CN102525916A - Ivermectin colloidal solution preparation and preparation method thereof - Google Patents
Ivermectin colloidal solution preparation and preparation method thereof Download PDFInfo
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- CN102525916A CN102525916A CN2011104489579A CN201110448957A CN102525916A CN 102525916 A CN102525916 A CN 102525916A CN 2011104489579 A CN2011104489579 A CN 2011104489579A CN 201110448957 A CN201110448957 A CN 201110448957A CN 102525916 A CN102525916 A CN 102525916A
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Abstract
The invention relates to an ivermectin colloidal solution preparation and a preparation method thereof. The ivermectin colloidal solution preparation respectively comprises the following ingredients in parts by weight: 0.05-5 parts of ivermectin, 1-50 parts of solvent, 1-30 parts of stabilizer (emulsifier) and 0.01-20 parts of thickening agent; and the preparation method of the ivermectin colloidal solution preparation comprises the following steps of: (1) mixing the ivermectin with the solvent, and heating to the temperature of 40 DEG C, so as to fully dissolve the ivermectin for standby; (2) mixing the stabilizer (emulsifier) with the thickening agent according to the ratio of the parts by weight, and evenly stirring for standby; and (3) adding the mixture obtained in the step (2) into the mixture obtained in the step (1), evenly stirring, and adding water to a full dose to obtain an ivermectin colloidal solution. The ivermectin colloidal solution preparation has the advantages of little toxicity, low preparation cost and simple preparation process.
Description
Technical field
The invention belongs to the veterinary drug preparation technical field, what be specifically related to is a kind of ivermectin colloidal solution preparation and preparation method thereof.
Background technology
Ivermectin (Ivermectin) is the derivant of avilamycin, and that industry is generally acknowledged is efficient, low toxicity, broad-spectrum antiparasitic thing.Since the listing eighties in last century, be used widely.Because this medicine is insoluble in water, the listing initial stage has only injection (full organic solvent), powder, pre-mixing agent.Because the crude drug price is high, dosage form is single, makes the popularity of its application receive very big restriction.Along with the continuous progress of preparation technique, from the beginning of this century till now, the dosage form of this medicine research and development have obtained tremendous development.Like ivermectin transdermal agent, long-acting sustained-release agent, microemulsion etc.But be insoluble in the reason of water in the above-mentioned dosage form owing to ivermectin; The consumption of organic solvent is strengthened; Causing that the preparation cost is high, toxicity is relatively large, though microemulsion formulation can be scattered in ivermectin in the water, also is owing to used a large amount of surfactants just can reach its final purpose.
Colloid solution pharmaceutical preparation is that medicine is scattered in the liquid with microgranule (1-100nm) form, form stable colloidal solution and must satisfy two conditions simultaneously:
(1) atomic particle diameter is in the 1-100nm scope.
(2) micropartical keeps dispersity in liquid medium under the condition that has stabilizing agent to exist, and not coalescence.Because the micropartical in the colloidal solution has Blang (Brown) motion, belongs to the dynamic stabilization system, so colloidal solution is a clear liquid, micropartical can keep not precipitating for a long time.
Summary of the invention
In view of some deficiency of prior art, the object of the invention aims to provide that a kind of consumption of organic solvent is few, efficient, cheap, the ivermectin colloidal solution preparation of long-acting slow-release.
The ivermectin colloidal solution is that this medicinal solvent is changed method, and high degree of dispersion is in aqueous solution.Said solvent replacement method is: ivermectin is dissolved in earlier (good solvent) makes it to become true solution in the organic solvent that stabilizing agent exists, its adding can not be dissolved in the aqueous solution of ivermectin (poor solvent) again.Owing to, make the ivermectin that is dissolved in the good solvent with a kind of material characteristic that dissolubility differs greatly in different solvents, after adding poor solvent,, its dissolubility separates out with the form of colloidal particles because of descending, form colloidal solution.
In view of the These characteristics of ivermectin colloidal solution, do not find ivermectin is prepared at present the open report of colloidal solution as yet.
The technical scheme that adopts is:
A kind of ivermectin colloidal solution preparation; It is characterized in that by ivermectin, solvent, stabilizing agent (emulsifying agent), thickening agent formulatedly, it is respectively by weight: ivermectin: 0.05-5 part, solvent: 1-50 part; Stabilizing agent (emulsifying agent): 1-30 part, thickening agent: 0.01-20 part.
Said solvent is ethanol, propanol, isopropyl alcohol, butanols, sec-butyl alcohol, the tert-butyl alcohol, benzyl alcohol, β phenethanol, 1; A kind of or the above-mentioned multiple mixture that constitutes with arbitrary proportion of 2 propylene glycol, 1,3 propylene glycol, glycerin, Polyethylene Glycol-200, Polyethylene Glycol-300, Polyethylene Glycol-400, dimethyl formamide, dimethyl acetylamide, N-methyl-ketopyrrolidine, alpha-pyrrolidone, dimethyl sulfoxide, glycerin methylal, ethyl acetate.
Said stabilizing agent (emulsifying agent) is a sodium lauryl sulphate; Dodecyl sodium sulfate; Sodium hexadecyl sulfate; Sodium stearyl sulfate; Sodium alkyl benzene sulfonate; Glycerol monostearate sodium; Glyceryl monolaurate; Polyglycereol stearic acid esters; The polyglycerol acrylate class; Polyglycereol lauric acid esters; Sucrose monostearate; Sucrose palmitic acid ester; Sucrose monolaurate; Sucrose list myristate; The sucrose monooleate acid esters; Arlacel-20; Arlacel-40; Arlacel-60; Arlacel-65; Arlacel-80; Arlacel-85; Tween 20; Tween-40; Tween-60; Tween-65; Tween 80; Tween 85; Myrij-45; Myrij-49; Myrij-51; Myrij-52; Myrij-53; Myrij-59; Brij-30; Brij-35; AEO
2, AEO
3, AEO
4, AEO
7, AEO
8, AEO
9, A
10～18EO
9Paregal O-9; Paregal O-10; Paregal O-20; Paregal O; Peregal os-15; Paregal O-25; Paregal O-35 peregal A-20; XBP-2000; Polyoxyethylene ester; Myrj 45; Polyoxyethylene laurate; Isopropyl myristate; Polyoxyethylene castor oil condensation substance EL-10; EL-15; EL-20; EL-30; EL-40; EL-80; EL-90; OPEO; NPE; Polyethers L31; Polyethers L35; Polyethers L38; Polyethers L42; Polyethers L43; Polyethers L44; Polyethers L61; Polyethers L62; Polyethers L63; Polyethers L64; Polyethers L68; Polyethers L72; Polyethers L81; Polyethers L92; Polyethers P65; Polyethers P75; Polyethers P77; Polyethers P84; Polyethers P85; Polyethers F87; Polyethers F88; Polyethers P94; Polyethers P103; Polyethers P104; Polyethers P105; A kind of or the above-mentioned multiple mixture that constitutes with arbitrary proportion of polyethers P108.
Said thickening agent is a kind of or above-mentioned multiple mixture that constitutes with arbitrary proportion of glycerin, dextran-20, dextran-40, dextran-70, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose, sodium alginate, carboxymethylcellulose calcium, hydroxyethyl-cellulose, propylene glycol sodium alginate, carboxymethyl starch sodium, sodium starch phosphate, sodium tripolyphosphate, polyvinylpyrrolidone (PVP), carbomer.
A kind of method for preparing of ivermectin colloidal solution is characterized in that comprising following processing step:
1. by above-mentioned weight portion proportioning,, be heated to 40 ℃, ivermectin is all dissolved ivermectin and solvent, subsequent use.
2. by above-mentioned weight portion proportioning, stabilizing agent (emulsifying agent) is mixed with thickening agent, stir, subsequent use.
3. in adding 1 with 2, stir, add water to full dose, both got the ivermectin colloidal solution.
Usefulness of the present invention is: since ivermectin be with nanoscale micelle microparticulate in water, but the holdup time of prolong drug in circulating in vivo reach the purpose of slow releasing pharmaceutical and target administration; The present invention is with showing activating agent and alcohols solvent composition mixed micelle; Increased the dissolubility of ivermectin in water greatly; Effectively reduced the consumption of organic solvent in preparation, make the toxicity of ivermectin colloidal solution little, cheap for manufacturing cost, preparation technology is simple.
The specific embodiment
Embodiment 1:
A kind of ivermectin colloidal solution, its prescription is respectively by weight: component drugs: 0.04 part of ivermectin, solvent: 3 parts of 1,2 propylene glycol, 5 parts of stabilizing agent (emulsifying agent): Np-10, thickening agent: 0.2 part of carbomer.
A kind of method for preparing of ivermectin colloidal solution, its concrete technical process is following:
1. with 0.04g ivermectin and 3g 1,2 mixed with propylene glycol, be heated to 40 ℃, ivermectin is all dissolved, add 5gNp-10, stir, subsequent use.
