CN112494336A - Intelligent manufacturing method and system of hydrotalcite chewable tablet - Google Patents
Intelligent manufacturing method and system of hydrotalcite chewable tablet Download PDFInfo
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 55
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 37
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 title claims abstract description 37
- 229960001545 hydrotalcite Drugs 0.000 title claims abstract description 37
- 229910001701 hydrotalcite Inorganic materials 0.000 title claims abstract description 37
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 138
- 238000003756 stirring Methods 0.000 claims abstract description 103
- 238000002156 mixing Methods 0.000 claims abstract description 63
- 238000001035 drying Methods 0.000 claims abstract description 54
- 238000005303 weighing Methods 0.000 claims abstract description 54
- 229920002472 Starch Polymers 0.000 claims abstract description 42
- 235000019698 starch Nutrition 0.000 claims abstract description 42
- 239000008107 starch Substances 0.000 claims abstract description 42
- 239000002002 slurry Substances 0.000 claims abstract description 32
- 238000004806 packaging method and process Methods 0.000 claims abstract description 29
- 239000008187 granular material Substances 0.000 claims abstract description 17
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 11
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000011777 magnesium Substances 0.000 claims abstract description 10
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 10
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 8
- 238000009835 boiling Methods 0.000 claims abstract description 3
- 238000003860 storage Methods 0.000 claims description 22
- 239000000686 essence Substances 0.000 claims description 19
- 238000005469 granulation Methods 0.000 claims description 16
- 230000003179 granulation Effects 0.000 claims description 16
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 14
- 229930195725 Mannitol Natural products 0.000 claims description 14
- 239000000594 mannitol Substances 0.000 claims description 14
- 235000010355 mannitol Nutrition 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 9
- 238000005550 wet granulation Methods 0.000 claims description 9
- 239000003826 tablet Substances 0.000 claims description 8
- 230000007306 turnover Effects 0.000 claims description 8
- 238000012546 transfer Methods 0.000 claims description 7
- 238000005520 cutting process Methods 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 4
- UJOHNXQDVUADCG-UHFFFAOYSA-L aluminum;magnesium;carbonate Chemical compound [Mg+2].[Al+3].[O-]C([O-])=O UJOHNXQDVUADCG-UHFFFAOYSA-L 0.000 claims description 3
- 238000013474 audit trail Methods 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 3
- 238000009826 distribution Methods 0.000 claims description 3
- 230000026676 system process Effects 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 description 13
- 230000005540 biological transmission Effects 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 239000013067 intermediate product Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- 241000234295 Musa Species 0.000 description 2
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 150000004645 aluminates Chemical class 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract
The invention provides an intelligent manufacturing method and system of a hydrotalcite chewable tablet, wherein the method comprises the following steps: s1: creating a material work order and a workflow; s2: weighing and feeding, namely automatically conveying the materials into a wet granulating machine in sequence according to the weight according to a pre-established material work order, and stirring and mixing according to a first stirring parameter set by a workflow; s3: granulating by a cutter, namely starting a low-speed cutter according to the workflow, adding pre-prepared starch slurry, and then starting a low-speed stirring cutter and a high-speed cutter according to the time designed by the workflow for granulating; s4: and (5) drying and packaging, namely transferring the granules obtained in the step S3 into a boiling dryer, drying according to a working flow, transferring into a total mixing machine, adding magnesium stearate, mixing, and finally tabletting and packaging to obtain the magnesium aluminocarbonate chewable tablets. The method respectively controls the material feeding time, the time of each stage, the environmental parameters and the like through the material work order and the work flow, and achieves the effect of accurately, intelligently and massively manufacturing the hydrotalcite chewable tablets.
Description
Technical Field
The invention belongs to the technical field of intelligent production, and particularly relates to an intelligent manufacturing method and system of an aluminum magnesium carbonate chewable tablet.
Background
The hydrotalcite is an antacid, is commonly used for treating gastropathy, and is mainly dependent on artificial production in the conventional production line for producing the hydrotalcite chewable tablets, namely the putting time, the operating environment and the like of materials are manually controlled, so that the cost is high, and the pollution to the materials, medicines and the like in the production process is easily caused; on the other hand, the hydrotalcite chewable tablet has a lot of materials in the production, the putting sequence, the putting time and the putting place are different, and if manual work is adopted, the time is wasted; moreover, the quality supervision of the medicine is strict, the data and quality in production cannot be monitored in real time in manual production, and when production errors occur, production error points are difficult to find back.
