CN1146337A - Anti-parasite oral liquid for animal containing avermectin or ivermectin - Google Patents
Anti-parasite oral liquid for animal containing avermectin or ivermectin Download PDFInfo
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- CN1146337A CN1146337A CN 96109197 CN96109197A CN1146337A CN 1146337 A CN1146337 A CN 1146337A CN 96109197 CN96109197 CN 96109197 CN 96109197 A CN96109197 A CN 96109197A CN 1146337 A CN1146337 A CN 1146337A
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- liquid
- oral liquid
- ivermectin
- avilamycin
- animal
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Abstract
The antiparasitic oral liquor for animals consists of the following components, acetone 2-15%, antiseptic 0.5-1%, surfactant 2-15%, water 70-85% (volume percentage), in the above mentioned total liquor, 0.02-0.2g of crystal of avermectin or ivermectin is added to each 100 ml of the total liquid. In the oral liquor, the 1,2-propylene glycol, ethyl alcohol and imidazole class medicine can also be added. Said oral liquor features simple for technological operation, low cost, convenient for applying, compared with the mycelium preparation, said oral liquor is higher in safety, still more beneficial to the absorption of the animals and more better parasiticidal result.
Description
The present invention relates to anti-parasite oral liquid for animal, particularly a kind of anti-parasite oral liquid for animal that contains avilamycin or Ivermectin HCL.
Found avilamycin (Avermectin) and Ivermectin HCL (Ivermectin) in 76 years, avilamycin is the metabolite of streptomycete (Streptomyces Vrmitilis), and Ivermectin HCL is the reduzate of avilamycin, this material has wide spectrum, anti-insect activity efficiently, the eighties, U.S. Merch company succeeded in developing insecticide and antiparasitic with these two kinds of materials, and put on market.
The mixture that avilamycin (Avermectin) is made up of eight quite similar homologues of structure.That is: Avermectin A
1a, A
1b, A
2a, B
1a, B
1b, B
2a, B
2bB wherein
1aComponent is the component that insecticidal activity is the highest, insecticidal spectrum is the widest.But because of B1a and B1b are difficult to separate effectively in suitability for industrialized production, so that be widely used now is B
1aAnd B
1bRespectively account for certain proportion (B
1aAccount for more than 80% B
1bAccount for below 20%) mixture B
1, and B
1Hydrogenating reduction product Ivermectin HCL.B
1And B
1Hydrogenating reduction product (IVM) be widely used in the prophylactic treatment of the parasitic disease of animal in plant protection in the agricultural production and the animal husbandry.Nematicide all has the extremely strong effect of killing in animal body outer demodicid mite, Ticks, fly, maggot and the body to extensively resulting from for it.
The most common dosage form is to use B at present
1With the injection of IVM preparation, tablet and powder that also useful mycelium directly prepares, but the use inconvenience that said products has, the cost that has is higher.
The structural formula of relevant avilamycin and eight quite similar homologues compositions of structure are asked for an interview Fig. 1 and table 1.
The object of the invention provides a kind of anti-parasite oral liquid for animal, and this dosage form has to be used very conveniently, and cost is low, good effect, advantage such as insecticidal spectrum is extensive.
For achieving the above object, the present invention by the following technical solutions: a kind of anti-parasite oral liquid for animal comprises following component: acetone 2～15%; Antiseptic 0.5～1%; Surfactant 2～15%; Water 70～85%, (volume percentage); In the aforesaid liquid total amount, by being furnished with 0.02～0.2g avilamycin B in every 100ml liquid
1Or Ivermectin HCL B
1The crystallization product, B in the crystallization product
1Content＞90%.Another kind of anti-parasite oral liquid for animal comprises following component: acetone 2～15%; 1.2-propylene glycol 60～80%; Ethanol 2～15%; Surfactant 4～15%; Antiseptic 0.5～1% (volume percentage) in the aforesaid liquid total amount, is furnished with 0.2～5g avilamycin B by 100ml liquid
1Or Ivermectin HCL B
1The crystallization product, B in the crystallization product
1Content＞90%.
