants, marine organisms and the like. With the development of biotechnology, purposely artificially prepared biological raw materials become the main source of the current biopharmaceutical raw materials. Such as animal material prepared by immunization, microorganism or other cell material prepared by changing gene structure, etc. The biological medicine has the features of high pharmacological activity, less toxic side effect and high nutritive value. The biological medicine mainly comprises protein, nucleic acid, saccharide, lipid, etc. The composition units of the substances are amino acid, nucleotide, monosaccharide, fatty acid and the like, and the substances are not only harmless to human bodies but also important nutrient substances.

The biological medicine has wide application foreground, and may be used widely in treating various diseases, such as cancer, AIDS, coronary heart disease, anemia, dysplasia, diabetes, etc. Most of the antibiotics used in medicine come from microorganisms, such as erythromycin, lincomycin and the like, and penicillin, streptomycin, gentamicin and the like for injection. The biological medicine has huge formation and rapid development. Half of the worldwide pharmaceuticals have been biosynthesized, and particularly, when a drug with a complex molecular structure is synthesized, the method is simpler and more economic than a chemical synthesis method.

In the biological pharmacy, drug producing bacteria must be put into a fermentation tank for production, during production, the preserved bacteria slant is transferred to a shake flask for culture, the grown shake flask seeds are inoculated into a seeding tank with large culture quantity, and can be inoculated into the fermentation tank for culture after growth, and when biological culture is carried out in the fermentation tank, the conditions for strictly controlling culture need to be created so as to facilitate the growth of specific organisms. In the fermentation tank, the drug can be produced by the organism, but in the fermentation process, in order to avoid the environment in the fermentation tank from losing balance, the organism is usually required to be completely sealed before the fermentation is completed, and when the organism reacts in the fermentation tank, the organism can generate byproducts which are opposite to the production requirement, or when the reactant concentration is too high, the reaction becomes slow, particularly some caking reactants, and the finishing can improve the pharmaceutical cycle if the finishing is not completed in time, so the inventor has the problem that a filtering device of the biological pharmaceutical reactor is provided to solve the problem.

Disclosure of Invention

The invention aims to solve the problem that the reaction rate is slow in the use process of the traditional biological pharmacy fermentation tank.

In order to achieve the above object, the basic scheme of the present invention provides a filtering device of a bio-pharmaceutical reactor, comprising a sealing cover for sealing a fermentation tank and a filtering component arranged in the fermentation tank, wherein the filtering component comprises a first filtering net and a second filtering net which are sequentially arranged from top to bottom, the second filtering net is rotatably provided with a screw rod for controlling the first filtering net to reciprocate up and down, the screw rod is rotatably provided with a plurality of turbulence bars, one ends of the turbulence bars, far away from the screw rod, are respectively provided with a driving wheel capable of rolling on the inner wall of the second filtering net, the turbulence bars are respectively fixedly connected with a plurality of first turbulence plates, the second filtering net is fixedly connected with an inner toothed ring, the inner toothed ring is internally engaged with a plurality of driving gears, the driving gears are respectively fixedly connected with a supporting rod which is slidably connected with the first filtering net and is fixedly connected with the sealing cover, one ends of the supporting rods, close to the second filtering net, are respectively fixedly connected with a plurality of second turbulence plates, the sealing cover is provided with a motor for providing power for the screw rod.

The principle and effect of this basic scheme lie in:

1. when the fermentation tank is used for biological pharmacy, raw materials for biological pharmacy such as various production bacteria and nutrient solution are inoculated, then the sealing cover is used for sealing operation, and the first filter screen and the second filter screen are arranged on the inner bottom surface of the fermentation tank for subsequent reaction work.

2. In reaction process, if appear after the reactant of caking class or the condition of by-product influence reaction rate, just can the starter motor, utilize the meshing of screw rod and first filter screen, alright make first filter screen accomplish ascending filtering movement, caking alright in this in-process nutrient solution is extracted the upper portion of fermentation cylinder through first filter screen, the fermentation cylinder bottom still can be normal carry out bio-pharmaceuticals work this moment, simultaneously because reactant of caking class or by-product filter and promote to the top of fermentation cylinder after from the fermentation cylinder bottom, the effectual influence of caking to the reaction that has reduced, thereby alright improve reaction rate.

