CN114699427B - Aluminum magnesium carbonate chewable tablet and preparation method thereof - Google Patents
Aluminum magnesium carbonate chewable tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an aluminum magnesium carbonate chewable tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: s1, pretreating auxiliary materials; s2, weighing raw materials; s3, preparing slurry; s4, mixing and granulating; s5, drying; s6, finishing; s7, total mixing; s8, tabletting; s9, packaging. The invention solves the problems of poor taste, low preparation efficiency and complicated procedures of the aluminum magnesium carbonate chewable tablet.
Description
Technical Field
The invention relates to the technical field of pharmaceutical preparations, in particular to an aluminum magnesium carbonate chewable tablet and a preparation method thereof.
Background
The aluminum magnesium carbonate chewable tablet is mainly used for treating chronic gastritis and stomach discomfort symptoms related to gastric acid, such as gastralgia, heartburn, acid eructation, fullness and the like.
At present, the aluminum magnesium carbonate chewable tablet generally has the problems of poor taste, low preparation efficiency, complicated procedures and the like, and in addition, the existing aluminum magnesium carbonate chewable tablet is mainly prepared by adopting a wet granulation mode, and the mode is simple to operate and low in preparation cost, so that the aluminum magnesium carbonate chewable tablet is widely used. The wet granules obtained after wet granulation are often subjected to drying treatment, and are usually dried by a split type boiling dryer at present, so that the boiling dryer not only increases the operation difficulty, but also is easy to cause air leakage and material leakage, and the working efficiency is lower.
In view of the above, the present invention provides an aluminum magnesium carbonate chewable tablet and a preparation method thereof.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an aluminum magnesium carbonate chewable tablet and a preparation method thereof, which solve the problems of poor taste, low preparation efficiency and complicated procedures of the aluminum magnesium carbonate chewable tablet.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the aluminum magnesium carbonate chewable tablet is prepared from aluminum magnesium carbonate and auxiliary materials, wherein the auxiliary materials comprise mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate;
wherein, every 500mg of aluminum magnesium carbonate, each component in the auxiliary materials is matched with the following dosage: 300-400mg of mannitol, 80-130mg of corn starch, 0.2-0.8mg of saccharin sodium, 30-50mg of carboxymethyl starch sodium, 500-600mg of purified water, 1-3mg of powder mint essence and 5-15mg of magnesium stearate.
Further preferred are: the aluminum magnesium carbonate has a particle size of less than 120 μm.
The preparation method of the aluminum magnesium carbonate chewable tablet comprises the following steps:
s1, pretreatment of auxiliary materials
Mannitol is processed by a swinging machine and then is sieved by a 60-mesh sieve, and saccharin sodium is processed by a pulverizer and then is sieved by an 80-mesh sieve for standby;
s2, weighing raw materials
Weighing aluminum magnesium carbonate, mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate according to the proportion of the raw materials in the aluminum magnesium carbonate chewable tablet;
s3, preparing slurry
Putting 1/4-1/3 of the weighed corn starch into a stainless steel barrel, adding two times of purified water of the corn starch, dispersing uniformly, transferring into a pulping pot, adding two times of purified water into the stainless steel barrel, washing, transferring into the pulping pot, repeating the operation twice, adding the rest of purified water, stirring uniformly, boiling, and keeping boiling for 3min; stirring and cooling to 60-70 ℃ to obtain starch slurry;
s4, mixing and granulating
Adding prepared aluminum magnesium carbonate, mannitol, residual corn starch, saccharin sodium and 1/2 sodium carboxymethyl starch into a wet granulator, and mixing for 5min at a stirring speed of 70 rpm; adding the starch slurry, granulating, sieving with square hole sieve, and discharging to obtain wet granules;
s5, drying
Drying the wet particles in the step S4 in an integrated boiling dryer to obtain dry particles with water content less than 4%;
s6, finishing
Granulating the dry granules in the step S5 by a granulating machine with a round hole sieve;
s7, total mixing
Mixing the powder mint essence, the rest carboxymethyl starch sodium and the dried granules after finishing the granules in a mixer for 10min, adding the weighed magnesium stearate, and continuing mixing for 3min at a rotating speed of 5 rpm;
s8, tabletting
Placing the total mixed materials into a tablet press for tablet pressing to obtain aluminum magnesium carbonate chewable tablets;
s9, packaging
And (5) packaging the aluminum magnesium carbonate chewable tablet in the step S8.
