CN114650835A - 高效杀灭耐药病害菌的药物及在抑制耐药病害菌中的应用 - Google Patents

高效杀灭耐药病害菌的药物及在抑制耐药病害菌中的应用 Download PDF

Info

Publication number
CN114650835A
CN114650835A CN202080072646.4A CN202080072646A CN114650835A CN 114650835 A CN114650835 A CN 114650835A CN 202080072646 A CN202080072646 A CN 202080072646A CN 114650835 A CN114650835 A CN 114650835A
Authority
CN
China
Prior art keywords
tpad
active ingredient
tpi
composition
qsec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080072646.4A
Other languages
English (en)
Inventor
于日磊
王岩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ocean University of China
Original Assignee
Ocean University of China
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201910983456.7A external-priority patent/CN110680904A/zh
Application filed by Ocean University of China filed Critical Ocean University of China
Publication of CN114650835A publication Critical patent/CN114650835A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

本发明提供了高效杀灭耐药病害菌的药物及在抑制耐药病害菌中的应用。具体地，本发明提供了一种用于杀灭或抑制病害菌的组合物，其包括由第一活性成分TPAD和第二活性成分QseC/B信号通路抑制剂组成的活性组合。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN202080072646.4A 2019-10-16 2020-06-11 高效杀灭耐药病害菌的药物及在抑制耐药病害菌中的应用 Pending CN114650835A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201910983456.7A CN110680904A (zh) 2019-10-16 2019-10-16 一种抗野生荣杆菌的药物及应用
CN2019109834567 2019-10-16
CN2020100683808 2020-01-21
CN202010068380 2020-01-21
PCT/CN2020/095683 WO2021073131A1 (zh) 2019-10-16 2020-06-11 高效杀灭耐药病害菌的药物及在抑制耐药病害菌中的应用

Publications (1)

Publication Number Publication Date
CN114650835A true CN114650835A (zh) 2022-06-21

Family

ID=75537635

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080072646.4A Pending CN114650835A (zh) 2019-10-16 2020-06-11 高效杀灭耐药病害菌的药物及在抑制耐药病害菌中的应用

Country Status (2)

Country Link
CN (1) CN114650835A (zh)
WO (1) WO2021073131A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113846034B (zh) * 2021-10-27 2024-01-16 河北科技大学 一种产酶溶杆菌l-43及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252841B2 (en) * 2007-10-19 2012-08-28 The Board Of Regents Of The University Of Texas System Methods of inhibiting bacterial virulence and compounds relating thereto
CN101857562A (zh) * 2010-05-12 2010-10-13 中国人民解放军第四军医大学 具有抑制细菌毒力作用的QseC配体衍生物的合成方法
KR20240025050A (ko) * 2016-07-29 2024-02-26 임베드 바이오사이언시스 아이엔씨. 상처 치유를 위한 방법 및 조성물
WO2018140518A1 (en) * 2017-01-24 2018-08-02 Flagship Pioneering, Inc. Compositions and related methods for controlling vector-borne diseases
AU2018213284B2 (en) * 2017-01-24 2024-03-28 Flagship Pioneering Innovations V, Inc. Compositions and related methods for agriculture
CN108623659B (zh) * 2018-03-17 2021-09-14 中国海洋大学 一种氨基酸全部选用d型氨基酸的抗菌肽合成方法
CN110680904A (zh) * 2019-10-16 2020-01-14 中国海洋大学 一种抗野生荣杆菌的药物及应用

Also Published As

Publication number Publication date
WO2021073131A1 (zh) 2021-04-22

Similar Documents

Publication Publication Date Title
Lu et al. D-and unnatural amino acid substituted antimicrobial peptides with improved proteolytic resistance and their proteolytic degradation characteristics
CN101801995B (zh) 抗菌肽
Čeřovský et al. Lucifensin, a novel insect defensin of medicinal maggots: synthesis and structural study
US9079937B2 (en) Dendrimeric peptides, pharmaceutical compositions and methods of using the same
Liu et al. Design of novel antimicrobial peptide dimer analogues with enhanced antimicrobial activity in vitro and in vivo by intermolecular triazole bridge strategy
Lin et al. Semisynthesis and biological evaluation of xanthone amphiphilics as selective, highly potent antifungal agents to combat fungal resistance
US11046730B2 (en) Antimicrobial compositions
US10738093B2 (en) Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
US7745390B2 (en) Antimicrobial peptides
Hicks Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted Cα amino acids
KR20130078561A (ko) 라이신 및 트립토판 잔기가 ４번 반복된 신규한 항균 및 항진균 펩타이드 및 이의 용도
Kumar et al. Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization
Rajasekaran et al. The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities
Guo et al. Feleucin-K3 analogue with an α-(4-Pentenyl)-Ala substitution at the key site has more potent antimicrobial and antibiofilm activities in vitro and in vivo
Hu et al. Lysine stapling screening provides stable and low toxic cationic antimicrobial peptides combating multidrug-resistant bacteria in vitro and in vivo
He et al. Optimized proteolytic resistance motif (DabW)-based U1-2WD: A membrane-induced self-aggregating peptide to trigger bacterial agglutination and death
Ahn et al. Poly-lysine peptidomimetics having potent antimicrobial activity without hemolytic activity
He et al. Boosting stability and therapeutic potential of proteolysis-resistant antimicrobial peptides by end-tagging β-naphthylalanine
Cárdenas-Martínez et al. Effects of substituting arginine by lysine in bovine lactoferricin derived peptides: pursuing production lower costs, lower hemolysis, and sustained antimicrobial activity
He et al. Lysine-tethered stable bicyclic cationic antimicrobial peptide combats bacterial infection in vivo
Ragonis-Bachar et al. Natural antimicrobial peptides self-assemble as α/β chameleon amyloids
WO2014107042A1 (ko) 헬리코박터 파일로리균의 리보좀 단백질 l1으로부터 유래된 신규한 항생 펩타이드 및 이의 용도
CN114650835A (zh) 高效杀灭耐药病害菌的药物及在抑制耐药病害菌中的应用
WO2018115877A2 (en) Compositions and methods of treatment
Bonvin et al. Antimicrobial Peptide–Peptoid Hybrids with and without Membrane Disruption

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination