CN114717239A - High-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr - Google Patents

Abstract

The invention relates to a high-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710 Thr. The mutant does not destroy or inhibit the blood coagulation activity of FVIII, the specific blood coagulation activity is 1.6-2 times of that of a wild type, and the mutant is superior in stability; the mutant obviously improves the drug efficacy of FVIII and has good clinical application prospect.

Description

High-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr

Technical Field

The invention belongs to the field of hemophilia, and particularly relates to a blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr with high activity.

Background

Currently, the lifelong alternative treatment of FVIII is the only clinically effective treatment. Due to the fact that the content of FVIII in blood plasma is extremely low (100-200 ng/ml), the source of concentrated human FVIII is limited, potential virus transmission risks exist, and with the development of biotechnology, the genetically recombinant FVIII gradually replaces FVIII from blood plasma, and becomes a first choice preparation for replacement therapy. Fviii replacement therapy greatly improves the condition and quality of life of hemophiliacs.

Over time, the shortfalls of replacement therapy are increasingly significantly uncovered: first, induction of inhibitor production is considered to be the most serious complication of replacement therapy, with approximately 20% to 30% of hemophilia a patients developing fviii inhibitor during treatment, leading to reduced efficacy and even failure of replacement therapy; secondly, the F VIII has short half-life and frequent administration times: the half-life of the FVIII in vivo is only less than 12 hours, and in order to maintain the effective concentration of the blood plasma and achieve the purpose of preventing bleeding, the FVIII needs to be injected for 3 times every week; thirdly, the F VIII replacement therapy cost is high, the average cost of replacement therapy for severe hemophilia A patients per year reaches 10 million dollars, although the hemophilia is listed as major disease medical insurance in China at present, the reimbursement rate is also increased year by year, but the expensive drug cost still brings heavy economic burden to families and society. The heavy economic burden is the main reason that most severe hemophilia A patients in China are difficult to persist in long-term prevention and treatment. Gene therapy with HA is expected to solve the above problems, avoiding patients from life-long replacement therapy and the risk of inhibitor production, and HAs been well developed in recent years, but patients receiving this treatment have observed a decline in fviii expression over time, and some patients still need to be treated with replacement therapy to maintain fviii levels in vivo, and the success of gene therapy HAs previously solved the problem of maintaining stable expression of the introduced factor gene in vivo, while non-replacement therapy may possibly delay or at least reduce the exposure to exogenous fviii in the future, but replacement therapy will still be the mainstay of HA therapy.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a high-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr, the mutant does not destroy or inhibit the blood coagulation activity of FVIII, the specific blood coagulation activity is 1.6-2 times of that of a wild type, and the stability is more excellent; the mutant obviously improves the drug efficacy of the FVIII and has good clinical application prospect.

The invention provides a nucleic acid for coding a high-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710 Thr:

(1) hF VIII cDNA: the nucleotide sequence is shown in any one of SEQ ID NO 1-4;

or (2) BDD hF VIII-SQ: the nucleotide sequence is shown as any one of SEQ ID NO 5-8;

or (3) BDDhFVIII-N8: the nucleotide sequence is shown in any one of SEQ ID NO 9-12;

or (4) BDD hFVIII-SC: the nucleotide sequence is shown in any one of SEQ ID NO 13-16;

or (5) BDD hF VIII- Δ F: the nucleotide sequence is shown in any one of SEQ ID NO 17-20.

The invention also provides a mutant protein of the polypeptide variant Gly710Thr of the high-activity blood coagulation factor VIII or VIII a, the amino acid sequence is shown in any one of SEQ ID NO 21-29, and the 710th amino acid of the mutant is Thr instead of Gly of wild type VIII or VIII a. The amino acid sequence sequentially comprises the amino acid sequences of the corresponding mutant proteins of hFVIII cDNA, BDHFVIII-SQ, BDHFVIII-N8, BDHFVIII-SC and BDHFVIII-delta F and the amino acid sequences of the mutant proteins of BDHFVIII-V3, BDD human-cl rhFVIII, pFVIII and BDD pFVIII-OL.

The invention also provides a nucleic acid encoding the mutant protein, or a nucleic acid which has the same length as the encoding nucleic acid and is completely complementary with the encoding nucleic acid.

The invention also provides a carrier for expressing the mutant protein.

The invention also provides a preparation method of the mutant protein of the polypeptide variant Gly710Thr of the high-activity blood coagulation factor VIII or VIII a, which comprises the following steps:

BDD-hFVIII or full-length FVIII is taken as a template, a PCR site-directed mutagenesis method is used for introducing mutation sites into wild FVIII, Gly710 amino acid residues are replaced by Thr, and BDD-hFVIII or full-length FVIII eukaryotic expression plasmids which are correctly inserted into Gly710Thr mutation are screened after transformation.

The invention also provides application of the mutant protein coding nucleic acid of the high-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr, and the application of the nucleic acid in preparing gene therapy medicaments comprises the steps of connecting the nucleic acid with a promoter and a termination sequence, constructing an expression plasmid, a gene therapy virus or a non-viral vector and expressing the mutant protein.

The invention also provides application of the mutant protein of the high-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr in preparing a recombinant protein treatment medicament for hemophilia.

The invention also provides application of the mutant protein of the high-activity blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr, which is applied to preparing the mutant fusion protein of the blood coagulation factor VIII or VIII a polypeptide variant Gly710Thr and is used for preparing a recombinant protein treatment medicament for hemophilia.

The fusion protein is obtained by fusing one of human albumin, immunoglobulin Fc, transferrin or alpha 1 antitrypsin with the mutant protein of the polypeptide variant Gly710Thr mutant of the blood coagulation factor VIII or VIII a.

The nucleic acid or amino acid sequence pharmaceutical composition or gene therapy vector of the present invention is useful for preventing and/or treating diseases, wherein the diseases mainly include hemorrhagic diseases or hemorrhage due to various causes; among the most likely bleeding disorders are hemophilia a and B, i.e. bleeding disorders due to hereditary factor viii deficiency, and include hemophilia a and B in which inhibitory antibodies are produced, or acquired factor viii deficiency due to the production of inhibitors; and other hemorrhagic diseases using bypass preparations, such as neonatal coagulation disorders; severe liver disease; high risk surgery; traumatic blood loss; bone marrow transplantation; thrombocytopenia and platelet dysfunction; emergency reversal of oral anticoagulation; a deficiency in congenital factor viii; von willebrand disease, and acquired von willebrand disease caused by inhibitors of von willebrand factor, blood loss associated with extensive injury, cerebral hemorrhage, platelet dysfunction.

Advantageous effects

The mutant does not destroy or inhibit the blood coagulation activity of FVIII, the specific blood coagulation activity is 1.6-2 times of that of a wild type, and the mutant is superior in stability; the mutant obviously improves the drug efficacy of FVIII and has good clinical application prospect.

Drawings

FIG. 1 shows the time course detection of FVIII activity of BDD-hFVIII Gly710Thr mutant in the absence of FIXa.

FIG. 2 shows the time course detection of FVIII activity of BDD-hFVIII Gly710Thr mutant in the presence of FIXa.

Detailed Description

The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.

Example 1

A mutant protein of a polypeptide variant Gly710Thr of high-activity blood coagulation factor VIII or VIII a, the amino acid sequence of which is shown in any one of SEQ ID NO 21-29, and the 710th amino acid of the mutant is Thr instead of Gly of wild type VIII or VIII a. In this example, muteins of hFVIII cDNA were used as examples.

Expression and purification of FVIII Gly710Thr mutant

(1) Expression: site-directed mutagenesis kit (using QuikChange: (9))

II XL sitte-Directed Mutagenesis Kit, Agilent, USA), using human B-region deletion type blood coagulation VIII factor (BDD-hFVIII) as a template, introducing mutation sites into wild type FVIII by a PCR site-Directed Mutagenesis method, replacing 710Gly with 710Thr, digesting amplification products by Dpn I, then transforming (adding 5-10 microliter of mutation products digested by Dpn I into 100 microliter of competent bacteria), coating transformed bacteria on a plate containing 1/2000 ampicillin, and culturing overnight to obtain clone; selecting a single colony, inoculating the single colony to 5ml LB culture solution containing 1/2000 ampicillin, carrying out overnight strain amplification on a shaking table at the temperature of 37 ℃ at the speed of 250 rpm, extracting plasmid DNA for sequencing, and screening BDD-hF VIII eukaryotic expression plasmids which correctly insert Gly710Thr mutation.

(2) And (3) purification: and transfecting CHO cells by using wild BDD-hFVIII and the constructed BDD-hFVIII Gly710Thr expression plasmids, and establishing a blank vector control. After the stable high-expression clone cell strain is screened out, the clone cell strain is transferred into a selective serum-free culture solution for large-scale culture, and the FVIII secreted into the culture solution is purified by an immunoadsorption method (immunoadsorption gel VIII-Select, GE Healthcare, USA). The product was concentrated using Centricon Plus Ultrafiltration centrifuge tubes (MILLIPORE, USA).

Detection of blood coagulation Activity of FVIII Gly710Thr mutant

(1) Coenzyme Activity assay of FVIII Gly710Thr mutant (FXa production assay): the coactivator activity of FVIII is manifested as the ability of FIXa to assist in the cleavage of FX to FXa. The wild-type BDD-hFVIII is used as a control, and the FXa generation experiment is used for evaluating the coenzyme activity of the FVIII Gly710Thr mutant: thrombin acts on FVIII for 1min (FVIII: thrombin: 20:1) to activate FVIII to FVIII a, hirudin inactivates thrombin; 0.5nM of FVIIIa is taken, 20 mu M, FIXa40nM of PSPC phospholipid particles are added, mixed and incubated for 1min at 37 ℃, FX with different concentrations of 0nM, 20nM, 40nM, 60nM, 120nM, 240nM and the like is respectively added, reaction is carried out for 10min at 37 ℃, and EDTA stops the reaction; adding FXa specific chromogenic substrate S-2765, carrying out color comparison at the wavelength of 405nm, and measuring the generated FXa. Michaelis-Menten enzyme kinetic analysis was performed using graphpad prism software, and the enzyme kinetic constants Km, Kcat, and Vmax were calculated.

(2) Effect of fviii Gly710Thr mutant on fviii specific activity: the specific activity of FVIII represents the coagulation activity of FVIII per mg of protein. The activity of the purified BDD-hFVIII mutant and wild type was determined using a first-stage and a second-stage method (Chromogenissay) according to

SP4F VIII kit (Chromogenix, Italy) protocol. Protein quantification with enzyme-linked immunosorbent assay: the concentration of the sample was determined by sandwich ELISA using anti-C2 antibody GMA-8014 as the capture antibody, biotin-labeled anti-A2 antibody GMA-8016 as the detection antibody, and purified recombinant human FVIII as the standard. The specific activity of the FVIII mutant and the relative activity of the FVIII mutant relative to the wild type were calculated.

Effect of FVIII Gly710Thr mutants on FVIII stability

(1) Viii thermal stability test: the stability of the wild type FVIII was assessed by observing the degree of activity loss of the FVIII Gly710Thr mutant under high temperature conditions. Respectively taking 4nM of wild type FVIII and FVIII mutants, incubating at 55 ℃, respectively sampling at 0min, 10min, 20min, 30min and 40min after incubation, detecting residual FVIII activity by applying a chromogenic substrate method, and analyzing by graphpadprist software to obtain a one phase decay model fitting attenuation curve to obtain a half-life period.

(2) Fviia activity decay assay:

the time course of FVIII activity in the absence of FIXa: respectively taking 4nM of F VIII Gly710Thr and wild type BDD-hF VIII, inactivating thrombin by hirudin after 20nM activation of thrombin, adding FIXa40nM and PSPC 10 mu M, mixing, incubating at 23 ℃, respectively sampling at 0min, 5min, 10min, 15min and 20min after incubation, adding FX, detecting the FXa concentration of the sample according to an FXa generation test program, and indirectly determining the concentration of residual F VIII a.

Interval of FVIII activity in the presence of FIXa: the above procedure was repeated, and factor IXa40nM was added to the reaction before thrombin was added. Inactivating thrombin by hirudin after 20nM activation of thrombin, adding 10 μ M of PSPC, incubating at 23 ℃ after mixing, respectively sampling at 0min, 10min, 20min, 30min and 40min after incubation, adding FX, detecting FXa concentration of a sample by comparing with FXa generation test program, and indirectly determining the concentration of residual FVIIIa.

And thirdly, fitting an attenuation curve by using a one phase decay model of the graphpad prism to obtain a half-life period, and comparing the stability of the FVIIia.

4. Results of the experiment

(1) And (3) testing relative ratio of the BDD-hF VIII Gly710Thr mutant to activity:

transient transfection of plasmid into CHO cell, culturing for 48 hr, collecting culture liquid, taking supernatant for detection, detecting the activity of the mutant by APTT one-stage method, detecting the protein amount of the mutant by ELISA method, comparing with wild BDD-hF VIII, and obtaining the relative specific activity of the mutant primarily. The results show that: the relative specific activity of the BDD-hF VIII Gly710Thr mutant is 1.084 +/-0.004.

Screening cell strains stably expressed by the BDD-hFVIII Gly710Thr mutant for high-capacity cell culture, collecting culture solutions in 48h and 72h respectively, and extracting, purifying and concentrating at low temperature to obtain the target protein. And respectively detecting the activity of the mutant by a first-stage method and a second-stage method, detecting the protein amount of the mutant by an ELISA method, and comparing the protein amount with the wild BDD-hFVIII to calculate the relative specific activity of the mutant. The results show that: the relative ratio activity of the BDD-hFVIII Gly710Thr mutant in the first phase method is 2.07 +/-0.67, and the relative ratio activity in the second phase method is 1.62 +/-0.65.

(2) And (3) detecting the coenzyme activity and stability of the BDD-hFVIII Gly710Thr mutant:

the high-capacity cell culture product is adopted for detection, and the coenzyme activity and stability of the mutant are detected through FXa generation test, FVIII activity time-course test and the like, and the result shows that the mutant not only has the coenzyme performance and the thermal stability equivalent to those of a wild type but also shows better stability in the absence of FIXa under the same activity concentration.

The coenzyme action of the F VIII Gly710Thr mutant is detected by an FXa generation test. The results show that: after the FVIII Gly710 site is mutated into Thr, the coenzyme has the same coenzyme performance as the wild type.

② the coenzyme state and stability of the FVIII Gly710Thr mutant are detected by the activity time course of the FVIII in the absence of IXa. As shown in the results of fig. 1: in the reaction without FIXa, the half-life of the F VIII Gly710Thr mutant is 2 times of that of the wild type at 23 ℃, which indicates that the F VIII Gly710Thr mutant has better retention rate of A2 subunit and more excellent stability.

And thirdly, observing the influence of the FVIII mutant on the stability of the FVIII by detecting the time course of the FVIII activity in the presence of FIXa. As shown by the results in fig. 2: in the reaction containing FIXa, the half-life of the FVIII Gly710Thr mutant is equivalent to that of the wild type at 23 ℃.