Further preferred are: in the step S5, the wet particles in the step S4 are placed in an integrated boiling dryer, and are dried until the temperature of the wet particles reaches 60 ℃ at the air inlet temperature of 80-85 ℃ and the fan frequency of 30-40 HZ; stopping heating, measuring the moisture content of the wet particles, and restarting the integrated boiling dryer to dry if the moisture content is not in accordance with the requirement until dry particles with the moisture content less than 4% are obtained.
Further preferred are: the integrated boiling dryer comprises a tank body, wherein the tank body sequentially comprises an air inlet chamber, a drying chamber and an air outlet chamber from bottom to top, a hot air inlet is formed in the side part of the air inlet chamber, an air outlet is formed in the side part of the air outlet chamber, and a feeding pipe and a discharging pipe for feeding and discharging materials are arranged in the side part of the drying chamber;
the novel drying device is characterized in that a screen is arranged between the air inlet chamber and the drying chamber, filter cloth is arranged between the drying chamber and the air outlet chamber, a driving mechanism, a stirring mechanism and a beating mechanism are arranged in the tank body, and the driving mechanism is used for driving the stirring mechanism to stir materials in the drying chamber and is used for driving the beating mechanism to beat the filter cloth.
Further preferred are: the driving mechanism comprises a motor and a main shaft;
the motor is located in the air inlet chamber and is installed at the bottom of the screen, the lower end of the main shaft is connected with the output shaft of the motor, and the upper end of the main shaft sequentially penetrates through the screen and the filter cloth and is inserted into the inner top of the air outlet chamber.
Further preferred are: the stirring mechanism comprises a supporting cross rod and a supporting vertical rod;
the support cross rod and the support vertical rod are both positioned in the drying chamber, one end of the support cross rod is fixed on the surface of the main shaft, the other end of the support cross rod extends towards the direction close to the side wall of the drying chamber, one end of the support vertical rod is fixed on the surface of the support cross rod, and the other end of the support vertical rod extends outwards in the radial direction of the support cross rod.
Further preferred are: the air outlet chamber is internally provided with a buffer mechanism, the buffer mechanism is connected between the filter cloth and the top of the air outlet chamber, and the beating mechanism is used for beating the filter cloth up and down so that materials adhered to the surface of the filter cloth enter the drying chamber.
Further preferred are: the beating mechanism comprises a worm, a worm wheel, a rotating shaft and a cam;
the worm, the worm wheel, the rotating shaft and the cam are all located in the air outlet chamber, the worm is arranged on the main shaft, the worm wheel is located on one side of the worm and is meshed with the worm, two ends of the rotating shaft are respectively inserted into two opposite sides in the air outlet chamber, the worm wheel and the cam are both fixed on the rotating shaft, and the circumferential surface of the cam is in contact with the top surface of the filter cloth.
Further preferred are: the filter cloth is arc-shaped and the outer cambered surface faces the air outlet chamber, the buffer mechanism comprises a support rod and a spring, the lower end of the support rod is fixed with the filter cloth, the upper end of the support rod is connected with the spring, the lower end of the spring is fixed with the support rod, and the upper end of the spring is fixed with the inner top of the air outlet chamber.
In summary, the invention has the following beneficial effects: the aluminum magnesium carbonate chewable tablet takes aluminum magnesium carbonate as a raw material, and mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate are added. In the invention, mannitol is used as an excipient, saccharin sodium is used as a sweetener, carboxymethyl starch sodium is used for thickening and bonding, and magnesium stearate is used as a glidant, so that the prepared aluminum magnesium carbonate chewable tablet has good and compact taste and is not easy to scatter. The integrated boiling dryer is adopted to replace the traditional split boiling dryer for wet particle drying, so that the integrated boiling dryer is simpler and more convenient to use, and the working efficiency is improved.
Drawings
FIG. 1 is a flow chart of an embodiment, which is mainly used for embodying the preparation method of the aluminum magnesium carbonate chewable tablet;
FIG. 2 is a schematic structural view of an embodiment, mainly used for embodying the structure of an integrated boiling dryer;
fig. 3 is a schematic cross-sectional view of an embodiment, primarily for embodying a cam mounting structure.