2. 1 adding is contained 0.2g carbomer aqueous solution to 100ml, both clear and bright ivermectin colloid solution.
Embodiment 2:
A kind of ivermectin colloidal solution, its prescription is respectively by weight: component drugs: 0.08 part of ivermectin, solvent: 7.5 parts of ethanol, stabilizing agent (emulsifying agent): peregal A-20 5 part, thickening agent: 5 parts of glycerin.
A kind of method for preparing of ivermectin colloidal solution, its concrete technical process is following:
1. the 0.08g ivermectin is mixed with 7.5g ethanol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. the peregal A-20 behind the 5g hot melt is mixed with the 5g glycerin, stir, subsequent use.
3. in adding 1 with 2, stir, add water to 100ml, both clear and bright ivermectin colloid solution.
Embodiment 3:
A kind of ivermectin colloidal solution, its prescription is respectively by weight: component drugs: 0.2 part of ivermectin, solvent: 5 parts of benzyl alcohol, 6 parts of stabilizing agent (emulsifying agent): EL-20,5 parts of Np-10, thickening agent: 0.2 part of sodium carboxymethyl cellulose.
A kind of method for preparing of ivermectin colloidal solution, its concrete technical process is following:
1. the 0.2g ivermectin is mixed with the 5g benzyl alcohol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. 6gEL-20,5gNp-10 are mixed, stir, subsequent use.
3. in adding 1 with 2, stir, add contain the 0.2g sodium carboxymethyl cellulose aqueous solution to 100ml, both clear and bright ivermectin colloid solution.
Embodiment 4:
A kind of ivermectin colloidal solution; Its prescription is respectively by weight: component drugs: 0.5 part of ivermectin; Solvent: 5 parts of isopropyl alcohols, 3 parts of stabilizing agent (emulsifying agent): EL-20, paregal O-9 6 part, thickening agent: 1 part of polyvinylpyrrolidone (PVP).
A kind of method for preparing of ivermectin colloidal solution, its concrete technical process is following:
1. the 0.5g ivermectin is mixed with the 5g isopropyl alcohol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. 3gEL-20,6g paregal O-9 are mixed, stir, subsequent use.
3. in adding 1 with 2, stir, add contain 1g polyvinylpyrrolidone (PVP) aqueous solution to 100ml, both clear and bright ivermectin colloid solution.
Embodiment 5:
A kind of ivermectin colloid solution, its prescription is respectively by weight: component drugs: 1 part of ivermectin, solvent: 10 parts of the tert-butyl alcohols, 4 parts of stabilizing agent (emulsifying agent): EL-40,7 parts of polyethers F87, thickening agent: 2 parts of polyvinylpyrrolidones (PVP).
A kind of method for preparing of ivermectin colloid solution, its concrete technical process is following:
1. the 1g ivermectin is mixed with the 10g tert-butyl alcohol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. the polyethers F87 with 4gEL-40,7g hot melt mixes, and stirs, and is subsequent use.
3. in adding 1 with 2, stir, add contain 2g polyvinylpyrrolidone (PVP) aqueous solution to 100ml, both clear and bright ivermectin colloid solution.
Embodiment 6:
A kind of ivermectin colloid solution; Its prescription is respectively by weight: component drugs: 2 parts of ivermectins, solvent: 5 parts of glycerin methylals, 8 parts of 1,2 propylene glycol; 5 parts of stabilizing agent (emulsifying agent): EL-40,5 parts of polyethers L68, thickening agent: 2 parts of polyvinylpyrrolidones (PVP).
A kind of method for preparing of ivermectin colloid solution, its concrete technical process is following:
1. with 2g ivermectin and 5g glycerin methylal, 8g 1,2 mixed with propylene glycol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. the polyethers L68 with 5gEL-40,5g hot melt mixes, and stirs, and is subsequent use.
3. in adding 1 with 2, stir, add contain 2g polyvinylpyrrolidone (PVP) aqueous solution to 100ml, both clear and bright ivermectin colloid injection.
Embodiment 7:
A kind of ivermectin colloidal solution; Its prescription is respectively by weight: component drugs: 3 parts of ivermectins; Solvent: 8 parts of dimethyl acetylamide, 5 parts of ethanol, 8 parts of stabilizing agent (emulsifying agent): Np-10,7 parts of polyethers L68, thickening agent: 3 parts of polyvinylpyrrolidones (PVP).
A kind of method for preparing of ivermectin colloidal solution, its concrete technical process is following:
1. the 3g ivermectin is mixed with 8g dimethyl acetylamide, 5g ethanol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. 8gNp-10,7g polyethers L68 are mixed, stir, subsequent use.
