CN114698633A - Granules containing uniconazole and preparation method thereof - Google Patents
Granules containing uniconazole and preparation method thereof Download PDFInfo
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- CN114698633A CN114698633A CN202210372492.1A CN202210372492A CN114698633A CN 114698633 A CN114698633 A CN 114698633A CN 202210372492 A CN202210372492 A CN 202210372492A CN 114698633 A CN114698633 A CN 114698633A
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- Prior art keywords
- uniconazole
- containing granule
- total weight
- granules
- follows
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- YNWVFADWVLCOPU-MDWZMJQESA-N (1E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol Chemical compound C1=NC=NN1/C(C(O)C(C)(C)C)=C/C1=CC=C(Cl)C=C1 YNWVFADWVLCOPU-MDWZMJQESA-N 0.000 title claims abstract description 106
- 239000008187 granular material Substances 0.000 title claims abstract description 90
- 238000002360 preparation method Methods 0.000 title claims abstract description 38
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 32
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000000080 wetting agent Substances 0.000 claims abstract description 9
- 239000011230 binding agent Substances 0.000 claims abstract description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 23
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 23
- 238000013268 sustained release Methods 0.000 claims description 22
- 239000012730 sustained-release form Substances 0.000 claims description 22
- 239000001856 Ethyl cellulose Substances 0.000 claims description 21
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 21
- 229920001249 ethyl cellulose Polymers 0.000 claims description 21
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 21
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 21
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 19
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 19
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- -1 polyoxyethylene Polymers 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 8
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 239000003337 fertilizer Substances 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 5
- 239000012752 auxiliary agent Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229920005646 polycarboxylate Polymers 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 239000005995 Aluminium silicate Substances 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 235000012211 aluminium silicate Nutrition 0.000 claims description 4
- 229960000892 attapulgite Drugs 0.000 claims description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052625 palygorskite Inorganic materials 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 239000000440 bentonite Substances 0.000 claims description 3
- 229910000278 bentonite Inorganic materials 0.000 claims description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 3
- 239000006229 carbon black Substances 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 229920002261 Corn starch Polymers 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 239000008120 corn starch Substances 0.000 claims description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 2
- 230000000361 pesticidal effect Effects 0.000 abstract description 3
- 239000002131 composite material Substances 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 42
- 230000000052 comparative effect Effects 0.000 description 25
- 230000012010 growth Effects 0.000 description 13
- 241000209094 Oryza Species 0.000 description 12
- 235000007164 Oryza sativa Nutrition 0.000 description 12
- 230000000857 drug effect Effects 0.000 description 12
- 235000009566 rice Nutrition 0.000 description 12
- 239000002245 particle Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- 239000000843 powder Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 239000005648 plant growth regulator Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229920005552 sodium lignosulfonate Polymers 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 241001647875 Pseudoxanthomonas Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000589634 Xanthomonas Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002390 cell membrane structure Anatomy 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000009105 vegetative growth Effects 0.000 description 1
- 238000009333 weeding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The application relates to the field of biotechnology, in particular to uniconazole-containing granules and a preparation method thereof. The composite material consists of the following raw materials in percentage by weight: 0.1-20% of uniconazole, 2-5% of wetting agent, 2-5% of dispersing aid, 2-5% of binder, 5-10% of slow release control agent and the balance of carrier; the uniconazole granules have good structural stability, are not easy to collapse or crack, and can well release pesticide effect when being used for plants, so that the plants can grow better.
Description
Technical Field
The application relates to the field of biotechnology, and more particularly relates to granules containing uniconazole and a preparation method thereof.
Background
Uniconazole is a high-efficiency plant growth regulator and has the functions of sterilization and weeding. The plant growth regulator has the functions of controlling vegetative growth, inhibiting cell elongation, shortening internodes, dwarfing plants and the like, and can promote the growth of lateral buds and the formation of flower buds so as to enhance the stress resistance of the plants. Therefore, the method is suitable for rice and wheat, tillering is increased, the plant height is controlled, and the lodging resistance is improved.
The existing uniconazole preparation is mainly powder, and the uniconazole of the powder is smaller in particle, easy to scatter and inconvenient to transport, so that the uniconazole is prepared into granules which are more convenient to transport and store than the uniconazole, but the particles of the existing granules are easy to collapse due to collision among the particles in the transport process, and the common granules can be directly used for plants (for example, for rice) or used for plants after being dissolved in water, and when the collapsed granules are weighed, the dust is large, so that the use convenience is reduced; when the granules are directly used for plants, due to the fact that the sizes of the particles which are disintegrated are different, the pesticide effect on each plant is different, the growth rate of the plants is easy to be different, and the heights of the plants in the same area are different.
Disclosure of Invention
In order to ensure that the granules release the drug effect well and enable plants to grow better, the application provides granules containing uniconazole and a preparation method thereof.
In a first aspect, the application provides a granule containing uniconazole, which adopts the following technical scheme:
the uniconazole-containing granules comprise the following raw materials in percentage by weight:
uniconazole: 0.1 to 20 percent
Wetting agent: 2 to 5 percent
Dispersing auxiliary agent: 2 to 5 percent
Adhesive: 2 to 5 percent
Sustained-release control agent: 5-10 percent
The balance being carriers.
The content range of the raw material dosage is the preferable content range of the application, and the uniconazole granules obtained in the range have full and slowly disintegrated particles, and can exert preferable pesticide effect when being used for plants, so that the plants can grow better. The uniconazole is light white powder as a somatotropin, can be conducted in a plant body after being absorbed by the root of the plant, stabilizes a cell membrane structure, increases the contents of proline and sugar, and improves the stress resistance of the plant, and the plant can resist cold and drought, so that the prepared uniconazole granules can also improve the stress resistance of the plant.
The carrier can play a bearing effect to uniconazole, be convenient for form uniconazole granule, the binder has the adhesive effect, can bond all raw materials in the uniconazole granule system, and then be convenient for form the stable uniconazole granule of granule structure, reduce the possibility that the uniconazole granule appears disintegrating, and the wetting agent of adding plays the wetting effect, be convenient for powdered uniconazole to moisten, make powdered uniconazole easily adhere to on the carrier, and then further improve the structural stability of uniconazole granule, simultaneously, it not only can promote the dispersibility of uniconazole granule raw materials system to add dispersion auxiliary agent, and can make uniconazole granule have better dispersibility, make this uniconazole granule disperse well when using, it is too slow or too fast to reduce to appear dispersing and influence the absorptive growth of plant.
The slow release control agent can control the release of the drug effect of the uniconazole granules and enable plants to effectively absorb the drug effect of the uniconazole granules, and generally, for example, the uniconazole granules are decomposed too fast, so that the drug effect absorbed by the plants is too much and the plants grow too slowly, or the granules are decomposed too slowly, so that the plants grow too fast and the plants grow too quickly, so that the plants grow. In conclusion, the uniconazole granules can be controlled to release by adopting the sustained-release control agent, the dissolution rate of the uniconazole granules is adjusted, the uniconazole granules can be well absorbed by plants, the utilization of active ingredients of the uniconazole granules is improved, and the plants can grow better.
Preferably, the wetting agent is one or more of alkylphenol polyoxyethylene, fatty alcohol polyoxyethylene and alkyl naphthalene sulfonate.
Alkylphenol ethoxylates, fatty alcohol-polyoxyethylene ether and alkyl naphthalene sulfonate are all surfactants and have a wetting effect, so that the wettability of the uniconazole granule raw material is improved, the raw material can be well mixed, the structural stability of the uniconazole granule is good, and the possibility of cracking or collapsing of the uniconazole granule is reduced.
Preferably, the dispersing aid is one or more of polycarboxylate, sodium dodecyl sulfate, sodium lignin sulfonate and naphthalene sulfonic acid formaldehyde polymer.
The polycarboxylate, the sodium dodecyl sulfate, the sodium lignosulfonate and the naphthalene sulfonic acid formaldehyde polymer have good dispersibility, so that the dispersibility of the uniconazole granules can be improved, and simultaneously, the raw material systems of the uniconazole granules are uniformly mixed.
Preferably, the binder is one or more of xanthan gum, polyvinyl alcohol and polyethylene glycol.