In the figure, 101, an air inlet chamber; 102. a drying chamber; 103. an air outlet chamber; 2. a hot air inlet; 3. an air outlet; 4. a feed pipe; 5. a discharge pipe; 61. a motor; 62. a main shaft; 71. a support rail; 72. a supporting vertical rod; 81. a worm; 82. a worm wheel; 83. a rotating shaft; 84. a cam; 91. a support rod; 92. a spring; 10. a filter cloth; 11. a cover body; 12. sealing cover; 13. and (3) screening.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and examples.
Example 1: the aluminum magnesium carbonate chewable tablet is prepared from aluminum magnesium carbonate and auxiliary materials, wherein the auxiliary materials comprise mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate. Wherein, every 500mg of aluminum magnesium carbonate, the auxiliary materials comprise the following components in proportion: mannitol 347.5mg, corn starch 104.57mg, saccharin sodium 0.5mg, carboxymethyl starch sodium 40mg, purified water 561.83mg, powdered peppermint essence 2mg and magnesium stearate 10mg. The aluminum magnesium carbonate particle size was 100 μm.
The preparation method of the aluminum magnesium carbonate chewable tablet, as shown in figure 1, comprises the following steps:
s1, pretreatment of auxiliary materials
Mannitol is processed by a swing type pulverizer and then is sieved by a 60-mesh sieve, and saccharin sodium is processed by the pulverizer and then is sieved by an 80-mesh sieve for standby.
S2, weighing raw materials
Weighing aluminum magnesium carbonate, mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate according to the proportion of the raw materials in the aluminum magnesium carbonate chewable tablet.
S3, preparing slurry
Putting 29.57mg of the weighed corn starch into a stainless steel barrel, adding purified water with the quantity twice that of the corn starch, dispersing uniformly, transferring into a pulp melting pot, adding purified water with the quantity twice that of the stainless steel barrel into the pulp melting pot for flushing, transferring into the pulp melting pot, repeating the operation twice, adding the rest purified water, stirring uniformly, boiling, and keeping boiling for 3min; stirring and cooling to 66 ℃ are kept, and 5% of starch slurry is obtained and used as an adhesive.
S4, mixing and granulating
Adding prepared aluminum magnesium carbonate, mannitol, residual corn starch, saccharin sodium and 20mg of carboxymethyl starch sodium into a wet granulator, and mixing for 5min at a stirring speed of 70 rpm; adding starch slurry, granulating, sieving with square sieve, and discharging to obtain wet granule;
preferably, the starch slurry is transferred into a pressure slurry adding tank above the top of the wet granulator, and the temperature of the starch slurry is measured and should be 55-70 ℃; by using
The spray head is used for adjusting the pressure of the slurry adding tank to be 0.35-0.38MPa, setting the stirring rotation speed of the wet granulator to be 70rpm, setting the shearing rotation speed to be 1500rpm, starting up and spraying 82.8+/-1.5 kg of 5% starch slurry, and stopping; opening a wet granulator cover, cleaning the wall of a pot, sweeping materials on the inner wall into the pot, and covering the cover; granulating at stirring speed of 70rpm and shearing speed of 1500rpm for 2-5min to obtain granule with proper size, dry and wet properties and hardness; and (3) adopting a square hole sieve with 8mm to carry out granulation and discharging to an integrated boiling dryer, wherein the granulation speed is 500rpm, and the stirring speed is 1-15rpm, so as to obtain wet granules.
S5, drying
Drying the wet particles in the step S4 in an integrated boiling dryer to obtain dry particles with water content less than 4%;
preferably, the wet particles in the step S4 are placed in an integrated boiling dryer, and are dried until the temperature of the wet particles reaches 60 ℃ at the air inlet temperature of 82 ℃ and the fan frequency of 35 HZ; stopping heating, measuring the moisture content of the wet particles, and restarting the integrated boiling dryer to dry if the moisture content is not in accordance with the requirement until dry particles with the moisture content less than 4% are obtained.
S6, finishing
And (3) granulating the dry granules in the step (S5) by a granulating machine with a phi 1.2mm round hole sieve, wherein the granulating rotating speed is 700+/-50 rpm.
