CN114606120A - Temperature control device - Google Patents
Temperature control device Download PDFInfo
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- CN114606120A CN114606120A CN202011429905.2A CN202011429905A CN114606120A CN 114606120 A CN114606120 A CN 114606120A CN 202011429905 A CN202011429905 A CN 202011429905A CN 114606120 A CN114606120 A CN 114606120A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
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Abstract
The utility model provides a temperature control device, including the drainage fan, add the heat-insulating material and have the air inlet portion, go out the wind portion and be used for holding the control by temperature change main part of waiting to heat the wind bath cavity of reaction piece, the wind bath cavity passes through air inlet portion and goes out wind portion and external intercommunication, the drainage fan sets up in air inlet portion and/or play wind portion, be used for guiding the air current to flow through air inlet portion in proper order, wind bath cavity and play wind portion, add the heat-insulating material setting in air inlet portion, be used for being connected with temperature control spare electricity, in order to heat the air current of flowing through air inlet portion under the control of temperature control spare. The air is used as a carrier for heat transfer, and the heat exchange process with the reaction part to be heated is completed in a wind bath mode, so that the heat can be quickly transferred to the reaction part to be heated, the temperature change delay of the reaction part to be heated is avoided, and the temperature change process of quickly heating or cooling is realized; and the reaction piece to be heated can be placed in the temperature control main body as required without being limited by factors such as size, number, shape, arrangement mode and the like of the reaction piece to be heated, so that the universality of the device is effectively enhanced.
Description
Technical Field
The invention relates to the field of biomedical detection, in particular to a temperature control device.
Background
Polymerase Chain Reaction (PCR) is a molecular biology technique for amplifying and amplifying specific DNA fragments, and the advent of PCR amplification instruments has enabled the automation of PCR techniques, and has enabled the widespread use of PCR techniques in areas such as genetic disease diagnosis, nucleic acid detection of pathogens in clinical specimens, genetic identification, gene replication, and analysis of mutations in activated oncogenes.
The core of the PCR amplification instrument is equivalent to a temperature control system, and the temperature and time of reactants at different stages of denaturation, renaturation (annealing), extension and the like can be controlled according to different reaction conditions. At present, the PCR amplification apparatus in the prior art mainly utilizes the semiconductor heating plate and the heat conducting module to complete the temperature variation, that is: the semiconductor heating sheet is heated or cooled by applying forward or reverse current to the semiconductor heating sheet, and then the heat or cold is conducted to the reaction tube by the heat conduction module so as to finally control the temperature of contents (such as reagents, biological samples and the like) in the reaction tube. On one hand, however, due to the influence of factors such as difference of heat conductivity coefficients of different media, the temperature change of the contents in the reaction tube has certain hysteresis, so that the speed of regulating and controlling the temperature of the contents is indirectly reduced; on the other hand, the reaction tube and the heat conducting module need to be tightly attached to facilitate heat conduction and ensure that the temperature of the contents is controllable, so the shape, size, number, arrangement mode and the like of the reaction tube are usually required to be kept in fit with the heat conducting module; therefore, the versatility of the temperature control system is greatly limited.
Disclosure of Invention
The invention mainly solves the technical problem of providing a temperature control device so as to achieve the aims of quickly changing temperature and enhancing the universality of the device.
In one embodiment, a temperature control device is provided, comprising:
the temperature control main body is provided with an air bath cavity, an air inlet part and an air outlet part, the air bath cavity is communicated with the outside through the air inlet part and the air outlet part, and the air bath cavity is used for accommodating a reaction piece to be heated;
the drainage fan is used for guiding airflow to sequentially flow through the air inlet part, the air bath cavity and the air outlet part, and is arranged at the air inlet part and/or the air outlet part; and
the heating member for be connected with the temperature control piece electricity, with the air current of heating flow through air inlet portion under the control of temperature control piece, the heating member sets up in air inlet portion.
In one embodiment, the temperature detection piece is arranged in the air bath chamber and used for acquiring temperature information in the air bath chamber and electrically connecting with the temperature control piece so as to output the temperature information to the temperature control piece.
