CN114699987A - Manufacturing device for flaky sulfo aliphatic new material - Google Patents

Manufacturing device for flaky sulfo aliphatic new material Download PDF

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Publication number
CN114699987A
CN114699987A CN202210451469.1A CN202210451469A CN114699987A CN 114699987 A CN114699987 A CN 114699987A CN 202210451469 A CN202210451469 A CN 202210451469A CN 114699987 A CN114699987 A CN 114699987A
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China
Prior art keywords
roller
hot
heater
belt type
flaky
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CN202210451469.1A
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Chinese (zh)
Inventor
祝红元
汪家众
张欣
邵洪健
黄春杰
赵继民
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Jiangsu Youyang Pharmaceutical Co ltd
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Jiangsu Youyang Pharmaceutical Co ltd
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Priority to CN202210451469.1A priority Critical patent/CN114699987A/en
Publication of CN114699987A publication Critical patent/CN114699987A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/18—Use of auxiliary physical effects, e.g. ultrasonics, irradiation, for disintegrating
    • B02C19/186—Use of cold or heat for disintegrating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B3/00—Presses characterised by the use of rotary pressing members, e.g. rollers, rings, discs
    • B30B3/04—Presses characterised by the use of rotary pressing members, e.g. rollers, rings, discs co-operating with one another, e.g. with co-operating cones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention relates to a manufacturing device of a sheet-shaped sulfoaliphatic new material, which comprises a soft plastic material preparation system, wherein the soft plastic material preparation system comprises a solid feeder, a slurry conveying pump and a mixing heater; the feed inlet of the mixing heater is respectively connected with a solid feeder and a slurry delivery pump, and the discharge outlet of the mixing heater is connected with a tabletting cooling system; the tabletting cooling system comprises an upper hot roller, a lower cold roller and a bottom pulp crushing conveyor; the bearings on the two sides of the hot roller are also provided with hydraulic devices, and the hot roller is pressed on the cold roller through the hydraulic devices; the lower part of the pulp crushing conveyor is connected with a hot air aging packaging system; the hot air aging packaging system comprises a belt type aging device, a fan, a heater, a vibrating screen and a storage bin; the belt type aging device is internally provided with a porous mesh belt which slowly and circularly moves inside; the fan, the heater and the belt type aging device are circularly connected; the side discharge port of the belt type aging device is connected with a vibrating screen, and the vibrating screen is connected with a storage bin.

Description

Manufacturing device for flaky sulfo aliphatic new material
Technical Field
The invention relates to a manufacturing device of a flaky sulfo aliphatic new material, which is particularly suitable for preparing pharmaceutic adjuvant flaky sodium dodecyl sulfate and flaky fatty acid methyl ester sulfonate.
Background
At present, sodium dodecyl sulfate and sodium fatty acid methyl ester sulfonate products in domestic and foreign markets are mainly in the forms of powder, long strips, beads or small particles. Typically, a slurry of 30% or 70% is used for drying and then forming. The drying form includes spray drying, film scraping drying, vacuum tube drying, etc. The molding equipment comprises an extruder, a flour mill, a shot blasting machine, a crusher and the like. The drying medium is hot air or steam, and the temperature is generally more than 100 ℃. Because the sodium dodecyl sulfate is a heat-sensitive substance, the rancidity of materials and the corrosion of metal materials are easily caused when the temperature is more than 100 ℃. Therefore, the above drying apparatus has various problems. For example, the spray drying production cycle is short, and the product is easy to generate black spots; the inner part of the film scraping and drying equipment is seriously corroded, and wearing parts such as scraping sheets, screws and the like need to be frequently replaced, so that metal ions are easily brought into products. The vacuum tube type drying also has the problems of pipeline blockage, corrosion and the like.
The flaky sulfoaliphatic new material and the flaky fatty acid Methyl Ester Sulfonate (MES) can be widely used for a medicine auxiliary material dispersant, a cosmetic emulsifier and a detergent. The product hygiene requirement is high, the whole production and packaging process must be strictly controlled, dust and foreign matters are prevented from entering the product, each package of product needs to be inspected, and the product cannot have impurities such as black spots, metal ions and the like. The safety is high, the use is convenient, and the use amount is increased year by year. The product is characterized in that the product is flaky, is firm and dust-free, has the thickness of less than 0.5mm and the outer diameter of less than 5mm, and can be directly used as a detergent.
The preparation of the sheet products in the pharmaceutical industry uses a dry granulator for production. The dry granulator consists of a screw conveyer, a compression roller, a crusher and the like. The dry powder is pressurized and conveyed between an upper compression roller and a lower compression roller by a screw conveyor to be extruded into a sheet shape, the distance and the pressure of the compression rollers are adjusted, the compactness of the sheet-shaped product is controlled, and finally a crushing knife is used for crushing. The finished product is directly obtained by the process, and the extrusion force of the compression roller can reach 10 MPa. The main defects are that 1, the pressure of a screw conveyor and a compression roller is large, the equipment manufacturing difficulty is large, and materials are easy to heat and are not beneficial to industrial production; 2. dry granulation uses dry powder for processing, and sodium dodecyl sulfate belongs to explosion-related dust and is easy to cause safety accidents; 3. the preparation of dry powder still uses the traditional process, and various problems are inevitable.
The drying and forming technology can prepare sodium dodecyl sulfate products, but the product quality cannot be further improved, and the problems of abnormal quality, dust and the like in the preparation process exist.
Disclosure of Invention
The invention aims to provide a manufacturing device of a flaky sulfoaliphatic new material aiming at the defects of the existing manufacturing process and manufacturing equipment. The process is flexible, the product has low critical water content, is dried at low temperature, does not have the problems of acid reversal, black spots and the like, and is suitable for the production of high-quality sodium dodecyl sulfate with few batches and various pharmaceutical adjuvant grades, cosmetic grades and the like.
The technical scheme adopted by the invention is as follows:
a manufacturing device of a flaky sulfoaliphatic new material comprises a soft plastic material preparation system, a tabletting cooling system and a hot air aging packaging system; the soft plastic material preparation system comprises a solid feeder, a slurry delivery pump and a mixing heater; the feed inlet of the mixing heater is respectively connected with the solid feeder and the slurry delivery pump, and the discharge outlet is connected with the tabletting cooling system.
The tabletting cooling system comprises an upper hot roller, a lower cold roller and a bottom pulp crushing conveyor; the bearings on the two sides of the hot roller are also provided with hydraulic devices, and the hot roller is pressed on the cold roller through the hydraulic devices; the lower part of the pulp crushing conveyor is connected with a hot air aging packaging system.
