CN114642689A - Liver-protecting sobering-up medicine and its production method - Google Patents

Liver-protecting sobering-up medicine and its production method Download PDF

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CN114642689A
CN114642689A CN202210395044.3A CN202210395044A CN114642689A CN 114642689 A CN114642689 A CN 114642689A CN 202210395044 A CN202210395044 A CN 202210395044A CN 114642689 A CN114642689 A CN 114642689A
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parts
powder
extract
liver
sobering
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娄国豪
张峰铄
周鲁帝
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Shenzhen Deyintang Biotechnology Co ltd
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Shenzhen Deyintang Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a liver-protecting sobering-up medicine which is prepared from the following raw materials in parts by weight: 5 parts of ginseng, 30 parts of pueraria flower, 10 parts of pseudo-ginseng, 10 parts of acanthopanax, 100 parts of pueraria powder, 2 parts of antrodia camphorata extract powder, 40 parts of phellinus linteus extract powder, 50 parts of agaricus blazei extract powder, 10 parts of grape tea polyphenol, 100 parts of starch and 70 parts of edible gum. The invention has the effects of promoting qi circulation, removing stasis, relieving swelling and relieving flatulence, is suitable for symptoms such as hypochondriac pain, yellow and swollen face, abdominal mass and the like after drinking, and can decompose alcohol concentration and relieve symptoms such as dizziness, vomiting and the like caused by overhigh alcohol concentration by using ginseng, kudzuvine flower, kudzuvine root, pseudo-ginseng and acanthopanax root traditional Chinese medicines in the medicine after a human body takes a large amount of alcohol.

Description

Liver-protecting sobering-up medicine and its production method
Technical Field
The invention relates to the field of sobering-up medicines, in particular to a liver-protecting sobering-up medicine and a production method thereof.
Background
Excessive drinking is very harmful to the body, alcohol can inhibit the respiratory center of brain delay to cause respiratory arrest, various vitamin deficiencies can be caused to indirectly cause damage to various nervous systems, long-term large-scale drinking can cause fat accumulation in the liver to cause fatty liver, gastric ulcer, damage to the nervous system, cerebral cortex atrophy and the like, and long-term large-scale drinking can not avoid a series of diseases such as liver cirrhosis and the like. The alcohol is discharged out of the body in time after a large amount of alcohol is drunk inevitably so as to reduce the harm of the alcohol to the body. Publication No. CN101554423B discloses an anti-hangover pharmaceutical preparation and a preparation method thereof, which can have an anti-hangover effect, but the injury to the body after drinking is still in place.
Disclosure of Invention
The invention mainly aims to provide a liver-protecting sobering-up medicine and a production method thereof, which can effectively solve the problems mentioned in the background technology.
In order to achieve the purpose, the invention adopts the technical scheme that:
a liver-protecting sobering-up medicine is prepared from the following raw materials in parts by weight: 5 parts of ginseng, 30 parts of pueraria flower, 10 parts of pseudo-ginseng, 10 parts of acanthopanax, 100 parts of pueraria powder, 2 parts of antrodia camphorata extract powder, 40 parts of phellinus linteus extract powder, 50 parts of agaricus blazei extract powder, 10 parts of grape tea polyphenol, 100 parts of starch and 70 parts of edible gum.
Further, the components of the grape tea polyphenol are tea polyphenol, grape seed extract and vitamin C.
Furthermore, the kudzu root powder is prepared by selecting kudzu root, and particularly, the kudzu root with obvious expansion, rich appearance and high powder content is selected for processing the kudzu root powder.
Further, the ginseng is selected from Gynura latifolia or Gynura bicolor, especially from Gynura latifolia or Gynura bicolor produced in Dandong.
Further, the acanthopanax senticosus is selected as a young bud which has just grown, particularly young buds which have just grown from late 4 to late 5 months.
The liver-protecting sobering-up medicine and the production method thereof have the following production steps:
the method comprises the following steps: putting 5 parts of ginseng, 30 parts of pueraria flower, 10 parts of pseudo-ginseng and 10 parts of acanthopanax root into a decocting machine, decocting for 1 hour with strong fire, decocting for 2 hours with slow fire, and filtering to obtain a traditional Chinese medicine decoction after the decoction is finished;
step two: uniformly mixing 100 parts of radix puerariae powder, 2 parts of antrodia camphorata extraction powder, 40 parts of phellinus linteus extraction powder, 50 parts of agaricus blazei extraction powder and 100 parts of starch, sequentially adding 10 parts of grape tea polyphenol and the traditional Chinese medicine decoction prepared in the first step in the mixing process, then adding 70 parts of edible gum as an adhesive, mixing to obtain a granulation raw material of the sobering medicine, and finally placing the granulation raw material of the sobering medicine in a granulator to obtain the sobering medicine tablet.
The method further comprises a preparation step of antrodia camphorata extract powder, wherein after the surface of antrodia camphorata is cleaned and dried, the antrodia camphorata extract powder is crushed to be below 18 microns by adopting an ultramicro crushing technology to obtain antrodia camphorata powder, the antrodia camphorata powder is treated at the low temperature of minus 30 ℃ for 24 hours, after the low temperature treatment for 24 hours, laser wall breaking treatment is adopted, the antrodia camphorata powder is placed in an ethanol solution after the laser wall breaking treatment and is subjected to microwave oscillation to obtain the ethanol solution containing the antrodia camphorata extract, and then the ethanol solution containing the antrodia camphorata extract is dried to obtain the antrodia camphorata extract powder.
Further, the method comprises a preparation step of phellinus igniarius extraction powder, wherein the surface of phellinus igniarius is cleaned and then crushed, the crushed phellinus igniarius is soaked in an ethanol solution with the concentration of 80%, a supernatant is taken to obtain an extract I, the remaining residue is filtered to obtain a remaining supernatant which is an extract II, the extract I and the extract II are mixed to obtain a phellinus igniarius extract, and the phellinus igniarius extract is dried to obtain the phellinus igniarius extraction powder.
Further, the method comprises a preparation step of the agaricus blazei extract powder, wherein the agaricus blazei is dried in the air and then ground into powder, the agaricus blazei is ground into powder and then placed in an environment with the temperature of minus 30 ℃ to be processed at low temperature for 24 hours, laser wall breaking processing is adopted after the low temperature processing for 24 hours, the agaricus blazei is placed in ethanol solution after the laser wall breaking processing and subjected to microwave oscillation to obtain ethanol solution containing the agaricus blazei extract, and then the ethanol solution containing the agaricus blazei extract is dried to obtain the agaricus blazei extract powder.
Further, the method comprises a preparation step of kudzu root powder, which comprises the steps of firstly using a water gun to wash out silt impurities on the surface of kudzu root and in a crack, then cutting off rattan, tail hair and lateral roots by using a blade, then scraping off root bark, rinsing clean by using clear water, crushing kudzu root by using a crusher after the kudzu root is rinsed clean, crushing the kudzu root by using a crusher after the kudzu root is crushed, filtering to obtain kudzu root powder slurry after the kudzu root is crushed, sieving the kudzu root powder slurry by using 80-mesh, 100-mesh and 120-mesh screens in sequence to remove large-particle impurities, then using the kudzu root powder slurry to enter a sedimentation tank, stirring the kudzu root powder slurry in the sedimentation tank, adding 10% old slurry water into the kudzu root slurry during stirring, stirring for 10-60 minutes, standing for 10-12 hours to naturally separate and precipitate the impurities and the kudzu root powder, sucking out upper water after the kudzu root powder is completely precipitated, then adding clear water into wet kudzu root powder and stirring rapidly, dissolving radix Puerariae powder in water, filtering the slurry containing radix Puerariae powder with double-layer gauze, removing impurities at the bottom layer, allowing the slurry to enter the next-stage sedimentation tank, continuously precipitating and separating, shoveling the finally obtained wet radix Puerariae powder out of the sedimentation tank, putting into a clean cloth bag, hoisting the wet cloth bag with a rope, draining off clear water, breaking into small pieces, putting into a mesh screen paved with clean white cotton cloth, and drying with hot air in a fruit and vegetable dryer to obtain the final product radix Puerariae powder.
