CN108714159A - A kind of Bupleurum Chinese refines the production method of medicine materical crude slice - Google Patents

A kind of Bupleurum Chinese refines the production method of medicine materical crude slice Download PDF

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Publication number
CN108714159A
CN108714159A CN201810618089.6A CN201810618089A CN108714159A CN 108714159 A CN108714159 A CN 108714159A CN 201810618089 A CN201810618089 A CN 201810618089A CN 108714159 A CN108714159 A CN 108714159A
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materical crude
crude slice
medicine materical
bupleurum chinese
medicine
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张晶晶
王小鹏
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Shaanxi Guangjin Pharmaceutical Group Ltd By Share Ltd
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Shaanxi Guangjin Pharmaceutical Group Ltd By Share Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/13Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/17Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of Bupleurum Chinese refine medicine materical crude slice production method, including select, clean bored profit, cutting, primary screening, drying, postsearch screening, it is selected obtain refined Bupleurum Chinese medicine materical crude slice after packed automatically.The present invention excellent beneficial effect be:Cleaning uses roller medicine-washing machine, improves production efficiency compared to traditional wash method, and cleaning is more thorough, scavenging period automatically controls;Slice carries out cutting with high speed reciprocating medicine cutter, and high degree of automation, cutting thickness is adjustable:It is dry to use band drier, it can in time, efficiently be dried, product quality is improved to be dried, medicine materical crude slice after drying removes irregular piece, Special-shaped sheet, medicine bits etc., substantially increases final product quality by screening twice, entire production technology uses the full-automatic Production line equipment of independent research, speed of production is high, the huge market demand, favorable comment of the product by numerous medical staff and patient.