S7, total mixing
Mixing powder herba Menthae essence, residual carboxymethyl starch sodium and dried granule in a mixer at 5rpm for 10min, adding weighed magnesium stearate, mixing at 5rpm for 3min, and discharging.
S8, tabletting
And (3) putting the total mixed materials into an S250smart tablet press to be pressed, and selecting an oblique flat punching die with the specification of phi 16mm to obtain the aluminum magnesium carbonate chewable tablet.
S9, packaging
And (5) packaging the aluminum magnesium carbonate chewable tablet in the step S8.
Preferably, the package specifications are: 10 sheets x 2 plates x 400 boxes/case.
Referring to fig. 2 to 3, the integrated boiling dryer includes a cylindrical tank body, and the inside of the tank body includes an air inlet chamber 101, a drying chamber 102 and an air outlet chamber 103 in this order from bottom to top. A hot air inlet 2 is arranged on one side of the lower part of the air inlet chamber 101, an air outlet 3 is arranged on one side of the lower part of the air outlet chamber 103, and a feeding pipe 4 and a discharging pipe 5 for material inlet and outlet are arranged on the side of the drying chamber 102. The inlet pipe 4 is located drying chamber 102 upper portion one side and one end is connected with drying chamber 102, and the other end upward sloping and an organic whole are connected with the feeder hopper, and the feeder hopper upper cover is equipped with lid 11. The discharging pipe 5 is arranged at one side of the lower part of the drying chamber 102, one end of the discharging pipe is connected with the drying chamber 102, the other end of the discharging pipe is inclined downwards and is connected with the sealing cover 12 in a threaded manner, and the feeding pipe 4 and the discharging pipe 5 are respectively arranged at two opposite sides of the drying chamber 102. A screen 13 is arranged between the air inlet chamber 101 and the drying chamber 102, a filter cloth 10 is arranged between the drying chamber 102 and the air outlet chamber 103, the filter cloth 10 is arranged in an arc shape, the outer arc surface faces the air outlet chamber 103, and the screen 13 and the filter cloth 10 are both fixed on the circumferential inner wall of the tank body.
Referring to fig. 2-3, a driving mechanism, a stirring mechanism and a beating mechanism are arranged in the tank body. The driving mechanism is used for driving the stirring mechanism to stir the materials in the drying chamber 102 and is used for driving the beating mechanism to beat the filter cloth 10. Preferably, the drive mechanism includes a motor 61 and a spindle 62. The motor 61 is located in the air inlet chamber 101 and is arranged at the center of the bottom of the screen 13, the main shaft 62 is vertically arranged, the lower end of the main shaft is connected with the output shaft of the motor 61, and the upper end of the main shaft sequentially passes through the screen 13 and the filter cloth 10 and is inserted into the top of the air outlet chamber 103. The stirring mechanism includes a support cross bar 71 and a support vertical bar 72. The support cross bar 71 and the support vertical bar 72 are both positioned in the drying chamber 102, one end of the support cross bar 71 is fixed on the surface of the main shaft 62, and the other end extends to a direction approaching to the side wall of the drying chamber 102. One end of the supporting vertical rod 72 is fixed on the surface of the supporting cross rod 71, the other end extends outwards in the radial direction of the supporting cross rod 71, and in order to play a better stirring role, a plurality of supporting vertical rods 72 are arranged at equal intervals along the axial direction of the supporting cross rod 71.
Referring to fig. 2 to 3, a buffer mechanism is provided in the air outlet chamber 103, and is connected between the filter cloth 10 and the top of the air outlet chamber 103, and a beating mechanism is used to beat the filter cloth 10 up and down so that the material adhered to the surface of the filter cloth 10 enters the drying chamber 102. Preferably, the flapping mechanism includes a worm 81, a worm gear 82, a spindle 83, and a cam 84. The worm 81, the worm wheel 82, the rotating shaft 83 and the cam 84 are all positioned in the air outlet chamber 103, the worm 81 is arranged on the main shaft 62, and the worm wheel 82 is positioned on one side of the worm 81 and is meshed with the worm 81. Both ends of the rotating shaft 83 are respectively inserted into two opposite sides of the inside of the air outlet chamber 103, the worm wheel 82 and the cam 84 are both fixed on the rotating shaft 83, and the circumferential surface of the cam 84 is contacted with the top surface of the filter cloth 10. The worm 81 is provided with a worm wheel 82, a rotating shaft 83, and a cam 84 on opposite sides in the radial direction. The two buffer mechanisms are symmetrically arranged on two opposite sides of the radial direction of the worm 81. The buffer mechanism comprises a supporting rod 91 and a spring 92, wherein the lower end of the supporting rod 91 is fixed with the filter cloth 10, the upper end of the supporting rod is connected with the spring 92, the lower end of the spring 92 is fixed with the supporting rod 91, and the upper end of the spring 92 is fixed with the inner top of the air outlet chamber 103.
