CN114617908A - Efficient radix bupleuri impurity removal process - Google Patents
Efficient radix bupleuri impurity removal process Download PDFInfo
- Publication number
- CN114617908A CN114617908A CN202210144878.7A CN202210144878A CN114617908A CN 114617908 A CN114617908 A CN 114617908A CN 202210144878 A CN202210144878 A CN 202210144878A CN 114617908 A CN114617908 A CN 114617908A
- Authority
- CN
- China
- Prior art keywords
- bupleurum
- radix bupleuri
- membrane
- purification
- impurities
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012535 impurity Substances 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims abstract description 39
- 230000008569 process Effects 0.000 title claims abstract description 30
- 238000000926 separation method Methods 0.000 claims abstract description 29
- 238000000746 purification Methods 0.000 claims abstract description 26
- 238000012216 screening Methods 0.000 claims abstract description 16
- 239000000428 dust Substances 0.000 claims abstract description 12
- 238000005516 engineering process Methods 0.000 claims abstract description 8
- 241000510654 Bupleurum chinense Species 0.000 claims abstract description 4
- 241000202726 Bupleurum Species 0.000 claims description 53
- 239000012528 membrane Substances 0.000 claims description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000003814 drug Substances 0.000 claims description 25
- 238000005406 washing Methods 0.000 claims description 18
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 16
- 238000004140 cleaning Methods 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 12
- 241000411851 herbal medicine Species 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 9
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 229910052742 iron Inorganic materials 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 238000000108 ultra-filtration Methods 0.000 claims description 7
- 229920000742 Cotton Polymers 0.000 claims description 4
- 239000004952 Polyamide Substances 0.000 claims description 4
- 230000001680 brushing effect Effects 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 239000000084 colloidal system Substances 0.000 claims description 4
- 230000007797 corrosion Effects 0.000 claims description 4
- 238000005260 corrosion Methods 0.000 claims description 4
- 238000007865 diluting Methods 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims description 4
- 239000000696 magnetic material Substances 0.000 claims description 4
- 239000006148 magnetic separator Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229920002492 poly(sulfone) Polymers 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920000098 polyolefin Polymers 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 238000005096 rolling process Methods 0.000 claims description 4
- 238000007790 scraping Methods 0.000 claims description 4
- 238000010008 shearing Methods 0.000 claims description 4
- 239000004575 stone Substances 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 230000003670 easy-to-clean Effects 0.000 claims description 3
- 244000236521 Bupleurum rotundifolium Species 0.000 abstract description 20
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 abstract description 20
- 238000007885 magnetic separation Methods 0.000 abstract description 8
- 239000000243 solution Substances 0.000 description 11
- 230000008859 change Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 244000026811 Brassica nipposinica Species 0.000 description 1
- 241000213015 Bupleurum scorzonerifolium Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038084 Rectocele Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a high-efficiency impurity removing process for radix bupleuri. In the invention, single equipment such as air separation, screening, selection, magnetic separation and the like is optimally combined and designed, and is provided with a plurality of conveying devices, dust collectors and the like to form an automatic complete set of purification equipment which mainly adopts mechanical purification such as air separation, screening, magnetic separation and the like and combines manual auxiliary selection, and the bupleurum chinense is subjected to multidirectional purification treatment. The machine set is provided with a mechanical selecting conveyor, and sundries which cannot be removed in a mechanical mode are manually treated. Because the Chinese thorowax roots are various in types and large in difference in physical form, different Chinese thorowax roots have different purification requirements and the like, the machine set organically combines the traditional purification requirement with the modern processing technology, so that the purification processing of the Chinese thorowax roots develops towards the directions of mechanization, automation and high efficiency, the efficiency and the precision in the impurity removing process of the Chinese thorowax roots are improved, and the Chinese thorowax roots can be purer.
Description
Technical Field
The invention belongs to the technical field of radix bupleuri impurity removal, and particularly relates to an efficient radix bupleuri impurity removal process.
