CN114653092A - Extraction method of industrial hemp, obtained industrial hemp essential oil and application thereof - Google Patents
Extraction method of industrial hemp, obtained industrial hemp essential oil and application thereof Download PDFInfo
- Publication number
- CN114653092A CN114653092A CN202011445097.9A CN202011445097A CN114653092A CN 114653092 A CN114653092 A CN 114653092A CN 202011445097 A CN202011445097 A CN 202011445097A CN 114653092 A CN114653092 A CN 114653092A
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- CN
- China
- Prior art keywords
- industrial hemp
- electronic cigarette
- extraction
- essential oil
- extraction method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/12—Molecular distillation
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/02—Pretreatment
- C11B1/04—Pretreatment of vegetable raw material
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
- C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/12—Refining fats or fatty oils by distillation
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Abstract
The invention provides an extraction method of industrial hemp, which firstly passes through supercritical CO2Extracting to obtain extract, and collecting the obtained light components by molecular distillation. The invention also provides industrial hemp essential oil and application thereof. The invention also provides the electronic cigarette oil. The extraction method provided by the invention adopts supercritical CO2The electronic cigarette oil provided by the invention has the advantages of full and exquisite fragrance, no miscellaneous gas, no introduction of harmful ingredients such as addictive substances and the like, simple and convenient preparation method, low cost, no addiction and other toxic and side effects, and very good application prospect.
Description
Technical Field
The invention relates to the field of plant extraction, in particular to an extraction method of industrial hemp, obtained industrial hemp essential oil and application of the industrial hemp essential oil, and also relates to electronic cigarette oil.
Background
Industrial hemp, also known as hemp, has an addictive substance Tetrahydrocannabinol (THC) content of less than 0.3% and does not have the value of extracting toxic components or directly taking the toxic components as drugs, so that the industrial hemp can be legally planted on a large scale and industrially developed and utilized.
The modern detection technology shows that the components contained in industrial hemp are complicated in types and complex in composition, at least 483 monomeric compounds are identified, more than 60 cannabinoids are specific to industrial hemp plants, and the industrial hemp plants have proved to have obvious pharmacological activities such as spasm resistance, rheumatoid arthritis resistance, anxiety resistance and the like and huge industrial development value. The U.S. Food and Drug Administration (FDA) approved the drug Epidiolex with Cannabidiol (CBD) as the first active in 2018. In addition to cannabinoids, other components of industrial cannabis include lipids, flavones, terpenes, hydrocarbons, acyclic macrophenols, alkaloids, lignins, etc., and some of these components have been reported to have superior pharmacological activity, such as geranylflavones, terpenes, etc., with antioxidant, anti-inflammatory, bactericidal, etc. effects.
At present, the extraction of industrial hemp is mainly directed at the cannabinoids, especially CBD, for example, Chinese patent CN 110367581A discloses a composition containing cannabinol components extracted from industrial hemp and the application thereof in tobacco products, wherein the composition contains 30-90% of CBD and 1-25% of CBDV, which can relax the muscles of smokers, improve the mood, and improve and enrich the aroma of cigarettes. For example, chinese patent CN 110373264a discloses a composition for tobacco products, which contains industrial hemp essential oil extracted by steam distillation, wherein the industrial hemp essential oil contains a large amount of monoterpene and sesquiterpene substances, and can relieve fatigue, stabilize mood, and improve the quality of aroma of smoke after being used in tobacco products. Therefore, the industrial hemp has extremely high utilization value, and further development of application of the industrial hemp is needed to realize maximization of value utilization.
Disclosure of Invention
In order to further develop the utilization value of industrial hemp, an object of the present invention is to provide an extraction method of industrial hemp, from which a specific extract of ingredients is obtained and utilized.
The invention also aims to provide the industrial hemp essential oil obtained by the extraction method and application thereof.
Still another object of the present invention is to provide an e-liquid.
The extraction method of industrial cannabis provided by the invention comprises the following steps:
s1: supercritical CO is carried out by taking industrial hemp flowers and leaves as raw materials and propylene glycol as entrainer2Extracting to obtain an extract; and
s2: and (3) performing molecular distillation on the extract, and collecting the obtained light component.