3. In the process that first filter screen promoted, can rotate along with the rotation of screw rod, consequently can provide certain centrifugal force for the thing filtered in the first filter screen, through these centrifugal forces, can effectual reduction caking surface's absorption liquid, improve the filter effect.

4. When first filter screen upward movement, can upwards lift up some raw materialss in fermentation cylinder bottom, extrude some raw and other materials on fermentation cylinder upper portion downwards simultaneously, alright like this with the raw and other materials of lower part on fermentation cylinder upper portion after reaction one end time, carry out the mixing operation again, improve reaction effect.

5. In the rotation process of the screw, the turbulence rods are driven to rotate by taking the screw as the center of a circle, so that a turbulence motion of a horizontal filter screen and a second filter screen is formed, various raw materials are fully mixed after the filtration is finished, and the subsequent reaction rate is improved; when the horizontal circular motion is done at the vortex pole, the drive wheel of being connected with the vortex pole rotates at the inner wall of first filter screen to effectual drive vortex pole self takes place to rotate, and when vortex pole self took place to rotate, the rotation takes place for the first spoiler of further drive again, finally rotates around the screw rod through the vortex pole and the rotation that the vortex pole drove first spoiler self, solves the problem of the interior level of fermentation tank and vertical raw and other materials intermixture once more.

6. When first filter screen rotated, can drive the bracing piece and carry out circular motion on the second filter screen, and the lower extreme of bracing piece has all set up the drive gear with interior ring gear meshing, consequently when the bracing piece revolves around the screw rod, through rigid coupling inner ring gear and drive gear's on the second filter screen meshing, alright take place the rotation of bracing piece, at the in-process of bracing piece rotation, can drive the second spoiler and take place to rotate bottom the second filter screen, thereby the raw materials that is located the heavier quality on the second filter screen of once more upwards mixes, the speed of biological reaction is improved.

7. After the reaction is completed, the first filter screen and the second filter screen are all lifted out of the fermentation tank through the sealing cover, and the second filter screen can filter the caking generated by the reaction again after the first filter screen is filtered so as to ensure the subsequent production.

Compared with the prior art, the invention can carry out primary filtration in the reaction middle section through the first filter screen which reciprocates in the use process, and simultaneously complete the secondary mixing work of reaction raw materials in the filtration process, has stable operation and convenient and fast use, effectively improves the fermentation reaction rate while ensuring the closed space of the fermentation tank, thereby being convenient for popularization and use in the field.

Furthermore, the bracing piece includes the first bracing piece with the drive gear rigid coupling and with the second bracing piece of sealed lid rigid coupling, and polygonal spread groove has all been opened to first bracing piece upper end, and the equal rigid coupling of lower extreme of second bracing piece has the polygon connecting block that can insert the spread groove, and the one end rigid coupling of second bracing piece orientation first bracing piece has the haulage rope that links to each other with first bracing piece. Through connecting the rope, be convenient for follow-up clearance operation to filtering the thing, simultaneously through polygonal connecting block and spread groove, when first bracing piece pivoted, relative rotation also can be carried out to the second bracing piece.

Further, all open a plurality of antiskid groove on the second bracing piece, be equipped with on the first filter screen a plurality of joints in the protecting groove and with second bracing piece sliding connection's function cover, the equal rigid coupling has a plurality of third spoilers on the function cover. Rotate through the second bracing piece, can effectually drive the third spoiler of function cover and rigid coupling on the function cover and rotate to mix the raw materials of first filter screen top.

Furthermore, be equipped with a plurality of regulation archs that are used for first vortex ring to insert on the first filter screen. The position of the first filter screen can be effectively reduced, and the primary filtering effect is further improved to a certain extent.

Further, the second filter screen rotates on and is equipped with the screw rod mount pad, and the vortex pole all rotates with the screw rod mount pad to be connected, and open screw rod mount pad upper end has polygonal spacing groove, and the lower extreme rigid coupling of screw rod has the polygonal spacing post that can insert the spacing groove. The subsequent use and installation work are convenient.