Background
Bupleurum root, the name of Chinese medicine. Is a herbal medicine recorded in Chinese pharmacopoeia, and the medicinal part is dried root of Bupleurum chinense or Bupleurum scorzonerifolium of Umbelliferae. Collected in spring and autumn, removed stems and leaves and silt, and dried. Bupleurum root, radix bupleuri is a commonly used exterior-releasing drug. Is also called as Diwu, potherb mustard, mushroom grass and firewood, is bitter in nature and taste, slightly cold, and enters liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.
During the use process of the radix bupleuri, impurity removal treatment needs to be carried out on the radix bupleuri to remove impurities, but the impurity removal efficiency of a common impurity removal method is low.
Disclosure of Invention
The invention aims to: in order to solve the problems, an efficient bupleurum impurity removing process is provided.
The technical scheme adopted by the invention is as follows: an efficient radix bupleuri impurity removal process comprises the following steps:
s1, checking the bupleurum root in the bupleurum root to be selected, weighing and recording; then adopting sorting, winnowing, screening, shearing, scraping, eliminating, brushing and string rolling methods according to the process requirements respectively to remove impurities or separate and remove non-medicinal parts so that the radix bupleuri meets the quality standard requirement of cleaning;
s2, washing the radix bupleuri by using a medicine washing machine and a water washing pool; removing silt and impurities in the bupleurum, according to the purpose of bupleurum cleaning,
s3, the coming belt magnetic separator automatically removes the iron substances in the bupleurum root including the iron-containing sandstone by using the high-strength magnetic material;
s4, taking a variable frequency winnowing machine, and removing non-medicine and medicinal impurities such as hair, cotton yarn and medicine scraps in the radix bupleuri by using a small wind speed; removing non-medicinal impurities such as stone, silt and the like in the radix bupleuri at a higher wind speed;
s5, selecting a vacuum gas-phase replacement type herbal medicine infiltrating machine, using the characteristic that gas has strong penetrability and high vacuum technology to replace air in the radix bupleuri with water vapor so as to rapidly and uniformly soften the radix bupleuri,
s6, selecting 100 to 200 portions of bupleurum in the step S5, decocting and extracting, and adding 1800 to 2000 portions of deionized water for decocting;
s7, filtering with double-layer gauze, collecting filtrate, adding deionized water 8 times of the crude drug into the residue, decocting for 1h, filtering with double-layer gauze, mixing filtrates, and diluting to a constant volume to obtain water extract containing crude drug 0.1 g/mL;
s8, selecting the selective permeable membrane as a separation medium, and selecting the permeable membrane of the raw material under the pushing of the forces on two sides of the membrane to achieve the purpose of separation and purification;
s9, taking a porous semipermeable membrane as a medium, and filtering and removing impurities in a cross-flow mode; the pore diameter of the ultrafiltration membrane is extremely small, and various particles, colloids and macromolecular solutes in the solution can be blocked, so that the aim of concentration or purification and impurity removal is fulfilled;
s10: and then collecting and storing the filtrate obtained in the step S9, so that the bupleurum chinense subjected to impurity removal can be obtained, and the whole preparation process is finished.
In a preferred embodiment, in step S1, a worktable should be provided for picking bupleurum root, and the surface of the worktable should be flat and not easy to generate falling objects; a dust catching and collecting facility is required to be arranged in an operation room with large dust such as air separation, screening and the like; passing the product to the next procedure or entering a clean material warehouse after the product is qualified through quality inspection.
In a preferred embodiment, in step S2, the interior surface of the apparatus or facility for washing bupleurum should be smooth, bright, easily cleaned, corrosion resistant, and not chemically changed or adsorbed with bupleurum, the bupleurum washing should use flowing water, the used water should not be used for washing other bupleurum, and different bupleurum should not be washed together.
In a preferred embodiment, after the step S4, the impurities of bupleurum root should be manually picked again to remove the adhering impurities in bupleurum root.