In one embodiment, the air bath chamber is provided with a light-transmitting part made of a light-transmitting material, and the light-transmitting part is used for transmitting light so as to obtain a reaction result by shooting an image of the reaction member to be heated.
In one embodiment, the air bath chamber is provided with an inlet and an outlet, and the reaction piece to be heated is accommodated in the air bath chamber;
the air outlet part is positioned at the top of the air bath cavity, the air inlet part is a plurality of, and the air outlet and the air inlet parts are distributed along the circumferential direction of the air bath cavity.
In one embodiment, the number of the air inlet portions is two, and the two air inlet portions are symmetrically distributed with the air outlet portion as a reference.
In one embodiment, further comprising a flow guide, the flow guide comprising:
the flow guide main board is positioned between the heating element and the air bath cavity and is a plate-shaped structural body of which the peripheral outline shape is matched with the cross section shape of the air inlet part; and
the air guide air inlet is used for uniformly mixing air flowing through the air guide main board, and one or more air guide air inlets are formed in the air guide main board.
In one embodiment, further comprising a flow guide, the flow guide comprising:
the flow guide main pipe is positioned between the heating element and the air bath chamber and is a tubular structural body of which the peripheral outline shape is matched with the cross section shape of the air inlet part; and
guide vane for the mixing flows through the air that the water conservancy diversion was responsible for, guide vane is a plurality of and encircles the central line evenly distributed that the water conservancy diversion was responsible for on the internal perisporium that the water conservancy diversion was responsible for, guide vane is one from the inlet end that the water conservancy diversion was responsible for to giving vent to anger the end and do the curved surface slice structure of slope bending.
In one embodiment, the heating element is a cone structure, the central axis of the heating element coincides with the central line of the air inlet portion, and the cone bottom end of the heating element faces the air bath chamber.
In one embodiment, the heating element comprises:
the outer periphery of the conical framework is provided with a plurality of clamping grooves which are distributed side by side along the axial direction; and
the heating wire is used for being electrically connected with the temperature control part and is wound on the conical framework through the clamping groove.
In one embodiment, the tapered framework is a structure formed by a plurality of supporting plates which are connected in a cross mode or spliced coaxially, and the shape of each supporting plate is at least one of an isosceles trapezoid, an isosceles triangle, a right trapezoid and a right triangle.
According to the temperature control device of above-mentioned embodiment, including the drainage fan, heating member and have air inlet portion, go out the control by temperature change main part of wind bath chamber of portion and being used for holding the reaction piece of waiting to heat, the wind bath chamber passes through air inlet portion and goes out air portion and external intercommunication, the drainage fan sets up in air inlet portion and/or air outlet portion, be used for guiding the air current to flow through air inlet portion in proper order, wind bath chamber and air outlet portion, the heating member sets up in air inlet portion, be used for being connected with temperature control spare electricity, in order to heat the air current of flowing through air inlet portion under the control of temperature control spare. The air is used as a carrier for heat transfer, and the heat exchange process with the reaction part to be heated is completed in a wind bath mode, so that the heat can be quickly transferred to the reaction part to be heated, the temperature change delay of the reaction part to be heated is avoided, and the temperature change process of quickly heating or cooling is realized; and the reaction piece to be heated can be placed in the temperature control main body as required without being limited by factors such as size, number, shape, arrangement mode and the like of the reaction piece to be heated, so that the universality of the device is effectively enhanced.
Drawings
Fig. 1 is a schematic structural assembly diagram of a temperature control device according to an embodiment.
Fig. 2 is an exploded view of a temperature control device according to an embodiment.
Fig. 3 is a schematic view of an air flow path in the temperature control device according to an embodiment.
Fig. 4 is a reference schematic diagram (a) of a structure of a temperature control device in a use state according to an embodiment.
Fig. 5 is a reference schematic diagram (ii) of a structure of a temperature control device in a use state according to an embodiment.
Fig. 6 is an exploded view of a heating element of the temperature control device according to the embodiment.
Fig. 7 is a schematic structural diagram (one) of a flow guide member of the temperature control device according to the embodiment.
Fig. 8 is a schematic structural view (ii) of a flow guide of the temperature control device according to the embodiment.
Fig. 9 is a schematic structural view of a flow guide of the temperature control device in an installation state according to an embodiment.