Furthermore, the inner wall of the second filter screen is fixedly connected with a function groove capable of allowing the driving wheel to roll, and a plurality of contact bulges for increasing friction force are arranged in the function groove. The rotational stability of the turbulence bar is improved.

Furthermore, a plurality of rubber hanging plates contacting with the inner wall of the fermentation tank are fixedly connected to the outer wall of the first filter screen. The reactant adsorbed on the inner wall of the fermentation tank can be cleaned in the movement process of the first filter screen.

Furthermore, a closable feed pipe is communicated with the sealing cover, and a controlled valve is arranged in the feed pipe. The starting materials may be added as required during the reaction.

Furthermore, a piston tube is communicated with the sealing cover, and a functional piston is arranged in the piston tube in a sliding mode. Can effectively balance the air pressure in the fermentation tank.

Furthermore, a plurality of traction lugs which are convenient for the sealing cover to lift are fixedly connected to the sealing cover. Facilitating the lifting of the sealing cover.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a schematic view illustrating a sealing cover of a filtering apparatus of a biopharmaceutical reactor according to an embodiment of the present application;

FIG. 2 is a schematic diagram illustrating a filter assembly of a filtering apparatus of a biopharmaceutical reactor according to an embodiment of the present application;

fig. 3 is a schematic diagram illustrating a support rod of a filtering apparatus of a biopharmaceutical reactor according to an embodiment of the present application;

fig. 4 shows a top view of a second filter screen in a filtering apparatus of a biopharmaceutical reactor according to an embodiment of the present application.

Fig. 5 illustrates a cross-sectional view of a piston tube in a filtration apparatus of a biopharmaceutical reactor according to an embodiment of the present application.

Detailed Description

To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the following detailed description of the embodiments, structures, features and effects according to the present invention will be made with reference to the accompanying drawings and preferred embodiments.

Reference numerals in the drawings of the specification include: the fermentation tank comprises a fermentation tank 1, a sealing cover 2, a motor 3, a traction lug 4, a piston tube 5, a lock catch 6, a second support rod 7, a silica gel hanging plate 8, a first filter screen 9, a contact protrusion 10, a spoiler 11, a first spoiler 12, a transmission wheel 13, a second filter screen 14, a function groove 15, a second spoiler 16, an inner toothed ring 17, a first support rod 18, a traction rope 19, a screw rod 20, an anti-slip groove 21, a transmission gear 22, a function piston 23, a function sleeve 24 and a third spoiler 25.

The embodiment is shown in figure 1, a fermentation tank 1 is placed on the bottom surface, a sealing cover 2 is buckled at the top of the fermentation tank 1, four buckles 6 for tightly buckling the sealing cover 2 on the fermentation tank 1 are rotatably arranged on the outer wall of the sealing cover 2, a closable feeding pipe is communicated with the sealing cover 2, a solenoid valve is arranged in the feeding pipe, a piston pipe 5 is communicated with the sealing cover 2, a functional piston 23 is arranged in the piston pipe 5 in a sliding mode as shown in figure 5, and four traction lugs 4 convenient for lifting the sealing cover 2 are welded on the sealing cover 2 as shown in figure 1.

As shown in fig. 2 and 4, the filter comprises a second filter screen 14, a screw 20 mounting seat is rotatably arranged in the middle of the second filter screen 14, two spoiler bars 11 are rotatably arranged on the side wall of the screw 20 mounting seat, a driving wheel 13 capable of rolling on the inner wall of the second filter screen 14 is fixedly arranged at one end of each spoiler bar 11 far away from the screw 20, a plurality of first spoiler plates 12 are welded on the outer wall circumference of each spoiler bar 11 in an aligned manner, a hexagonal limiting groove is formed at the upper end of the screw 20 mounting seat, a hexagonal limiting column capable of being inserted into the limiting groove is welded at the lower end of the screw 20, as shown in fig. 1, a servo motor 3 for providing a power source for the screw 20 is arranged on a sealing cover 2, as shown in fig. 2 and 4, a function groove 15 capable of accommodating the driving wheel 13 to roll is welded on the inner wall of the second filter screen 14, a plurality of contact protrusions 10 for increasing friction force are arranged in the function groove 15, an inner toothed ring 17 is welded on the upper surface of the second filter 14, and two transmission gears 22 are meshed in the inner toothed ring 17.

As shown in fig. 2 and 3, a first support rod 18 is welded to an upper surface of each of the transmission gears 22, two second support rods 7 are welded to an inner top surface of the sealing cover 2, a hexagonal coupling groove is formed at an upper end of each of the first support rods 18, a hexagonal coupling block insertable into the coupling groove is welded to a lower end of each of the second support rods 7, the lower end of each of the second support rods 7 and an upper end of each of the first support rods 18 are coupled to each other by a traction rope 19, as shown in fig. 2, four anti-slip grooves 21 are formed in each second support rod 7, two functional sleeves 24 which are connected with the second support rods 7 in a sliding manner and are clamped in the protective grooves are arranged on the first filter screen 9, a plurality of third spoilers 25 are welded on each functional sleeve 24, a plurality of adjusting protrusions for inserting the first spoilers are arranged on the first filter screen 9, and a plurality of rubber hanging plates which are in contact with the inner wall of the fermentation tank 1 are adhered to the outer wall of the first filter screen 9.

Before using, install a hoist and mount driving in the workshop, then install sealed lid 2 on hoist and mount driving through cable wire and traction ear 4, connect solenoid valve and servo motor 3, put through the filling tube, alright begin the service function.

Putting the mixed raw materials into a fermentation tank 1, then covering a sealing cover 2, buckling a lock catch 6, completely placing a first filter screen 9 and a second filter screen 14 at the bottom of the fermentation tank 1, and enabling the first filter screen 9 to be close to the second filter screen; the subsequent reaction pharmacy work can be carried out.

In the reaction process, if the reaction rate is influenced by the caking reactants or byproducts, the motor 3 can be started, the first filter screen 9 can finish upward filtering movement by utilizing the meshing of the screw rod 20 and the first filter screen 9, the caking in the nutrient solution can be extracted to the upper part of the fermentation tank 1 through the first filter screen 9 in the process, the bottom of the fermentation tank 1 can still normally carry out the biopharmaceutical work, and meanwhile, the influence of the caking on the reaction is effectively reduced after the caking reactants or byproducts are filtered from the bottom of the fermentation tank 1 and lifted to the top of the fermentation tank 1, so that the reaction rate can be improved; in the process of lifting the first filter screen 9, the first filter screen can rotate along with the rotation of the screw 20, so that certain centrifugal force can be provided for the filtered object in the first filter screen 9, and the adsorbed liquid on the surface of the agglomeration can be effectively reduced by the centrifugal force; when the first filter screen 9 moves upwards, a part of raw materials at the bottom of the fermentation tank 1 can be lifted upwards, and meanwhile, some raw materials at the upper part of the fermentation tank 1 are extruded downwards, so that the raw materials at the upper part of the fermentation tank 1 and the raw materials at the lower part can be mixed again after reacting for a period of time, and the reaction effect is improved.

In the rotation process of the screw 20, the plurality of turbulence rods 11 are driven to rotate by taking the screw 20 as the center of a circle, so that a turbulence motion with the second filter screen 14 horizontally is formed, and after the filtration is finished, various raw materials are fully mixed, so that the subsequent reaction rate is improved; when the spoiler 11 makes a horizontal circular motion, the driving wheel 13 connected with the spoiler 11 rotates on the inner wall of the first filter screen 9, so that the spoiler 11 is effectively driven to rotate, when the spoiler 11 rotates, the first spoiler 12 is further driven to rotate, and finally, the spoiler 11 rotates around the screw rod 20 and the spoiler 11 drives the first spoiler 12 to rotate, so that the problem that horizontal and vertical raw materials in the fermentation tank 1 are mixed with each other is solved again; when the first filter screen 9 rotates, the support rod can be driven to do circular motion on the second filter screen 14, and the lower end of the support rod is provided with the transmission gear 22 meshed with the inner toothed ring 17, so that when the support rod revolves around the screw 20, the support rod can rotate by being meshed with the inner toothed ring 17 fixedly connected to the second filter screen 14 and the transmission gear 22, and the second spoiler 16 can be driven to rotate at the bottom of the second filter screen 14 in the rotation process of the support rod, so that the raw materials with heavier mass on the second filter screen 14 are mixed upwards again, the biological reaction rate is improved, in the reaction process, the electromagnetic valve can be opened, and the raw materials are added to the fermentation tank 1 according to the use requirements.