Xanthan gum is also called xanthan gum, Xanthomonas polysaccharide, is a kind of monospore polysaccharide produced by fermentation of pseudoxanthomonas, it has excellent thickening property, suspension property, emulsifying property, water solubility, polyvinyl alcohol has certain adhesive force, polyethylene glycol has non-toxicity, nonirritant, slightly bitter taste, good water solubility, lubricity, moisture retention, dispersivity, adhesive property, and has good intermiscibility with many organic matter components. The raw material system of the uniconazole granules is easy to bond to form a stable structure, and the phenomenon that the particles of the uniconazole granules are cracked or disintegrated in the transportation process of the uniconazole granules is further reduced.
Preferably, the carrier is one or more of kaolin, attapulgite, white carbon black, bentonite, diatomite, light calcium carbonate, corn starch and fertilizer.
The selected carrier can be uniformly mixed with the uniconazole and can be used as the carrier of the uniconazole, so that the uniconazole granules are convenient to form, and the kaolin has the advantages of better plasticity and associativity; the attapulgite clay mainly comprises the cohesive soil, has viscosity and plasticity when being wetted, the white carbon black has super-strong adhesive force and the like, the bentonite has strong adsorption performance, and the diatomite has the advantages of no toxicity, good suspension performance and strong adsorption performance.
Preferably, the slow release control agent consists of hydroxypropyl cellulose, ethyl cellulose and polyvinylpyrrolidone.
Polyvinylpyrrolidone is PVP for short, is a synthetic water-soluble high molecular compound, can be dissolved in water, alcohols and the like, has the functions of bonding, moisture absorption, solubilization or coacervation, and excellent solubility performance and physiological compatibility, and further can enable a slow release control agent to have cohesiveness.
Ethyl cellulose is ethyl ether of cellulose, is one of the most widely used water-insoluble cellulose derivatives, is mainly used as a tablet adhesive, a film coating material and the like due to water insolubility, can also be used as a framework material retarder, is used for preparing various types of framework sustained-release tablets, is used as a mixed material for preparing a coating sustained-release preparation and sustained-release pellets, is used as an encapsulating auxiliary material for preparing sustained-release microcapsules, enables the drug effect to be continuously released, and avoids the premature action of some water-soluble drugs. And the slow release control agent has a slow release effect, can control and reduce the release of the active drug effect of the uniconazole granules, is used for plants, enables the plants to well absorb the drug effect and enables the plants to well grow.
Preferably, the weight ratio of the hydroxypropyl cellulose to the ethyl cellulose to the polyvinylpyrrolidone is 1.5-4.5: 4.5-7.5: 1.
the slow release control agent obtained by the dosage is used for preparing uniconazole granules, so that the obtained uniconazole granules have a good slow release effect, are insoluble and easy to collapse and are used for plants, so that the plants have a good drug effect, and the utilization rate of the uniconazole granules is improved.
Preferably, the sustained-release control agent is prepared by the following steps: weighing hydroxypropyl cellulose, ethyl cellulose and polyvinylpyrrolidone, sequentially dissolving in alcohol, shaking for 20-30min, distilling until the alcohol is completely volatilized, grinding, and sieving with 10-50 mesh sieve to obtain the sustained-release control agent.
Through the steps, the hydroxypropyl cellulose, the ethyl cellulose and the polyvinylpyrrolidone can be fully and uniformly mixed, so that the obtained sustained-release control agent has a good sustained-release effect.
Preferably, the mass fraction of the alcohol is 35-45%. The alcohol in this mass fraction range can dissolve hydroxypropyl cellulose, ethyl cellulose, and polyvinylpyrrolidone well.
In a second aspect, a preparation method of uniconazole-containing granules adopts the following technical scheme:
a preparation method of uniconazole-containing granules comprises the following steps: weighing 0.1-20% of uniconazole, 2-5% of wetting agent, 2-5% of dispersing aid, 5-10% of slow release control agent and 100% of supplemented carrier according to the weight percentage, uniformly mixing, crushing, adding binder, uniformly mixing, extruding and granulating to obtain the uniconazole granules.