And fourthly, BDD-hF VIII Gly710Thr mutant thermal stability detection: the activity of the FVIII Gly710Thr mutant and the wild-type BDD at 55 ℃ was attenuated by 50% for a comparable period of time, suggesting that both have similar thermostability at high temperature.

SEQUENCE LISTING

<110> first subsidiary Hospital of Guangxi medical university

<120> a highly active factor VIII or VIII a polypeptide variant Gly710Thr

<130> 1

<160> 29

<170> PatentIn version 3.3

<210> 1

<211> 7056

<212> DNA

<213> Artificial sequence

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gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct 5160

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg 5220

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acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc 5700

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ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc 5820

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga 5880

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat 5940

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt 6000

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt 6060

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt 6120

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga 6180

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc 6240

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt 6300

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt 6360

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga 6420

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac 6480

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact 6540

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag 6600

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc 6660

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct 6720

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca 6780

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc 6840

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag 6900

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta 6960

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg 7020

gaggttctgg gctgcgaggc acaggacctc tactag 7056

<210> 2

<211> 7056

<212> DNA

<213> Artificial sequence

<400> 2

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgacc tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340

ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa 2400

atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat 2460

gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca 2520

cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc 2580

catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag 2640

aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca 2700

tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca 2760

agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta 2820

tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa 2880

aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga 2940

aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct 3000

gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac 3060

aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta 3120

attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa 3180

gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta 3240

aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa 3300

gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc 3360

ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg 3420

caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag 3480

aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta 3540

ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat 3600

ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag 3660

gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag 3720

aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac 3780

ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca 3840

aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga 3900

aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca 3960

agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca 4020

ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc 4080

aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag 4140

aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct 4200

caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct 4260

atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat 4320

agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat 4380

aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc 4440

ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg 4500

aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat 4560

cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg 4620

gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct 4680

ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta 4740

ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa 4800

tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg 4860

aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa 4920

atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca 4980

gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa 5040

attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat 5100

gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct 5160

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg 5220

gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc 5280

tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca 5340

tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt 5400

ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa 5460

cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat 5520

catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt 5580

gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac 5640

acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc 5700

atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct 5760

ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc 5820

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga 5880

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat 5940

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt 6000

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt 6060

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt 6120

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga 6180

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc 6240

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt 6300

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt 6360

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga 6420

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac 6480

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact 6540

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag 6600

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc 6660

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct 6720

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca 6780

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc 6840

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag 6900

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta 6960

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg 7020

gaggttctgg gctgcgaggc acaggacctc tactag 7056

<210> 3

<211> 7056

<212> DNA

<213> Artificial sequence

<400> 3

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgaca tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340

ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa 2400

atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat 2460

gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca 2520

cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc 2580

catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag 2640

aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca 2700

tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca 2760

agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta 2820

tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa 2880

aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga 2940

aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct 3000

gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac 3060

aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta 3120

attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa 3180

gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta 3240

aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa 3300

gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc 3360

ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg 3420

caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag 3480

aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta 3540

ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat 3600

ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag 3660

gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag 3720

aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac 3780

ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca 3840

aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga 3900

aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca 3960

agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca 4020

ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc 4080

aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag 4140

aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct 4200

caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct 4260

atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat 4320

agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat 4380

aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc 4440

ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg 4500

aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat 4560

cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg 4620

gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct 4680

ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta 4740

ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa 4800

tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg 4860

aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa 4920

atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca 4980

gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa 5040

attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat 5100

gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct 5160

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg 5220

gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc 5280

tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca 5340

tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt 5400

ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa 5460

cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat 5520

catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt 5580

gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac 5640

acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc 5700

atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct 5760

ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc 5820

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga 5880

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat 5940

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt 6000

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt 6060

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt 6120

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga 6180

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc 6240

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt 6300

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt 6360

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga 6420

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac 6480

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact 6540

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag 6600

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc 6660

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct 6720

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca 6780

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc 6840

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag 6900

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta 6960

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg 7020

gaggttctgg gctgcgaggc acaggacctc tactag 7056

<210> 4

<211> 7056

<212> DNA

<213> Artificial sequence

<400> 4

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgacg tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340

ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa 2400

atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat 2460

gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca 2520

cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc 2580

catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag 2640

aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca 2700

tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca 2760

agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta 2820

tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa 2880

aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga 2940

aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct 3000

gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac 3060

aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta 3120

attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa 3180

gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta 3240

aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa 3300

gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc 3360

ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg 3420

caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag 3480

aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta 3540

ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat 3600

ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag 3660

gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag 3720

aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac 3780

ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca 3840

aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga 3900

aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca 3960

agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca 4020

ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc 4080

aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag 4140

aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct 4200

caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct 4260

atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat 4320

agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat 4380

aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc 4440

ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg 4500

aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat 4560

cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg 4620

gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct 4680

ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta 4740

ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa 4800

tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg 4860

aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa 4920

atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca 4980

gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa 5040

attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat 5100

gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct 5160

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg 5220

gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc 5280

tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca 5340

tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt 5400

ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa 5460

cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat 5520

catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt 5580

gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac 5640

acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc 5700

atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct 5760

ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc 5820

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga 5880

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat 5940

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt 6000

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt 6060

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt 6120

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga 6180

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc 6240

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt 6300

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt 6360

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga 6420

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac 6480

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact 6540

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag 6600

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc 6660

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct 6720

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca 6780

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc 6840

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag 6900

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta 6960

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg 7020

gaggttctgg gctgcgaggc acaggacctc tactag 7056

<210> 5

<211> 4374

<212> DNA

<213> Artificial sequence

<400> 5

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttact tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaagagg catcagcggg agatcacccg cacgaccctg 2340

cagtcggatc aggaggagat tgattacgac gacacgatca gtgtggagat gaagaaggag 2400

gacttcgaca tctacgacga agatgaaaac cagtcccctc ggtccttcca aaagaagacc 2460

cggcactact tcatcgccgc tgtggaacgc ctgtgggact atggaatgtc ttctagccct 2520

cacgttttga ggaaccgcgc ccagtcgggc agcgtgcccc agttcaagaa agtggtgttc 2580

caggagttca ccgacggctc cttcacccag ccactttacc ggggcgagct caatgaacat 2640

ctgggcctgc tgggacccta catcagggct gaggtggagg acaacatcat ggtgacattc 2700

cggaatcagg ccagcagacc atacagtttc tacagttcac tcatctccta cgaggaggac 2760

cagcgccagg gggctgaacc ccgtaagaac ttcgtgaagc caaacgaaac aaagacctac 2820

ttctggaagg tccagcacca catggcacct accaaggacg agttcgattg caaggcctgg 2880

gcctacttct ccgacgtgga cctggagaaa gatgtgcaca gcggcctgat tggccctctg 2940

ctggtgtgtc acacgaacac actcaaccct gcacacgggc ggcaggtcac tgtgcaggaa 3000

ttcgccctgt tctttaccat ctttgatgag acgaagtcct ggtatttcac cgaaaacatg 3060

gagaggaact gccgcgcacc ctgcaacatc cagatggaag atccgacatt caaggagaac 3120

taccggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct cgtgatggcc 3180

caagaccagc gtatccgctg gtatctgctg tcgatgggct ccaacgagaa catccatagt 3240

atccacttca gcgggcatgt cttcacggtg aggaaaaagg aggagtacaa gatggcactg 3300

tacaacctct atcccggcgt gttcgagacc gtggagatgc tgccctccaa ggccggcatc 3360

tggagagtgg aatgcctgat cggcgagcac ctccacgctg ggatgtccac gctgttcctc 3420

gtttacagca ataagtgcca gacccctctg ggcatggcga gcggccacat ccgcgacttc 3480

cagattacag ccagcggcca gtacggtcag tgggctccaa agctggcccg tctgcactac 3540

tccggatcca tcaacgcctg gtccaccaag gaaccgttct cctggatcaa agtagacctg 3600

ctagccccca tgatcattca cggcatcaag acacaaggcg cccgacagaa gttctcgagc 3660

ctctatatct cccagttcat catcatgtat agcctggacg gaaagaagtg gcagacttac 3720

cgcggaaact cgacagggac cctgatggta ttcttcggta acgtggacag ctccggaatc 3780

aagcacaaca tcttcaaccc acccattatc gcccgctaca tccgcctgca ccccactcac 3840

tatagcatta ggtccaccct gcgaatggag ctcatgggct gtgacctgaa cagctgtagc 3900

atgcccctcg gcatggagtc taaggcgatc tccgacgcac agataacggc atcatcctac 3960

tttaccaaca tgttcgctac ctggtccccc tccaaggccc gactccacct gcaagggaga 4020

tccaacgcct ggcggccaca ggtcaacaat cccaaggagt ggctgcaagt ggactttcag 4080

aaaactatga aagtcaccgg agtgaccaca cagggagtga agtctctgct gaccagcatg 4140

tacgtgaagg agttcctcat ctccagttcg caggatggcc accagtggac gttgttcttc 4200

caaaacggta aagtcaaagt cttccaaggg aaccaggaca gctttacacc cgtcgtgaac 4260

tccctggacc ccccgcttct cactagatac ctccgcatcc accctcagag ctgggtgcac 4320

cagattgccc tgcgcatgga ggttctgggg tgtgaagccc aggacctgta ctaa 4374

<210> 6

<211> 4374

<212> DNA

<213> Artificial sequence

<400> 6

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttacc tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaagagg catcagcggg agatcacccg cacgaccctg 2340

cagtcggatc aggaggagat tgattacgac gacacgatca gtgtggagat gaagaaggag 2400

gacttcgaca tctacgacga agatgaaaac cagtcccctc ggtccttcca aaagaagacc 2460

cggcactact tcatcgccgc tgtggaacgc ctgtgggact atggaatgtc ttctagccct 2520

cacgttttga ggaaccgcgc ccagtcgggc agcgtgcccc agttcaagaa agtggtgttc 2580

caggagttca ccgacggctc cttcacccag ccactttacc ggggcgagct caatgaacat 2640

ctgggcctgc tgggacccta catcagggct gaggtggagg acaacatcat ggtgacattc 2700

cggaatcagg ccagcagacc atacagtttc tacagttcac tcatctccta cgaggaggac 2760

cagcgccagg gggctgaacc ccgtaagaac ttcgtgaagc caaacgaaac aaagacctac 2820

ttctggaagg tccagcacca catggcacct accaaggacg agttcgattg caaggcctgg 2880

gcctacttct ccgacgtgga cctggagaaa gatgtgcaca gcggcctgat tggccctctg 2940

ctggtgtgtc acacgaacac actcaaccct gcacacgggc ggcaggtcac tgtgcaggaa 3000

ttcgccctgt tctttaccat ctttgatgag acgaagtcct ggtatttcac cgaaaacatg 3060

gagaggaact gccgcgcacc ctgcaacatc cagatggaag atccgacatt caaggagaac 3120

taccggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct cgtgatggcc 3180

caagaccagc gtatccgctg gtatctgctg tcgatgggct ccaacgagaa catccatagt 3240

atccacttca gcgggcatgt cttcacggtg aggaaaaagg aggagtacaa gatggcactg 3300

tacaacctct atcccggcgt gttcgagacc gtggagatgc tgccctccaa ggccggcatc 3360

tggagagtgg aatgcctgat cggcgagcac ctccacgctg ggatgtccac gctgttcctc 3420

gtttacagca ataagtgcca gacccctctg ggcatggcga gcggccacat ccgcgacttc 3480

cagattacag ccagcggcca gtacggtcag tgggctccaa agctggcccg tctgcactac 3540

tccggatcca tcaacgcctg gtccaccaag gaaccgttct cctggatcaa agtagacctg 3600

ctagccccca tgatcattca cggcatcaag acacaaggcg cccgacagaa gttctcgagc 3660

ctctatatct cccagttcat catcatgtat agcctggacg gaaagaagtg gcagacttac 3720

cgcggaaact cgacagggac cctgatggta ttcttcggta acgtggacag ctccggaatc 3780

aagcacaaca tcttcaaccc acccattatc gcccgctaca tccgcctgca ccccactcac 3840

tatagcatta ggtccaccct gcgaatggag ctcatgggct gtgacctgaa cagctgtagc 3900

atgcccctcg gcatggagtc taaggcgatc tccgacgcac agataacggc atcatcctac 3960

tttaccaaca tgttcgctac ctggtccccc tccaaggccc gactccacct gcaagggaga 4020

tccaacgcct ggcggccaca ggtcaacaat cccaaggagt ggctgcaagt ggactttcag 4080

aaaactatga aagtcaccgg agtgaccaca cagggagtga agtctctgct gaccagcatg 4140

tacgtgaagg agttcctcat ctccagttcg caggatggcc accagtggac gttgttcttc 4200

caaaacggta aagtcaaagt cttccaaggg aaccaggaca gctttacacc cgtcgtgaac 4260

tccctggacc ccccgcttct cactagatac ctccgcatcc accctcagag ctgggtgcac 4320

cagattgccc tgcgcatgga ggttctgggg tgtgaagccc aggacctgta ctaa 4374

<210> 7

<211> 4374

<212> DNA

<213> Artificial sequence

<400> 7

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttaca tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaagagg catcagcggg agatcacccg cacgaccctg 2340

cagtcggatc aggaggagat tgattacgac gacacgatca gtgtggagat gaagaaggag 2400

gacttcgaca tctacgacga agatgaaaac cagtcccctc ggtccttcca aaagaagacc 2460

cggcactact tcatcgccgc tgtggaacgc ctgtgggact atggaatgtc ttctagccct 2520

cacgttttga ggaaccgcgc ccagtcgggc agcgtgcccc agttcaagaa agtggtgttc 2580

caggagttca ccgacggctc cttcacccag ccactttacc ggggcgagct caatgaacat 2640

ctgggcctgc tgggacccta catcagggct gaggtggagg acaacatcat ggtgacattc 2700

cggaatcagg ccagcagacc atacagtttc tacagttcac tcatctccta cgaggaggac 2760

cagcgccagg gggctgaacc ccgtaagaac ttcgtgaagc caaacgaaac aaagacctac 2820

ttctggaagg tccagcacca catggcacct accaaggacg agttcgattg caaggcctgg 2880

gcctacttct ccgacgtgga cctggagaaa gatgtgcaca gcggcctgat tggccctctg 2940

ctggtgtgtc acacgaacac actcaaccct gcacacgggc ggcaggtcac tgtgcaggaa 3000

ttcgccctgt tctttaccat ctttgatgag acgaagtcct ggtatttcac cgaaaacatg 3060

gagaggaact gccgcgcacc ctgcaacatc cagatggaag atccgacatt caaggagaac 3120

taccggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct cgtgatggcc 3180

caagaccagc gtatccgctg gtatctgctg tcgatgggct ccaacgagaa catccatagt 3240

atccacttca gcgggcatgt cttcacggtg aggaaaaagg aggagtacaa gatggcactg 3300

tacaacctct atcccggcgt gttcgagacc gtggagatgc tgccctccaa ggccggcatc 3360

tggagagtgg aatgcctgat cggcgagcac ctccacgctg ggatgtccac gctgttcctc 3420

gtttacagca ataagtgcca gacccctctg ggcatggcga gcggccacat ccgcgacttc 3480

cagattacag ccagcggcca gtacggtcag tgggctccaa agctggcccg tctgcactac 3540

tccggatcca tcaacgcctg gtccaccaag gaaccgttct cctggatcaa agtagacctg 3600

ctagccccca tgatcattca cggcatcaag acacaaggcg cccgacagaa gttctcgagc 3660

ctctatatct cccagttcat catcatgtat agcctggacg gaaagaagtg gcagacttac 3720

cgcggaaact cgacagggac cctgatggta ttcttcggta acgtggacag ctccggaatc 3780

aagcacaaca tcttcaaccc acccattatc gcccgctaca tccgcctgca ccccactcac 3840

tatagcatta ggtccaccct gcgaatggag ctcatgggct gtgacctgaa cagctgtagc 3900

atgcccctcg gcatggagtc taaggcgatc tccgacgcac agataacggc atcatcctac 3960

tttaccaaca tgttcgctac ctggtccccc tccaaggccc gactccacct gcaagggaga 4020

tccaacgcct ggcggccaca ggtcaacaat cccaaggagt ggctgcaagt ggactttcag 4080

aaaactatga aagtcaccgg agtgaccaca cagggagtga agtctctgct gaccagcatg 4140

tacgtgaagg agttcctcat ctccagttcg caggatggcc accagtggac gttgttcttc 4200

caaaacggta aagtcaaagt cttccaaggg aaccaggaca gctttacacc cgtcgtgaac 4260

tccctggacc ccccgcttct cactagatac ctccgcatcc accctcagag ctgggtgcac 4320

cagattgccc tgcgcatgga ggttctgggg tgtgaagccc aggacctgta ctaa 4374

<210> 8

<211> 4374

<212> DNA

<213> Artificial sequence

<400> 8

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttacg tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaagagg catcagcggg agatcacccg cacgaccctg 2340

cagtcggatc aggaggagat tgattacgac gacacgatca gtgtggagat gaagaaggag 2400

gacttcgaca tctacgacga agatgaaaac cagtcccctc ggtccttcca aaagaagacc 2460

cggcactact tcatcgccgc tgtggaacgc ctgtgggact atggaatgtc ttctagccct 2520

cacgttttga ggaaccgcgc ccagtcgggc agcgtgcccc agttcaagaa agtggtgttc 2580

caggagttca ccgacggctc cttcacccag ccactttacc ggggcgagct caatgaacat 2640

ctgggcctgc tgggacccta catcagggct gaggtggagg acaacatcat ggtgacattc 2700

cggaatcagg ccagcagacc atacagtttc tacagttcac tcatctccta cgaggaggac 2760

cagcgccagg gggctgaacc ccgtaagaac ttcgtgaagc caaacgaaac aaagacctac 2820

ttctggaagg tccagcacca catggcacct accaaggacg agttcgattg caaggcctgg 2880

gcctacttct ccgacgtgga cctggagaaa gatgtgcaca gcggcctgat tggccctctg 2940

ctggtgtgtc acacgaacac actcaaccct gcacacgggc ggcaggtcac tgtgcaggaa 3000

ttcgccctgt tctttaccat ctttgatgag acgaagtcct ggtatttcac cgaaaacatg 3060

gagaggaact gccgcgcacc ctgcaacatc cagatggaag atccgacatt caaggagaac 3120

taccggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct cgtgatggcc 3180

caagaccagc gtatccgctg gtatctgctg tcgatgggct ccaacgagaa catccatagt 3240

atccacttca gcgggcatgt cttcacggtg aggaaaaagg aggagtacaa gatggcactg 3300

tacaacctct atcccggcgt gttcgagacc gtggagatgc tgccctccaa ggccggcatc 3360

tggagagtgg aatgcctgat cggcgagcac ctccacgctg ggatgtccac gctgttcctc 3420

gtttacagca ataagtgcca gacccctctg ggcatggcga gcggccacat ccgcgacttc 3480

cagattacag ccagcggcca gtacggtcag tgggctccaa agctggcccg tctgcactac 3540

tccggatcca tcaacgcctg gtccaccaag gaaccgttct cctggatcaa agtagacctg 3600

ctagccccca tgatcattca cggcatcaag acacaaggcg cccgacagaa gttctcgagc 3660

ctctatatct cccagttcat catcatgtat agcctggacg gaaagaagtg gcagacttac 3720

cgcggaaact cgacagggac cctgatggta ttcttcggta acgtggacag ctccggaatc 3780

aagcacaaca tcttcaaccc acccattatc gcccgctaca tccgcctgca ccccactcac 3840

tatagcatta ggtccaccct gcgaatggag ctcatgggct gtgacctgaa cagctgtagc 3900

atgcccctcg gcatggagtc taaggcgatc tccgacgcac agataacggc atcatcctac 3960

tttaccaaca tgttcgctac ctggtccccc tccaaggccc gactccacct gcaagggaga 4020

tccaacgcct ggcggccaca ggtcaacaat cccaaggagt ggctgcaagt ggactttcag 4080

aaaactatga aagtcaccgg agtgaccaca cagggagtga agtctctgct gaccagcatg 4140

tacgtgaagg agttcctcat ctccagttcg caggatggcc accagtggac gttgttcttc 4200

caaaacggta aagtcaaagt cttccaaggg aaccaggaca gctttacacc cgtcgtgaac 4260

tccctggacc ccccgcttct cactagatac ctccgcatcc accctcagag ctgggtgcac 4320

cagattgccc tgcgcatgga ggttctgggg tgtgaagccc aggacctgta ctaa 4374

<210> 9

<211> 4395

<212> DNA

<213> Artificial sequence

<400> 9

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgact tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca cccttctcaa aacccaccag tcttgaaacg ccatcaacgg 2340

gaaataactc gtactactct tcagtcagat caagaggaaa ttgactatga tgataccata 2400

tcagttgaaa tgaagaagga agattttgac atttatgatg aggatgaaaa tcagagcccc 2460

cgcagctttc aaaagaaaac acgacactat tttattgctg cagtggagag gctctgggat 2520

tatgggatga gtagctcccc acatgttcta agaaacaggg ctcagagtgg cagtgtccct 2580

cagttcaaga aagttgtttt ccaggaattt actgatggct cctttactca gcccttatac 2640

cgtggagaac taaatgaaca tttgggactc ctggggccat atataagagc agaagttgaa 2700

gataatatca tggtaacttt cagaaatcag gcctctcgtc cctattcctt ctattctagc 2760

cttatttctt atgaggaaga tcagaggcaa ggagcagaac ctagaaaaaa ctttgtcaag 2820

cctaatgaaa ccaaaactta cttttggaaa gtgcaacatc atatggcacc cactaaagat 2880

gagtttgact gcaaagcctg ggcttatttc tctgatgttg acctggaaaa agatgtgcac 2940

tcaggcctga ttggacccct tctggtctgc cacactaaca cactgaaccc tgctcatggg 3000

agacaagtga cagtacagga atttgctctg tttttcacca tctttgatga gaccaaaagc 3060

tggtacttca ctgaaaatat ggaaagaaac tgcagggctc cctgcaatat ccagatggaa 3120

gatcccactt ttaaagagaa ttatcgcttc catgcaatca atggctacat aatggataca 3180

ctacctggct tagtaatggc tcaggatcaa aggattcgat ggtatctgct cagcatgggc 3240

agcaatgaaa acatccattc tattcatttc agtggacatg tgttcactgt acgaaaaaaa 3300

gaggagtata aaatggcact gtacaatctc tatccaggtg tttttgagac agtggaaatg 3360

ttaccatcca aagctggaat ttggcgggtg gaatgcctta ttggcgagca tctacatgct 3420

gggatgagca cactttttct ggtgtacagc aataagtgtc agactcccct gggaatggct 3480

tctggacaca ttagagattt tcagattaca gcttcaggac aatatggaca gtgggcccca 3540

aagctggcca gacttcatta ttccggatca atcaatgcct ggagcaccaa ggagcccttt 3600

tcttggatca aggtggatct gttggcacca atgattattc acggcatcaa gacccagggt 3660

gcccgtcaga agttctccag cctctacatc tctcagttta tcatcatgta tagtcttgat 3720

gggaagaagt ggcagactta tcgaggaaat tccactggaa ccttaatggt cttctttggc 3780

aatgtggatt catctgggat aaaacacaat atttttaacc ctccaattat tgctcgatac 3840

atccgtttgc acccaactca ttatagcatt cgcagcactc ttcgcatgga gttgatgggc 3900

tgtgatttaa atagttgcag catgccattg ggaatggaga gtaaagcaat atcagatgca 3960

cagattactg cttcatccta ctttaccaat atgtttgcca cctggtctcc ttcaaaagct 4020

cgacttcacc tccaagggag gagtaatgcc tggagacctc aggtgaataa tccaaaagag 4080

tggctgcaag tggacttcca gaagacaatg aaagtcacag gagtaactac tcagggagta 4140

aaatctctgc ttaccagcat gtatgtgaag gagttcctca tctccagcag tcaagatggc 4200

catcagtgga ctctcttttt tcagaatggc aaagtaaagg tttttcaggg aaatcaagac 4260

tccttcacac ctgtggtgaa ctctctagac ccaccgttac tgactcgcta ccttcgaatt 4320

cacccccaga gttgggtgca ccagattgcc ctgaggatgg aggttctggg ctgcgaggca 4380

caggacctct actag 4395

<210> 10

<211> 4395

<212> DNA

<213> Artificial sequence

<400> 10

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgacc tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca cccttctcaa aacccaccag tcttgaaacg ccatcaacgg 2340

gaaataactc gtactactct tcagtcagat caagaggaaa ttgactatga tgataccata 2400

tcagttgaaa tgaagaagga agattttgac atttatgatg aggatgaaaa tcagagcccc 2460

cgcagctttc aaaagaaaac acgacactat tttattgctg cagtggagag gctctgggat 2520

tatgggatga gtagctcccc acatgttcta agaaacaggg ctcagagtgg cagtgtccct 2580

cagttcaaga aagttgtttt ccaggaattt actgatggct cctttactca gcccttatac 2640

cgtggagaac taaatgaaca tttgggactc ctggggccat atataagagc agaagttgaa 2700

gataatatca tggtaacttt cagaaatcag gcctctcgtc cctattcctt ctattctagc 2760

cttatttctt atgaggaaga tcagaggcaa ggagcagaac ctagaaaaaa ctttgtcaag 2820

cctaatgaaa ccaaaactta cttttggaaa gtgcaacatc atatggcacc cactaaagat 2880

gagtttgact gcaaagcctg ggcttatttc tctgatgttg acctggaaaa agatgtgcac 2940

tcaggcctga ttggacccct tctggtctgc cacactaaca cactgaaccc tgctcatggg 3000

agacaagtga cagtacagga atttgctctg tttttcacca tctttgatga gaccaaaagc 3060

tggtacttca ctgaaaatat ggaaagaaac tgcagggctc cctgcaatat ccagatggaa 3120

gatcccactt ttaaagagaa ttatcgcttc catgcaatca atggctacat aatggataca 3180

ctacctggct tagtaatggc tcaggatcaa aggattcgat ggtatctgct cagcatgggc 3240

agcaatgaaa acatccattc tattcatttc agtggacatg tgttcactgt acgaaaaaaa 3300

gaggagtata aaatggcact gtacaatctc tatccaggtg tttttgagac agtggaaatg 3360

ttaccatcca aagctggaat ttggcgggtg gaatgcctta ttggcgagca tctacatgct 3420

gggatgagca cactttttct ggtgtacagc aataagtgtc agactcccct gggaatggct 3480

tctggacaca ttagagattt tcagattaca gcttcaggac aatatggaca gtgggcccca 3540

aagctggcca gacttcatta ttccggatca atcaatgcct ggagcaccaa ggagcccttt 3600

tcttggatca aggtggatct gttggcacca atgattattc acggcatcaa gacccagggt 3660

gcccgtcaga agttctccag cctctacatc tctcagttta tcatcatgta tagtcttgat 3720

gggaagaagt ggcagactta tcgaggaaat tccactggaa ccttaatggt cttctttggc 3780

aatgtggatt catctgggat aaaacacaat atttttaacc ctccaattat tgctcgatac 3840

atccgtttgc acccaactca ttatagcatt cgcagcactc ttcgcatgga gttgatgggc 3900

tgtgatttaa atagttgcag catgccattg ggaatggaga gtaaagcaat atcagatgca 3960

cagattactg cttcatccta ctttaccaat atgtttgcca cctggtctcc ttcaaaagct 4020

cgacttcacc tccaagggag gagtaatgcc tggagacctc aggtgaataa tccaaaagag 4080

tggctgcaag tggacttcca gaagacaatg aaagtcacag gagtaactac tcagggagta 4140

aaatctctgc ttaccagcat gtatgtgaag gagttcctca tctccagcag tcaagatggc 4200

catcagtgga ctctcttttt tcagaatggc aaagtaaagg tttttcaggg aaatcaagac 4260

tccttcacac ctgtggtgaa ctctctagac ccaccgttac tgactcgcta ccttcgaatt 4320

cacccccaga gttgggtgca ccagattgcc ctgaggatgg aggttctggg ctgcgaggca 4380

caggacctct actag 4395

<210> 11

<211> 4395

<212> DNA

<213> Artificial sequence

<400> 11

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgaca tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca cccttctcaa aacccaccag tcttgaaacg ccatcaacgg 2340