Description

A kind of Bupleurum Chinese refines the production method of medicine materical crude slice
Technical field
The invention belongs to the preparing technical fields of the prepared slices of Chinese crude drugs, and in particular to a kind of Bupleurum Chinese refines the producer of medicine materical crude slice Method.
Background technology
Currently, traditional Chinese medicine receives the very big attention of international community with its remarkable curative effect and unique advantage.Chinese medicine package Include Chinese medicine, the prepared slices of Chinese crude drugs, the three big pillars that Chinese patent drug is Chinese herbal medicine industry.The prepared slices of Chinese crude drugs are necessary to TCM differentiation treats The important source material of traditional weapon and Chinese patent drug, unique processing theory and method, embody the profound of ancient Chinese medicine invariably Wisdom.With the constantly improve and maturation that its processing is theoretical, the important means that it has become tcm clinical practice diseases prevention, cures the disease.Not only such as This, the prepared slices of Chinese crude drugs can face card plus-minus, have great flexibility, so the prepared slices of Chinese crude drugs have broad application prospects.
Chinese medicine Bupleurum Chinese is umbelliferae bupleurum Bupleurum chinense DC. or radix bupleuri scorzoneraefolii Bupleurum There is evacuation to bring down a fever for the dry root of scorzonerifolium Willd., gas micro-perfume mildly bitter flavor, and soothing liver-qi stagnation rises and lifts yang-energy The effect of, it can be used for cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, the prolapse of uterus, the treatment of rectal prolapse.Bupleurum Chinese is drunk Piece is widely used, but in the prior art, Bupleurum Chinese medicine materical crude slice production technology falls behind, and causes Bupleurum Chinese prepared slice quality low, is facing Application effect is poor in bed use.
Invention content
The goal of the invention of the present invention is:In view of the above problems, a kind of production of the refined medicine materical crude slice of Bupleurum Chinese is provided Method, this method are produced and processed to " prepared slices of Chinese crude drugs cutting automatic assembly line " of independent research, produce Bupleurum Chinese essence Prepared slice quality processed is reliable, and clinical application effect is good, by numerous medical staff favorable comment consistent with patient.
The technical solution adopted by the present invention is:A kind of the step of production method of the refined medicine materical crude slice of Bupleurum Chinese, production, is as follows:
(a) Bupleurum Chinese for meeting processing is selected;(b) Bupleurum Chinese that cleaning is picked out obtains clean Bupleurum Chinese;(c) to described clear The Bupleurum Chinese of wash clean carries out bored profit;(d) the bored Bupleurum Chinese moisturized described in cutting obtains common medicine materical crude slice;(e) to the common drink Piece carry out primary screening, drying,
(f) to the primary screening, it is dry after common medicine materical crude slice carry out postsearch screening, selected obtain refined medicine materical crude slice;(h) automatic packet Dress refines Bupleurum Chinese and refines medicine materical crude slice.
In technical solution of the present invention, the cleaning of Bupleurum Chinese uses roller medicine-washing machine, and life is improved compared to traditional wash method Efficiency is produced, and cleaning is more thorough, scavenging period automatically controls;Slice carries out cutting with high speed reciprocating medicine cutter, automates Degree is high, and cutting thickness is adjustable:It is dry to use band drier, it can in time, efficiently be dried, improve product quality and carry out It is dry, it is dry after medicine materical crude slice by screening twice, remove irregular piece, Special-shaped sheet, medicine bits etc., substantially increase final product quality, Entire production technology uses the full-automatic Production line equipment of independent research, and speed of production is made to be greatly improved.
The thickness of preferred embodiments of the present invention, the common medicine materical crude slice is 2-4mm, which meets《Chinese people's republicanism State's pharmacopeia》The quality standard of the middle Bupleurum Chinese medicine materical crude slice of version one in 2015.
Preferred embodiments of the present invention the common medicine materical crude slice are dried using band drier, drying temperature 60- 80 DEG C, layer thickness 2-3cm, conveyer belt rotating speed is 30-50r/s, water content when Bupleurum Chinese medicine materical crude slice being made to go out drying machine≤ 10.0%。
Preferred embodiments of the present invention pack the refined medicine materical crude slice automatically.
As a result of above-mentioned production equipment, production efficiency is improved;It is dispensed with polybag, facilitates storage and transportation, reduced Medicine pollution phenomenon, to ensure that the safety of clinical application.
In conclusion by adopting the above-described technical solution, the beneficial effects of the invention are as follows:
1. increasing dry front and back screening process, final product quality is improved.
2. entire production technology uses the full-automatic Production line equipment of independent research, production efficiency is high, market demand Greatly, favorable comment of the product by numerous medical staff and patient.
Specific implementation mode
Above description is only the general introduction of technical solution of the present invention, in order to better understand the technical means of the present invention, And can be implemented in accordance with the contents of the specification, and in order to allow the above and other objects, features and advantages of the present invention can It is clearer and more comprehensible, the specific embodiment of the invention is described in detail below.
Embodiment one
The present embodiment provides the production methods that a kind of Bupleurum Chinese refines medicine materical crude slice, include the following steps:
1. net system Bupleurum Chinese removes the impurity adhered on root and reed head, shakes off soil, cleaned, obtained with roller medicine-washing machine To clean Bupleurum Chinese.
2. clean Bupleurum Chinese is positioned in demulcen pond, it is capped bored cloth, moistens to the saturating heart, Bupleurum Chinese is made to soften, it is interior without the dry heart, Convenient for cutting, amount of water should ensure that medicine is permeable most, and active ingredient is prevented to be lost in;Bored profit time, regular check are cut in time after moisturizing System, drying, prevent active constituent content from reducing, and ensure finished product drug effect.
3. Bupleurum Chinese is carried out whole, with high speed reciprocating medicine cutter cutting, thickness 2mm obtains common medicine materical crude slice, cuts medicine Medicine cutter is opened in the concrete operations of machine, and trial cut 2min, coupon is thick, and piece shape is qualified, then continues to cut, and the medicine materical crude slice that trial cut goes out is collected Get up, is not mixed with qualified products;If the piece thickness of trial cut is unqualified, medicine cutter need to be adjusted to piece pictograph standardization, collected common Medicine materical crude slice selects lengthy motion picture, sheet and connects blade.
4. the common medicine materical crude slice cut is promoted in screening machine by elevator automatically, select 0.8cm sieves, by it is irregular compared with Big medicine materical crude slice weeds out, and selects 0.2cm sieves, weeds out the medicine bits during cutting, is that Bupleurum Chinese refines medicine materical crude slice among two layers of sieve, It is dried.
5. being dried using band drier, drying temperature is set as 65 DEG C, layer thickness 2-3cm, conveyer belt turns Speed is 45r/s, water content≤10.0% when Bupleurum Chinese medicine materical crude slice being made to go out drying machine.
6. medicine materical crude slice carries out postsearch screening after pair drying, 0.2cm sieves are selected, the medicine in drying process is removed and considers to be worth doing, irregularly Medicine materical crude slice and special-shaped medicine materical crude slice obtain refined medicine materical crude slice.
7. it is pair above-mentioned select after refine medicine materical crude slice and carry out automatic subpackage dress.
Embodiment two
The present embodiment provides the production methods that a kind of Bupleurum Chinese refines medicine materical crude slice, include the following steps:
1. net system Bupleurum Chinese removes the impurity adhered on root and reed head, shakes off soil, cleaned, obtained with roller medicine-washing machine To clean Bupleurum Chinese.
2. clean Bupleurum Chinese is positioned in demulcen pond, it is capped bored cloth, moistens to the saturating heart, Bupleurum Chinese is made to soften, it is interior without the dry heart, Convenient for cutting, amount of water should ensure that medicine is permeable most, and active ingredient is prevented to be lost in, and the bored profit time, regular check is cut in time after moisturizing System, drying, prevent active constituent content from reducing, and ensure finished product drug effect.
3. Bupleurum Chinese is carried out whole, with high speed reciprocating medicine cutter cutting, thickness 3mm obtains common medicine materical crude slice, cuts medicine Medicine cutter is opened in the concrete operations of machine, and trial cut 2min, coupon is thick, and piece is thick qualified, then continues to cut, and the medicine materical crude slice that trial cut goes out is collected Get up, is not mixed with qualified products;If the medicine materical crude slice unqualified thickness lattice of trial cut, medicine cutter need to be adjusted to piece pictograph standardization, collected Common medicine materical crude slice selects lengthy motion picture, sheet and connects blade.
4. the common medicine materical crude slice cut is promoted in screening machine by elevator automatically, select 0.8cm sieves, by it is irregular compared with Big medicine materical crude slice weeds out, and selects 0.2cm sieves, weeds out the medicine bits during cutting, is that Bupleurum Chinese refines medicine materical crude slice among two layers of sieve, It is dried.
5. being dried using band drier, drying temperature is set as 70 DEG C, layer thickness 2-3cm, conveyer belt turns Speed is 40r/s, water content≤10.0% when Bupleurum Chinese medicine materical crude slice being made to go out drying machine.
6. medicine materical crude slice carries out postsearch screening after pair drying, 0.2cm sieves are selected, the medicine in drying process is removed and considers to be worth doing, irregularly Medicine materical crude slice and special-shaped medicine materical crude slice obtain refined medicine materical crude slice.
7. it is pair above-mentioned select after refine medicine materical crude slice and carry out automatic subpackage dress.
Embodiment three
The present embodiment provides the production methods that a kind of Bupleurum Chinese refines medicine materical crude slice, include the following steps:
1. net system Bupleurum Chinese removes the impurity adhered on root and reed head, shakes off soil, cleaned, obtained with roller medicine-washing machine To clean Bupleurum Chinese.
2. clean Bupleurum Chinese is positioned in demulcen pond, it is capped bored cloth, moistens to the saturating heart, Bupleurum Chinese is made to soften, it is interior without the dry heart, Convenient for cutting, amount of water should ensure that medicine is permeable most, and active ingredient is prevented to be lost in, and the bored profit time, regular check is cut in time after moisturizing System, drying, prevent active constituent content from reducing, and ensure finished product drug effect.
3. Bupleurum Chinese is carried out whole, with high speed reciprocating medicine cutter cutting, thickness 4mm obtains common medicine materical crude slice, cuts medicine Medicine cutter is opened in the concrete operations of machine, and trial cut 2min, coupon is thick, and piece is thick qualified, then continues to cut, and the medicine materical crude slice that trial cut goes out is collected Get up, is not mixed with qualified products;If the medicine materical crude slice unqualified thickness lattice of trial cut, medicine cutter need to be adjusted to piece pictograph standardization, collected Common medicine materical crude slice selects lengthy motion picture, sheet and connects blade.
4. the common medicine materical crude slice cut is promoted in screening machine by elevator automatically, select 0.8cm sieves, by it is irregular compared with Big medicine materical crude slice weeds out, and selects 0.2cm sieves, weeds out the medicine bits during cutting, is that Bupleurum Chinese refines medicine materical crude slice among two layers of sieve, It is dried.
5. being dried using band drier, drying temperature is set as 75 DEG C, layer thickness 2-3cm, conveyer belt turns Speed is 35r/s, water content≤10.0% when Bupleurum Chinese medicine materical crude slice being made to go out drying machine.
6. medicine materical crude slice carries out postsearch screening after pair drying, 0.3cm sieves are selected, the medicine in drying process is removed and considers to be worth doing, irregularly Medicine materical crude slice and special-shaped medicine materical crude slice obtain refined medicine materical crude slice.
7. it is pair above-mentioned select after refine medicine materical crude slice and carry out automatic subpackage dress.
The foregoing is merely the preferable implementation examples of the present invention, are not intended to limit the invention, all spirit in the present invention Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.