Therefore, some manufacturers propose to use intelligent equipment, and in the production process, the production time and the labor cost are reduced through the manufacture of the intelligent equipment.
Disclosure of Invention
In view of the above, an object of the present invention is to provide an intelligent manufacturing method of hydrotalcite chewable tablet, which can efficiently and rapidly manufacture hydrotalcite chewable tablet.
In order to achieve the purpose, the technical scheme of the invention is as follows: an intelligent manufacturing method of a hydrotalcite chewable tablet comprises the following steps:
s1: creating a material work order and a workflow, the material work order comprising: the material type, the material quantity and the material putting time, wherein the working flow comprises parameter setting in the manufacturing process; the material types include: hydrotalcite, mannitol, starch and essence; wherein,
the aluminum magnesium carbonate, the mannitol, the starch and the essence are as follows by weight: 253 parts of 215 and 223 parts of 227 parts of 36-48 parts of 1-1.2 parts of sodium chloride;
s2: weighing and feeding, namely automatically conveying the materials into a wet granulation machine in sequence according to the weight according to a pre-established material work order, and stirring and mixing according to a first stirring parameter set by the workflow;
s3: granulating by a cutter, namely starting a low-speed cutter according to the working flow, adding 5.4-7.2 parts of starch slurry with the concentration of 5-10% prepared in advance, and then starting low-speed stirring and a high-speed cutter according to the time designed by the working flow to granulate;
s4: and (5) drying and packaging, namely transferring the granules obtained in the step S3 into a boiling dryer, drying according to a working flow, transferring into a total mixing machine, adding magnesium stearate, mixing, and finally tabletting and packaging to obtain the magnesium aluminocarbonate chewable tablets.
Further, the step S2 specifically includes:
according to the material types on the material work order, materials stored in different places reach a weighing center according to distribution paths set by a workflow; the weighing centers comprise a plurality of weighing centers, and one material corresponds to one weighing center independently;
the weighing center is used for weighing the materials according to the weight of the materials on the material work order, and then the materials corresponding to the weight of the materials are conveyed into the wet granulation machine according to the material feeding time sequence by the centralized path set by the workflow;
and stirring and mixing according to a first stirring parameter set by the workflow.
Further, the first stirring parameter includes: the stirring device comprises a first stirring time and a first stirring speed, wherein the first stirring time is 25-35 s, and the first stirring speed is 1.3-1.6 m/s.
Further, the step S3 specifically includes the following steps:
starting a low-speed cutter in the wet granulating machine which is processed by the step S2 according to the low-speed cutter parameter set by the working flow;
adding 5.4-7.2 parts of starch slurry with the concentration of 5-10%, and then starting low-speed stirring and high-speed cutting according to the high-speed cutting parameter and the second stirring parameter set by the workflow; the low-speed cutter parameters comprise low-speed cutter speed and low-speed cutter time; the high-speed cutter parameters comprise high-speed cutter speed and high-speed cutter time, and the second stirring parameters comprise second stirring time and second stirring speed.
Further, the speed of the low-speed cutter is 1500-2000 rpm, and the time of the low-speed cutter is 40-60 s;
the high-speed cutter speed is 1500-2000 rpm, and the high-speed cutter time is 120-180 s;
the second stirring time is 180s and the second stirring speed is 100-140 rpm;
further, the step S4 specifically includes the following steps:
after step S3, the wet granulator automatically opens the discharge port, and the granules obtained in step S3 reach the turnover bucket according to the route set by the workflow;
meanwhile, the dryer is adjusted to a drying environment according to drying parameters set by the workflow, and then the particles in the turnover barrel are sucked into the dryer for drying;
feeding the dried granules into a total mixer through a route set by a workflow, adding 1-2 parts by weight of magnesium stearate, and mixing according to mixing parameters set by the workflow; the mixing parameters comprise mixing rotating speed and mixing time;
and (3) transferring the mixed particles into a tablet machine along a route set by a workflow for tabletting, and then transferring into an aluminum-plastic-aluminum machine for packaging to obtain the hydrotalcite chewable tablets.