In a preferred embodiment, in step S6, decocting is carried out at 100 deg.C for 1 h.
In a preferred embodiment, in step S9, the porous semi-permeable membrane is one of a cellulose membrane, a polysulfone membrane, a polyamide membrane, a polyester membrane, and a polyolefin membrane.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. in the invention, single equipment such as air separation, screening, selection, magnetic separation and the like is optimally combined and designed, and is provided with a plurality of conveying devices, dust collectors and the like to form an automatic complete set of purification equipment which mainly adopts mechanical purification such as air separation, screening, magnetic separation and the like and combines manual auxiliary selection, and the bupleurum is subjected to multidirectional purification treatment. The machine set is provided with a mechanical selecting conveyor, and sundries which cannot be removed in a mechanical mode are manually treated. Because the Chinese thorowax roots are various in types and large in difference in physical form, different Chinese thorowax roots have different purification requirements and the like, the machine set organically combines the traditional purification requirement with the modern processing technology, so that the purification processing of the Chinese thorowax roots develops towards the directions of mechanization, automation and high efficiency, the efficiency and the precision in the impurity removing process of the Chinese thorowax roots are improved, and the Chinese thorowax roots can be purer.
2. In the invention, the porous semipermeable membrane is used for filtration, the operation can be carried out at normal temperature, repeated heating is not needed, and no phase change is generated during separation, so that the preparation is particularly suitable for Chinese herbal medicine preparations which are easy to damage heated effective components, have flavor preservation and react with chemical substances; separation and concentration can be realized simultaneously, and the process efficiency is greatly improved; solutes with different molecular weights can be separated, which is favored in the preparation of Chinese herbal medicine preparations, especially injections; wide selection range and strong applicability. The ultrafiltration membrane separation process is not only suitable for separating organic matters and inorganic matters from viruses and bacteria to particles, but also suitable for separating a plurality of special solution systems, such as azeotrope or near azeotrope, and provides a wide space for meeting the diversified requirements of traditional Chinese medicine production.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
the efficient bupleurum impurity removing process comprises the following steps:
s1, checking the bupleurum root in the bupleurum root to be selected, weighing and recording; then adopting the methods of sorting, winnowing, screening, shearing, scraping, eliminating, brushing and rolling according to the process requirements to remove impurities or separate and remove non-medicinal parts so that the radix bupleuri meets the quality standard requirements of cleaning and sorting; in the step S1, a worktable is arranged for selecting the radix bupleuri, the surface of the worktable is smooth, and falling objects are not easy to generate; a dust catching and collecting facility is required to be arranged in an operation room with large dust such as air separation, screening and the like; passing the product to the next procedure or entering a clean material warehouse after the product is qualified through quality inspection;
s2, washing the radix bupleuri by using a medicine washing machine and a water washing pool; removing silt and impurities in the radix bupleuri, according to the purpose of cleaning the radix bupleuri, in the step S2, the inner surface of equipment or facilities for cleaning the radix bupleuri is smooth, bright and clean, easy to clean and corrosion-resistant, does not chemically change or adsorb the radix bupleuri, the radix bupleuri is cleaned by using flowing water, the used water cannot be used for cleaning other radix bupleuri, and different radix bupleuri cannot be cleaned together;
s3, the coming belt magnetic separator automatically removes the iron substances in the bupleurum root including the iron-containing sandstone by using the high-strength magnetic material;