Fig. 10 is a schematic structural view of the flow guide member in fig. 9.
Fig. 11 is a functional block diagram of a control system of a temperature control device of an embodiment.
In the figure:
10. a temperature control main body; 11. a wind bath chamber; 12. an air inlet part; 13. an air outlet part; 14. an entrance and an exit; 15. a movable door panel; 20. a drainage fan; 30. a heating member; 31. a tapered skeleton; 32. a clamping groove; 33. heating wires; 40. a temperature detection member; 50. a flow guide member; 51. a flow guiding main board; 52. a flow guiding tuyere; 53. inclining the flow guide surface; 54. a flow guide main pipe; 55. a guide vane; A. a reaction member to be heated; B. and (5) a temperature control piece.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).
At present, a temperature control device represented by a PCR amplification apparatus generally adopts a structure of: an aluminum plate bracket is arranged on the semiconductor heating sheet, and a plurality of concave structures are sequentially arranged on the bracket. When detection reaction heating is carried out, reaction devices such as a reaction tube, a gene chip, a PCR reaction plate and the like are placed in the concave structure in an aligned mode in advance, contents such as biochemical samples or substances are loaded in the reaction devices, heat generated by the semiconductor heating plate is transmitted to the reaction devices through the aluminum plate bracket, and therefore temperature regulation and control of the contents in the reaction devices can be achieved through temperature regulation and control of the semiconductor heating plate.
Firstly, because heat is transferred among the semiconductor heating sheet, the aluminum plate bracket and the reaction device in a heat conduction mode, and the heat conductivity coefficients of different media are different, a temperature change regulation process of temperature rise and temperature reduction of contents can be completed only by consuming a long time, so that the temperature change of the contents has certain hysteresis.
Secondly, the reaction device and the concave structure are arranged in a one-to-one alignment mode, and the reaction device is beneficial to heat conduction and ensures that the temperature of the contents is controllable only under the condition that the outer wall of the reaction device is completely attached to the inner wall of the concave structure; therefore, in a heating reaction period, the number of the heated reaction devices is limited, and the number of the reaction devices cannot be larger than that of the concave structures; meanwhile, the universality of the temperature control device is severely limited, and the reaction device and the concave structure are required to be kept highly matched in the aspects of shape, size, arrangement mode and the like.
The temperature control device provided by the application is mainly used for heating and temperature control of biochemical detection reaction, especially polymerase chain reaction or isothermal nucleic acid amplification detection reaction; heating air by a heating element, and conducting hot air into the temperature control main body by using a drainage fan, so as to heat a reaction piece to be heated in the temperature control main body in a hot air bath mode and adjust the temperature of the reaction piece to be heated; compared with the existing temperature control device, the temperature control device has the advantages that as long as the reaction piece to be heated is accommodated and placed in the temperature control main body, the temperature can be accurately and quickly controlled, the quick temperature change is realized, and the normal operation of the heating reaction is ensured; meanwhile, the number, size, shape, arrangement mode and the like of the reaction parts to be heated cannot be limited, and the universality of the device is greatly improved.
Referring to fig. 1 to 5 and 11, an embodiment provides a temperature control device, including a temperature control main body 10, a flow guiding fan 20 and a heating element 30, wherein the temperature control main body 10 mainly includes an air bath chamber 11, an air inlet portion 12, an air outlet portion 13 and an inlet/outlet 14; the following are described separately.
The air bath chamber 11 is mainly used for providing a placing space for the reaction piece A to be heated so as to accommodate the reaction piece A to be heated, so that the reaction piece A to be heated can complete heat exchange with air in the air bath chamber 11, and thus the temperature is raised or lowered; in this embodiment, the air bath chamber 11 is a hollow cubic structure, divided according to the direction, and has six side walls, namely, a front side wall, a rear side wall, a left side wall, a right side wall, an upper side wall and a lower side wall, and the side walls in different directions can be fully utilized to arrange the air inlet portion 12, the air outlet portion 13, the inlet and outlet 14 and the like. In other embodiments, the air bath chamber 11 may also adopt other structural forms according to practical situations, such as a hollow cylinder structure, a hollow polygonal structure, a spherical shell structure, and so on. By using the structural space provided by the air bath chamber 11, the reaction pieces A to be heated can be placed and contained as required without being limited by the number, size, shape, arrangement mode and the like.