gaaataactc gtactactct tcagtcagat caagaggaaa ttgactatga tgataccata 2400

tcagttgaaa tgaagaagga agattttgac atttatgatg aggatgaaaa tcagagcccc 2460

cgcagctttc aaaagaaaac acgacactat tttattgctg cagtggagag gctctgggat 2520

tatgggatga gtagctcccc acatgttcta agaaacaggg ctcagagtgg cagtgtccct 2580

cagttcaaga aagttgtttt ccaggaattt actgatggct cctttactca gcccttatac 2640

cgtggagaac taaatgaaca tttgggactc ctggggccat atataagagc agaagttgaa 2700

gataatatca tggtaacttt cagaaatcag gcctctcgtc cctattcctt ctattctagc 2760

cttatttctt atgaggaaga tcagaggcaa ggagcagaac ctagaaaaaa ctttgtcaag 2820

cctaatgaaa ccaaaactta cttttggaaa gtgcaacatc atatggcacc cactaaagat 2880

gagtttgact gcaaagcctg ggcttatttc tctgatgttg acctggaaaa agatgtgcac 2940

tcaggcctga ttggacccct tctggtctgc cacactaaca cactgaaccc tgctcatggg 3000

agacaagtga cagtacagga atttgctctg tttttcacca tctttgatga gaccaaaagc 3060

tggtacttca ctgaaaatat ggaaagaaac tgcagggctc cctgcaatat ccagatggaa 3120

gatcccactt ttaaagagaa ttatcgcttc catgcaatca atggctacat aatggataca 3180

ctacctggct tagtaatggc tcaggatcaa aggattcgat ggtatctgct cagcatgggc 3240

agcaatgaaa acatccattc tattcatttc agtggacatg tgttcactgt acgaaaaaaa 3300

gaggagtata aaatggcact gtacaatctc tatccaggtg tttttgagac agtggaaatg 3360

ttaccatcca aagctggaat ttggcgggtg gaatgcctta ttggcgagca tctacatgct 3420

gggatgagca cactttttct ggtgtacagc aataagtgtc agactcccct gggaatggct 3480

tctggacaca ttagagattt tcagattaca gcttcaggac aatatggaca gtgggcccca 3540

aagctggcca gacttcatta ttccggatca atcaatgcct ggagcaccaa ggagcccttt 3600

tcttggatca aggtggatct gttggcacca atgattattc acggcatcaa gacccagggt 3660

gcccgtcaga agttctccag cctctacatc tctcagttta tcatcatgta tagtcttgat 3720

gggaagaagt ggcagactta tcgaggaaat tccactggaa ccttaatggt cttctttggc 3780

aatgtggatt catctgggat aaaacacaat atttttaacc ctccaattat tgctcgatac 3840

atccgtttgc acccaactca ttatagcatt cgcagcactc ttcgcatgga gttgatgggc 3900

tgtgatttaa atagttgcag catgccattg ggaatggaga gtaaagcaat atcagatgca 3960

cagattactg cttcatccta ctttaccaat atgtttgcca cctggtctcc ttcaaaagct 4020

cgacttcacc tccaagggag gagtaatgcc tggagacctc aggtgaataa tccaaaagag 4080

tggctgcaag tggacttcca gaagacaatg aaagtcacag gagtaactac tcagggagta 4140

aaatctctgc ttaccagcat gtatgtgaag gagttcctca tctccagcag tcaagatggc 4200

catcagtgga ctctcttttt tcagaatggc aaagtaaagg tttttcaggg aaatcaagac 4260

tccttcacac ctgtggtgaa ctctctagac ccaccgttac tgactcgcta ccttcgaatt 4320

cacccccaga gttgggtgca ccagattgcc ctgaggatgg aggttctggg ctgcgaggca 4380

caggacctct actag 4395

<210> 12

<211> 4395

<212> DNA

<213> Artificial sequence

<400> 12

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgacg tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca cccttctcaa aacccaccag tcttgaaacg ccatcaacgg 2340

gaaataactc gtactactct tcagtcagat caagaggaaa ttgactatga tgataccata 2400

tcagttgaaa tgaagaagga agattttgac atttatgatg aggatgaaaa tcagagcccc 2460

cgcagctttc aaaagaaaac acgacactat tttattgctg cagtggagag gctctgggat 2520

tatgggatga gtagctcccc acatgttcta agaaacaggg ctcagagtgg cagtgtccct 2580

cagttcaaga aagttgtttt ccaggaattt actgatggct cctttactca gcccttatac 2640

cgtggagaac taaatgaaca tttgggactc ctggggccat atataagagc agaagttgaa 2700

gataatatca tggtaacttt cagaaatcag gcctctcgtc cctattcctt ctattctagc 2760

cttatttctt atgaggaaga tcagaggcaa ggagcagaac ctagaaaaaa ctttgtcaag 2820

cctaatgaaa ccaaaactta cttttggaaa gtgcaacatc atatggcacc cactaaagat 2880

gagtttgact gcaaagcctg ggcttatttc tctgatgttg acctggaaaa agatgtgcac 2940

tcaggcctga ttggacccct tctggtctgc cacactaaca cactgaaccc tgctcatggg 3000

agacaagtga cagtacagga atttgctctg tttttcacca tctttgatga gaccaaaagc 3060

tggtacttca ctgaaaatat ggaaagaaac tgcagggctc cctgcaatat ccagatggaa 3120

gatcccactt ttaaagagaa ttatcgcttc catgcaatca atggctacat aatggataca 3180

ctacctggct tagtaatggc tcaggatcaa aggattcgat ggtatctgct cagcatgggc 3240

agcaatgaaa acatccattc tattcatttc agtggacatg tgttcactgt acgaaaaaaa 3300

gaggagtata aaatggcact gtacaatctc tatccaggtg tttttgagac agtggaaatg 3360

ttaccatcca aagctggaat ttggcgggtg gaatgcctta ttggcgagca tctacatgct 3420

gggatgagca cactttttct ggtgtacagc aataagtgtc agactcccct gggaatggct 3480

tctggacaca ttagagattt tcagattaca gcttcaggac aatatggaca gtgggcccca 3540

aagctggcca gacttcatta ttccggatca atcaatgcct ggagcaccaa ggagcccttt 3600

tcttggatca aggtggatct gttggcacca atgattattc acggcatcaa gacccagggt 3660

gcccgtcaga agttctccag cctctacatc tctcagttta tcatcatgta tagtcttgat 3720

gggaagaagt ggcagactta tcgaggaaat tccactggaa ccttaatggt cttctttggc 3780

aatgtggatt catctgggat aaaacacaat atttttaacc ctccaattat tgctcgatac 3840

atccgtttgc acccaactca ttatagcatt cgcagcactc ttcgcatgga gttgatgggc 3900

tgtgatttaa atagttgcag catgccattg ggaatggaga gtaaagcaat atcagatgca 3960

cagattactg cttcatccta ctttaccaat atgtttgcca cctggtctcc ttcaaaagct 4020

cgacttcacc tccaagggag gagtaatgcc tggagacctc aggtgaataa tccaaaagag 4080

tggctgcaag tggacttcca gaagacaatg aaagtcacag gagtaactac tcagggagta 4140

aaatctctgc ttaccagcat gtatgtgaag gagttcctca tctccagcag tcaagatggc 4200

catcagtgga ctctcttttt tcagaatggc aaagtaaagg tttttcaggg aaatcaagac 4260

tccttcacac ctgtggtgaa ctctctagac ccaccgttac tgactcgcta ccttcgaatt 4320

cacccccaga gttgggtgca ccagattgcc ctgaggatgg aggttctggg ctgcgaggca 4380

caggacctct actag 4395

<210> 13

<211> 4392

<212> DNA

<213> Artificial sequence

<400> 13

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgact tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340

ccagaaaata ctactcttca gtcagatcaa gaggaaattg actatgatga taccatatca 2400

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc 2460

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat 2520

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag 2580

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt 2640

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat 2700

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt 2760

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct 2820

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag 2880

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca 2940

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga 3000

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg 3060

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat 3120

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta 3180

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc 3240

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag 3300

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta 3360

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg 3420

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct 3480

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag 3540

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct 3600

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc 3660

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg 3720

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat 3780

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc 3840

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt 3900

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag 3960

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga 4020

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg 4080

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa 4140

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat 4200

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc 4260

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac 4320

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag 4380

gacctctact ag 4392

<210> 14

<211> 4392

<212> DNA

<213> Artificial sequence

<400> 14

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgacc tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340

ccagaaaata ctactcttca gtcagatcaa gaggaaattg actatgatga taccatatca 2400

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc 2460

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat 2520

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag 2580

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt 2640

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat 2700

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt 2760

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct 2820

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag 2880

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca 2940

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga 3000

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg 3060

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat 3120

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta 3180

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc 3240

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag 3300

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta 3360

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg 3420

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct 3480

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag 3540

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct 3600

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc 3660

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg 3720

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat 3780

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc 3840

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt 3900

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag 3960

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga 4020

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg 4080

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa 4140

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat 4200

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc 4260

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac 4320

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag 4380

gacctctact ag 4392

<210> 15

<211> 4392

<212> DNA

<213> Artificial sequence

<400> 15

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgaca tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340

ccagaaaata ctactcttca gtcagatcaa gaggaaattg actatgatga taccatatca 2400

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc 2460

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat 2520

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag 2580

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt 2640

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat 2700

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt 2760

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct 2820

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag 2880

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca 2940

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga 3000

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg 3060

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat 3120

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta 3180

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc 3240

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag 3300

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta 3360

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg 3420

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct 3480

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag 3540

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct 3600

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc 3660

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg 3720

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat 3780

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc 3840

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt 3900

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag 3960

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga 4020

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg 4080

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa 4140

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat 4200

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc 4260

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac 4320

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag 4380

gacctctact ag 4392

<210> 16

<211> 4392

<212> DNA

<213> Artificial sequence

<400> 16

atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100

atggaaaacc caggtctatg gattctgacg tgccacaact cagactttcg gaacagaggc 2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340

ccagaaaata ctactcttca gtcagatcaa gaggaaattg actatgatga taccatatca 2400

gttgaaatga agaaggaaga ttttgacatt tatgatgagg atgaaaatca gagcccccgc 2460

agctttcaaa agaaaacacg acactatttt attgctgcag tggagaggct ctgggattat 2520

gggatgagta gctccccaca tgttctaaga aacagggctc agagtggcag tgtccctcag 2580

ttcaagaaag ttgttttcca ggaatttact gatggctcct ttactcagcc cttataccgt 2640

ggagaactaa atgaacattt gggactcctg gggccatata taagagcaga agttgaagat 2700

aatatcatgg taactttcag aaatcaggcc tctcgtccct attccttcta ttctagcctt 2760

atttcttatg aggaagatca gaggcaagga gcagaaccta gaaaaaactt tgtcaagcct 2820

aatgaaacca aaacttactt ttggaaagtg caacatcata tggcacccac taaagatgag 2880

tttgactgca aagcctgggc ttatttctct gatgttgacc tggaaaaaga tgtgcactca 2940

ggcctgattg gaccccttct ggtctgccac actaacacac tgaaccctgc tcatgggaga 3000

caagtgacag tacaggaatt tgctctgttt ttcaccatct ttgatgagac caaaagctgg 3060

tacttcactg aaaatatgga aagaaactgc agggctccct gcaatatcca gatggaagat 3120

cccactttta aagagaatta tcgcttccat gcaatcaatg gctacataat ggatacacta 3180

cctggcttag taatggctca ggatcaaagg attcgatggt atctgctcag catgggcagc 3240

aatgaaaaca tccattctat tcatttcagt ggacatgtgt tcactgtacg aaaaaaagag 3300

gagtataaaa tggcactgta caatctctat ccaggtgttt ttgagacagt ggaaatgtta 3360

ccatccaaag ctggaatttg gcgggtggaa tgccttattg gcgagcatct acatgctggg 3420

atgagcacac tttttctggt gtacagcaat aagtgtcaga ctcccctggg aatggcttct 3480

ggacacatta gagattttca gattacagct tcaggacaat atggacagtg ggccccaaag 3540

ctggccagac ttcattattc cggatcaatc aatgcctgga gcaccaagga gcccttttct 3600

tggatcaagg tggatctgtt ggcaccaatg attattcacg gcatcaagac ccagggtgcc 3660

cgtcagaagt tctccagcct ctacatctct cagtttatca tcatgtatag tcttgatggg 3720

aagaagtggc agacttatcg aggaaattcc actggaacct taatggtctt ctttggcaat 3780

gtggattcat ctgggataaa acacaatatt tttaaccctc caattattgc tcgatacatc 3840

cgtttgcacc caactcatta tagcattcgc agcactcttc gcatggagtt gatgggctgt 3900

gatttaaata gttgcagcat gccattggga atggagagta aagcaatatc agatgcacag 3960

attactgctt catcctactt taccaatatg tttgccacct ggtctccttc aaaagctcga 4020

cttcacctcc aagggaggag taatgcctgg agacctcagg tgaataatcc aaaagagtgg 4080

ctgcaagtgg acttccagaa gacaatgaaa gtcacaggag taactactca gggagtaaaa 4140

tctctgctta ccagcatgta tgtgaaggag ttcctcatct ccagcagtca agatggccat 4200

cagtggactc tcttttttca gaatggcaaa gtaaaggttt ttcagggaaa tcaagactcc 4260

ttcacacctg tggtgaactc tctagaccca ccgttactga ctcgctacct tcgaattcac 4320

ccccagagtt gggtgcacca gattgccctg aggatggagg ttctgggctg cgaggcacag 4380

gacctctact ag 4392

<210> 17

<211> 4362

<212> DNA

<213> Artificial sequence

<400> 17

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttact tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaaggag atcacccgca cgaccctgca gtcggatcag 2340

gaggagattg attacgacga cacgatcagt gtggagatga agaaggagga cttcgacatc 2400

tacgacgaag atgaaaacca gtcccctcgg tccttccaaa agaagacccg gcactacttc 2460

atcgccgctg tggaacgcct gtgggactat ggaatgtctt ctagccctca cgttttgagg 2520

aaccgcgccc agtcgggcag cgtgccccag ttcaagaaag tggtgttcca ggagttcacc 2580

gacggctcct tcacccagcc actttaccgg ggcgagctca atgaacatct gggcctgctg 2640

ggaccctaca tcagggctga ggtggaggac aacatcatgg tgacattccg gaatcaggcc 2700

agcagaccat acagtttcta cagttcactc atctcctacg aggaggacca gcgccagggg 2760

gctgaacccc gtaagaactt cgtgaagcca aacgaaacaa agacctactt ctggaaggtc 2820

cagcaccaca tggcacctac caaggacgag ttcgattgca aggcctgggc ctacttctcc 2880

gacgtggacc tggagaaaga tgtgcacagc ggcctgattg gccctctgct ggtgtgtcac 2940

acgaacacac tcaaccctgc acacgggcgg caggtcactg tgcaggaatt cgccctgttc 3000

tttaccatct ttgatgagac gaagtcctgg tatttcaccg aaaacatgga gaggaactgc 3060

cgcgcaccct gcaacatcca gatggaagat ccgacattca aggagaacta ccggttccat 3120

gccatcaatg gctacatcat ggacaccctg cctggcctcg tgatggccca agaccagcgt 3180

atccgctggt atctgctgtc gatgggctcc aacgagaaca tccatagtat ccacttcagc 3240

gggcatgtct tcacggtgag gaaaaaggag gagtacaaga tggcactgta caacctctat 3300

cccggcgtgt tcgagaccgt ggagatgctg ccctccaagg ccggcatctg gagagtggaa 3360

tgcctgatcg gcgagcacct ccacgctggg atgtccacgc tgttcctcgt ttacagcaat 3420

aagtgccaga cccctctggg catggcgagc ggccacatcc gcgacttcca gattacagcc 3480

agcggccagt acggtcagtg ggctccaaag ctggcccgtc tgcactactc cggatccatc 3540

aacgcctggt ccaccaagga accgttctcc tggatcaaag tagacctgct agcccccatg 3600

atcattcacg gcatcaagac acaaggcgcc cgacagaagt tctcgagcct ctatatctcc 3660

cagttcatca tcatgtatag cctggacgga aagaagtggc agacttaccg cggaaactcg 3720

acagggaccc tgatggtatt cttcggtaac gtggacagct ccggaatcaa gcacaacatc 3780

ttcaacccac ccattatcgc ccgctacatc cgcctgcacc ccactcacta tagcattagg 3840

tccaccctgc gaatggagct catgggctgt gacctgaaca gctgtagcat gcccctcggc 3900

atggagtcta aggcgatctc cgacgcacag ataacggcat catcctactt taccaacatg 3960

ttcgctacct ggtccccctc caaggcccga ctccacctgc aagggagatc caacgcctgg 4020

cggccacagg tcaacaatcc caaggagtgg ctgcaagtgg actttcagaa aactatgaaa 4080

gtcaccggag tgaccacaca gggagtgaag tctctgctga ccagcatgta cgtgaaggag 4140

ttcctcatct ccagttcgca ggatggccac cagtggacgt tgttcttcca aaacggtaaa 4200

gtcaaagtct tccaagggaa ccaggacagc tttacacccg tcgtgaactc cctggacccc 4260

ccgcttctca ctagatacct ccgcatccac cctcagagct gggtgcacca gattgccctg 4320

cgcatggagg ttctggggtg tgaagcccag gacctgtact aa 4362

<210> 18

<211> 4362

<212> DNA

<213> Artificial sequence

<400> 18

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttacc tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaaggag atcacccgca cgaccctgca gtcggatcag 2340