Compared with the prior art, the invention has the following beneficial effects:
the invention has the effects of promoting qi circulation, removing stasis, relieving swelling and relieving flatulence, is suitable for symptoms such as hypochondriac pain, yellow and swollen face, abdominal mass and the like after drinking, and can decompose alcohol concentration and relieve symptoms such as dizziness, vomiting and the like caused by overhigh alcohol concentration by using ginseng, kudzuvine flower, kudzuvine root, pseudo-ginseng and acanthopanax root traditional Chinese medicines in the medicine after a human body takes a large amount of alcohol.
Meanwhile, the medicine is added with antrodia camphorata extraction powder, phellinus linteus extraction powder and agaricus blazei murill extraction powder, wherein the antrodia camphorata has the function of reducing alcoholic damage to the liver, and meanwhile, the antrodia camphorata contains rich triterpenes and polysaccharides and has the curative effects of protecting the liver, promoting the regeneration of liver cells and resisting liver cancer; phellinus igniarius has the effects of promoting blood circulation, stopping bleeding, resolving fluid retention and stopping diarrhea; agaricus blazei Murill has high anticancer activity, and has effects of enhancing cell immunity, tranquilizing mind, etc.
The medicine is added with the grape tea polyphenol, the main components of the grape tea polyphenol are the tea polyphenol, the grape seed extract and the vitamin C, the grape tea polyphenol can effectively reduce the oxidation of ethanol into acetaldehyde, remove the poison of Z aldehyde, alkane free radicals and the like, the generated strong antioxidation can stimulate antialcoholism factors (the activity of ethanol dehydrogenase and acetaldehyde dehydrogenase) in the liver of a human body, accelerate the decomposition of alcohol in blood, and eliminate the damage of an ester peroxide compound malondialdehyde generated during the decomposition of the alcohol to the liver.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
A liver-protecting sobering-up medicine is prepared from the following raw materials in parts by weight: 5 parts of ginseng, 30 parts of pueraria flower, 10 parts of pseudo-ginseng, 10 parts of acanthopanax, 100 parts of pueraria powder, 2 parts of antrodia camphorata extract powder, 40 parts of phellinus linteus extract powder, 50 parts of agaricus blazei extract powder, 10 parts of grape tea polyphenol, 100 parts of starch and 70 parts of edible gum. The tea polyphenol comprises tea polyphenol, grape seed extract and vitamin C, wherein the kudzu root powder is prepared from kudzu root, especially from kudzu root with obvious root tuber expansion and rich appearance, the kudzu root powder with powder content is prepared from kudzu root, the ginseng is prepared from Stichopus japonicus or Stichopus japonicus, especially from Stichopus japonicus or Stichopus japonicus produced in Dandong city, the acanthopanax is prepared from tender bud which just grows, especially from late ten days of 4 months to 5 months.
The liver-protecting sobering-up medicine can relieve symptoms such as dizziness, vomit and the like caused by overhigh alcohol concentration and reduce the damage of alcohol to the liver.
A liver-protecting sobering-up medicine and a production method thereof, the production steps are as follows: the method comprises the following steps: putting 5 parts of ginseng, 30 parts of pueraria flower, 10 parts of pseudo-ginseng and 10 parts of acanthopanax root into a decocting machine, decocting for 1 hour with strong fire, decocting for 2 hours with slow fire, and filtering to obtain a traditional Chinese medicine decoction after the decoction is finished; step two: uniformly mixing 100 parts of radix puerariae powder, 2 parts of antrodia camphorata extraction powder, 40 parts of phellinus linteus extraction powder, 50 parts of agaricus blazei extraction powder and 100 parts of starch, sequentially adding 10 parts of grape tea polyphenol and the traditional Chinese medicine decoction prepared in the first step in the mixing process, then adding 70 parts of edible gum as an adhesive, mixing to obtain a granulation raw material of the sobering medicine, and finally placing the granulation raw material of the sobering medicine in a granulator to obtain the sobering medicine tablet.
The method further comprises a preparation step of antrodia camphorata extract powder, wherein after the surface of antrodia camphorata is cleaned and dried, the antrodia camphorata extract powder is crushed to be below 18 microns by adopting an ultramicro crushing technology to obtain antrodia camphorata powder, the antrodia camphorata powder is treated at the low temperature of minus 30 ℃ for 24 hours, after the low temperature treatment for 24 hours, laser wall breaking treatment is adopted, the antrodia camphorata powder is placed in an ethanol solution after the laser wall breaking treatment and is subjected to microwave oscillation to obtain the ethanol solution containing the antrodia camphorata extract, and then the ethanol solution containing the antrodia camphorata extract is dried to obtain the antrodia camphorata extract powder. Antrodia camphorata has the function of reducing alcoholic damage to the liver, and simultaneously, the Antrodia camphorata contains rich triterpenes and polysaccharides and has the curative effects of protecting the liver, promoting the regeneration of liver cells and resisting liver cancer.
Further, the method comprises a preparation step of phellinus igniarius extraction powder, wherein the surface of phellinus igniarius is cleaned and then crushed, the crushed phellinus igniarius is soaked in an ethanol solution with the concentration of 80%, a supernatant is taken to obtain an extract I, the remaining residue is filtered to obtain a remaining supernatant which is an extract II, the extract I and the extract II are mixed to obtain a phellinus igniarius extract, and the phellinus igniarius extract is dried to obtain the phellinus igniarius extraction powder. Phellinus igniarius has the effects of promoting blood circulation, stopping bleeding, resolving fluid retention and stopping diarrhea.
Further, the method comprises a preparation step of the agaricus blazei extract powder, wherein the agaricus blazei is dried in the air and then ground into powder, the agaricus blazei is ground into powder and then placed in an environment with the temperature of minus 30 ℃ to be processed at low temperature for 24 hours, laser wall breaking processing is adopted after the low temperature processing for 24 hours, the agaricus blazei is placed in ethanol solution after the laser wall breaking processing and subjected to microwave oscillation to obtain ethanol solution containing the agaricus blazei extract, and then the ethanol solution containing the agaricus blazei extract is dried to obtain the agaricus blazei extract powder. Agaricus blazei Murill has high anticancer activity, and has effects of enhancing cellular immunity, tranquilizing mind, etc
Further, the method comprises a preparation step of kudzu root powder, which comprises the steps of firstly using a water gun to wash out silt impurities on the surface of kudzu root and in a crack, then cutting off rattan, tail hair and lateral roots by using a blade, then scraping off root bark, rinsing clean by using clear water, crushing kudzu root by using a crusher after the kudzu root is rinsed clean, crushing the kudzu root by using a crusher after the kudzu root is crushed, filtering to obtain kudzu root powder slurry after the kudzu root is crushed, sieving the kudzu root powder slurry by using 80-mesh, 100-mesh and 120-mesh screens in sequence to remove large-particle impurities, then using the kudzu root powder slurry to enter a sedimentation tank, stirring the kudzu root powder slurry in the sedimentation tank, adding 10% old slurry water into the kudzu root slurry during stirring, stirring for 10-60 minutes, standing for 10-12 hours to naturally separate and precipitate the impurities and the kudzu root powder, sucking out upper water after the kudzu root powder is completely precipitated, then adding clear water into wet kudzu root powder and stirring rapidly, dissolving radix Puerariae powder in water, filtering the slurry containing radix Puerariae powder with double-layer gauze, removing impurities at the bottom layer, allowing the slurry to enter the next-stage sedimentation tank, continuously precipitating and separating, shoveling the finally obtained wet radix Puerariae powder out of the sedimentation tank, putting into a clean cloth bag, hoisting the wet cloth bag with a rope, draining off clear water, breaking into small pieces, putting into a mesh screen paved with clean white cotton cloth, and drying with hot air in a fruit and vegetable dryer to obtain the final product radix Puerariae powder. The radix Puerariae powder and Chinese medicinal decoction can be made into tablet, and has effects of activating qi-flowing, resolving food stagnation, relieving swelling and relieving flatulence, and is suitable for treating hypochondriac pain, yellow and swollen face, abdominal lump, etc. after drinking.
