CN114594222A - Decoction piece detection method based on traditional Chinese medicine formula granules - Google Patents
Decoction piece detection method based on traditional Chinese medicine formula granules Download PDFInfo
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Abstract
The invention relates to a decoction piece detection method based on traditional Chinese medicine formula granules, which comprises the following steps: s1: obtaining preparation parameters of the traditional Chinese medicine formula particles; s2: calculating to obtain the lower limit of the water-alcohol soluble extract of the decoction pieces according to the preparation parameters; s3: measuring water-alcohol soluble extract of the actual decoction pieces; s4: judging whether the decoction pieces can be prepared into qualified traditional Chinese medicine formula granules according to whether the water-alcohol soluble extract of the actual decoction pieces is not lower than the lower limit of the water-alcohol soluble extract of the decoction pieces. The invention can effectively avoid using unqualified decoction pieces for production in advance, and can save a large amount of resources.
Description
Technical Field
The invention relates to the field of preparation of traditional Chinese medicine formula granules, in particular to a decoction piece detection method based on traditional Chinese medicine formula granules.
Background
Conceptually, the single Chinese medicine formula granule is a pure Chinese medicine product series which is prepared by taking traditional Chinese medicine decoction pieces which meet processing specifications as raw materials, and carrying out water extraction, concentration, separation, drying, granulation, packaging and refining by modern pharmaceutical technology. The active ingredients, the properties and the tastes, the channel tropism, the main treatment and the efficacy of the traditional Chinese medicine formula granules are completely consistent with those of the traditional Chinese medicine decoction pieces, the characteristics of the traditional Chinese medicine decoction pieces are kept, the characteristics of traditional monarch, minister, assistant and guide of the traditional Chinese medicine and the characteristics of dialectical treatment and flexible addition and subtraction can be ensured, the traditional Chinese medicine formula granules are superior to Chinese patent medicines, the trouble of traditional decoction of patients is avoided, and simultaneously, the traditional Chinese medicine formula granules can be flexibly taken with single granules, are sanitary and effective.
In the national standard of traditional Chinese medicine formula granules, the key detection indexes comprise 4 items such as cream yield, alcohol-soluble extract, main component content and characteristic spectrum.
In quality control of traditional Chinese medicine formula granules, finished products are mainly detected, but qualified traditional Chinese medicine formula granules cannot be obtained if decoction pieces adopted in preparation of the traditional Chinese medicine formula granules are unqualified, so that the waste of the decoction pieces is caused, and at present, no method or product is available for detecting the decoction pieces adopted in preparation of the traditional Chinese medicine formula granules to finish quality control of the traditional Chinese medicine formula granules.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a decoction piece detection method based on traditional Chinese medicine formula granules, which can effectively avoid using unqualified decoction pieces for production in advance and save a large amount of resources.
The purpose of the invention is realized by the following technical scheme:
a decoction piece detection method based on traditional Chinese medicine formula granules comprises the following steps:
s1: obtaining preparation parameters of the traditional Chinese medicine formula particles;
s2: calculating to obtain the lower limit of the water-alcohol soluble extract of the decoction pieces according to the preparation parameters;
s3: measuring the water-alcohol soluble extract of the actual decoction pieces;
s4: judging whether the decoction pieces can be prepared into qualified traditional Chinese medicine formula granules according to whether the water-alcohol soluble extract of the actual decoction pieces is not lower than the lower limit of the water-alcohol soluble extract of the decoction pieces.
Further, the preparation parameters comprise granule preparation amount, granule water upper limit, granule alcohol-soluble extract lower limit, maximum auxiliary material addition amount, auxiliary material alcohol-soluble extract, decoction piece feeding amount, decoction piece water and transfer rate.
Further, the preparation parameters are determined according to the detection result of the qualified particles and the determined preparation standard; the lower limit of the alcohol-soluble extract of the particles is determined according to the detection result of the alcohol-soluble extract of the qualified particles.
Further, the method for measuring the alcohol-soluble extract of the qualified granules comprises the following steps: taking a proper amount of qualified granules, grinding the qualified granules, precisely weighing, precisely adding ethanol into the qualified granules, and measuring by hot dipping method under alcohol-soluble extract measuring method (2201 in the four-part general rule of 2020 edition in Chinese pharmacopoeia).
As another design, the preparation parameters are determined according to the detection result of qualified particles and the determined preparation standard; the lower limit of the alcohol-soluble extract of the granules is determined according to the national standard of the traditional Chinese medicine formula granules.
Further, the lower limit of the water-alcohol soluble extract of the decoction pieces is calculated by the following formula:
decoction piece water-alcohol soluble extract lower limit ═ (granule prepared amount × (1-granule water upper limit) × granule alcohol soluble extract lower limit-maximum adjuvant added amount × adjuvant alcohol soluble extract) ÷ (decoction piece inventory amount × (1-decoction piece water))/(transfer rate × 100%
Further, the step S3 includes the following sub-steps:
s301: preparing the decoction pieces into dry paste powder;
s302: carrying out alcohol-soluble extract measurement on the dry paste powder to obtain dry paste powder alcohol-soluble extract;
s303: calculating according to the dry extract powder alcohol-soluble extract to obtain actual decoction piece water-alcohol-soluble extract.
Further, the calculation formula of the water-alcohol soluble extract of the actual decoction pieces is as follows:
water-alcohol soluble extract of actual decoction pieces, dry extract powder alcohol soluble extract x dry extract powder weight ÷ (decoction piece input amount x (1-decoction piece water content) when prepared into dry extract powder).
The invention has the beneficial effects that:
the production of unqualified decoction pieces can be effectively avoided in advance, and a large amount of resources can be saved.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.
The first embodiment is as follows:
a decoction piece detection method based on traditional Chinese medicine formula granules comprises the following steps:
s1: obtaining preparation parameters of the traditional Chinese medicine formula particles;
the preparation parameters comprise granule preparation amount, granule water upper limit, granule alcohol-soluble extract lower limit, maximum adjuvant addition amount, adjuvant alcohol-soluble extract, decoction piece feeding amount, decoction piece water and transfer rate;
the preparation parameters are determined based on the results of the testing of the acceptable particles and established preparation criteria (e.g., particle extract criteria).
The lower limit of the alcohol-soluble extract of the particles is determined according to the detection result of the alcohol-soluble extract of the qualified particles.
The method for measuring the alcohol-soluble extract of the qualified granules comprises the following steps: taking a proper amount of qualified particles, grinding the qualified particles, precisely weighing about 2g, precisely adding 50-100 ml of ethanol into the qualified particles, and measuring according to a hot dipping method under the item of an alcohol-soluble extract measuring method (2201 of the four-part general rule of 2020 edition in Chinese pharmacopoeia).
The lower limit of the alcohol-soluble extract of the granule can also be determined according to the national standard of the traditional Chinese medicine formula granule.
S2: calculating to obtain the lower limit of the water-alcohol soluble extract of the decoction pieces according to the preparation parameters;
the lower limit of the water-alcohol soluble extract of the decoction pieces is calculated by the following formula:
decoction piece water-alcohol soluble extract lower limit ═ (granule prepared amount × (1-granule water upper limit) × granule alcohol soluble extract lower limit-maximum adjuvant added amount × adjuvant alcohol soluble extract) ÷ (decoction piece inventory amount × (1-decoction piece water))/(transfer rate × 100%
This is because
Transfer rate ═ granule alcohol-soluble extract × theoretical prepared granule amount × (1-granule moisture) ÷ (decoction piece amount × (1-decoction piece moisture) × decoction piece water-alcohol-soluble extract)
S3: measuring water-alcohol soluble extract of the actual decoction pieces;
s301: preparing the decoction pieces into dry paste powder;
taking a proper amount of decoction pieces, preparing the decoction pieces into powder (sieving with a No. two sieve), adding 25 times of water, soaking for 1 hour, heating and refluxing for extraction for 1 hour, filtering the extract, concentrating under reduced pressure to be thick, and drying to obtain dry extract powder.
S302: carrying out alcohol-soluble extract measurement on the dry paste powder to obtain dry paste powder alcohol-soluble extract;
taking about 2g of the dry extract powder prepared in S301, precisely weighing, precisely adding 100ml of ethanol, and measuring by hot dipping method under alcohol soluble extract measuring method (2201 in the four-part general rule of China pharmacopoeia 2020 edition);
s303: calculating according to the alcohol-soluble extract of the dry extract powder to obtain water-alcohol-soluble extract of the actual decoction pieces;
the calculation formula of the water-alcohol soluble extract of the actual decoction pieces is as follows:
actual decoction piece water-alcohol soluble extract (dry extract powder alcohol soluble extract) x dry extract powder weight ÷ (decoction piece input amount x (1-decoction piece water) when prepared into dry extract powder)
S4: judging whether the decoction pieces can be prepared into qualified traditional Chinese medicine formula granules according to whether the water-alcohol soluble extract of the actual decoction pieces is not lower than the lower limit of the water-alcohol soluble extract of the decoction pieces.
If the water-alcohol soluble extract of the actual decoction pieces is not lower than the lower limit of the water-alcohol soluble extract of the decoction pieces, the decoction pieces can be prepared into qualified traditional Chinese medicine formula granules; if the water-alcohol soluble extract of the actual decoction pieces is lower than the lower limit of the water-alcohol soluble extract of the decoction pieces, the decoction pieces cannot be prepared into qualified traditional Chinese medicine formula granules.
Therefore, the production of unqualified decoction pieces can be effectively avoided, and a large amount of resources can be saved.
By referring to key indexes of traditional Chinese medicine formula granules, the concept of 'water-alcohol soluble extract' of decoction pieces is provided according to the following steps: the formula granule needs to measure alcohol-soluble extract, and is prepared by water extraction, concentration and drying. Therefore, the water-soluble extract of the decoction pieces is measured to obtain dry paste powder, and then the alcohol-soluble extract of the dry paste powder is measured, so that the water-alcohol-soluble extract result of the decoction pieces can be calculated. The corresponding relationship of the key indexes of the granules and the decoction pieces is as follows:
therefore, qualified granules can be prepared more easily by controlling the quality of decoction pieces.
Example two:
preparation of the charred hawthorn fruit (hawthorn fruit) traditional Chinese medicine formula particle and detection of the charred hawthorn fruit (hawthorn fruit) decoction pieces are carried out by adopting the decoction piece detection method based on the traditional Chinese medicine formula particle in the first embodiment.
The relevant detection data of the charred hawthorn fruit (hawthorn fruit) decoction pieces and the charred hawthorn fruit (hawthorn fruit) traditional Chinese medicine formula granules are shown in tables 1 and 2.
TABLE 1 detection data of charred fructus crataegi (fructus crataegi) decoction pieces
TABLE 2 detection data of charred fructus crataegi (fructus crataegi) Chinese medicinal granule
The traditional Chinese medicine formula granule prepared from charred hawthorn (hawthorn fruit) is specified in the national standard: 1. the preparation method comprises the following steps: decocting 2000g of scorched hawthorn decoction pieces with water, filtering, concentrating the filtrate into clear paste (the paste yield of the dry extract is 25-40%), adding a proper amount of auxiliary materials, drying (or drying and crushing), adding a proper amount of auxiliary materials, uniformly mixing, granulating and preparing into 1000 g. 2. It is determined by hot dipping method (China pharmacopoeia 2020 edition general rule 2201) under alcohol soluble extract determination method, using ethanol as solvent, and should not be less than 26.0%.
The water content of hawthorn in the lower jiao of item "hawthorn" in the first part of China pharmacopoeia 2020 is specified as follows: but not more than 12.0% (general 0832 second method).
The upper limit of the water content of the granules is 8.0 percent, and the auxiliary material alcohol-soluble extract is 2 percent.
The following preparation parameters were obtained:
the prepared amount of the granules is 1000g, the upper limit of the water content of the granules is 8.0 percent, the lower limit of the alcohol-soluble extract of the granules is 26.0 percent, the maximum addition amount of the auxiliary materials is 1000-
Determining the actual decoction piece water-alcohol soluble extract of the pieces of the crataegus pinnatifida (Shanlihong) by determining the lower limit of the water-alcohol soluble extract of the pieces (granule prepared amount x (1-granule water upper limit) x the lower limit of the alcohol soluble extract of the granules-maximum addition amount of the auxiliary material x the alcohol soluble extract of the granules) -adding rate of the auxiliary material x (feeding amount x (1-piece water))/(transfer rate x 100%)) (1000 x (1-8.0%) × 26.0% - (1000-; judging whether the charred hawthorn (hawthorn) decoction pieces can be prepared into qualified traditional Chinese medicine formula granules according to whether the water-alcohol soluble extract of the actual decoction pieces is not lower than the lower limit of the water-alcohol soluble extract of the decoction pieces.
The internal control standard of the actual water-alcohol soluble extract of the charred hawthorn (hawthorn) decoction pieces is formulated as follows: taking a proper amount of the product (screened by a No. two sieve), adding 25 times of water, soaking for 1 hour, heating and refluxing for extraction for 1 hour, filtering an extracting solution, concentrating under reduced pressure to be thick, drying, taking about 2g of dry extract powder, precisely weighing, precisely adding 100ml of ethanol, and measuring by a hot dipping method under the item of an alcohol-soluble extract measuring method (2201 of the four-part general rule of China pharmacopoeia 2020 edition), wherein the dry product is not less than 14.0 percent.
Namely, the decoction pieces with the water-alcohol soluble extract of the actual decoction pieces of more than 14.0 percent are selected to prepare the traditional Chinese medicine formula particle, so that the alcohol soluble extract of the traditional Chinese medicine formula particle can meet the national standard.
Example three:
the decoction piece detection method based on the traditional Chinese medicine formula granules is adopted to detect the decoction pieces of the white atractylodes rhizome aiming at the preparation of the traditional Chinese medicine formula granules.
The relevant data of the rhizoma atractylodis macrocephalae decoction pieces and the rhizoma atractylodis macrocephalae traditional Chinese medicine formula granules are shown in tables 3 and 4.
TABLE 3 rhizoma Atractylodis Macrocephalae decoction pieces test data
TABLE 4 Final product detection data for Baizhu TCM prescription granule
The white atractylodes rhizome formula particle is specified in the national standard: 1. the preparation method comprises the following steps: 1300g of largehead atractylodes rhizome decoction pieces are taken, water is added for decoction, filtration is carried out, filtrate is concentrated into clear paste (the paste yield of dry extract is 40% -74%), an appropriate amount of auxiliary materials are added, drying (or drying and crushing) are carried out, an appropriate amount of auxiliary materials are added, mixing uniformly and granulating are carried out, and 1000g of the mixture is prepared. 2. It is determined by hot dipping method (China pharmacopoeia 2020 edition general rule 2201) under alcohol soluble extract determination method, using ethanol as solvent, and should not be less than 5.0%. The water content of rhizoma Atractylodis Macrocephalae in the first part of the ' rhizoma Atractylodis ' of the ' 2020 edition of Chinese pharmacopoeia is specified as follows: but not more than 15.0% (general 0832 fourth method).
The upper limit of the water content of the granules is 8.0 percent, and the auxiliary material alcohol-soluble extract is 2 percent.