gaggagattg attacgacga cacgatcagt gtggagatga agaaggagga cttcgacatc 2400

tacgacgaag atgaaaacca gtcccctcgg tccttccaaa agaagacccg gcactacttc 2460

atcgccgctg tggaacgcct gtgggactat ggaatgtctt ctagccctca cgttttgagg 2520

aaccgcgccc agtcgggcag cgtgccccag ttcaagaaag tggtgttcca ggagttcacc 2580

gacggctcct tcacccagcc actttaccgg ggcgagctca atgaacatct gggcctgctg 2640

ggaccctaca tcagggctga ggtggaggac aacatcatgg tgacattccg gaatcaggcc 2700

agcagaccat acagtttcta cagttcactc atctcctacg aggaggacca gcgccagggg 2760

gctgaacccc gtaagaactt cgtgaagcca aacgaaacaa agacctactt ctggaaggtc 2820

cagcaccaca tggcacctac caaggacgag ttcgattgca aggcctgggc ctacttctcc 2880

gacgtggacc tggagaaaga tgtgcacagc ggcctgattg gccctctgct ggtgtgtcac 2940

acgaacacac tcaaccctgc acacgggcgg caggtcactg tgcaggaatt cgccctgttc 3000

tttaccatct ttgatgagac gaagtcctgg tatttcaccg aaaacatgga gaggaactgc 3060

cgcgcaccct gcaacatcca gatggaagat ccgacattca aggagaacta ccggttccat 3120

gccatcaatg gctacatcat ggacaccctg cctggcctcg tgatggccca agaccagcgt 3180

atccgctggt atctgctgtc gatgggctcc aacgagaaca tccatagtat ccacttcagc 3240

gggcatgtct tcacggtgag gaaaaaggag gagtacaaga tggcactgta caacctctat 3300

cccggcgtgt tcgagaccgt ggagatgctg ccctccaagg ccggcatctg gagagtggaa 3360

tgcctgatcg gcgagcacct ccacgctggg atgtccacgc tgttcctcgt ttacagcaat 3420

aagtgccaga cccctctggg catggcgagc ggccacatcc gcgacttcca gattacagcc 3480

agcggccagt acggtcagtg ggctccaaag ctggcccgtc tgcactactc cggatccatc 3540

aacgcctggt ccaccaagga accgttctcc tggatcaaag tagacctgct agcccccatg 3600

atcattcacg gcatcaagac acaaggcgcc cgacagaagt tctcgagcct ctatatctcc 3660

cagttcatca tcatgtatag cctggacgga aagaagtggc agacttaccg cggaaactcg 3720

acagggaccc tgatggtatt cttcggtaac gtggacagct ccggaatcaa gcacaacatc 3780

ttcaacccac ccattatcgc ccgctacatc cgcctgcacc ccactcacta tagcattagg 3840

tccaccctgc gaatggagct catgggctgt gacctgaaca gctgtagcat gcccctcggc 3900

atggagtcta aggcgatctc cgacgcacag ataacggcat catcctactt taccaacatg 3960

ttcgctacct ggtccccctc caaggcccga ctccacctgc aagggagatc caacgcctgg 4020

cggccacagg tcaacaatcc caaggagtgg ctgcaagtgg actttcagaa aactatgaaa 4080

gtcaccggag tgaccacaca gggagtgaag tctctgctga ccagcatgta cgtgaaggag 4140

ttcctcatct ccagttcgca ggatggccac cagtggacgt tgttcttcca aaacggtaaa 4200

gtcaaagtct tccaagggaa ccaggacagc tttacacccg tcgtgaactc cctggacccc 4260

ccgcttctca ctagatacct ccgcatccac cctcagagct gggtgcacca gattgccctg 4320

cgcatggagg ttctggggtg tgaagcccag gacctgtact aa 4362

<210> 19

<211> 4362

<212> DNA

<213> Artificial sequence

<400> 19

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttaca tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaaggag atcacccgca cgaccctgca gtcggatcag 2340

gaggagattg attacgacga cacgatcagt gtggagatga agaaggagga cttcgacatc 2400

tacgacgaag atgaaaacca gtcccctcgg tccttccaaa agaagacccg gcactacttc 2460

atcgccgctg tggaacgcct gtgggactat ggaatgtctt ctagccctca cgttttgagg 2520

aaccgcgccc agtcgggcag cgtgccccag ttcaagaaag tggtgttcca ggagttcacc 2580

gacggctcct tcacccagcc actttaccgg ggcgagctca atgaacatct gggcctgctg 2640

ggaccctaca tcagggctga ggtggaggac aacatcatgg tgacattccg gaatcaggcc 2700

agcagaccat acagtttcta cagttcactc atctcctacg aggaggacca gcgccagggg 2760

gctgaacccc gtaagaactt cgtgaagcca aacgaaacaa agacctactt ctggaaggtc 2820

cagcaccaca tggcacctac caaggacgag ttcgattgca aggcctgggc ctacttctcc 2880

gacgtggacc tggagaaaga tgtgcacagc ggcctgattg gccctctgct ggtgtgtcac 2940

acgaacacac tcaaccctgc acacgggcgg caggtcactg tgcaggaatt cgccctgttc 3000

tttaccatct ttgatgagac gaagtcctgg tatttcaccg aaaacatgga gaggaactgc 3060

cgcgcaccct gcaacatcca gatggaagat ccgacattca aggagaacta ccggttccat 3120

gccatcaatg gctacatcat ggacaccctg cctggcctcg tgatggccca agaccagcgt 3180

atccgctggt atctgctgtc gatgggctcc aacgagaaca tccatagtat ccacttcagc 3240

gggcatgtct tcacggtgag gaaaaaggag gagtacaaga tggcactgta caacctctat 3300

cccggcgtgt tcgagaccgt ggagatgctg ccctccaagg ccggcatctg gagagtggaa 3360

tgcctgatcg gcgagcacct ccacgctggg atgtccacgc tgttcctcgt ttacagcaat 3420

aagtgccaga cccctctggg catggcgagc ggccacatcc gcgacttcca gattacagcc 3480

agcggccagt acggtcagtg ggctccaaag ctggcccgtc tgcactactc cggatccatc 3540

aacgcctggt ccaccaagga accgttctcc tggatcaaag tagacctgct agcccccatg 3600

atcattcacg gcatcaagac acaaggcgcc cgacagaagt tctcgagcct ctatatctcc 3660

cagttcatca tcatgtatag cctggacgga aagaagtggc agacttaccg cggaaactcg 3720

acagggaccc tgatggtatt cttcggtaac gtggacagct ccggaatcaa gcacaacatc 3780

ttcaacccac ccattatcgc ccgctacatc cgcctgcacc ccactcacta tagcattagg 3840

tccaccctgc gaatggagct catgggctgt gacctgaaca gctgtagcat gcccctcggc 3900

atggagtcta aggcgatctc cgacgcacag ataacggcat catcctactt taccaacatg 3960

ttcgctacct ggtccccctc caaggcccga ctccacctgc aagggagatc caacgcctgg 4020

cggccacagg tcaacaatcc caaggagtgg ctgcaagtgg actttcagaa aactatgaaa 4080

gtcaccggag tgaccacaca gggagtgaag tctctgctga ccagcatgta cgtgaaggag 4140

ttcctcatct ccagttcgca ggatggccac cagtggacgt tgttcttcca aaacggtaaa 4200

gtcaaagtct tccaagggaa ccaggacagc tttacacccg tcgtgaactc cctggacccc 4260

ccgcttctca ctagatacct ccgcatccac cctcagagct gggtgcacca gattgccctg 4320

cgcatggagg ttctggggtg tgaagcccag gacctgtact aa 4362

<210> 20

<211> 4362

<212> DNA

<213> Artificial sequence

<400> 20

atgcagatcg aactgagcac ttgcttcttc ctgtgtctcc tgcgcttttg cttctccgcc 60

acaaggagat actatctcgg tgccgtggag ctcagctggg actacatgca gagcgacttg 120

ggtgaactgc ctgtggacgc caggtttcca ccccgcgtgc ccaagagttt cccgttcaac 180

accagtgtcg tgtacaagaa aaccctcttc gtggaattca ccgaccacct gttcaacatc 240

gccaaaccgc gccctccctg gatggggctg ctcggcccga cgatccaggc tgaggtctat 300

gacacggtgg tgattaccct caagaacatg gctagccacc cggtgagcct gcacgccgtg 360

ggcgtgtcct attggaaagc gtccgagggt gcggagtacg atgaccagac ttcacagcgg 420

gagaaggaag acgacaaagt gttccccggg ggttcccaca cctatgtctg gcaggtcctg 480

aaggagaatg gtcctatggc ctccgaccca ttgtgcctca cctactctta cctaagccat 540

gtggatctcg tcaaggacct gaactcgggg ctgatcggcg ccctgctcgt gtgccgggag 600

ggctcactgg ccaaggagaa gacccaaact ctgcacaagt tcatcctgct gttcgcggta 660

ttcgacgagg ggaagtcctg gcactccgag accaagaaca gcctgatgca ggaccgcgac 720

gcagcctcgg cccgtgcgtg gccaaagatg cacaccgtga acggctacgt taacaggagc 780

ctacccggcc tgatcggctg ccaccgcaaa tcggtctact ggcatgtgat cggaatgggc 840

acaacgcccg aggtccacag tatcttcctc gagggccaca ctttcctggt ccggaatcac 900

cgccaggcca gcctggagat cagccccata acctttctga cggcgcagac cttactcatg 960

gatctcggcc agttcctcct gttctgccac atttcgtccc accagcacga tgggatggaa 1020

gcatatgtga aagtggactc ctgccccgag gaaccccagc ttaggatgaa gaacaatgag 1080

gaggccgagg actacgacga tgaccttacc gattcagaaa tggacgtagt acgctttgac 1140

gacgacaact ctccatcctt catacagatt cgctccgtcg ccaagaagca ccctaagact 1200

tgggtgcact acatcgcggc cgaggaggag gactgggatt atgctcccct ggtgctggcc 1260

cccgacgacc gcagctacaa gagccagtac ctgaataacg ggccccagcg catcggccgg 1320

aagtacaaga aagtgcggtt catggcttac acggacgaga ccttcaagac ccgggaggct 1380

atccagcatg agagcggcat cttggggccc ctcctgtacg gcgaagttgg agacacactg 1440

ctgatcatct tcaagaacca ggcgagcagg ccctacaaca tctaccccca cggcattacc 1500

gatgtccggc cgttgtacag ccgacggctg cccaagggcg tgaagcacct gaaggacttt 1560

ccgatcctgc cgggcgagat cttcaagtac aagtggactg tgaccgtgga ggatgggccg 1620

accaagagcg atccgcgctg cctgacccgt tactactcca gctttgtcaa tatggagcgc 1680

gacctcgcta gcggcttgat tggccctctg ctgatctgct acaaggagtc cgtggaccag 1740

agggggaatc agatcatgag tgacaagagg aacgtgatcc tgttctccgt gttcgacgaa 1800

aaccgcagct ggtatctcac cgagaatatc cagcgcttcc tgcccaaccc ggccggtgtg 1860

cagctggagg accccgagtt tcaggccagc aacatcatgc attctatcaa cggatatgtg 1920

tttgattccc tgcagctctc agtgtgtctg cacgaggtcg cctactggta tatcctcagc 1980

attggggcac agaccgactt cctgagcgtg ttcttctccg ggtatacctt caagcacaag 2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct 2100

