CN114601799B - 用于关节润滑的脂质体制剂 - Google Patents

用于关节润滑的脂质体制剂 Download PDF

Info

Publication number
CN114601799B
CN114601799B CN202210282704.7A CN202210282704A CN114601799B CN 114601799 B CN114601799 B CN 114601799B CN 202210282704 A CN202210282704 A CN 202210282704A CN 114601799 B CN114601799 B CN 114601799B
Authority
CN
China
Prior art keywords
pharmaceutical composition
liposome
range
dmpc
joint
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202210282704.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN114601799A (zh
Inventor
Y·巴伦霍兹
Y·多乐夫
K·土尔曼
G·萨拉法蒂
M·埃尔-赫什科维茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mobis Medical Co ltd
Original Assignee
Mobis Medical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mobis Medical Co ltd filed Critical Mobis Medical Co ltd
Priority to CN202210282704.7A priority Critical patent/CN114601799B/zh
Publication of CN114601799A publication Critical patent/CN114601799A/zh
Application granted granted Critical
Publication of CN114601799B publication Critical patent/CN114601799B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202210282704.7A 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂 Active CN114601799B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210282704.7A CN114601799B (zh) 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762548429P 2017-08-22 2017-08-22
US62/548,429 2017-08-22
PCT/IL2018/050923 WO2019038763A1 (en) 2017-08-22 2018-08-21 LIPOSOMAL FORMULATION FOR JOINT LUBRICATION
CN202210282704.7A CN114601799B (zh) 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂
CN201880053772.8A CN111065423B (zh) 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880053772.8A Division CN111065423B (zh) 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂

Publications (2)

Publication Number Publication Date
CN114601799A CN114601799A (zh) 2022-06-10
CN114601799B true CN114601799B (zh) 2023-09-26

Family

ID=65439381

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202210282704.7A Active CN114601799B (zh) 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂
CN201880053772.8A Active CN111065423B (zh) 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880053772.8A Active CN111065423B (zh) 2017-08-22 2018-08-21 用于关节润滑的脂质体制剂

Country Status (25)

Country Link
US (3) US11123293B2 (https=)
EP (2) EP4223284A1 (https=)
JP (2) JP7082336B2 (https=)
KR (2) KR102607729B1 (https=)
CN (2) CN114601799B (https=)
AU (3) AU2018319594B2 (https=)
BR (1) BR112020003767B1 (https=)
CA (2) CA3073368C (https=)
DK (1) DK3672653T3 (https=)
EA (1) EA202090476A1 (https=)
ES (1) ES2948715T3 (https=)
FI (1) FI3672653T3 (https=)
HR (1) HRP20230566T1 (https=)
HU (1) HUE062030T2 (https=)
IL (3) IL272630B2 (https=)
LT (1) LT3672653T (https=)
MA (1) MA49959B1 (https=)
MX (2) MX2020002041A (https=)
MY (1) MY197149A (https=)
PH (1) PH12020500331A1 (https=)
PL (1) PL3672653T3 (https=)
PT (1) PT3672653T (https=)
SG (1) SG11202000773QA (https=)
SI (1) SI3672653T1 (https=)
WO (1) WO2019038763A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI782181B (zh) * 2019-02-11 2022-11-01 以色列商莫比斯醫療有限公司 用於關節潤滑的脂質體調配物
JP2021013788A (ja) * 2020-11-10 2021-02-12 株式会社三洋物産 遊技機
MX2024008401A (es) * 2022-01-02 2024-08-19 Moebius Medical Ltd Determinacion del volumen atrapado de un liposoma.
CA3266614A1 (en) 2023-01-19 2024-07-25 Moebius Medical Ltd. LONG-ACTING LIPOSOMAL COMPOSITION FOR THE TREATMENT OF PAIN IN JOINT DISORDERS
KR20250018222A (ko) * 2023-07-26 2025-02-05 차의과학대학교 산학협력단 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물
IL314549A (en) * 2024-07-25 2026-02-01 Moebius Medical Ltd Liposomal conjugates and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541308A (zh) * 2006-09-28 2009-09-23 哈达斯特医疗研究服务和开发有限公司 甘油磷脂用于关节润滑的用途

