CN1146449A - Preparation method for amino-acid zinc and application thereof - Google Patents
Preparation method for amino-acid zinc and application thereof Download PDFInfo
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- CN1146449A CN1146449A CN 94114854 CN94114854A CN1146449A CN 1146449 A CN1146449 A CN 1146449A CN 94114854 CN94114854 CN 94114854 CN 94114854 A CN94114854 A CN 94114854A CN 1146449 A CN1146449 A CN 1146449A
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- zinc
- inner complex
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- acid zinc
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Abstract
The present invention belongs to an amino-acid zinc chelate complex. Said invented chelate complex is very easy to be absorbed, so that it is greatly superior to enriching agents of zinc sulfate, zinc lactate and zinc gluconate for zinc-supplementing food which are not easy to be absorbed through cell membrane. Said invention implements a larger improvement on the Eu Patent 240288, and makes its product more stable and easy to be absorbed by organism.
Description
The invention belongs to the preparation method and the application thereof of amino-acid zinc.
Children lack zinc has become a social concern in some countries, and at present about the food fortifier such as the zinc supplementation agent such as zinc sulfate, zinc lactate and grape acid saccharic acid zinc of zinc, it is very low by the yield that organism absorbs, poor effect.Its major cause is that its anionic existence has hindered the process that is absorbed of zinc because these compounds all are salts.At small bowel, zine ion at first homopolypeptide, dipeptides or certain seed amino acid forms inner complex, wholely then enters cell paste by various cytolemma, and last chelating chain disconnects, and zine ion is by various enzyme combinations, forms zinc enzyme amino acid and is absorbed by organism.
European patent Eu, Patent 240288 discloses the technology for preparing this kind inner complex, thinks only to have or not anionic inner complex to be absorbed by cell by molecular film.Some investigators of China also once did the theoretical investigation of this respect, thought that each metal ion species has only with amino acid formation neutral chelate, could be transported to metal ion in the biomass cells and go.And the molecular weight of this inner complex is the smaller the better, because of this inner complex is made the as a whole biomass cells that passes through, and just triglycine the zinc [(C that Eu Patent 240288 obtains
2O
2NH
4)
3Zn], be the amino-acid zinc inner complex and this patent obtains, its molecular weight is the former 2/3rds.
The objective of the invention is to replace at present used zinc sulfate, zinc lactate and grape acid saccharic acid zinc to improve the assimilation effect of organism, be beneficial to the absorption of organism with the molecular weight that reduces inner complex with the inner complex amino-acid zinc.
The present invention is that the synthesis technique to Eu Patent 240288 has carried out bigger improvement, and the feed ratio of amino acid and zinc (mol ratio) was reduced to 2: 1 from 3: 1.At Eu Patent 240288 aspect the synthesis technique is after reaction finishes, and mixed solution will leave standstill 14 hours, is heated to 70 ℃ then, carries out spraying drying, obtains the inner complex of triglycine.And the present invention is after reaction finishes, and mixed solution is left standstill, and mixed solution is concentrated, and adds isopyknic alcohol then, waits to occur post precipitation and filters, and the white crystal that obtains is that amino-acid zinc inner complex productive rate is 50-70%; Perhaps after reaction finishes, mixed solution is left standstill, concentrate then, promptly occur the plate crystal of white after the cooling, after filtration, behind the recrystallization, just obtain the amino-acid zinc inner complex.
The present invention improves the synthesis technique of Eu Patent 240288, obtained the inner complex of the minimum amino-acid zinc of molecular weight, its fusing point is than the fusing point height (fusing point of triglycine zinc is 209 ℃) of triglycine zinc, it be one littler than triglycine zinc molecular weight, and more stable, the easier inner complex that is absorbed by organism.
Example 1
Add distilled water in beaker, with amino acid dissolving, treat that complete molten back adds zinc oxide, leave standstill after the stirring, after heating concentrated on the electric furnace, cool to room temperature added alcohol to mixed solution with this mixed solution, and stirred and just have a large amount of white crystals to separate out.Leave standstill after-filtration, obtain white crystal, behind recrystallization, just can obtain the amino-acid zinc inner complex.
Example 2
In beaker, add distilled water,, treat that complete molten back adds zinc oxide the amino acid dissolving.Leave standstill after the stirring.This mixed solution is stopped heating after heating on the electric furnace concentrates, be that the adularescent crystal is separated out after the cooling slowly, and after filtration, just can obtain with example 1 identical product behind the recrystallization, productive rate is 50-70%.