And a water inlet pipe and a water outlet pipe are respectively arranged at the center of the hot roller and the center of the cold roller, and a plurality of spray heads are arranged on the water inlet pipe. In the hot roller, hot water flows to the shower nozzle from the inlet pipe to evenly spout and shine and keep hot roller surface high temperature inside the barrel, keep the soft characteristic of material and be favorable to the extrusion to form the piece, then hot water flows from the outlet pipe. In the cold roller, cold water flows to the spray head from the water inlet pipe, the cold water is uniformly sprayed in the cylinder body to keep the outer surface of the cold roller at low temperature, so that the soft material is cooled and solidified on the surface, and the cold water after heat exchange flows out from the water outlet pipe.
The hot air aging packaging system comprises a belt type aging device, a fan, a heater, a vibrating screen and a storage bin; a porous mesh belt is arranged in the belt type aging device and slowly and circularly moves in the belt type aging device; the fan, the heater and the belt type aging device are connected in a circulating manner; the side discharge port of the belt type aging device is connected with a vibrating screen, and the vibrating screen is connected with a storage bin.
The mixing heater is externally provided with a hot water jacket.
The soft plastic hot material is prepared by mixing and heating solid and slurry lauryl sodium sulfate, wherein the concentration of the slurry is 65-75 percent of lauryl sodium sulfate; heating at 60-90 deg.c; the concentration of the soft plastic material is 85-95 percent of lauryl sodium sulfate.
After the technical scheme is adopted, the invention has the beneficial effects that:
1. the physical form is good. The product is in the shape of small flake, and has less dust, low density and large specific surface area.
2. The process is flexible and simple. Is suitable for the production of pharmaceutic adjuvants.
3. The production process is high in safety.
4. The product has low impurity content and no metal corrosion and acid reaction.
Drawings
FIG. 1 is a schematic view of the connection of the apparatus of the present invention.
FIG. 2 is a schematic diagram of the configuration of the sheeting cooling system of the present invention.
In the figure:
(1) the soft plastic material preparation system comprises: 1-a solid feeder, 2-a slurry delivery pump, 3-a mixing heater and 31-a heating jacket;
(2) the tablet cooling system 4 includes: 41-hot roller, 42-cold roller, 43-pulp crushing conveyor and 44-hydraulic device; a-a hydraulic pump, b-a pressure stabilizing tube, c-a hydraulic hose, d-a piston, e-a pressure lever, f-a bolt and g-a bracket;
(3) the hot air aging packaging system comprises: 5-belt type aging machine, 51-fan, 52-heater, 53-porous mesh belt, 6-vibrating screen and 7-storage bin.
Detailed Description
The invention will be further described with reference to the accompanying drawings.
Example 1
As shown in fig. 1: a manufacturing device and a production process of a novel flaky sulfo aliphatic material comprise a soft plastic material preparation system, a tabletting cooling system and a hot air aging packaging system. The soft plastic material preparation system mainly aims at preparing soft materials which are easy to tablet for a tablet press and are convenient to press into thin slices for cooling. Mainly comprises a solid feeder 1, a slurry delivery pump 2 and a mixing heater 3; the outside of the mixing heater 3 is provided with a hot water jacket 31 for heating internal materials, a feed inlet is connected with a solid feeder 1 and a slurry delivery pump 2, and solid and slurry lauryl sodium sulfate are conveyed to a tabletting cooling system 4 from a discharge port in a soft plastic material state after passing through the mixing heater 3.
The tabletting cooling system 4 is mainly used for pressing the soft plastic material into thin slices in a hot state, and then cooling the thin slices to be crisp and cut into small pieces in a cold state. Mainly comprising an upper hot roll 41, a lower cold roll 42 and a bottom paddle-breaker conveyor 43. The hot-rolling device is characterized in that a water inlet pipe and a water outlet pipe are installed in the center of the hot roller, a plurality of spray heads are installed on the water inlet pipe, hot water is sprayed out to heat the hot-rolling roller, and the hot water is kept at a certain temperature to prevent the soft sodium dodecyl sulfate from hardening and being incapable of tabletting. Hydraulic devices 44 are further installed on bearings on both sides of the heat roller, and press the heat roller against the cold roller through the hydraulic devices while controlling the pressure between the heat roller 41 and the cold roller. The soft sodium dodecyl sulfate material is conveyed between the cold roller 42 and the hot roller, and because the hot roller 41 and the cold roller 42 are mutually pressed and relatively rotate, the soft material is pressed upwards by the hot roller to be thinned, is cooled downwards by the cold roller, is finally pressed into thin slices to be adhered to the surface of the cold roller 42, and becomes brittle after cooling. The cold roll center is installed inlet tube and outlet pipe, install a plurality of shower nozzles on the inlet tube, the cooling water passes through shower nozzle evenly distributed on the cold roll barrel, transmits the material surface again. The cold roller 42 is positioned below the hot roller 41, and the lower part of the cold roller 42 is connected with a paddle type crushing conveyor 43. The cooled flakes eventually fall to a bottom paddle-breaker conveyor 43 and are transported in chip form to a hot air aging packaging system.