Industrial hemp contains many components, volatile oil substances determine the aroma, and cellulose, lignin, pectin, sugar, polyphenols, inorganic salts and other components have a remarkable influence on the taste. In the extraction method provided by the invention, supercritical CO is adopted2The extraction can directionally extract low-polarity substances from industrial hemp, and the obtained extract contains volatile oil, oligosaccharide,Flavone, cannabinoid, pigment, saponin, fatty acid, etc., and small amount of pigment and wax. Then, subjecting the extract to molecular distillation, detecting by gas chromatography-mass spectrometry (GC-MS), and performing qualitative determination according to NIST11 library search with matching degree of more than or equal to 80%, wherein the light component obtained by subjecting the extract to molecular distillation mainly contains terpenes, alcohols, aldehydes and ketones, esters, and nitrogen-oxygen heterocycles with high volatility (such as beta-caryophyllene, myrcene, caryophyllene, camphene, decane, dodecane, 2, 3-butanediol, benzyl alcohol, phenethyl alcohol, maltitol, 2-hexen-4-ol, 6-methyl-5-heptenone, 1-octen-3-one, citral, benzaldehyde, butyl acetate, 1-hydroxy-2-propyl acetate, panthenol, methyl pyrrolidone, pyridine, acetylfuran, tetrahydrofuran, and the like, Indole, etc.), the content of cannabinoids is low, and the obtained recombinant component mainly comprises oligosaccharide, flavone, cannabinoid, pigment, saponin, etc. Therefore, the extraction method provided by the invention can fully extract volatile substances in industrial hemp and effectively remove irritant components affecting the taste.
In addition, the extraction method of the invention uses propylene glycol as entrainer, the extraction efficiency of propylene glycol is higher compared with common fatty alcohol such as methanol, ethanol and the like, and the propylene glycol can also be used as a reagent in certain application fields (such as electronic cigarette oil), so when the obtained extract is applied to the fields, no extra solvent removal step is needed, the process is simplified, and the problem of organic solvent residue can be avoided.
The extraction method can also avoid the reactions of oxidation, polymerization, hydrolysis and the like of partial substances caused by long-time and high-temperature distillation of the traditional steam distillation method or organic solvent distillation method, thereby damaging the effective components of the essential oil.
After the extraction method disclosed by the invention is used for extracting, the aroma substances in the light components are fully reserved, the light components can be used as essential oil, the essential oil has rich and intense aromatic odor, and is transparent in color, extremely low in viscosity, good in fluidity and better in applicability.
In the extraction method of the present inventionIn the step S1, the extraction pressure can be 10-50 MPa, the extraction temperature can be 30-50 ℃, the extraction time can be 2-4 h, the mass of the entrainer can be 0.8-1.2 times of the mass of the industrial hemp flowers and leaves, and the supercritical CO can be used for extracting the industrial hemp flowers and leaves2The flow rate of (a) can be 10-50 times/h of the mass of the industrial hemp leaves. In some preferred embodiments, the entrainer may be of equal quality to the industrial hemp flower and leaf. In other preferred embodiments, supercritical CO2The flow rate of (a) can be 10-30 times/h of the mass of the industrial hemp flowers and leaves, namely when the mass of the industrial hemp flowers and leaves is 0.1kg, supercritical CO is adopted2The flow rate of (A) may be 1 to 3 kg/h.
In the extraction method, the molecular distillation can be scraper type molecular distillation, the vacuum degree can be 0.01-1 MPa, the distillation temperature can be 60-100 ℃, and the rotation speed of a scraper can be 150-350 r/min.
In the extraction method of the present invention, the step S1 may further include performing supercritical CO2And drying and crushing the industrial hemp flowers and leaves before extraction, and sieving the crushed industrial hemp flowers and leaves through a No. 1-4 sieve.
The invention also provides industrial hemp essential oil which is prepared by the extraction method in any one of the technical schemes.
The invention also provides the use of the industrial hemp essential oil as a fragrance additive. The industrial hemp essential oil provided by the invention hardly contains tetrahydrocannabinol, has low content of cannabinoids, is mainly composed of small molecular volatile substances, is free from addiction, is safe and reliable, and can be used as a fragrance additive to be added into tobacco products, electronic cigarette oil, daily chemical products, foods and medicines, and has wide application. In some preferred embodiments, the industrial cannabis essential oil of the invention can be used as a single flavor material in e-liquid tobacco, or can be used with other flavor components in e-liquid tobacco. In other preferred embodiments, the industrial cannabis essential oil of the invention can be used in traditional tobacco products, such as directly added to cut tobacco, or added to tobacco products as a bead-blasting according to conventional methods.
The invention also provides electronic cigarette oil which comprises 0.1-1 wt% of the industrial hemp essential oil in any one of the technical schemes.