After a human body ingests a large amount of alcohol, the traditional Chinese medicines of ginseng, flower of kudzuvine, kudzuvine root powder, pseudo-ginseng and acanthopanax root in the medicine can decompose the alcohol concentration and relieve the symptoms of dizziness, vomiting and the like caused by overhigh alcohol concentration.
The anti-hangover tablet is added with antrodia camphorata extract powder, phellinus linteus extract powder and agaricus blazei murill extract powder, wherein antrodia camphorata has the function of reducing alcoholic damage to liver, and meanwhile, the antrodia camphorata contains rich triterpenes and polysaccharides and has the curative effects of protecting liver, promoting hepatocyte regeneration and resisting liver cancer; phellinus igniarius has the effects of promoting blood circulation, stopping bleeding, resolving fluid retention and stopping diarrhea; the Brazilian mushroom has high anticancer activity, cell immunity enhancing and tranquilizing effects, and the tea polyphenols in the tablet can effectively reduce ethanol oxidation to acetaldehyde, remove toxicity of Z aldehyde, alkyl free radical, etc., and the generated strong antioxidation can excite anti-hangover factor in human liver, accelerate decomposition of alcohol in blood, and eliminate damage of lipid peroxide compound malondialdehyde to liver during alcohol decomposition.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. A liver-protecting sobering-up medicine is characterized in that: the feed is prepared from the following raw materials in parts by weight: 5 parts of ginseng, 30 parts of pueraria flower, 10 parts of pseudo-ginseng, 10 parts of acanthopanax, 100 parts of pueraria powder, 2 parts of antrodia camphorata extract powder, 40 parts of phellinus linteus extract powder, 50 parts of agaricus blazei extract powder, 10 parts of grape tea polyphenol, 100 parts of starch and 70 parts of edible gum.
2. The drug for protecting liver and sobering up as claimed in claim 1, wherein: the components of the grape tea polyphenol are tea polyphenol, grape seed extract and vitamin C.
3. The drug for protecting liver and sobering up as claimed in claim 1, wherein: the radix Puerariae powder is prepared from radix Puerariae.
4. A liver-protecting and sobering medicine according to claim 1, characterized in that: the Ginseng radix is selected from rhizoma Gymnadeniae or rhizoma Gymnadeniae.
5. The liver-protecting and sobering medicine according to claim 1, characterized in that: the acanthopanax senticosus is selected from a tender bud which just grows.
6. A method for producing a liver-protecting and sobering-up drug according to any one of claims 1-5, wherein the liver-protecting and sobering-up drug comprises the following steps: the production steps are as follows:
the method comprises the following steps: putting 5 parts of ginseng, 30 parts of pueraria flower, 10 parts of pseudo-ginseng and 10 parts of acanthopanax root into a decocting machine, decocting for 1 hour with strong fire, decocting for 2 hours with slow fire, and filtering to obtain a traditional Chinese medicine decoction after the decoction is finished;
step two: uniformly mixing 100 parts of radix puerariae powder, 2 parts of antrodia camphorata extraction powder, 40 parts of phellinus linteus extraction powder, 50 parts of agaricus blazei extraction powder and 100 parts of starch, sequentially adding 10 parts of grape tea polyphenol and the traditional Chinese medicine decoction prepared in the first step in the mixing process, then adding 70 parts of edible gum as an adhesive, mixing to obtain a granulation raw material, and finally placing the granulation raw material in a granulator to obtain the liver-protecting sobering-up tablet.