As shown in fig. 2, the hydraulic device consists of a hydraulic pump a, a buffer tank b, a hydraulic pipe c, a piston d and a pressure rod e; the outlet of the hydraulic pump a is connected with a hydraulic pipe c through threads, and a buffer tank b is arranged on a bypass; the other end of the hydraulic pipe is connected with an oil inlet of the piston d through threads; the lower end of the piston is provided with a pressing rod e, the piston is pushed by hydraulic pressure to enable the hot roller 41 to move downwards and press at a fixed position, the hot roller 41 is tightly pressed on the cold roller 42, and a certain pressure is kept. The hot-rolling machine is characterized in that fixing supports g are arranged at two ends of the hot-rolling 41, each support is connected with two bolts f through threads, and the hot-rolling is installed on the supports g through the bolts f and can move up and down along the bolt direction. The heat roller 41 is fixed at one position by a pressing rod e.
The hot air aging packaging system mainly aims to age the flaky sulfoaliphatic new material by hot air to remove part of volatile matters, so that the product quality is uniform and stable. Mainly comprises a belt type aging device 5, a fan 51, a heater 52, a vibrating screen 6 and a storage bin 7. The inside of the belt type aging device 5 is provided with a porous mesh belt 53 which slowly circulates, hot air is pressurized by a fan 51, after the temperature of a heater 52 is raised, the hot air is uniformly sent into the belt type aging device 5 from the lower part, and is heated by the contact of the porous mesh belt and sodium dodecyl sulfate, part of volatile matters in the sodium dodecyl sulfate are taken away with the hot air, flow out from the top of the belt type aging device 5 and then return to the fan 51 to form hot air circulation. The aging effect is controlled by temperature, bed thickness, time and the like. Discharging the aged sodium dodecyl sulfate from a side discharge hole, conveying the sodium dodecyl sulfate to a vibrating screen 6 for screening, and then removing a storage bin 7 for packaging.
The working principle is as follows:
principle of system for preparing sodium dodecyl sulfate soft plastic material
The material is regulated to be soft and plastic by two factors of the moisture content and the temperature of the material. Firstly, solid sodium dodecyl sulfate and slurry sodium dodecyl sulfate are stirred and mixed into a soft material with the concentration of 85-95%. Heating the materials while stirring and mixing, and keeping for a certain time to heat the materials to a certain temperature to form the soft plastic material.
Principle of (II) tabletting cooling system
The mechanism that the material becomes soft and easy to be tabletted when heated at temperature and becomes brittle and tabletted when the temperature is reduced is utilized. The soft plastic material is firstly sent between a cold roller and a hot roller, the hot roller is heated to keep the upper surface of the material to be soft plastic, and the cold roller is cooled to make the material become brittle. The higher pressure is kept through a hydraulic device, the flaky materials passing through the double rollers are stuck on the cold roller in a certain thickness, and the thinner the materials, the better the cooling effect. Finally, the sheet sodium dodecyl sulfate falls into a slurry crushing conveyor to be cut into small pieces.
(III) Hot air aging packaging system principle
The temperature of the sodium dodecyl sulfate tablet is raised by utilizing hot air, part of volatile matters in the platelet sulfoaliphatic new material are vaporized along with the hot air, and the aging is carried out for a certain time and temperature to remove part of volatile matters, so that the product quality is uniform and stable. The inside of the belt type aging device is provided with a porous mesh belt which slowly circulates and moves inside, hot air is pressurized by a fan, the heated air is uniformly fed from the lower part of the belt type aging device after being heated by a heater, the heated air is contacted and heated by the porous mesh belt and the sodium dodecyl sulfate, part of volatile matters in the sodium dodecyl sulfate are taken away with hot air, and the volatile matters flow out from the top of the belt type aging device 5 and then return to the fan 51 to form hot air circulation. The aging effect is controlled by temperature, bed thickness, time and the like.
Example 2
The apparatus for producing a novel flaky sulfoaliphatic material as described in example 1 was used.
First step, preparation of Soft Plastic Material
1000kg of powdery solid sodium lauryl sulfate (water content: 1.5%) and 300kg of sodium lauryl sulfate slurry (water content: 30%) were mixed and heated to 1300kg of sodium lauryl sulfate containing 8.1% water at 60 ℃.
Second, cooling the tablets
The temperature of the hot roller is 40 ℃, the temperature of the cold roller is 15 ℃, and then the mixture is crushed into small pieces to prepare the lauryl sodium sulfate tablet with the temperature of about 25 ℃.
Third, aging with hot air
The small flake-shaped materials from the second step are aged at 80 ℃ and the air volume of 5000m3H, 2 hours, 1200kg of final product, 2.5% water content.

