CN114669258B - A thick material reaction series production line for bio-pharmaceuticals - Google Patents
A thick material reaction series production line for bio-pharmaceuticals Download PDFInfo
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- CN114669258B CN114669258B CN202210308628.2A CN202210308628A CN114669258B CN 114669258 B CN114669258 B CN 114669258B CN 202210308628 A CN202210308628 A CN 202210308628A CN 114669258 B CN114669258 B CN 114669258B
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 58
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 22
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 15
- 239000000463 material Substances 0.000 title description 6
- 238000002425 crystallisation Methods 0.000 claims abstract description 50
- 230000008025 crystallization Effects 0.000 claims abstract description 50
- 239000000376 reactant Substances 0.000 claims abstract description 28
- 239000013078 crystal Substances 0.000 claims abstract description 19
- 239000011345 viscous material Substances 0.000 claims abstract description 18
- 238000001514 detection method Methods 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 238000007789 sealing Methods 0.000 claims abstract description 9
- 230000005540 biological transmission Effects 0.000 claims description 7
- 230000006698 induction Effects 0.000 claims description 5
- 239000012780 transparent material Substances 0.000 claims description 3
- 230000006978 adaptation Effects 0.000 claims description 2
- 235000013547 stew Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 6
- 239000007787 solid Substances 0.000 abstract description 6
- 238000005096 rolling process Methods 0.000 abstract description 4
- 238000003756 stirring Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 241000883990 Flabellum Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0063—Control or regulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/087—Cleaning containers, e.g. tanks by methods involving the use of tools, e.g. brushes, scrapers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B9/00—Presses specially adapted for particular purposes
- B30B9/02—Presses specially adapted for particular purposes for squeezing-out liquid from liquid-containing material, e.g. juice from fruits, oil from oil-containing material
- B30B9/12—Presses specially adapted for particular purposes for squeezing-out liquid from liquid-containing material, e.g. juice from fruits, oil from oil-containing material using pressing worms or screws co-operating with a permeable casing
- B30B9/128—Vertical or inclined screw presses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B9/00—Presses specially adapted for particular purposes
- B30B9/02—Presses specially adapted for particular purposes for squeezing-out liquid from liquid-containing material, e.g. juice from fruits, oil from oil-containing material
- B30B9/12—Presses specially adapted for particular purposes for squeezing-out liquid from liquid-containing material, e.g. juice from fruits, oil from oil-containing material using pressing worms or screws co-operating with a permeable casing
- B30B9/14—Presses specially adapted for particular purposes for squeezing-out liquid from liquid-containing material, e.g. juice from fruits, oil from oil-containing material using pressing worms or screws co-operating with a permeable casing operating with only one screw or worm
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D2009/0086—Processes or apparatus therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention discloses a viscous material reaction series production line for bio-pharmaceuticals, which comprises a reaction kettle main body, a feed inlet, a reactant inlet, a sealing valve, a one-way valve, a conveyor belt, a dragon plate, a sleeve, a standing reactor, a drainage groove plate, an accelerator, an inductor, a sensing door and a rolling rod, wherein the reaction kettle main body is provided with the feed inlet and the reactant inlet, the reaction kettle main body is also provided with the sealing valve, the reaction kettle main body is provided with the one-way valve, and the position of a port of the one-way valve is correspondingly provided with a detection push rod. According to the invention, after the viscous substance and the reactant are fully reacted through the standing reactor arranged in the reaction kettle main body, the viscous substance and the reactant are separated into two forms of solid and liquid, and then the liquid with higher purity is crystallized to obtain the high-purity crystal, so that the reactions of the columns are in a safe and sealed environment, and the purity of the crystal in the continuous crystallization process can be continuously detected.
Description
Technical Field
The invention relates to the technical field of viscous material reaction, in particular to a viscous material reaction series production line for biopharmaceuticals.
Background
The reaction and preparation of various viscous matters in the biopharmaceutical field are carried out by using a reaction kettle which is used in a large amount because of vacuum and aseptic environment in the kettle, but under the condition of guaranteeing aseptic precursors, the reaction condition in the kettle cannot be effectively observed, and finally obtained experimental data is influenced, so that in the process of reusing the reaction kettle, if the poor observation of the reaction condition in the kettle can be overcome, the series production line of the whole reaction can be better improved.
The existing thick material reaction production line only has the stirring, heating and cooling applications of a reaction kettle, the reaction production line is not perfect, intelligent and real-time purity detection of crystals cannot be achieved, for example, the thick material cooling reaction kettle disclosed in the application number 20110628810.1 cannot provide real-time parameter comparison of purity in the whole reaction production line, and qualified purity extracts cannot be conveyed, so that the intelligent and work efficiency improvement cannot be achieved.