In summary, the present application has the following beneficial effects:
1. because the uniconazole is adopted as an effective component, and under the auxiliary action of the wetting agent, the dispersing auxiliary agent, the binder and the carrier, the obtained uniconazole granules have stable particle structure, are not easy to collapse or crack in the transportation or storage process, and can well exert the drug effect when used for plants, improve the utilization rate of the drug effect and ensure that the plants well grow;
2. the application preferably adopts hydroxypropyl cellulose, ethyl cellulose and polyvinylpyrrolidone to form the slow release control agent, can promote the stability of the particle structure of the uniconazole granules, and simultaneously plays a role of slow release of the uniconazole granules, so that when the uniconazole granules are used for plants, the release of effective components is controlled, and the plants further effectively absorb the drug effect of the uniconazole granules to ensure that the plants well grow.
Detailed Description
The present application is further illustrated in detail by reference to the following preparation examples and examples.
Part of raw material sources:
fertilizer (urea compound fertilizer), manufacturer: the total nitrogen content of the chemical technology limited of the Jinan Junda is more than or equal to 46.4 percent (%);
alkylphenol ethoxylates, manufacturer: zhengzhou jue pai hua ltd, model: TX-10;
fatty alcohol-polyoxyethylene ether, manufacturer: guangzhou chemical industry, type: AEO-9;
polycarboxylate, manufacturer: shandong Youso chemical technology Co., Ltd, brand: ecosol/yousol, model: 5040, a heat-insulating material;
polyvinylpyrrolidone, manufacturer: chemical limited, denhakun, goods number: H001.
examples of preparation of sustained Release control Agents
Preparation example 1
A preparation method of a sustained-release control agent comprises the following steps:
weighing 4.5Kg of ethyl cellulose, 4.5Kg of hydroxypropyl cellulose and 1.0Kg of polyvinylpyrrolidone, sequentially adding 35% alcohol by mass fraction for dissolving, oscillating for 20min by ultrasonic wave, distilling at 90 ℃ until the alcohol is completely volatilized, grinding the obtained powder, and sieving by a 10-mesh sieve to obtain the sustained-release control agent.
Preparation example 2
A preparation method of a sustained-release control agent comprises the following steps:
weighing 6Kg of ethyl cellulose, 3Kg of hydroxypropyl cellulose and 1.0Kg of polyvinylpyrrolidone, sequentially adding into 38 percent of alcohol by mass fraction for dissolving, oscillating for 25min by ultrasonic waves, distilling at 90 ℃ until the alcohol is completely volatilized, grinding the obtained powder, and sieving by a 30-mesh sieve to obtain the slow-release control agent.
Preparation example 3
A preparation method of a sustained-release control agent comprises the following steps:
weighing 7.5Kg of ethyl cellulose, 1.5Kg of hydroxypropyl cellulose and 1.0Kg of polyvinylpyrrolidone, sequentially adding into 40 percent of alcohol by mass fraction for dissolving, oscillating for 30min by ultrasonic waves, distilling at 90 ℃ until the alcohol is completely volatilized, grinding the obtained powder, and sieving by a 50-mesh sieve to obtain the slow release control agent.
Preparation of comparative example
Preparation of comparative example 1
Preparation comparative example 1 differs from preparation example 1 in that: the preparation method of comparative example 1 was to weigh 4.5Kg of ethylcellulose, 4.5Kg of hydroxypropylcellulose and 1.0Kg of polyvinylpyrrolidone together and put into a high-speed mixer to mix for 5min, thereby obtaining a sustained-release control agent.
Preparation of comparative example 2
Preparation comparative example 2 differs from preparation example 2 in that: equal amount of polyvinylpyrrolidone is replaced by ethyl cellulose;
preparation of comparative example 3
Preparation comparative example 3 differs from preparation example 2 in that: equal amount of polyvinylpyrrolidone and hydroxypropyl cellulose was replaced by ethyl cellulose.
Preparation of comparative example 4
Preparation comparative example 4 differs from preparation example 2 in that: equal amount of ethyl cellulose and polyvinylpyrrolidone is replaced by hydroxypropyl cellulose.
Preparation of comparative example 5
Preparation comparative example 5 differs from preparation example 2 in that: equal amount of ethyl cellulose and hydroxypropyl cellulose is replaced by polyvinylpyrrolidone.
Examples
Example 1
A preparation method of uniconazole-containing granules comprises the following steps: weighing 4Kg of the sustained-release control agent obtained in preparation example 2, 0.1Kg of uniconazole, 1Kg of alkylphenol polyoxyethylene, 1Kg of fatty alcohol polyoxyethylene ether, 1Kg of polycarboxylate, 1Kg of sodium dodecyl sulfate, 1Kg of sodium lignosulfonate, 20.9Kg of kaolin, 12Kg of attapulgite and 50Kg of fertilizer, uniformly mixing, crushing by using a crusher, then adding 1Kg of polyethylene glycol, 1Kg of polyvinyl alcohol and 1Kg of xanthan gum, and carrying out extrusion granulation by using an extruder to obtain the uniconazole granules.
Examples 2 to 7
Examples 2-7 differ from example 1 in that: the amount of the raw materials used is different, and is specifically shown in table 1;
TABLE 1 EXAMPLES 1-7 amounts (Kg) of starting materials
Examples 8 to 14
Examples 8-14 differ from example 1 in that: the sources of the sustained-release control agents are different, and are specifically shown in table 2;
TABLE 2 raw material content (kg) and source of sustained-release controlling agent of examples 8-14
Comparative example
Comparative example 1
Comparative example 1 differs from example 5 in that: the dosage of the uniconazole is 30 Kg.
Comparative example 2
Comparative example 2 differs from example 5 in that: the slow release control agent is replaced by the carrier in equal amount.
Performance test
The performance testing experiments were conducted for examples 1-14 and comparative examples 1-2, and the specific data are shown in Table 3.
Detection method/test method
1. Stability of
500g of the uniconazole granules obtained in examples 1-14 and comparative examples 1-2 were weighed and stored in a natural environment (normal temperature and pressure), and after one month, whether the particles broke or cracked was observed and recorded, and at the same time, 500g of the uniconazole granules was stored at 50 ℃ and after one month, whether the particles broke or cracked was observed and recorded.
2. Experiment in rice field
Dividing an experimental field (temperature 25 + -0.5 deg.C) where rice seedlings were planted into 18 areas of equal area, each area having 30 rice seedlings (average height 10 + -2 cm, wherein height is a vertical distance between the highest point of the leaf having the highest rice seedling and the ground), applying the uniconazole granules obtained in examples 1-14 and comparative examples 1-2 to 24 areas of rice seedlings (dosage 8 Kg/mu), respectively; the rice seedlings in one area do not need to be added with a medicament and are used as a control group 1; wherein, the rice seedling in another area is fertilized (the fertilizer is urea compound fertilizer, the dosage is 8 kg/mu), the initial average height of the rice in each area is marked as A, the average height of the rice in the seventh day is marked as B, and the average height of the rice in the fourteenth day is marked as C; the average growth rate on the seventh day was 100% of B-a/a, and the average growth rate on the fourteenth day was 100% of C-B/B, as shown in table 3;
TABLE 3 Experimental data for examples 1-14 and comparative examples 1-2
When the amount of uniconazole is too large, the growth rate of the plant is too low to be beneficial to the growth of the plant, which can be seen by combining example 5 and comparative example 1 and combining table 3, and a certain amount of uniconazole can promote the better growth of the plant.
Combining example 5 and comparative example 2 with table 3, it can be seen that, without the addition of the slow-release stabilizer, uniconazole is easily disintegrated or the drug effect of the uniconazole is released too slowly or more rapidly, and the growth rate of the plants at the early stage (the first day to the seventh day) is too slow (the growth rate at the seventh day of comparative example 1 can reach 38.63%); the growth rate of the plants in the later stages (day eight to day fourteen) was too fast to control the granule dilution well.
When the povidone, the hydroxypropyl cellulose and the ethyl cellulose are simply powder-mixed in the sustained-release control agent of example 8, the uniconazole granules obtained are used for the growth efficiency of plants, as can be seen by combining example 8 and example 5 with table 3.
As can be seen by combining examples 9-12 and example 5 and table 3, the growth rate of examples 9-12 is significantly lower than that of example 5, which indicates that the sustained-release control agent obtained by using one or the composition of polyvinylpyrrolidone, hydroxypropyl cellulose and ethyl cellulose in comparative preparation ratios 1-5 has better sustained-release effect when used for preparing uniconazole granules; the growth rate of the uniconazole/povidone iodine complex in the fourteenth day is reduced, which shows that the compound preparation prepared from polyvinylpyrrolidone, hydroxypropyl cellulose and ethyl cellulose has better release capacity, so that the release of the uniconazole granules can be controlled, and plants can absorb the uniconazole better.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The uniconazole-containing granules comprise the following raw materials in percentage by weight:
uniconazole: 0.1 to 20 percent
Wetting agent: 2 to 5 percent
Dispersing auxiliary agent: 2 to 5 percent
Adhesive: 2 to 5 percent
Sustained-release control agent: 5-10 percent
The balance being carriers.
2. The uniconazole-containing granule according to claim 1, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows: the wetting agent is one or more of alkylphenol polyoxyethylene, fatty alcohol polyoxyethylene and alkyl naphthalene sulfonate.
3. The uniconazole-containing granule according to claim 1, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows: the dispersing auxiliary agent is one or more of polycarboxylate, sodium dodecyl sulfate, sodium lignin sulfonate and naphthalene sulfonic acid formaldehyde polymer.
4. The uniconazole-containing granule according to claim 1, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows: the binder is one or more of xanthan gum, polyvinyl alcohol and polyethylene glycol.
5. The uniconazole-containing granule according to claim 1, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows: the carrier is composed of one or more of kaolin, attapulgite, white carbon black, bentonite, diatomite, light calcium carbonate, corn starch and fertilizer.
6. The uniconazole-containing granule according to claim 1, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows: the slow release control agent consists of hydroxypropyl cellulose, ethyl cellulose and polyvinylpyrrolidone.
7. The uniconazole-containing granule according to claim 6, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows: the weight ratio of the hydroxypropyl cellulose to the ethyl cellulose to the polyvinylpyrrolidone is 1.5-4.5: 4.5-7.5: 1.
8. the uniconazole-containing granule according to claim 7, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows: the slow release control agent is prepared by the following steps: weighing ethyl cellulose, hydroxypropyl cellulose and polyvinylpyrrolidone, sequentially dissolving in alcohol, shaking for 20-30min, distilling until the alcohol is completely volatilized, grinding, and sieving with 10-50 mesh sieve to obtain the sustained-release control agent.
9. The uniconazole-containing granule according to claim 8, wherein the weight ratio of the total weight of the uniconazole-containing granule to the total weight of the uniconazole-containing granule is as follows:
preferably, the mass fraction of the alcohol is 35-45%.
10. A process for the preparation of uniconazole-containing granules according to any one of claims 1 to 9, comprising the steps of: weighing 0.1-20% of uniconazole, 2-5% of wetting agent, 2-5% of dispersing aid, 5-10% of slow release control agent and 100% of supplemented carrier according to the weight percentage, uniformly mixing, crushing, adding binder, uniformly mixing, extruding and granulating to obtain the uniconazole granules.
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| CN1951186A (en) * | 2005-10-21 | 2007-04-25 | 北京市农业技术推广站 | Sustained releasing pesticide granule |
| CN101642105A (en) * | 2009-09-04 | 2010-02-10 | 中国农业大学 | Uniconazole water dispersible granules and preparation method thereof |
| CN107258776A (en) * | 2017-06-29 | 2017-10-20 | 山东大农药业有限公司 | A kind of sustained releasing pesticide granule and preparation method thereof |
| CN107864957A (en) * | 2017-11-01 | 2018-04-03 | 河南中威高科技化工有限公司 | Rice growth regulation agent and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951186A (en) * | 2005-10-21 | 2007-04-25 | 北京市农业技术推广站 | Sustained releasing pesticide granule |
| CN101642105A (en) * | 2009-09-04 | 2010-02-10 | 中国农业大学 | Uniconazole water dispersible granules and preparation method thereof |
| CN107258776A (en) * | 2017-06-29 | 2017-10-20 | 山东大农药业有限公司 | A kind of sustained releasing pesticide granule and preparation method thereof |
| CN107864957A (en) * | 2017-11-01 | 2018-04-03 | 河南中威高科技化工有限公司 | Rice growth regulation agent and preparation method thereof |
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Denomination of invention: A granule containing uniconazole and its preparation method Granted publication date: 20230620 Pledgee: Dongying Bank Co.,Ltd. Jinan Branch Pledgor: SHANDONG TANG PU LE CROP SCIENCE CO.,LTD. Registration number: Y2024980003145 |