s4, taking a variable frequency winnowing machine, and removing non-medicine and medicinal impurities such as hair, cotton yarn and medicine scraps in the radix bupleuri by using a small wind speed; removing non-medicinal impurities such as stone, silt and the like in the radix bupleuri at a high wind speed; in step S4, after the process is finished, the impurities of bupleurum root are manually selected and taken out again, the impurities attached to bupleurum root are selected and removed, the single equipment such as air separation, screening, selection and magnetic separation is optimally combined and designed, and a plurality of conveying devices, dust collectors and the like are arranged to form an automatic complete set of cleaning equipment which mainly comprises air separation, screening, magnetic separation and the like, and manual auxiliary selection is combined to perform multidirectional cleaning treatment on the bupleurum root. The machine set is provided with a mechanical selecting conveyor, and sundries which cannot be removed in a mechanical mode are manually treated. Because the Chinese thorowax roots are various in types and large in physical form difference, different Chinese thorowax roots have different purification requirements and the like, the machine set organically combines the traditional purification requirements with the modern processing technology, so that the purification processing of the Chinese thorowax roots develops towards the directions of mechanization, automation and high efficiency, the efficiency and the precision in the impurity removing process of the Chinese thorowax roots are improved, and the Chinese thorowax roots can be purer;
s5, selecting a vacuum gas phase replacement type herbal medicine infiltrating machine, using the characteristic that gas has strong penetrability and a high vacuum technology to replace air in the radix bupleuri with water vapor so as to rapidly and uniformly soften the radix bupleuri, and decocting the radix bupleuri for 1h at 100 ℃ in the step S6;
s6, selecting 100 parts of radix bupleuri in the step S5, decocting and extracting, and adding 1800 deionized water for decocting;
s7, filtering with double-layer gauze, collecting filtrate, adding deionized water 8 times of the crude drug into the residue, decocting for 1h, filtering with double-layer gauze, mixing filtrates, and diluting to a constant volume to obtain water extract containing crude drug 0.1 g/mL;
s8, selecting the selective permeable membrane as a separation medium, and selecting the permeable membrane of the raw material under the pushing of the forces on two sides of the membrane to achieve the purpose of separation and purification;
s9, filtering and removing impurities in a cross flow mode by using a porous semipermeable membrane as a medium; the aperture of the ultrafiltration membrane is extremely small, and various particles, colloids and macromolecular solutes in the solution can be blocked, so that the purpose of concentration or purification and impurity removal is achieved; in step S9, the porous semi-permeable membrane is one of a cellulose membrane, a polysulfone membrane, a polyamide membrane, a polyester membrane, and a polyolefin membrane;
s10: then collecting and storing the filtrate obtained in the step S9, thereby obtaining bupleurum with good impurity removal, finishing the whole preparation process, filtering by a porous semipermeable membrane, operating at normal temperature without repeated heating, having no phase change during separation, and being especially suitable for Chinese herbal medicine preparations with easily damaged heated effective components, flavor preservation and chemical substance reaction; separation and concentration can be realized simultaneously, and the process efficiency is greatly improved; solutes with different molecular weights can be separated, which is favored in the preparation of Chinese herbal medicine preparations, especially injections; wide selection range and strong applicability. The ultrafiltration membrane separation process is not only suitable for separating organic matters and inorganic matters from viruses and bacteria to particles with wide range, but also suitable for separating a plurality of special solution systems, such as azeotrope or near azeotrope, and provides wide space for meeting the diversified requirements of traditional Chinese medicine production.
The second embodiment:
the efficient bupleurum impurity removing process comprises the following steps:
s1, checking the bupleurum root in the bupleurum root to be selected, weighing and recording; then adopting the methods of sorting, winnowing, screening, shearing, scraping, eliminating, brushing and rolling according to the process requirements to remove impurities or separate and remove non-medicinal parts so that the radix bupleuri meets the quality standard requirements of cleaning and sorting; in the step S1, a worktable is arranged for selecting the radix bupleuri, the surface of the worktable is smooth, and falling objects are not easy to generate; a dust catching and collecting facility is required to be arranged in an operation room with large dust such as air separation, screening and the like; passing the product to the next procedure or entering a clean material warehouse after the product is qualified through quality inspection;
s2, washing the radix bupleuri by using a medicine washing machine and a water washing pool; removing silt and impurities in the radix bupleuri, according to the purpose of cleaning the radix bupleuri, in the step S2, the inner surface of equipment or facilities for cleaning the radix bupleuri is smooth, bright and clean, easy to clean and corrosion-resistant, does not chemically change or adsorb the radix bupleuri, the radix bupleuri is cleaned by using flowing water, the used water cannot be used for cleaning other radix bupleuri, and different radix bupleuri cannot be cleaned together;
s3, the coming belt magnetic separator automatically removes the iron substances in the bupleurum root including the iron-containing sandstone by using the high-strength magnetic material;
s4, taking a variable frequency winnowing machine, and removing non-medicine and medicinal impurities such as hair, cotton yarn and medicine scraps in the radix bupleuri by using a small wind speed; removing non-medicinal impurities such as stone, silt and the like in the radix bupleuri at a high wind speed; in step S4, after the process is finished, the impurities of bupleurum root are manually selected and taken out again, the impurities attached to bupleurum root are selected and removed, the single equipment such as air separation, screening, selection and magnetic separation is optimally combined and designed, and a plurality of conveying devices, dust collectors and the like are arranged to form an automatic complete set of cleaning equipment which mainly comprises air separation, screening, magnetic separation and the like, and manual auxiliary selection is combined to perform multidirectional cleaning treatment on the bupleurum root. The machine set is provided with a mechanical selecting conveyor, and sundries which cannot be removed in a mechanical mode are manually treated. Because the Chinese thorowax roots are various in types and large in physical form difference, different Chinese thorowax roots have different purification requirements and the like, the machine set organically combines the traditional purification requirements with the modern processing technology, so that the purification processing of the Chinese thorowax roots develops towards the directions of mechanization, automation and high efficiency, the efficiency and the precision in the impurity removing process of the Chinese thorowax roots are improved, and the Chinese thorowax roots can be purer;
s5, selecting a vacuum gas phase replacement type herbal medicine infiltrating machine, using the characteristic that gas has strong penetrability and a high vacuum technology to replace air in the radix bupleuri with water vapor so as to rapidly and uniformly soften the radix bupleuri, and decocting the radix bupleuri for 1h at 100 ℃ in the step S6;
s6, selecting 200 parts of radix bupleuri in the step S5, decocting and extracting, and adding 2000 deionized water for decocting;
s7, filtering with double-layer gauze, collecting filtrate, adding deionized water 8 times of the crude drug into the residue, decocting for 1h, filtering with double-layer gauze, mixing filtrates, and diluting to a constant volume to obtain water extract containing crude drug 0.1 g/mL;
s8, selecting the selective permeable membrane as a separation medium, and selecting the permeable membrane of the raw material under the pushing of the forces on two sides of the membrane to achieve the purpose of separation and purification;
s9, taking a porous semipermeable membrane as a medium, and filtering and removing impurities in a cross-flow mode; the aperture of the ultrafiltration membrane is extremely small, and various particles, colloids and macromolecular solutes in the solution can be blocked, so that the purpose of concentration or purification and impurity removal is achieved; in step S9, the porous semi-permeable membrane is one of a cellulose membrane, a polysulfone membrane, a polyamide membrane, a polyester membrane, and a polyolefin membrane;