With AVM B
1Or IVMB
1With contain that imidazoles is composite makes compound oral liquid formulation, can increase insecticidal spectrum.Can kill parasites such as nematicide, cestode, trematodiasis, external Cicadae, louse, demodicid mite, fly, maggot in the body, cost of drugs can reduce.
The composition that contains the compound oral liquid formulation that imidazole class medicine is re-dubbed is: acetone 2～15%; 1.2-propylene glycol 60～80%; Ethanol 2～15%; Surfactant 4～15% (volume percentage) in the aforesaid liquid total amount, is furnished with 0.2～5g avilamycin B by 100ml liquid
1Or Ivermectin HCL B
1The crystallization product, B in the crystallization product
1Content＞90%.Is furnished with imidazole class medicine 6～15% in every 100ml liquid.
The avilamycin B that is adopted in above-mentioned several anti-parasite oral liquid for animal
1Crystallization product production technology is: AVM oily article add ethanol and carry out the AVM crystallization purifying, with AVM grease: the mixed of ethanol (95%)=1.2～4 (volume ratio), through 24～72 hours, filter and promptly get AVMB
1Crystallization product, these crystallization product detect AVMB through vacuum drying (90 ℃)
1Component, its content reaches more than 90%.
The preparation method of avilamycin oily mixture (hereinafter to be referred as AVM grease): produce bacterial strain and sent out alcohol → filtration → mycelium through 10 days.Mycelium is decoloured → concentrates → AVM grease with acetone or ethyl acetate lixiviate → filtration (or centrifugal) → lixiviating solution.The overwhelming majority can be paid the effect composition through technologies such as decolourings and remove, this mixture consist of A
13～10%, A
28～15%, B
16～15%, B
23～10%, 14～8 carbon fatty acids 35～40%, water 10～15%.
In above-mentioned several oral liquid prescriptions, the surfactant that is adopted can be that nonionic surfactant also can be an anionic, cationic surface active agent, and surfactant has tween 80, TX-100 etc., antiseptic can adopt benzyl alcohol etc.
The invention will be further described below in conjunction with embodiment:
Embodiment 1:
Take by weighing the AVMB of 110g purity more than 90%
1(or IVM) places material-compound tank, adds 5 liters of acetone, makes AVMB
1(or IVM) dissolves fully, adds 5 liters of surfactant TX-100 again, and antiseptic benzyl alcohol 500ml mixing adds 90 premium on currency mixings.Aseptic filtration, quality testing, packing, vanning, warehouse-in.
Consumption, usage: when killing cattle, sheep endoparasite and ectoparasite, the per kilogram of body weight consumption is 0.2ml, with the bottleneck connection tube of dress mouthful newspaper liquid with gavage device continuously and connect, measure on demand and be transferred to assigned scale and can gavage continuously.
Embodiment 2
1g AVMB
1(or IVM) with adding 1.2-propylene glycol 75ml after the 10ml acetone solution, adds ethanol 10ml, adds benzyl alcohol 1ml, adds tween 80 4ml, aseptic filtration, bottle, seal, quality inspection, warehouse-in.
Embodiment 3
1g AVMB
1(or IVM) with adding 1.2-propylene glycol 69ml after the 10ml acetone solution, adds ethanol 10ml, adds benzyl alcohol 1ml, adds tween 80 10ml, aseptic filtration, bottle, seal, quality inspection, warehouse-in.
Consumption, usage: in 1: 9 ratio thin up (the 1ml oral liquid adds 9ml water), kill cattle, sheep body ecto-and endoparasites during use, every 50kg body weight gavages the 10ml water diluent, the available device that gavages continuously gavages, kill the pig parasite, per 50 kg body weight clothes 15ml can mix in feedstuff and feed.
Embodiment 4
Get 0.2～0.4 gram AVMB
1(or IVM) gets solution A with 10 milliliters of acetone solutions, gets 10 gram rosickyite benzene imidazoles and dissolves with the 5ml glacial acetic acid, and it is 5～6 that the reuse organic amine is transferred PH, promptly gets solution B; A, B are mixed the back add 10ml nonionic surfactant tween 80 and 1.2-propylene glycol 70ml, ethanol 10ml and benzyl alcohol 1ml mixing, aseptic filtration, quality testing, packing then, quality inspection, warehouse-in.
