CN114713098A - Micro-fluidic nano-pharmaceutical system - Google Patents
Micro-fluidic nano-pharmaceutical system Download PDFInfo
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- CN114713098A CN114713098A CN202210216224.0A CN202210216224A CN114713098A CN 114713098 A CN114713098 A CN 114713098A CN 202210216224 A CN202210216224 A CN 202210216224A CN 114713098 A CN114713098 A CN 114713098A
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- 239000007788 liquid Substances 0.000 claims abstract description 66
- 238000002347 injection Methods 0.000 claims abstract description 22
- 239000007924 injection Substances 0.000 claims abstract description 22
- 230000009471 action Effects 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 abstract description 19
- 239000002994 raw material Substances 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 5
- 238000010586 diagram Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000012362 drug development process Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
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- 239000002086 nanomaterial Substances 0.000 description 1
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- 239000011550 stock solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
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Abstract
The invention discloses a micro-fluidic nano-pharmaceutical system, which belongs to the technical field of nano-pharmaceuticals and comprises a chip module, wherein the chip module comprises a chip body; the output port of the liquid injection equipment is hermetically connected with the liquid inlet on the chip body; the output port of the liquid receiving equipment is hermetically connected with the liquid outlet on the chip body; the first driving module is used for controlling the action of the liquid injection equipment; the second driving module is used for controlling the action of the liquid receiving equipment; and a control module. The first driving module and the second driving module respectively control the action of the liquid injection device and the liquid receiving device, and raw materials are mixed in the chip module, so that the preparation of a sample is completed, the continuous preparation of the sample is realized, and the control module controls the action of the first driving module and the second driving module, so that the preparation of the sample has reproducibility.
Description
Technical Field
The invention belongs to the technical field of nano-scale pharmacy, and particularly relates to a microfluidic nano-scale pharmacy system.
Background
In all links from diagnosis, treatment to prognostic treatment, a suitable way is sought to realize accurate medical treatment. Among them, nano-drugs using nano-materials as carriers in the drug development process are becoming a new favorite in the pharmaceutical field, affecting the original drug development mode, and bringing about an accurate delivery mode. The nanometer medicine taking the nanometer material as the carrier is improving human health, the COVID-9 virus outbreak in the world at this time, and the nanometer medicine makes outstanding contribution to the development of vaccines.
Most of the existing nano-pharmaceutical equipment is realized based on a micro-fluidic chip, and the preparation of a sample is realized through the chip, but the existing preparation steps are split, for example, a droplet collection device based on the micro-fluidic chip is disclosed in the publication No. CN105396632B, and starting from the collection steps, the preparation of medicines does not have continuity, and related parameters are uncontrollable and have no reproducibility.
Disclosure of Invention
The present invention aims at providing a microfluidic nano-pharmaceutical system to solve the problems of the prior art in the use process.
In order to achieve the purpose, the invention provides the following technical scheme: a microfluidic nano-pharmaceutical system comprising a chip module, the chip module comprising a chip body;
the output port of the liquid injection equipment is hermetically connected with the liquid inlet on the chip body;
the output port of the liquid receiving equipment is hermetically connected with the liquid outlet on the chip body;
the first driving module is used for controlling the action of the liquid injection equipment;
the second driving module is used for controlling the action of the liquid receiving equipment;
and the control module is used for controlling the first driving module and the second driving module.
Preferably, the first driving module comprises a plurality of first sub-driving modules, and the number of the first sub-driving modules is matched with the number of the liquid inlets.
Preferably, the second driving module comprises a plurality of second sub-driving modules, and the number of the second sub-driving modules is matched with the number of the liquid outlets.
Preferably, the liquid injection equipment is an injector, and the liquid injection equipment is in threaded connection with the liquid inlet.
Preferably, the first sub-driving module includes a ball screw, a first motor for driving the ball screw to move, and an adaptor fixedly connected to the ball screw and the nut pair.
Preferably, the first motor is a servo motor or a stepping motor.
Preferably, the first sub-driving module is a linear guide device.
Preferably, the liquid receiving device is a sample tube.
Preferably, the second sub-driving module comprises a second motor, a gear connected to an output end of the second motor, and a rack engaged with the gear, and the liquid collecting device is fixedly connected with the rack.
Preferably, the second sub-driving module is a linear guide device.
Compared with the prior art, the invention has the beneficial effects that:
the action of annotating liquid equipment and receipts liquid equipment is controlled respectively through first drive module and second drive module, and the raw materials mixes in the chip module to accomplish the preparation of sample, and then realize the serialization preparation of sample, through the action of first drive module of control module control and second drive module, can control the addition amount and the speed of raw materials, and then realize the accurate of sample preparation, make the preparation of sample have the reproducibility simultaneously.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic structural diagram of a first driving module according to the present invention;
FIG. 3 is a schematic structural diagram of a second driving module according to the present invention;
fig. 4 is a schematic structural diagram of an embodiment of the present invention.
