CN114720442A - High-flux hair drug rapid detection instrument based on quantum dot fluorescence technology - Google Patents
High-flux hair drug rapid detection instrument based on quantum dot fluorescence technology Download PDFInfo
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- CN114720442A CN114720442A CN202210317040.3A CN202210317040A CN114720442A CN 114720442 A CN114720442 A CN 114720442A CN 202210317040 A CN202210317040 A CN 202210317040A CN 114720442 A CN114720442 A CN 114720442A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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Abstract
The invention discloses a high-flux hair drug rapid detection instrument based on a quantum dot fluorescence technology, which comprises a processor, a high-precision anti-interference electronic circuit, a fluorescence detector and a scanning component, wherein the processor is connected with the high-precision anti-interference electronic circuit; the scanning component is used for generating exciting light to a detected substance, the fluorescence detector is used for detecting fluorescence generated by the detected substance under the excitation of the exciting light and converting the fluorescence into an electric signal, and the high-precision anti-interference electronic circuit is used for transmitting the electric signal to the processor for processing. The invention can ensure that the maximum energy of exciting light reaches the scanning detection surface, improves the detection signal intensity, and can quickly perform quantitative detection on 3 kinds of drugs in the hair sample within 3 minutes. The equipment has small volume and light weight (less than or equal to 1 Kg). The kit can realize the rapid detection of novel psychoactive substances such as fentanyl, methcathinone, synthetic cannabinoid K2 and the like, has high sensitivity, and can reach the detection standard of 0.2ng/mg hair drug.
Description
Technical Field
The invention relates to the technical field of drug detection, in particular to a high-flux hair drug rapid detection instrument based on a quantum dot fluorescence technology.
Background
Currently, an effective rapid detection device and scheme for novel psychoactive substances such as fentanyl, methcathinone and synthetic cannabinoid K2 in hair drugs are still lacked, so how to realize rapid detection and identification of the novel psychoactive substances becomes a difficult problem and a dilemma for drug addicts to control in current drug abstinence work.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a high-flux hair drug rapid detection instrument based on a quantum dot fluorescence technology.
In order to achieve the purpose, the invention adopts the following technical scheme:
a high flux hair drug fast detecting instrument based on quantum dot fluorescence technology comprises a processor, a high-precision anti-interference electronic circuit, a fluorescence detector and a scanning component; the scanning component is used for generating exciting light to a detected substance, the fluorescence detector is used for detecting fluorescence generated by the detected substance under the excitation of the exciting light and converting the fluorescence into an electric signal, and the high-precision anti-interference electronic circuit is used for transmitting the electric signal to the processor for processing.
Furthermore, the scanning component comprises an LED, a constant current source driving circuit, a diaphragm and an optical filter; the high-performance constant current source driving circuit is used for supplying power to the LED, the diaphragm and the optical filter are both located on the light path of the LED, the diaphragm is used for restraining the light beam of the LED, and the optical filter is used for filtering out the light beam with the specified wavelength.
Furthermore, the high-precision anti-interference electronic circuit comprises an I/V conversion circuit, a filter circuit and an AD conversion chip; the I/V conversion circuit, the filter circuit and the AD conversion chip are sequentially connected, the I/V conversion circuit is connected to the fluorescence detector, and the AD conversion chip is connected to the processor.
The invention has the beneficial effects that: the invention can ensure that the maximum energy of exciting light reaches the scanning detection surface, improves the detection signal intensity, and can quickly perform quantitative detection on 3 kinds of drugs in the hair sample within 3 minutes. The equipment has small volume and light weight (less than or equal to 1 Kg). The kit can realize the rapid detection of novel psychoactive substances such as fentanyl, methcathinone, synthetic cannabinoid K2 and the like, has high sensitivity, and can reach the detection standard of 0.2ng/mg hair drug.
Drawings
Fig. 1 is a schematic structural diagram of a detection instrument in embodiment 1 of the present invention.
Fig. 2 is a schematic diagram of a principle of a scanning device in embodiment 1 of the present invention;
fig. 3 is a schematic diagram of a high-precision anti-interference electronic circuit according to embodiment 1 of the present invention.
Detailed Description
The present invention will be further described with reference to the accompanying drawings, and it should be noted that the present embodiment is based on the technical solution, and the detailed implementation and the specific operation process are provided, but the protection scope of the present invention is not limited to the present embodiment.