Consumption and usage are with embodiment 2.
Embodiment 5
The consumption that changes non-ionic surfactant Tween-80 is 5ml, and 1.2 propylene glycol consumptions are 75ml, and all the other consumptions are equal to embodiment 4.
Advantage of the present invention:
Compare with tablet, pulvis, parenteral solution, oral liquid type technology is easy and simple to handle, and cost is low, joins Use to gavage device, very convenient; Compare with the mycelium preparation, have higher to animal safety, Safety coefficient is greater than 50 times of medicine regulation, in the oral liquid because the assistant agent effect, make animal to AVM ( Or VIM) absorb better, repelling and killing efficacy is better than other oral formulation, for example solid oral dosage forms.
Claims (5)
1, a kind of anti-parasite oral liquid that contains avilamycin or Ivermectin HCL for animals is characterized in that it comprises following component: acetone 2～15%; Antiseptic 0.5～1%; Surfactant 2～15%; Water 70～85%, (volume percentage); In the aforesaid liquid total amount, by being furnished with 0.02～0.2g avilamycin B in every 100ml liquid
1Or Ivermectin HCL B
1The crystallization product, B in the crystallization product
1Content＞90%.
2, a kind of anti-parasite oral liquid that contains avilamycin or Ivermectin HCL for animals is characterized in that it comprises following component: acetone 2～15%; 1.2-propylene glycol 60～80%; Ethanol 2～15%; Surfactant 4～15%; Antiseptic 0.5～1% (volume percentage) in the aforesaid liquid total amount, is furnished with 0.2～5g avilamycin B by 100ml liquid
1Or Ivermectin HCL B
1The crystallization product, B in the crystallization product
1Content＞90%.
3, by the described anti-parasite oral liquid for animal of claim 2, it is characterized in that described dosage of surfactant accounts for total amount of liquid 10%.
4, by the described anti-parasite oral liquid for animal of claim 2, it is characterized in that in the described total amount of liquid that every 100ml liquid also is furnished with imidazoles 6～15g.
5, by the described anti-parasite oral liquid for animal of claim 4, it is characterized in that described dosage of surfactant accounts for 10% of total amount of liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96109197 CN1146337A (en) | 1996-08-19 | 1996-08-19 | Anti-parasite oral liquid for animal containing avermectin or ivermectin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96109197 CN1146337A (en) | 1996-08-19 | 1996-08-19 | Anti-parasite oral liquid for animal containing avermectin or ivermectin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1146337A true CN1146337A (en) | 1997-04-02 |
Family
ID=5120296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96109197 Pending CN1146337A (en) | 1996-08-19 | 1996-08-19 | Anti-parasite oral liquid for animal containing avermectin or ivermectin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1146337A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069033C (en) * | 1998-11-13 | 2001-08-01 | 王玉万 | Anti-parasite oral spray containing evericin and ivermectin for sheep |
| CN1114411C (en) * | 1998-08-07 | 2003-07-16 | 武汉第四制药厂 | Compound prothiphenyl imidazole emulsion for repelling and curing animal endoparasites and ectoparasite, and method for preparing same |
| CN102525916A (en) * | 2011-12-29 | 2012-07-04 | 郑国祥 | Ivermectin colloidal solution preparation and preparation method thereof |
-
1996
- 1996-08-19 CN CN 96109197 patent/CN1146337A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114411C (en) * | 1998-08-07 | 2003-07-16 | 武汉第四制药厂 | Compound prothiphenyl imidazole emulsion for repelling and curing animal endoparasites and ectoparasite, and method for preparing same |
| CN1069033C (en) * | 1998-11-13 | 2001-08-01 | 王玉万 | Anti-parasite oral spray containing evericin and ivermectin for sheep |
| CN102525916A (en) * | 2011-12-29 | 2012-07-04 | 郑国祥 | Ivermectin colloidal solution preparation and preparation method thereof |
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| PB01 | Publication |