It should be noted that: the reaction member a to be heated refers to a reaction device carrying contents, the reaction device includes but is not limited to a reaction tube, a gene chip, a PCR reaction plate, a detection tube and other conventional detection or experimental instruments, and the contents include but are not limited to polymerase, deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and other biochemical samples or substances.
The air inlet portion 12 is mainly used for allowing external air to flow into the air bath chamber 11 to provide a structural passage, the air inlet portion 12 is a tubular structure, the two air inlet portions 12 are symmetrically arranged on the left side and the right side of the air bath chamber 11, and the air bath chamber 11 can be communicated with the outside through the air inlet portion 12, so that the external air can enter the air bath chamber 11 from the left side and the right side of the air bath chamber 11 through the air inlet portion 12. In other embodiments, one or more air inlet portions 12 may be provided according to the structural configuration of the air bath chamber 11, the requirement of the air inlet amount, and other actual conditions, such as: air inlet portions 12 are respectively arranged on the left side, the right side and the rear side of the air bath chamber 11, and if the air inlet portions 12 are arranged on the left side or the right side of the air bath chamber 11.
The air outlet part 13 is mainly used for providing a structural channel for air to be discharged from the air bath cavity 11, and forms a finished air flow channel or air channel together with the air bath cavity 11 and the air inlet part 12, and the air outlet part 13 is arranged at the top of the air bath cavity 11 and can be a hollow opening arranged at the top of the air bath cavity 11 or a tubular structural body arranged at the top of the air bath cavity 11; in this embodiment, the air outlet portion 13 is located in the central area of the top of the air bath chamber 13, so that the air flow formed by the air can be intensively discharged from the air outlet portion 13 after entering the air bath chamber 11 from the left and right sides of the air bath chamber 11 through the air inlet portion 12, thereby ensuring that the temperatures of different areas in the air bath chamber 11 are kept consistent, and the air can fully and uniformly contact the reaction member a to be heated in the flowing process to complete heat exchange, thereby realizing the temperature rise or temperature reduction of the reaction member a to be heated.
The inlet and outlet 14 is mainly used as a taking and placing channel for the reaction piece a to be heated, so that the reaction piece a to be heated is placed and contained in the air bath chamber 11 to complete the heating reaction process, or the reaction piece a to be heated after the reaction is taken out from the air bath chamber 11; in this embodiment, the inlet and outlet 14 is provided on the front side wall of the air bath chamber 11 to meet the requirement of an operator to pick and place the reaction member a to be heated in a conventional manner; meanwhile, a movable door panel 15 can be arranged at the inlet and outlet 14, after the reaction member A to be heated is accommodated in the air bath chamber 11, the inlet and outlet 14 can be closed by using the movable door panel 15 or under the cooperation of the reaction member A to be heated, and a favorable structural space is created for the thermal reaction process of the reaction member A to be heated. In other embodiments, the access 14 may also be opened at the top of the air bath chamber 11 or on the side wall of the air bath chamber 11 in other directions, or when the air outlet portion 13 or the air inlet portion 12 is installed on the air bath chamber 11 in a hollow manner, the access 14 may be eliminated, and the air inlet portion 12 or the air outlet portion 13 may be directly used to replace the access 14; the key points are as follows: the reaction part A to be heated can be conveniently taken and placed by an operator.
The drainage fan 20 is mainly used for guiding airflow to sequentially flow through the air inlet part 12, the air bath chamber 11 and the air outlet part 13, so that the heat exchange with the reaction piece A to be heated is completed in a wind bath mode in the process that the air flows through the air bath chamber 11; in this embodiment, the flow guiding fan 10 is an axial flow fan and is installed at one end of the air inlet portion 12 far from the air bath chamber 11, so as to generate positive pressure in the temperature control main body 10, thereby pumping the external cold air into the air inlet portion 12, and finally discharging the air in the temperature control main body 10 through the air outlet portion 13, which can create conditions for selecting a low-power and miniaturized fan; in one embodiment, the draught fan 10 can also be installed in the air outlet portion 13, so as to generate negative pressure in the temperature control main body 10, thereby realizing suction and discharge of air, and being beneficial to reducing the arrangement number of the fans and simplifying the structural complexity of the whole device. In other embodiments, the induced draft fan 20 may also be a centrifugal fan based on the structural difference of the temperature control body 10 or the difference of the wind direction selection.