In the figure: 10. a chip module; 110. a chip body; 110a and a liquid inlet; 110b, a liquid outlet; 20. liquid injection equipment; 30. liquid collecting equipment; 40. a first driving module; 400. a first sub-driving module; 400a, a first motor; 400b, a ball screw; 400c, an adapter; 50. a second driving module; 500. a second sub-driving module; 500a, a second motor; 500b, a gear; 500c, a rack; 60. and a control module.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-4, the present invention provides a technical solution: the utility model provides a micro-fluidic nano-scale pharmacy system, includes chip module 10, and chip module 10 includes chip body 110, is equipped with a plurality of inlets 110a and liquid outlet 110b on the chip body 110, and inlet 110a is used for and is connected with outside notes liquid equipment 20, and liquid outlet b position is equipped with receipts liquid equipment 30 simultaneously, and through control notes liquid equipment 20 and receipts liquid equipment 30 action, makes liquid mix in the chip, and then accomplishes the preparation and the collection operation of sample.
The pharmaceutical system further comprises a first driving module 40 for controlling the action of the liquid injection device 20, a second driving module 50 for controlling the operation of the liquid receiving device 30 and a control module 60 for controlling the operation of the first driving module 40 and the second driving module 50, wherein the first driving module 40 and the second driving module 50 respectively comprise a plurality of first sub-driving modules 400 and second sub-driving modules 500, the number of the first sub-driving modules 400 and the number of the second sub-driving modules 500 are respectively matched with the number of the liquid injection device 20 and the number of the liquid receiving device 30, the control system selectively starts the corresponding first sub-driving modules 400 and second sub-driving modules 500 according to raw materials required by sample preparation, controls the corresponding first sub-driving modules 400 to act according to the proportion corresponding to the raw materials, further controls the addition amount of the raw materials corresponding to the liquid injection device 20, realizes the accurate and continuous addition of the raw materials, the added raw materials are mixed in a flow channel in the chip body 110, and then the preparation of the sample is completed, the preparation of different samples can be realized by changing the parameters of the control system, and meanwhile, the parameters in the control system can be controlled, so that the preparation of the sample has reproducibility.
Further, the liquid injection device 20 is a syringe, and an output port of the syringe is hermetically connected to the liquid inlet 110a of the chip body 110.
The first sub-driving module 400 adapted to the injector is a driving mechanism for pushing the piston of the injector to perform linear motion, and in order to realize accurate control of the injection amount, the first sub-driving module comprises a first motor 400a, a ball screw 400b and an adapter 400c, wherein the adapter 400c is fixedly connected to a nut pair of the ball screw 400b and performs linear motion along the length direction of the screw along with the nut pair, the first motor 400a is preferably a stepping motor or a servo motor, which can further improve the control accuracy, and meanwhile, the first motor 400a is connected with the ball screw 400b through a coupling, which can improve the stability of the device during operation, the first motor 400a drives the screw on the ball screw 400b to rotate, and the nut pair on the screw performs linear motion along the length direction of the screw along with the rotation of the screw, and then the adaptor 400c is driven to move and push the piston in the injector to move in the injector, thereby completing the injection operation.
Furthermore, the lead and the precision of the ball screw 400b can be freely selected, a worker can select the ball screw 400b with the proper lead and precision according to the injection amount, calculate the injection amount in the unit displacement amount by combining the specification of the injector, and control the operation of the first motor 400a through the control module 60 (which can be a PLC or a single chip microcomputer), thereby realizing the control of the addition amount of the raw material.
Further, the first sub-driving module 400 is a linear guide device.
Further, the liquid collecting device 30 is a sample tube, and a second sub-driving system used in cooperation with the sample tube is also a linear driving system, preferably, the second sub-driving system includes a second motor 500a, a gear 500b connected to an output end of the second motor 500a, and a rack 500c engaged with the gear 500b, wherein the sample tube is fixed on the rack 500c and linearly reciprocates along with the rack 500c, the gear 500b is driven by the second motor 500a to rotate, the rack 500c engaged with the gear 500b linearly moves along with the rotation of the gear 500b, the movement of the sample tube and the movement of the rack 500c are synchronous, when preparing the sample, an opening of the sample tube faces the liquid outlet b of the chip body 110 to collect the sample, after the sample collection is completed, the sample tube moves to a recovery position along with the rack 500c, and after the worker recovers the sample in the sample tube, the second motor 500a is restarted, and the idle sample tube moves along with the rack 500c and returns to the position of the liquid outlet b of the chip body 110 again to continue the sample collection operation.
Further, the second sub-driving module 500 may also be a pneumatic device or a linear guide device.