The following preparation parameters were obtained:
1000g of prepared granule, 8.0% of upper limit of water content of granule, 5.0% of lower limit of alcohol-soluble extract of granule, 1300 × 40% of maximum addition amount of adjuvant (prepared granule-minimum amount of clear paste obtained by concentrating decoction pieces of Atractylodis rhizoma), 2% of alcohol-soluble extract of adjuvant, 1300g of dosage of decoction pieces, 15.0% of water content of decoction pieces, and 76.94% of transfer rate (average value of transfer rate of extract in Table 4)
Decoction piece water-alcohol soluble extract lower limit ═ granule produced amount × (1-granule water upper limit) × granule alcohol soluble extract lower limit-maximum adjuvant added amount × adjuvant alcohol soluble extract ÷ decoction piece inventory amount × (1-decoction piece water))/transfer rate × 100 ═ 1000 × (1-8.0%) × 5.0% - (1000-
Measuring water-alcohol soluble extract of actual decoction pieces of Atractylodis rhizoma; judging whether the rhizoma atractylodis macrocephalae decoction pieces can be prepared into qualified traditional Chinese medicine formula granules according to whether the water-alcohol soluble extract of the actual decoction pieces is not lower than the lower limit of the water-alcohol soluble extract of the decoction pieces.
The internal control standard of the water-alcohol soluble extract of the decoction pieces of the largehead atractylodes rhizome is formulated as follows: taking a proper amount of the product (screened by a No. two sieve), adding 25 times of water, soaking for 1 hour, heating and refluxing for extraction for 1 hour, filtering an extracting solution, concentrating under reduced pressure to be thick, drying, taking about 2g of dry extract powder, precisely weighing, precisely adding 100ml of ethanol, and measuring by a hot dipping method under the item of an alcohol-soluble extract measuring method (2201 of the four-part general rule of China pharmacopoeia 2020 edition), wherein the content of the dried product is not less than 4.5 percent.
Namely, the decoction pieces with the water-alcohol soluble extract of the decoction pieces of more than 4.5 percent are selected to prepare the traditional Chinese medicine formula particle, so that the alcohol soluble extract of the traditional Chinese medicine formula particle meets the national standard.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (8)
1. A decoction piece detection method based on traditional Chinese medicine formula granules is characterized by comprising the following steps: the method comprises the following steps:
s1: obtaining preparation parameters of the traditional Chinese medicine formula particles;
s2: calculating to obtain the lower limit of the water-alcohol soluble extract of the decoction pieces according to the preparation parameters;
s3: measuring water-alcohol soluble extract of the actual decoction pieces;
s4: judging whether the decoction pieces can be prepared into qualified traditional Chinese medicine formula granules according to whether the water-alcohol soluble extract of the actual decoction pieces is not lower than the lower limit of the water-alcohol soluble extract of the decoction pieces.
2. The method for detecting decoction pieces based on traditional Chinese medicine formula granules according to claim 1, wherein the method comprises the following steps: the preparation parameters comprise granule preparation amount, granule water upper limit, granule alcohol soluble extract lower limit, maximum adjuvant adding amount, adjuvant alcohol soluble extract, decoction piece feeding amount, decoction piece water and transfer rate.
3. The method for detecting decoction pieces based on traditional Chinese medicine formula granules according to claim 2, wherein the method comprises the following steps: the preparation parameters are determined according to the detection result of the qualified particles and the determined preparation standard; the lower limit of the alcohol-soluble extract of the particles is determined according to the detection result of the alcohol-soluble extract of the qualified particles.
4. The method for detecting decoction pieces based on traditional Chinese medicine formula granules according to claim 3, wherein the method comprises the following steps: the method for measuring the alcohol-soluble extract of the qualified granules comprises the following steps: taking a proper amount of qualified granules, grinding the qualified granules, precisely weighing, precisely adding ethanol into the qualified granules, and measuring by hot dipping method under alcohol-soluble extract measuring method (2201 in the four-part general rule of 2020 edition in Chinese pharmacopoeia).