The heating element 30 is arranged in the air inlet part 12 and is mainly used for being electrically connected with the temperature control element B so as to heat air flow flowing through the air inlet part 12 under the control of the temperature control element B, so that the hot air enters the air bath chamber 11 and then exchanges heat with the reaction element A to be heated, and the temperature changing process of heating or cooling the reaction element A to be heated is realized; the heating member 30 may be an existing semiconductor heater or a thermal resistance heater, etc., as the case may be. In the present embodiment, the heating element 30 is a cone structure (also understood to be a tower structure), preferably a cone structure; wherein the central axis of the heating element 30 is coincident with the central line of the air inlet part 12, the conical bottom end of the heating element faces inwards (i.e. faces the air bath chamber 11), the conical top end faces outwards, thereby, the heating element 30 can be used to guide the air flow, so that the air can be heated and smoothly enter the air bath chamber 11 in the process of contacting with the heating element 30 in a large area, and the uniformity of the air temperature can be improved to the utmost extent under the matching of the structural layout of the air outlet part 13 and the air inlet part 12 (especially under the structural state that the air outlet part 12 is positioned at the top of the air bath chamber 11 and the air inlet part 12 is positioned at the left and the right sides of the air bath chamber 11), thereby making the temperature of different areas in the air bath chamber 11 relatively uniform, improving the utilization rate of heat and creating conditions for accelerating the temperature change rate of air (namely equivalent to the temperature change rate in the air bath chamber 11).
It should be noted that the temperature control element B may adopt a related function device capable of real-time controlling the heating power of the heating element 30 in the prior art, such as a controller capable of executing a computer program, and a switch element (e.g., a relay) for electrically connecting the heating element 30 with the controller and controlling the on/off of the circuit.
Based on this, the cold air is extracted from the outside of the device under the action of the drainage fan 20, so that the cold air is rapidly heated after entering the air inlet part 12 and contacting with the heating element 30, thereby forming hot air, and along with the flowing of air flow, the hot air can exchange heat with the reaction member A to be heated after entering the air bath chamber 11 so as to complete heating and temperature rise, and finally the air is discharged from the outside of the device through the air outlet part 13; on the contrary, when the temperature of the reaction member a to be heated needs to be reduced, the temperature control element B may be used to regulate the heating power of the heating element 30 or directly turn off the heating function of the heating element 30, so that air or cold air with relatively low temperature enters the air bath chamber 11 to flush away the air with relatively high temperature in the air bath chamber 11, and complete the heat exchange with the reaction member a to be heated.
The air is used as a carrier for heat transfer, and the heat exchange process with the reaction part A to be heated is completed in a wind bath mode, so that on one hand, the heat can be quickly transferred to the reaction part A to be heated, the temperature change process of quickly raising or lowering the temperature is realized, and the problem that the temperature change of the existing temperature control device lags can be effectively solved; on the other hand, the reaction member a to be heated can be placed in the temperature control main body 10 as required without being limited by factors such as size, number, shape, arrangement mode and the like, thereby effectively enhancing the universality of the whole device.
Referring to fig. 3 and fig. 11, an embodiment of the temperature control device further includes a temperature detecting element 40 electrically connected to the temperature control element B; specifically, the temperature detection part 40 is a temperature sensor, and at least the probe part of the temperature detection part 40 is arranged in the air bath chamber 11, so that the temperature information in the air bath chamber 11 is detected and acquired in real time through the temperature detection part 40, and the temperature information is output to the temperature control part B, so that the temperature control part B can compare the temperature information with a preset temperature threshold value, and the heating power of the heating part 30 is controlled or the heating part 30 is controlled to be turned on or off.