7. The liver-protecting and sobering medicine according to claim 6, characterized in that: the method comprises the following steps of cleaning and drying the surface of the antrodia camphorata, crushing the antrodia camphorata to be less than 18 microns by adopting an ultramicro crushing technology to obtain antrodia camphorata bacterial powder, treating the antrodia camphorata bacterial powder at the low temperature of minus 30 ℃ for 24 hours, carrying out the low-temperature treatment for 24 hours, carrying out laser wall breaking treatment, carrying out the laser wall breaking treatment on the antrodia camphorata bacterial powder, placing the antrodia camphorata bacterial powder in an ethanol solution, carrying out microwave oscillation to obtain the ethanol solution containing the antrodia camphorata extract, and drying the ethanol solution containing the antrodia camphorata extract to obtain the antrodia camphorata extract powder.
8. The liver-protecting and sobering medicine according to claim 6, characterized in that: the method also comprises a preparation step of the phellinus igniarius extraction powder, wherein the surface of the phellinus igniarius is cleaned and then crushed, the crushed phellinus igniarius is soaked in an ethanol solution with the concentration of 80%, a supernatant is taken to obtain an extract I, a residual residue is filtered, a residual supernatant is taken as an extract II, the extract I and the extract II are mixed to obtain a phellinus igniarius extract, and the phellinus igniarius extraction powder is obtained after the phellinus igniarius extract is dried.
9. The liver-protecting and sobering medicine according to claim 6, characterized in that: the preparation method comprises the following steps of drying the agaricus blazei murill, grinding the agaricus blazei murill into powder, placing the powder in an environment with the temperature of minus 30 ℃ for low-temperature treatment for 24 hours, performing laser wall breaking treatment after the low-temperature treatment for 24 hours, placing the agaricus blazei murill in an ethanol solution for microwave oscillation to obtain the ethanol solution containing the agaricus blazei murill extract after the laser wall breaking treatment, and drying the ethanol solution containing the agaricus blazei murill extract to obtain the agaricus blazei murill extract powder.
10. The liver-protecting and sobering medicine according to claim 6, characterized in that: the preparation method comprises the steps of washing silt impurities on the surface and in a crack of the kudzuvine root by using a water gun, cutting off rattan, tail hair and side roots by using a blade, scraping off root bark, rinsing the root bark by using clear water, crushing the kudzuvine root by using a crusher after the kudzuvine root is rinsed, filtering the crushed kudzuvine root to obtain kudzuvine root starch slurry, sieving the kudzuvine root starch slurry by using 80-mesh, 100-mesh and 120-mesh screens in sequence to remove large-particle impurities, feeding the kudzuvine root starch slurry into a sedimentation tank, stirring the kudzuvine root starch slurry in the sedimentation tank, adding 10% old slurry into the kudzuvine root starch slurry during stirring, stirring for 10-60 minutes, standing for 10-12 hours to naturally separate and precipitate the impurities and the kudzuvine root powder, sucking out the water on the upper layer after the kudzuvine root powder is completely precipitated, adding the clear water into the wet kudzuvine root powder, rapidly stirring to dissolve the kudzuvine root powder in the water, and then filtering the slurry containing the kudzu root powder by double-layer gauze, removing impurities at the bottom layer, allowing the slurry to enter a next-stage sedimentation tank, continuously precipitating and separating, shoveling the finally obtained wet kudzu root powder out of the sedimentation tank, putting the wet kudzu root powder into a clean cloth bag, hoisting the wet kudzu root powder by a rope to a ventilated part, draining clear water, breaking the wet kudzu root powder into small pieces, putting the small pieces into a mesh screen paved with clean white cotton cloth, and drying the small pieces in a fruit and vegetable dryer by hot air to obtain the finished kudzu root powder.
CN202210395044.3A 2022-04-15 2022-04-15 Liver-protecting sobering-up medicine and its production method Pending CN114642689A (en)

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Application publication date: 20220621