In the technical scheme, the traditional boiling dryer adopts a split structure, namely, the material box used for drying can slide out of the tank body to carry out feeding and dumping, the design not only increases the operation difficulty and improves the workload of workers, but also has errors easily after the material box is pushed in, so that the material box has poor connection tightness and air leakage and material leakage easily occur. The material is fed in and out through the feeding pipe 4 and the discharging pipe 5, and during drying, the motor 61 is started, so that the main shaft 62 drives the supporting cross rod 71, the supporting vertical rod 72 and the worm 81 to rotate. The hot air enters the air inlet chamber 101 through a hot air outlet, enters the drying chamber 102 through the screen 13 for drying materials, finally enters the air outlet chamber 103 through the filter cloth 10, and finally is discharged through the air outlet 3. When the supporting cross rod 71 and the supporting vertical rod 72 rotate around the main shaft 62, the supporting cross rod 71 and the supporting vertical rod 72 can play a better stirring role, so that materials are fully contacted with hot air, drying efficiency and drying quality are improved, when the worm 81 rotates, the worm gear 82 drives the cam 84 and the rotating shaft 83 to rotate, and as the circumferential surface of the cam 84 is contacted with the top surface of the filter cloth 10, the filter cloth 10 shakes up and down under the action of the cam 84 and the spring 92 when the cam 84 rotates, and therefore, the materials adhered to the inner surface of the filter cloth 10 can be shaken off, material loss and filter cloth 10 blockage are reduced, and the use is simple and convenient.
Example 2: the aluminum magnesium carbonate chewable tablet and the preparation method thereof are different from example 1 in that each 500mg of aluminum magnesium carbonate is mixed with the following components in the auxiliary materials: 300mg of mannitol, 80mg of corn starch, 0.2mg of saccharin sodium, 30mg of carboxymethyl starch sodium, 500mg of purified water, 1mg of powder mint essence and 2mg of magnesium stearate. The aluminum magnesium carbonate particle size was 110. Mu.m.
The preparation method of the aluminum magnesium carbonate chewable tablet, as shown in figure 1, comprises the following steps:
s1, pretreatment of auxiliary materials
Mannitol is processed by a swing type pulverizer and then is sieved by a 60-mesh sieve, and saccharin sodium is processed by the pulverizer and then is sieved by an 80-mesh sieve for standby.
S2, weighing raw materials
Weighing aluminum magnesium carbonate, mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate according to the proportion of the raw materials in the aluminum magnesium carbonate chewable tablet.
S3, preparing slurry
Putting 26.4mg of weighed corn starch into a stainless steel barrel, adding purified water with the quantity twice that of the corn starch, dispersing uniformly, transferring into a slurry melting pot, adding purified water with the quantity twice that of the stainless steel barrel, washing, transferring into the slurry melting pot, repeating the operation twice, adding the rest purified water, stirring uniformly, boiling, and keeping boiling for 3min; stirring and cooling to 60 ℃ are kept, and 5% of starch slurry is obtained and used as an adhesive.
S4, mixing and granulating
Adding prepared aluminum magnesium carbonate, mannitol, residual corn starch, saccharin sodium and 15mg of carboxymethyl starch sodium into a wet granulator, and mixing for 5min at a stirring speed of 70 rpm; adding starch slurry, granulating, sieving with square sieve, and discharging to obtain wet granule.
S5, drying
Drying the wet particles in the step S4 in an integrated boiling dryer to obtain dry particles with water content less than 4%;
preferably, the wet particles in the step S4 are placed in an integrated boiling dryer, and are dried until the temperature of the wet particles reaches 60 ℃ at the air inlet temperature of 80 ℃ and the fan frequency of 30 HZ; stopping heating, measuring the moisture content of the wet particles, and restarting the integrated boiling dryer to dry if the moisture content is not in accordance with the requirement until dry particles with the moisture content less than 4% are obtained.
S6, finishing
And (3) granulating the dry granules in the step (S5) by a granulating machine with a phi 1.2mm round hole sieve, wherein the granulating rotating speed is 700+/-50 rpm.
S7, total mixing
Mixing powder herba Menthae essence, residual carboxymethyl starch sodium and dried granule in a mixer at 5rpm for 10min, adding weighed magnesium stearate, mixing at 5rpm for 3min, and discharging.
S8, tabletting
And (3) putting the total mixed materials into an S250smart tablet press to be pressed, and selecting an oblique flat punching die with the specification of phi 16mm to obtain the aluminum magnesium carbonate chewable tablet.
S9, packaging
And (5) packaging the aluminum magnesium carbonate chewable tablet in the step S8.
Example 3: the aluminum magnesium carbonate chewable tablet and the preparation method thereof are different from example 1 in that each 500mg of aluminum magnesium carbonate is mixed with the following components in the auxiliary materials: 400mg of mannitol, 130mg of corn starch, 0.8mg of saccharin sodium, 50mg of carboxymethyl starch sodium, 600mg of purified water, 3mg of powdery peppermint essence and 15mg of magnesium stearate. The aluminum magnesium carbonate particle size was 110. Mu.m.
The preparation method of the aluminum magnesium carbonate chewable tablet, as shown in figure 1, comprises the following steps:
s1, pretreatment of auxiliary materials
Mannitol is processed by a swing type pulverizer and then is sieved by a 60-mesh sieve, and saccharin sodium is processed by the pulverizer and then is sieved by an 80-mesh sieve for standby.
S2, weighing raw materials
Weighing aluminum magnesium carbonate, mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate according to the proportion of the raw materials in the aluminum magnesium carbonate chewable tablet.
S3, preparing slurry
Placing 32.5mg of the weighed corn starch into a stainless steel barrel, adding purified water with the quantity of two times of that of the corn starch, dispersing uniformly, transferring into a slurry melting pot, adding purified water with the quantity of two times of that of the stainless steel barrel into the stainless steel barrel, washing, transferring into the slurry melting pot, repeating the operation twice, adding the rest purified water, stirring uniformly, boiling, and keeping boiling for 3min; stirring and cooling to 70 ℃ are kept, and 5% of starch slurry is obtained and used as an adhesive.
S4, mixing and granulating
Adding prepared aluminum magnesium carbonate, mannitol, residual corn starch, saccharin sodium and 25mg of carboxymethyl starch sodium into a wet granulator, and mixing for 5min at a stirring speed of 70 rpm; adding starch slurry, granulating, sieving with square sieve, and discharging to obtain wet granule.
S5, drying
Drying the wet particles in the step S4 in an integrated boiling dryer to obtain dry particles with water content less than 4%;
preferably, the wet particles in the step S4 are placed in an integrated boiling dryer, and are dried until the temperature of the wet particles reaches 60 ℃ at the air inlet temperature of 85 ℃ and the fan frequency of 40 HZ; stopping heating, measuring the moisture content of the wet particles, and restarting the integrated boiling dryer to dry if the moisture content is not in accordance with the requirement until dry particles with the moisture content less than 4% are obtained.
S6, finishing
And (3) granulating the dry granules in the step (S5) by a granulating machine with a phi 1.2mm round hole sieve, wherein the granulating rotating speed is 700+/-50 rpm.
S7, total mixing
Mixing powder herba Menthae essence, residual carboxymethyl starch sodium and dried granule in a mixer at 5rpm for 10min, adding weighed magnesium stearate, mixing at 5rpm for 3min, and discharging.
S8, tabletting
And (3) putting the total mixed materials into an S250smart tablet press to be pressed, and selecting an oblique flat punching die with the specification of phi 16mm to obtain the aluminum magnesium carbonate chewable tablet.
S9, packaging
And (5) packaging the aluminum magnesium carbonate chewable tablet in the step S8.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that numerous improvements and modifications can be made by those skilled in the art without departing from the principles of the present invention, and such improvements and modifications are also considered to be within the scope of the present invention.
Claims (4)
1. A preparation method of an aluminum magnesium carbonate chewable tablet is characterized by comprising the following steps: the method comprises the following steps:
s1, pretreatment of auxiliary materials
Mannitol is processed by a swinging machine and then is sieved by a 60-mesh sieve, and saccharin sodium is processed by a pulverizer and then is sieved by an 80-mesh sieve for standby;
s2, weighing raw materials
Weighing aluminum magnesium carbonate, mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate;
s3, preparing slurry
Putting 1/4-1/3 of the weighed corn starch into a stainless steel barrel, adding two times of purified water of the corn starch, dispersing uniformly, transferring into a pulping pot, adding two times of purified water into the stainless steel barrel, washing, transferring into the pulping pot, repeating the operation twice, adding the rest of purified water, stirring uniformly, boiling, and keeping boiling for 3min; stirring and cooling to 60-70 ℃ to obtain starch slurry;
s4, mixing and granulating
Adding prepared aluminum magnesium carbonate, mannitol, residual corn starch, saccharin sodium and 1/2 sodium carboxymethyl starch into a wet granulator, and mixing for 5min at a stirring speed of 70 rpm; adding the starch slurry, granulating, sieving with square hole sieve, and discharging to obtain wet granules;
s5, drying
Drying the wet particles in the step S4 in an integrated boiling dryer to obtain dry particles with water content less than 4%;
s6, finishing
Granulating the dry granules in the step S5 by a granulating machine with a round hole sieve;
s7, total mixing
Mixing the powder mint essence, the rest carboxymethyl starch sodium and the dried granules after finishing the granules in a mixer for 10min, adding the weighed magnesium stearate, and continuing mixing for 3min at a rotating speed of 5 rpm;
s8, tabletting
Placing the total mixed materials into a tablet press for tablet pressing to obtain aluminum magnesium carbonate chewable tablets;
s9, packaging
Packaging the aluminum magnesium carbonate chewable tablets in the step S8 to obtain the aluminum magnesium carbonate chewable tablets;
the integrated boiling dryer comprises a tank body, wherein the tank body sequentially comprises an air inlet chamber (101), a drying chamber (102) and an air outlet chamber (103) from bottom to top, a hot air inlet (2) is arranged at the side part of the air inlet chamber (101), an air outlet (3) is arranged at the side part of the air outlet chamber (103), and a feeding pipe (4) and a discharging pipe (5) for feeding and discharging materials are arranged at the side part of the drying chamber (102);
a screen (13) is arranged between the air inlet chamber (101) and the drying chamber (102), a filter cloth (10) is arranged between the drying chamber (102) and the air outlet chamber (103), a driving mechanism, a stirring mechanism and a beating mechanism are arranged in the tank body, and the driving mechanism is used for driving the stirring mechanism to stir materials in the drying chamber (102) and is used for driving the beating mechanism to beat the filter cloth (10);
the driving mechanism comprises a motor (61) and a main shaft (62);
the motor (61) is positioned in the air inlet chamber (101) and is arranged at the bottom of the screen (13), the lower end of the main shaft (62) is connected with the output shaft of the motor (61), and the upper end of the main shaft sequentially passes through the screen (13) and the filter cloth (10) and is inserted into the inner top of the air outlet chamber (103);
the stirring mechanism comprises a supporting cross rod (71) and a supporting vertical rod (72);
the support cross rod (71) and the support vertical rod (72) are both positioned in the drying chamber (102), one end of the support cross rod (71) is fixed on the surface of the main shaft (62), the other end of the support cross rod extends towards the direction close to the side wall of the drying chamber (102), one end of the support vertical rod (72) is fixed on the surface of the support cross rod (71), and the other end of the support vertical rod extends outwards towards the radial direction of the support cross rod (71);
the flapping mechanism comprises a worm (81), a worm wheel (82), a rotating shaft (83) and a cam (84);
the worm (81), the worm wheel (82), the rotating shaft (83) and the cam (84) are all positioned in the air outlet chamber (103), the worm (81) is arranged on the main shaft (62), the worm wheel (82) is positioned on one side of the worm (81) and is meshed with the worm (81), two ends of the rotating shaft (83) are respectively inserted into two opposite sides in the air outlet chamber (103), the worm wheel (82) and the cam (84) are both fixed on the rotating shaft (83), and the circumferential surface of the cam (84) is in contact with the top surface of the filter cloth (10);
a buffer mechanism is arranged in the air outlet chamber (103), the buffer mechanism is connected between the filter cloth (10) and the top of the air outlet chamber (103), and the beating mechanism is used for beating the filter cloth (10) up and down so that materials adhered to the surface of the filter cloth (10) enter the drying chamber (102);
the filter cloth (10) is arc-shaped, the outer arc surface faces the air outlet chamber (103), the buffer mechanism comprises a support rod (91) and a spring (92), the lower end of the support rod (91) is fixed with the filter cloth (10), the upper end of the support rod is connected with the spring (92), the lower end of the spring (92) is fixed with the support rod (91), and the upper end of the spring is fixed with the inner top of the air outlet chamber (103).
2. The method for preparing the aluminum magnesium carbonate chewable tablet according to claim 1, wherein the method comprises the following steps: the aluminum magnesium carbonate chewable tablet is prepared from aluminum magnesium carbonate and auxiliary materials, wherein the auxiliary materials comprise mannitol, corn starch, saccharin sodium, carboxymethyl starch sodium, purified water, powder mint essence and magnesium stearate;
wherein, every 500mg of aluminum magnesium carbonate, each component in the auxiliary materials is matched with the following dosage:
300-400mg of mannitol, 80-130mg of corn starch, 0.2-0.8mg of saccharin sodium, 30-50mg of carboxymethyl starch sodium, 500-600mg of purified water, 1-3mg of powder mint essence and 5-15mg of magnesium stearate.
3. The method for preparing the aluminum magnesium carbonate chewable tablet according to claim 2, wherein the method comprises the following steps: the aluminum magnesium carbonate has a particle size of less than 120 μm.
4. A method for preparing an aluminum magnesium carbonate chewable tablet according to any one of claims 1 to 3, wherein: in the step S5, the wet particles in the step S4 are placed in an integrated boiling dryer, and are dried until the temperature of the wet particles reaches 60 ℃ at the air inlet temperature of 80-85 ℃ and the fan frequency of 30-40 HZ; stopping heating, measuring the moisture content of the wet particles, and restarting the integrated boiling dryer to dry if the moisture content is not in accordance with the requirement until dry particles with the moisture content less than 4% are obtained.
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| CN2653401Y (en) * | 2003-07-10 | 2004-11-03 | 田洪春 | Fluidized drying pelleting machine/driver having automatic powder cleaning and washing function |
| CN101219150A (en) * | 2007-12-19 | 2008-07-16 | 游洪涛 | Rapidly effectual aluminum magnesium carbonate preparation and technique of preparing the same |
| CN101846438B (en) * | 2010-05-05 | 2011-05-04 | 贾平 | Circulating fluidized bed boiling dryer and drying method of powder material |
| CN203672053U (en) * | 2013-12-26 | 2014-06-25 | 南通康鑫药业有限公司 | Boiling drying system |
| CN204301413U (en) * | 2014-11-30 | 2015-04-29 | 江西麒麟化工有限公司 | Boiling drier |
| CN206875826U (en) * | 2017-04-28 | 2018-01-12 | 江苏健达干燥工程有限公司 | A kind of boiling drier |
| CN110131965B (en) * | 2019-05-10 | 2020-04-07 | 特一药业集团股份有限公司 | Granulating equipment for preparing hydrotalcite chewable tablets and hydrotalcite chewable tablet production process |
| CN211233624U (en) * | 2019-12-12 | 2020-08-11 | 长春人民药业集团有限公司 | Fluidized drying bed with fine powder recovery function |
| CN112494336A (en) * | 2020-12-14 | 2021-03-16 | 重庆华森制药股份有限公司 | Intelligent manufacturing method and system of hydrotalcite chewable tablet |
| CN112675192A (en) * | 2021-01-12 | 2021-04-20 | 遂成药业股份有限公司 | Hydrotalcite chewable tablet and preparation method thereof |
| CN215571606U (en) * | 2021-02-09 | 2022-01-18 | 滁州格锐矿业有限责任公司 | Powder dryer |
| CN114177154A (en) * | 2022-01-04 | 2022-03-15 | 四川健能制药有限公司 | Chewable tablet containing aluminum magnesium carbonate and preparation method thereof |
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