In one embodiment, the air bath chamber 11 further has a light-transmitting portion made of a light-transmitting material, so that light can enter the air bath chamber 11 through the light-transmitting portion, and after the reaction member a to be heated in the air bath chamber 11 completes a heating reaction of raising or lowering the temperature, an image (e.g., a static picture) of the reaction member a to be heated can be taken through the light-transmitting portion, so as to obtain a reaction result of the contents. In this embodiment, the light-transmitting portion is made of a quartz material with high light-transmitting performance, and may be a bottom independent structural member installed on the air bath chamber 11, or a bottom side wall or a portion of the bottom side wall of the air bath chamber 11.
In one embodiment, referring to fig. 2, 3 and 6, the heating element 30 is mainly composed of a conical skeleton 31 made of an insulating material and a heating wire 33 made of an alloy material, wherein the conical skeleton 31 is formed by cross-connecting two supporting plates having an overall shape of an isosceles trapezoid or an isosceles triangle, so that the radial cross-sectional shape of the conical skeleton 31 is approximately cross-shaped or "X" shaped, and the overall contour shape is approximately a cone or frustum; meanwhile, a plurality of clamping grooves 32 which are distributed side by side along the axial direction are arranged on the waist edge of the supporting plate (which can also be understood as the periphery of the conical framework 31); the heating wire 33 is wound and fixed on the conical framework 31 through the clamping groove 32, so that the whole heating element 30 forms a structure that the heating wire 33 is fully distributed on the periphery and is integrally in a conical structure or a tower structure, and by utilizing the structural gap between the conical framework 31 and the heating wire 33 and the structural gap between the heating wire 33 and the inner wall of the air inlet part 12, a channel can be provided for air flowing, so that the air can be in contact with the heating wire 33 in a large area, the air is heated to form hot air with relatively uniform temperature, and the flowing resistance of the air flow can be reduced. In practice, the temperature control element B is electrically connected to the heating wire 33, and the conical frame 31 can be connected to the air inlet portion 12 by providing an auxiliary structural member (such as a bracket, etc.), so as to fix the heating element 30 at a predetermined region position in the air inlet portion 12.
In other embodiments, the tapered skeleton 31 may be composed of at least three supporting plates with overall shapes of right trapezoid or right triangle, and the inner sides of the supporting plates are coaxially connected in a splicing manner, so that the radial section shape of the tapered skeleton 31 is approximately cross-shaped, X-shaped or radial. The conical framework 31 can also be composed of a shaft rod and a plurality of support rods, the shaft rod can be divided into a plurality of sections according to the winding turns of the heating wires 33, the support rods with the same length are arranged on each section along the circumferential direction, the length of the support rods on different sections is gradually increased from front to back along the length direction of the shaft rod, and therefore the conical framework 31 is formed, the carrier can be provided for winding of the heating wires 33 at the moment, and the wind resistance in the air inlet portion 12 can be reduced to the greatest extent.
Referring to fig. 2, 3, 7, 8, 9 and 10, an embodiment of the temperature control device further includes a guiding member 50, which is mainly used for uniformly mixing air (i.e., air flowing between the downstream of the heating member 30 and the upstream of the air inlet portion 12) so that the temperature of the air entering the air bath chamber 11 is uniform, thereby further enhancing the uniformity of the temperature of different areas in the air bath chamber 11, and at the same time, the air can uniformly enter the air bath chamber 11 to a certain extent; the baffle member 50 is disposed within the air inlet portion 12 between the heating member 30 and the air bath chamber 11, preferably as close as possible to the air bath chamber 11 or directly on the side wall of the air bath chamber 11.