3. in adding 1 with 2, stir, add contain 3g polyvinylpyrrolidone (PVP) aqueous solution to 100ml, both clear and bright ivermectin colloid solution.
Embodiment 8:
A kind of ivermectin colloid solution; Its prescription is respectively by weight: component drugs: 4 parts of ivermectins; Solvent: 5 parts of N-methyl-ketopyrrolidines, 5 parts of ethanol, stabilizing agent (emulsifying agent): 5 parts of tween 80s, 8 parts of peregal A-20, thickening agent: 0.5 part of carbomer.
A kind of method for preparing of ivermectin colloid injection, its concrete technical process is following:
1. the 4g ivermectin is mixed with 5g N-methyl-ketopyrrolidine, 5g ethanol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. the peregal A-20 with 5g tween 80,8g hot melt mixes, and stirs, and is subsequent use.
3. in adding 1 with 2, stir, add 0.5g carbomer aqueous solution to 100ml, after filtration, fill, the sterilization both clear and bright ivermectin sol solution.
Embodiment 9:
A kind of ivermectin colloid solution; Its prescription is respectively by weight: component drugs: 5 parts of ivermectins; Solvent: 8 parts of alpha-pyrrolidones, 10 parts of ethanol, 8 parts of stabilizing agent (emulsifying agent): EL-20,10 parts of paregal Os, thickening agent: 0.2 part of propylene glycol sodium alginate.
A kind of ivermectin colloid is annotated the method for preparing of solution, and its concrete technical process is following:
1. the 5g ivermectin is mixed with 8g alpha-pyrrolidone, 10g ethanol, be heated to 40 ℃, ivermectin is all dissolved, subsequent use.
2. the paregal O with 8g EL-20,10g hot melt mixes, and stirs, and is subsequent use.
3. in adding 1 with 2, stir, add contain 0.2g propylene glycol sodium alginate aqueous solution to 100ml, after filtration, fill, the sterilization both clear and bright ivermectin colloid solution.
Claims (5)
1. ivermectin colloidal solution preparation; It is characterized in that by ivermectin, solvent, stabilizing agent (emulsifying agent), thickening agent formulated; It is respectively by weight: ivermectin: 0.05-5 part; Solvent: 1-50 part, stabilizing agent (emulsifying agent): 1-30 part, thickening agent: 0.01-20 part.
2. a kind of ivermectin colloidal solution preparation according to claim 1; It is characterized in that: described solvent is ethanol, propanol, isopropyl alcohol, butanols, sec-butyl alcohol, the tert-butyl alcohol, benzyl alcohol, β phenethanol, 1; A kind of or the above-mentioned multiple mixture that constitutes with arbitrary proportion of 2 propylene glycol, 1,3 propylene glycol, glycerin, Polyethylene Glycol-200, Polyethylene Glycol-300, Polyethylene Glycol-400, dimethyl formamide, dimethyl acetylamide, N-methyl-ketopyrrolidine, alpha-pyrrolidone, dimethyl sulfoxide, glycerin methylal, ethyl acetate.
3. a kind of ivermectin colloidal solution preparation according to claim 1 is characterized in that: described stabilizing agent is sodium lauryl sulphate, dodecyl sodium sulfate, sodium hexadecyl sulfate, sodium stearyl sulfate, sodium alkyl benzene sulfonate, glycerol monostearate sodium, glyceryl monolaurate, polyglycereol stearic acid esters, polyglycerol acrylate class, polyglycereol lauric acid esters, sucrose monostearate, sucrose palmitic acid ester, sucrose monolaurate, sucrose list myristate, sucrose monooleate acid esters, Arlacel-20, Arlacel-40, Arlacel-60, Arlacel-65, Arlacel-80, Arlacel-85, tween 20, Tween-40, Tween-60, Tween-65, tween 80, tween 85, Myrij-45, Myrij-49, Myrij-51, Myrij-52, Myrij-53, Myrij-59, Brij-30, Brij-35, AEO
2, AEO
3, AEO
4, AEO
7, AEO
8, AEO
9, A
10～18EO
9Paregal O-9; Paregal O-10; Paregal O-20; Paregal O; Peregal os-15; Paregal O-25; Paregal O-35 peregal A-20; XBP-2000; Polyoxyethylene ester; Myrj 45; Polyoxyethylene laurate; Isopropyl myristate; Polyoxyethylene castor oil condensation substance EL-10; EL-15; EL-20; EL-30; EL-40; EL-80; EL-90; OPEO; NPE; Polyethers L31; Polyethers L35; Polyethers L38; Polyethers L42; Polyethers L43; Polyethers L44; Polyethers L61; Polyethers L62; Polyethers L63; Polyethers L64; Polyethers L68; Polyethers L72; Polyethers L81; Polyethers L92; Polyethers P65; Polyethers P75; Polyethers P77; Polyethers P84; Polyethers P85; Polyethers F87; Polyethers F88; Polyethers P94; Polyethers P103; Polyethers P104; Polyethers P105; A kind of or the above-mentioned multiple mixture that constitutes with arbitrary proportion of polyethers P108.