Example 1
The embodiment provides a high-flux hair drug rapid detection instrument based on a quantum dot fluorescence technology, which mainly comprises a processor, a high-precision anti-interference electronic circuit, a fluorescence detector 1 and a scanning component 2, as shown in fig. 1; the scanning component 2 is used for generating exciting light to a detected substance, the fluorescence detector is used for detecting fluorescence generated by the detected substance under the excitation of the exciting light and converting the fluorescence into an electric signal, and the high-precision anti-interference electronic circuit is used for transmitting the electric signal to the processor for processing.
As shown in fig. 2, the scanning device includes an LED, a constant current source driving circuit, a diaphragm, and an optical filter; the high-performance constant current source driving circuit is used for supplying power to the LED, the diaphragm and the optical filter are both located on the light path of the LED, the diaphragm is used for restraining the light beam of the LED, and the optical filter is used for filtering out the light beam with the specified wavelength.
In this embodiment, the LED light emitting diode adopts a high-stability LED light emitting diode with a narrow spectral bandwidth, a low temperature coefficient, and a small scattering angle, and is used as an excitation light source. The high-performance constant current source driving circuit supplies power to the LED, and further provides stability of a light source. The diaphragm reduces the scattering of the LED, and the optical effective detection area is accurately controlled to obtain high anti-interference capability. Filters are used to filter out the desired emission at a particular wavelength.
The high-precision anti-interference electronic circuit is suitable for an overall design structure, and the circuit is integrally embedded into the overall structure, so that the electromagnetic interference resistance of the equipment can be enhanced. In this embodiment, as shown in fig. 3, the high-precision anti-interference electronic circuit includes an I/V conversion circuit, a filter circuit, and an AD conversion chip; the I/V conversion circuit, the filter circuit and the AD conversion chip are sequentially connected, the I/V conversion circuit is connected to the fluorescence detector, and the AD conversion chip is connected to the processor. In the embodiment, the I/V conversion circuit is formed by connecting an ultra-low current noise operational amplifier and a high-precision resistor, and the filter circuit is used for filtering signal noise. The AD conversion chip is used for carrying out digital conversion, obtaining a measured value and inputting the measured value into the processor for processing and displaying.
Example 2
This embodiment provides an application example of the detecting apparatus described in embodiment 1. Firstly, opening sample collection tools such as a pair of taking-out scissors and a sample collection bag; collecting hair by using scissors, and simultaneously loading the hair into a lysate for lysis; the split hair was placed on a test card and tested using the test instrument described in example 1. The scanning component generates exciting light and emits the exciting light to the detection card, the fluorescence generated by the detected substance under the excitation of the exciting light is sent to the fluorescence detector, the fluorescence detector converts an optical signal into an electric signal, and the high-precision anti-interference electronic circuit transmits the electric signal to the processor for processing.
Various corresponding changes and modifications can be made by those skilled in the art based on the above technical solutions and concepts, and all such changes and modifications should be included in the protection scope of the present invention.
Claims (2)
1. A high flux hair drug fast detection instrument based on quantum dot fluorescence technology is characterized by comprising a processor, a high-precision anti-interference electronic circuit, a fluorescence detector and a scanning component; the scanning component is used for generating exciting light to a detected substance, the fluorescence detector is used for detecting fluorescence generated by the detected substance under the excitation of the exciting light and converting the fluorescence into an electric signal, and the high-precision anti-interference electronic circuit is used for transmitting the electric signal to the processor for processing; the scanning element comprises an LED, a constant current source driving circuit, a diaphragm and an optical filter; the high-performance constant current source driving circuit is used for supplying power to the LED, the diaphragm and the optical filter are both located on the light path of the LED, the diaphragm is used for restraining the light beam of the LED, and the optical filter is used for filtering out the light beam with the specified wavelength.
2. The apparatus according to claim 1, wherein said high precision interference rejection electronic circuit comprises an I/V conversion circuit, a filter circuit and an AD conversion chip; the I/V conversion circuit, the filter circuit and the AD conversion chip are sequentially connected, the I/V conversion circuit is connected to the fluorescence detector, and the AD conversion chip is connected to the processor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210317040.3A CN114720442A (en) | 2022-03-29 | 2022-03-29 | High-flux hair drug rapid detection instrument based on quantum dot fluorescence technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210317040.3A CN114720442A (en) | 2022-03-29 | 2022-03-29 | High-flux hair drug rapid detection instrument based on quantum dot fluorescence technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114720442A true CN114720442A (en) | 2022-07-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210317040.3A Pending CN114720442A (en) | 2022-03-29 | 2022-03-29 | High-flux hair drug rapid detection instrument based on quantum dot fluorescence technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114720442A (en) |
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2022
- 2022-03-29 CN CN202210317040.3A patent/CN114720442A/en active Pending
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