In one embodiment, referring to fig. 2, 3 and 7, the flow guiding member 50 is a grid-type mesh plate structure, that is: mainly comprises a diversion main board 51 arranged in the air inlet part 12 and a plurality of diversion air ports 52 arranged on the diversion main board 51; wherein, the diversion main board 51 is a plate-shaped structure (such as a square plate or a round plate) with the peripheral outline shape matched with the cross section shape of the air inlet part 12, and part of the diversion tuyere 52 is provided with an inclined diversion surface 53, the inclined direction of the inclined diversion surface 53 can face the placing direction of the reaction piece A to be heated, the direction of the air outlet part 13, the direction of the front and back side walls of the air bath chamber 11, and the like; the key points are as follows: due to the existence of the heating element 30, the flowing direction of the air flow is changed after passing through the heating element 30, and the flowing direction and the area of the air flow can be adjusted by utilizing the structural form of the air guide opening 52 and the arrangement mode on the air guide main board 52, so that the air can uniformly enter the air bath chamber 11; meanwhile, because the temperature of the air adjacent to the heating element 30 is relatively high after being heated, and the temperature of the air far away from the heating element 30 is relatively low after being heated, the air with different temperatures can be uniformly mixed by utilizing the structural form of the air guide opening 52, so that the temperature of the air entering the air bath chamber 11 is consistent or uniform. Taking the air outlet part 13 arranged at the top of the air bath chamber 11, the air inlet part 12 arranged at the left and right sides of the air bath chamber 11, and the diversion member 50 and the air inlet part 12 both having a square structure as an example, the diversion tuyere 52 can adopt a through hole structure with a rectangular cross section shape, and the bottom surface of part of the diversion tuyere 52 is inclined upwards, and the side surface is inclined leftwards or rightwards, so that the air flow passing through the part of the diversion tuyere 52 can flow towards the upper left or upper right of the air bath chamber 11, thereby realizing the adjustment of the air flow direction or area.
In one embodiment, referring to fig. 8, the flow guiding element 50 may also be mainly composed of a main flow guiding pipe 54 installed in the air inlet portion 12 and a plurality of flow guiding vanes 55 disposed on the inner peripheral wall of the main flow guiding pipe 54; wherein, the diversion main pipe 54 is a plate-shaped structure (for example, the outer peripheral shape is square or round) whose outer peripheral contour shape matches the cross section shape of the air inlet part 12, so that the whole diversion member 50 can be fittingly assembled and fixed in the air inlet part 12, and at the same time, the diversion main pipe 54 is used to communicate the space of the air bath chamber 11 and the space of the air inlet part 12; the guide vanes 55 are uniformly distributed around the center line of the guide main pipe 54, and the guide vanes 55 adopt a curved sheet-shaped structure which is obliquely bent from the air inlet end (i.e., the end adjacent to the air inlet portion 12) to the air outlet end (i.e., the end adjacent to the air bath chamber 11) of the guide main pipe 54, so that by utilizing the structural form and the distribution mode of the guide vanes 55, a vortex effect can be generated in the process that air flows through the guide member 50, the air is fully disturbed and uniformly mixed, the effect of uniformly mixing the air can be achieved, and the temperature of the air entering the air bath chamber 11 is ensured to be uniform or even.
In other embodiments, the flow guiding element 50 may also be selectively arranged based on an existing fluid flow guiding device, as long as the air mixing function is performed or the air flow can be ensured to uniformly flow out from the outlet end of the flow guiding element 50, for example, the flow guiding element 50 may be structurally designed with reference to the structure shown in fig. 9 and 10, that is: the guiding element 50 is a tubular structure similar to a bell mouth, and has a guiding opening 52 formed by four inclined guiding surfaces 53, and the inclined angles of the four inclined guiding surfaces 53 are not completely the same, for example, the inclined guiding surface 53 located below is inclined and extends upwards greatly, so that the air is inclined towards the direction of the air outlet 13 as much as possible. All of these are not described in detail.
The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. Numerous simple deductions, modifications or substitutions may also be made by those skilled in the art in light of the present teachings.
Claims (10)
1. A temperature control device, comprising:
the temperature control main body is provided with an air bath cavity, an air inlet part and an air outlet part, the air bath cavity is communicated with the outside through the air inlet part and the air outlet part, and the air bath cavity is used for accommodating a reaction piece to be heated;
the drainage fan is used for guiding airflow to sequentially flow through the air inlet part, the air bath cavity and the air outlet part, and is arranged at the air inlet part and/or the air outlet part; and
the heating member for be connected with temperature control spare electricity, with the air current that the heating flowed through air inlet portion under the control of temperature control spare, the heating member sets up in air inlet portion.
2. The temperature control device of claim 1, further comprising a temperature detection member disposed within the air bath chamber, the temperature detection member being configured to acquire temperature information within the air bath chamber and being configured to electrically connect with the temperature control member to output the temperature information to the temperature control member.
3. The temperature control device according to claim 1, wherein the air bath chamber has a light-transmitting portion made of a light-transmitting material for transmitting light so as to obtain a reaction result by photographing an image of the reaction member to be heated.
4. The temperature control device according to claim 1, wherein the air bath chamber is provided with an inlet and an outlet for receiving the reaction member to be heated in the air bath chamber;
the air outlet part is positioned at the top of the air bath chamber, the air inlet part is a plurality of, and the air outlet and the air inlet parts are distributed along the circumferential direction of the air bath chamber.
5. The temperature control device according to claim 4, wherein the number of the air inlet portions is two, and the two air inlet portions are symmetrically distributed with respect to the air outlet portion.
6. The temperature control device of claim 1, further comprising a flow guide, the flow guide comprising:
the flow guide main board is positioned between the heating element and the air bath cavity and is a plate-shaped structural body of which the peripheral outline shape is matched with the cross section shape of the air inlet part; and
the air guide air inlet is used for uniformly mixing air flowing through the air guide main board, and one or more air guide air inlets are formed in the air guide main board.
7. The temperature control device of claim 1, further comprising a flow guide, the flow guide comprising:
the flow guide main pipe is positioned between the heating element and the air bath chamber and is a tubular structural body of which the peripheral outline shape is matched with the cross section shape of the air inlet part; and
guide vane for the mixing flows through the air that the water conservancy diversion was responsible for, guide vane is a plurality of and encircles the central line evenly distributed that the water conservancy diversion was responsible for on the internal perisporium that the water conservancy diversion was responsible for, guide vane is one from the inlet end that the water conservancy diversion was responsible for to giving vent to anger the end and do the curved surface slice structure of slope bending.
8. The temperature control device according to any one of claims 1 to 7, wherein the heating element is of a cone structure, a central axis of the heating element coincides with a central line of the air inlet portion, and a cone bottom end of the heating element faces the air bath chamber.
9. The temperature control device according to claim 8, wherein the heating member comprises:
the outer periphery of the conical framework is provided with a plurality of clamping grooves which are distributed side by side along the axial direction; and
the heating wire is used for being electrically connected with the temperature control part and is wound on the conical framework through the clamping groove.
10. The temperature control device of claim 9, wherein the tapered frame is a structure formed by a plurality of support plates that are cross-connected or coaxially joined, and the support plates are in the shape of at least one of an isosceles trapezoid, an isosceles triangle, a right trapezoid, and a right triangle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011429905.2A CN114606120A (en) | 2020-12-07 | 2020-12-07 | Temperature control device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011429905.2A CN114606120A (en) | 2020-12-07 | 2020-12-07 | Temperature control device |
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| CN114606120A true CN114606120A (en) | 2022-06-10 |
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| CN202011429905.2A Pending CN114606120A (en) | 2020-12-07 | 2020-12-07 | Temperature control device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117050851A (en) * | 2023-09-08 | 2023-11-14 | 中拓生物有限公司 | Heating device of nucleic acid extraction instrument |
| CN117804056A (en) * | 2024-02-29 | 2024-04-02 | 成都千麦医学检验所有限公司 | Temperature-changing incubator for enzyme-linked immunosorbent assay |
| CN117804056B (en) * | 2024-02-29 | 2024-05-14 | 成都千麦医学检验所有限公司 | Temperature-changing incubator for enzyme-linked immunosorbent assay |
-
2020
- 2020-12-07 CN CN202011429905.2A patent/CN114606120A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117050851A (en) * | 2023-09-08 | 2023-11-14 | 中拓生物有限公司 | Heating device of nucleic acid extraction instrument |
| CN117050851B (en) * | 2023-09-08 | 2024-04-12 | 中拓生物有限公司 | Heating device of nucleic acid extraction instrument |
| CN117804056A (en) * | 2024-02-29 | 2024-04-02 | 成都千麦医学检验所有限公司 | Temperature-changing incubator for enzyme-linked immunosorbent assay |
| CN117804056B (en) * | 2024-02-29 | 2024-05-14 | 成都千麦医学检验所有限公司 | Temperature-changing incubator for enzyme-linked immunosorbent assay |
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