CN114650995A - 作为bcl6抑制剂的[1,4]氧杂氮杂䓬[2,3-c]喹啉酮衍生物 - Google Patents

作为bcl6抑制剂的[1,4]氧杂氮杂䓬[2,3-c]喹啉酮衍生物 Download PDF

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Publication number
CN114650995A
CN114650995A CN202080072281.5A CN202080072281A CN114650995A CN 114650995 A CN114650995 A CN 114650995A CN 202080072281 A CN202080072281 A CN 202080072281A CN 114650995 A CN114650995 A CN 114650995A
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China
Prior art keywords
methyl
amino
difluoro
quinolin
cyclopropyl
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Pending
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CN202080072281.5A
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English (en)
Chinese (zh)
Inventor
本杰明·理查德·贝莱妮
阿尔菲·布伦南
贵明·杰克·张
欧文·亚历山大·戴维斯
爱丽丝·克莱尔·哈恩登
斯文·霍尔德
罗斯玛丽·哈克威尔
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Cancer Research Institute Royal Cancer Hospital
Cancer Research Technology Ltd
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Cancer Research Institute Royal Cancer Hospital
Cancer Research Technology Ltd
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Publication of CN114650995A publication Critical patent/CN114650995A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
CN202080072281.5A 2019-10-14 2020-10-14 作为bcl6抑制剂的[1,4]氧杂氮杂䓬[2,3-c]喹啉酮衍生物 Pending CN114650995A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201914860A GB201914860D0 (en) 2019-10-14 2019-10-14 Inhibitor compounds
GB1914860.0 2019-10-14
PCT/GB2020/052588 WO2021074620A1 (en) 2019-10-14 2020-10-14 [1,4]oxazepino[2,3-c]qui noli none derivatives as blc6 inhibitors

Publications (1)

Publication Number Publication Date
CN114650995A true CN114650995A (zh) 2022-06-21

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CN202080072281.5A Pending CN114650995A (zh) 2019-10-14 2020-10-14 作为bcl6抑制剂的[1,4]氧杂氮杂䓬[2,3-c]喹啉酮衍生物

Country Status (13)

Country Link
US (1) US12528826B2 (enExample)
EP (1) EP4045510B1 (enExample)
JP (1) JP7668273B2 (enExample)
KR (1) KR20220083761A (enExample)
CN (1) CN114650995A (enExample)
AU (1) AU2020365518B2 (enExample)
CA (1) CA3157716A1 (enExample)
ES (1) ES3047908T3 (enExample)
GB (1) GB201914860D0 (enExample)
IL (1) IL292182B1 (enExample)
MX (1) MX2022004419A (enExample)
WO (1) WO2021074620A1 (enExample)
ZA (1) ZA202203520B (enExample)

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PE20250756A1 (es) 2022-06-06 2025-03-13 Treeline Biosciences Inc Degradadores bifuncionales de bcl6 de quinolona triciclica
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KR20250023481A (ko) 2022-06-13 2025-02-18 트리라인 바이오사이언시스, 인크. 1,8-나프티리딘-2-온 이종이작용성 bcl6 분해제
KR20240161027A (ko) * 2023-05-03 2024-11-12 인제대학교 산학협력단 BTK 분해제 및 Bcl-6 분해제를 포함하는 암의 예방 또는 치료용 약학적 조성물
AU2024331309A1 (en) * 2023-09-01 2026-03-19 Treeline Biosciences, Inc. Tricyclic quinolone bcl6 bifunctional degraders

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AU2020365518B2 (en) 2026-04-23
JP2022551950A (ja) 2022-12-14
EP4045510A1 (en) 2022-08-24
IL292182A (en) 2022-06-01
KR20220083761A (ko) 2022-06-20
WO2021074620A1 (en) 2021-04-22
ZA202203520B (en) 2025-09-25
EP4045510C0 (en) 2025-07-30
WO2021074620A9 (en) 2021-06-17
MX2022004419A (es) 2022-08-08
US12528826B2 (en) 2026-01-20
GB201914860D0 (en) 2019-11-27
AU2020365518A1 (en) 2022-04-14
ES3047908T3 (en) 2025-12-05
EP4045510B1 (en) 2025-07-30
IL292182B1 (en) 2026-02-01
US20240217987A1 (en) 2024-07-04
JP7668273B2 (ja) 2025-04-24
CA3157716A1 (en) 2021-04-22

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