Claims (4)

1. An apparatus for producing a flaky sulfoaliphatic new material, comprising: comprises a soft plastic material preparation system, a tabletting and cooling system and a hot air aging and packaging system; the soft plastic material preparation system comprises a solid feeder (1), a slurry delivery pump (2) and a mixing heater (3); the feed port of the mixing heater is respectively connected with a solid feeder (1) and a slurry delivery pump (2), and the discharge port of the mixing heater is connected with a tabletting cooling system (4);
the tabletting cooling system (4) comprises an upper hot roller (41), a lower cold roller (42) and a bottom paddle crushing conveyor (43); the bearings at the two sides of the hot roller are also provided with hydraulic devices (44) which press the hot roller on the cold roller; the lower part of the pulp crushing conveyor (43) is connected with a hot air aging packaging system;
the hot air aging packaging system comprises a belt type aging device (5), a fan (51), a heater (52), a vibrating screen (6) and a storage bin (7); the belt type aging device (5) is internally provided with a porous mesh belt (53) which slowly and circularly moves; the fan (51), the heater (52) and the belt type aging device (5) are connected in a circulating manner; the side discharge port of the belt type aging device 5 is connected with a vibrating screen (6), and the vibrating screen (6) is connected with a stock bin (7).
2. The apparatus for producing a novel material for a flaky sulfoaliphatic material according to claim 1, wherein: the outside of the mixing heater (3) is provided with a hot water jacket (31).
3. The apparatus for producing a novel material for a flaky sulfoaliphatic material according to claim 1, wherein: the hot roller center and the cold roller center are respectively provided with a water inlet pipe and a water outlet pipe, and the water inlet pipe is provided with a plurality of nozzles.
4. The apparatus for producing a novel material for a flaky sulfoaliphatic material according to claim 1, wherein: the hydraulic device consists of a hydraulic pump (a), a buffer tank (b), a hydraulic pipe (c), a piston (d) and a pressure lever (e); the outlet of the hydraulic pump (a) is connected with a hydraulic pipe (c) through threads, and a buffer tank (b) is arranged on a bypass; the other end of the hydraulic pipe is connected with an oil inlet of the piston (d) through threads; and a pressure rod (e) is arranged at the lower end of the piston.
CN202210451469.1A 2022-04-27 2022-04-27 Manufacturing device for flaky sulfo aliphatic new material Pending CN114699987A (en)

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CN202210451469.1A CN114699987A (en) 2022-04-27 2022-04-27 Manufacturing device for flaky sulfo aliphatic new material

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Application Number Priority Date Filing Date Title
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Publication number Priority date Publication date Assignee Title
JPS55100415A (en) * 1979-01-26 1980-07-31 Nippon Valqua Ind Ltd Manufacturing method of asbestos roll
DE19828722A1 (en) * 1998-06-29 1999-12-30 Schwaebische Huettenwerke Gmbh Calender roller structure for a calender to process tissue webs
CN101116802A (en) * 2007-09-04 2008-02-06 汕头市奇佳机械厂有限公司 Granulator
CN101878025A (en) * 2007-10-11 2010-11-03 菲利普莫里斯生产公司 Extrudable and extruded compositions for delivery of bioactive agents, method of making the same and method of using same
CN208693801U (en) * 2018-04-02 2019-04-05 济南亿民动物药业有限公司 A kind of Chinese medicine granulator
CN112500320A (en) * 2020-12-16 2021-03-16 江苏优扬药业有限公司 Preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate
US20220072493A1 (en) * 2019-01-24 2022-03-10 Novo Nordisk A/S Roller compactor and method of dry granulation using a roller compactor
CN217221361U (en) * 2022-04-27 2022-08-19 江苏优扬药业有限公司 Manufacturing device of sheet-shaped sulfoaliphatic new material

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Publication number Priority date Publication date Assignee Title
JPS55100415A (en) * 1979-01-26 1980-07-31 Nippon Valqua Ind Ltd Manufacturing method of asbestos roll
DE19828722A1 (en) * 1998-06-29 1999-12-30 Schwaebische Huettenwerke Gmbh Calender roller structure for a calender to process tissue webs
CN101116802A (en) * 2007-09-04 2008-02-06 汕头市奇佳机械厂有限公司 Granulator
CN101878025A (en) * 2007-10-11 2010-11-03 菲利普莫里斯生产公司 Extrudable and extruded compositions for delivery of bioactive agents, method of making the same and method of using same
CN208693801U (en) * 2018-04-02 2019-04-05 济南亿民动物药业有限公司 A kind of Chinese medicine granulator
US20220072493A1 (en) * 2019-01-24 2022-03-10 Novo Nordisk A/S Roller compactor and method of dry granulation using a roller compactor
CN112500320A (en) * 2020-12-16 2021-03-16 江苏优扬药业有限公司 Preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate
CN217221361U (en) * 2022-04-27 2022-08-19 江苏优扬药业有限公司 Manufacturing device of sheet-shaped sulfoaliphatic new material

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
邹小波: "中式中央厨房装备", 31 July 2021, 中国轻工业出版社, pages: 49 - 50 *

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