Claims (2)
1. the inner complex of an amino-acid zinc, when it is characterized in that preparing this inner complex, be to prepare amino acid solution earlier, add zinc oxide to this solution then, stir, leave standstill, after mixed solution is concentrated, add isopyknic alcohol then, wait to occur post precipitation and filter and recrystallization, promptly obtain white crystalline amino-acid zinc inner complex.Perhaps after reaction finishes, mixed solution is left standstill, concentrates, after the cooling, separate out the plate crystal of white, reach recrystallization after filtration after, obtain the amino-acid zinc inner complex.The amino-acid zinc inner complex can be used for making the additive of the additive of the cereal of infant or baby food and pregnancy period and lactating women, diabetic subject, male sexual dysfunction, cardiovascular patient and goods thereof and beverage, milk-product, to reach the purpose of zinc supplementation.
2. press claim 1 said amino-acid zinc inner complex and manufacture method thereof, it is characterized in that when feeding intake, amino acid and inorganic salt are dissolved in the distilled water, add zinc oxide then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94114854 CN1146449A (en) | 1994-08-15 | 1994-08-15 | Preparation method for amino-acid zinc and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94114854 CN1146449A (en) | 1994-08-15 | 1994-08-15 | Preparation method for amino-acid zinc and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1146449A true CN1146449A (en) | 1997-04-02 |
Family
ID=5037226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94114854 Pending CN1146449A (en) | 1994-08-15 | 1994-08-15 | Preparation method for amino-acid zinc and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1146449A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732811B (en) * | 2005-08-10 | 2010-12-22 | 刘志仁 | Biochemical fresh-keeping nutritious liquid |
| CN102127144A (en) * | 2011-04-14 | 2011-07-20 | 兰州理工大学 | Neotame-calcium chelate and preparation method thereof |
| CN101062913B (en) * | 2007-06-05 | 2013-01-23 | 重庆大学 | Preparation method of hydroxyproline-zinc chelate complex |
| CN103739509A (en) * | 2014-01-09 | 2014-04-23 | 山东祥维斯生物科技有限公司 | Industrial production and preparation process of glycine chelated manganese |
| CN104095242A (en) * | 2014-07-15 | 2014-10-15 | 广州大学 | Composite zinc selenium polypeptide compound and preparation method thereof |
| CN108383746A (en) * | 2018-04-26 | 2018-08-10 | 江西和泽生物科技有限公司 | A kind of preparation method of glycine zine chelate |
| CN108936149A (en) * | 2018-05-21 | 2018-12-07 | 胡宪蕴 | A kind of compound replenishers of multielement containing nanometer selenium and application |
| CN116769237A (en) * | 2023-08-22 | 2023-09-19 | 广州双一乳胶制品有限公司 | Condom and preparation method thereof |
-
1994
- 1994-08-15 CN CN 94114854 patent/CN1146449A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732811B (en) * | 2005-08-10 | 2010-12-22 | 刘志仁 | Biochemical fresh-keeping nutritious liquid |
| CN101062913B (en) * | 2007-06-05 | 2013-01-23 | 重庆大学 | Preparation method of hydroxyproline-zinc chelate complex |
| CN102127144A (en) * | 2011-04-14 | 2011-07-20 | 兰州理工大学 | Neotame-calcium chelate and preparation method thereof |
| CN103739509A (en) * | 2014-01-09 | 2014-04-23 | 山东祥维斯生物科技有限公司 | Industrial production and preparation process of glycine chelated manganese |
| CN104095242A (en) * | 2014-07-15 | 2014-10-15 | 广州大学 | Composite zinc selenium polypeptide compound and preparation method thereof |
| CN104095242B (en) * | 2014-07-15 | 2016-04-13 | 广州大学 | A kind of composite zinc selenium polypeptide compound and preparation method thereof |
| CN108383746A (en) * | 2018-04-26 | 2018-08-10 | 江西和泽生物科技有限公司 | A kind of preparation method of glycine zine chelate |
| CN108936149A (en) * | 2018-05-21 | 2018-12-07 | 胡宪蕴 | A kind of compound replenishers of multielement containing nanometer selenium and application |
| CN116769237A (en) * | 2023-08-22 | 2023-09-19 | 广州双一乳胶制品有限公司 | Condom and preparation method thereof |
| CN116769237B (en) * | 2023-08-22 | 2023-11-28 | 广州双一乳胶制品有限公司 | Condom and preparation method thereof |
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