In view of the above, the second objective of the present invention is to provide an intelligent manufacturing system for hydrotalcite chewable tablet, which can be used for the production and manufacturing of hydrotalcite chewable tablet.
In order to achieve the purpose, the technical scheme of the invention is as follows: an intelligent manufacturing system of a magnesium aluminocarbonate chewable tablet, comprising:
the main control module is used for creating a material work order and a workflow and controlling the flow of the system through the material work order and the workflow; the material work order comprises: the material type, the material component and the material putting time, wherein the working flow comprises parameter setting in the manufacturing process; the material types include: hydrotalcite, mannitol, starch and essence;
the storage module is in communication connection with the main control module and is used for separately storing different materials;
the weighing module is connected with the storage module through a conveying device, is connected with the main control module and is used for receiving and weighing materials according to the weight of the materials;
the granulation module is connected with the weighing module through a conveying device, connected with the main control module, used for receiving materials according to the material putting time, and used for stirring, mixing and granulating by a cutter according to parameters set by the workflow;
and the drying and packaging module is connected with the granulating module through a conveying device, connected with the weighing module through a conveying device, connected with the main control module, and used for receiving the granules obtained by the granulating module and drying, mixing, tabletting and packaging according to the parameters set by the workflow.
Furthermore, the weighing module comprises a plurality of weighing devices, and one weighing device is connected with the stored materials in one storage module one by one through the transfer device.
Further, the parameters set by the workflow include a first stirring parameter for controlling the granulation module to stir, a cutter parameter for controlling the granulation module to cut a cutter, a drying parameter for controlling the drying and packaging module to dry, and a mixing parameter for controlling the drying and packaging module to mix;
the first stirring parameters include: a first stirring time and a first stirring speed;
the cutter parameters include: cutter speed, cutter time;
the drying parameters include: drying time and drying environment temperature;
the mixing parameters include: mixing speed and mixing time.
And the audit trail module, the storage module, the weighing module and the drying and packaging module are used for monitoring data in the receiving system in real time and controlling the quality of a product in the system process.
Further, the first stirring time is 25-35 s, and the first stirring speed is 1.3-1.6 m/s.
The invention has the beneficial effects that: the invention provides an intelligent manufacturing method and system of a hydrotalcite chewable tablet, wherein the method comprises the steps of controlling the feeding amount and time of materials in the hydrotalcite chewable tablet manufacturing process through a material work order; meanwhile, the work flow controls the conveying paths of time, environmental parameters, materials, intermediate products and the like of each stage in the manufacturing process of the hydrotalcite chewable tablet, and the effect of manufacturing the hydrotalcite chewable tablet accurately, efficiently, intelligently and in large batch is achieved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is obvious that the drawings in the following description are some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive exercise.
FIG. 1 is a schematic diagram of a system for intelligently manufacturing hydrotalcite chewable tablets according to the present invention;
fig. 2 is a flow chart of an intelligent manufacturing method of the hydrotalcite chewable tablet.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The examples are given for the purpose of better illustration of the invention, but the invention is not limited to the examples. Therefore, those skilled in the art should make insubstantial modifications and adaptations to the embodiments of the present invention in light of the above teachings and remain within the scope of the invention.
Example 1
Referring to fig. 1, a schematic structural diagram of an intelligent manufacturing system of a magnesium aluminocarbonate chewable tablet according to the present invention, specifically, an intelligent manufacturing system of a magnesium aluminocarbonate chewable tablet, includes:
the main control module 1 is used for creating a material work order and a workflow and controlling the flow parameters of the system through the material work order and the workflow; the material work order includes: the material type, the material component and the material putting time, and the working flow comprises time setting and parameter setting in the manufacturing process; the material types include: hydrotalcite, mannitol, starch and essence; in the system, a material work order and a workflow can be created through loading the MES system;
the storage module 2 is in communication connection with the main control module and is used for separately storing different materials;
in this embodiment, the storage module 2 includes a plurality of automated warehouses, each warehouse stores one type of material, and the material storage medium may be a minimum package, an outer package tray for containing materials, and the like;
preferably, for different materials, the warehouse environments for storing the materials are different, such as refrigeration, drying and the like, the system performs inventory coding on the materials of different types in each reference for distinguishing, and the main control module 1 can also detect whether the environment of the storage warehouse meets the storage standard according to the codes of the materials;
the weighing module 3 is connected with the storage module 2 through a conveying device, is connected with the main control module and is used for receiving and weighing materials according to the weight of the materials;
in this embodiment, the weighing module 3 includes a plurality of weighing devices, and one weighing device is connected with the warehouse for storing materials in one storage module one by one through a transfer device, the transfer device can be a conveyor belt, or a track is arranged in the warehouse and the weighing device, and the trolley transports the materials through the track;
preferably, the material work order controls the opening and closing time of the storage module 2, and the materials are conveyed to the weighing module according to different stage time of the production flow, for example, only the hydrotalcite, the mannitol, the starch and the essence are conveyed to the weighing module 3 in the granulation stage, and the materials are weighed according to the material parts set in the material work order;
the weighing module 3 in this embodiment may weigh according to the material storage media of each warehouse in the storage module 2, if 12kg of starch is needed in one production, the starch is stored in small packages, and the unit of one package is 5kg, then, in the process of conveying 12kg of starch, the main control module transports 2 complete packages of starch by scanning the codes on the starch packages, and then weighs 2kg of starch in bulk by the weighing device, so as to achieve weighing of the set material amount in the material work order;
of course, in other embodiments, if the conveyed material is larger than the required material amount, a return device corresponding to the conveying device is further arranged between the weighing device and each warehouse, and the redundant material is sent back to the corresponding warehouse;
the granulating module 4 is connected with the weighing module 3 through a conveying device, is connected with the main control module 1, is used for receiving materials according to the material putting time, and is used for stirring, mixing and granulating by a cutter according to parameters set by a workflow;
in a specific embodiment, the materials required in the granulation module set in the workflow are hydrotalcite, mannitol, starch and essence, and the material recipe sets the hydrotalcite, mannitol, starch and essence according to the weight ratio: 1-2 parts of 2-4 parts of 4-5 parts of 5-6 parts of;
the granulation module 4 comprises a wet granulation machine, the wet granulation machine is connected with the weighing module through a conveying device, it is noted that the conveying device is not the same as the conveying device between the weighing module and the storage module, materials with the same weight are weighed in the weighing module 3 according to the weight of the magnesium aluminate carbonate, the mannitol, the starch and the essence set in the material work order and are conveyed into the wet granulation machine through the conveying device, and then stirring and mixing are carried out according to a first stirring parameter set by a workflow, wherein the first stirring parameter comprises: the stirring device comprises a first stirring time and a first stirring speed, wherein the first stirring time is 25-35 s, and the first stirring speed is 1.3-1.6 m/s;
after the stirring time set by the workflow is finished, automatically closing stirring, starting a low-speed cutter in the wet granulation machine according to a low-speed cutter parameter set by the workflow, meanwhile, setting 5.4-7.2 parts of starch slurry with the concentration of 5-10% in the material feeding time in the material work order, and then starting the low-speed stirring and high-speed cutter according to a high-speed cutter parameter set by the workflow and a second stirring parameter; the low-speed cutter parameters comprise low-speed cutter speed and low-speed cutter time; the high-speed cutter parameters comprise high-speed cutter speed and high-speed cutter time, and the second stirring parameters comprise second stirring time and second stirring speed.
The speed of the low-speed cutter is 1500-2000 rpm, and the time of the low-speed cutter is 40-60 s;
the high-speed cutter speed is 1500-2000 rpm, and the high-speed cutter time is 120-180 s;
the second stirring time is 180s and the second stirring speed is 100-140 rpm;
in this embodiment, starch slurry with a concentration of 5-10% is simultaneously manufactured when the materials are granulated in the granulating module 4, specifically, the system further comprises a slurry preparation module, which is connected with the output end of the weighing module and connected with the main control module, and comprises a slurry preparation barrel, normal-temperature purified water is weighed in the slurry preparation barrel according to the material amount required by slurry preparation on the material work order in the main control module, starch is weighed by the weighing module through the storage module and reaches the slurry preparation barrel, then the starch is stirred according to the slurry preparation stirring parameters set by the workflow, finally, the steam valve is opened to heat the slurry preparation barrel until the starch is completely dissolved, and the main control module controls the closing of the steam valve, so that the starch slurry with a corresponding concentration is obtained.