Therefore, it is necessary to invent a viscous material reaction series production line for biopharmaceuticals to solve the above problems.
Disclosure of Invention
The invention aims to provide a viscous material reaction series production line for biopharmaceuticals, which aims to solve the problems that the viscous material reaction production line in the technology cannot detect the purity of crystals in real time, and the whole production line and the reaction process cannot be intelligent and efficient.
In order to achieve the above object, the present invention provides the following technical solutions: the utility model provides a viscous material reaction series production line for bio-pharmaceuticals, includes reation kettle main part, pan feeding mouth, reactant entry, sealing valve, check valve, conveyer belt, flood dragon board, sleeve, reactor, drainage groove board, accelerator, inductor, induction door and dwang are stood, be provided with pan feeding mouth and reactant entry in the reation kettle main part, still be provided with the sealing valve in the reation kettle main part, the check valve has been seted up in the reation kettle main part, check valve port position corresponds and is provided with the detection push rod, be connected with display and sensor flood, be provided with crystallization export and turbid liquid outlet in the reation kettle main part, crystallization export position corresponds and is provided with the conveyer belt, the bottom is provided with flood dragon board in the reation kettle main part, flood dragon board bottom fixedly connected with drainage stick and sprocket, sprocket is connected with No. two sprockets on fixedly connected with cylindrical cam, sliding connection has the sleeve on the cylindrical cam, install U type scraper blade on the sleeve, install crystallization board and evenly install on the sensor flood board on the crystallization board, the sensor flood board is stood down in the reactor.
Preferably, the feeding port and the reactant inlet are fixedly connected to the reaction kettle body, the feeding port and the reactant inlet are opposite in direction, and the feeding port and the reactant inlet are provided with manual stop valves, so that the volume of materials in the reaction kettle body is manually controlled.
Preferably, the detection push rod is electrically connected with the sensor and the power supply of the display, the detection push rod is an automatic telescopic rod, and the end part of the detection push rod is provided with a detector, so that the reaction crystallization process and the purity in the reaction kettle main body are detected in real time.
Preferably, the crystallization outlet is funnel-shaped made of transparent materials, the crystallization outlet is in sliding connection with the rectangular induction door, and the quantity of crystals can be directly observed through the crystallization outlet.
Preferably, the diameter of the dragon plate is changed from large to small from top to small, the maximum diameter of the dragon plate is twice the minimum diameter, and under the action of the dragon plate, the solid after the solid-liquid separation of the reactant can be stirred for the second time.
Preferably, the drainage rod is fixedly connected to the transmission shaft of the dragon plate, the transmission shaft of the dragon plate is arranged on the drainage groove plate through a bearing, the length of the cylindrical cam is matched with the length of the crystallization plate, and a sliding rod is arranged between the cylindrical cam and the hollow sleeve.
Preferably, circular through holes are uniformly formed in the crystallization plate, and the surface of the crystallization plate is contacted with the U-shaped scraping plate.
Preferably, the standing reactor is uniformly provided with long strip-shaped holes, the standing reactor is a graph formed by an arc line and a straight line, the drainage groove plate is provided with strip-shaped grooves, and the size of each strip-shaped groove is adaptive to the thickness of the blade of the dragon plate.
In the technical scheme, the invention has the technical effects and advantages that:
1. after the viscous substance and the reactant are fully reacted through a standing reactor arranged in the reaction kettle main body, the viscous substance and the reactant are separated into two forms of solid and liquid, and then the liquid with higher purity is crystallized to obtain high-purity crystals, so that the reactions of the columns are in a safe and sealed environment, and the purity of the crystals in the continuous crystallization process can be continuously detected;
2. The solid and the liquid after the reaction can be respectively conveyed through the dragon plate and the drainage rod, under the acceleration effect, the stirring speed of the dragon plate is accelerated, the efficiency is higher, the centrifugal force born by the drainage rod is larger, the liquid thrown onto the crystallization plate is quicker and more efficient, and the efficiency of obtaining the crystal is higher;
3. through the high temperature crystallization on the crystallization board, the liquid that will throw away to the crystallization board is quick crystallization, and the crystallization thing after the crystallization is constantly scraped by U type scraper blade, is carried the crystallization export, on being carried conveyer belt and ripe production line, whole reaction and the process intellectuality and the aseptic of crystallization.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic perspective view of a roller bar according to the present invention;
FIG. 3 is a schematic view of the internal perspective structure of the main body of the reaction vessel of the present invention;
FIG. 4 is a perspective cross-sectional view of the main body of the reaction vessel of the present invention;
FIG. 5 is a schematic structural view of a crystallization plate according to the present invention;
FIG. 6 is a schematic perspective view of a drainage rod according to the present invention;
FIG. 7 is a reaction scheme of the present invention.
Reference numerals illustrate:
1. A reaction kettle main body; 2. a feed inlet; 3. a reactant inlet; 4. a sealing valve; 5. a one-way valve; 6. detecting a push rod; 7. a display; 8. a sensor; 9. a crystallization outlet; 10. a turbid liquid outlet; 11. a conveyor belt; 12. flood dragon board; 13. a drainage rod; 14. a first sprocket; 15. a chain; 16. a second sprocket; 17. a cylindrical cam; 18. a sleeve; 19. a U-shaped scraping plate; 20. a crystallization plate; 21. standing the reactor; 22. a drainage groove plate; 23. an accelerator; 24. an inductor; 25. a sensing door; 26. a rolling rod.
Detailed Description
In order to make the technical scheme of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to the accompanying drawings.
The invention provides a viscous material reaction series production line for bio-pharmaceuticals, which is shown in fig. 1-7, and comprises a reaction kettle main body 1, a feed inlet 2, a reactant inlet 3, a sealing valve 4, a one-way valve 5, a conveyor belt 11, a dragon plate 12, a sleeve 18, a standing reactor 21, a drainage groove plate 22, an accelerator 23, a sensor 24, a sensor door 25 and a rolling rod 26, wherein the feed inlet 2 and the reactant inlet 3 are arranged on the reaction kettle main body 1, the sealing valve 4 is also arranged on the reaction kettle main body 1, the one-way valve 5 is provided with the one-way valve, the port position of the one-way valve 5 is correspondingly provided with a detection push rod 6, the detection push rod 6 is connected with a display 7 and a sensor 8, the reaction kettle main body 1 is provided with a crystallization outlet 9 and a turbid liquid outlet 10, the position of the crystallization outlet 9 is correspondingly provided with the conveyor belt 11, the bottom of the reaction kettle main body 1 is fixedly provided with the dragon plate 12, the bottom of the dragon plate 12 is fixedly connected with a drainage rod 13 and a first chain wheel 14, the first chain wheel 14 is connected with a second chain wheel 16 through a chain 15, the second chain wheel 16 is fixedly connected with the chain wheel 16, the second chain wheel 16 is fixedly provided with the guide rod 17, the roller wheel 17 is fixedly connected with the crystal plate 17 and the cylindrical sleeve 18 and the cylindrical sleeve 19, the roller is fixedly connected with the cylindrical sleeve 19, the cylindrical sleeve is arranged on the cylindrical sleeve is provided with the cylindrical roller 19, the cylindrical roller 19 and the cylindrical roller is provided with the cylindrical roller 19, the roller is provided with the roller 19, and with the roller is a roller, and has a roller.
The pan feeding mouth 2 and reactant entry 3 are all fixed connection on reation kettle main part 1, and the orientation of pan feeding mouth 2 and reactant entry 3 is opposite to all be provided with manual stop valve on pan feeding mouth 2 and the reactant entry 3, detect push rod 6 and sensor 8 and the power electric connection of display 7, and detect push rod 6 and be automatic telescopic link, and detect push rod 6 tip is provided with the detector.
The crystallization outlet 9 is the funnel shape of transparent material, crystallization outlet 9 and the response door 25 sliding connection of rectangle, flood dragon board 12 is the diameter from big to little change, and flood dragon board 12 maximum diameter is the twice of minimum diameter, drainage stick 13 fixed connection is on the transmission shaft of flood dragon board 12, the transmission shaft of flood dragon board 12 passes through the bearing and installs on drainage groove plate 22, the length looks adaptation of cylindrical cam 17 and crystallization board 20, and there is the slide bar between cylindrical cam 17 and the hollow sleeve 18.
The crystallization plate 20 is evenly provided with circular through holes, and crystallization plate 20 surface and U type scraper 19 contact, evenly offer rectangular hole on the reactor of standing 21, and the reactor of standing 21 is the figure that arc and straight line are constituteed, is provided with the bar groove on the drainage groove board 22, and its bar groove's size and flood dragon board 12 flabellum thickness are suited.
The working principle of the invention is as follows:
referring to the accompanying drawings 1-3 in the specification, when the device is used, raw material sticky matters and reactants are firstly conveyed into a reaction kettle main body 1 through a feed inlet 2 and a reactant inlet 3, and a stop valve on the feed inlet 2 and the reactant inlet 3 can be opened and closed manually to convey the materials;
Conveying the sticky matters and the reactants to a standing reactor 21 in a reaction kettle main body 1, separating solids from liquid after standing and reacting on the standing reactor 21, fixing and repeatedly stirring by a dragon plate 12, screening out active ingredients in the solids, flowing out along a notch of a drainage channel plate 22, and flowing out the rest turbid liquid along a turbid liquid outlet 10;
Under the action of the drainage rod 13 and the accelerator 23, the reacted liquid is subjected to great centrifugal force and is continuously thrown out onto the crystallization plate 20, and is rapidly heated and crystallized by the crystallization plate 20, so that a crystal with higher purity is obtained;
Referring to fig. 3-6 of the specification, when the device is used, a crystal obtained through a crystallization plate 20 is driven by a first chain wheel 14, a chain 15 and a second chain wheel 16 which are connected on a transmission shaft of a dragon plate 12 rotating at high speed, so that a cylindrical cam 17 rotates at high speed, a sleeve 18 drives the cylindrical cam 17 to slide up and down along the direction of a surface groove of the cylindrical cam 17, and the crystal on the surface of the crystallization plate 20 is scraped and accumulated at a crystallization outlet 9;
After the crystallization outlet 9 is fully piled up, the sensor 24 obtains a signal, the sensor door 25 is opened, the crystallization falls onto the conveyor belt 11 along the rolling rod 26, and the crystallization is conveyed to a mature production line;
of course, in the process of being continuously reacted and crystallized in the reaction kettle main body 1, a signal can be sent to the detection push rod 6 through the sensor 8, the detection push rod 6 is pushed into the reaction kettle main body 1, the one-way valve 5 is opened and stretches into the crystallization plate 20, the crystal on the crystallization plate 20 is detected, the detected data is displayed by the display 7 in real time, and when the detection push rod 6 can detect the crystal with proper purity, the crystal accumulated at the crystallization outlet 9 is judged to be qualified.
Claims (6)
1. A viscous material reaction series production line for bio-pharmaceuticals, includes reation kettle main part (1), pan feeding mouth (2), reactant entry (3), sealing valve (4), check valve (5), conveyer belt (11), flood dragon board (12), sleeve (18), stew reactor (21), drainage groove board (22), accelerator (23), inductor (24), induction door (25) and dwang (26), its characterized in that: the reactor comprises a reactor main body (1), a feeding port (2) and a reactant inlet (3) are arranged on the reactor main body (1), a sealing valve (4) is further arranged on the reactor main body (1), a check valve (5) is arranged on the reactor main body (1), a detection push rod (6) is correspondingly arranged at the port position of the check valve (5), a display (7) and a sensor (8) are connected to the detection push rod (6), a crystallization outlet (9) and a turbid liquid outlet (10) are arranged on the reactor main body (1), a conveyor belt (11) is correspondingly arranged at the position of the crystallization outlet (9), a dragon plate (12) is arranged at the inner bottom of the reactor main body (1), a drainage rod (13) and a first sprocket (14) are fixedly connected to the bottom of the dragon plate (12), a second sprocket (16) is connected to the first sprocket (14) through a chain (15), a cylindrical cam (17) is fixedly connected to the second sprocket (16), a sleeve (18) is connected to the cylindrical cam (17) in a sliding manner, a U (18) is arranged on the cylindrical cam (17), a U (18) is connected to the U (19) and is fixedly connected to the crystal plate (20) through a scraper (20), the utility model discloses a flood dragon board, including flood dragon board (12), crystal outlet (9), flood dragon board (12) bottom is installed on drainage groove board (22), install accelerator (23) on flood dragon board (12), be provided with inductor (24) and induction door (25) on crystal outlet (9), evenly be provided with dwang (26) in crystal outlet (9), drainage stick (13) fixed connection is on the transmission shaft of flood dragon board (12), the transmission shaft of flood dragon board (12) passes through the bearing and installs on drainage groove board (22), the length of cylinder cam (17) and the length looks adaptation of crystallization board (20), just there is the slide bar between cylinder cam (17) and hollow sleeve (18), evenly be provided with circular through-hole on crystallization board (20), just crystallization board (20) surface and U type scraper blade (19) contact.
2. A viscous material reaction series production line for biopharmaceuticals according to claim 1, wherein: the reaction kettle comprises a reaction kettle body (1), a feeding port (2) and a reactant inlet (3), wherein the feeding port (2) and the reactant inlet (3) are fixedly connected to the reaction kettle body (1), the feeding port (2) and the reactant inlet (3) are opposite in direction, and manual stop valves are arranged on the feeding port (2) and the reactant inlet (3).