s10: then collecting and storing the filtrate obtained in the step S9, thereby obtaining bupleurum with good impurity removal, finishing the whole preparation process, filtering by a porous semipermeable membrane, operating at normal temperature without repeated heating, having no phase change during separation, and being especially suitable for Chinese herbal medicine preparations with easily damaged heated effective components, flavor preservation and chemical substance reaction; separation and concentration can be realized simultaneously, and the process efficiency is greatly improved; solutes with different molecular weights can be separated, which is favored in the preparation of Chinese herbal medicine preparations, especially injections; wide selection range and strong applicability. The ultrafiltration membrane separation process is not only suitable for separating organic matters and inorganic matters from viruses and bacteria to particles with wide range, but also suitable for separating a plurality of special solution systems, such as azeotrope or near azeotrope, and provides wide space for meeting the diversified requirements of traditional Chinese medicine production.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (6)
1. An efficient impurity removal process for radix bupleuri is characterized in that: the efficient bupleurum impurity removing process comprises the following steps:
s1, checking the bupleurum root in the bupleurum root to be selected, weighing and recording; then adopting the methods of sorting, winnowing, screening, shearing, scraping, eliminating, brushing and rolling according to the process requirements to remove impurities or separate and remove non-medicinal parts so that the radix bupleuri meets the quality standard requirements of cleaning and sorting;
s2, washing the radix bupleuri by using a medicine washing machine and a water washing pool; removing silt and impurities in the bupleurum, according to the purpose of bupleurum cleaning,
s3, the coming belt magnetic separator automatically removes the iron substances in the bupleurum root including the iron-containing sandstone by using the high-strength magnetic material;
s4, taking a variable frequency winnowing machine, and removing non-medicine and medicinal impurities such as hair, cotton yarn and medicine scraps in the radix bupleuri by using a small wind speed; removing non-medicinal impurities such as stone, silt and the like in the radix bupleuri at a high wind speed;
s5, selecting a vacuum gas-phase replacement type herbal medicine infiltrating machine, using the characteristic that gas has strong penetrability and high vacuum technology to replace air in the radix bupleuri with water vapor so as to rapidly and uniformly soften the radix bupleuri,
s6, selecting 100 to 200 portions of bupleurum in the step S5, decocting and extracting, and adding 1800 to 2000 portions of deionized water for decocting;
s7, filtering with double-layer gauze, collecting filtrate, adding deionized water 8 times of the crude drug into the residue, decocting for 1h, filtering with double-layer gauze, mixing filtrates, and diluting to a constant volume to obtain water extract containing crude drug 0.1 g/mL;
s8, selecting the selective permeable membrane as the separation medium, and under the push of the forces on the two sides of the membrane, selecting the permeable membrane of the raw material row to achieve the purpose of separation and purification;
s9, filtering and removing impurities in a cross flow mode by using a porous semipermeable membrane as a medium; the aperture of the ultrafiltration membrane is extremely small, and various particles, colloids and macromolecular solutes in the solution can be blocked, so that the purpose of concentration or purification and impurity removal is achieved;
s10: and then collecting and storing the filtrate obtained in the step S9, so that the bupleurum chinense subjected to impurity removal can be obtained, and the whole preparation process is finished.
2. The efficient bupleurum impurity removing process as claimed in claim 1, which is characterized in that: in the step S1, a worktable is arranged for selecting the radix bupleuri, the surface of the worktable is smooth, and falling objects are not easy to generate; a dust catching and collecting facility is required to be arranged in an operation room with large dust such as air separation, screening and the like; passing the product to the next procedure or entering a clean material warehouse after the product is qualified through quality inspection.
3. The efficient bupleurum impurity removing process as claimed in claim 1, which is characterized in that: in step S2, the interior surface of the device or facility for washing bupleurum should be smooth, clean, easy to clean, corrosion resistant, and not chemically changed or adsorbed with bupleurum, the bupleurum washing should use flowing water, the used water should not be used for washing other bupleurum, different bupleurum should not be washed together.
4. The efficient bupleurum impurity removing process as claimed in claim 1, which is characterized in that: in step S4, after the process is finished, the impurities of bupleurum root should be manually picked out again to remove the attached impurities in bupleurum root.
5. The efficient bupleurum impurity removing process as claimed in claim 1, which is characterized in that: in the step S6, decocting at 100 ℃ for 1 h.