And the drying and packaging module 5 is connected with the granulating module 4 through a conveying device, connected with the weighing module through a conveying device, and connected with the main control module, and is used for receiving the granules obtained by the granulating module, and drying, mixing, tabletting and packaging are carried out according to parameters set by the workflow.
In this embodiment, the drying and packaging module 5 includes a transfer drum, a dryer, a main mixer, and a tablet press, and the connection relationship between the transfer drum and the wet granulator is that the input end of the transfer drum is connected to the output end of the wet granulator through a transmission device, the output end of the wet granulator is connected to the input end of the dryer through a transmission device, the main mixer and the dryer are connected to each other through a transmission device, and the output end of the main mixer and the tablet press are connected to each other through a transmission device; the conveying equipment in the dry packaging module 5 may be a cylindrical tube for transport;
in this embodiment, the intermediate product obtained by the granulation module 4 reaches the turnover drum through the transmission device, the dryer is adjusted to a drying environment according to the drying parameters set by the workflow, and then the particles in the turnover drum are sucked into the dryer for drying;
feeding the dried granules into a total mixer through a route set by a workflow, adding 1-2 parts by weight of magnesium stearate, and mixing according to mixing parameters set by the workflow; the mixing parameters comprise mixing rotating speed and mixing time;
and (3) transferring the mixed particles into a tablet machine along a route set by a workflow for tabletting, and then transferring into an aluminum-plastic-aluminum machine for packaging to obtain the hydrotalcite chewable tablets.
The parameters set by the workflow comprise a stirring parameter for controlling the granulation module to stir, a cutter parameter for controlling the granulation module to cut a cutter, a drying parameter for controlling the drying and packaging module to dry, a mixing parameter for controlling the drying and packaging module to mix and a slurry mixing and stirring parameter;
the first stirring parameter of stirring parameter stirring mixture and the second stirring parameter when the cutter pelletizes, first stirring parameter includes: a first stirring time and a first stirring speed; the second stirring parameters include: a second stirring time and a second stirring speed;
the slurry mixing and stirring parameters comprise: mixing time and speed of slurry;
the parameters of the low-speed cutter after stirring and mixing the parameters of the cutter and the parameters of the high-speed cutter after adding the starch slurry, wherein the parameters of the low-speed cutter comprise: low speed cutter speed, low speed cutter time; the high-speed cutter parameters include: high speed cutter speed, high speed cutter time;
the drying parameters include: drying time and drying environment temperature; if the drying environment temperature is 100-150 ℃, the drying time is 25-30 minutes;
the mixing parameters include: mixing speed and mixing time; if the mixing speed is 8-10rpm, the mixing time is 100-140 minutes.
Further comprises an audit trail module 6 which is connected with the storage module 2, the weighing module 3, the granulating module 4 and the drying and packaging module 5, used for monitoring data in a receiving system in real time and monitoring the quality of products in the system process, such as the quality guarantee period and the quality of materials in a warehouse, or whether the quality of the raw materials weighed in the weighing module 3 meets the production level and whether the precision of the weighing equipment is standard or not, or whether the granulation environment set by the workflow parameters in the granulation module 4 meets the granulation standard, the frequently-used forming state, the weight and the like obtained in the operation process of the granulation module 4 are detected, whether the starch slurry in the slurry preparation module meets the production standard, and whether the weight of the dry granules in the dry granulation module and the weight of the finally obtained hydrotalcite chewable tablet are in the specified production range are detected; (for example, in one embodiment, the loss on drying of the particles is preferably 2 to 5%).
Preferably, the system of the invention further comprises a post module, and the post module can clean and reset each module of the system after the system is used; before use, the modules meet the production requirements, such as sterile environment and the like.
Example 2
Based on the intelligent manufacturing system of the magnesium aluminocarbonate chewable tablet in example 1, this example provides an intelligent manufacturing method of the magnesium aluminocarbonate chewable tablet, which includes the following steps:
s1: creating a material work order and a workflow; then, step S2 is executed;
in this step, establish material work order and workflow through host system, the material work order includes: the material type, the material quantity and the material putting time, and the working flow comprises parameter setting in the manufacturing process; the material types include: hydrotalcite, mannitol, starch and essence; wherein, the hydrotalcite, the mannitol, the starch and the essence are as follows according to the weight portion: 253 parts of 215-223-227 parts of 36-48 parts of 1-1.2 parts of essence, and the essence comprises: the mint essence and the banana essence comprise the following components in parts by weight: 2.5-3.5 parts: 1-1.5 parts;
s2: weighing and feeding, namely automatically conveying the materials into a wet granulating machine in sequence according to the weight according to a pre-established material work order, and stirring and mixing according to a first stirring parameter set by a workflow; then, step S3 is executed;
according to the type of the materials on the material work order, the materials stored in different places (warehouses) reach a weighing module according to a distribution path set by a workflow; the weighing center comprises a plurality of weighing devices, one material warehouse corresponds to one weighing device independently, and the previous routes of the weighing devices are not crossed and overlapped;
the weighing center is used for weighing the materials according to the weight of the materials on the material work order, and then the materials corresponding to the weight of the materials are conveyed into the wet granulation machine according to the material feeding time sequence by a centralized path set by a workflow; for example, in a specific embodiment, 110 ten thousand almagnesium carbonate chewable tablets (the weight of the almagnesium carbonate chewable tablets is 0.5 g/tablet) are required to be prepared, the weight of the almagnesium carbonate is set to be 550kg, the weight of mannitol is 495kg, the weight of starch is 90kg, the weight of mint essence is 1650ml, and the weight of banana essence is 550 ml;
and stirring and mixing according to the first stirring parameter set by the workflow.
The first stirring parameters include: the first stirring time and the first stirring speed are 25-35 s, and the first stirring speed is 1.3-1.6 m/s.
S3: granulating by a cutter, namely starting a low-speed cutter according to the workflow, adding pre-prepared starch slurry, and then starting a low-speed stirring cutter and a high-speed cutter according to the time designed by the workflow for granulating; then, step S4 is executed;
starting a low-speed cutter in the wet granulating machine which is processed by the step S2 according to the low-speed cutter parameter set by the working flow;
adding 5.4-7.2 parts of starch slurry with the concentration of 5-10%, and then starting low-speed stirring and high-speed cutting according to the high-speed cutting parameter and the second stirring parameter set by the workflow; the low-speed cutter parameters comprise low-speed cutter speed and low-speed cutter time; the high-speed cutter parameters comprise a high-speed cutter speed and a high-speed cutter time, and the second stirring parameters comprise a second stirring time and a second stirring speed;
in the embodiment, the speed of the low-speed cutter is 1500-2000 rpm, and the time of the low-speed cutter is 40-60 s;
the high-speed cutter speed is 1500-2000 rpm, and the high-speed cutter time is 120-180 s;
the second stirring time is 180s and the second stirring speed is 100-140 rpm;
in the step, 5.4-7.2 parts by weight of starch slurry and hydrotalcite are used as the ratio, for example, on the premise of manufacturing 110 ten thousand sheets of hydrotalcite chewable tablets, 15kg of starch with the required concentration of 8% is required, the starch slurry is manufactured when mixed in step S2, specifically, according to the material part amount required by slurry preparation on a material work order, normal-temperature purified water is weighed in a slurry preparation barrel, the starch is weighed by a weighing module of a storage module to reach the slurry preparation barrel, then the starch is stirred according to the slurry preparation stirring parameters set by a workflow, finally a steam valve is opened to heat the slurry preparation barrel until the starch slurry is completely dissolved, and the main control module controls the closing of the steam valve to obtain the starch slurry with the corresponding concentration;
s4: and (4) drying and packaging, namely transferring the granules obtained in the step (S3) into a fluidized bed dryer, drying according to a working flow, transferring into a total mixing machine, adding magnesium stearate, mixing, and finally tabletting and packaging to obtain the magnesium aluminocarbonate chewable tablets.
Specifically, after step S3 is completed, the discharge port of the wet granulator is automatically opened, and the granules obtained in step S3 reach the turnover bucket according to the route set by the workflow;
meanwhile, the dryer is adjusted to a drying environment according to drying parameters set by the workflow, and then the particles in the turnover barrel are sucked into the dryer for drying; the drying parameters include: drying time and drying environment temperature; in one embodiment, the drying environment temperature is 100-150 ℃ and the drying time is 25-30 minutes;
feeding the dried granules into a main mixer through a route set by a working flow, adding 1-2 parts by weight of magnesium stearate, and mixing according to mixing parameters set by the working flow; the mixing parameters include mixing speed and mixing time, in this embodiment, the mixing speed is 8-10rpm, and the mixing time is 100-;
and then the particles obtained after mixing are transferred to a tablet machine along a route set by a workflow for tabletting, and then the tablets are transferred to an aluminum-plastic-aluminum machine for packaging to obtain the hydrotalcite chewable tablets.
Furthermore, the method of the invention also monitors whether the quality of materials, intermediate products and products in the manufacturing process meets the drug production standard and whether the production environment meets the production standard in real time through ERP, MES and other software, and cleans the appliances in the manufacturing process before and after manufacturing.
While the present invention has been described with reference to the embodiments shown in the drawings, the present invention is not limited to the embodiments, which are illustrative and not restrictive, and it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. An intelligent manufacturing method of a hydrotalcite chewable tablet is characterized by comprising the following steps:
s1: creating a material work order and a workflow, the material work order comprising: the material type, the material quantity and the material putting time, wherein the working flow comprises parameter setting in the manufacturing process; the material types include: hydrotalcite, mannitol, starch and essence; wherein,
the aluminum magnesium carbonate, the mannitol, the starch and the essence are as follows by weight: 253 parts of 215 and 223 parts of 227 parts of 36-48 parts of 1-1.2 parts of sodium chloride;
s2: weighing and feeding, namely automatically conveying the materials into a wet granulation machine in sequence according to the weight according to a pre-established material work order, and stirring and mixing according to a first stirring parameter set by the workflow;
s3: granulating by a cutter, namely starting a low-speed cutter according to the working flow, adding 5.4-7.2 parts of starch slurry with the concentration of 5-10% prepared in advance, and then starting low-speed stirring and a high-speed cutter according to the time designed by the working flow to granulate;
s4: and (5) drying and packaging, namely transferring the granules obtained in the step S3 into a boiling dryer, drying according to a working flow, transferring into a total mixing machine, adding magnesium stearate, mixing, and finally tabletting and packaging to obtain the magnesium aluminocarbonate chewable tablets.
2. The method according to claim 1, wherein the step S2 specifically includes:
according to the material types on the material work order, materials stored in different places reach a weighing center according to distribution paths set by a workflow; the weighing centers comprise a plurality of weighing centers, and one material corresponds to one weighing center independently;
the weighing center is used for weighing the materials according to the weight of the materials on the material work order, and then the materials corresponding to the weight of the materials are conveyed into the wet granulation machine according to the material feeding time sequence by the centralized path set by the workflow;
and stirring and mixing according to a first stirring parameter set by the workflow.
3. The method of claim 2, wherein the first stirring parameter comprises: stirring time and stirring speed, wherein the first stirring time is 25-35 s, and the first stirring speed is 1.3-1.6 m/s.
4. The method according to claim 1, wherein the step S3 specifically comprises the steps of:
starting a low-speed cutter in the wet granulating machine which is processed by the step S2 according to the low-speed cutter parameter set by the working flow;
adding 5.4-7.2 parts of starch slurry with the concentration of 5-10%, and then starting low-speed stirring and high-speed cutting according to the high-speed cutting parameter and the second stirring parameter set by the workflow; the low-speed cutter parameters comprise low-speed cutter speed and low-speed cutter time; the high-speed cutter parameters comprise high-speed cutter speed and high-speed cutter time, and the second stirring parameters comprise second stirring time and second stirring speed.
5. The method according to claim 1, wherein the step S4 specifically comprises the steps of:
after step S3, the wet granulator automatically opens the discharge port, and the granules obtained in step S3 reach the turnover bucket according to the route set by the workflow;
meanwhile, the dryer is adjusted to a drying environment according to drying parameters set by the workflow, and then the particles in the turnover barrel are sucked into the dryer for drying;
feeding the dried granules into a total mixer through a route set by a workflow, adding 1-2 parts by weight of magnesium stearate, and mixing according to mixing parameters set by the workflow; the mixing parameters comprise mixing rotating speed and mixing time;
and (3) transferring the mixed particles into a tablet machine along a route set by a workflow for tabletting, and then transferring into an aluminum-plastic-aluminum machine for packaging to obtain the hydrotalcite chewable tablets.
6. An intelligent manufacturing system of a hydrotalcite chewable tablet, comprising:
the main control module is used for creating a material work order and a workflow and controlling the flow of the system through the material work order and the workflow; the material work order comprises: the material type, the material component and the material putting time, wherein the working flow comprises parameter setting in the manufacturing process; the material types include: hydrotalcite, mannitol, starch and essence;
the storage module is in communication connection with the main control module and is used for separately storing different materials;
the weighing module is connected with the storage module through a conveying device, is connected with the main control module and is used for receiving and weighing materials according to the weight of the materials;
the granulation module is connected with the weighing module through a conveying device, connected with the main control module, used for receiving materials according to the material putting time, and used for stirring, mixing and granulating by a cutter according to parameters set by the workflow;
and the drying and packaging module is connected with the granulating module through a conveying device, connected with the weighing module through a conveying device, connected with the main control module, and used for receiving the granules obtained by the granulating module and drying, mixing, tabletting and packaging according to the parameters set by the workflow.
7. The system of claim 6, wherein the weighing module comprises a plurality of weighing devices, and wherein one weighing device is connected to the stored material in one storage module one by one via the transfer device.
8. The system of claim 6, wherein the parameters set by the workflow include a first stirring parameter for controlling the granulation module to stir, a cutter parameter for controlling the granulation module to cut, a drying parameter for controlling the dry packaging module to dry, and a mixing parameter for controlling the dry packaging module to mix;
the first stirring parameters include: a first stirring time and a first stirring speed;
the cutter parameters include: cutter speed, cutter time;
the drying parameters include: drying time and drying environment temperature;
the mixing parameters include: mixing speed and mixing time.
9. The system of claim 6, further comprising an audit trail module, the storage module, the weighing module and the dry packaging module, for monitoring data in the receiving system in real time and controlling the quality of the product in the system process.
10. The method of claim 8, wherein the first stirring time is 25 to 35s and the first stirring speed is 1.3 to 1.6 m/s.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114699427A (en) * | 2022-04-12 | 2022-07-05 | 广西南宁百会药业集团有限公司 | Hydrotalcite chewable tablet and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087003A (en) * | 1994-10-06 | 2000-07-11 | Centre De Microencapsulation | Method of coating particles and coated spherical particles |
| CN205163661U (en) * | 2015-11-10 | 2016-04-20 | 北京长峰金鼎科技有限公司 | Medicine granule production line |
| CN205672234U (en) * | 2016-04-28 | 2016-11-09 | 四川大冢制药有限公司 | A kind of tablet preparation system preventing from polluting |
| CN109498451A (en) * | 2019-01-02 | 2019-03-22 | 广东容大生物股份有限公司 | Solid pharmaceutical preparation production system |
| CN209108096U (en) * | 2018-06-29 | 2019-07-16 | 华润三九（枣庄）药业有限公司 | A kind of particle medicinal granulating system that integrated level is high |
| CN110131965A (en) * | 2019-05-10 | 2019-08-16 | 特一药业集团股份有限公司 | A kind of bangxiaoan preparation facility for granulating and bangxiaoan production technology |
-
2020
- 2020-12-14 CN CN202011468121.0A patent/CN112494336A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087003A (en) * | 1994-10-06 | 2000-07-11 | Centre De Microencapsulation | Method of coating particles and coated spherical particles |
| CN205163661U (en) * | 2015-11-10 | 2016-04-20 | 北京长峰金鼎科技有限公司 | Medicine granule production line |
| CN205672234U (en) * | 2016-04-28 | 2016-11-09 | 四川大冢制药有限公司 | A kind of tablet preparation system preventing from polluting |
| CN209108096U (en) * | 2018-06-29 | 2019-07-16 | 华润三九（枣庄）药业有限公司 | A kind of particle medicinal granulating system that integrated level is high |
| CN109498451A (en) * | 2019-01-02 | 2019-03-22 | 广东容大生物股份有限公司 | Solid pharmaceutical preparation production system |
| CN110131965A (en) * | 2019-05-10 | 2019-08-16 | 特一药业集团股份有限公司 | A kind of bangxiaoan preparation facility for granulating and bangxiaoan production technology |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114699427A (en) * | 2022-04-12 | 2022-07-05 | 广西南宁百会药业集团有限公司 | Hydrotalcite chewable tablet and preparation method thereof |
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