atggagaacc ccgggctctg gatccttacg tgccataact ccgacttccg caaccgcgga 2160

atgaccgcgc tcctgaaagt gtcgagttgt gacaagaaca ccggcgacta ttacgaggac 2220

agttacgagg acatctctgc gtacctcctt agcaagaata acgccatcga gccaagatcc 2280

ttcagccaga accccccagt gctgaaggag atcacccgca cgaccctgca gtcggatcag 2340

gaggagattg attacgacga cacgatcagt gtggagatga agaaggagga cttcgacatc 2400

tacgacgaag atgaaaacca gtcccctcgg tccttccaaa agaagacccg gcactacttc 2460

atcgccgctg tggaacgcct gtgggactat ggaatgtctt ctagccctca cgttttgagg 2520

aaccgcgccc agtcgggcag cgtgccccag ttcaagaaag tggtgttcca ggagttcacc 2580

gacggctcct tcacccagcc actttaccgg ggcgagctca atgaacatct gggcctgctg 2640

ggaccctaca tcagggctga ggtggaggac aacatcatgg tgacattccg gaatcaggcc 2700

agcagaccat acagtttcta cagttcactc atctcctacg aggaggacca gcgccagggg 2760

gctgaacccc gtaagaactt cgtgaagcca aacgaaacaa agacctactt ctggaaggtc 2820

cagcaccaca tggcacctac caaggacgag ttcgattgca aggcctgggc ctacttctcc 2880

gacgtggacc tggagaaaga tgtgcacagc ggcctgattg gccctctgct ggtgtgtcac 2940

acgaacacac tcaaccctgc acacgggcgg caggtcactg tgcaggaatt cgccctgttc 3000

tttaccatct ttgatgagac gaagtcctgg tatttcaccg aaaacatgga gaggaactgc 3060

cgcgcaccct gcaacatcca gatggaagat ccgacattca aggagaacta ccggttccat 3120

gccatcaatg gctacatcat ggacaccctg cctggcctcg tgatggccca agaccagcgt 3180

atccgctggt atctgctgtc gatgggctcc aacgagaaca tccatagtat ccacttcagc 3240

gggcatgtct tcacggtgag gaaaaaggag gagtacaaga tggcactgta caacctctat 3300

cccggcgtgt tcgagaccgt ggagatgctg ccctccaagg ccggcatctg gagagtggaa 3360

tgcctgatcg gcgagcacct ccacgctggg atgtccacgc tgttcctcgt ttacagcaat 3420

aagtgccaga cccctctggg catggcgagc ggccacatcc gcgacttcca gattacagcc 3480

agcggccagt acggtcagtg ggctccaaag ctggcccgtc tgcactactc cggatccatc 3540

aacgcctggt ccaccaagga accgttctcc tggatcaaag tagacctgct agcccccatg 3600

atcattcacg gcatcaagac acaaggcgcc cgacagaagt tctcgagcct ctatatctcc 3660

cagttcatca tcatgtatag cctggacgga aagaagtggc agacttaccg cggaaactcg 3720

acagggaccc tgatggtatt cttcggtaac gtggacagct ccggaatcaa gcacaacatc 3780

ttcaacccac ccattatcgc ccgctacatc cgcctgcacc ccactcacta tagcattagg 3840

tccaccctgc gaatggagct catgggctgt gacctgaaca gctgtagcat gcccctcggc 3900

atggagtcta aggcgatctc cgacgcacag ataacggcat catcctactt taccaacatg 3960

ttcgctacct ggtccccctc caaggcccga ctccacctgc aagggagatc caacgcctgg 4020

cggccacagg tcaacaatcc caaggagtgg ctgcaagtgg actttcagaa aactatgaaa 4080

gtcaccggag tgaccacaca gggagtgaag tctctgctga ccagcatgta cgtgaaggag 4140

ttcctcatct ccagttcgca ggatggccac cagtggacgt tgttcttcca aaacggtaaa 4200

gtcaaagtct tccaagggaa ccaggacagc tttacacccg tcgtgaactc cctggacccc 4260

ccgcttctca ctagatacct ccgcatccac cctcagagct gggtgcacca gattgccctg 4320

cgcatggagg ttctggggtg tgaagcccag gacctgtact aa 4362

<210> 21

<211> 2351

<212> PRT

<213> Artificial sequence

<400> 21

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe

1 5 10 15

Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg

35 40 45

Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val

50 55 60

Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile

65 70 75 80

Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln

85 90 95

Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser

100 105 110

His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser

115 120 125

Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp

130 135 140

Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu

145 150 155 160

Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser

165 170 175

Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile

180 185 190

Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr

195 200 205

Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly

210 215 220

Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp

225 230 235 240

Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr

245 250 255

Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val

260 265 270

Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile

275 280 285

Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser

290 295 300

Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met

305 310 315 320

Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His

325 330 335

Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro

340 345 350

Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp

355 360 365

Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser

370 375 380

Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn

420 425 430

Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met

435 440 445

Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys

500 505 510

Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Ile Leu Thr Cys His Asn Ser Asp Phe Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp

725 730 735

Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys

740 745 750

Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro

755 760 765

Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp

770 775 780

Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys

785 790 795 800

Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser

805 810 815

Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr

820 825 830

Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn

835 840 845

Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly

850 855 860

Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu

865 870 875 880

Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys

885 890 895

Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn

900 905 910

Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met

915 920 925

Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys

930 935 940

Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu

945 950 955 960

Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu

965 970 975

Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe

980 985 990

Lys Gly Lys Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala

995 1000 1005

Leu Phe Lys Val Ser Ile Ser Leu Leu Lys Thr Asn Lys Thr Ser

1010 1015 1020

Asn Asn Ser Ala Thr Asn Arg Lys Thr His Ile Asp Gly Pro Ser

1025 1030 1035

Leu Leu Ile Glu Asn Ser Pro Ser Val Trp Gln Asn Ile Leu Glu

1040 1045 1050

Ser Asp Thr Glu Phe Lys Lys Val Thr Pro Leu Ile His Asp Arg

1055 1060 1065

Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg Leu Asn His Met

1070 1075 1080

Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met Val Gln Gln

1085 1090 1095

Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro Asp Met

1100 1105 1110

Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp Ile

1115 1120 1125

Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro

1130 1135 1140

Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu

1145 1150 1155

Gly Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys

1160 1165 1170

Gly Glu Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro

1175 1180 1185

Ser Ser Arg Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu

1190 1195 1200

Asn Asn Thr His Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu

1205 1210 1215

Lys Lys Glu Thr Leu Ile Gln Glu Asn Val Val Leu Pro Gln Ile

1220 1225 1230

His Thr Val Thr Gly Thr Lys Asn Phe Met Lys Asn Leu Phe Leu

1235 1240 1245

Leu Ser Thr Arg Gln Asn Val Glu Gly Ser Tyr Asp Gly Ala Tyr

1250 1255 1260

Ala Pro Val Leu Gln Asp Phe Arg Ser Leu Asn Asp Ser Thr Asn

1265 1270 1275

Arg Thr Lys Lys His Thr Ala His Phe Ser Lys Lys Gly Glu Glu

1280 1285 1290

Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr Lys Gln Ile Val Glu

1295 1300 1305

Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln Gln

1310 1315 1320

Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys Gln Phe Arg

1325 1330 1335

Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile Val Asp

1340 1345 1350

Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr Pro

1355 1360 1365

Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala

1370 1375 1380

Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser

1385 1390 1395

Ile Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser

1400 1405 1410

Ser Phe Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe

1415 1420 1425

Gln Asp Asn Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys

1430 1435 1440

Asp Ser Gly Val Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys

1445 1450 1455

Lys Asn Asn Leu Ser Leu Ala Ile Leu Thr Leu Glu Met Thr Gly

1460 1465 1470

Asp Gln Arg Glu Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser

1475 1480 1485

Val Thr Tyr Lys Lys Val Glu Asn Thr Val Leu Pro Lys Pro Asp

1490 1495 1500

Leu Pro Lys Thr Ser Gly Lys Val Glu Leu Leu Pro Lys Val His

1505 1510 1515

Ile Tyr Gln Lys Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser

1520 1525 1530

Pro Gly His Leu Asp Leu Val Glu Gly Ser Leu Leu Gln Gly Thr

1535 1540 1545

Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val

1550 1555 1560

Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser

1565 1570 1575

Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly Thr Gln

1580 1585 1590

Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu Lys

1595 1600 1605

Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys

1610 1615 1620

Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys

1625 1630 1635

Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg

1640 1645 1650

Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu

1655 1660 1665

Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr

1670 1675 1680

Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile

1685 1690 1695

Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys

1700 1705 1710

Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr

1715 1720 1725

Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser

1730 1735 1740

Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr

1745 1750 1755

Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu

1760 1765 1770

His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp

1775 1780 1785

Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser

1790 1795 1800

Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly

1805 1810 1815

Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr

1820 1825 1830

Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu

1835 1840 1845

Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu

1850 1855 1860

Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His

1865 1870 1875

Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln

1880 1885 1890

Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp

1895 1900 1905

Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn

1910 1915 1920

Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His

1925 1930 1935

Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met

1940 1945 1950

Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser

1955 1960 1965

Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr

1970 1975 1980

Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr

1985 1990 1995

Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly

2000 2005 2010

Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly

2015 2020 2025

Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro

2030 2035 2040

Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala

2045 2050 2055

Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His

2060 2065 2070

Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser

2075 2080 2085

Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile

2090 2095 2100

Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser

2105 2110 2115

Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr

2120 2125 2130

Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn

2135 2140 2145

Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile

2150 2155 2160

Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg

2165 2170 2175

Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys

2180 2185 2190

Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln

2195 2200 2205

Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser

2210 2215 2220

Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp

2225 2230 2235

Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe

2240 2245 2250

Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys

2255 2260 2265

Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser

2270 2275 2280

Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys

2285 2290 2295

Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val

2300 2305 2310

Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His

2315 2320 2325

Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu

2330 2335 2340

Gly Cys Glu Ala Gln Asp Leu Tyr

2345 2350

<210> 22

<211> 1457

<212> PRT

<213> Artificial sequence

<400> 22

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe

1 5 10 15

Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg

35 40 45

Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val

50 55 60

Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile

65 70 75 80

Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln

85 90 95

Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser

100 105 110

His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser

115 120 125

Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp

130 135 140

Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu

145 150 155 160

Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser

165 170 175

Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile

180 185 190

Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr

195 200 205

Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly

210 215 220

Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp

225 230 235 240

Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr

245 250 255

Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val

260 265 270

Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile

275 280 285

Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser

290 295 300

Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met

305 310 315 320

Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His

325 330 335

Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro

340 345 350

Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp

355 360 365

Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser

370 375 380

Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn

420 425 430

Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met

435 440 445

Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys

500 505 510

Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Ile Leu Thr Cys His Asn Ser Asp Phe Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp

725 730 735

Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys

740 745 750

Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu

755 760 765

Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln

770 775 780

Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu

785 790 795 800

Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe

805 810 815

Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp

820 825 830

Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln

835 840 845

Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr

850 855 860

Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His

865 870 875 880

Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile

885 890 895

Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser

900 905 910

Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg

915 920 925

Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val

930 935 940

Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp

945 950 955 960

Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu

965 970 975

Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His

980 985 990

Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe

995 1000 1005

Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn

1010 1015 1020

Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys

1025 1030 1035

Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr

1040 1045 1050

Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr

1055 1060 1065

Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe

1070 1075 1080

Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met

1085 1090 1095

Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met

1100 1105 1110

Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly

1115 1120 1125

Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser

1130 1135 1140

Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg

1145 1150 1155

Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro

1160 1165 1170

Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser

1175 1180 1185

Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro

1190 1195 1200

Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe

1205 1210 1215

Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp

1220 1225 1230

Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu

1235 1240 1245

Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn

1250 1255 1260

Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro

1265 1270 1275

Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly

1280 1285 1290

Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys

1295 1300 1305

Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn

1310 1315 1320

Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln

1325 1330 1335

Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu

1340 1345 1350

Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val

1355 1360 1365

Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys

1370 1375 1380

Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu

1385 1390 1395

Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp

1400 1405 1410

Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr

1415 1420 1425

Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala

1430 1435 1440

Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr

1445 1450 1455

<210> 23

<211> 1464

<212> PRT

<213> Artificial sequence

<400> 23

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe

1 5 10 15

Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg

35 40 45

Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val

50 55 60

Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile

65 70 75 80

Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln

85 90 95

Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser

100 105 110

His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser

115 120 125

Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp

130 135 140

Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu

145 150 155 160

Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser

165 170 175

Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile

180 185 190

Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr

195 200 205

Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly

210 215 220

Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp

225 230 235 240

Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr

245 250 255

Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val

260 265 270

Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile

275 280 285

Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser

290 295 300

Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met

305 310 315 320

Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His

325 330 335

Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro

340 345 350

Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp

355 360 365

Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser

370 375 380

Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn

420 425 430

Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met

435 440 445

Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys

500 505 510

Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Ile Leu Thr Cys His Asn Ser Asp Phe Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp

725 730 735

Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys

740 745 750

Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro

755 760 765

Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg

770 775 780

Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile

785 790 795 800

Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu

805 810 815

Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile

820 825 830

Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His

835 840 845

Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys

850 855 860

Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr

865 870 875 880

Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg

885 890 895

Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser

900 905 910

Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln

915 920 925

Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr

930 935 940

Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp

945 950 955 960

Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu

965 970 975

Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr

980 985 990

Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe

995 1000 1005

Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe

1010 1015 1020

Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln

1025 1030 1035

Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile

1040 1045 1050

Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln

1055 1060 1065

Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu

1070 1075 1080

Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg

1085 1090 1095

Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly

1100 1105 1110

Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp

1115 1120 1125

Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser

1130 1135 1140

Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly

1145 1150 1155

Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly

1160 1165 1170

Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser

1175 1180 1185

Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile

1190 1195 1200

Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr

1205 1210 1215

Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe

1220 1225 1230

Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg

1235 1240 1245

Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp

1250 1255 1260

Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala

1265 1270 1275

Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr

1280 1285 1290

Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met

1295 1300 1305

Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr

1310 1315 1320

Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser

1325 1330 1335

Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro

1340 1345 1350

Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys

1355 1360 1365

Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu

1370 1375 1380

Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln

1385 1390 1395

Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys

1400 1405 1410

Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser

1415 1420 1425

Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln

1430 1435 1440

Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys

1445 1450 1455

Glu Ala Gln Asp Leu Tyr

1460

<210> 24

<211> 1463

<212> PRT

<213> Artificial sequence

<400> 24

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe

1 5 10 15

Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg

35 40 45

Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val

50 55 60

Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile

65 70 75 80

Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln

85 90 95

Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser

100 105 110

His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser

115 120 125

Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp

130 135 140

Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu

145 150 155 160

Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser

165 170 175

Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile

180 185 190

Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr

195 200 205

Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly

210 215 220

Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp

225 230 235 240

Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr

245 250 255

Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val

260 265 270

Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile

275 280 285

Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser

290 295 300

Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met

305 310 315 320

Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His

325 330 335

Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro

340 345 350

Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp

355 360 365

Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser

370 375 380

Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn

420 425 430

Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met

435 440 445

Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys

500 505 510

Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Ile Leu Thr Cys His Asn Ser Asp Phe Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp

725 730 735

Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys

740 745 750

Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro

755 760 765

Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Thr

770 775 780

Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser

785 790 795 800

Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn

805 810 815

Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala

820 825 830

Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val

835 840 845

Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val

850 855 860

Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg

865 870 875 880

Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala

885 890 895

Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg

900 905 910

Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg

915 920 925

Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys

930 935 940

Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu

945 950 955 960

Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys

965 970 975

Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn

980 985 990

Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala

995 1000 1005

Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr

1010 1015 1020

Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met

1025 1030 1035

Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn

1040 1045 1050

Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp

1055 1060 1065

Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn

1070 1075 1080

Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys

1085 1090 1095

Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val

1100 1105 1110

Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg

1115 1120 1125

Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr

1130 1135 1140

Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met

1145 1150 1155

Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln

1160 1165 1170

Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly

1175 1180 1185

Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys

1190 1195 1200

Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln

1205 1210 1215

Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile

1220 1225 1230

Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly

1235 1240 1245

Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser

1250 1255 1260

Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg

1265 1270 1275

Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu

1280 1285 1290

Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro

1295 1300 1305

Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala

1310 1315 1320

Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys

1325 1330 1335

Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln

1340 1345 1350

Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr

1355 1360 1365

Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu

1370 1375 1380

Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp

1385 1390 1395

Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val

1400 1405 1410

Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu

1415 1420 1425

Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser

1430 1435 1440

Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu

1445 1450 1455

Ala Gln Asp Leu Tyr

1460

<210> 25

<211> 1453

<212> PRT

<213> Artificial sequence

<400> 25

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe

1 5 10 15

Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg

35 40 45

Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val

50 55 60

Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile

65 70 75 80

Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln

85 90 95

Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser

100 105 110

His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser

115 120 125

Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp

130 135 140

Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu

145 150 155 160

Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser

165 170 175

Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile

180 185 190

Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr

195 200 205

Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly

210 215 220

Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp

225 230 235 240

Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr

245 250 255

Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val

260 265 270

Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile

275 280 285

Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser

290 295 300

Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met

305 310 315 320

Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His

325 330 335

Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro

340 345 350

Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp

355 360 365

Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser

370 375 380

Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn

420 425 430

Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met

435 440 445

Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys

500 505 510

Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Ile Leu Thr Cys His Asn Ser Asp Phe Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp

725 730 735

Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys

740 745 750

Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu

755 760 765

Lys Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp

770 775 780

Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile

785 790 795 800

Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr

805 810 815

Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met

820 825 830

Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val

835 840 845

Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe

850 855 860

Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu

865 870 875 880

Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe

885 890 895

Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser

900 905 910

Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val

915 920 925

Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met

930 935 940

Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser

945 950 955 960

Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu

965 970 975

Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val

980 985 990

Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys

995 1000 1005

Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro

1010 1015 1020

Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg

1025 1030 1035

Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu

1040 1045 1050

Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met

1055 1060 1065

Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val

1070 1075 1080

Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn

1085 1090 1095

Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys

1100 1105 1110

Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His

1115 1120 1125

Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln

1130 1135 1140

Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile

1145 1150 1155

Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg

1160 1165 1170

Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro

1175 1180 1185

Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His

1190 1195 1200

Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr

1205 1210 1215

Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp

1220 1225 1230

Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe

1235 1240 1245

Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro

1250 1255 1260

Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser

1265 1270 1275

Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn

1280 1285 1290

Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp

1295 1300 1305

Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr

1310 1315 1320

Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn

1325 1330 1335

Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val

1340 1345 1350

Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly

1355 1360 1365

Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile

1370 1375 1380

Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn

1385 1390 1395

Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro

1400 1405 1410

Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg

1415 1420 1425

Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu

1430 1435 1440

Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr

1445 1450

<210> 26

<211> 1474

<212> PRT

<213> Artificial sequence

<400> 26

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe

1 5 10 15

Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg

35 40 45

Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val

50 55 60

Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile

65 70 75 80

Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln

85 90 95

Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser

100 105 110

His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser

115 120 125

Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp

130 135 140

Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu

145 150 155 160

Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser

165 170 175

Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile

180 185 190

Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr

195 200 205

Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly

210 215 220

Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp

225 230 235 240

Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr

245 250 255

Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val

260 265 270

Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile

275 280 285

Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser

290 295 300

Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met

305 310 315 320

Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His

325 330 335

Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro

340 345 350

Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp

355 360 365

Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser

370 375 380

Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn

420 425 430

Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met

435 440 445

Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys

500 505 510

Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Ile Leu Thr Cys His Asn Ser Asp Phe Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp

725 730 735

Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys

740 745 750

Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ala Thr Asn Val

755 760 765

Ser Asn Asn Ser Asn Thr Ser Asn Asp Ser Asn Val Ser Pro Pro Val

770 775 780

Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp

785 790 795 800

Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys

805 810 815

Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser

820 825 830

Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu

835 840 845

Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala

850 855 860

Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe

865 870 875 880

Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu

885 890 895

His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn

900 905 910

Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr

915 920 925

Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro

930 935 940

Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys

945 950 955 960

Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala

965 970 975

Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly

980 985 990

Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala

995 1000 1005

His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr

1010 1015 1020

Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu

1025 1030 1035

Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr

1040 1045 1050

Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met

1055 1060 1065

Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg

1070 1075 1080

Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile

1085 1090 1095

His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr

1100 1105 1110

Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val

1115 1120 1125

Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu

1130 1135 1140

Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val

1145 1150 1155

Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His

1160 1165 1170

Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp

1175 1180 1185

Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala

1190 1195 1200

Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu

1205 1210 1215

Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln

1220 1225 1230

Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser

1235 1240 1245

Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly

1250 1255 1260

Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys

1265 1270 1275

His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu

1280 1285 1290

His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu

1295 1300 1305

Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu

1310 1315 1320

Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe

1325 1330 1335

Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His

1340 1345 1350

Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro

1355 1360 1365

Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr

1370 1375 1380

Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr

1385 1390 1395

Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp

1400 1405 1410

Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn

1415 1420 1425

Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu

1430 1435 1440

Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln

1445 1450 1455

Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu

1460 1465 1470

Tyr

<210> 27

<211> 1459

<212> PRT

<213> Artificial sequence

<400> 27

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe

1 5 10 15

Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg

35 40 45

Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val

50 55 60

Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile

65 70 75 80

Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln

85 90 95

Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser

100 105 110

His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser

115 120 125

Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp

130 135 140

Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu

145 150 155 160

Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser

165 170 175

Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile

180 185 190

Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr

195 200 205

Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly

210 215 220

Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp

225 230 235 240

Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr

245 250 255

Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val

260 265 270

Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile

275 280 285

Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser

290 295 300

Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met

305 310 315 320

Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His

325 330 335

Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro

340 345 350

Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp

355 360 365

Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser

370 375 380

Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn

420 425 430

Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met

435 440 445

Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys

500 505 510

Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Ile Leu Thr Cys His Asn Ser Asp Phe Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp

725 730 735

Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys

740 745 750

Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Gln

755 760 765

Ala Tyr Arg Tyr Arg Arg Gly Glu Ile Thr Arg Thr Thr Leu Gln Ser

770 775 780

Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys

785 790 795 800

Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg

805 810 815

Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg

820 825 830

Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg

835 840 845

Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu

850 855 860

Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn

865 870 875 880

Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp

885 890 895

Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe

900 905 910

Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu

915 920 925

Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp

930 935 940

Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys

945 950 955 960

Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser

965 970 975

Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro

980 985 990

Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr

995 1000 1005

Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu

1010 1015 1020

Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr

1025 1030 1035

Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met

1040 1045 1050

Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg

1055 1060 1065

Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile

1070 1075 1080

His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr

1085 1090 1095

Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val

1100 1105 1110

Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu

1115 1120 1125

Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val

1130 1135 1140

Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His

1145 1150 1155

Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp

1160 1165 1170

Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala

1175 1180 1185

Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu

1190 1195 1200

Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln

1205 1210 1215

Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser

1220 1225 1230

Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly

1235 1240 1245

Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys

1250 1255 1260

His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu

1265 1270 1275

His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu

1280 1285 1290

Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu

1295 1300 1305

Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe

1310 1315 1320

Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His

1325 1330 1335

Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro

1340 1345 1350

Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr

1355 1360 1365

Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr

1370 1375 1380

Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp

1385 1390 1395

Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn

1400 1405 1410

Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu

1415 1420 1425

Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln

1430 1435 1440

Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu

1445 1450 1455

Tyr

<210> 28

<211> 2133

<212> PRT

<213> Artificial sequence

<400> 28

Met Gln Leu Glu Leu Ser Thr Cys Val Phe Leu Cys Leu Leu Pro Leu

1 5 10 15

Gly Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Arg Gln Ser Glu Leu Leu Arg Glu Leu His Val Asp Thr

35 40 45

Arg Phe Pro Ala Thr Ala Pro Gly Ala Leu Pro Leu Gly Pro Ser Val

50 55 60

Leu Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Ser

65 70 75 80

Val Ala Arg Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile

85 90 95

Gln Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Met Ala

100 105 110

Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Phe Trp Lys Ser

115 120 125

Ser Glu Gly Ala Glu Tyr Glu Asp His Thr Ser Gln Arg Glu Lys Glu

130 135 140

Asp Asp Lys Val Leu Pro Gly Lys Ser Gln Thr Tyr Val Trp Gln Val

145 150 155 160

Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr

165 170 175

Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu

180 185 190

Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Arg Glu Arg

195 200 205

Thr Gln Asn Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu

210 215 220

Gly Lys Ser Trp His Ser Ala Arg Asn Asp Ser Trp Thr Arg Ala Met

225 230 235 240

Asp Pro Ala Pro Ala Arg Ala Gln Pro Ala Met His Thr Val Asn Gly

245 250 255

Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser

260 265 270

Val Tyr Trp His Val Ile Gly Met Gly Thr Ser Pro Glu Val His Ser

275 280 285

Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg His His Arg Gln Ala

290 295 300

Ser Leu Glu Ile Ser Pro Leu Thr Phe Leu Thr Ala Gln Thr Phe Leu

305 310 315 320

Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His His

325 330 335

His Gly Gly Met Glu Ala His Val Arg Val Glu Ser Cys Ala Glu Glu

340 345 350

Pro Gln Leu Arg Arg Lys Ala Asp Glu Glu Glu Asp Tyr Asp Asp Asn

355 360 365

Leu Tyr Asp Ser Asp Met Asp Val Val Arg Leu Asp Gly Asp Asp Val

370 375 380

Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Ala Val Pro Ser Pro Ser Asp Arg Ser Tyr Lys Ser Leu Tyr Leu Asn

420 425 430

Ser Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Ala Arg Phe Val

435 440 445

Ala Tyr Thr Asp Val Thr Phe Lys Thr Arg Lys Ala Ile Pro Tyr Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Lys Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Ser Ala Leu His Pro Gly Arg Leu Leu Lys

500 505 510

Gly Trp Lys His Leu Lys Asp Met Pro Ile Leu Pro Gly Glu Thr Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Ser Ile Asn Leu Glu Lys

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Leu Ala Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Asp Gly Leu Gln Pro Gln Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Val Leu Thr Cys His Asn Ser Asp Leu Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Tyr Ser Cys Asp Arg Asp Ile Gly Asp