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403592A (en) 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
EP0319638A1 (en) * 1987-12-08 1989-06-14 Estee Lauder Inc. Liposome containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions
US5941909A (en) * 1995-02-14 1999-08-24 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
AUPN723395A0 (en) 1995-12-19 1996-01-18 Macnaught Medical Pty Limited Lubrication methods
US6379648B1 (en) * 1999-02-01 2002-04-30 The Curators Of The University Of Missouri Biodegradable glass compositions and methods for radiation therapy
US6800298B1 (en) * 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
CA2435418A1 (en) * 2001-01-24 2002-08-01 Mestex Ag Use of neurotoxic substances in producing a medicament for treating joint pains
US6509027B2 (en) 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
WO2002078445A1 (en) * 2001-03-29 2002-10-10 The Scripps Research Institute Formulations comprising entrapped active ingredients and uses thereof
JP2005525992A (ja) * 2001-06-25 2005-09-02 イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム 生物学的物質を充填した小胞の調製法およびそれらの様々な使用
WO2003000191A2 (en) 2001-06-25 2003-01-03 Depuy Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints
US20050123593A1 (en) 2001-06-25 2005-06-09 Jonathan Thompson Liposomal encapsulation of glycosaminoglycans for the treatment of arthritic joints
DE10255106A1 (de) * 2002-11-24 2004-06-09 Novosom Ag Liposomale Glucocorticoide
US7205006B2 (en) 2003-09-25 2007-04-17 Prime Pharmaceutical Corporation Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
DE602005010424D1 (de) 2004-06-03 2008-11-27 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
JP2008502690A (ja) 2004-06-15 2008-01-31 アンドリュー シァン チェン， リン脂質組成物ならびにその調製方法および使用方法
US20070071840A1 (en) 2005-09-27 2007-03-29 Sridevi Dhanaraj Method for treatment of cartilage disorders with centella extract
ITPD20060202A1 (it) 2006-05-22 2007-11-23 Univ Degli Studi Trieste Miscele polimeriche di polisaccaridi anionici e cationici e loro impiego
JP5072275B2 (ja) * 2006-07-03 2012-11-14 テルモ株式会社 閉鎖小胞の分離方法、製剤の製造方法および評価方法
US20080027554A1 (en) * 2006-07-31 2008-01-31 Talmadge Karen D Kit and methods of treatment of an intervertebral disc
US8834920B2 (en) 2006-12-21 2014-09-16 Alza Corporation Liposome composition for targeting egfr receptor
FR2918276B1 (fr) 2007-07-02 2010-01-22 Anteis Sa "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires"
JP2011512409A (ja) 2008-02-20 2011-04-21 イーエルシー マネージメント エルエルシー 皮膚を美白するための局所組成物及び方法
BR112012032153A2 (pt) * 2010-06-17 2017-08-08 Yeda Res And Development Company Ltd método para a lubrificação de uma ou mais superfícies não biológicas, método para a lubrificação de uma ou mais superfícies de um tecido biológico em um indivíduo mamífero, uso de lipossomas na fase em gel e lipossoma misto
IL206739A (en) * 2010-06-30 2016-06-30 David Segal An injectable drug containing silitol as an active substance
WO2012143876A1 (en) 2011-04-19 2012-10-26 Anteis S.A. A sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
GB201206486D0 (en) 2012-04-12 2012-05-30 Sequessome Technology Holdings Ltd Vesicular formulations and uses thereof
SI2854769T1 (sl) * 2012-07-05 2023-09-29 Taiwan Liposome Company, Ltd. Postopki za zdravljenje artritisa
CN104688721A (zh) * 2014-10-11 2015-06-10 黄萍 一种含紫杉醇脂质体的抗类风湿性关节炎药物凝胶剂及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541308A (zh) * 2006-09-28 2009-09-23 哈达斯特医疗研究服务和开发有限公司 甘油磷脂用于关节润滑的用途

Also Published As

Publication number Publication date
KR102808544B1 (ko) 2025-05-19
CA3073368A1 (en) 2019-02-28
US20200170948A1 (en) 2020-06-04
MA49959A (fr) 2020-07-01
MX2020002041A (es) 2020-08-13
KR20230166148A (ko) 2023-12-06
EP3672653A4 (en) 2021-01-13
US12214077B2 (en) 2025-02-04
IL272630B2 (en) 2023-09-01
IL312816B1 (en) 2026-02-01
JP7082336B2 (ja) 2022-06-08
AU2018319594B2 (en) 2023-06-15
AU2018319594A1 (en) 2020-02-20
US11123293B2 (en) 2021-09-21
PL3672653T3 (pl) 2023-08-14
IL272630A (en) 2020-03-31
CA3219776A1 (en) 2019-02-28
FI3672653T3 (fi) 2023-06-07
AU2025200077B2 (en) 2026-01-08
US20250114304A1 (en) 2025-04-10
AU2023203309A1 (en) 2023-06-22
SI3672653T1 (sl) 2023-08-31
WO2019038763A1 (en) 2019-02-28
US20210369613A1 (en) 2021-12-02
EP4223284A1 (en) 2023-08-09
EP3672653A1 (en) 2020-07-01
MY197149A (en) 2023-05-26
IL301801A (en) 2023-05-01
CN114601799A (zh) 2022-06-10
BR112020003767B1 (pt) 2023-10-10
EA202090476A1 (ru) 2020-06-29
DK3672653T3 (da) 2023-06-12
CN111065423B (zh) 2022-04-12
PH12020500331A1 (en) 2020-10-05
EP3672653B1 (en) 2023-03-29
AU2025200077A1 (en) 2025-01-23
CN111065423A (zh) 2020-04-24
IL312816A (en) 2024-07-01
AU2023203309B2 (en) 2024-10-10
ES2948715T3 (es) 2023-09-18
IL301801B1 (en) 2024-06-01
MA49959B1 (fr) 2023-07-31
MX2023009082A (es) 2023-08-08
HUE062030T2 (hu) 2023-09-28
KR102607729B1 (ko) 2023-11-29
JP2020531538A (ja) 2020-11-05
LT3672653T (lt) 2023-07-10
PT3672653T (pt) 2023-06-29
SG11202000773QA (en) 2020-03-30
CA3073368C (en) 2024-01-02
HRP20230566T1 (hr) 2023-08-18
JP7383759B2 (ja) 2023-11-20
IL272630B1 (en) 2023-05-01
NZ761298A (en) 2024-03-22
JP2022110090A (ja) 2022-07-28
KR20200044006A (ko) 2020-04-28
BR112020003767A2 (pt) 2020-09-01
IL301801B2 (en) 2024-10-01

Similar Documents

Publication Publication Date Title
CN114601799B (zh) 用于关节润滑的脂质体制剂
CN101541308B (zh) 甘油磷脂用于关节润滑的用途
TWI782181B (zh) 用於關節潤滑的脂質體調配物
HK40030411B (en) Liposomal formulation for joint lubrication
HK40030411A (en) Liposomal formulation for joint lubrication
EA052072B1 (ru) Липосомальный состав для обеспечения смазывающей среды сустава
EA042384B1 (ru) Липосомальный состав для обеспечения смазывающей среды сустава
BR122022020806B1 (pt) Composição farmacêutica que compreende lipossomas, processo para a preparação da mesma e usos da dita composição para lubrificar uma articulação e tratar dor ou irritação em uma articulação

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant