CN114630663A - 用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物 - Google Patents

用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物 Download PDF

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CN114630663A
CN114630663A CN202180006008.7A CN202180006008A CN114630663A CN 114630663 A CN114630663 A CN 114630663A CN 202180006008 A CN202180006008 A CN 202180006008A CN 114630663 A CN114630663 A CN 114630663A
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Abstract

本发明涉及用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物。具体地，本发明涉及一种线粒体氧化磷酸化通路抑制剂的用途，用于制备组合物或制剂，所述组合物或制剂用于预防和/或治疗肿瘤。本发明发现线粒体氧化磷酸化通路抑制剂对线粒体氧化磷酸化通路上调、NNMT基因低表达或未表达、DNA甲基化酶高表达、UHRF1高表达、NNMT基因核苷酸位点甲基化水平高和/或NNMT基因区DNA CpG位点甲基化水平高的肿瘤具有显著优异的治疗效果。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN202180006008.7A 2020-09-27 2021-09-27 用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物 Active CN114630663B (zh)

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CN2020110345672 2020-09-27
PCT/CN2021/121088 WO2022063311A1 (zh) 2020-09-27 2021-09-27 用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物

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CN114432307A (zh) * 2020-11-06 2022-05-06 南京施江医药科技有限公司 黄连碱类药物在治疗肿瘤中的应用
CN115721655A (zh) * 2021-08-27 2023-03-03 南京施江医药科技有限公司 四环素类药物在治疗肿瘤中的应用
WO2023174381A1 (zh) * 2022-03-16 2023-09-21 南京施江医药科技有限公司 一种含氮杂环类化合物及其用途

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CN106248946A (zh) * 2016-08-19 2016-12-21 浙江大学 一种酶联免疫检测试剂盒及其应用
US20200102274A1 (en) * 2017-03-30 2020-04-02 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof
WO2020086830A2 (en) * 2018-10-26 2020-04-30 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer

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KR20180044617A (ko) * 2016-10-24 2018-05-03 아주대학교산학협력단 Uhrf1 및 dnmt1을 포함하는 세포 노화 진단용 바이오마커 조성물
CN114432307A (zh) * 2020-11-06 2022-05-06 南京施江医药科技有限公司 黄连碱类药物在治疗肿瘤中的应用
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CN106248946A (zh) * 2016-08-19 2016-12-21 浙江大学 一种酶联免疫检测试剂盒及其应用
US20200102274A1 (en) * 2017-03-30 2020-04-02 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof
WO2020086830A2 (en) * 2018-10-26 2020-04-30 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer

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CN114630663B (zh) 2024-07-26
EP4218752A1 (en) 2023-08-02
CA3228855A1 (en) 2022-03-31
JP2023544226A (ja) 2023-10-20
EP4218752A4 (en) 2024-04-10
US20230355647A1 (en) 2023-11-09

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