725 730 735

Tyr Tyr Asp Asn Thr Tyr Glu Asp Ile Pro Gly Phe Leu Leu Ser Gly

740 745 750

Lys Asn Val Ile Glu Pro Arg Ser Phe Ala Gln Asn Ser Arg Pro Pro

755 760 765

Ser Ala Ser Gln Lys Gln Phe Gln Thr Ile Thr Ser Pro Glu Asp Asp

770 775 780

Val Glu Leu Asp Pro Gln Ser Gly Glu Arg Thr Gln Ala Leu Glu Glu

785 790 795 800

Leu Ser Val Pro Ser Gly Asp Gly Ser Met Leu Leu Gly Gln Asn Pro

805 810 815

Ala Pro His Gly Ser Ser Ser Ser Asp Leu Gln Glu Ala Arg Asn Glu

820 825 830

Ala Asp Asp Tyr Leu Pro Gly Ala Arg Glu Arg Asn Thr Ala Pro Ser

835 840 845

Ala Ala Ala Arg Leu Arg Pro Glu Leu His His Ser Ala Glu Arg Val

850 855 860

Leu Thr Pro Glu Pro Glu Lys Glu Leu Lys Lys Leu Asp Ser Lys Met

865 870 875 880

Ser Ser Ser Ser Asp Leu Leu Lys Thr Ser Pro Thr Ile Pro Ser Asp

885 890 895

Thr Leu Ser Ala Glu Thr Glu Arg Thr His Ser Leu Gly Pro Pro His

900 905 910

Pro Gln Val Asn Phe Arg Ser Gln Leu Gly Ala Ile Val Leu Gly Lys

915 920 925

Asn Ser Ser His Phe Ile Gly Ala Gly Val Pro Leu Gly Ser Thr Glu

930 935 940

Glu Asp His Glu Ser Ser Leu Gly Glu Asn Val Ser Pro Val Glu Ser

945 950 955 960

Asp Gly Ile Phe Glu Lys Glu Arg Ala His Gly Pro Ala Ser Leu Thr

965 970 975

Lys Asp Asp Val Leu Phe Lys Val Asn Ile Ser Leu Val Lys Thr Asn

980 985 990

Lys Ala Arg Val Tyr Leu Lys Thr Asn Arg Lys Ile His Ile Asp Asp

995 1000 1005

Ala Ala Leu Leu Thr Glu Asn Arg Ala Ser Ala Thr Phe Met Asp

1010 1015 1020

Lys Asn Thr Thr Ala Ser Gly Leu Asn His Val Ser Asn Trp Ile

1025 1030 1035

Lys Gly Pro Leu Gly Lys Asn Pro Leu Ser Ser Glu Arg Gly Pro

1040 1045 1050

Ser Pro Glu Leu Leu Thr Ser Ser Gly Ser Gly Lys Ser Val Lys

1055 1060 1065

Gly Gln Ser Ser Gly Gln Gly Arg Ile Arg Val Ala Val Glu Glu

1070 1075 1080

Glu Glu Leu Ser Lys Gly Lys Glu Met Met Leu Pro Asn Ser Glu

1085 1090 1095

Leu Thr Phe Leu Thr Asn Ser Ala Asp Val Gln Gly Asn Asp Thr

1100 1105 1110

His Ser Gln Gly Lys Lys Ser Arg Glu Glu Met Glu Arg Arg Glu

1115 1120 1125

Lys Leu Val Gln Glu Lys Val Asp Leu Pro Gln Val Tyr Thr Ala

1130 1135 1140

Thr Gly Thr Lys Asn Phe Leu Arg Asn Ile Phe His Gln Ser Thr

1145 1150 1155

Glu Pro Ser Val Glu Gly Phe Asp Gly Gly Ser His Ala Pro Val

1160 1165 1170

Pro Gln Asp Ser Arg Ser Leu Asn Asp Ser Ala Glu Arg Ala Glu

1175 1180 1185

Thr His Ile Ala His Phe Ser Ala Ile Arg Glu Glu Ala Pro Leu

1190 1195 1200

Glu Ala Pro Gly Asn Arg Thr Gly Pro Gly Pro Arg Ser Ala Val

1205 1210 1215

Pro Arg Arg Val Lys Gln Ser Leu Lys Gln Ile Arg Leu Pro Leu

1220 1225 1230

Glu Glu Ile Lys Pro Glu Arg Gly Val Val Leu Asn Ala Thr Ser

1235 1240 1245

Thr Arg Trp Ser Glu Ser Ser Pro Ile Leu Gln Gly Ala Lys Arg

1250 1255 1260

Asn Asn Leu Ser Leu Pro Phe Leu Thr Leu Glu Met Ala Gly Gly

1265 1270 1275

Gln Gly Lys Ile Ser Ala Leu Gly Lys Ser Ala Ala Gly Pro Leu

1280 1285 1290

Ala Ser Gly Lys Leu Glu Lys Ala Val Leu Ser Ser Ala Gly Leu

1295 1300 1305

Ser Glu Ala Ser Gly Lys Ala Glu Phe Leu Pro Lys Val Arg Val

1310 1315 1320

His Arg Glu Asp Leu Leu Pro Gln Lys Thr Ser Asn Val Ser Cys

1325 1330 1335

Ala His Gly Asp Leu Gly Gln Glu Ile Phe Leu Gln Lys Thr Arg

1340 1345 1350

Gly Pro Val Asn Leu Asn Lys Val Asn Arg Pro Gly Arg Thr Pro

1355 1360 1365

Ser Lys Leu Leu Gly Pro Pro Met Pro Lys Glu Trp Glu Ser Leu

1370 1375 1380

Glu Lys Ser Pro Lys Ser Thr Ala Leu Arg Thr Lys Asp Ile Ile

1385 1390 1395

Ser Leu Pro Leu Asp Arg His Glu Ser Asn His Ser Ile Ala Ala

1400 1405 1410

Lys Asn Glu Gly Gln Ala Glu Thr Gln Arg Glu Ala Ala Trp Thr

1415 1420 1425

Lys Gln Gly Gly Pro Gly Arg Leu Cys Ala Pro Lys Pro Pro Val

1430 1435 1440

Leu Arg Arg His Gln Arg Asp Ile Ser Leu Pro Thr Phe Gln Pro

1445 1450 1455

Glu Glu Asp Lys Met Asp Tyr Asp Asp Ile Phe Ser Thr Glu Thr

1460 1465 1470

Lys Gly Glu Asp Phe Asp Ile Tyr Gly Glu Asp Glu Asn Gln Asp

1475 1480 1485

Pro Arg Ser Phe Gln Lys Arg Thr Arg His Tyr Phe Ile Ala Ala

1490 1495 1500

Val Glu Gln Leu Trp Asp Tyr Gly Met Ser Glu Ser Pro Arg Ala

1505 1510 1515

Leu Arg Asn Arg Ala Gln Asn Gly Glu Val Pro Arg Phe Lys Lys

1520 1525 1530

Val Val Phe Arg Glu Phe Ala Asp Gly Ser Phe Thr Gln Pro Ser

1535 1540 1545

Tyr Arg Gly Glu Leu Asn Lys His Leu Gly Leu Leu Gly Pro Tyr

1550 1555 1560

Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Lys Asn

1565 1570 1575

Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr

1580 1585 1590

Pro Asp Asp Gln Glu Gln Gly Ala Glu Pro Arg His Asn Phe Val

1595 1600 1605

Gln Pro Asn Glu Thr Arg Thr Tyr Phe Trp Lys Val Gln His His

1610 1615 1620

Met Ala Pro Thr Glu Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr

1625 1630 1635

Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile

1640 1645 1650

Gly Pro Leu Leu Ile Cys Arg Ala Asn Thr Leu Asn Ala Ala His

1655 1660 1665

Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile

1670 1675 1680

Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Val Glu Arg

1685 1690 1695

Asn Cys Arg Ala Pro Cys His Leu Gln Met Glu Asp Pro Thr Leu

1700 1705 1710

Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Val Met Asp

1715 1720 1725

Thr Leu Pro Gly Leu Val Met Ala Gln Asn Gln Arg Ile Arg Trp

1730 1735 1740

Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His

1745 1750 1755

Phe Ser Gly His Val Phe Ser Val Arg Lys Lys Glu Glu Tyr Lys

1760 1765 1770

Met Ala Val Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu

1775 1780 1785

Met Leu Pro Ser Lys Val Gly Ile Trp Arg Ile Glu Cys Leu Ile

1790 1795 1800

Gly Glu His Leu Gln Ala Gly Met Ser Thr Thr Phe Leu Val Tyr

1805 1810 1815

Ser Lys Glu Cys Gln Ala Pro Leu Gly Met Ala Ser Gly Arg Ile

1820 1825 1830

Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala

1835 1840 1845

Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp

1850 1855 1860

Ser Thr Lys Asp Pro His Ser Trp Ile Lys Val Asp Leu Leu Ala

1865 1870 1875

Pro Met Ile Ile His Gly Ile Met Thr Gln Gly Ala Arg Gln Lys

1880 1885 1890

Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu

1895 1900 1905

Asp Gly Arg Asn Trp Gln Ser Tyr Arg Gly Asn Ser Thr Gly Thr

1910 1915 1920

Leu Met Val Phe Phe Gly Asn Val Asp Ala Ser Gly Ile Lys His

1925 1930 1935

Asn Ile Phe Asn Pro Pro Ile Val Ala Arg Tyr Ile Arg Leu His

1940 1945 1950

Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met

1955 1960 1965

Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Gln Asn

1970 1975 1980

Lys Ala Ile Ser Asp Ser Gln Ile Thr Ala Ser Ser His Leu Ser

1985 1990 1995

Asn Ile Phe Ala Thr Trp Ser Pro Ser Gln Ala Arg Leu His Leu

2000 2005 2010

Gln Gly Arg Thr Asn Ala Trp Arg Pro Arg Val Ser Ser Ala Glu

2015 2020 2025

Glu Trp Leu Gln Val Asp Leu Gln Lys Thr Val Lys Val Thr Gly

2030 2035 2040

Ile Thr Thr Gln Gly Val Lys Ser Leu Leu Ser Ser Met Tyr Val

2045 2050 2055

Lys Glu Phe Leu Val Ser Ser Ser Gln Asp Gly Arg Arg Trp Thr

2060 2065 2070

Leu Phe Leu Gln Asp Gly His Thr Lys Val Phe Gln Gly Asn Gln

2075 2080 2085

Asp Ser Ser Thr Pro Val Val Asn Ala Leu Asp Pro Pro Leu Phe

2090 2095 2100

Thr Arg Tyr Leu Arg Ile His Pro Thr Ser Trp Ala Gln His Ile

2105 2110 2115

Ala Leu Arg Leu Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr

2120 2125 2130

<210> 29

<211> 1466

<212> PRT

<213> Artificial sequence

<400> 29

Met Gln Leu Glu Leu Ser Thr Cys Val Phe Leu Cys Leu Leu Pro Leu

1 5 10 15

Gly Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser

20 25 30

Trp Asp Tyr Arg Gln Ser Glu Leu Leu Arg Glu Leu His Val Asp Thr

35 40 45

Arg Phe Pro Ala Thr Ala Pro Gly Ala Leu Pro Leu Gly Pro Ser Val

50 55 60

Leu Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Ser

65 70 75 80

Val Ala Arg Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile

85 90 95

Gln Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Met Ala

100 105 110

Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Phe Trp Lys Ser

115 120 125

Ser Glu Gly Ala Glu Tyr Glu Asp His Thr Ser Gln Arg Glu Lys Glu

130 135 140

Asp Asp Lys Val Leu Pro Gly Lys Ser Gln Thr Tyr Val Trp Gln Val

145 150 155 160

Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr

165 170 175

Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu

180 185 190

Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Arg Glu Arg

195 200 205

Thr Gln Asn Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu

210 215 220

Gly Lys Ser Trp His Ser Ala Arg Asn Asp Ser Trp Thr Arg Ala Met

225 230 235 240

Asp Pro Ala Pro Ala Arg Ala Gln Pro Ala Met His Thr Val Asn Gly

245 250 255

Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser

260 265 270

Val Tyr Trp His Val Ile Gly Met Gly Thr Ser Pro Glu Val His Ser

275 280 285

Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg His His Arg Gln Ala

290 295 300

Ser Leu Glu Ile Ser Pro Leu Thr Phe Leu Thr Ala Gln Thr Phe Leu

305 310 315 320

Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His His

325 330 335

His Gly Gly Met Glu Ala His Val Arg Val Glu Ser Cys Ala Glu Glu

340 345 350

Pro Gln Leu Arg Arg Lys Ala Asp Glu Glu Glu Asp Tyr Asp Asp Asn

355 360 365

Leu Tyr Asp Ser Asp Met Asp Val Val Arg Leu Asp Gly Asp Asp Val

370 375 380

Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr

385 390 395 400

Trp Val His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro

405 410 415

Ala Val Pro Ser Pro Ser Asp Arg Ser Tyr Lys Ser Leu Tyr Leu Asn

420 425 430

Ser Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Ala Arg Phe Val

435 440 445

Ala Tyr Thr Asp Val Thr Phe Lys Thr Arg Lys Ala Ile Pro Tyr Glu

450 455 460

Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu

465 470 475 480

Leu Ile Ile Phe Lys Asn Lys Ala Ser Arg Pro Tyr Asn Ile Tyr Pro

485 490 495

His Gly Ile Thr Asp Val Ser Ala Leu His Pro Gly Arg Leu Leu Lys

500 505 510

Gly Trp Lys His Leu Lys Asp Met Pro Ile Leu Pro Gly Glu Thr Phe

515 520 525

Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp

530 535 540

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Ser Ile Asn Leu Glu Lys

545 550 555 560

Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu

565 570 575

Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val

580 585 590

Ile Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Leu Ala Glu

595 600 605

Asn Ile Gln Arg Phe Leu Pro Asn Pro Asp Gly Leu Gln Pro Gln Asp

610 615 620

Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val

625 630 635 640

Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp

645 650 655

Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe

660 665 670

Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr

675 680 685

Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro

690 695 700

Gly Leu Trp Val Leu Thr Cys His Asn Ser Asp Leu Arg Asn Arg Gly

705 710 715 720

Met Thr Ala Leu Leu Lys Val Tyr Ser Cys Asp Arg Asp Ile Gly Asp

725 730 735

Tyr Tyr Asp Asn Thr Tyr Glu Asp Ile Pro Gly Phe Leu Leu Ser Gly

740 745 750

Lys Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg Pro Pro

755 760 765

Ser Ala Ser Ala Pro Lys Pro Pro Val Leu Arg His Gln Arg Asp Ile

770 775 780

Ser Leu Pro Thr Arg Gln Pro Glu Glu Asp Lys Met Asp Tyr Asp Asp

785 790 795 800

Ile Phe Ser Thr Glu Thr Lys Gly Glu Asp Phe Asp Ile Tyr Gly Glu

805 810 815

Asp Glu Asn Gln Asp Pro Arg Ser Phe Gln Lys Arg Thr Arg His Tyr

820 825 830

Phe Ile Ala Ala Val Glu Gln Leu Trp Asp Tyr Gly Met Ser Glu Ser

835 840 845

Pro Arg Ala Leu Arg Asn Arg Ala Gln Asn Gly Glu Val Pro Arg Phe

850 855 860

Lys Lys Val Val Phe Arg Glu Phe Ala Asp Gly Ser Phe Thr Gln Pro

865 870 875 880

Ser Tyr Arg Gly Glu Leu Asn Lys His Leu Gly Leu Leu Gly Pro Tyr

885 890 895

Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Lys Asn Gln

900 905 910

Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Pro Asp

915 920 925

Asp Gln Glu Gln Gly Ala Glu Pro Arg His Asn Phe Val Gln Pro Asn

930 935 940

Glu Thr Arg Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr

945 950 955 960

Glu Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp

965 970 975

Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys

980 985 990

Arg Ala Asn Thr Leu Asn Ala Ala His Gly Arg Gln Val Thr Val Gln

995 1000 1005

Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp

1010 1015 1020

Tyr Phe Thr Glu Asn Val Glu Arg Asn Cys Arg Ala Pro Cys His

1025 1030 1035

Leu Gln Met Glu Asp Pro Thr Leu Lys Glu Asn Tyr Arg Phe His

1040 1045 1050

Ala Ile Asn Gly Tyr Val Met Asp Thr Leu Pro Gly Leu Val Met

1055 1060 1065

Ala Gln Asn Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser

1070 1075 1080

Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Ser

1085 1090 1095

Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Val Tyr Asn Leu Tyr

1100 1105 1110

Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Val Gly

1115 1120 1125

Ile Trp Arg Ile Glu Cys Leu Ile Gly Glu His Leu Gln Ala Gly

1130 1135 1140

Met Ser Thr Thr Phe Leu Val Tyr Ser Lys Glu Cys Gln Ala Pro

1145 1150 1155

Leu Gly Met Ala Ser Gly Arg Ile Arg Asp Phe Gln Ile Thr Ala

1160 1165 1170

Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His

1175 1180 1185

Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Asp Pro His Ser

1190 1195 1200

Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile

1205 1210 1215

Met Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser

1220 1225 1230

Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Arg Asn Trp Gln Ser

1235 1240 1245

Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn

1250 1255 1260

Val Asp Ala Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile

1265 1270 1275

Val Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg

1280 1285 1290

Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys

1295 1300 1305

Ser Met Pro Leu Gly Met Gln Asn Lys Ala Ile Ser Asp Ser Gln

1310 1315 1320

Ile Thr Ala Ser Ser His Leu Ser Asn Ile Phe Ala Thr Trp Ser

1325 1330 1335

Pro Ser Gln Ala Arg Leu His Leu Gln Gly Arg Thr Asn Ala Trp

1340 1345 1350

Arg Pro Arg Val Ser Ser Ala Glu Glu Trp Leu Gln Val Asp Leu

1355 1360 1365

Gln Lys Thr Val Lys Val Thr Gly Ile Thr Thr Gln Gly Val Lys

1370 1375 1380

Ser Leu Leu Ser Ser Met Tyr Val Lys Glu Phe Leu Val Ser Ser

1385 1390 1395

Ser Gln Asp Gly Arg Arg Trp Thr Leu Phe Leu Gln Asp Gly His

1400 1405 1410

Thr Lys Val Phe Gln Gly Asn Gln Asp Ser Ser Thr Pro Val Val

1415 1420 1425

Asn Ala Leu Asp Pro Pro Leu Phe Thr Arg Tyr Leu Arg Ile His

1430 1435 1440

Pro Thr Ser Trp Ala Gln His Ile Ala Leu Arg Leu Glu Val Leu

1445 1450 1455

Gly Cys Glu Ala Gln Asp Leu Tyr

1460 1465

Claims (9)

1. A nucleic acid encoding a variant Gly710Thr of a highly active factor viii or villa polypeptide, wherein:

(1) hF VIII cDNA: the nucleotide sequence is shown in any one of SEQ ID NO 1-4;

or (2) BDD hFVIII-SQ: the nucleotide sequence is shown as any one of SEQ ID NO 5-8;

or (3) BDD hFVIII-N8: the nucleotide sequence is shown in any one of SEQ ID NO 9-12;

or (4) BDD hFVIII-SC: the nucleotide sequence is shown in any one of SEQ ID NO 13-16;

or (5) BDDhFVIII- Δ F: the nucleotide sequence is shown in any one of SEQ ID NO 17-20.

2. A mutein of highly active factor VIII or VIIIa polypeptide variant Gly710Thr characterized in that: the amino acid sequence is shown in any one of SEQ ID NO 21-29, and the 710th amino acid of the mutant is Thr instead of Gly of wild type VIII or VIII a.

3. A nucleic acid encoding the mutein of claim 2 or a nucleic acid of the same length as the encoding nucleic acid and being completely complementary to the encoding nucleic acid.

4. A vector expressing the mutein of claim 2.

5. A method for preparing a mutant protein of a high-activity blood coagulation factor VIII or VIIIa polypeptide variant Gly710Thr, which comprises the following steps:

BDD-hFVIII or full-length FVIII is taken as a template, a PCR site-directed mutagenesis method is used for introducing mutation sites into wild FVIII, Gly710 amino acid residues are replaced by Thr, and BDD-hFVIII or full-length FVIII eukaryotic expression plasmids which are correctly inserted into Gly710Thr mutation are screened after transformation.

6. Use of a nucleic acid encoding a mutein of a highly active factor viii or villia polypeptide variant Gly710Thr, wherein: use of the nucleic acid of claim 1 or 3 for the preparation of a gene therapy drug comprising linking it to promoter and termination sequences to construct an expression plasmid, gene therapy viral or non-viral vector expressing the mutein of claim 2.

7. The use of a mutein of highly active factor viii or villa polypeptide variant Gly710Thr according to claim 2 wherein: is applied to preparing the recombinant protein therapeutic drug for hemophilia.

8. The use of a mutein of highly active factor viii or villa polypeptide variant Gly710Thr according to claim 2 wherein: the fusion protein is applied to preparing the fusion protein of the polypeptide variant Gly710Thr mutant of the blood coagulation factor VIII or VIII a, and the fusion protein is used for preparing the recombinant protein therapeutic drug for hemophilia.

9. Use according to claim 8, characterized in that: the fusion protein is obtained by fusing one of human albumin, immunoglobulin Fc, transferrin or alpha 1 antitrypsin with the mutant protein of the polypeptide variant Gly710Thr mutant of the blood coagulation factor VIII or VIII a.

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