5. The method for detecting decoction pieces based on traditional Chinese medicine formula granules according to claim 2, wherein the method comprises the following steps: the preparation parameters are determined according to the detection result of the qualified particles and the determined preparation standard; the lower limit of the alcohol-soluble extract of the granules is determined according to the national standard of the traditional Chinese medicine formula granules.
6. The method for detecting decoction pieces based on TCM granules according to any one of claims 2-5, wherein the method comprises the following steps: the calculation formula of the lower limit of the water-alcohol soluble extract of the decoction pieces is as follows:
the lower limit of water-alcohol soluble extract of decoction pieces is (granule prepared amount x (1-granule water upper limit) x granule alcohol soluble extract lower limit-maximum adjuvant adding amount x adjuvant alcohol soluble extract)/(dosage of decoction pieces x (1-decoction piece water))/(transfer rate x 100%).
7. The method for detecting herbal pieces based on TCM prescription granule as claimed in claim 1, wherein: the step S3 includes the following sub-steps:
s301: preparing the decoction pieces into dry paste powder;
s302: carrying out alcohol-soluble extract measurement on the dry paste powder to obtain dry paste powder alcohol-soluble extract;
s303: calculating according to the dry extract powder alcohol-soluble extract to obtain actual decoction piece water-alcohol-soluble extract.
8. The method for detecting decoction pieces based on TCM prescription granule as claimed in claim 7, wherein: the calculation formula of the water-alcohol soluble extract of the actual decoction pieces is as follows:
water-alcohol soluble extract of actual decoction pieces, dry extract powder alcohol soluble extract x dry extract powder weight ÷ (decoction piece input amount x (1-decoction piece water content) when prepared into dry extract powder).
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Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474290A (en) * | 2007-12-18 | 2009-07-08 | 北京康仁堂药业有限公司 | Figwort root dispensing granule as well as preparation method and quality control method thereof |
| CN103070920A (en) * | 2013-02-03 | 2013-05-01 | 葛强 | Preparation process of novel salvia miltiorrhiza submicron powder particle traditional Chinese medicine decoction pieces |
| WO2014201994A1 (en) * | 2013-06-17 | 2014-12-24 | 天士力制药集团股份有限公司 | Salvia miltiorrhiza extract, micropellet formulation thereof, methods of preparing same, and uses thereof |
| CN104280360A (en) * | 2014-09-26 | 2015-01-14 | 广东一方制药有限公司 | Preparation and quality control method of liquorice formula granules |
| CN105404773A (en) * | 2015-08-24 | 2016-03-16 | 北京康仁堂药业有限公司 | Clinical curative effect evaluation method and evaluation apparatus for traditional Chinese medicine formula granule prescription |
| CN106138126A (en) * | 2016-08-08 | 2016-11-23 | 湖南盟合投资管理有限公司 | The preparation method of Balanophora dioica R Br ex Royle breaking cellular wall decoction pieces |
| CN109568417A (en) * | 2018-07-26 | 2019-04-05 | 广东方制药有限公司 | A kind of cape jasmine processes the preparation method of medicine materical crude slice granule |
| CN109939142A (en) * | 2019-04-03 | 2019-06-28 | 安徽济人药业有限公司 | A kind of preparation method and its method of quality control of cudrania root granule |
| CN109985076A (en) * | 2019-04-03 | 2019-07-09 | 安徽济人药业有限公司 | A kind of preparation method and its method of quality control of Pterospermi Heterophylli granule |