3. A viscous material reaction series production line for biopharmaceuticals according to claim 1, wherein: the detection push rod (6) is electrically connected with the sensor (8) and a power supply of the display (7), the detection push rod (6) is an automatic telescopic rod, and a detector is arranged at the end part of the detection push rod (6).
4. A viscous material reaction series production line for biopharmaceuticals according to claim 1, wherein: the crystallization outlet (9) is funnel-shaped made of transparent materials, and the crystallization outlet (9) is in sliding connection with the rectangular induction door (25).
5. A viscous material reaction series production line for biopharmaceuticals according to claim 1, wherein: the diameter of the dragon plate (12) is changed from large to small from top to small, and the maximum diameter of the dragon plate (12) is twice the minimum diameter.
6. A viscous material reaction series production line for biopharmaceuticals according to claim 1, wherein: the novel water dispenser is characterized in that long strip-shaped holes are uniformly formed in the standing reactor (21), the standing reactor (21) is a graph formed by an arc line and a straight line, a strip-shaped groove is formed in the drainage groove plate (22), and the size of the strip-shaped groove is matched with the thickness of a fan blade of the dragon plate (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210308628.2A CN114669258B (en) | 2022-03-25 | 2022-03-25 | A thick material reaction series production line for bio-pharmaceuticals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210308628.2A CN114669258B (en) | 2022-03-25 | 2022-03-25 | A thick material reaction series production line for bio-pharmaceuticals |
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| Publication Number | Publication Date |
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| CN114669258A CN114669258A (en) | 2022-06-28 |
| CN114669258B true CN114669258B (en) | 2024-05-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210308628.2A Active CN114669258B (en) | 2022-03-25 | 2022-03-25 | A thick material reaction series production line for bio-pharmaceuticals |
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| WO2009151159A1 (en) * | 2008-06-10 | 2009-12-17 | Kndt&I Co., Ltd | Crystallization reaction apparatus for preparation of massive crystalline particles and crystalline separation processing system |
| CN205472715U (en) * | 2016-03-31 | 2016-08-17 | 青岛阿库卡稀有金属有限公司 | Rehenic acid ammonium crystallization purification device |
| KR20170093015A (en) * | 2016-02-04 | 2017-08-14 | 웰이앤씨 주식회사 | A reactor for crystallization |
| CN206701252U (en) * | 2017-03-22 | 2017-12-05 | 深圳市九明药业有限公司 | A kind of reactor of fully recovery crystallization |
| CN208426688U (en) * | 2018-06-20 | 2019-01-25 | 开封明仁药业有限公司 | Crystallizing tank is used in a kind of detection |
| CN209865362U (en) * | 2019-03-01 | 2019-12-31 | 盘锦百事达新材料有限公司 | Crystallization equipment for solid-liquid separation |
| CN211612710U (en) * | 2019-12-31 | 2020-10-02 | 湖北凌安科技有限公司 | Automatic centrifugal powder making device for raw materials of water reducing agent |
| CN113289372A (en) * | 2021-06-23 | 2021-08-24 | 江苏派克斯特纤维素有限公司 | Evaporative crystallization device for processing non-edible salt |
-
2022
- 2022-03-25 CN CN202210308628.2A patent/CN114669258B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151159A1 (en) * | 2008-06-10 | 2009-12-17 | Kndt&I Co., Ltd | Crystallization reaction apparatus for preparation of massive crystalline particles and crystalline separation processing system |
| KR20170093015A (en) * | 2016-02-04 | 2017-08-14 | 웰이앤씨 주식회사 | A reactor for crystallization |
| CN205472715U (en) * | 2016-03-31 | 2016-08-17 | 青岛阿库卡稀有金属有限公司 | Rehenic acid ammonium crystallization purification device |
| CN206701252U (en) * | 2017-03-22 | 2017-12-05 | 深圳市九明药业有限公司 | A kind of reactor of fully recovery crystallization |
| CN208426688U (en) * | 2018-06-20 | 2019-01-25 | 开封明仁药业有限公司 | Crystallizing tank is used in a kind of detection |
| CN209865362U (en) * | 2019-03-01 | 2019-12-31 | 盘锦百事达新材料有限公司 | Crystallization equipment for solid-liquid separation |
| CN211612710U (en) * | 2019-12-31 | 2020-10-02 | 湖北凌安科技有限公司 | Automatic centrifugal powder making device for raw materials of water reducing agent |
| CN113289372A (en) * | 2021-06-23 | 2021-08-24 | 江苏派克斯特纤维素有限公司 | Evaporative crystallization device for processing non-edible salt |
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| Publication number | Publication date |
|---|---|
| CN114669258A (en) | 2022-06-28 |
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