The electronic cigarette oil provided by the invention can contain any additive component in the field of electronic cigarette oil besides the industrial hemp essential oil, and can also be prepared by only using the industrial hemp essential oil provided by the invention as an essence substance and a solvent. In some preferred embodiments, in order to further improve the mouthfeel of the electronic cigarette oil, 1-10 wt% of a perfume base and the balance of a polyol solvent can be further included.
In the electronic cigarette oil, the essence base can contain 5-15 wt% of essence and the balance of polyol solvent, and the essence can be selected from at least two of methyl pyrrolidone, p-hydroxyphenylethanol, maltol, dihydroactinidiolide, 4-hydroxy-beta-dihydrodamascone and megastigmatrienone. In some preferred embodiments, the essence may include 0.5 to 2 parts by weight of methyl pyrrolidone, 0.5 to 2 parts by weight of p-hydroxyphenylethanol, 0.5 to 2 parts by weight of maltol, 0.5 to 2 parts by weight of dihydroactinidiolide, 0.5 to 2 parts by weight of 4-hydroxy- β -dihydrodamascenone, and 0.1 to 2 parts by weight of megastigmatrienone. In some more preferred embodiments, the essence may include 0.8 to 1.2 parts by weight of methyl pyrrolidone, 0.8 to 1.2 parts by weight of p-hydroxyphenylethanol, 0.8 to 1.2 parts by weight of maltol, 0.8 to 1.2 parts by weight of dihydroactinidiolide, 0.8 to 1.2 parts by weight of 4-hydroxy- β -dihydrodamascone, and 0.8 to 1.2 parts by weight of megastigmatrienone. The fragrance base composition of the invention is blended according to the sensory characteristics of industrial hemp essential oil, and can play a role in modifying and coordinating the whole fragrance and aroma.
In the electronic cigarette oil, the polyalcohol solvent can be any solvent in the field of electronic cigarette oil. In some preferred embodiments, the polyol solvent may be selected from at least one of glycerol, propylene glycol, polyethylene glycol.
The extraction method provided by the invention adopts supercritical CO2The extraction technology and the molecular distillation technology are combined, so that the fragrant substances in the industrial hemp can be fully and effectively extracted, and the obtained essential oil is rich and has good fragranceHas strong fragrance, transparent color and low viscosity, and can be used as fragrance additive with fragrance enhancing effect in tobacco, daily chemical, medicine, food, etc. The extraction method provided by the invention has the advantages of simple process and mild conditions, and is suitable for large-scale industrial application.
The electronic cigarette oil provided by the invention is added with the industrial hemp essential oil and matched with the special composition of the essence base, has full and exquisite fragrance and no miscellaneous gas, does not introduce harmful ingredients such as addictive substances and the like, can be used for conventional electronic cigarettes and heating non-combustible cigarettes, and effectively improves the comfort and harmony of novel tobacco products. The electronic cigarette oil provided by the invention has the advantages of simple preparation method, low cost, no addiction or other toxic and side effects, and very good application prospect.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following specific examples.
The propylene glycol, the glycerol and the polyethylene glycol used in the invention are all in medical grade, and the polyethylene glycol is polyethylene glycol-200 (PEG-200).
The industrial hemp used in the invention is legally planted and comes from pharmaceutical limited company of Han union of Yunnan.
The content of Tetrahydrocannabinol (THC) is detected by High Performance Liquid Chromatography (HPLC), and the detection method is as follows:
chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a filling agent; taking 0.1% formic acid water solution (volume concentration) as a mobile phase A and 0.1% formic acid acetonitrile solution (volume concentration) as a mobile phase B, and carrying out gradient elution according to the following table; the detection wavelength was 220 nm.
Control solution: taking a proper amount of THC reference substance, precisely weighing, and preparing into solution containing THC0.03 mg per 1mL with methanol.
The determination method comprises the following steps: respectively and precisely measuring 10 μ L of each of the reference solution and the sample solution, injecting into a liquid chromatograph, recording chromatogram, and calculating peak area according to external standard method if there is a chromatographic peak in the chromatogram of the sample solution consistent with the retention time of the main peak in the THC reference solution.
Example 1
(1) Pulverizing industrial hemp flower and leaf 100g, sieving with No. 1 sieve, and supercritical CO treatment with propylene glycol of the same mass as entrainer2Extracting under 10MPa at 30 deg.C for 2 hr with supercritical CO2The flow rate of the extract is 1kg/h, and an extract is obtained.