| CN110496152A (en) * | 2019-09-27 | 2019-11-26 | 上海蔡同德堂中药制药厂有限公司 | A kind of preparation process of Danshen Tablets |
| CN110870903A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Yam formula particle and preparation method and application thereof |
| CN110870883A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Bighead atractylodes rhizome formula particle and preparation method and application thereof |
| CN114224918A (en) * | 2021-12-20 | 2022-03-25 | 广东一方制药有限公司 | Donkey-hide gelatin bead decoction pieces, donkey-hide gelatin bead extract, donkey-hide gelatin bead traditional Chinese medicine formula granules and preparation method thereof |
-
2022
- 2022-03-29 CN CN202210318482.XA patent/CN114594222B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474290A (en) * | 2007-12-18 | 2009-07-08 | 北京康仁堂药业有限公司 | Figwort root dispensing granule as well as preparation method and quality control method thereof |
| CN103070920A (en) * | 2013-02-03 | 2013-05-01 | 葛强 | Preparation process of novel salvia miltiorrhiza submicron powder particle traditional Chinese medicine decoction pieces |
| WO2014201994A1 (en) * | 2013-06-17 | 2014-12-24 | 天士力制药集团股份有限公司 | Salvia miltiorrhiza extract, micropellet formulation thereof, methods of preparing same, and uses thereof |
| CN104280360A (en) * | 2014-09-26 | 2015-01-14 | 广东一方制药有限公司 | Preparation and quality control method of liquorice formula granules |
| CN105404773A (en) * | 2015-08-24 | 2016-03-16 | 北京康仁堂药业有限公司 | Clinical curative effect evaluation method and evaluation apparatus for traditional Chinese medicine formula granule prescription |
| CN106138126A (en) * | 2016-08-08 | 2016-11-23 | 湖南盟合投资管理有限公司 | The preparation method of Balanophora dioica R Br ex Royle breaking cellular wall decoction pieces |
| CN109568417A (en) * | 2018-07-26 | 2019-04-05 | 广东方制药有限公司 | A kind of cape jasmine processes the preparation method of medicine materical crude slice granule |
| CN110870903A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Yam formula particle and preparation method and application thereof |
| CN110870883A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Bighead atractylodes rhizome formula particle and preparation method and application thereof |
| CN109939142A (en) * | 2019-04-03 | 2019-06-28 | 安徽济人药业有限公司 | A kind of preparation method and its method of quality control of cudrania root granule |
| CN109985076A (en) * | 2019-04-03 | 2019-07-09 | 安徽济人药业有限公司 | A kind of preparation method and its method of quality control of Pterospermi Heterophylli granule |
| CN110496152A (en) * | 2019-09-27 | 2019-11-26 | 上海蔡同德堂中药制药厂有限公司 | A kind of preparation process of Danshen Tablets |
| CN114224918A (en) * | 2021-12-20 | 2022-03-25 | 广东一方制药有限公司 | Donkey-hide gelatin bead decoction pieces, donkey-hide gelatin bead extract, donkey-hide gelatin bead traditional Chinese medicine formula granules and preparation method thereof |
Non-Patent Citations (9)
| Title |
|---|
| 代云桃;靳如娜;吴治丽;刘安;张铁军;陈士林;: "基于标准汤剂(物质基准)的经典名方制备工艺和质量标准研究", 中国实验方剂学杂志, no. 02 * |
| 刘俊宏: "丹参配方颗粒的制备工艺及质量控制研究", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
| 康阿龙;汤迎爽;张苏蘅;: "市售荷叶药材及炮制品饮片质量评价的研究", 中国药事, no. 06 * |
| 杨静伟;杨晶凡;: "冬瓜子配方颗粒的提取工艺研究", 黑龙江医药, no. 04 * |
| 药监局: "中药配方颗粒质量控制与标准制定技术要求", Retrieved from the Internet <URL:www.gov.cn/zhengce/zhengceku/2021-02/11/content_5586817.htm> * |
| 邵家德: "中药常规煎法所得水溶性浸出物与配方颗粒之量比", 《中华中医药学会第四届中药炮制学术会议论文集》, pages 176 - 177 * |
| 韩吴琦;李清芳;黄永丽;: "对中药饮片质量标准研究的思考", 中国药房, no. 47 * |
| 饶君凤: "中药饮片与其对应配方颗粒浸出物含量比较分析", 《中国药房》, pages 1438 - 1439 * |
| 龙全江;徐茂保;: "当归饮片软化切制工艺研究", 中成药, no. 04 * |
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