Claims (8)

1. a kind of Bupleurum Chinese refines the production method of medicine materical crude slice, which is characterized in that the step of production is as follows:
(a) Bupleurum Chinese for meeting processing is selected;(b) Bupleurum Chinese that cleaning is picked out obtains clean Bupleurum Chinese;(c) to described clear The Bupleurum Chinese of wash clean carries out bored profit;(d) the bored Bupleurum Chinese moisturized described in cutting obtains common medicine materical crude slice;(e) to the common drink Piece carry out primary screening, drying, (f) to the primary screening, it is dry after common medicine materical crude slice carry out postsearch screening, selected obtain essence Medicine materical crude slice processed;(h) the refined Bupleurum Chinese medicine materical crude slice of automatic packaging.
2. Bupleurum Chinese according to claim 1 refines the production method of medicine materical crude slice, which is characterized in that cleaning Bupleurum Chinese roller Medicine-washing machine cleans, and ensures that Bupleurum Chinese surface thoroughly cleans up.
3. Bupleurum Chinese according to claim 1 or 2 refines the production method of medicine materical crude slice, which is characterized in that the clean north Radix bupleuri carries out bored profit, bored profit to the saturating heart.
4. Bupleurum Chinese according to claim 1 or 3 refines the production method of medicine materical crude slice, which is characterized in that after described moisturize Bupleurum Chinese cutting be common medicine materical crude slice, cutting piece shape thickness is 2-4mm.
5. Bupleurum Chinese according to claim 1 or 4 refines the production method of medicine materical crude slice, which is characterized in that after the cutting Common medicine materical crude slice carry out primary screening, select 0.8cm sieves, irregular larger medicine materical crude slice is weeded out, then select 0.2cm sieves, The medicine bits during cutting are weeded out, are that Bupleurum Chinese refines medicine materical crude slice among two layers of sieve.
6. Bupleurum Chinese refines the production method of medicine materical crude slice according to claim 1 or 5, which is characterized in that the refined drink Piece is dried using band drier, and drying temperature is 60-80 DEG C, layer thickness 2-3cm, and conveyer belt rotating speed is 30- 50r/s, water content≤10.0% when Bupleurum Chinese medicine materical crude slice being made to go out drying machine.
7. according to claim 1 or 5 Bupleurum Chinese refine medicine materical crude slice production method, which is characterized in that the medicine materical crude slice into 0.2cm sieves are selected in row postsearch screening, are weeded out the bits of the medicine in drying process, irregular medicine materical crude slice and special-shaped medicine materical crude slice and are refined Medicine materical crude slice.
8. Bupleurum Chinese according to claim 7 refines the production method of medicine materical crude slice, which is characterized in that the refined medicine materical crude slice Carry out automatic subpackage dress.
CN201810618089.6A 2018-06-15 2018-06-15 A kind of Bupleurum Chinese refines the production method of medicine materical crude slice Pending CN108714159A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109602831A (en) * 2018-12-28 2019-04-12 成都康美药业生产有限公司 A kind of processing technology of prepared RHIZOMA CYPERI with vinegar
CN109674836A (en) * 2018-12-28 2019-04-26 成都康美药业生产有限公司 A kind of processing preparation process of Rhizoma Chuanxiong
CN110833571A (en) * 2019-12-13 2020-02-25 宁夏隆德县六盘山中药资源开发有限公司 Preparation method of astragalus membranaceus decoction piece finished product
CN110917226A (en) * 2019-11-05 2020-03-27 宁夏明德中药饮片有限公司 Production process of bupleurum chinense
CN114617908A (en) * 2022-02-17 2022-06-14 广东合百草制药有限公司 Efficient radix bupleuri impurity removal process
CN115040555A (en) * 2022-07-27 2022-09-13 广东合百草制药有限公司 Processing method of bupleurum chinense

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CN102552350A (en) * 2012-02-29 2012-07-11 青川德康源药业有限公司 Method for processing bupleurum medicinal slices in producing areas
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CN103099830A (en) * 2013-01-22 2013-05-15 康美药业股份有限公司 Processing method of vinegar-baked bupleurum root and applications thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109602831A (en) * 2018-12-28 2019-04-12 成都康美药业生产有限公司 A kind of processing technology of prepared RHIZOMA CYPERI with vinegar
CN109674836A (en) * 2018-12-28 2019-04-26 成都康美药业生产有限公司 A kind of processing preparation process of Rhizoma Chuanxiong
CN110917226A (en) * 2019-11-05 2020-03-27 宁夏明德中药饮片有限公司 Production process of bupleurum chinense
CN110833571A (en) * 2019-12-13 2020-02-25 宁夏隆德县六盘山中药资源开发有限公司 Preparation method of astragalus membranaceus decoction piece finished product
CN114617908A (en) * 2022-02-17 2022-06-14 广东合百草制药有限公司 Efficient radix bupleuri impurity removal process
CN115040555A (en) * 2022-07-27 2022-09-13 广东合百草制药有限公司 Processing method of bupleurum chinense

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Application publication date: 20181030