The working principle and the using process of the invention are as follows:
assuming that the number of the liquid inlets 110a on the chip body 110 is two, the liquid inlets are respectively located on two sides of the symmetrical plane of the chip body 110, the number of the liquid outlets b is one, the liquid injection device 20 is an injector, which is marked as a first injector and a second injector, and the liquid receiving device 30 is a sample tube, when in use, firstly, raw materials required for sample preparation are added into the first injector and the second injector, then, output ports of the first injector and the second injector are respectively connected with the two liquid inlets 110b on the chip body 110, after the device connection is completed, parameters of the control module 60 are set corresponding to the parameters of the sample preparation, and the first motor 400a is started through the control module 60, so as to drive the nut pair on the ball screw 400b and the adapter 400c fixedly connected with the nut pair to perform linear motion, so as to drive the piston of the injector to perform linear motion to complete liquid injection operation, the stock solution injected by the first injector and the second injector is mixed in the flow channel in the chip body 110, the sample prepared by mixing flows out from the liquid outlet b on the chip body 110 and enters the sample tube, after the sample preparation with the set amount is finished, the second motor 500a in the second sub-drive module 500 is started, the second motor 500a drives the gear 500b to rotate, further, the rack 500c and the sample tube are driven to move to the collection area, after the sample collection is finished, the sample tube returns to the position of the liquid outlet b again under the drive of the second sub-drive module 500, and the next round of sample preparation is carried out according to the parameters of the control system.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A microfluidic nano-pharmaceutical system, characterized in that: comprises that
A chip module (10), the chip module (10) comprising a chip body (110);
the output port of the liquid injection device (20) is hermetically connected with the liquid inlet on the chip body (110);
the output port of the liquid receiving equipment (30) is hermetically connected with the liquid outlet on the chip body (110);
a first driving module (40) for controlling the action of the liquid injection device (20);
a second driving module (50) for controlling the liquid receiving equipment (30) to act;
a control module (60), the control module (60) for controlling the first drive module (40) and the second drive module (50).
2. The microfluidic nano-pharmaceutical system of claim 1, wherein: the first driving module (40) comprises a plurality of first sub-driving modules (400), and the number of the first sub-driving modules (400) is matched with the number of the liquid inlets.
3. The microfluidic nano-pharmaceutical system of claim 1, wherein: the second driving module (50) comprises a plurality of second sub-driving modules (500), and the number of the second sub-driving modules (500) is matched with the number of the liquid outlets.
4. The microfluidic nano-pharmaceutical system of claim 1, wherein: the liquid injection equipment (20) is an injector, and the liquid injection equipment (20) is in threaded connection with the liquid inlet.
5. The microfluidic nano-pharmaceutical system according to claim 4, wherein: the first sub-driving module (400) comprises a ball screw (400b), a first motor (400a) driving the ball screw (400b) to move and an adapter (400c) fixedly connected with a nut pair on the ball screw (400 b).
6. The microfluidic nano-pharmaceutical system of claim 5, wherein: the first motor (400a) is a servo motor or a stepping motor.
7. The microfluidic nano-pharmaceutical system of claim 2, wherein: the first sub-driving module (400) is a linear guide device.
8. The microfluidic nano-pharmaceutical system of claim 1, wherein: the liquid receiving equipment (30) is a sample tube.
9. The microfluidic nano-pharmaceutical system of claim 8, wherein: the second sub-driving module (500) comprises a second motor (500a), a gear (500b) connected to the output end of the second motor (500a) and a rack (500c) meshed with the gear (500b), and the liquid collecting device (30) is fixedly connected with the rack (500 c).
10. The microfluidic nano-pharmaceutical system of claim 3, wherein: the second sub-driving module (500) is a linear guide device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210216224.0A CN114713098A (en) | 2022-03-07 | 2022-03-07 | Micro-fluidic nano-pharmaceutical system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210216224.0A CN114713098A (en) | 2022-03-07 | 2022-03-07 | Micro-fluidic nano-pharmaceutical system |
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| CN114713098A true CN114713098A (en) | 2022-07-08 |
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| CN202210216224.0A Pending CN114713098A (en) | 2022-03-07 | 2022-03-07 | Micro-fluidic nano-pharmaceutical system |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203625357U (en) * | 2013-11-15 | 2014-06-04 | 上海康微健康科技有限公司 | Circulating tumor cell separation system |
| CN208757614U (en) * | 2018-06-21 | 2019-04-19 | 仲恺农业工程学院 | Distributing mechanism and synthesis system based on dielectric wetness technique |
| CN111389281A (en) * | 2020-05-15 | 2020-07-10 | 于海 | Microfluidic hybrid chip box for parallel high-throughput nanoparticle generation |
-
2022
- 2022-03-07 CN CN202210216224.0A patent/CN114713098A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203625357U (en) * | 2013-11-15 | 2014-06-04 | 上海康微健康科技有限公司 | Circulating tumor cell separation system |
| CN208757614U (en) * | 2018-06-21 | 2019-04-19 | 仲恺农业工程学院 | Distributing mechanism and synthesis system based on dielectric wetness technique |
| CN111389281A (en) * | 2020-05-15 | 2020-07-10 | 于海 | Microfluidic hybrid chip box for parallel high-throughput nanoparticle generation |
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