(2) And (2) performing scraper type molecular distillation on the extract obtained in the step (1), wherein the vacuum degree is 0.01MPa, the distillation temperature is 60 ℃, and the rotation speed of a distillation scraper is 150r/min, so as to respectively obtain a light component and a heavy component, wherein the light component is the industrial hemp essential oil, and the industrial hemp essential oil is transparent in color, has a strong aromatic smell and is extremely low in viscosity.
No THC component was detected, indicating that the essential oil product of this example was not addictive.
Example 2
(1) Pulverizing industrial hemp flower and leaf 100g, sieving with No. 2 sieve, and performing supercritical CO with propylene glycol of the same mass as entrainer2Extracting under 30MPa at 40 deg.C for 3 hr with supercritical CO2The flow rate of the extraction liquid is 2kg/h, and an extract is obtained.
(2) And (2) performing scraper type molecular distillation on the extract obtained in the step (1), wherein the vacuum degree is 0.1MPa, the distillation temperature is 80 ℃, and the rotation speed of a distillation scraper is 250r/min, so as to respectively obtain a light component and a heavy component, wherein the light component is the industrial hemp essential oil, and is transparent in color, rich in aromatic odor and extremely low in viscosity.
No THC component was detected, indicating that the essential oil product of this example was not addictive.
Example 3
(1) Pulverizing industrial hemp flower and leaf 100g, sieving with No. 3 sieve, and supercritical CO treatment with propylene glycol of the same mass as entrainer2Extracting under 50MPa at 50 deg.C for 4 hr with supercritical CO2The flow rate of the extraction liquid is 3kg/h, and an extract is obtained.
(2) And (2) performing scraper type molecular distillation on the extract obtained in the step (1), wherein the vacuum degree is 0.9MPa, the distillation temperature is 100 ℃, and the rotation speed of a distillation scraper is 350r/min, so as to respectively obtain a light component and a heavy component, wherein the light component is the industrial hemp essential oil, and is transparent in color, rich in aromatic odor and extremely low in viscosity.
No THC component was detected, indicating that the essential oil product of this example was not addictive.
Application example 1 electronic cigarette oil
Taking 1g of methyl pyrrolidone, 1g of p-hydroxyphenylethanol, 1g of maltol, 1g of dihydroactinidiolide, 1g of 4-hydroxy-beta-dihydrodamascenone and 1g of megastigmatrienone, and adding glycerol to 100g for dissolving to obtain a perfume base.
0.2g of industrial hemp essential oil obtained in example 1, 8.8g of essence, 61g of glycerin and 30g of propylene glycol are taken, stirred and mixed uniformly to obtain the electronic cigarette oil.
Application example 2 electronic cigarette liquid
Taking 1g of methyl pyrrolidone, 1g of p-hydroxyphenylethanol, 1g of maltol, 1g of dihydroactinidiolide, 1g of 4-hydroxy-beta-dihydrodamascenone and 1g of megastigmatrienone, and adding propylene glycol to 100g for dissolving to obtain a perfume base.
0.5g of industrial hemp essential oil obtained in example 2, 4.5g of essence, 67g of glycerin and 28g of propylene glycol are taken, stirred and mixed uniformly to obtain the electronic cigarette oil.
Application example 3 electronic cigarette liquid
Taking 1g of methyl pyrrolidone, 1g of p-hydroxyphenylethanol, 1g of maltol, 1g of dihydroactinidiolide, 1g of 4-hydroxy-beta-dihydrodamascenone and 1g of megastigmatrienone, and adding propylene glycol to 100g for dissolving to obtain a perfume base.
0.8g of industrial hemp essential oil obtained in example 3, 2.2g of essence, 67g of glycerin and 20030 g of polyethylene glycol are taken, stirred and mixed uniformly to obtain the electronic cigarette oil.
Comparative example
Crushing 100g of industrial hemp flowers and leaves, sieving the crushed industrial hemp flowers and leaves by a No. 2 sieve, adding 8 times of water according to the mass ratio, soaking for 1h, heating the soaked industrial hemp flowers and leaves to 150 ℃ under high pressure for 2h, collecting water-oil mixed steam, removing a water layer to obtain the industrial hemp steam distillation essential oil which has common fragrance, deep color, high viscosity and poor fluidity.
Taking 1g of methyl pyrrolidone, 1g of p-hydroxyphenylethanol, 1g of maltol, 1g of dihydroactinidiolide, 1g of 4-hydroxy-beta-dihydrodamascenone and 1g of megastigmatrienone, and adding propylene glycol to 100g for dissolving to obtain a perfume base.