6. The efficient bupleurum impurity removing process as claimed in claim 1, which is characterized in that: in step S9, the porous semi-permeable membrane is one of a cellulose membrane, a polysulfone membrane, a polyamide membrane, a polyester membrane, and a polyolefin membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210144878.7A CN114617908A (en) | 2022-02-17 | 2022-02-17 | Efficient radix bupleuri impurity removal process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210144878.7A CN114617908A (en) | 2022-02-17 | 2022-02-17 | Efficient radix bupleuri impurity removal process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114617908A true CN114617908A (en) | 2022-06-14 |
Family
ID=81899747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210144878.7A Pending CN114617908A (en) | 2022-02-17 | 2022-02-17 | Efficient radix bupleuri impurity removal process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114617908A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177670A (en) * | 2022-08-29 | 2022-10-14 | 王立正 | Pharmaceutical composition with constipation relieving effect |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530439A (en) * | 2008-01-22 | 2009-09-16 | 上海中药制药技术有限公司 | Method for preparing bupleurum extract by applying membrane filtration technology |
| CN108714159A (en) * | 2018-06-15 | 2018-10-30 | 陕西广济堂医药集团股份有限公司 | A kind of Bupleurum Chinese refines the production method of medicine materical crude slice |
-
2022
- 2022-02-17 CN CN202210144878.7A patent/CN114617908A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530439A (en) * | 2008-01-22 | 2009-09-16 | 上海中药制药技术有限公司 | Method for preparing bupleurum extract by applying membrane filtration technology |
| CN108714159A (en) * | 2018-06-15 | 2018-10-30 | 陕西广济堂医药集团股份有限公司 | A kind of Bupleurum Chinese refines the production method of medicine materical crude slice |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177670A (en) * | 2022-08-29 | 2022-10-14 | 王立正 | Pharmaceutical composition with constipation relieving effect |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103479682A (en) | Preparation method for plant source active component nano-scale membrane type vesicle | |
| CN106866759B (en) | The technique of grosvenor momordica flavonoid is produced from the waste liquid that Momordica-Glycosides decolorizing resin column is discharged | |
| CN107556283A (en) | A kind of process of the extraction of the efficient low-consume from grape pip OPC | |
| CN114617908A (en) | Efficient radix bupleuri impurity removal process | |
| CN105622775A (en) | Nostoc sphaeroides polysaccharide and extracting method thereof | |
| CN104224911B (en) | A kind of new Salvia root P.E and its preparation | |
| JP6473803B2 (en) | Extraction method of chlorogenic acid from Tochu leaves | |
| CN112980765A (en) | Method for extracting high-purity centella asiatica exosome | |
| CN106008211A (en) | Method for extraction of cynarin from cynara scolymus by membrane integration technology | |
| CN1476892A (en) | Method for separating effertive components of Chinese medicine by adopting membrane technique | |
| CN106561894B (en) | Preparation method of high-tea-polyphenol instant green tea powder and instant green tea powder | |
| CN107473979A (en) | A kind of processing method of film extraction theanine | |
| CN106278934B (en) | The separating and extracting process of six kinds of amide alkaloids in Sabia parviflora Wall.ex Roxb | |
| CN107961253A (en) | A kind of Taxus extracts through detoxification treatment and preparation method thereof | |
| CN101792394B (en) | Extraction separation method of L-synephrine | |
| CN111548380A (en) | Preparation method of monotropein in morinda officinalis | |
| CN110256431A (en) | The extraction of biology total alkali and separation purifying technique in a kind of kuh-seng | |
| CN109251252A (en) | A kind of technique that membrane separation technique combines cooling precipitation method to prepare tea polysaccharide, tea polyphenols, caffeine and theanine | |
| CN111116768A (en) | Method for recovering baicalein from baicalin production waste liquid | |
| CN104857108A (en) | Method for preparing hawthorn extractive through continuous countercurrent ultrasonic equipment | |
| CN108192726A (en) | A kind of preparation method of cigarette tree moss absolute | |
| CN106420492A (en) | Rapid preparation method of portulaca oleracea contained anti-allergy soothing liquid | |
| CN107082791A (en) | A kind of method that phenylethanoid glycosides are extracted from saline cistanche | |
| CN102274403A (en) | Method for extracting total alkaloids from liparis nervosa | |
| CN108191762A (en) | A kind of extracting method of pure natural heavy metal free Huperzine Serrate P.E |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220614 |
|
| RJ01 | Rejection of invention patent application after publication |