After the reaction is finished, the lock catch 6 is opened, the travelling crane is started, the sealing cover 2 can be lifted up, the first filter screen 9 and the second filter screen 14 are all lifted out of the fermentation tank 1 through the sealing cover 2, and the second filter screen 14 can filter the caking generated by the reaction after the first filter screen 9 is filtered.

In the using process of the invention, the first filter screen 9 which reciprocates can be used for preliminary filtering in the reaction middle section, and meanwhile, in the filtering process, the secondary mixing work of reaction raw materials is completed, the operation is stable, the use is convenient, and the fermentation reaction rate is effectively improved while the closed space of the fermentation tank 1 is ensured, thus being convenient for popularization and use in the field.

Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

1. A filtration apparatus for a biopharmaceutical reactor, comprising: including the sealed lid that is used for sealing the fermentation cylinder and the filter assembly of setting in the fermentation cylinder, filter assembly includes from last first filter screen and the second filter screen that sets gradually extremely down, it is equipped with the screw rod that is used for controlling first filter screen up-and-down motion to rotate on the second filter screen, it is equipped with a plurality of vortex poles to rotate on the screw rod, the one end that the screw rod was kept away from to the vortex pole all is equipped with can be at the rolling drive wheel of second filter screen inner wall, equal rigid coupling has a plurality of first spoilers on the vortex pole, the rigid coupling has the inner ring gear on the second filter screen, the inner ring gear inner gearing has a plurality of drive gear, equal rigid coupling has the bracing piece with first filtration sliding connection and with sealed lid rigid coupling on the drive gear, the bracing piece is close to the equal rigid coupling of one end of second filter screen has a plurality of second spoilers, sealed covering is equipped with the motor that is used for providing power for the screw rod.

2. The filtering apparatus of claim 1, wherein the supporting rods comprise a first supporting rod fixedly connected to the transmission gear and a second supporting rod fixedly connected to the sealing cover, the first supporting rod has a polygonal connecting groove at an upper end thereof, the second supporting rod has a polygonal connecting block at a lower end thereof, the polygonal connecting block is insertable into the connecting groove, and a pulling rope connected to the first supporting rod is fixedly connected to an end of the second supporting rod facing the first supporting rod.

3. The filtering apparatus of claim 2, wherein the second support bar has a plurality of anti-slip grooves, the first filter screen has a plurality of functional sleeves slidably connected to the second support bar and engaged with the protective grooves, and a plurality of third spoilers are fixed to the functional sleeves.

4. The filtering apparatus of claim 1, wherein the first filter screen has a plurality of regulating protrusions for the first turbulator ring to be inserted.

5. The filtering device of claim 1, wherein the second filter screen is rotatably provided with a screw mounting seat, the turbulence bars are rotatably connected with the screw mounting seat, the upper end of the screw mounting seat is provided with a polygonal limiting groove, and the lower end of the screw is fixedly connected with a polygonal limiting post capable of being inserted into the limiting groove.

6. The filtration apparatus of claim 5, wherein the inner wall of the second filter is fixed with a functional groove for rolling the driving wheel, and the functional groove is provided with a plurality of contact protrusions for increasing friction force.

7. The filtering device for a biopharmaceutical reactor of claim 1, wherein a plurality of rubber hanging plates contacting an inner wall of the fermenter are fixedly connected to an outer wall of the first filter screen.

8. The filtration apparatus of claim 1 wherein said sealing cap is in fluid communication with a closable fill tube having a controlled valve disposed therein.

9. The filtration apparatus of claim 8 wherein said sealing cap is in fluid communication with a piston tube, said piston tube having a functional piston slidably disposed therein.

10. The filtration apparatus for a biopharmaceutical reactor of claim 9, wherein said sealing lid has a plurality of pulling lugs for facilitating lifting of said sealing lid.