0.2g of industrial hemp-water vapor distilled essential oil, 8.8g of essence, 61g of glycerol and 30g of propylene glycol are taken, stirred and mixed uniformly to obtain the electronic cigarette oil.
The results of the evaluation with reference to the electronic cigarette sensory evaluation method of Chinese patent CN 106617277A are shown in Table 1.
TABLE 1 results of the test of comparative examples and examples
| Sample (I) | Irritation property | Satisfaction feeling | Feeling of dryness | Characteristic style | Quality of fragrance | Amount of fragrance | In total |
| Comparative example | 6 | 7 | 7 | 5 | 6.5 | 7 | 38.5 |
| Example 1 | 8 | 7 | 7 | 8 | 8 | 8 | 46 |
| Example 2 | 8 | 7 | 6.5 | 8 | 8 | 8.5 | 46 |
| Example 3 | 8.5 | 6.5 | 7 | 8.5 | 8.5 | 8.5 | 47.5 |
The results in table 1 show that compared with the traditional steam distillation method, the essential oil prepared by the extraction method of the invention has obvious aroma, prominent aroma, little irritation and offensive odor after being added with the electronic cigarette oil, and has better overall impression quality for the testee.
Unless otherwise defined, all terms used herein have the meanings commonly understood by those skilled in the art.
The described embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention, and various other substitutions, alterations, and modifications may be made by those skilled in the art within the scope of the present invention.
Claims (10)
1. A method for extracting industrial hemp, which is characterized by comprising the following steps:
s1: supercritical CO is carried out by taking industrial hemp flowers and leaves as raw materials and propylene glycol as entrainer2Extracting to obtain an extract; and
s2: and (3) performing molecular distillation on the extract, and collecting the obtained light component.
2. The extraction method according to claim 1, wherein in the step S1, the extraction pressure is 10-50 MPa, the extraction temperature is 30-50 ℃, the extraction time is 2-4 h, the mass of the entrainer is 0.8-1.2 times of the mass of the industrial hemp flowers and leaves, and the supercritical CO is adopted2The flow rate of (a) is 10-50 times/h of the mass of the industrial hemp leaves.
3. The extraction method according to claim 1 or 2, wherein in the step S2, the molecular distillation is scraper type molecular distillation, the vacuum degree is 0.01-1 MPa, the distillation temperature is 60-100 ℃, and the rotation speed of a scraper is 150-350 r/min.
4. The extraction method according to any one of claims 1 to 3, wherein the step S1 further comprises performing supercritical CO extraction2And drying and crushing the industrial hemp flowers and leaves before extraction, and sieving the crushed industrial hemp flowers and leaves through a No. 1-4 sieve.
5. An industrial hemp essential oil obtained by the extraction method according to any one of claims 1 to 4.
6. Use of the industrial cannabis essential oil of claim 5 as a fragrance additive; preferably, the flavor additive is for addition to a tobacco product, an electronic cigarette oil, a daily chemical, a food product, or a pharmaceutical product.
7. An electronic cigarette oil, characterized by comprising 0.1-1 wt% of the industrial hemp essential oil of claim 5.
8. The electronic cigarette liquid according to claim 7, further comprising 1-10 wt% of a perfume base and the balance of a polyol solvent.
9. The electronic cigarette liquid of claim 8, wherein the perfume base comprises 5-15 wt% of essence and the balance of polyol solvent, wherein the essence is selected from at least two of methyl pyrrolidone, p-hydroxyphenylethanol, maltol, dihydroactinidiolide, 4-hydroxy-beta-dihydrodamascone and megastigmatrienone; preferably, the essence comprises, by weight, 0.5-2 parts of methyl pyrrolidone, 0.5-2 parts of p-hydroxyphenylethanol, 0.5-2 parts of maltol, 0.5-2 parts of dihydroactinidiolide, 0.5-2 parts of 4-hydroxy-beta-dihydrodamascenone and 0.1-2 parts of megastigmatrienone.
10. The electronic cigarette liquid of claim 8 or 9, wherein the polyol solvent is at least one selected from glycerol, propylene glycol, and polyethylene glycol.
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| CN111876245A (en) * | 2020-06-25 | 2020-11-03 | 黑龙江纳贝斯抗冠素生物科技有限公司 | A method for purifying hemp oil from hemp leaf |
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| CN111876245A (en) * | 2020-06-25 | 2020-11-03 | 黑龙江纳贝斯抗冠素生物科技有限公司 | A method for purifying hemp oil from hemp leaf |
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