4. a kind of ivermectin colloidal solution preparation according to claim 1 is characterized in that: described thickening agent is a kind of or above-mentioned multiple mixture that constitutes with arbitrary proportion of glycerin, dextran-20, dextran-40, dextran-70, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose, sodium alginate, carboxymethylcellulose calcium, hydroxyethyl-cellulose, propylene glycol sodium alginate, carboxymethyl starch sodium, sodium starch phosphate, sodium tripolyphosphate, polyvinylpyrrolidone, carbomer.
5. the method for preparing of an ivermectin colloidal solution is characterized in that comprising following processing step:
(1). by above-mentioned weight portion proportioning,, be heated to 40 ℃, ivermectin is all dissolved ivermectin and solvent, subsequent use;
By above-mentioned weight portion proportioning, stabilizing agent (emulsifying agent) is mixed with thickening agent, stir, subsequent use;
3. in adding 1 with 2, stir, add water to full dose, both got the ivermectin colloidal solution.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104489579A CN102525916A (en) | 2011-12-29 | 2011-12-29 | Ivermectin colloidal solution preparation and preparation method thereof |
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| CN2011104489579A CN102525916A (en) | 2011-12-29 | 2011-12-29 | Ivermectin colloidal solution preparation and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039441A (en) * | 2013-01-24 | 2013-04-17 | 凤台县精华助剂有限公司 | Water emulsion type l40 surface active agent |
| CN103655466A (en) * | 2013-11-18 | 2014-03-26 | 河南迪冉生物科技有限公司 | Ivermectin injection and preparation method thereof |
| CN113242747A (en) * | 2018-10-12 | 2021-08-10 | 好利安科技有限公司 | Macrolide formulations, method for preparing them and use of said formulations in the treatment of diseases secondary to ocular parasites |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4389397A (en) * | 1980-08-04 | 1983-06-21 | Merck & Co., Inc. | Solubilization of ivermectin in water |
| CN1146337A (en) * | 1996-08-19 | 1997-04-02 | 北京农业大学新技术开发总公司 | Anti-parasite oral liquid for animal containing avermectin or ivermectin |
| CN1241404A (en) * | 1999-07-16 | 2000-01-19 | 王玉万 | Avermectin-or ivermectin-containing slow releasing injecta |
-
2011
- 2011-12-29 CN CN2011104489579A patent/CN102525916A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4389397A (en) * | 1980-08-04 | 1983-06-21 | Merck & Co., Inc. | Solubilization of ivermectin in water |
| CN1146337A (en) * | 1996-08-19 | 1997-04-02 | 北京农业大学新技术开发总公司 | Anti-parasite oral liquid for animal containing avermectin or ivermectin |
| CN1241404A (en) * | 1999-07-16 | 2000-01-19 | 王玉万 | Avermectin-or ivermectin-containing slow releasing injecta |
Non-Patent Citations (1)
| Title |
|---|
| 扈洪波等: "Ivermectin的制剂研究", 《中国兽药杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039441A (en) * | 2013-01-24 | 2013-04-17 | 凤台县精华助剂有限公司 | Water emulsion type l40 surface active agent |
| CN103039441B (en) * | 2013-01-24 | 2015-01-28 | 凤台县精华助剂有限公司 | Water emulsion type l40 surface active agent |
| CN103655466A (en) * | 2013-11-18 | 2014-03-26 | 河南迪冉生物科技有限公司 | Ivermectin injection and preparation method thereof |
| CN113242747A (en) * | 2018-10-12 | 2021-08-10 | 好利安科技有限公司 | Macrolide formulations, method for preparing them and use of said formulations in the treatment of diseases secondary to ocular parasites |
| CN113242747B (en) * | 2018-10-12 | 2023-09-08 | 好利安科技有限公司 | Macrolide formulations, methods of preparation and use of said formulations in the treatment of diseases secondary to ocular parasites |
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Application publication date: 20120704 |